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https://www.readbyqxmd.com/read/27685924/high-incidence-of-thyroid-cancer-among-patients-with-acromegaly
#1
Dimitrios Kaldrymidis, Georgios Papadakis, Georgios Tsakonas, Philippos Kaldrymidis, Theofanis Flaskas, Andreas Seretis, Eleni Pantazi, Ifigenia Kostoglou-Athanassiou, Melpomeni Peppa, Paraskevi Roussou, Evanthia Diamanti-Kandarakis
PURPOSE: Several studies have suggested that patients with acromegaly have an increased risk of thyroid, colorectal, breast and prostate cancers. In this study we determined the prevalence of malignant neoplasms in patients with acromegaly. METHODS: Cancer risk was evaluated in a cohort of 110 patients (M/F 48/62, age 58.63±13.8 years, range 30-86) with acromegaly. Mean age at diagnosis of acromegaly was 46.37±13.11 years. Mean period of time since diagnosis of acromegaly was 12...
July 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27486968/association-between-dietary-nitrate-and-nitrite-intake-and-sitespecific-cancer-risk-evidence-from-observational-studies
#2
Li Xie, Miao Mo, Hui-Xun Jia, Fei Liang, Jing Yuan, Ji Zhu
Epidemiological studies have reported inconsistent findings on the association between dietary nitrate and nitrite intake and cancer risk. We performed a meta-analysis of epidemiological studies to summarize available evidence on the association between dietary nitrate and nitrite intake and cancer risk from published prospective and case-control studies. PubMed database was searched to identify eligible publications through April 30th, 2016. Study-specific relative risks (RRs) with corresponding 95% confidence interval (CI) from individual studies were pooled by using random- or fixed- model, and heterogeneity and publication bias analyses were conducted...
July 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27484217/the-incidence-and-mortality-of-major-cancers-in-china-2012
#3
Wanqing Chen, Rongshou Zheng, Hongmei Zeng, Siwei Zhang
BACKGROUND: The National Central Cancer Registry (NCCR) collected population-based cancer registration data in 2012 from local registries and estimated the cancer incidence and mortality in China. METHODS: In the middle of 2015, 261 cancer registries submitted reports on new cancer cases and deaths occurred in 2012. Qualified data from 193 registries were used for analysis after evaluation. Crude rates, number of cases, and age-standardized rates stratified by area (urban/rural), sex, age group, and cancer type were calculated according to the national population in 2012...
2016: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/27446351/role-of-periostin-in-esophageal-gastric-and-colon-cancer
#4
Tadeusz Moniuszko, Andrzej Wincewicz, Mariusz Koda, Izabela Domysławska, Stanisław Sulkowski
Periostin, also known as osteoblast-specific factor 2, is a cell-adhesion protein with pleiotropic properties. The protein serves a vital role in the maintenance and development of tooth and bone tissue, in addition to cardiac development and healing. Periostin levels are increased in several forms of cancer, including pancreatic, ovarian, colon, lung, breast, gastric, thyroid, and esophageal head and neck carcinomas. The present review highlights the key role of periostin in tumorigenesis, particularly in increasing cell survival, invasion, angiogenesis, epithelial-mesenchymal transition and metastasis of carcinoma cells by interacting with numerous cell-surface receptors, including integrins, in the phosphoinositide 3-kinase-Akt pathway...
August 2016: Oncology Letters
https://www.readbyqxmd.com/read/26622742/piwil2-modulates-the-invasion-and-metastasis-of-prostate-cancer-by-regulating-the-expression-of-matrix-metalloproteinase-9-and-epithelial-mesenchymal-transitions
#5
Yanfeng Yang, Xuepei Zhang, Dongkui Song, Jinxing Wei
Piwi-like RNA-mediated gene silencing 2 (Piwil2) is an oncogene that is highly expressed in breast, gastric, colorectal and papillary thyroid cancer. As a candidate oncogene, its role in prostrate cancer has yet to be elucidated. In the present study, 30 tumor specimens and four prostate cancer cell lines were analyzed. The total RNA and protein from the specimens and the cells were analyzed using quantitative polymerase chain reaction and western blotting, respectively. The expression of Piwil2 in PC-3 cells was knocked down using specific small hairpin RNA...
September 2015: Oncology Letters
https://www.readbyqxmd.com/read/26414866/differential-protein-expression-and-oncogenic-gene-network-link-tyrosine-kinase-ephrin-b4-receptor-to-aggressive-gastric-and-gastroesophageal-junction-cancers
#6
Britta Liersch-Löhn, Nadia Slavova, Heinz J Buhr, Idriss M Bennani-Baiti
Transmembrane tyrosine-kinase Ephrin receptors promote tumor progression and/or metastasis of several malignancies including leukemia, follicular lymphoma, glioma, malignant pleural mesothelioma, papillary thyroid carcinoma, sarcomas and ovarian, breast, bladder and non-small cell lung cancers. They also drive intestinal stem cell proliferation and positioning, control intestinal tissue boundaries and are involved in liver, pancreatic and colorectal cancers, indicating involvement in additional digestive system malignancies...
March 1, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/26349957/papillary-thyroid-carcinoma-ptc-in-lynch-syndrome-report-of-two-cases-and-discussion-on-lynch-syndrome-behaviour-and-genetics
#7
M R Pelizzo, G Pennelli, M Zane, F Galuppini, P M Colletti, I Merante Boschin, D Rubello
We present here two cases of papillary thyroid carcinoma (PTC) in patients affected by Lynch syndrome (LS). The first case is a 47-year-old woman with typical hereditary non-polyposis colorectal cancer (HNPCC) syndrome, reported with endometrial and ovarian carcinoma at age 43, and colon cancer at age 45. The patient underwent total thyroidectomy and central node dissection in 2007, at 47years old, with a histological diagnosis of PTC (T1aN1a). Molecular genetics showed a germ-line mutation of the MLH1 gene, 1858 G>T(E620X), with substitution of glycine with a stop codon at position 620...
August 2015: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/26048190/annexin-a4-and-cancer
#8
REVIEW
Bin Wei, Chunmei Guo, Shuqing Liu, Ming-Zhong Sun
Annexin A4 (Anxa4) is one of the Ca(2+)-regulated and phospholipid-binding annexin superfamily proteins. Anxa4 has a potential role in diagnosis, prognosis, and treatment of certain cancers. Studies indicate that Anxa4 up-regulation promotes the progression of tumor and chemoresistance of colorectal cancer (CRC), esophageal squamous cell carcinoma (ESCC), endometrial carcinoma (EC), gastric cancer (GC), chemoresistant lung cancer (LC), malignant mesothelioma (MM), renal cell carcinoma (RCC), ovarian clear cell carcinoma (OCCC), cholangiocarcinoma, hepatocellular carcinoma (HCC), breast cancer (BC), and laryngeal cancer...
July 20, 2015: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/26038827/correlation-between-the-uptake-of-18f-fluorodeoxyglucose-18f-fdg-and-the-expression-of-proliferation-associated-antigen-ki-67-in-cancer-patients-a-meta-analysis
#9
Sheng-Ming Deng, Wei Zhang, Bin Zhang, Yin-Yin Chen, Ji-Hui Li, Yi-Wei Wu
OBJECTIVE: To study the correlation between 18F-FDG uptake and cell proliferation in cancer patients by meta-analysis of published articles. METHODS: We searched PubMed (MEDLINE included), EMBASE, and Cochrane Database of Systematic Review, and selected research articles on the relationship between 18F-FDG uptake and Ki-67 expression (published between August 1, 1994-August 1, 2014), according to the literature inclusion and exclusion criteria. The publishing language was limited to English...
2015: PloS One
https://www.readbyqxmd.com/read/25946974/nicotinamide-phosphorybosiltransferase-overexpression-in-thyroid-malignancies-and-its-correlation-with-tumor-stage-and-with-survivin-survivin-dex3-expression
#10
COMPARATIVE STUDY
Nadia Sawicka-Gutaj, Joanna Waligórska-Stachura, Mirosław Andrusiewicz, Maciej Biczysko, Jerzy Sowiński, Jerzy Skrobisz, Marek Ruchała
Nicotinamide phosphorybosiltransferase (NAMPT) plays an important role in the regulation of cellular growth, angiogenesis, and apoptosis in mammalian cells. NAMPT overexpression has been recently found in colorectal, breast, prostatic, gastric, esophageal, pancreatic cancers, and specific NAMPT inhibitors might be adjuvant therapeutic modalities. In this study, we analyzed NAMPT expression in 40 malignant and in 67 benign thyroid tissue samples using qPCR. We also investigated relationships between NAMPT expression and survivin/survivin splicing variants DEx3 and 2B expressions...
September 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/25169130/copy-number-alterations-of-chromosomal-regions-enclosing-protein-tyrosine-phosphatase-receptor-like-genes-in-colorectal-cancer
#11
Izabela Laczmanska, Pawel Karpinski, Joanna Kozlowska, Marek Bebenek, David Ramsey, Tomasz Sedziak, Piotr Ziolkowski, Maria M Sasiadek
Protein tyrosine phosphatases that act in different cellular pathways are described most commonly as tumor suppressors, but also as oncogenes. Their role has previously been described in colorectal cancer, as well as in gastric, breast, thyroid, prostate, ovarian, pancreatic, glioma, liver, leukemia and many other cancers. In a previous study, we have described protein tyrosine phosphatase receptor type T, M, Z1 and Q genes (PTPRT, PTPRM, PTPRZ1 and PTPRQ) hypermethylated in sporadic colorectal cancer. Thus, in this study, we examined the relation of unbalanced chromosomal alterations within regions covering these four protein tyrosine phosphatase genes with this cancer...
December 2014: Pathology, Research and Practice
https://www.readbyqxmd.com/read/25091112/significantly-increased-monounsaturated-lipids-relative-to-polyunsaturated-lipids-in-six-types-of-cancer-microenvironment-are-observed-by-mass-spectrometry-imaging
#12
Shuai Guo, Yanmin Wang, Dan Zhou, Zhili Li
Six different types of cancer (i.e., breast, lung, colorectal, esophageal, gastric, and thyroid cancer) have high rates of incidence or mortality worldwide. It has been shown that activation of de novo lipogenesis is an early and common event in the cancer microenvironment. In this study, we performed lipid imaging and profiling for 134 tissue samples from six different types of cancer using matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry, with 2,5-dihydroxybenzoic acid and 1,8-bis(dimethyl-amino)naphthalene as matrices in the positive and negative ion modes, respectively...
2014: Scientific Reports
https://www.readbyqxmd.com/read/24915871/history-of-chronic-comorbidity-and-risk-of-chemotherapy-induced-febrile-neutropenia-in-cancer-patients-not-receiving-g-csf-prophylaxis
#13
C Chao, J H Page, S-J Yang, R Rodriguez, J Huynh, V M Chia
BACKGROUND: Chemotherapy-induced febrile neutropenia (FN) is a clinically important complication that affects patient outcome by delaying chemotherapy doses or reducing dose intensity. Risk of FN depends on chemotherapy- and patient-level factors. We sought to determine the effects of chronic comorbidities on risk of FN. DESIGN: We conducted a cohort study to examine the association between a variety of chronic comorbidities and risk of FN in patients diagnosed with six types of cancer (non-Hodgkin lymphoma and breast, colorectal, lung, ovary, and gastric cancer) from 2000 to 2009 who were treated with chemotherapy at Kaiser Permanente Southern California, a large managed care organization...
September 2014: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/24354961/behcet-s-disease-associated-with-malignancy-a-report-of-41-chinese-cases
#14
Yi Lin, Guohua Li, Wenjie Zheng, Xinping Tian, Fengchun Zhang
OBJECTIVE: To identify the clinical characteristics of Behcet's disease (BD) associated with malignancies. METHOD: Among 651 BD patients sequentially hospitalized in Peking Union Medical College Hospital from 1995 to 2012, 41 patients developed malignancies. Clinical characteristics were compared between patients with and without malignancies, as well as between patients with hematological and solid malignancies. RESULTS: The numbers of patients with various types of malignancies were listed as follows: (i) 29 cases developed hematologic malignancies which included myelodysplastic syndrome (MDS) as the most common diagnosis in 20 cases, leukemia in seven cases, anaplastic anemia in two cases and lymphoma in one case; (ii) 13 cases developed malignant solid neoplasms which included colorectal cancer in three cases, urothelial carcinoma of bladder in two cases, esophageal cancer, gastric cancer, pancreatic cancer, thyroid cancer, breast cancer, cervical cancer, renal cell carcinoma and metastatic adenocarcinoma of unknown primary in one case each...
May 2014: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/24304949/-incidence-and-mortality-of-cancer-in-zhejiang-province-in-2009
#15
Hui-zhang Li, Wei-min Mao, Xiang-hui Wang, Chuan-ding Yu, Ling-bin Du
OBJECTIVE: To investigate the incidence and mortality of cancer registered in Zhejiang province in 2009. METHODS: The statistics of incidence and mortality of cancer were collected from 6 population-based cancer registries in Zhejiang province, including 30 613 new incidence cases and 16 920 death cases reported in 2009. The 6 cancer registries covered population at 9 560 699 in all. The crude rate, age-standardized rate, cumulative rate (0-74 years old), cut rate (35-64 years old), age-specific rate of incidence/mortality as well as the constitution of top 10 common cancers were then calculated and analyzed...
July 2013: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/24278149/association-between-microrna-polymorphisms-and-cancer-risk-based-on-the-findings-of-66-case-control-studies
#16
Xiao Pin Ma, Ting Zhang, Bo Peng, Long Yu, De Ke Jiang
MicroRNAs (miRNAs) are small non-coding RNA molecules, which participate in diverse biological processes and may regulate tumor suppressor genes or oncogenes. Single nucleotide polymorphisms (SNPs) in miRNA may contribute to diverse functional consequences, including cancer development, by altering miRNA expression. Numerous studies have shown the association between miRNA SNPs and cancer risk; however, the results are generally debatable and inconclusive, mainly due to limited statistical power. To assess the relationship between the five most common SNPs (miR-146a rs2910164, miR-196a2 rs11614913, miR-499 rs3746444, miR-149 rs2292832, and miR-27a rs895919) and the risk cancer development, we performed a meta-analysis of 66 published case-control studies...
2013: PloS One
https://www.readbyqxmd.com/read/24186596/transforming-growth-factor-%C3%AE-1-tgf%C3%AE-1-in-physiology-and-pathology
#17
REVIEW
Dariusz Kajdaniuk, Bogdan Marek, Halina Borgiel-Marek, Beata Kos-Kudła
This review describes precisely the consequence of TGFβ1 prevalence in the organism, and its significant influence on physiological and pathophysiological processes. Organ and tissue distinctiveness hinder unambiguous characterisation of the cytokine. However, there are constant functions of TGFβ1 inducing no controversy: it participates in foetal development, control of cell growth and differentiation, induces fibrosis and scar formation (the process of 'wound healing'), causes the suppression of immune response, is involved in angiogenesis, the development of tumours, and inflammatory processes...
2013: Endokrynologia Polska
https://www.readbyqxmd.com/read/23676419/prevalence-and-risk-factors-of-extrapancreatic-malignancies-in-a-large-cohort-of-patients-with-intraductal-papillary-mucinous-neoplasm-ipmn-of-the-pancreas
#18
MULTICENTER STUDY
A Larghi, N Panic, G Capurso, E Leoncini, D Arzani, R Salvia, M Del Chiaro, L Frulloni, P G Arcidiacono, A Zerbi, R Manta, C Fabbri, M Ventrucci, I Tarantino, M Piciucchi, A Carnuccio, U Boggi, G Costamagna, G Delle Fave, R Pezzilli, C Bassi, M Bulajic, W Ricciardi, S Boccia
BACKGROUND: The objectives of this study are to estimate prevalence and incidence of extrapancreatic malignancies (EPMs) among intraductal papillary mucinous neoplasms (IPMNs) of the pancreas, and to identify risk factors for their occurrence. PATIENTS AND METHODS: We conducted multicentric cohort study in Italy from January 2010 to January 2011 including 390 IPMN cases. EPMs were grouped as previous, synchronous (both prevalent) and metachronous (incident). We calculated the observed/expected (O/E) ratio of prevalent EPMs, and compared the distribution of demographic, medical history and lifestyle habits...
July 2013: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/23589795/the-prevalence-and-clinical-characteristics-of-cancer-among-anemia-patients-treated-at-an-outpatient-clinic
#19
Soo Jeong Kim, So Young Ha, Bo Mi Choi, Mi Yeong Lee, Jong Youl Jin, Soo Jeong Yeom, Tae Wan Kim, Young Min Kim, Keehyun Lee
BACKGROUND: Anemia is the most common hematologic condition encountered in outpatient clinics. It is often overlooked because it is common among patients; however, anemia is one of the leading indicators of cancer. This study examined the prevalence and characteristics of cancer among anemia patients who visited an outpatient clinic. METHODS: The data were collected by reviewing the records of an outpatient clinic from January 2007 to December 2011. RESULTS: In total, 502 patients (52 males, 450 females) were diagnosed with anemia...
March 2013: Blood Research
https://www.readbyqxmd.com/read/23497644/role-of-maspin-in-cancer
#20
Rossana Berardi, Francesca Morgese, Azzurra Onofri, Paola Mazzanti, Mirco Pistelli, Zelmira Ballatore, Agnese Savini, Mariagrazia De Lisa, Miriam Caramanti, Silvia Rinaldi, Silvia Pagliaretta, Matteo Santoni, Chiara Pierantoni, Stefano Cascinu
Maspin (mammary serine protease inhibitor), is a member of the serine protease inhibitor/non-inhibitor superfamily. Its expression is down-regulated in breast, prostate, gastric and melanoma cancers but over-expressed in pancreatic, gallbladder, colorectal, and thyroid cancers suggesting that maspin may play different activities in different cell types. However, maspin expression seems to be correlated with better prognosis in prostate, bladder, lung, gastric, colorectal, head and neck, thyroid and melanoma cancer...
2013: Clinical and Translational Medicine
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