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https://www.readbyqxmd.com/read/27875365/clear-cell-papulosis-report-of-a-case-with-unique-clinical-and-histologic-findings
#1
Josie Eiras Bisi Dos Santos, Mario Fernando Ribeiro de Miranda
Clear cell papulosis is a rare, self-limited, benign disease of early childhood, characterized by white macules and flat papules over the milk line. Histopathologically, it is characterized by scattered clear cells throughout the basal and/or suprabasal epidermal layers, which-as clear cells of Toker of the nipple do-typically express cytokeratin 7. They also exhibit other markers expected for adenoid differentiation, such as low-molecular weight cytokeratins, carcinoembryonic antigen, epithelial membrane antigen, and mucin...
December 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27871620/clinicopathologic-variants-of-mycosis-fungoides
#2
H Muñoz-González, A M Molina-Ruiz, L Requena
Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma. The clinical course of the disease is typically characterized by progression from a nonspecific phase of erythematous macules to the appearance of plaques and ultimately, in some patients, tumors. However, numerous clinical and histopathologic variants of MF with specific therapeutic and prognostic implications have been described in recent decades. Clarification of the differential diagnosis can be frustrated by the wide range of clinical manifestations and histopathologic patterns of cutaneous infiltration, particularly in the early phases of the disease...
November 18, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27853914/non-dermatophyte-dermatoses-mimicking-dermatophytoses-in-animals
#3
Didier Pin
Dermatophytoses in animals are fungal diseases of the skin caused by dermatophyte fungi of the genus Microsporum or Trichophyton. Because the infection is generally follicular, the most common clinical sign is one or many circular areas of alopecia with variable erythema, scaling and crusting, and the primary differential diagnoses are follicular infections, such as bacterial folliculitis and demodicosis. Although dermatophyte folliculitis or ringworm is the most commonly observed lesion of dermatophytoses in animals, other presentations may be observed according to the host species and the dermatophyte involved: dermatophyte folliculitis or ringworm, scaling and crusting in dermatophytosis due to Microsporum persicolor, nodule in case of kerion or mycetoma, matted hairs, seborrheic dermatosis or miliary dermatitis in cats, generalized exfoliative dermatoses in dogs, cats and horses, superficial non-follicular pustules, papules and macules in the Devon Rex cat, pruritic dermatophytoses in dogs, cats and horses, and onychomycosis in dogs, cats and horses...
November 16, 2016: Mycopathologia
https://www.readbyqxmd.com/read/27823913/-cutaneous-lesions-during-hot-tub-hypersensitivity-pneumonitis-pseudomonas-folliculitis%C3%A2
#4
N Sokolowsky, L Rolland, M-A Vandenhende, J-Y Colin, F Laurent, P Morlat, F Bonnet, M Beylot-Barry
BACKGROUND: Interstitial lung disease, cutaneous rash and elevated serum angiotensin converting enzyme (ACE) may suggest diagnoses other than sarcoidosis. PATIENTS AND METHODS: A 58-year-old man had presented dyspnoea for 2 years with increased angiotensin-converting enzyme, as well as an interstitial syndrome and micronodules. The possibility of sarcoidosis was raised. Systemic corticosteroids resulted in improvement of the dyspnoea although it recurred on dose reduction...
November 4, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27823912/-chronic-recurrent-annular-neutrophilic-dermatosis
#5
A Croci-Torti, B Guillot, V Rigau, D Bessis
BACKGROUND: Chronic recurrent annular neutrophilic dermatosis (CRAND) is a rare form of neutrophilic dermatosis characterised by chronic annular progression, histological impairment similar to that seen in Sweet's syndrome and the absence of association with generalised signs, abnormal laboratory values or underlying systemic disease. Herein we report two new cases. PATIENTS AND METHODS: Case n(o) 1. A 41-year-old woman had presented with four annular lesions on the forearms and neckline which she had had for one year...
November 4, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27807761/oral-lichen-sclerosus-a-rare-case-report-and-review-of-the-literature
#6
Helvécio Marangon Júnior, Paulo Eduardo Alencar Souza, Rodrigo Villamarim Soares, Ricardo Santiago Gomez, Gustavo Henrique de Mattos Pereira, Martinho Campolina Rebello Horta
Lichen sclerosus (LS) is a chronic inflammatory mucocutaneous disease that often affects the anogenital area and causes significant discomfort and morbidity. Oral mucosal lesions in LS are extremely rare and might be associated with genital and/or skin manifestations. As a unique manifestation of LS, oral lesions are even more rare, with only 20 cases reported in English-language literature. In reviewing that literature in this paper, we present the case of a 44-year-old white man who sought dental assistance with a complaint of a white spot on his upper lip...
November 2, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27703871/conjunctival-lymphangioma-in-a-4-year-old-girl-revealed-tuberous-sclerosis-complex
#7
Florentina Joyce Freiberg, Erdmute Kunstmann, Thomas König, Juliane Matlach, Daniel Kampik
Background: To present a case of conjunctival lymphangioma in a 4-year-old girl with tuberous sclerosis complex. Methods/results: A 4-year-old girl presented with a relapsing cystic lesion of the bulbar conjunctiva in the right eye with string-of-pearl-like dilation of lymphatic vessels and right-sided facial swelling with mild pain. Best-corrected vision was not impaired. Examination of the skin revealed three hypomelanotic macules and a lumbal Shagreen patch. Magnetic resonance imaging (MRI) findings displayed minimal enhancement of buccal fat on the right side...
2016: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/27688435/lichen-planus-pigmentosus-the-controversial-consensus
#8
REVIEW
Aparajita Ghosh, Arijit Coondoo
A pigmented variant of lichen planus (LP) was first reported from India in 1974 by Bhutani et al. who coined the term LP pigmentosus (LPP) to give a descriptive nomenclature to it. LP has a number of variants, one of which is LPP. This disease has also later been reported from the Middle East, Latin America, Korea, and Japan, especially in people with darker skin. It has an insidious onset. Initially, small, black or brown macules appear on sun-exposed areas. They later merge to form large hyperpigmented patches...
September 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27666661/molecular-screening-strategies-for-nf1-like-syndromes-with-caf%C3%A3-au-lait-macules-review
#9
Jia Zhang, Ming Li, Zhirong Yao
Multiple café-au-lait macules (CALM) are usually associated with neurofibromatosis type 1 (NF1), one of the most common hereditary disorders. However, a group of genetic disorders presenting with CALM have mutations that are involved in human skin pigmentation regulation signaling pathways, including KIT ligand/KIT proto‑oncogene receptor tyrosine kinase and Ras/mitogen‑activated protein kinase. These disorders, which include Legius syndrome, Noonan syndrome with multiple lentigines or LEOPARD syndrome, and familial progressive hyperpigmentation) are difficult to distinguish from NF1 at early stages, using skin appearance alone...
November 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27664712/expanding-the-mutation-spectrum%C3%A2-of%C3%A2-ichthyosis-with-confetti
#10
Young H Lim, Keith A Choate
Ichthyosis with confetti is a rare, autosomal dominant disorder caused by frameshift mutations in KRT10 or KRT1 and characterized by the development of white, genetically revertant macules in red, diseased skin. All cases result from mutations affecting the tail domains of keratin-10 or keratin-1, and Suzuki et al. expand the mutation spectrum for ichthyosis with confetti caused by mutations in KRT1, showing that a polyarginine frameshift in the keratin-1 tail can also cause this disorder.
October 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27635239/recent-advances-in-understanding-vitiligo
#11
REVIEW
Prashiela Manga, Nada Elbuluk, Seth J Orlow
Vitiligo, an acquired depigmentation disorder, manifests as white macules on the skin and can cause significant psychological stress and stigmatization. Recent advances have shed light on key components that drive disease onset and progression as well as therapeutic approaches. Vitiligo can be triggered by stress to the melanin pigment-producing cells of the skin, the melanocytes. The triggers, which range from sunburn to mechanical trauma and chemical exposures, ultimately cause an autoimmune response that targets melanocytes, driving progressive skin depigmentation...
2016: F1000Research
https://www.readbyqxmd.com/read/27634312/levofloxacin-induced-toxic-epidermal-necrolysis-successful-therapy-with-omalizumab-anti-ige-and-pulse-prednisolone
#12
Rusen Uzun, Arzu Didem Yalcin, Betul Celik, Tangul Bulut, Ata Nevzat Yalcin
BACKGROUND Toxic epidermal necrolysis (TEN) is characterized by widespread erythematous and bullous lesions on the skin. Nowadays, considerable progress has been made in the understanding of its pathogenesis. Immunologically it is similar to graft-versus-host disease. Therefore, we may propose that TEN is a disorder of cell-mediated immunity. CASE REPORT Our patient was a 74-year-old white female who had pneumonia and was positive for hepatitis C virus (HCV), and who had been on levofloxacin therapy. After the first levofloxacin dose, erythematous dusky red macules occurred on her extremities and trunk, and on the following day, confluent purpuric lesions tended to run together over 85% of her body...
2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27611178/cutaneous-involvement-of-pre-existing-rosai-dorfman-disease-via-post-herpetic-isotopic-response
#13
Neeta Malviya, Alexander Marzuka, Mokhtar Maamed-Tayeb, Lu Le, Travis Vandergriff
We report the case of a patient with a long-standing history of extranodal, sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and no evidence of original cutaneous involvement as well as a history of herpes zoster of the left flank with post-herpetic neuralgia who went on to develop multiple, round-to-oval, red-brown, atrophic macules and thin papules at the sites of herpes zoster scars on the left flank. Histopathology showed a dense nodular infiltrate of lymphocytes with some plasma cells and numerous large pale-staining histiocytes (S100+/CD68+), consistent with Rosai-Dorfman disease...
December 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27590352/-dermatological-diseases-of-the-male-genital-tract
#14
F-M Köhn
During complete inspection of skin a variety of penile skin alterations may be found. Not all dermatological findings have clinical relevance. Pearly papules and heterotopic sebaceous glands are physiological variations. Most penile melanotic macules, angiokeratoma, fibroma and angioma have not to be treated. However, other more severe diseases such as malignant skin lesions (erythroplasia of Queyrat), infectious disease (human papillomavirus-induced penile warts) or systemic skin diseases (psoriasis) may be detected...
October 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27579541/vitiligo-co-existing-with-lichen-striatus-more-than-a-coincidence
#15
J H Chong, D Mermin, J F Goussot, A Taïeb
A 3 year old girl of West African descent presented with asymptomatic skin lesions on her limbs, face, back and trunk which increased in number over a period of 1 year. She was well-thrived with no significant past medical history nor family history of atopic or autoimmune diseases. Examination showed a linear hypopigmented band in a blaschkoid distribution with a few scattered papules extending from her distal left arm to her anterior shoulder and chest (Fig. 1). There were also linear depigmented streaks which developed after trauma and depigmented macules on her limbs, back, face and trunk (Fig...
August 31, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27547963/epidermal-skin-grafting-in-vitiligo-a-pilot-study
#16
Agata Janowska, Valentina Dini, Salvatore Panduri, Michela Macchia, Teresa Oranges, Marco Romanelli
Vitiligo is a multifactorial acquired dermatosis characterised by achromic or hypochromic macules and by the absence of functioning melanocytes. Treatment depends on the extent of the affected areas and on disease activity. Surgical techniques have proven to be effective in stable cases but can be time-consuming and, in some cases, aesthetically unsatisfying or painful for the patients. The aim of the study was to assess the clinical safety and effectiveness of a new automatic epidermal skin harvesting device in patients with stable localised vitiligo over a minimum 12-month period...
September 2016: International Wound Journal
https://www.readbyqxmd.com/read/27533074/prurigo-pigmentosa-report-of-3-cases-from-brazil-and-literature-review
#17
Thiago Jeunon de Sousa Vargas, Clara Morena Abreu Raposo, Ricardo Barbora Lima, Ana Luisa Sampaio, Ana Beatriz Bordin, Maria Auxiliadora Jeunon Sousa
Prurigo pigmentosa (PP) is a rare inflammatory disease of the skin of uncertain etiology first reported in Japan. It is typified by recurrent eruptions of itching urticarial macules, papules, vesicopapules, and plaques with a reticular arrangement that quickly resolve leaving a net-like pigmentation. The disease presents specific histopathological features. Herein, 3 cases of PP in Brazilians with no Japanese ancestry are reported and a revision of all previous English-language case reports indexed on PubMed is provided...
August 16, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27518244/ruptured-left-external-carotid-artery-aneurysm-presenting-as-upper-airway-obstruction-in-von-recklinghausen-s-disease
#18
Hajar Souldi, Mohammed Yahya Bajja, Meriem Chenguir, RedaLah Abada, Samy Rouadi, Mohammed Roubal, Mohammed Mahtar
INTRODUCTION: Neurofibromatosis type 1 (NF-1) is an autosomal dominant disorder characterized by café-au-lait macules, neurofibromas, and iris hamartomas. Carotid artery aneurysms rarely affect patients with NF-1 but may be associated with rupture. We report the first episode of a ruptured external carotid aneurysm with severe life-threatening airway obstruction in a NF-1 patient. PRESENTATION OF CASE: We report a case of NF-1 32-year-old woman admitted to our department for life-threatening upper airway obstruction caused by spontaneous expanding swelling in the left sided neck...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27512351/prevalence-of-skin-disorders-in-primary-and-secondary-school-age-children-in-canakkale-turkey-a-community-based-survey
#19
Aysegul Uludağ, Sevilay Oguz Kılıc, Selda Isık, Yusuf Haydar Ertekin, Murat Tekin, Sibel Cevizci, Zerrin Ogretmen, Naci Topaloglu, Erkan Melih Sahin, Birol Cıbık
INTRODUCTION: Skin lesions may be of dermatological importance, affect appearance, and cause problems communicating with peers and may be especially more significant in childhood. AIM: Information on the prevalence of pediatric dermatoses in Western Turkey. This study was aimed to define the existing data. MATERIAL AND METHODS: A cross-sectional study was conducted in Canakkale, Turkey, in September-December 2013. It involved 1,957 students from five randomly selected primary and secondary schools...
June 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27506505/a-study-of-the-free-radical-scavenging-effects-of-piper-betle-leaf-extract-in-patients-with-vitiligo
#20
Sneha Mitra, Ayan Kumar Pati, Alak Manna, Arghyaprasun Ghosh, Sumit Sen, Suparna Chatterjee, Mitali Chatterjee
BACKGROUND: Vitiligo is an idiopathic skin disease manifested by depigmented macules. It is characterised by melanocyte destruction, and redox imbalance is proposed to play a contributory role. AIM: The aim of this study was to analyze the effects of an ethanolic extract of Piper betle leaves on the generation of reactive oxygen species in erythrocytes sourced from vitiligo patients. METHODS: The effect of Piper betle on the generation of reactive oxygen species in erythrocytes was measured by flow cytometry in patients with active and stable vitiligo versus healthy controls, using 5-(and-6)-chloromethyl-2'- 7'- dichlorodihydrofluorescein diacetate...
August 4, 2016: Indian Journal of Dermatology, Venereology and Leprology
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