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https://www.readbyqxmd.com/read/27904836/pulmonary-complications-of-transcatheter-arterial-chemoembolization-for-hepatocellular-carcinoma
#1
Quan M Nhu, Harry Knowles, Paul J Pockros, Catherine T Frenette
Transarterial chemoembolization (TACE) is an effective palliative intervention that is widely accepted for the management of hepatocellular carcinoma (HCC). Post-TACE pulmonary complications resulting in acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) are rare events. Pulmonary complications after TACE are thought to be related to chemical injury subsequent to the migration of the infused ethiodized oil or chemotherapeutic agent to the lung vasculature, facilitated by arteriovenous (AV) shunts within the hyper-vascular HCC...
2016: World Journal of Respirology
https://www.readbyqxmd.com/read/27904450/survival-of-patients-with-intermediate-stage-hepatocellular-carcinoma-treated-with-superselective-transarterial-chemoembolization-using-doxorubicin-loaded-dc-bead-under-cone-beam-computed-tomography-control
#2
Peter Popovic, Borut Stabuc, Rado Jansa, Manca Garbajs
BACKGROUND: The purpose of this retrospective study was to evaluate treatment response, adverse events and survival rates of patients with intermediate stage HCC treated with superselective doxorubicin-loaded DC Bead transarterial chemoembolization (DEBDOX) under cone beam computed tomography (CBCT) control. PATIENTS AND METHODS: Between October 2010 and June 2012, 35 consecutive patients with intermediate stage HCC (32 male, 3 female; average age, 67.5 ± 7.8 years; 22 patients Child-Pugh class A, 8 class B, 5 without cirrhosis) were treated with DEBDOX TACE...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27893491/role-of-low-molecular-weight-heparins-in-prevention-of-thromboembolic-complication-after-transarterial-chemoembolization-in-hepatocellular-carcinoma
#3
Osama Negm, Sabry Abou Saif, Mohamed El Gharib, Mohamed Yousef, Sherief Abd-Elsalam
BACKGROUND AND AIM: Portal vein thrombosis (PVT) is a common complication after transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC). This is the first clinical study to evaluate the role of low-molecular-weight heparins (LMWHs) with TACE in HCC for the prevention of thromboembolism complications (PVT). PATIENTS AND METHODS: This study was carried out on 40 patients with HCC requiring TACE who presented to the Tropical Medicine Department, Tanta University and Interventional Radiology Department of Ain-Shams University Hospitals starting from April 2015...
November 23, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27880724/hepatic-resection-after-transarterial-chemoembolization-increases-overall-survival-in-large-multifocal-hepatocellular-carcinoma-a-retrospective-cohort-study
#4
Junwei Chen, Lisha Lai, Qu Lin, Wensou Huang, Mingyue Cai, Kangshun Zhu, Mingsheng Huang
To investigate the prognosis of transarterial chemoembolization (TACE) followed by hepatic resection (HR) in large/multifocal hepatocellular carcinoma (HCC), the medical records of consecutive HCC patients who underwent TACE between January 2006 and December 2010 were retrospectively analyzed. Patients who received TACE alone comprised the T group (61 patients), while those who received HR after TACE comprised the T+R group (49 patients). All the resections were successfully performed, and only one class V complication occurred...
November 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27780939/chinese-expert-consensus-on-multidisciplinary-diagnosis-and-treatment-of-hepatocellular-carcinoma-with-portal-vein-tumor-thrombus-2016-edition
#5
REVIEW
Cheng Shuqun, Chen Minshan, Cai Jianqiang, The National Research Cooperative Group For Diagnosis And Treatment Of Hepatocellular Carcinoma With Tumor Thrombus
Hepatocellular carcinoma is the fourth leading cause of cancer-related morbidity and mortality in China. Portal vein tumor thrombus (PVTT) is common and it worsens prognosis of hepatocellular carcinoma (HCC). There is no internationally accepted consensus or guideline for diagnosis and treatment of HCC with PVTT. Based on existing evidences and common current practices, Chinese Experts on Multidisciplinary Diagnosis and Treatment of HCC with portal vein tumor thrombus met to develop a national consensus on diagnosis and treatment of HCC with PVTT...
October 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27766992/neoadjuvant-transcatheter-arterial-chemoembolization-for-biliary-tumor-thrombosis-a-retrospective-study
#6
Yangyang Shen, Pang Li, Kai Cui, Zhendan Wang, Fachang Yu, He Tian, Sheng Li
OBJECTIVES: Curative hepatectomy and tumor thrombectomy for hepatocellular carcinoma with complicating biliary tumor thrombosis (HCC/BTT) is associated with high surgical morbidity and mortality. This retrospective study evaluated the effectiveness and safety of neoadjuvant transcatheter arterial chemoembolization (TACE) in HCC/BTT patients scheduled for curative resection. METHODS: Thirty consecutive patients with diagnosed HCC/BTT were hospitalized for neoadjuvant TACE and elective curative liver resection (group A; n=20) or curative liver resection alone (group B; n=10)...
January 2016: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/27756646/serum-gamma-glutamyl-transferase-levels-affect-the-prognosis-of-patients-with-intrahepatic-cholangiocarcinoma-who-receive-postoperative-adjuvant-transcatheter-arterial-chemoembolization-a-propensity-score-matching-study
#7
Zhufeng Lu, Shuang Liu, Yong Yi, Xiaochun Ni, Jiaxing Wang, Jinlong Huang, Yipeng Fu, Ya Cao, Jian Zhou, Jia Fan, Shuangjian Qiu
BACKGROUND: The postoperative prognosis of patients with intrahepatic cholangiocarcinoma (ICC) is far from satisfactory. Whether postoperative adjuvant transcatheter arterial chemoembolization (TACE) is effective for patients with ICC after R0 liver resection remains controversial. MATERIALS AND METHODS: We retrospectively reviewed the data of 272 patients with ICC who received a radical hepatectomy at our center between 2000 and 2011. After the propensity score of postoperative TACE was calculated, 75 patients who received TACE were matched at a 1:2 ratios with 150 patients who did not receive TACE...
October 15, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27705924/a-mixed-analysis-comparing-nine-minimally-invasive-surgeries-for-unresectable-hepatocellular-carcinoma-patients
#8
Ran Tao, Xiaodan Li, Ruizhi Ran, Zhihua Xiao, Hongyue Zhang, Hongyan Kong, Qiqin Song, Yu Huang, Likui Wang, Jiaquan Huang
Hepatocellular carcinoma (HCC) is usually managed by the transcatheter arterial chemoembolization (TACE). However, this technique has been challenged since severe complications have been observed in clinical practices. As a result, clinicians have started to seek other minimally invasive surgeries with equivalent efficacy. The corresponding surgeries were assessed by the five outcomes: complete response (CR), partial response (PR), stable disease (SD), progression disease (PD) and objective response rate (ORR)...
September 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27698712/gelatin-sponge-microparticles-for-the-treatment-of-the-spontaneous-rupture-of-hepatocellular-carcinoma-hemorrhage
#9
Pu Zhao Wu, Jun Zhou, Yue Wei Zhang
Spontaneous rupture of hepatocellular carcinoma hemorrhage is life-threatening. The aim of the present study was to retrospectively analyze the effect of gelatin sponge microparticles (GSMs) of various diameters on the treatment of spontaneous rupture of hepatocellular carcinoma hemorrhage. GSMs serve as embolization agents by transcatheter arterial chemoembolization (TACE), and the current study analyzed their safety and efficacy. Data from a total of 13 cases of spontaneous rupture of hepatocellular carcinoma hemorrhage, who were treated with GSM-TACE at the Affiliated Zhongshan Hospital of Dalian University (Dalian, China) between August 2010 and June 2014, were collected...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27688061/microwave-ablation-for-hepatocellular-carcinoma-associated-with-budd-chiari-syndrome-after-transarterial-chemoembolization-an-analysis-of-ten-cases
#10
Jian-Ping Dou, Jie Yu, Zhi-Yu Han, Fang-Yi Liu, Zhi-Gang Cheng, Ping Liang
PURPOSE: To evaluate the feasibility, efficacy, and safety of microwave ablation (MWA) in the treatment of hepatocellular carcinoma associated with Budd-Chiari syndrome (BCS) after transarterial chemoembolization (TACE). METHODS: A total of 10 patients (mean 50.0 ± 7.5 years) with 15 BCS-associated HCC lesions were retrospectively evaluated. All patients received MWA treatment for residual tumors after 1 to 3 sessions of TACE. The diagnosis of residual tumors was confirmed by at least two types of enhanced imaging...
September 29, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27647003/rapid-virological-response-after-early-treatment-with-a-combined-therapy-of-ledipasvir-and-sofosbuvir-in-hcv-genotype-4-after-living-donor-liver-transplantation-in-a-hcc-downstaged-patient-case-report-and-review-of-the-literature
#11
Aiman Obed, Abdalla Bashir, Anwar Jarrad
BACKGROUND Hepatitis C virus (HCV) genotype 4 (GT-4) is widespread in the Middle East, where it is responsible for the majority of HCV infections. It shows moderate treatment response rates when compared to other genotypes in the current era of interferon-based regimens. However, in the era of direct acting antiviral (DAA) drugs, its response is at least as good as observed for HCV genotypes 1-3. CASE REPORT We present a case of a 44-year-old patient with HCV cirrhosis. Since 2007, he has been treated for HCV infection with multiple ineffective regimens of interferon (INF) and ribavirin...
September 20, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27634445/epidemiology-and-management-of-acute-kidney-injury-in-hepatocellular-carcinoma-patients-undergoing-transcatheter-arterial-chemoembolization
#12
Chen Xiaohong, Lv WenLv, Liu ZhongHua, Shen Bo, Cao XueSen, Nie YuXin, Yu JiaWei, Xu JiaRui, Ding XiaoQiang, Zou JianZhou
Transcatheter arterial chemoembolization (TACE) is an effective therapy for hepatocellular carcinoma (HCC). However, acute kidney injury (AKI) may occur after TACE due to the contrast agent and cytotoxic anticancer drugs used in this procedure. Post-TACE AKI is not an unusual event, and may adversely affect patient outcome. Coexisting situations including cirrhosis, renal insufficiency, diabetes and hypertension play a role in the development of HCC, and may predispose patients to AKI after TACE. Most post-TACE are transient and reversible, while prolonged AKI may predict a decreased survival...
September 9, 2016: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/27586657/unresectable-hepatocellular-carcinoma-radioembolization-versus-chemoembolization-a-systematic-review-and-meta-analysis
#13
Laila Lobo, Danny Yakoub, Omar Picado, Caroline Ripat, Fiorella Pendola, Rishika Sharma, Rana ElTawil, Deukwoo Kwon, Shree Venkat, Loraine Portelance, Raphael Yechieli
BACKGROUND: Transarterial radioembolization (TARE) has emerged as a newer regional therapy to transarterial chemoembolization (TACE) for treatment of unresectable hepatocellular carcinoma (HCC). The aim of this study is to compare clinical outcomes of both the techniques. METHODS: Online search for studies comparing TARE to TACE from 2005 to present was performed. Primary outcome was overall survival rate for up to 4 years. Secondary outcomes included post-treatment complications and treatment response...
November 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27575338/aggressive-intrasegmental-recurrence-of-hepatocellular-carcinoma-after-combined-transarterial-chemoembolization-and-radiofrequency-ablation
#14
Kyoung Doo Song, Min Woo Lee, Hyunchul Rhim, Young-Sun Kim, Tae Wook Kang, Sung Wook Shin, Sung Ki Cho
OBJECTIVE: The goal of this study is to evaluate the outcomes of combined transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) in terms of the frequency of aggressive intrasegmental recurrence. MATERIALS AND METHODS: Sixty-one patients (43 men and 18 women; mean [± SD] age, 65.8 ± 8.6 years; age range, 44-82 years) with 71 HCCs (mean [± SD] size, 2.8 ± 0.9 cm; range, 0.7-4.2 cm) underwent combined TACE and RFA...
November 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27558984/chemoembolization-with-drug-eluting-beads-preloaded-with-irinotecan-debiri-vs-doxorubicin-debdox-as-a-second-line-treatment-for-liver-metastases-from-cholangiocarcinoma-a-preliminary-study
#15
Massimo Venturini, Claudio Sallemi, Giulia Agostini, Paolo Marra, Stefano Cereda, Michele Reni, Luca Aldrighetti, Francesco De Cobelli, Alessandro Del Maschio
OBJECTIVES: Aim of our preliminary study was to compare the efficacy of DEBIRI vs. DEBDOX as second line treatment of unresectable liver metastases from cholangiocarcinoma. METHODS: In 2013, 10 patients affected by multiple liver metastases from cholangiocarcinoma, resistant to the first line chemotherapy regimen, were enrolled: 5 were submitted to lobar/segmental TACE with DEBIRI (100mg Irinotecan/1vial) and 5 with DEBDOX (50mg Doxorubicin/1vial), performed every 3 weeks...
August 25, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27536066/chinese-herbal-medicine-jianpi-ligan-decoction-improves-prognosis-of-unresectable-hepatocellular-carcinoma-after-transarterial-chemoembolization-a-retrospective-study
#16
Cheng Wu Tang, Ming Zhu, Wen Ming Feng, Ying Bao, Yin Yuan Zheng
OBJECTIVE: This study aimed to investigate the efficacy of Jianpi Ligan decoction (JLD) as an adjuvant therapy for patients with unresectable hepatocellular carcinoma (HCC) treated by transarterial chemoembolization (TACE). METHODS: From March 2007 to March 2013, 103 patients with unresectable HCC who underwent TACE in our center were included in this retrospective study. Among the 103 patients, 53 patients accepted JLD along with TACE (JLD group) and 50 patients accepted TACE alone (control group)...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27512855/surgical-treatment-of-double-primary-liver-cancer-an-observational-study-for-a-rare-type-of-tumor
#17
Aijun Li, Senlin Ma, Timothy Pawlik, Bin Wu, Xiaoyu Yang, Longjiu Cui, Mengchao Wu
Double primary liver cancer (DPLC) is a special type of clinical situation. As such, a detailed analysis of the surgical management and prognosis of patients with DPLC is lacking. The objective of the current study was to define the management and outcome of patients undergoing surgery for DPLC at a major hepatobiliary center.A total of 87 patients treated by surgical resection at the Eastern Hepatobiliary Surgery Hospital from January 1st, 2007 to October 31st, 2013 who had DPLC demonstrated by final pathological diagnosis were identified...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27503585/tumor-size-might-not-distinguish-outcomes-between-conventional-and-drug-eluting-chemoembolization-for-hepatocellular-carcinoma
#18
Yong Kang Lee, Kyu Sik Jung, Do Young Kim, Jin Young Choi, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Sang Hoon Ahn, Kwang-Hyub Han, Gyoung Min Kim, Man Deuk Kim, Sung Il Park, Jong Yun Won, Do Yun Lee
BACKGROUND & AIMS: To evaluate clinical outcomes of patients with hepatocellular carcinoma (HCC) who underwent trans-arterial chemoembolization (TACE) using drug-eluting beads (DEB). PATIENTS AND METHODS: We retrospectively compared the clinical outcomes of 250 consecutive patients who underwent DEB-TACE (n = 106) or conventional TACE (cTACE) (n = 144) in a tertiary center between January 2010 and April 2014. The median age of the patients was 62 years and 81...
August 9, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27436016/liver-and-biliary-damages-following-transarterial-chemoembolization-of-hepatocellular-carcinoma-comparison-between-drug-eluting-beads-and-lipiodol-emulsion
#19
Arnaud Monier, Boris Guiu, Rafael Duran, Serge Aho, Pierre Bize, Pierre Deltenre, Vincent Dunet, Alban Denys
OBJECTIVES: To compare transarterial chemoembolization (TACE)-related hepatic toxicities of conventional TACE (cTACE) and drug-eluting beads TACE (DEB-TACE) in patients with intermediate-stage hepatocellular carcinoma. METHODS: In this retrospective study, 151 consecutive patients undergoing cTACE or DEB-TACE and MRI 3-6 weeks before and after therapy were included. Toxicity was assessed on imaging (global hepatic damages (GHD), overall biliary injuries, biliary cast, bile duct dilatation, intrahepatic biloma, portal thrombosis), and clinico-biological follow-ups...
July 19, 2016: European Radiology
https://www.readbyqxmd.com/read/27424988/transarterial-chemoembolization-with-degradable-starch-microspheres-dsm-tace-an-alternative-option-for-advanced-hcc-patients-preliminary-results
#20
R Iezzi, M Pompili, M Nestola, M Siciliano, E Annicchiarico, M A Zocco, E Rinninella, A Posa, G E M Antonuccio, A Gasbarrini, L Bonomo
OBJECTIVE: To assess safety, feasibility and effectiveness of transarterial chemoembolization with degradable-starch-microspheres (DSM-TACE) in the treatment of patients with advanced hepatocellular carcinoma (HCC) dismissing or ineligible for multikinase-inhibitor chemotherapy administration (Sorafenib) due to unbearable side effects or clinical contraindications. PATIENTS AND METHODS: Six consecutive advanced HCC patients dismissing Sorafenib because of unbearable side effects or worsened clinical conditions were enrolled in our prospective single-center pilot study...
July 2016: European Review for Medical and Pharmacological Sciences
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