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https://www.readbyqxmd.com/read/28315338/lymphatic-and-vascular-markers-in-an-optic-nerve-crush-model-in-rat
#1
A Trost, D Bruckner, A Kaser-Eichberger, K Motloch, B Bogner, C Runge, C Strohmaier, S Couillard-Despres, H A Reitsamer, F Schroedl
Only few tissues lack lymphatic supply, such as the CNS or the inner eye. However, if the scleral border is compromised due to trauma or tumor, lymphatics are detected in the eye. Since the situation in the optic nerve (ON), part of the CNS, is not clear, the aim of this study is to screen for the presence of lymphatic markers in the healthy and lesioned ON. Brown Norway rats received an unilateral optic nerve crush (ONC) with defined force, leaving the dura intact. Lesioned ONs and unlesioned contralateral controls were analyzed 7 days (n = 5) and 14 days (n = 5) after ONC, with the following markers: PDGFRb (pericyte), Iba1 (microglia), CD68 (macrophages), RECA (endothelial cell), GFAP (astrocyte) as well as LYVE-1 and podoplanin (PDPN; lymphatic markers)...
March 14, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28304388/pirfenidone-inhibits-post-traumatic-proliferative-vitreoretinopathy
#2
B N M K Khanum, R Guha, V P Sur, S Nandi, S K Basak, A Konar, S Hazra
PurposeThe purpose of the study was to evaluate the efficacy and safety of intravitreal pirfenidone for inhibition of proliferative vitreoretinopathy (PVR) in a model of penetrating ocular injury.Patients and methodsPenetrating trauma was induced on the retina of rabbit and treated either with 0.1 ml of phosphate-buffered saline (PBS) or 0.1 ml of 0.5% pirfenidone, and development of PVR was evaluated clinically and graded after 1 month. Histopathology and immunohistochemistry with transforming growth factor beta (TGFβ), alpha smooth muscle actin (αSMA), and collagen-1 were performed to assess the fibrotic changes...
March 17, 2017: Eye
https://www.readbyqxmd.com/read/28303330/ocular-trauma-score-as-prognostic-value-in-traumatic-ocular-injuries-due-to-rotating-wire-brushes
#3
Konstantine Purtskhvanidze, Florian Rüfer, Alexa Klettner, Christoph Borzikowsky, Johann Roider
PURPOSE: Rotating wire brushes are used, e.g., for rust removal. Detaching fragments can cause severe eye injuries. The purpose of this study was to investigate mechanism, severity, clinical outcome, validity of Ocular Trauma Score (OTS) and to assess the likelihood of final visual acuity. METHODS: Twenty patients with traumatic ocular injuries by rotating wire brushes were included. Location and type of injury, grade of injury according to OTS, surgical procedure, and development of visual acuity were evaluated...
March 16, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28302084/effectiveness-of-emdr-in-patients-with-substance-use-disorder-and-comorbid-ptsd-study-protocol-for-a-randomized-controlled-trial
#4
Ingo Schäfer, Laycen Chuey-Ferrer, Arne Hofmann, Peter Lieberman, Günter Mainusch, Annett Lotzin
BACKGROUND: Eye Movement Desensitization and Reprocessing (EMDR) is an evidence-based treatment for PTSD. However, it is unclear whether EMDR shows the same effectiveness in patients with substance use disorders (SUD) and comorbid PTSD. In this trial, we examine the effectiveness of EMDR in reducing PTSD symptoms in patients with SUD and PTSD. METHODS/DESIGN: We conduct a single-blinded RCT among 158 patients with SUD and comorbid PTSD admitted to a German addiction rehabilitation center specialized for the treatment of patients with SUD and comorbid PTSD...
March 16, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28300549/periocular-necrotizing-fasciitis-in-an-infant
#5
Alan D Proia
A 12-month-old boy developed periocular necrotizing fasciitis with swelling of both eyes and redness and a discharge from the left eye approximately 36 hours after blunt trauma. Computed tomography revealed pre-septal and soft tissue edema on the left side, but no signs of orbital involvement, orbital fractures, or drainable abscess in the anterior left lower eyelid. The inflammatory signs worsened over the next day, and there was purulent discharge from the left lower eyelid and an abscess and necrosis of the lower eyelid skin...
March 11, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28298316/paediatric-infectious-keratitis-a-case-series-of-107-children-presenting-to-a-tertiary-referral-centre
#6
Julia Dutra Rossetto, Kara M Cavuoto, Carla J Osigian, Ta Chen Peter Chang, Darlene Miller, Hilda Capo, Oriel Spierer
BACKGROUND/AIMS: Corneal ulcers can result in severe visual impairment in children. The recent trends of paediatric microbial ulcerative keratitis in the USA are unknown. The purpose of this study is to report the risk factors, microbiological profile and treatment outcomes of paediatric microbial keratitis in South Florida. METHODS: A university-based tertiary eye care centre retrospective case series between 1992 and 2015. Medical records of 107 paediatric patients (age <18 years) with the diagnosis of microbial ulcerative keratitis were analysed...
March 15, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28292273/ocular-bacterial-infections-at-quiha-ophthalmic-hospital-northern-ethiopia-an-evaluation-according-to-the-risk-factors-and-the-antimicrobial-susceptibility-of-bacterial-isolates
#7
Mebrahtu Teweldemedhin, Muthupandian Saravanan, Araya Gebreyesus, Dawit Gebreegziabiher
BACKGROUND: External and intraocular infections can lead to visual impairments, which is a major public health problem. Bacteria are the most frequent pathogens affecting ocular structures; the increasing rate of antimicrobial drug resistance is a worldwide concern. The aim of this study was to determine the occurrence of bacteria in ocular infections, their antimicrobial susceptibility patterns, and risk factors in bacterial ocular infection. METHODS: A hospital based cross-sectional study was conducted from September 2015 to December 2015 at Quiha Ophthalmic Hospital, Tigray, northern Ethiopia...
March 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28291481/self-reported-visual-quality-of-life-after-combat-ocular-trauma
#8
Andrew McLaughlin, Marcus H Colyer, Denise S Ryan, Rose K Sia, Eric D Weichel, Andrew Spiegelman, S G Eaddy, Robert A Mazzoli, Kraig S Bower
OBJECTIVES: To describe the visual outlook and quality of life of service members after combat ocular trauma. METHODS: In a single-center, prospective observational study of service members sustaining ocular trauma, participants underwent a series of ocular examinations and noninvasive tests, including the National Eye Institute Visual Functioning Questionnaire (VFQ-25). RESULTS: Of the 165 enrolled participants, 137 completed the VFQ-25. The mean VFQ-25 composite score was 74...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28291478/blast-wave-dynamics-at-the-cornea-as-a-function-of-eye-protection-form-and-fit
#9
Steven T Williams, Thomas H Harding, J Keegan Statz, John S Martin
A shock tube and anthropomorphic headforms were used to investigate eye protection form and fit using eyewear on the Authorized Protective Eyewear List in primary ocular blast trauma experiments. Time pressure recordings were obtained from highly linear pressure sensors mounted at the cornea of instrumented headforms of different sizes. A custom shock tube produced highly reliable shock waves and pressure recordings were collected as a function of shock wave orientation and protective eyewear. Eyewear protection coefficients were calculated as a function of a new metric of eyewear fit...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28291461/corneal-and-corneoscleral-injury-in-combat-ocular-trauma-from-operations-iraqi-freedom-and-enduring-freedom
#10
Anton Vlasov, Denise S Ryan, Spencer Ludlow, Andrew Coggin, Eric D Weichel, Richard D Stutzman, Kraig S Bower, Marcus H Colyer
OBJECTIVES: To examine the incidence and the etiology of corneal and corneoscleral injuries in the setting of combat ocular trauma, and to determine what effect these injuries have on overall visual impairment from combat ocular trauma. METHODS: Retrospective, noncomparative, interventional case series, analyzing U.S. service members who were evacuated to the former Walter Reed Army Medical Center (WRAMC). Primary outcome measures were types of corneal injuries, length of follow-up at WRAMC, globe survival, and anatomical causes of blindness...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28289914/firecracker-eye-exposure-experimental-study-and-simulation
#11
Chiara Clemente, Luca Esposito, Domenico Speranza, Nicola Bonora
Understanding the mechanisms of traumatic ocular injury is helpful to make accurate diagnoses before the symptoms emerge and to develop specific eye protection. The comprehension of the dynamics of primary blast injury mechanisms is a challenging issue. The question is whether the pressure wave propagation and reflection alone could cause ocular damage. To date, there are dissenting opinions and no conclusive evidence thereupon. A previous numerical investigation of blast trauma highlighted the dynamic effect of pressure propagation and its amplification by the geometry of the bony orbit, inducing a resonance cavity effect and a standing wave hazardous for eye tissues...
March 13, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28288588/siderotic-cataract-with-no-signs-of-intraocular-foreign-body
#12
Ke-Ke Zhang, Wen-Wen He, Yi Lu, Xiang-Jia Zhu
BACKGROUND: Ocular siderosis is a clinical condition induced by deposition of an iron-containing intraocular foreign body. We report a unique case of histopathologically proven lens siderosis in a young woman with a preceding history of trauma but no signs of retained intraocular foreign body. CASE PRESENTATION: A 32-year-old woman presented with an opacified lens showing brownish deposits on the anterior capsule and underwent cataract surgery. Preoperative ophthalmic examination did not show any retained intraocular foreign body...
March 14, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28286849/isolated-oculomotor-nerve-palsy-following-minor-head-trauma-a-case-report
#13
Iraj GoliKhatir, Hamed Aminiahidashti, Hasan Motamed Motlagh, Seyed Farshad Heidari
Isolated third nerve palsy develops in numerous intracranial pathologies such as closed head trauma, tumor, and aneurysm. This report describes a 61 years old female with an abrasion on the left forehead and ptosis of the left eye. Initial computed tomography did not reveal any causative cerebral and vascular lesions or orbital and cranial fractures. High-resolution and multi-axial enhanced Magnetic resonance imaging (MRI) can be helpful in diagnosis and monitoring of patients with this rare phenomenon.
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28282696/analysis-of-ocular-firework-related-injuries-and-common-eye-traumata-a-5-year-clinical-study
#14
S Frimmel, O M Theusinger, C Kniestedt
Background A comparative study of eye injuries related to fireworks or acts of violence around New Year's Eve and the Swiss National Day on August 1st. The two groups were compared with respect to the overall numbers of eye accidents within the period of review. Patients and Methods Retrospective analysis of emergency consultations at the Department of Ophthalmology, University Hospital Zurich with eye accidents around the Swiss National Day on August 1st and New Year's Eve over the last 5 years. Two subgroups were formed: (1) Firework-related eye traumata, (2) Eye injuries due to acts of violence...
March 10, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28280709/chemosis-as-complication-in-transconjunctival-approach-for-orbital-trauma
#15
Sergio Olate, Celso Palmieri, Márcio de Moraes
The aim of this report was to discuss a complication resulting from a transconjunctival approach to treating an orbital fracture. A 30-year-old male patient presented with a fracture to the zygomatic orbital complex. He was treated with transconjunctival conventional surgical treatment. Two days after surgical treatment, the patient presented with secondary chemosis which was initially slight and then subsequently worsened. The clinical situation was managed with topical and systemic corticosteroids and resolved within one postoperative month...
February 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28275602/occult-fungal-scleritis
#16
Lauren J Jeang, Aaron Davis, Brian Madow, Edgar M Espana, Curtis E Margo
PURPOSE: To heighten awareness of occult fungal scleritis. METHOD: Case report and review of the literature. RESULTS: A 73-year-old woman with diabetes mellitus was diagnosed for 3 months with immune-mediated scleritis and subsequently treated with corticosteroids. On referral, the patient had a scleral nodule with contiguous corneal infiltrate and hypopyon. Culture grew Fusarium species not further classified. The infection could not be controlled with antifungal therapy, and the eye was removed...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28274942/socioeconomic-deprivation-and-serious-ocular-trauma-in-scotland-a-national-prospective-study
#17
Liying Low, James Hodson, Daniel Morris, Parul Desai, Caroline MacEwen
OBJECTIVE: To identify the population at risk of serious ocular trauma by exploring relationships with socioeconomic factors. DESIGN: National, prospective, population-based, cross-sectional and follow-up study. PARTICIPANTS: Patients with serious ocular trauma requiring hospital admission in Scotland. METHODS: Case definition and ascertainment-cases of serious ocular trauma necessitating admission to hospital under the care of a consultant ophthalmologist were identified using the British Ophthalmological Surveillance Unit reporting scheme...
March 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28272016/cactus-spine-wounds-a-case-report-and-short-review-of-the-literature
#18
Raymond A Dieter, Lisa R Whitehouse, Rebecca Gulliver
INTRODUCTION: Cactus plants are commonly seen in arid southwestern regions of the United States. Due to their ready availability, they have become a popular houseplant. The spines or glochidia can easily puncture the skin with only minor pressure (ie, bumping or touching the cactus). Removal of the offending spine is difficult, even with tweezers. CASE: An 18-year-old woman initially self-removed the spines, and marked discomfort and intense erythematous reaction developed within 8 to 10 hours...
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28271013/ultrahigh-resolution-oct-imaging-of-the-human-cornea
#19
René M Werkmeister, Sabina Sapeta, Doreen Schmidl, Gerhard Garhöfer, Gerald Schmidinger, Valentin Aranha Dos Santos, Gerold C Aschinger, Isabella Baumgartner, Niklas Pircher, Florian Schwarzhans, Anca Pantalon, Harminder Dua, Leopold Schmetterer
We present imaging of corneal pathologies using optical coherence tomography (OCT) with high resolution. To this end, an ultrahigh-resolution spectral domain OCT (UHR-OCT) system based on a broad bandwidth Ti:sapphire laser is employed. With a central wavelength of 800 nm, the imaging device allows to acquire OCT data at the central, paracentral and peripheral cornea as well as the limbal region with 1.2 µm x 20 µm (axial x lateral) resolution at a rate of 140 000 A-scans/s. Structures of the anterior segment of the eye, not accessible with commercial OCT systems, are visualized...
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28269417/robot-assisted-retinal-vein-cannulation-with-force-based-puncture-detection-micron-vs-the-steady-hand-eye-robot
#20
Berk Gonenc, Nhat Tran, Peter Gehlbach, Russell H Taylor, Iulian Iordachita
Retinal vein cannulation is a demanding procedure where therapeutic agents are injected into occluded retina veins. The feasibility of this treatment is limited due to challenges in identifying the moment of venous puncture, achieving cannulation and maintaining it throughout the drug delivery period. In this study, we integrate a force-sensing microneedle with two distinct robotic systems: the handheld micromanipulator Micron, and the cooperatively controlled Steady-Hand Eye Robot (SHER). The sensed tool-to-tissue interaction forces are used to detect venous puncture and extend the robots' standard control schemes with a new position holding mode (PHM) that assists the operator hold the needle position fixed and maintain cannulation for a longer time with less trauma on the vasculature...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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