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https://www.readbyqxmd.com/read/29436101/chemoembolization-related-to-good-survival-for-selected-patients-with-hepatocellular-carcinoma-invading-segmental-portal-vein
#1
Jin Hyoung Kim, Ju Hyun Shim, Hyun-Ki Yoon, Heung-Kyu Ko, Jong Woo Kim, Dong Il Gwon
BACKGROUND AND AIMS: We evaluated survival outcomes and prognostic factors associated with survival after transarterial chemoembolization (TACE) in a large cohort of 331 patients with hepatocellular carcinoma (HCC) with segmental portal vein tumor thrombosis (PVTT). METHODS: From 1997 to 2015, a total of 331 patients were included in this study from among 507 patients who underwent TACE as a first-line treatment for HCC with segmental PVTT. RESULTS: After TACE, the median survival of the whole cohort was 10...
February 13, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29390197/advanced-recurrent-hepatocellular-carcinoma-treatment-with-sorafenib-alone-or-in-combination-with-transarterial-chemoembolization-and-radiofrequency-ablation
#2
Zhenwei Peng, Shuling Chen, Mengchao Wei, Manxia Lin, Chunlin Jiang, Jie Mei, Bin Li, Yu Wang, Jiaping Li, Xiaoyan Xie, Minshan Chen, Guojun Qian, Ming Kuang
Purpose To retrospectively investigate the safety and efficacy of sorafenib combined with transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) (hereafter, TACE-RFA) in the treatment of recurrent hepatocellular carcinoma (rHCC) with portal vein tumor thrombosis, extrahepatic metastases (advanced hepatocellular carcinoma), or both after initial hepatectomy. Materials and Methods The study was centrally approved by the ethics committee of three tertiary medical centers in China. From January 2010 to January 2015, 207 consecutive patients with advanced rHCC after initial hepatectomy received sorafenib combined with TACE-RFA (combination group, n = 106) or sorafenib alone (sorafenib group, n = 101) at the three medical centers...
February 1, 2018: Radiology
https://www.readbyqxmd.com/read/29378532/intra-arterial-ethanol-embolization-augments-response-to-tace-for-treatment-of-hcc-with-portal-venous-tumor-thrombus
#3
Biao Yang, Chun-Lin Li, Wen-Hao Guo, Tian-Qiang Qin, He Jiao, Ze-Jun Fei, Xuan Zhou, Lin-Jia Duan, Zheng-Yin Liao
BACKGROUND: The prognosis of hepatocellular carcinoma with portal vein tumor thrombus remains extremely poor. This pilot study aimed to evaluate the technical feasibility, effectiveness and safety of transcatheter chemoembolization for tumors in the liver parenchyma plus intra-arterial ethanol embolization for portal vein tumor thrombus. METHODS: A pilot study was carried out on 31 patients in the treatment group (transcatheter chemoembolization plus intra-arterial ethanol embolization) and 57 patients in the control group (transcatheter chemoembolization alone)...
January 29, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29317950/a-biliobronchial-fistula-in-a-patient-with-hepatocellcular-carcinoma-treated-with-chemoembolization-diagnosed-by-hepatobiliary-iminodiacetic-acid-scan-and-managed-by-endoscopic-retrograde-cholangiopancreatography
#4
Yousef Nassar, Sven Hida, Seth Richter
A biliobronchial fistula is an abnormal communication between the biliary tract and the bronchial tree. It may be a rare complication after treatment of hepatocellular carcinoma with transcatheter arterial chemoembolization (TACE). We present a case of a 71-year-old man that developed a biliobronchial fistula as a complication of hepatocellular carcinoma treated with TACE. It was successfully diagnosed by hepatobiliary iminodiacetic acid (HIDA) scan and treated with endoscopic retrograde pancreatography.
December 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/29237901/transarterial-chemoembolization-with-gelatin-sponge-microparticles-for-barcelona-clinic-liver-cancer-stage-c-and-large-hepatocellular-carcinoma-initial-clinical-experience
#5
Jun Zhou, Ying Liu, Zhizhong Ren, Yuewei Zhang, Ming Zhang
OBJECTIVE: The purpose of this investigation is to present a preliminary clinical experience in transarterial chemoembolization (TACE) with gelatin sponge microparticles (GSMs) for barcelona clinic liver cancer (BCLC) Stage C and large hepatocellular carcinoma (HCC) patients in China. MATERIALS AND METHODS: Between August 2009 and August 2012, 20 BCLC Stage C HCC patients with tumor size ≥5 cm undergoing GSMs-TACE were retrospectively analyzed. Tumor response was evaluated using modified response evaluation criteria in solid tumors (mRECIST) with enhanced magnetic resonance/computed tomography imaging performed 4-6 weeks after each GSMs-TACE procedure...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29212179/impact-of-cavitron-ultrasonic-surgical-aspirator-cusa-and-bipolar-radiofrequency-device-habib-4x-based-hepatectomy-for-hepatocellular-carcinoma-on-tumour-recurrence-and-disease-free-survival
#6
Kai-Wen Huang, Po-Huang Lee, Tomokazu Kusano, Isabella Reccia, Kumar Jayant, Nagy Habib
Background: The aim of this study was to evaluate the oncological outcomes of hepatocellular carcinoma patients undergoing liver resection using cavitron ultrasonic surgical aspirator (CUSA) or radiofrequency (RF) based device Habib-4X.
. Study Design: We prospectively analyzed the data of 280 patients who underwent liver resection for hepatocellular carcinoma at our institution from 2010-2012 with follow up till August 2016. The CUSA was used in the 163 patients whilst Habib-4X in 117 patients...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29174493/surgical-resection-versus-transarterial-chemoembolization-for-bclc-intermediate-stage-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#7
REVIEW
Lei Liang, Hao Xing, Han Zhang, Jianhong Zhong, Chao Li, Wan Yee Lau, Mengchao Wu, Feng Shen, Tian Yang
BACKGROUND & OBJECTIVE: Transarterial chemoembolization (TACE) is recommended as the first-line therapy for intermediate stage hepatocellular carcinoma (HCC) according to the Barcelona Clinic Liver Cancer (BCLC) algorithm. However, in clinical practice, many such patients undergo surgical resection. A meta-analysis with a systematic search of the medical literature was conducted to compare these two procedures for BCLC intermediate stage HCC. METHODS: PubMed, Embase, Medline and Cochrane library were searched for studies comparing surgical resection with TACE for BCLC intermediate stage HCC that were published before December 2016...
February 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29137099/chemoembolization-for-hepatocellular-carcinoma-fed-by-right-internal-thoracic-artery
#8
Tao Shen, Zhongzhi Jia, Yuanquan Huang, Shaoqin Li, Guomin Jiang, Lihua Cheng
The purpose of the study was to evaluate the value of transarterial chemoembolization (TACE) via right internal thoracic artery (RITA) for patients with unresectable hepatocellular carcinoma (HCC).From January 2000 to June 2016, a retrospective study was conducted of all patients with unresectable HCC who underwent TACE via RITA across 3 medical centers. The technical success, serum alpha-fetoprotein (AFP) level changes, major complications, disease control rate, and survival were evaluated and analyzed.During the study peroid, in all, 21 patients (men 21; mean age 57...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29133753/transcatheter-arterial-chemoembolization-combined-with-simultaneous-computed-tomography-guided-radiofrequency-ablation-for-large-hepatocellular-carcinomas
#9
Tai-Yang Zuo, Feng-Yong Liu, Mao-Qiang Wang, Xian-Xian Chen
BACKGROUND: Currently, the treatment of large hepatocellular carcinoma (HCC) is still a challenging problem. Transcatheter arterial chemoembolization (TACE) is the main treatment for intermediate end-stage HCC, while it is only a palliative and not a curative treatment due to the existence of residual tumors, and radiofrequency ablation (RFA) has limitations in complete ablation of large HCC. We hypothesized that TACE combined with simultaneous RFA (herein referred to as TACE + RFA) could improve the efficacy and survival of large HCC...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29124894/combined-transcatheter-arterial-chemoembolization-and-radiofrequency-ablation-in-single-session-for-solitary-hepatocellular-carcinoma-larger-than-7%C3%A2-cm
#10
Jie-Yu Yan, Jin-Long Zhang, Mao-Qiang Wang, Kai Yuan, Yan-Hua Bai, Yan Wang, Hai-Nan Xin, Zhi-Jun Wang, Feng-Yong Liu, Feng Duan, Jin-Xin Fu
AIMS: To evaluate technical feasibility and treatment results of combined transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) in single-session for solitary hepatocellular carcinoma (HCC) larger than 7 cm in diameter. METHODS: Institutional review board approved this retrospective study. Written informed consent was obtained from all patients. Between June 2007 and July 2013, 87 patients (75 men, 12 women; mean age, 55.5 years ± 15...
November 10, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29116741/high-performance-plga-magnetic-microspheres-prepared-by-rotating-membrane-emulsification-for-transcatheter-arterial-embolization-and-magnetic-ablation-in-vx2-liver-tumors
#11
Yi-Jun Liang, Hui Yu, Guodong Feng, Linlin Zhuang, Wei Xi, Ming Ma, Jun Chen, Ning Gu, Yu Zhang
Interventional embolization is a popular minimally invasive vascular therapeutic technique and has been widely applied for hepatocellular carcinoma (HCC) therapy. However, harmful effects caused by transcatheter arterial chemoembolization (TACE) and radioembolization, such as the toxicity of chemotherapy or excessive radiation damage, are serious disadvantages and significantly reduce the therapeutic efficacy. Here, a synergistic therapeutic strategy combined transcatheter arterial embolization and magnetic ablation (TAEMA) by using PLGA-magnetic microspheres (MMs) has been successfully applied to orthotopic VX2 liver tumors of rabbits...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29097347/dual-balloon-infusion-microcatheter-for-selective-drug-eluting-bead-transarterial-chemoembolization-initial-feasibility-study
#12
Wayne L Monsky, Siddharth A Padia, Andrew Hal Hardy
PURPOSE: We aimed to demonstrate feasibility of the use of a dual-balloon infusion microcatheter for segmental/subsegmental drug-eluting bead transarterial chemoembolization (DEB-TACE). METHODS: Over a 16-month period, 15 segmental and 21 subsegmental DEB-TACE procedures were attempted using a dual-balloon anti-reflux microcatheter (IsoFlow™ microcatheter, Vascular Designs Inc.) in 21 patients (15 males; median age, 61 years; range, 49-82 years) with hepatocellular carcinoma (Barcelona clinic liver cancer stage A [n=4]; B [n=12]; C [n=5]) with one to three tumors, median size of 3...
November 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29082223/healthcare-costs-of-transarterial-chemoembolization-in-the-treatment-of-hepatocellular-carcinoma
#13
Waleed Fateen, Farooq Khan, Richard J O'Neill, Martin W James, Stephen D Ryder, Guruprasad P Aithal
BACKGROUND: A meta-analysis comparing drug-eluting beads transarterial chemoembolization (DEB-TACE) with conventional transarterial chemoembolization (cTACE) has recently been published. On balance, no significant differences were found in terms of objective response and overall survival. The impact on healthcare costs had been studied in small series based on a hypothetical model and was in favor of DEB-TACE. We aimed to evaluate and compare health-care costs and effectiveness of both modalities in a cohort of patients from Nottingham, UK...
2017: Journal of Hepatocellular Carcinoma
https://www.readbyqxmd.com/read/29067511/safety-and-efficacy-of-transarterial-radioembolization-combined-with-chemoembolization-for-bilobar-hepatocellular-carcinoma-a-single-center-retrospective-study
#14
Joon Ho Kwon, Gyoung Min Kim, Kichang Han, Jong Yun Won, Man Deuk Kim, Do Yun Lee, Junhyung Lee, Woosun Choi, Yong Seek Kim, Do Young Kim, Kwang-Hyub Han
BACKGROUND: Radioembolization induced liver disease (REILD) is a possible sequela of transarterial radioembolization (TARE), particularly in cases of whole-liver treatment. To mitigate this problem, the safety and efficacy of combined transarterial chemoembolization (TACE) and TARE were evaluated for patients with bilobar hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Nineteen patients (mean age 60 years; range 27-82 years) treated for HCC between June 2012 and September 2014 were included in the analysis...
October 24, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29063856/does-neoadjuvant-doxorubicin-drug-eluting-bead-transarterial-chemoembolization-improve-survival-in-patients-undergoing-liver-transplant-for-hepatocellular-carcinoma
#15
Dimitri Dorcaratto, Venkatesha Udupa, Niamh M Hogan, David P Brophy, Jeffrey W McCann, Donal Maguire, Justin Geoghegan, Colin P Cantwell, Emir Hoti
PURPOSE: We aimed to compare the overall (OS) and disease-free survival (DFS) of patients undergoing orthotopic liver transplant (OLT) for hepatocellular carcinoma who did and did not have neoadjuvant doxorubicin drug-eluting bead transarterial chemoembolization (DEB-TACE). METHODS: This is a retrospective study of 94 patients with HCC transplanted between 2000 and 2014 in a single tertiary center. Pre- and postoperative features, DFS and OS were compared between patients who received pre-OLT DEB-TACE (n=34, DEB-TACE group) and those who did not (n=60, non-TACE group)...
November 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29063780/transarterial-chemoembolization-with-dc-bead-lumi%C3%A2-radiopaque-beads-for-primary-liver-cancer-treatment-preliminary-experience
#16
Camillo Aliberti, Riccardo Carandina, Donatella Sarti, Enrico Pizzirani, Gaetano Ramondo, Umberto Cillo, Stefano Guadagni, Giammaria Fiorentini
AIM: Primary objectives of the study were to assess the safety of transarterial chemoembolization (TACE) using DC Bead LUMI™ for the treatment of hepatocellular carcinoma and beads distribution after TACE. PATIENTS/METHODS: This was a prospective observational cohort study. The study included 44 hepatocellular carcinoma patients who were treated with TACE using DC Bead LUMI. Beads distribution was monitored 1 h after TACE by CT scan. RESULTS: TACE had no intraprocedural complications...
October 24, 2017: Future Oncology
https://www.readbyqxmd.com/read/29050954/the-trendy-multi-center-randomized-trial-on-hepatocellular-carcinoma-trial-qa-including-automated-treatment-planning-and-benchmark-case-results
#17
Steven J M Habraken, Abdul Wahab M Sharfo, Jeroen Buijsen, Wilko F A R Verbakel, Cornelis J A Haasbeek, Michel C Öllers, Henrike Westerveld, Niek van Wieringen, Onne Reerink, Enrica Seravalli, Pètra M Braam, Markus Wendling, Thomas Lacornerie, Xavier Mirabel, Reinhilde Weytjens, Lieselotte Depuydt, Stephanie Tanadini-Lang, Oliver Riesterer, Karin Haustermans, Tom Depuydt, Roy S Dwarkasing, François E J A Willemssen, Ben J M Heijmen, Alejandra Méndez Romero
BACKGROUND AND PURPOSE: The TRENDY trial is an international multi-center phase-II study, randomizing hepatocellular carcinoma (HCC) patients between transarterial chemoembolization (TACE) and stereotactic body radiation therapy (SBRT) with a target dose of 48-54 Gy in six fractions. The radiotherapy quality assurance (QA) program, including prospective plan feedback based on automated treatment planning, is described and results are reported. MATERIALS AND METHODS: Scans of a single patient were used as a benchmark case...
October 16, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29042529/value-of-preoperative-indocyanine-green-clearance-test-for-predicting-post-hepatectomy-liver-failure-in-noncirrhotic-patients
#18
Cem Ibis, Dogan Albayrak, Tayfun Sahiner, Yigit Soytas, Basak Gurtekin, Nukhet Sivrikoz
BACKGROUND Liver failure is the most feared complication following hepatectomy. Post-hepatectomy liver failure (PHLF) is closely related to the remnant liver volume, and functional reserve. There are several methods for predicting PHLF prior to liver resection. The indocyanine green (ICG) clearance test was popularized in patients with hepatocellular cancer (HCC). We aim to demonstrate the value of preoperative ICG clearance measurement via pulse spectrophotometer (LIMON®) in prediction of PHLF in noncirrhotic patients prior to liver resection...
October 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28937273/cone-beam-ct-acquisition-during-transradial-tace-made-easy-use-of-the-swivel-arm-board
#19
Uei Pua, Chia Chia Teo, Pe Thet U, Lawrence Han Hwee Quek
OBJECTIVE: Transradial access for peripheral intervention often requires certain modification from its coronary counterparts. One of the challenges during transradial transarterial chemoembolization (TACE) is the need for the access arm to be repositioned during cone-beam CT (CBCT) acquisition to allow for C-arm rotation. We recently introduced a swivel arm board to allow seamless repositioning of the access arm during and after CBCT acquisition. The purpose of this study is to detail the technique and feasibility of this useful adjunct to transradial TACE...
October 26, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28931768/study-of-hepatic-artery-cone-beam-imaging-by-low-rate-injection-in-iodinated-contrast-agent
#20
Mitsuru Osawa, Tadafumi Takano, Akihiko Hanawa, Yasuhiro Minami, Hiroshi Miura
PURPOSE: CT during hepatic arteriography (CTHA) of cone-beam computed tomography (CBCT) provides valid information in performing transcatheter arterial chemo-embolization (TACE). The usefulness of CTHA with the diluted contrast medium has been reported in some medical conferences. However, the operation becomes somehow complicated for the medical institutions that have angiography injectors with a single head. In this study, we aimed to investigate the clinical equivalence of low-rate injection method and diluted injection method...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
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