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https://www.readbyqxmd.com/read/29145421/radiographic-prediction-of-meningioma-grade-by-semantic-and-radiomic-features
#1
Thibaud P Coroller, Wenya Linda Bi, Elizabeth Huynh, Malak Abedalthagafi, Ayal A Aizer, Noah F Greenwald, Chintan Parmar, Vivek Narayan, Winona W Wu, Samuel Miranda de Moura, Saksham Gupta, Rameen Beroukhim, Patrick Y Wen, Ossama Al-Mefty, Ian F Dunn, Sandro Santagata, Brian M Alexander, Raymond Y Huang, Hugo J W L Aerts
OBJECTIVES: The clinical management of meningioma is guided by tumor grade and biological behavior. Currently, the assessment of tumor grade follows surgical resection and histopathologic review. Reliable techniques for pre-operative determination of tumor grade may enhance clinical decision-making. METHODS: A total of 175 meningioma patients (103 low-grade and 72 high-grade) with pre-operative contrast-enhanced T1-MRI were included. Fifteen radiomic (quantitative) and 10 semantic (qualitative) features were applied to quantify the imaging phenotype...
2017: PloS One
https://www.readbyqxmd.com/read/28967316/combined-petrosal-approach-for-petroclival-meningioma
#2
Omar Arnaout, Ossama Al-Mefty
The authors present the case of a 56-year-old patient who presented with a large petroclival meningioma and clinical symptoms of brainstem compression and hydrocephalus. The authors describe a two-stage combined petrosal approach for complete resection of the tumor. The nuances of the approach and microsurgical technique are discussed, as well as the radiographic and clinical outcomes. The video can be found here: https://youtu.be/JxoTXS-uiHM .
October 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28927207/surgical-approaches-to-the-temporal-horn-an-anatomic-analysis-of-white-matter-tract-interruption
#3
Paulo A S Kadri, Jean G de Oliveira, Niklaus Krayenbühl, Ugur Türe, Evandro P L de Oliveira, Ossama Al-Mefty, Guilherme C Ribas
BACKGROUND: Surgical access to the temporal horn is necessary to treat tumors and vascular lesions, but is used mainly in patients with mediobasal temporal epilepsy. The surgical approaches to this cavity fall into 3 primary categories: lateral, inferior, and transsylvian. The current neurosurgical literature has underestimated the interruption of involved fiber bundles and the correlated clinical manifestations. OBJECTIVE: To delineate the interruption of fiber bundles during the different approaches to the temporal horn...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28791543/chordoma
#4
EDITORIAL
Ossama Al-Mefty
No abstract text is available yet for this article.
October 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28713588/genomic-landscape-of-high-grade-meningiomas
#5
Wenya Linda Bi, Noah F Greenwald, Malak Abedalthagafi, Jeremiah Wala, Will J Gibson, Pankaj K Agarwalla, Peleg Horowitz, Steven E Schumacher, Ekaterina Esaulova, Yu Mei, Aaron Chevalier, Matthew Ducar, Aaron R Thorner, Paul van Hummelen, Anat Stemmer-Rachamimov, Maksym Artyomov, Ossama Al-Mefty, Gavin P Dunn, Sandro Santagata, Ian F Dunn, Rameen Beroukhim
High-grade meningiomas frequently recur and are associated with high rates of morbidity and mortality. To determine the factors that promote the development and evolution of these tumors, we analyzed the genomes of 134 high-grade meningiomas and compared this information with data from 587 previously published meningiomas. High-grade meningiomas had a higher mutation burden than low-grade meningiomas but did not harbor any statistically significant mutated genes aside from NF2. High-grade meningiomas also possessed significantly elevated rates of chromosomal gains and losses, especially among tumors with monosomy 22...
2017: NPJ Genomic Medicine
https://www.readbyqxmd.com/read/28521059/pediatric-clival-chordoma-a-curable-disease-that-conforms-to-collins-law
#6
Marcio S Rassi, M Maher Hulou, Kaith Almefty, Wenya Linda Bi, Svetlana Pravdenkova, Ian F Dunn, Timothy R Smith, Ossama Al-Mefty
BACKGROUND: Skull base chordomas in children are extremely rare. Their course, management, and outcome have not been defined. OBJECTIVE: To describe the preeminent clinical and radiological features in a series of pediatric patients with skull base chordomas and analyze the outcome of a cohort who underwent uniform treatment. We emphasize predictors of overall survival and progression-free survival, which aligns with Collins' law for embryonal tumors. METHODS: Thirty-one patients with a mean age of 10...
May 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28300709/delayed-carotid-pseudoaneurysms-from-iatrogenic-clival-meningeal-branches-avulsion-recognition-and-proposed-management
#7
Rami Almefty, Ian F Dunn, Muhammad Ali Aziz-Sultan, Ossama Al-Mefty
BACKGROUND: Carotid injury during anterior skull base approaches is promptly recognizable and mandates immediate treatment; likewise, development of pseudoaneurysms after such injuries is anticipated and managed. METHODS: We report here on the delayed development of a pseudoaneurysm as the result of avulsion of clival meningeal arteries that manifests as unalarming intraoperative bleeding. RESULTS AND CONCLUSIONS: The bleeding is brisk and arterial but easily controlled...
August 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28291217/-early-postoperative-results-of-surgical-treatment-of-patients-with-anterior-clinoidal-meningiomas
#8
S V Chernov, D A Rzaev, A V Kalinovsky, A B Dmitriev, A R Kasymov, A V Zotov, E V Gormolysova, E K Uzhakova
Resection of anterior clinoidal meningiomas is a challenging task due to their localization, frequent involvement of the major cerebral arteries and cranial nerves, a high risk of postoperative neurological deficits, and low radicalness of surgery. AIM: To evaluate the radicalness of microsurgical removal and a neurological deficit in the early postoperative period in patients with anterior clinoidal meningiomas. MATERIAL AND METHODS: A total of 35 patients with anterior clinoidal meningiomas underwent surgery at the Department of Neurooncology of the Novosibirsk Federal Neurosurgical Center in the period from 2013 to July 2016...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/28259671/hybrid-surgery-management-of-giant-hypervascular-tumors-intraoperative-endovascular-embolization-with-microsurgical-resection
#9
Rami O Almefty, Nirav J Patel, Alfred P See, Ian F Dunn, Ossama Al-Mefty, Mohammed Ali Aziz-Sultan
BACKGROUND: Giant hypervascular intracranial tumors represent a formidable challenge because their size limits surgical control of the blood supply and debulking poses the risk of critical blood loss. Embolization facilitates resection but carries the risk of life-threatening tumor infarction, hemorrhage, or swelling if performed preoperatively. Endovascular intraoperative embolization avoids the fatal risk and allows the surgeon to attend instantly if any complication occurs. METHODS AND RESULTS: We report 2 cases in which combining intraoperative embolization with microsurgical resection in the hybrid operating room was used to safely and successfully remove giant hypervascular tumors...
June 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28175422/130%C3%A2-skull-base-chordomas-in-children-and-young-adults
#10
M Maher Hulou, Marcio S Rassi, Kaith Almefty, Wenya Linda Bi, Ian F Dunn, Timothy R Smith, Ossama Al-Mefty
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28170043/germline-and-somatic-bap1-mutations-in-high-grade-rhabdoid-meningiomas
#11
Ganesh M Shankar, Malak Abedalthagafi, Rachael A Vaubel, Parker H Merrill, Naema Nayyar, Corey M Gill, Ryan Brewster, Wenya Linda Bi, Pankaj K Agarwalla, Aaron R Thorner, David A Reardon, Ossama Al-Mefty, Patrick Y Wen, Brian M Alexander, Paul van Hummelen, Tracy T Batchelor, Keith L Ligon, Azra H Ligon, Matthew Meyerson, Ian F Dunn, Rameen Beroukhim, David N Louis, Arie Perry, Scott L Carter, Caterina Giannini, William T Curry, Daniel P Cahill, Frederick G Barker, Priscilla K Brastianos, Sandro Santagata
Background: Patients with meningiomas have widely divergent clinical courses. Some entirely recover following surgery alone, while others have relentless tumor recurrences. This clinical conundrum is exemplified by rhabdoid meningiomas, which are designated in the World Health Organization Classification of Tumours as high grade, despite only a subset following an aggressive clinical course. Patient management decisions are further exacerbated by high rates of interobserver variability, biased against missing possibly aggressive tumors...
April 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28048264/su-d-207b-02-early-grade-classification-in-meningioma-patients-combining-radiomics-and-semantics-data
#12
T Coroller, W Bi, M Abedalthagafi, A Aizer, W Wu, N Greenwald, R Beroukhim, O Al-Mefty, S Santagata, I Dunn, B Alexander, R Huang, H Aerts
PURPOSE: The clinical management of meningioma is guided by its grade and biologic behavior. Currently, diagnosis of tumor grade follows surgical resection and histopathologic review. Reliable techniques for pre-operative determination of tumor behavior are needed. We investigated the association between imaging features extracted from preoperative gadolinium-enhanced T1-weighted MRI and meningioma grade. METHODS: We retrospectively examined the pre-operative MRI for 139 patients with de novo WHO grade I (63%) and grade II (37%) meningiomas...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27399409/130%C3%A2-skull-base-chordomas-in-children-and-young-adults
#13
M Maher Hulou, Marcio S Rassi, Kaith Almefty, Wenya Linda Bi, Ian F Dunn, Timothy R Smith, Ossama Al-Mefty
INTRODUCTION: Skull base chordomas are rare tumors, with less than 5% occurring in patients younger than 20 years of age. Current understanding and a consensus management strategy for pediatric chordomas remain lacking. We investigated the clinical and radiological features of chordomas in young patients, with an emphasis on surgical outcomes and predictors of survival following our management protocol of radical surgical resection with adjuvant high-dose radiotherapy. METHODS: Data from 31 patients, age 22 years or younger, referred to the senior author (OAM) from 1993 to 2008 were reviewed...
August 2016: Neurosurgery
https://www.readbyqxmd.com/read/27341050/transtentorial-transcollateral-sulcus-approach-to-the-ventricular-atrium-an-endoscope-assisted-anatomical-study
#14
Yasser Jeelani, Abdulkerim Gokoglu, Tomer Anor, Ossama Al-Mefty, Alan R Cohen
OBJECTIVE Conventional approaches to the atrium of the lateral ventricle may be associated with complications related to direct cortical injury or brain retraction. The authors describe a novel approach to the atrium through a retrosigmoid transtentorial transcollateral sulcus corridor. METHODS Bilateral retrosigmoid craniotomies were performed on 4 formalin-fixed, colored latex-injected human cadaver heads (a total of 8 approaches). Microsurgical dissections were performed under 3× to 24× magnification, and endoscopic visualization was provided by 0° and 30° rigid endoscope lens systems...
April 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27090972/endoscope-assisted-microsurgical-approach-to-the-posterior-and-posterolateral-incisural-space
#15
Roberta Rehder, Marcos Perocco Luiz da Costa, Ossama Al-Mefty, Alan R Cohen
OBJECTIVE: Despite recent technological advances, direct approaches to the posterolateral incisural space remain surgical challenges. The choice of the operative route depends on the exact location and extent of the target lesion as well as individual preferences. The extreme lateral infratentorial supracerebellar approach to treat pathologies located in the ambient cistern and posterior incisural space is a technically feasible route in selected cases. In this cadaveric study, we demonstrate the benefits of endoscope-assisted microsurgical maneuvers using the extreme lateral supracerebellar infratentorial approach...
July 2016: World Neurosurgery
https://www.readbyqxmd.com/read/26871376/letter-to-the-editor-cadaveric-csf-reconstitution-model-for-neuroendoscopic-intraventricular-procedures
#16
LETTER
Emad Aboud, Ossama Al-Mefty
No abstract text is available yet for this article.
April 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/26476700/pre-operative-image-based-segmentation-of-the-cranial-nerves-and-blood-vessels-in-microvascular-decompression-can-we-prevent-unnecessary-explorations
#17
Parviz Dolati, Alexandra Golby, Daniel Eichberg, Mohamad Abolfotoh, Ian F Dunn, Srinivasan Mukundan, Mohamed M Hulou, Ossama Al-Mefty
OBJECTIVES: This study was conducted to validate the accuracy of image-based pre-operative segmentation using the gold standard endoscopic and microscopic findings for localization and pre-operative diagnosis of the offensive vessel. PATIENTS AND METHODS: Fourteen TN and 6 HS cases were randomly selected. All patients had 3T MRI, which included thin-sectioned 3D space T2, 3D Time of Flight and MPRAGE Sequences. Imaging sequences were loaded in BrainLab iPlanNet and fused...
December 2015: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/26323607/a-prognostic-cytogenetic-scoring-system-to-guide-the-adjuvant-management-of-patients-with-atypical-meningioma
#18
Ayal A Aizer, Malak Abedalthagafi, Wenya Linda Bi, Margaret C Horvath, Nils D Arvold, Ossama Al-Mefty, Eudocia Q Lee, Lakshmi Nayak, Mikael L Rinne, Andrew D Norden, David A Reardon, Patrick Y Wen, Keith L Ligon, Azra H Ligon, Rameen Beroukhim, Ian F Dunn, Sandro Santagata, Brian M Alexander
BACKGROUND: The appropriate use of adjuvant therapy in patients with gross totally resected atypical meningioma requires an accurate assessment of recurrence risk. We sought to determine whether cytogenetic/genetic characterization may facilitate better estimation of the probability of recurrence. METHODS: We first analyzed our clinical database, including high-resolution DNA copy number data, to identify 11 common copy number aberrations in a pilot cohort of meningiomas of all grades...
February 2016: Neuro-oncology
https://www.readbyqxmd.com/read/26308667/extent-of-resection-and-overall-survival-for-patients-with-atypical-and-malignant-meningioma
#19
Ayal A Aizer, Wenya Linda Bi, Manjinder S Kandola, Eudocia Q Lee, Lakshmi Nayak, Mikael L Rinne, Andrew D Norden, Rameen Beroukhim, David A Reardon, Patrick Y Wen, Ossama Al-Mefty, Nils D Arvold, Ian F Dunn, Brian M Alexander
BACKGROUND: The prognosis for patients with atypical and malignant meningioma is guarded; whether the extent of resection is associated with survival-based outcomes in this population remains poorly defined. This study investigated the association between gross total resection (GTR) and all-cause mortality in patients with atypical and malignant meningioma. METHODS: The Surveillance, Epidemiology, and End Results program was used to identify 575 and 64 patients betweens the ages of 18 and 70 years who were diagnosed with atypical and malignant meningioma, respectively, between 2004 and 2009...
December 15, 2015: Cancer
https://www.readbyqxmd.com/read/26253325/brachytherapy-in-the-treatment-of-recurrent-aggressive-falcine-meningiomas
#20
Hussam Abou Al-Shaar, Kaith K Almefty, Mohammad Abolfotoh, Nils D Arvold, Phillip M Devlin, David A Reardon, Jay S Loeffler, Ossama Al-Mefty
Recurrent aggressive falcine meningiomas are uncommon tumors that recur despite receiving extensive surgery and radiation therapy (RT). We have utilized brachytherapy as a salvage treatment in two such patients with a unique implantation technique. Both patients had recurrence of WHO Grade II falcine meningiomas despite multiple prior surgical and RT treatments. Radioactive I-125 seeds were made into strands and sutured into a mesh implant, with 1 cm spacing, in a size appropriate to cover the cavity and region of susceptible falcine dura...
September 2015: Journal of Neuro-oncology
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