Nigel E Drury, Carin van Doorn, Rebecca L Woolley, Rebecca J Amos-Hirst, Rehana Bi, Collette M Spencer, Kevin P Morris, James Montgomerie, John Stickley, Adrian Crucean, Alicia Gill, Matt Hill, Ralf J M Weber, Lukas Najdekr, Andris Jankevics, Andrew D Southam, Gavin R Lloyd, Osama Jaber, Imre Kassai, Giuseppe Pelella, Natasha E Khan, Phil Botha, David J Barron, Melanie Madhani, Warwick B Dunn, Natalie J Ives, Paulus Kirchhof, Timothy J Jones
OBJECTIVE: The study objective was to determine whether adequately delivered bilateral remote ischemic preconditioning is cardioprotective in young children undergoing surgery for 2 common congenital heart defects with or without cyanosis. METHODS: We performed a prospective, double-blind, randomized controlled trial at 2 centers in the United Kingdom. Children aged 3 to 36 months undergoing tetralogy of Fallot repair or ventricular septal defect closure were randomized 1:1 to receive bilateral preconditioning or sham intervention...
April 2024: JTCVS open