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Coal worker pneumoconiosis

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https://www.readbyqxmd.com/read/29732582/continued-increase-in-lung-transplantation-for-coal-workers-pneumoconiosis-in-the-united-states
#1
David J Blackley, Cara N Halldin, A Scott Laney
BACKGROUND: Severe coal workers' pneumoconiosis (CWP) is increasingly common, and sometimes requires lung transplantation. METHODS: Using Organ Procurement and Transplantation Network data, we updated the trend for CWP-related lung transplants, described CWP patients who have been waitlisted but not transplanted, and characterized the primary payer of medical costs for CWP-related and other occupational lung disease transplants. RESULTS: There have been at least 62 CWP-related lung transplants; 49 (79%) occurred in the last decade...
May 6, 2018: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/29642880/prevalence-of-latent-tuberculosis-infection-among-coal-workers-pneumoconiosis-patients-in-china-a-cross-sectional-study
#2
Yan Jin, Huanqiang Wang, Jianfang Zhang, Chunguang Ding, Ke Wen, Jingguang Fan, Tao Li
BACKGROUND: Little is known about the prevalence of latent tuberculosis infection (LTBI) among coal workers' pneumoconiosis (CWP) patients. To estimate the prevalence of LTBI and identify its associated risk factors among CWP patients. METHODS: A cross-sectional study was conducted to assess the prevalence of LTBI. Participants were screened for active TB or a history of TB by X-ray and those that underwent QuantiFERON-TB Gold In-Tube (QFT) test. A standardized questionnaire was completed and risk factors were assessed for acquiring TB...
April 11, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29563194/establishment-and-application-of-an-index-system-for-prevention-of-coal-workers-pneumoconiosis-a-delphi-and-analytic-hierarchy-process-study-in-four-state-owned-coal-enterprises-of-china
#3
Kai Cui, Fuhai Shen, Bing Han, Hongbo Liu, Jie Chen
OBJECTIVE: To explore the difference of cumulative incidence rate of coal workers' pneumoconiosis (CWP) among four large state-owned coal enterprises in northern China, we created an index system for evaluating the quality of comprehensive measures against CWP and applied the system to evaluate and compare the measures of the four coal enterprises. METHODS: A two-round Delphi investigation was conducted to identify the indicators in the index system. The weight values of the indicators were calculated with analytic hierarchy process methods...
March 21, 2018: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29465110/james-craufurd-gregory-19th-century-scottish-physicians-and-the-link-between-occupation-as-a-coal-miner-and-lung-disease
#4
K Donaldson, W A Wallace, T A Elliot, C Henry
By the mid-19th century about 200,000 miners were employed in a UK coal mining industry still growing with the advances of the Industrial Revolution. Coal miners were long known to suffer poor health but the link to inhaling dust in the mines had not been made. In 1813 George Pearson was the first to suggest that darkening of lungs seen in normal individuals as they aged was caused by inhaled soot from burning oil, candles and coal, which were the common domestic sources of heat and light. In 1831 Dr James Craufurd Gregory first described black pigmentation and disease in the lungs of a deceased coal miner and linked this to pulmonary accumulation of coal mine dust...
September 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29438277/a-response-to-the-comment-on-tomaskova-et-al-mortality-in-miners-with-coal-workers-pneumoconiosis-in-the-czech-republic-in-the-period-1992-2013-int-j-environ-res-public-health-2017-14-269-by-the-author-mei-yong
#5
Hana Tomášková, Anna Šplíchalová, Hana Šlachtová, Daniela Pelclová, Pavel Urban, Zdeněk Jirák
At first, we would like to thank Mei Yong for the comments on our article Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013 [...].
February 13, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29416696/tnfr-tnf-%C3%AE-signaling-pathway-regulates-apoptosis-of-alveolar-macrophages-in-coal-workers-pneumoconiosis
#6
Qing-Zeng Qian, Xiang-Ke Cao, Hai-Yan Liu, Guo-Ying Zheng, Qing-Qiang Qian, Fu-Hai Shen
We explored the role of TNFR/TNF-α signalingin apoptosis among alveolar macrophages (AM) and its relevance to the development of coal workers' pneumoconiosis (CWP). Purified alveolar macrophages (AMs) were prepared from bronchoalveolar lavage fluid harvested from 366 CWP patients and 120 healthy subjects enrolled inthe study. The purified AMs were then divided into control, SOD, anti-TNFR, TNFR and NFkB inhibitor groups and analyzed for apoptosis usingflow cytometry (sub-diploid peak) and western blotting (Bcl-2, Caspase-3 and Caspase-8 expression)...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415464/comment-on-tomaskova-et-al-mortality-in-miners-with-coal-workers-pneumoconiosis-in-the-czech-republic-in-the-period-1992-2013-int-j-environ-res-public-health-2017-14-269
#7
Mei Yong
With interest, I read the recent analysis by Tomaskova and co-workers (2017) about mortality from coal workers' pneumoconiosis (CWP). The research question remains unclear whether coal workers' pneumoconiosis (CWP) resulting from exposure to respirable coal dust containing crystalline silica accelerates the development of lung cancer or whether it is an intermediate stage in the pathway. I made several points of considerations with respect to (1) qualified data; (2) alternate measures for excessive risks; and (3) methodological flaws that should be avoided...
February 6, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29394417/association-analysis-identifies-new-risk-loci-for-coal-workers-pneumoconiosis-in-han-chinese-men
#8
Ting Wang, Yan Li, Meng Zhu, Wenxi Yao, Hongyan Wu, Xiaoming Ji, Zhibin Hu, Hongbing Shen, Xiangshan Fan, Chunhui Ni
Coal worker's pneumoconiosis (CWP) is a debilitating and progressive occupational lung disease resulted from long-term inhalation of airborne silica-containing coal mine dust. Both environmental factors and genetic variations contribute to CWP. Our previous genome-wide association study (GWAS) revealed a tiny fraction of variants with the top associations in Chinese Han population. To identify novel susceptibility loci of CWP, functional variants with suboptimal associations in the GWAS scan were further studied here...
January 31, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29294518/-study-of-the-association-between-interleukin-1-polymorphisms-and-genetic-susceptibility-of-coal-workers-pneumoconiosis-and-silicosis
#9
W Wang, W H Zhang, Y S Tao, X Zhuang, M J Chu
Objective: To evaluate the relationship between IL-1 gene polymorphisms and coal workers' pneumoconiosis and silicosis susceptibility. Methods: We searched published full-text from PubMed, Web of Science, CNKI, VIP and Wanfang to collect case-control study on IL-1 gene polymorphisms with coal workers' pneumoconiosis and silicosis susceptibility. Eight articles, including 10 case-control studies were included in our study. All analyses were performed using the Stata version 12.0 software. Results: The IL-1RA (+2018) TC or CC variant genotypes were associated with coal workers' pneumoconiosis and silicosis risk ( OR =1...
September 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29157141/experimental-study-on-effects-of-drilling-parameters-on-respirable-dust-production-during-roof-bolting-operations
#10
Hua Jiang, Yi Luo, Joe McQuerrey
Underground coalmine roof bolting operators exhibit a continued risk for overexposure to airborne levels of respirable coal and crystalline silica dust from the roof drilling operation. Inhaling these dusts can cause coal worker's pneumoconiosis and silicosis. This research explores the effect of drilling control parameters, specifically drilling bite depth, on the reduction of respirable dust generated during the drilling process. Laboratory drilling experiments were conducted and results demonstrated the feasibility of this dust control approach...
February 2018: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29116190/estimated-economic-costs-of-coal-workers-pneumoconiosis-among-coal-workers-redeployed-from-the-fuxin-mining-group-in-china
#11
Bing Han, Hongbo Liu, Guojiang Zhai, Qun Wang, Jie Liang, Mengcang Zhang, Kai Cui, Fuhai Shen, Hongbo Yi, Jie Chen
Our research estimated the economic costs of possible cases of coal workers' pneumoconiosis (CWP) among redeployed coal workers from the Fuxin Mining Industry Group. The study cohort included 19,116 coal workers between 1965 and 2012. We estimated direct and indirect economic costs due to possible current and future CWP cases among redeployed coal workers. We found as of 2012 that 141 possible CWP cases might have resulted in economic costs of $37.52 million ($33.84 million were direct and $3.68 million indirect)...
February 2018: Journal of Public Health Policy
https://www.readbyqxmd.com/read/29081110/-coal-workers-s-pneumoconiosis-combined-with-invasive-pulmonary-aspergillosis-a-case-report
#12
Y R Wang, Q Ye
No abstract text is available yet for this article.
July 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29081100/-the-clinical-study-on-the-correlation-of-lysophosphatidic-acid-and-vascular-endotheli-growth-factor-and-endothelin-in-serum-of-pneumoconiosis
#13
L J Mao, Y L Zhang, C C Cong, L Guan, S Q Li, J Y Zhao
Objective: To explore the role of lysophosphatidic acid, vascular endothelial growth facor and endothelin in the pathogenesis of pulmonary fibrosis in coal workers'pneumoconiosis patients, the relationship of lysophosphatidic acid, VEGF and ET in serum was studied. Methods: Sixty two pneumoconiosis patients were selected as cases group, which included 23 cases of stage Ⅰ, 25 cases of stageⅡand 14 cases of stageⅢ. Twenty workers were selected as dust exposure group who exposed to coal dust for more than 2 years and had not been diagnosed as pneumoconiosis...
July 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28953250/lrba-gene-polymorphisms-and-risk-of-coal-workers-pneumoconiosis-a-case-control-study-from-china
#14
Yi Liu, Jingjin Yang, Qiuyun Wu, Ruhui Han, Weiwen Yan, Jiali Yuan, Xiaoming Ji, Yan Li, Wenxi Yao, Chunhui Ni
The lipopolysaccharide (LPS)-responsive beige-like anchor protein (LRBA) is a member of the WDL-BEACH-WD (WBW) gene family. Defects in this gene are associated with the disordered autoimmunity in various diseases, including pulmonary fibrosis. In this study, we investigated the association between the functional polymorphisms in LRBA and risk of coal workers' pneumoconiosis (CWP) in a Chinese population. Three potentially functional polymorphisms (rs2290846, rs3749574, and rs1782360) in LRBA were genotyped and analyzed in a case-control study, including 703 CWP cases and 705 controls...
September 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28844669/polymorphisms-in-autophagy-related-genes-and-the-coal-workers-pneumoconiosis-in-a-chinese-population
#15
Jiali Yuan, Ruhui Han, Ayaaba Esther, Qiuyun Wu, Jingjin Yang, Weiwen Yan, Xiaoming Ji, Yi Liu, Yan Li, Wenxi Yao, Chunhui Ni
Autophagy is an evolutionary conserved intracellular degradation/recycling system that is essential for cellular homeostasis. Dysregulation of this process leads to a number of disorders, including pulmonary fibrosis. However, the genetic association between singe nucleotide polymorphisms of autophagy related genes (ATGs) and the risk of coal workers' pneumoconiosis has not been reported yet. Total of 7 SNPs in ATGs (ATG16, ATG12, ATG5, ATG10) were investigated for their roles in CWP by a case-control study which including 705 CWP patients and 703 control subjects...
October 20, 2017: Gene
https://www.readbyqxmd.com/read/28801410/radiographic-features-of-importance-in-the-national-institute-for-occupational-safety-and-health-administered-coal-workers-health-surveillance-program-characterising-the-use-of-the-other-symbols
#16
Cara N Halldin, Janet M Hale, David J Blackley, A Scott Laney
OBJECTIVE: The National Institute for Occupation Safety and Health-administered Coal Workers' Health Surveillance Program (CWHSP) provides radiographic pneumoconiosis screening for US coal miners. Radiographs are classified by readers according to International Labour Office criteria. In addition to pneumoconiotic parenchymal and pleural lung abnormalities, readers document radiographic features of importance (other symbols). Other symbols are not meant to imply a diagnosis or interpretation but are relevant as they provide information beyond a pneumoconiosis classification for features related to dust exposure and other aetiologies...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28766124/human-lung-injury-following-exposure-to-humic-substances-and-humic-like-substances
#17
REVIEW
Andrew J Ghio, Michael C Madden
Among the myriad particles the human respiratory tract is exposed to, a significant number are distinctive in that they include humic substances (HS) and humic-like substances (HULIS) as organic components. HS are heterogeneous, amorphous, organic materials which are ubiquitous occurring in all terrestrial and aqueous environments. HULIS are a complex class of organic, macromolecular compounds initially extracted from atmospheric aerosol particles which share some features with HS including an aromatic, polyacidic nature...
April 2018: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28698398/tnfr-tnf-%C3%AE-signaling-pathway-regulates-apoptosis-of-alveolar-macrophages-in-coal-workers-pneumoconiosis
#18
Qing-Zeng Qian, Xiang-Ke Cao, Hai-Yan Liu, Guo-Ying Zheng, Qing-Qiang Qian, Fu-Hai Shen
We explored the role of TNFR/TNF-α signalingin apoptosis among alveolar macrophages (AM) and its relevance to the development of coal workers' pneumoconiosis (CWP). Purified alveolar macrophages (AMs) were prepared from bronchoalveolar lavage fluid harvested from 366 CWP patients and 120 healthy subjects enrolled inthe study. The purified AMs were then divided into control, SOD, anti-TNFR, TNFR and NFkB inhibitor groups and analyzed for apoptosis usingflow cytometry (sub-diploid peak) and western blotting (Bcl-2, Caspase-3 and Caspase-8 expression)...
July 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28689212/coal-mine-dust-desquamative-chronic-interstitial-pneumonia-a-precursor-of-dust-related-diffuse-fibrosis-and-of-emphysema
#19
Tomislav M Jelic, Oscar C Estalilla, Phyllis R Sawyer-Kaplan, Milton J Plata, Jeremy T Powers, Mary Emmett, John T Kuenstner
BACKGROUND: Diseases associated with coal mine dust continue to affect coal miners. Elucidation of initial pathological changes as a precursor of coal dust-related diffuse fibrosis and emphysema, may have a role in treatment and prevention. OBJECTIVE: To identify the precursor of dust-related diffuse fibrosis and emphysema. METHODS: Birefringent silica/silicate particles were counted by standard microscope under polarized light in the alveolar macrophages and fibrous tissue in 25 consecutive autopsy cases of complicated coal worker's pneumoconiosis and in 21 patients with tobacco-related respiratory bronchiolitis...
July 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28598937/increasing-severity-of-pneumoconiosis-among-younger-former-us-coal-miners-working-exclusively-under-modern-dust-control-regulations
#20
Judith M Graber, Gerald Harris, Kirsten S Almberg, Cecile S Rose, Edward L Petsonk, Robert A Cohen
BACKGROUND: Coal workers' pneumoconiosis (CWP) steadily declined among US miners following dust control regulations in 1970. In 2000, severe forms of this disease reemerged among young miners, and are well described among working-but not former-miners. METHODS: Black lung benefits program (BLBP) data (2001 to 2013) were used to estimate respiratory disease burden among former miners including: (1) CWP (simple; advanced CWP, and progressive massive fibrosis [CWP/PMF]); and (2) respiratory impairment (FEV1 percent reference: mild, moderate, ≥moderately-severe)...
June 2017: Journal of Occupational and Environmental Medicine
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