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TACE complications

Ran Tao, Xiaodan Li, Ruizhi Ran, Zhihua Xiao, Hongyue Zhang, Hongyan Kong, Qiqin Song, Yu Huang, Likui Wang, Jiaquan Huang
Hepatocellular carcinoma (HCC) is usually managed by the transcatheter arterial chemoembolization (TACE). However, this technique has been challenged since severe complications have been observed in clinical practices. As a result, clinicians have started to seek other minimally invasive surgeries with equivalent efficacy. The corresponding surgeries were assessed by the five outcomes: complete response (CR), partial response (PR), stable disease (SD), progression disease (PD) and objective response rate (ORR)...
September 29, 2016: Oncotarget
Pu Zhao Wu, Jun Zhou, Yue Wei Zhang
Spontaneous rupture of hepatocellular carcinoma hemorrhage is life-threatening. The aim of the present study was to retrospectively analyze the effect of gelatin sponge microparticles (GSMs) of various diameters on the treatment of spontaneous rupture of hepatocellular carcinoma hemorrhage. GSMs serve as embolization agents by transcatheter arterial chemoembolization (TACE), and the current study analyzed their safety and efficacy. Data from a total of 13 cases of spontaneous rupture of hepatocellular carcinoma hemorrhage, who were treated with GSM-TACE at the Affiliated Zhongshan Hospital of Dalian University (Dalian, China) between August 2010 and June 2014, were collected...
October 2016: Experimental and Therapeutic Medicine
Jian-Ping Dou, Jie Yu, Zhi-Yu Han, Fang-Yi Liu, Zhi-Gang Cheng, Ping Liang
PURPOSE: To evaluate the feasibility, efficacy, and safety of microwave ablation (MWA) in the treatment of hepatocellular carcinoma associated with Budd-Chiari syndrome (BCS) after transarterial chemoembolization (TACE). METHODS: A total of 10 patients (mean 50.0 ± 7.5 years) with 15 BCS-associated HCC lesions were retrospectively evaluated. All patients received MWA treatment for residual tumors after 1 to 3 sessions of TACE. The diagnosis of residual tumors was confirmed by at least two types of enhanced imaging...
September 29, 2016: Abdominal Radiology
Aiman Obed, Abdalla Bashir, Anwar Jarrad
BACKGROUND Hepatitis C virus (HCV) genotype 4 (GT-4) is widespread in the Middle East, where it is responsible for the majority of HCV infections. It shows moderate treatment response rates when compared to other genotypes in the current era of interferon-based regimens. However, in the era of direct acting antiviral (DAA) drugs, its response is at least as good as observed for HCV genotypes 1-3. CASE REPORT We present a case of a 44-year-old patient with HCV cirrhosis. Since 2007, he has been treated for HCV infection with multiple ineffective regimens of interferon (INF) and ribavirin...
September 20, 2016: American Journal of Case Reports
Chen Xiaohong, Lv WenLv, Liu ZhongHua, Shen Bo, Cao XueSen, Nie YuXin, Yu JiaWei, Xu JiaRui, Ding XiaoQiang, Zou JianZhou
Transcatheter arterial chemoembolization (TACE) is an effective therapy for hepatocellular carcinoma (HCC). However, acute kidney injury (AKI) may occur after TACE due to the contrast agent and cytotoxic anticancer drugs used in this procedure. Post-TACE AKI is not an unusual event, and may adversely affect patient outcome. Coexisting situations including cirrhosis, renal insufficiency, diabetes and hypertension play a role in the development of HCC, and may predispose patients to AKI after TACE. Most post-TACE are transient and reversible, while prolonged AKI may predict a decreased survival...
September 9, 2016: Current Protein & Peptide Science
Laila Lobo, Danny Yakoub, Omar Picado, Caroline Ripat, Fiorella Pendola, Rishika Sharma, Rana ElTawil, Deukwoo Kwon, Shree Venkat, Loraine Portelance, Raphael Yechieli
BACKGROUND: Transarterial radioembolization (TARE) has emerged as a newer regional therapy to transarterial chemoembolization (TACE) for treatment of unresectable hepatocellular carcinoma (HCC). The aim of this study is to compare clinical outcomes of both the techniques. METHODS: Online search for studies comparing TARE to TACE from 2005 to present was performed. Primary outcome was overall survival rate for up to 4 years. Secondary outcomes included post-treatment complications and treatment response...
November 2016: Cardiovascular and Interventional Radiology
Kyoung Doo Song, Min Woo Lee, Hyunchul Rhim, Young-Sun Kim, Tae Wook Kang, Sung Wook Shin, Sung Ki Cho
OBJECTIVE: The goal of this study is to evaluate the outcomes of combined transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) in terms of the frequency of aggressive intrasegmental recurrence. MATERIALS AND METHODS: Sixty-one patients (43 men and 18 women; mean [± SD] age, 65.8 ± 8.6 years; age range, 44-82 years) with 71 HCCs (mean [± SD] size, 2.8 ± 0.9 cm; range, 0.7-4.2 cm) underwent combined TACE and RFA...
August 30, 2016: AJR. American Journal of Roentgenology
Massimo Venturini, Claudio Sallemi, Giulia Agostini, Paolo Marra, Stefano Cereda, Michele Reni, Luca Aldrighetti, Francesco De Cobelli, Alessandro Del Maschio
OBJECTIVES: Aim of our preliminary study was to compare the efficacy of DEBIRI vs. DEBDOX as second line treatment of unresectable liver metastases from cholangiocarcinoma. METHODS: In 2013, 10 patients affected by multiple liver metastases from cholangiocarcinoma, resistant to the first line chemotherapy regimen, were enrolled: 5 were submitted to lobar/segmental TACE with DEBIRI (100mg Irinotecan/1vial) and 5 with DEBDOX (50mg Doxorubicin/1vial), performed every 3 weeks...
August 25, 2016: British Journal of Radiology
Cheng Wu Tang, Ming Zhu, Wen Ming Feng, Ying Bao, Yin Yuan Zheng
OBJECTIVE: This study aimed to investigate the efficacy of Jianpi Ligan decoction (JLD) as an adjuvant therapy for patients with unresectable hepatocellular carcinoma (HCC) treated by transarterial chemoembolization (TACE). METHODS: From March 2007 to March 2013, 103 patients with unresectable HCC who underwent TACE in our center were included in this retrospective study. Among the 103 patients, 53 patients accepted JLD along with TACE (JLD group) and 50 patients accepted TACE alone (control group)...
2016: Drug Design, Development and Therapy
Aijun Li, Senlin Ma, Timothy Pawlik, Bin Wu, Xiaoyu Yang, Longjiu Cui, Mengchao Wu
Double primary liver cancer (DPLC) is a special type of clinical situation. As such, a detailed analysis of the surgical management and prognosis of patients with DPLC is lacking. The objective of the current study was to define the management and outcome of patients undergoing surgery for DPLC at a major hepatobiliary center.A total of 87 patients treated by surgical resection at the Eastern Hepatobiliary Surgery Hospital from January 1st, 2007 to October 31st, 2013 who had DPLC demonstrated by final pathological diagnosis were identified...
August 2016: Medicine (Baltimore)
Yong Kang Lee, Kyu Sik Jung, Do Young Kim, Jin Young Choi, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Sang Hoon Ahn, Kwang-Hyub Han, Gyoung Min Kim, Man Deuk Kim, Sung Il Park, Jong Yun Won, Do Yun Lee
BACKGROUND & AIMS: To evaluate clinical outcomes of patients with hepatocellular carcinoma (HCC) who underwent trans-arterial chemoembolization (TACE) using drug-eluting beads (DEB). PATIENTS AND METHODS: We retrospectively compared the clinical outcomes of 250 consecutive patients who underwent DEB-TACE (n = 106) or conventional TACE (cTACE) (n = 144) in a tertiary center between January 2010 and April 2014. The median age of the patients was 62 years and 81...
August 9, 2016: Journal of Gastroenterology and Hepatology
Arnaud Monier, Boris Guiu, Rafael Duran, Serge Aho, Pierre Bize, Pierre Deltenre, Vincent Dunet, Alban Denys
OBJECTIVES: To compare transarterial chemoembolization (TACE)-related hepatic toxicities of conventional TACE (cTACE) and drug-eluting beads TACE (DEB-TACE) in patients with intermediate-stage hepatocellular carcinoma. METHODS: In this retrospective study, 151 consecutive patients undergoing cTACE or DEB-TACE and MRI 3-6 weeks before and after therapy were included. Toxicity was assessed on imaging (global hepatic damages (GHD), overall biliary injuries, biliary cast, bile duct dilatation, intrahepatic biloma, portal thrombosis), and clinico-biological follow-ups...
July 19, 2016: European Radiology
R Iezzi, M Pompili, M Nestola, M Siciliano, E Annicchiarico, M A Zocco, E Rinninella, A Posa, G E M Antonuccio, A Gasbarrini, L Bonomo
OBJECTIVE: To assess safety, feasibility and effectiveness of transarterial chemoembolization with degradable-starch-microspheres (DSM-TACE) in the treatment of patients with advanced hepatocellular carcinoma (HCC) dismissing or ineligible for multikinase-inhibitor chemotherapy administration (Sorafenib) due to unbearable side effects or clinical contraindications. PATIENTS AND METHODS: Six consecutive advanced HCC patients dismissing Sorafenib because of unbearable side effects or worsened clinical conditions were enrolled in our prospective single-center pilot study...
July 2016: European Review for Medical and Pharmacological Sciences
Qing-Hui Yang, Wen Zhang, Qing-Xin Liu, Ling-Xiao Liu, Lin-Lin Wu, Jian-Hua Wang, Zhi-Ping Yan, Jian-Jun Luo
PURPOSE: This study was designed to evaluate the safety and efficacy of transarterial chemoembolization (TACE) combined with intra-IVC implantation of an irradiation stent for the treatment of hepatocellular carcinoma (HCC) complicated by inferior vena cava tumor thrombosis (IVCTT). METHODS: Sixty-one consecutive patients with HCC complicated by IVCTT treated by TACE combined with IVC stenting were retrospectively analysed. IVC stenting was performed using a stent loaded with (125)I seeds strands (the irradiation stent) in 33 patients (Group A) and 28 patients with a bare stent (Group B)...
September 2016: Cardiovascular and Interventional Radiology
Shin Il Kim, Young-Joo Jin, Soon Gu Cho, Woo Young Shin, Joon Mee Kim, Jin-Woo Lee
Transarterial chemoembolization (TACE) is frequently used for treatment of unresectable hepatocellular carcinoma (HCC) and can also be used for case of liver metastases from rectal cancer. Although it is recognized as safe and effective treatment, various complications have been reported. However, post-TACE duodenal perforation with duodenal and esophageal ischemia has not been reported in the literature. A 43-year-old male had experienced duodenal perforation combined with duodenal and lower esophageal ischemia after 8 times of repeated TACE for recurrent and unresectable HCCs, that was confirmed on esophagogastroduodenoscopy and abdominal computed tomography...
July 2016: Medicine (Baltimore)
Mio Kitano, Gail W Davidson, Lawrence A Shirley, Carl R Schmidt, Gregory E Guy, Hooman Khabiri, Joshua D Dowell, Manisha H Shah, Mark Bloomston
BACKGROUND: Neuroendocrine tumors (NETs) have a propensity to metastasize to the liver, often resulting in massive tumor burden and hepatic dysfunction. While transarterial chemoembolization (TACE) is effective in treating patients with NET metastatic to the liver, there are limited data on its utility and benefit in patients with large hepatic involvement. The aim of our study was to determine the clinical benefit and complication rate of TACE in patients with massive hepatic tumor burden...
July 8, 2016: Annals of Surgical Oncology
Zeng-Bao Wu, Zeng-Mei Si, Sheng Qian, Ling-Xiao Liu, Xu-Dong Qu, Bo Zhou, Wei Zhang, Guang-Zhi Wang, Rong Liu, Jian-Hua Wang
BACKGROUND: The purpose of this study was to retrospectively evaluate the therapeutic efficacy and safety of ultrasound-guided percutaneous microwave ablation (MWA) combined with synchronous transcatheter arterial chemoembolization (TACE) in patients with colorectal liver metastases (CRLM). PATIENTS AND METHODS: A retrospective analysis was performed in 30 patients who were treated with ultrasound-guided percutaneous MWA combined with synchronous TACE for colorectal cancer liver metastases from November 2011 to December 2014 in Zhongshan Hospital, Fudan University...
2016: OncoTargets and Therapy
Ninggang Zheng, Xiaodong Wei, Dongzhi Zhang, Wenxiao Chai, Ming Che, Jiangye Wang, Binbin Du
The role of hepatic resection in hepatocellular carcinoma (HCC) with accompanying portal vein tumor thrombus (PVTT) remains controversial. This study aimed to evaluate the surgical outcomes of hepatic resection compared with those of transarterial chemoembolization (TACE) in HCC patients. A retrospective study was conducted using the medical records of 230 HCC patients with portal vein invasion who underwent hepatic resection (96 patients) or TACE (134 patients). The baseline characteristics, tumor characteristics, clinicopathological parameters, and overall survival rates were compared between the 2 groups...
June 2016: Medicine (Baltimore)
Yen-Wei Pai, Peiyuan F Hsieh, Hsin Tung, Chun-Ying Wu, Congo T S Ching, Ming-Hong Chang
OBJECTIVES: Transarterial chemoembolization (TACE) plays an essential role in the management of unresectable hepatocellular cell carcinoma and other hepatic neoplasms. Cerebral lipiodol embolism (CLE) is a rare complication of TACE and its prognostic factors have not been well studied. The aim of this paper was to elucidate the prognostic factors of CLE based on clinical data obtained from our patients and cases published since 2004. METHODS: We present two patients with CLE, analyze the clinical data, and review all CLE cases published since 2004...
October 2016: Neurological Research
Gianni Testino, Silvia Leone, Valentino Patussi, Emanuele Scafato, Paolo Borro
Hepatocellular carcinoma (HCC) ranks third for causes of cancer deaths globally. The most frequent causes are the hepatitis C virus (HCV), a combination of alcohol/HCV and metabolic syndrome (MS). The introduction of new pharmaceutical drugs that inhibit protease will bring a relative increase in the number of cases of HCC that are linked to the consumption of alcohol and MS. The latest development in the diagnostic sector is the total recognition of the CEUS diagnostic algorithm. In the treatment sector we are moving on from the Barcelona criteria...
June 28, 2016: Minerva Medica
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