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https://www.readbyqxmd.com/read/28921647/pharmacogenomics-implementation-at-the-national-institutes-of-health-clinical-center
#1
Tristan M Sissung, Jon W McKeeby, Jharana Patel, Juan J Lertora, Parag Kumar, Willy A Flegel, Sharon D Adams, Ellen J Eckes, Frank Mickey, Teri M Plona, Stephanie D Mellot, Ryan N Baugher, Xiaolin Wu, Daniel R Soppet, Mary E Barcus, Vivekananda Datta, Kristen M Pike, Gary DiPatrizio, William D Figg, Barry R Goldspiel
The National Institutes of Health Clinical Center (NIH CC) is the largest hospital in the United States devoted entirely to clinical research, with a highly diverse spectrum of patients. Patient safety and clinical quality are major goals of the hospital, and therapy is often complicated by multiple cotherapies and comorbidities. To this end, we implemented a pharmacogenomics program in 2 phases. In the first phase, we implemented genotyping for HLA-A and HLA-B gene variations with clinical decision support (CDS) for abacavir, carbamazepine, and allopurinol...
October 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28920708/perceived-usefulness-and-perceived-ease-of-use-of-electronic-health-records-among-nurses-application-of-technology-acceptance-model
#2
Ahmad Tubaishat
BACKGROUND: Electronic health records (EHRs) are increasingly being implemented in healthcare organizations but little attention has been paid to the degree to which nurses as end-users will accept these systems and subsequently use them. OBJECTIVES: To explore nurses' perceptions of usefulness and ease-of-use of EHRs. The relationship between these constructs was examined, and its predictors were studied. METHOD: A national exploratory study was conducted with 1539 nurses from 15 randomly selected hospitals, representative of different regions and healthcare sectors in Jordan...
September 18, 2017: Informatics for Health & Social Care
https://www.readbyqxmd.com/read/28918322/time-for-tiger-to-roar-technology-informatics-guiding-education-reform
#3
EDITORIAL
Siobhan O'Connor, Ursula Hubner, Toria Shaw, Rachelle Blake, Marion Ball
Information Technology (IT) continues to evolve and develop with electronic devices and systems becoming integral to healthcare in every country. This has led to an urgent need for all professions working in healthcare to be knowledgeable and skilled in informatics. The Technology Informatics Guiding Education Reform (TIGER) Initiative was established in 2006 in the United States to develop key areas of informatics in nursing. One of these was to integrate informatics competencies into nursing curricula and life-long learning...
August 19, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28916932/informatics-for-nutritional-genetics-and-genomics
#4
Yuan Gao, Jiajia Chen
While traditional nutrition science is focusing on nourishing population, modern nutrition is aiming at benefiting individual people. The goal of modern nutritional research is to promote health, prevent diseases, and improve performance. With the development of modern technologies like bioinformatics, metabolomics, and molecular genetics, this goal is becoming more attainable. In this chapter, we will discuss the new concepts and technologies especially in informatics and molecular genetics and genomics, and how they have been implemented to change the nutrition science and lead to the emergence of new branches like nutrigenomics, nutrigenetics, and nutritional metabolomics...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28916926/informatics-for-precision-medicine-and-healthcare
#5
Jiajia Chen, Yuxin Lin, Bairong Shen
The past decade has witnessed great advances in biomedical informatics. Biomedical informatics is an emerging field of healthcare that aims to translate the laboratory observation into clinical practice. Smart healthcare has also developed rapidly with ubiquitous sensor and communication technologies. It is able to capture the online patient-centric phenotypic variables, thus providing a rich information base for translational biomedical informatics. Biomedical informatics and smart healthcare represent two interrelated disciplines...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28913742/automated-morphological-and-morphometric-analysis-of-mass-spectrometry-imaging-data-application-to-biomarker-discovery
#6
Gaël Picard de Muller, Rima Ait-Belkacem, David Bonnel, Rémi Longuespée, Jonathan Stauber
Mass spectrometry imaging datasets are mostly analyzed in terms of average intensity in regions of interest. However, biological tissues have different morphologies with several sizes, shapes, and structures. The important biological information, contained in this highly heterogeneous cellular organization, could be hidden by analyzing the average intensities. Finding an analytical process of morphology would help to find such information, describe tissue model, and support identification of biomarkers. This study describes an informatics approach for the extraction and identification of mass spectrometry image features and its application to sample analysis and modeling...
September 14, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28913416/using-focused-laboratory-management-and-quality-improvement-projects-to-enhance-resident-training-and-foster-scholarship
#7
Matthew D Krasowski, Bradley A Ford, J Stacey Klutts, Chris S Jensen, Angela S Briggs, Robert A Robinson, Leslie A Bruch, Nitin J Karandikar
Training in patient safety, quality, and management is widely recognized as an important element of graduate medical education. These concepts have been intertwined in pathology graduate medical education for many years, although training programs face challenges in creating explicit learning opportunities in these fields. Tangibly involving pathology residents in management and quality improvement projects has the potential to teach and reinforce key concepts and further fulfill Accreditation Council for Graduate Medical Education goals for pursuing projects related to patient safety and quality improvement...
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28912709/extending-xnat-platform-with-an-incremental-semantic-framework
#8
Santiago Timón, Mariano Rincón, Rafael Martínez-Tomás
Informatics increases the yield from neuroscience due to improved data. Data sharing and accessibility enable joint efforts between different research groups, as well as replication studies, pivotal for progress in the field. Research data archiving solutions are evolving rapidly to address these necessities, however, distributed data integration is still difficult because of the need of explicit agreements for disparate data models. To address these problems, ontologies are widely used in biomedical research to obtain common vocabularies and logical descriptions, but its application may suffer from scalability issues, domain bias, and loss of low-level data access...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28903894/prototype-development-context-driven-dynamic-xml-ophthalmologic-data-capture-application
#9
Peggy Peissig, Kelsey M Schwei, Christopher Kadolph, Joseph Finamore, Efrain Cancel, Catherine A McCarty, Asha Okorie, Kate L Thomas, Jennifer Allen Pacheco, Jyotishman Pathak, Stephen B Ellis, Joshua C Denny, Luke V Rasmussen, Gerard Tromp, Marc S Williams, Tamara R Vrabec, Murray H Brilliant
BACKGROUND: The capture and integration of structured ophthalmologic data into electronic health records (EHRs) has historically been a challenge. However, the importance of this activity for patient care and research is critical. OBJECTIVE: The purpose of this study was to develop a prototype of a context-driven dynamic extensible markup language (XML) ophthalmologic data capture application for research and clinical care that could be easily integrated into an EHR system...
September 13, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28903073/reconciling-disparate-information-in-continuity-of-care-documents-piloting-a-system-to-consolidate-structured-clinical-documents
#10
Masoud Hosseini, Josette Jones, Anthony Faiola, Daniel J Vreeman, Huanmei Wu, Brian E Dixon
BACKGROUND: Due to the nature of information generation in health care, clinical documents contain duplicate and sometimes conflicting information. Recent implementation of health information exchange (HIE) mechanisms in which clinical summary documents are exchanged among disparate health care organizations can proliferate duplicate and conflicting information. MATERIALS AND METHODS: To reduce information overload, a system to automatically consolidate information across multiple clinical summary documents was developed for an HIE network...
September 10, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28902453/implementing-a-web-based-introductory-bioinformatics-course-for-non-bioinformaticians-that-incorporates-practical-exercises
#11
Antony T Vincent, Yves Bourbonnais, Jean-Simon Brouard, Hélène Deveau, Arnaud Droit, Stéphane M Gagné, Michel Guertin, Claude Lemieux, Louis Rathier, Steve J Charette, Patrick Lagüe
A recent scientific discipline, bioinformatics, defined as using informatics for the study of biological problems, is now a requirement for the study of biological sciences. Bioinformatics has become such a powerful and popular discipline that several academic institutions have created programs in this field, allowing students to become specialized. However, biology students who are not involved in a bioinformatics program also need a solid toolbox of bioinformatics software and skills. Therefore, we have developed a completely online bioinformatics course for non-bioinformaticians, entitled "BIF-1901 Introduction à la bio-informatique et à ses outils (Introduction to bioinformatics and bioinformatics tools)," given by the Department of Biochemistry, Microbiology, and Bioinformatics of Université Laval (Quebec City, Canada)...
September 13, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28901628/total-cosine-r-to-t-for-predicting-ventricular-arrhythmic-and-mortality-outcomes-a-systematic-review-and-meta-analysis
#12
Gary Tse, Mengqi Gong, Cheuk Wai Wong, Cynthia Chan, Stamatis Georgopoulos, Yat Sun Chan, Bryan P Yan, Guangping Li, Paula Whittaker, Ana Ciobanu, Sadeq Ali-Hasan-Al-Saegh, Sunny H Wong, William K K Wu, George Bazoukis, Konstantinos Lampropoulos, Wing Tak Wong, Lap Ah Tse, Adrian M Baranchuk, Konstantinos P Letsas, Tong Liu
BACKGROUND: The total cosine R-to-T (TCRT), a vectorcardiographic marker reflecting the spatial difference between the depolarization and repolarization wavefronts, has been used to predict ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death (SCD) in different clinical settings. However, its prognostic value has been controversial. OBJECTIVE: This systematic review and meta-analysis evaluated the significance of TRCT in predicting arrhythmic and/or mortality endpoints...
September 12, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28895104/concordance-of-adherence-measurement-using-self-reported-adherence-questionnaires-and-medication-monitoring-devices-an-updated-review
#13
REVIEW
Alisha Monnette, Yichen Zhang, Hui Shao, Lizheng Shi
INTRODUCTION: As medication adherence continues to be a prevalent issue in today's society, the methods used to monitor medication-taking behaviors are constantly being re-evaluated and compared in search of the 'gold standard' measure. Our review aimed to assess the current literature surrounding the correlation between self-reported questionnaires (SRQs) and electronic monitoring devices to determine if these measures produce similar results. METHODS: We performed a literature search from 2009 to 2017 using PubMed, PubMed In-Process and Non-Indexed, EMBASE, Ovid MEDLINE, and Ovid MEDLINE In-Process...
September 11, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28894721/the-applications-of-health-informatics-in-medical-tourism-industry-of-iran
#14
Peyman Rezaei-Hachesu, Reza Safdari, Marjan Ghazisaeedi, Taha Samad-Soltani
No abstract text is available yet for this article.
August 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28892623/use-of-crystal-structure-informatics-for-defining-the-conformational-space-needed-for-predicting-crystal-structures-of-pharmaceutical-molecules
#15
Luca Iuzzolino, Anthony Martin Reilly, Patrick McCabe, Sarah L Price
Determining the range of conformations that a flexible pharmaceutical-like molecule could plausibly adopt in a crystal structure is a key to successful crystal structure prediction (CSP) studies. We aim to use conformational information from the crystal structures in the Cambridge Structural Database (CSD) to facilitate this task. The conformations produced by the CSD Conformer Generator are reduced in number by considering the underlying rotamer distributions, an analysis of changes in molecular shape, and a minimal number of molecular ab initio calculations...
September 11, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28891675/abstracts-the-society-of-biomolecular-imaging-and-informatics-4th-annual-meeting-poster-session-september-13-15-2017-san-diego-convention-center-san-diego-ca
#16
(no author information available yet)
No abstract text is available yet for this article.
September 11, 2017: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/28885237/exploring-the-perceived-value-of-a-personalized-informatics-tool-to-anticipate-and-mitigate-patient-risk
#17
Michael D Kneeland, Catherine H Ivory, Phebe Bloomingburg, Neesha N Choma
Health care systems are implementing a myriad of strategies to improve patient outcomes and reduce both adverse events and unplanned readmissions. These approaches include interventions related to people, processes, and technology. This article describes the development of a technology-based model in the form of an actionable risk profile, which was used by one inpatient surgical unit (people) during a daily care team briefing (process). The risk profile was evaluated for its perceived value to the care team as a method of organizing care and anticipating patients' needs...
September 1, 2017: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/28884111/rotator-cuff-repair-in-the-brazilian-unified-health-system-brazilian-trends-from-2003-to-2015
#18
Eduardo Angeli Malavolta, Jorge Henrique Assunção, Rodrigo Alves Beraldo, Gustavo de Mello Ribeiro Pinto, Mauro Emilio Conforto Gracitelli, Arnaldo Amado Ferreira Neto
OBJECTIVE: To assess the historical trend of rotator cuff repairs in Brazil between 2003 and 2015, using the database of the Brazilian Unified Health System's (Sistema Único de Saúde [SUS]) Department of Informatics (DataSUS). METHODS: Historical series using DataSUS. Surgeries performed between 2003 and 2015 were included and data relating to cuff tear repair were assessed, including decompression procedures were included. The numerator was the total number of rotator cuff repair and the denominator, the total population of the assessed locality...
June 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28883683/the-most-influential-scientist-in-the-development-of-medical-informatics-17-eugene-garfield
#19
Izet Masic
No abstract text is available yet for this article.
June 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28883670/medical-informatics-as-academic-and-scientific-discipline-in-bosnia-and-herzegovina-twenty-five-years-of-experiences-from-faculty-of-medicine-university-of-sarajevo
#20
EDITORIAL
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