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https://www.readbyqxmd.com/read/29054041/cardiovascular-obstetric-and-neonatal-outcomes-in-women-with-previous-fontan-repair
#1
REVIEW
S J Bonner, O Asghar, A Roberts, S Vause, B Clarke, B Keavney
OBJECTIVES: To determine cardiovascular, obstetric and neonatal outcomes of pregnancies in women who have a Fontan circulation. METHODS: A retrospective case note review of all women with a Fontan circulation who attended the joint obstetric cardiac antenatal clinic at St Mary's Hospital, Manchester (UK) between 2004 and 2016 was performed. RESULTS: In total, there were 19 pregnancies in 9 women with a history of Fontan repair. 23 women with univentricular physiology attended in this time period...
October 16, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29053777/movement-disorders-with-neuronal-antibodies-syndromic-approach-genetic-parallels-and-pathophysiology
#2
Bettina Balint, Angela Vincent, Hans-Michael Meinck, Sarosh R Irani, Kailash P Bhatia
Movement disorders are a prominent and common feature in many autoantibody-associated neurological diseases, a group of potentially treatable conditions that can mimic infectious, metabolic or neurodegenerative disease. Certain movement disorders are likely to associate with certain autoantibodies; for example, the characteristic dyskinesias, chorea and dystonia associated with NMDAR antibodies, stiff person spectrum disorders with GAD, glycine receptor, amphiphysin or DPPX antibodies, specific paroxysmal dystonias with LGI1 antibodies, and cerebellar ataxia with various anti-neuronal antibodies...
September 25, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053529/use-of-service-learning-to-teach-health-literacy-with-online-graduate-nursing-students
#3
Tracy P George, Claire DeCristofaro
To meet Healthy People 2020 goals, health literacy must be included in health care program curricula. In a fully online graduate nursing course, an innovative service-learning activity asked students to collaborate in the creation of low-literacy patient education pamphlets for practice partners at a community rehabilitation facility. Involvement with community stakeholders such as support groups and interprofessional team members enhanced interdisciplinary educational outcomes. Through this innovative project-based activity, students were able to meet the clinical education and decision support needs of rehabilitation patients while translating academic coursework to support actual community needs...
October 20, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29053500/the-community-orthopaedic-surgeon-taking-trauma-call-pediatric-femoral-shaft-fracture-pearls-and-pitfalls
#4
J Eric Gordon, Charles T Mehlman
Pediatric femoral shaft fractures present many challenging patient care decisions. Nonoperative treatment approaches still dominate care of the youngest age groups while surgical intervention is commonplace in virtually all older children. Treatment is determined primarily by patient age as modified by clinical factors including mechanism of injury, weight, and skeletal maturity. Infants can be successfully treated by placement into a Pavlik harness, whereas children younger than 5 years are most commonly treated by early reduction and spica cast immobilization...
November 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29053390/exploring-the-teaching-and-learning-of-clinical-reasoning-risks-and-benefits-of-cervical-spine-manipulation
#5
Katie Yamamoto, Luca Condotta, Chloe Haldane, Sahar Jaffrani, Victoria Johnstone, Patrick Jachyra, Barbara E Gibson, Euson Yeung
The aim of this study was to examine how risks and benefits of cervical spine manipulation (CSM) were framed and discussed in the context of mentorship and their impact on the perception of safe practice of CSM in clinical physiotherapy settings. A multi-method qualitative approach was employed, including a document analysis of established educational guidelines, observations of mentoring sessions, and individual face-to-face interviews with five mentees in the process of learning CSM, and four mentors with Orthopedic Manual Physical Therapy (OMPT) certification...
October 20, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29053049/a-bayesian-meta-analysis-method-for-estimating-risk-difference-of-rare-events
#6
Yuanyuan Tang, Qi Tang, Yao Yu, Shihua Wen
Bayesian meta-analysis has been more frequently utilized for synthesizing safety and efficacy information to support landmark decision-making due to its flexibility of incorporating prior information and availability of computing software. However, when the outcome is binary and the events are rare, where event counts can be zero, conventional meta-analysis methods including Bayesian methods may not work well. Several methods have been proposed to tackle this issue but the prior knowledge of event rate was not utilized to increase precision of risk difference estimates...
October 20, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/29052818/out-of-pocket-cost-is-a-barrier-to-therapeutic-drug-monitoring-in-inflammatory-bowel-disease
#7
James P Campbell, Erin Burton, Shelly Wymer, Michael Shaw, Byron P Vaughn
BACKGROUND: Therapeutic drug monitoring (TDM) is increasingly performed to optimize biologic therapy in inflammatory bowel disease (IBD). However, patients and physicians may be reluctant to perform TDM due to concerns related to potential out-of-pocket costs. AIMS: The aim of this study was to evaluate patient understanding and attitudes toward TDM in different clinical scenarios with and without potential out-of-pocket costs. METHODS: Adult IBD patients at a tertiary gastroenterology clinic were anonymously surveyed from March to September 2016 to assess their understanding of and willingness to undergo TDM in a variety of clinical scenarios, both with and without a potential out-of-pocket cost...
October 20, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29052571/susceptibility-weighted-imaging-in-thrombolytic-therapy-of-acute-ischemic-stroke
#8
REVIEW
Lin Li, Ming-Su Liu, Guang-Qin Li, Yang Zheng, Tong-Li Guo, Xin Kang, Mao-Ting Yuan
OBJECTIVE: To provide a comprehensive and latest overview of susceptibility-weighted imaging (SWI) in the application of thrombolysis in acute ischemic stroke, and to update the decision-making effect and clinical value of SWI on identifying stroke patients suitable for thrombolytic therapy and possible benefits and risks followed. DATA SOURCES: Literatures referred to this review were collected from PubMed, Medline, and EMBASE published till May 2017, using the search terms including susceptibility-weighted imaging, gradient-echo, T2*, thrombolysis, recombinant tissue plasminogen activator (rt-PA), thrombolytic therapy, and stroke...
October 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29052503/intensive-follow-up-for-women-with-breast-cancer-review-of-clinical-economic-and-patient-s-preference-domains-through-evidence-to-decision-framework
#9
Alessandra Lafranconi, Liisa Pylkkänen, Silvia Deandrea, Anke Bramesfeld, Donata Lerda, Luciana Neamțiu, Zuleika Saz-Parkinson, Margarita Posso, David Rigau, Ivan Sola, Pablo Alonso-Coello, Maria José Martinez-Zapata
BACKGROUND: Women treated for breast cancer are followed-up for monitoring of treatment effectiveness and for detecting recurrences at an early stage. The type of follow-up received may affect women's reassurance and impact on their quality of life. Anxiety and depression among women with breast cancer has been described, but little is known about how the intensity of the follow-up can affect women's psychological status. This study was undertaken to evaluate the effects of intensive vs...
October 19, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29052262/diversion-evaluations-a-specialized-forensic-examination
#10
Virginia Barber-Rioja, Merrill Rotter, Faith Scombs
Diversion programs screen justice-involved individuals for the presence of psychiatric disorders, and after negotiations take place with attorneys and treatment providers, these programs link participants with community-based treatment programs in lieu of incarceration. As the number of diversion programs, including mental health courts, continues to rapidly grow, so does the need for "diversion evaluations". Diversion evaluations are a type of forensic mental health assessment (FMHA) conducted to assist the courts in making decisions regarding diversion eligibility...
October 19, 2017: Behavioral Sciences & the Law
https://www.readbyqxmd.com/read/29052162/international-regulations-and-recommendations-for-utility-data-for-health-technology-assessment
#11
REVIEW
Donna Rowen, Ismail Azzabi Zouraq, Helene Chevrou-Severac, Ben van Hout
Recommendations and guidelines for the collection, generation, source and usage of utility data for health technology assessment (HTA) vary across different countries, with no international consensus. Many international agencies generate their own guidelines providing details on their preferred methods for HTA submissions, and there is variability in both what they recommend and the clarity and amount of detail provided in their guidelines. This article provides an overview of international regulations and recommendations for utility data in HTA for a selection of key HTA countries: Australia, Canada, France, Germany, the Netherlands, Spain (Catalonia), Sweden and the UK (England/Wales and Scotland)...
October 19, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29052159/recommended-methods-for-the-collection-of-health-state-utility-value-evidence-in-clinical-studies
#12
REVIEW
Roberta Ara, John Brazier, Tracey Young
A conceptual model framework and an initial literature review are invaluable when considering what health state utility values (HSUVs) are required to populate health states in decision models. They are the recommended starting point early within a research and development programme, and before development of phase III trial protocols. While clinical trials can provide an opportunity to collect the required evidence, their appropriateness should be reviewed against the requirements of the model structure taking into account population characteristics, time horizon and frequency of clinical events...
October 19, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29052158/estimating-health-state-utility-values-for-comorbidities
#13
REVIEW
Roberta Ara, John Brazier
A comorbidity is defined as the presence of at least one additional health condition co-occurring with a primary health condition. Decision analytic models in healthcare depict the typical clinical pathway of patients in general clinical practice and frequently include health states defined to represent comorbidities such as sequelae or adverse events. Health state utility values (HSUVs) are often not available for these and analysts generally estimate them. This article provides a summary of the methodological literature on estimating methods frequently used together with worked examples...
October 19, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29051879/the-destructive-power-of-circumstance-on-concurrent-poliomyelitis-and-osteomyelitis
#14
Delran Anandkumar, Ananthakrishnan Raghupathi, Ragai Gadelrab
INTRODUCTION: The current method in dealing with pediatric hip pathologies is to avoid joint replacement unless absolutely necessary. This decision is typically made on a scientific basis. However, this is not necessarily the correct approach in all cases as demonstrated in the following case report where social issues is an extremely important variable to be considered when deciding on surgical intervention. CASE REPORT: This case report is the first of its kind to highlight the pathology mentioned and the social determinants that were a causative agent in its development...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29051869/case-of-acute-concomitant-rupture-of-anterior-cruciate-ligament-and-patellar-tendon-of-knee-surgical-decision-making-and-outcome
#15
Jithin Orville Lobo, Joe Joseph Cherian, Arnav Sahu
INTRODUCTION: Acute concomitant rupture of both anterior cruciate ligament (ACL) and patellar tendon is a rare injury. The diagnosis of either of the injuries may be missed on clinical examination in the emergency room. A high index of suspicion is necessary when active extension is absent, and necessary investigations like ultrasound or magnetic resonance imaging (MRI) should be done to confirm the diagnosis. There are no fixed treatment protocols in these injuries. The options include immediate repair of patellar tendon with either simultaneous or delayed reconstruction of ACL...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29051841/perceived-cost-advantages-and-disadvantages-of-purchasing-hiv-self-testing-kits-among-urban-tanzanian-men-an-inductive-content-analysis
#16
Larissa Jennings, Donaldson F Conserve, Jamison Merrill, Lusajo Kajula, Juliet Iwelunmor, Sebastian Linnemayr, Suzanne Maman
Impoverished men have lower rates of facility-based HIV counseling and testing and higher unknown HIV-positive status than women. Economic theory suggests that individuals will obtain an HIV test if anticipated benefits are greater than anticipated costs. Yet, few studies have investigated the range of financial preferences of HIV self-testing (HIVST) among poor men who decline testing or do not test regularly. Twenty-three interviews were conducted to qualitatively assess perceived costs saved and costs incurred from use of HIVST kits in infrequently- or never-tested Tanzanian men...
August 2017: Journal of AIDS & Clinical Research
https://www.readbyqxmd.com/read/29051528/induced-seismicity-closed-form-traffic-light-system-for-actuarial-decision-making-during-deep-fluid-injections
#17
A Mignan, M Broccardo, S Wiemer, D Giardini
The rise in the frequency of anthropogenic earthquakes due to deep fluid injections is posing serious economic, societal, and legal challenges to many geo-energy and waste-disposal projects. Existing tools to assess such problems are still inherently heuristic and mostly based on expert elicitation (so-called clinical judgment). We propose, as a complementary approach, an adaptive traffic light system (ATLS) that is function of a statistical model of induced seismicity. It offers an actuarial judgement of the risk, which is based on a mapping between earthquake magnitude and risk...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29050714/when-does-intraoperative-blood-loss-occur-during-pediatric-scoliosis-correction
#18
Sean Wahlquist, Montri Wongworawat, Scott Nelson
BACKGROUND: The purpose of our study was to assess the relationship between amount of blood loss and surgical stage in pediatric patients undergoing posterior spinal fusion for deformity correction to determine: (1) when the highest rate of blood loss occurred; (2) what percentage of total blood loss occurred during deformity correction and closure; and (3) how to predict remaining blood loss during a procedure. Blood loss following exposure and placement of the final pedicle screw is often underestimated, which may result in lack of sufficient blood product availability...
November 2017: Spine Deformity
https://www.readbyqxmd.com/read/29050700/the-what-when-and-how-of-car-t-cell-therapy-for-all
#19
REVIEW
Noelle Frey
Chimeric Antigen Receptor (CAR) T cells that have been engineered to target CD19 have shown great promise in patients with relapsed and refractory B cell acute lymphocytic leukemia with remission rates of 70-90%. Some remissions have successfully bridged patients to a curable allogeneic stem cell transplant, some responses have been durable without further treatment, and some patients have achieved durable remissions for relapsed ALL after allogeneic stem cell transplant. Cytokine release syndrome, correlating with the in vivo activation and expansion of T cells, and neurologic toxicity are the most significant side effects and approaches to better understand and manage these events are the subject of ongoing clinical trials...
September 2017: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29050697/how-do-we-measure-mrd-in-all-and-how-should-measurements-affect-decisions-re-treatment-and-prognosis
#20
REVIEW
Xueyan Chen, Brent L Wood
Minimal residual disease (MRD) is the most significant independent prognostic factor in acute lymphocytic leukemia (ALL). Monitoring MRD using sensitive techniques, including multiparametric flow cytometry (MFC) and quantitative polymerase chain reaction (qPCR)-based methods, has improved the assessment of treatment response and risk stratification for clinical management. New molecular methods, such as high-throughput next-generation sequencing (NGS), have evolved into routine laboratory tools to improve the sensitivity and specificity of MRD detection...
September 2017: Best Practice & Research. Clinical Haematology
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