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https://www.readbyqxmd.com/read/29136407/phospholipase-d-inhibitors-reduce-human-prostate-cancer-cell-proliferation-and-colony-formation
#1
Amanda R Noble, Norman J Maitland, Daniel M Berney, Martin G Rumsby
BACKGROUND: Phospholipases D1 and D2 (PLD1/2) hydrolyse cell membrane glycerophospholipids to generate phosphatidic acid, a signalling lipid, which regulates cell growth and cancer progression through effects on mTOR and PKB/Akt. PLD expression and/or activity is raised in breast, colorectal, gastric, kidney and thyroid carcinomas but its role in prostate cancer (PCa), the major cancer of men in the western world, is unclear. METHODS: PLD1 protein expression in cultured PNT2C2, PNT1A, P4E6, LNCaP, PC3, PC3M, VCaP, 22RV1 cell lines and patient-derived PCa cells was analysed by western blotting...
November 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28981482/vital-signs-trends-in-incidence-of-cancers-associated-with-overweight-and-obesity-united-states-2005-2014
#2
C Brooke Steele, Cheryll C Thomas, S Jane Henley, Greta M Massetti, Deborah A Galuska, Tanya Agurs-Collins, Mary Puckett, Lisa C Richardson
BACKGROUND: Overweight and obesity are associated with increased risk of at least 13 different types of cancer. METHODS: Data from the United States Cancer Statistics for 2014 were used to assess incidence rates, and data from 2005 to 2014 were used to assess trends for cancers associated with overweight and obesity (adenocarcinoma of the esophagus; cancers of the breast [in postmenopausal women], colon and rectum, endometrium, gallbladder, gastric cardia, kidney, liver, ovary, pancreas, and thyroid; meningioma; and multiple myeloma) by sex, age, race/ethnicity, state, geographic region, and cancer site...
October 3, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28818111/estimates-of-cancer-incidence-and-mortality-in-china-2013
#3
Rongshou Zheng, Hongmei Zeng, Siwei Zhang, Wanqing Chen
INTRODUCTION: Population-based cancer registration data are collected by the National Central Cancer Registry in China every year. Cancer incident cases and cancer deaths in 2013 were analyzed. METHODS: Through the procedure of quality control, reported data from 255 registries were accepted to establish the national database for cancer estimates. Incidences and mortalities were calculated with stratification by area (urban/rural), sex (male/female), age group (0, 1-4, 5-9, 10-14 … 80-84, and 85-year-old and above), and cancer site...
August 17, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28550623/malignant-tumors-associated-with-juvenile-polyposis-syndrome-in-japan
#4
REVIEW
Hideyuki Ishida, Keiichiro Ishibashi, Takeo Iwama
PURPOSE: The risk of malignant tumors developing in association with juvenile polyposis syndrome (JPS) was evaluated to explore the optimal treatment for this rare disease. METHODS: We reviewed the data on JPS cases reported in Japan between January, 1971 and March, 2016. RESULTS: A total of 171 cases were evaluable. Of these 171 patients, 83 (48.5%) were female and the median age at diagnosis was 28 years (range 1-80 years). The polyps were located in the stomach alone (n = 62; 36...
May 26, 2017: Surgery Today
https://www.readbyqxmd.com/read/28243543/development-and-validation-of-a-36-gene-sequencing-assay-for-hereditary-cancer-risk-assessment
#5
Valentina S Vysotskaia, Gregory J Hogan, Genevieve M Gould, Xin Wang, Alex D Robertson, Kevin R Haas, Mark R Theilmann, Lindsay Spurka, Peter V Grauman, Henry H Lai, Diana Jeon, Genevieve Haliburton, Matt Leggett, Clement S Chu, Kevin Iori, Jared R Maguire, Kaylene Ready, Eric A Evans, Hyunseok P Kang, Imran S Haque
The past two decades have brought many important advances in our understanding of the hereditary susceptibility to cancer. Numerous studies have provided convincing evidence that identification of germline mutations associated with hereditary cancer syndromes can lead to reductions in morbidity and mortality through targeted risk management options. Additionally, advances in gene sequencing technology now permit the development of multigene hereditary cancer testing panels. Here, we describe the 2016 revision of the Counsyl Inherited Cancer Screen for detecting single-nucleotide variants (SNVs), short insertions and deletions (indels), and copy number variants (CNVs) in 36 genes associated with an elevated risk for breast, ovarian, colorectal, gastric, endometrial, pancreatic, thyroid, prostate, melanoma, and neuroendocrine cancers...
2017: PeerJ
https://www.readbyqxmd.com/read/28132182/applications-of-metabolomics-in-cancer-studies
#6
REVIEW
Emily Grace Armitage, Michal Ciborowski
Since the start of metabolomics as a field of research, the number of studies related to cancer has grown to such an extent that cancer metabolomics now represents its own discipline. In this chapter, the applications of metabolomics in cancer studies are explored. Different approaches and analytical platforms can be employed for the analysis of samples depending on the goal of the study and the aspects of the cancer metabolome being investigated. Analyses have concerned a range of cancers including lung, colorectal, bladder, breast, gastric, oesophageal and thyroid, amongst others...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28106227/can-ngal-be-employed-as-prognostic-and-diagnostic-biomarker-in-human-cancers-a-systematic-review-of-current-evidence
#7
REVIEW
Laura Roli, Valentina Pecoraro, Tommaso Trenti
BACKGROUND: Some studies have reported differentially altered neutrophil gelatinase-associated lipocalin (NGAL) levels in several malignancies. We evaluated NGAL measured in plasma or urine as both prognostic and diagnostic marker for different types of human tumors. METHODS: We performed systematic electronic searches in Medline, Embase and CRDTAS. Studies were included if they evaluated NGAL as a prognostic or diagnostic marker for human cancers. The selection of the studies, screening of the full texts and data extraction were conducted independently by 2 authors...
March 2, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/27685924/high-incidence-of-thyroid-cancer-among-patients-with-acromegaly
#8
Dimitrios Kaldrymidis, Georgios Papadakis, Georgios Tsakonas, Philippos Kaldrymidis, Theofanis Flaskas, Andreas Seretis, Eleni Pantazi, Ifigenia Kostoglou-Athanassiou, Melpomeni Peppa, Paraskevi Roussou, Evanthia Diamanti-Kandarakis
PURPOSE: Several studies have suggested that patients with acromegaly have an increased risk of thyroid, colorectal, breast and prostate cancers. In this study we determined the prevalence of malignant neoplasms in patients with acromegaly. METHODS: Cancer risk was evaluated in a cohort of 110 patients (M/F 48/62, age 58.63±13.8 years, range 30-86) with acromegaly. Mean age at diagnosis of acromegaly was 46.37±13.11 years. Mean period of time since diagnosis of acromegaly was 12...
July 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27486968/association-between-dietary-nitrate-and-nitrite-intake-and-sitespecific-cancer-risk-evidence-from-observational-studies
#9
Li Xie, Miao Mo, Hui-Xun Jia, Fei Liang, Jing Yuan, Ji Zhu
Epidemiological studies have reported inconsistent findings on the association between dietary nitrate and nitrite intake and cancer risk. We performed a meta-analysis of epidemiological studies to summarize available evidence on the association between dietary nitrate and nitrite intake and cancer risk from published prospective and case-control studies. PubMed database was searched to identify eligible publications through April 30th, 2016. Study-specific relative risks (RRs) with corresponding 95% confidence interval (CI) from individual studies were pooled by using random- or fixed- model, and heterogeneity and publication bias analyses were conducted...
August 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27484217/the-incidence-and-mortality-of-major-cancers-in-china-2012
#10
Wanqing Chen, Rongshou Zheng, Hongmei Zeng, Siwei Zhang
BACKGROUND: The National Central Cancer Registry (NCCR) collected population-based cancer registration data in 2012 from local registries and estimated the cancer incidence and mortality in China. METHODS: In the middle of 2015, 261 cancer registries submitted reports on new cancer cases and deaths occurred in 2012. Qualified data from 193 registries were used for analysis after evaluation. Crude rates, number of cases, and age-standardized rates stratified by area (urban/rural), sex, age group, and cancer type were calculated according to the national population in 2012...
August 2, 2016: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/27446351/role-of-periostin-in-esophageal-gastric-and-colon-cancer
#11
Tadeusz Moniuszko, Andrzej Wincewicz, Mariusz Koda, Izabela Domysławska, Stanisław Sulkowski
Periostin, also known as osteoblast-specific factor 2, is a cell-adhesion protein with pleiotropic properties. The protein serves a vital role in the maintenance and development of tooth and bone tissue, in addition to cardiac development and healing. Periostin levels are increased in several forms of cancer, including pancreatic, ovarian, colon, lung, breast, gastric, thyroid, and esophageal head and neck carcinomas. The present review highlights the key role of periostin in tumorigenesis, particularly in increasing cell survival, invasion, angiogenesis, epithelial-mesenchymal transition and metastasis of carcinoma cells by interacting with numerous cell-surface receptors, including integrins, in the phosphoinositide 3-kinase-Akt pathway...
August 2016: Oncology Letters
https://www.readbyqxmd.com/read/26622742/piwil2-modulates-the-invasion-and-metastasis-of-prostate-cancer-by-regulating-the-expression-of-matrix-metalloproteinase-9-and-epithelial-mesenchymal-transitions
#12
Yanfeng Yang, Xuepei Zhang, Dongkui Song, Jinxing Wei
Piwi-like RNA-mediated gene silencing 2 (Piwil2) is an oncogene that is highly expressed in breast, gastric, colorectal and papillary thyroid cancer. As a candidate oncogene, its role in prostrate cancer has yet to be elucidated. In the present study, 30 tumor specimens and four prostate cancer cell lines were analyzed. The total RNA and protein from the specimens and the cells were analyzed using quantitative polymerase chain reaction and western blotting, respectively. The expression of Piwil2 in PC-3 cells was knocked down using specific small hairpin RNA...
September 2015: Oncology Letters
https://www.readbyqxmd.com/read/26414866/differential-protein-expression-and-oncogenic-gene-network-link-tyrosine-kinase-ephrin-b4-receptor-to-aggressive-gastric-and-gastroesophageal-junction-cancers
#13
Britta Liersch-Löhn, Nadia Slavova, Heinz J Buhr, Idriss M Bennani-Baiti
Transmembrane tyrosine-kinase Ephrin receptors promote tumor progression and/or metastasis of several malignancies including leukemia, follicular lymphoma, glioma, malignant pleural mesothelioma, papillary thyroid carcinoma, sarcomas and ovarian, breast, bladder and non-small cell lung cancers. They also drive intestinal stem cell proliferation and positioning, control intestinal tissue boundaries and are involved in liver, pancreatic and colorectal cancers, indicating involvement in additional digestive system malignancies...
March 1, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/26349957/papillary-thyroid-carcinoma-ptc-in-lynch-syndrome-report-of-two-cases-and-discussion-on-lynch-syndrome-behaviour-and-genetics
#14
M R Pelizzo, G Pennelli, M Zane, F Galuppini, P M Colletti, I Merante Boschin, D Rubello
We present here two cases of papillary thyroid carcinoma (PTC) in patients affected by Lynch syndrome (LS). The first case is a 47-year-old woman with typical hereditary non-polyposis colorectal cancer (HNPCC) syndrome, reported with endometrial and ovarian carcinoma at age 43, and colon cancer at age 45. The patient underwent total thyroidectomy and central node dissection in 2007, at 47years old, with a histological diagnosis of PTC (T1aN1a). Molecular genetics showed a germ-line mutation of the MLH1 gene, 1858 G>T(E620X), with substitution of glycine with a stop codon at position 620...
August 2015: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/26048190/annexin-a4-and-cancer
#15
REVIEW
Bin Wei, Chunmei Guo, Shuqing Liu, Ming-Zhong Sun
Annexin A4 (Anxa4) is one of the Ca(2+)-regulated and phospholipid-binding annexin superfamily proteins. Anxa4 has a potential role in diagnosis, prognosis, and treatment of certain cancers. Studies indicate that Anxa4 up-regulation promotes the progression of tumor and chemoresistance of colorectal cancer (CRC), esophageal squamous cell carcinoma (ESCC), endometrial carcinoma (EC), gastric cancer (GC), chemoresistant lung cancer (LC), malignant mesothelioma (MM), renal cell carcinoma (RCC), ovarian clear cell carcinoma (OCCC), cholangiocarcinoma, hepatocellular carcinoma (HCC), breast cancer (BC), and laryngeal cancer...
July 20, 2015: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/26038827/correlation-between-the-uptake-of-18f-fluorodeoxyglucose-18f-fdg-and-the-expression-of-proliferation-associated-antigen-ki-67-in-cancer-patients-a-meta-analysis
#16
Sheng-Ming Deng, Wei Zhang, Bin Zhang, Yin-Yin Chen, Ji-Hui Li, Yi-Wei Wu
OBJECTIVE: To study the correlation between 18F-FDG uptake and cell proliferation in cancer patients by meta-analysis of published articles. METHODS: We searched PubMed (MEDLINE included), EMBASE, and Cochrane Database of Systematic Review, and selected research articles on the relationship between 18F-FDG uptake and Ki-67 expression (published between August 1, 1994-August 1, 2014), according to the literature inclusion and exclusion criteria. The publishing language was limited to English...
2015: PloS One
https://www.readbyqxmd.com/read/25946974/nicotinamide-phosphorybosiltransferase-overexpression-in-thyroid-malignancies-and-its-correlation-with-tumor-stage-and-with-survivin-survivin-dex3-expression
#17
COMPARATIVE STUDY
Nadia Sawicka-Gutaj, Joanna Waligórska-Stachura, Mirosław Andrusiewicz, Maciej Biczysko, Jerzy Sowiński, Jerzy Skrobisz, Marek Ruchała
Nicotinamide phosphorybosiltransferase (NAMPT) plays an important role in the regulation of cellular growth, angiogenesis, and apoptosis in mammalian cells. NAMPT overexpression has been recently found in colorectal, breast, prostatic, gastric, esophageal, pancreatic cancers, and specific NAMPT inhibitors might be adjuvant therapeutic modalities. In this study, we analyzed NAMPT expression in 40 malignant and in 67 benign thyroid tissue samples using qPCR. We also investigated relationships between NAMPT expression and survivin/survivin splicing variants DEx3 and 2B expressions...
September 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/25169130/copy-number-alterations-of-chromosomal-regions-enclosing-protein-tyrosine-phosphatase-receptor-like-genes-in-colorectal-cancer
#18
Izabela Laczmanska, Pawel Karpinski, Joanna Kozlowska, Marek Bebenek, David Ramsey, Tomasz Sedziak, Piotr Ziolkowski, Maria M Sasiadek
Protein tyrosine phosphatases that act in different cellular pathways are described most commonly as tumor suppressors, but also as oncogenes. Their role has previously been described in colorectal cancer, as well as in gastric, breast, thyroid, prostate, ovarian, pancreatic, glioma, liver, leukemia and many other cancers. In a previous study, we have described protein tyrosine phosphatase receptor type T, M, Z1 and Q genes (PTPRT, PTPRM, PTPRZ1 and PTPRQ) hypermethylated in sporadic colorectal cancer. Thus, in this study, we examined the relation of unbalanced chromosomal alterations within regions covering these four protein tyrosine phosphatase genes with this cancer...
December 2014: Pathology, Research and Practice
https://www.readbyqxmd.com/read/25091112/significantly-increased-monounsaturated-lipids-relative-to-polyunsaturated-lipids-in-six-types-of-cancer-microenvironment-are-observed-by-mass-spectrometry-imaging
#19
Shuai Guo, Yanmin Wang, Dan Zhou, Zhili Li
Six different types of cancer (i.e., breast, lung, colorectal, esophageal, gastric, and thyroid cancer) have high rates of incidence or mortality worldwide. It has been shown that activation of de novo lipogenesis is an early and common event in the cancer microenvironment. In this study, we performed lipid imaging and profiling for 134 tissue samples from six different types of cancer using matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry, with 2,5-dihydroxybenzoic acid and 1,8-bis(dimethyl-amino)naphthalene as matrices in the positive and negative ion modes, respectively...
2014: Scientific Reports
https://www.readbyqxmd.com/read/24915871/history-of-chronic-comorbidity-and-risk-of-chemotherapy-induced-febrile-neutropenia-in-cancer-patients-not-receiving-g-csf-prophylaxis
#20
C Chao, J H Page, S-J Yang, R Rodriguez, J Huynh, V M Chia
BACKGROUND: Chemotherapy-induced febrile neutropenia (FN) is a clinically important complication that affects patient outcome by delaying chemotherapy doses or reducing dose intensity. Risk of FN depends on chemotherapy- and patient-level factors. We sought to determine the effects of chronic comorbidities on risk of FN. DESIGN: We conducted a cohort study to examine the association between a variety of chronic comorbidities and risk of FN in patients diagnosed with six types of cancer (non-Hodgkin lymphoma and breast, colorectal, lung, ovary, and gastric cancer) from 2000 to 2009 who were treated with chemotherapy at Kaiser Permanente Southern California, a large managed care organization...
September 2014: Annals of Oncology: Official Journal of the European Society for Medical Oncology
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