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https://www.readbyqxmd.com/read/28724368/utilizing-patient-data-from-the-veterans-administration-electronic-health-record-to-support-web-based-clinical-decision-support-informatics-challenges-and-issues-from-three-clinical-domains
#1
Nallakkandi Rajeevan, Kristina M Niehoff, Peter Charpentier, Forrest L Levin, Amy Justice, Cynthia A Brandt, Terri R Fried, Perry L Miller
BACKGROUND: The US Veterans Administration (VA) has developed a robust and mature computational infrastructure in support of its electronic health record (EHR). Web technology offers a powerful set of tools for structuring clinical decision support (CDS) around clinical care. This paper describes informatics challenges and design issues that were confronted in the process of building three Web-based CDS systems in the context of the VA EHR. METHODS: Over the course of several years, we implemented three Web-based CDS systems that extract patient data from the VA EHR environment to provide patient-specific CDS...
July 19, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28720677/synthetic-circulating-cell-free-dna-as-quality-control-materials-for-somatic-mutation-detection-in-liquid-biopsy-for-cancer
#2
Rui Zhang, Rongxue Peng, Ziyang Li, Peng Gao, Shiyu Jia, Xin Yang, Jiansheng Ding, Yanxi Han, Jiehong Xie, Jinming Li
BACKGROUND: Detection of somatic genomic alterations in tumor-derived cell-free DNA (cfDNA) in the plasma is challenging owing to the low concentrations of cfDNA, variable detection methods, and complex workflows. Moreover, no proper quality control materials are available currently. METHODS: We developed a set of synthetic cfDNA quality control materials (SCQCMs) containing spike-in cfDNA on the basis of micrococcal nuclease digestion carrying somatic mutations as simulated cfDNA and matched genomic DNA as genetic background to emulate paired tumor-normal samples in real clinical tests...
July 18, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28717332/homology-modeling-of-leishmania-donovani-enolase-and-its-molecular-interaction-with-novel-inhibitors
#3
Jay Prakash Mahato, Sindhuprava Rana, Maneesh Kumar, Surendra Sarsaiya
INTRODUCTION: The treatment of Indian tropical disease such as kala-azar is likely to be troublesome to the clinicians as AmpB- and miltefosine-resistant Leishmania donovani has been reported. The rationale behind designed a novel inhibitors of model of L. donovani enolase and performing a binding study with its inhibitors to gain details of the interaction between protein residues and ligand molecules. METHODS AND MATERIALS: The L. donovani enolase model consists of two typical domains...
April 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28710229/pirate-project-point-of-care-informatics-based-randomised-controlled-trial-for-decreasing-overuse-of-antibiotic-therapy-in-gram-negative-bacteraemia
#4
Angela Huttner, Werner C Albrich, Pierre-Yves Bochud, Angèle Gayet-Ageron, Anne Rossel, Elodie von Dach, Stephan Harbarth, Laurent Kaiser
INTRODUCTION: Antibiotic overuse drives antibiotic resistance. The optimal duration of antibiotic therapy for Gram-negative bacteraemia (GNB), a common community and hospital-associated infection, remains unknown and unstudied via randomised controlled trials (RCTs). METHODS AND ANALYSIS: This investigator-initiated, multicentre, non-inferiority, informatics-based point-of-care RCT will randomly assign adult hospitalised patients receiving microbiologically efficacious antibiotic(s) for GNB to (1) 14 days of antibiotic therapy, (2) 7 days of therapy or (3) an individualised duration determined by clinical response and 75% reduction in peak C reactive protein (CRP) values...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28706066/snap-deconvolution-an-informatics-approach-to-high-throughput-discovery-of-catalytic-reactions
#5
Konstantin Troshin, John F Hartwig
We present an approach to multidimensional high-throughput discovery of catalytic coupling reactions that integrates molecular design with automated analysis and interpretation of mass spectral data. We simultaneously assessed the reactivity of three pools of compounds that shared the same functional groups (halides, boronic acids, alkenes, and alkynes, among other groups) but carried inactive substituents having specifically designed differences in masses. The substituents were chosen such that the products from any class of reaction in multiple reaction sets would have unique differences in masses, thus allowing simultaneous identification of the products of all transformations in a set of reactants...
July 14, 2017: Science
https://www.readbyqxmd.com/read/28701226/the-application-of-geographic-information-systems-gis-in-identifying-the-priority-areas-for-maternal-care-and-services
#6
Fatemeh Salehi, Leila Ahmadian
BACKGROUND: Improving maternal health is globally introduced as an important health priority. The purpose of this study is to identify the high priority areas which require more maternal health services in Kerman, Iran. METHODS: This is a descriptive cross-sectional study, performed in 2015. The literatures were first explored in order to extract geographic indicators and sub indicators relevant to the maternal health. Data were collected by the use of a questionnaire designed on the basis of AHP (Analytic Hierarchy Process) method...
July 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28699553/introduction-the-international-conference-on-intelligent-biology-and-medicine-icibm-2016-special-focus-on-medical-informatics-and-big-data
#7
Cui Tao, Yang Gong, Hua Xu, Zhongming Zhao
In this editorial, we first summarize the 2016 International Conference on Intelligent Biology and Medicine (ICIBM 2016) held on December 8-10, 2016 in Houston, Texas, USA, and then briefly introduce the ten research articles included in this supplement issue. At ICIBM 2016, a special theme, "Medical Informatics and Big Data," was dedicated to the recent advances of data science in the medical domain. After peer review, ten articles were selected for this special issue, covering topics such as Knowledge and Data Personalization, Social Media Applications to Healthcare, Clinical Natural Language Processing, Patient Safety Analyses, and Data Mining Using Electronic Health Records...
July 5, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28692395/a-practitioner-driven-research-agenda-for-syndromic-surveillance
#8
Richard S Hopkins, Catherine C Tong, Howard S Burkom, Judy E Akkina, John Berezowski, Mika Shigematsu, Patrick D Finley, Ian Painter, Roland Gamache, Victor J Del Rio Vilas, Laura C Streichert
Syndromic surveillance has expanded since 2001 in both scope and geographic reach and has benefited from research studies adapted from numerous disciplines. The practice of syndromic surveillance continues to evolve rapidly. The International Society for Disease Surveillance solicited input from its global surveillance network on key research questions, with the goal of improving syndromic surveillance practice. A workgroup of syndromic surveillance subject matter experts was convened from February to June 2016 to review and categorize the proposed topics...
July 2017: Public Health Reports
https://www.readbyqxmd.com/read/28691345/the-skyline-ecosystem-informatics-for-quantitative-mass-spectrometry-proteomics
#9
REVIEW
Lindsay K Pino, Brian C Searle, James G Bollinger, Brook Nunn, Brendan MacLean, Michael J MacCoss
Skyline is a freely available, open-source Windows client application for accelerating targeted proteomics experimentation, with an emphasis on the proteomics and mass spectrometry community as users and as contributors. This review covers the informatics encompassed by the Skyline ecosystem, from computationally assisted targeted mass spectrometry method development, to raw acquisition file data processing, and quantitative analysis and results sharing.
July 9, 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/28691115/toward-a-digital-thread-and-data-package-for-metals-additive-manufacturing
#10
D B Kim, P Witherell, Y Lu, S Feng
Additive manufacturing (AM) has been envisioned by many as a driving factor of the next industrial revolution. Potential benefits of AM adoption include the production of low-volume, customized, complicated parts/products, supply chain efficiencies, shortened time-to-market, and environmental sustainability. Work remains, however, for AM to reach the status of a full production-ready technology. Whereas the ability to create unique 3D geometries has been generally proven, production challenges remain, including lack of (1) data manageability through information management systems, (2) traceability to promote product producibility, process repeatability, and part-to-part reproducibility, and (3) accountability through mature certification and qualification methodologies...
2017: Smart Sustain Manuf Syst
https://www.readbyqxmd.com/read/28688561/uncovering-the-pathogenesis-of-microtia-using-bioinformatics-approach
#11
Liu Lei, Liu Zhenzhong, Lin Lin, Pan Bo
OBJECTIVE: Bioinformatics is widely used in the field of cancer research, but in the research of pathogenesis of congenital malformations the situation is different. The aim of this study was to explore the underlying mechanism using bioinformatics approach. METHODS: The data were available from Mouse Genome Informatics and Pubmed. Protein-protein interaction (PPI) network of pathogenic genes was conducted using STRING. Gene ontology and pathway enrichment analyses were also performed to pathogenic genes...
August 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28688028/novel-assessment-of-interstitial-lung-disease-using-the-computer-aided-lung-informatics-for-pathology-evaluation-and-rating-caliper-software-system-in-idiopathic-inflammatory-myopathies
#12
Patompong Ungprasert, Katelynn M Wilton, Floranne C Ernste, Sanjay Kalra, Cynthia S Crowson, Srinivasan Rajagopalan, Brian J Bartholmai
PURPOSE: To evaluate the correlation between measurements from quantitative thoracic high-resolution CT (HRCT) analysis with "Computer-Aided Lung Informatics for Pathology Evaluation and Rating" (CALIPER) software and measurements from pulmonary function tests (PFTs) in patients with idiopathic inflammatory myopathies (IIM)-associated interstitial lung disease (ILD). METHODS: A cohort of patients with IIM-associated ILD seen at Mayo Clinic was identified from medical record review...
July 7, 2017: Lung
https://www.readbyqxmd.com/read/28684387/sharing-annotated-audio-recordings-of-clinic-visits-with-patients-development-of-the-open-recording-automated-logging-system-orals-study-protocol
#13
Paul J Barr, Michelle D Dannenberg, Craig H Ganoe, William Haslett, Rebecca Faill, Saeed Hassanpour, Amar Das, Roger Arend, Meredith C Masel, Sheryl Piper, Haley Reicher, James Ryan, Glyn Elwyn
BACKGROUND: Providing patients with recordings of their clinic visits enhances patient and family engagement, yet few organizations routinely offer recordings. Challenges exist for organizations and patients, including data safety and navigating lengthy recordings. A secure system that allows patients to easily navigate recordings may be a solution. OBJECTIVE: The aim of this project is to develop and test an interoperable system to facilitate routine recording, the Open Recording Automated Logging System (ORALS), with the aim of increasing patient and family engagement...
July 6, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28684129/chemokine-isoforms-and-processing-in-inflammation-and-immunity
#14
REVIEW
Paul Proost, Sofie Struyf, Jo Van Damme, Pierre Fiten, Estefania Ugarte-Berzal, Ghislain Opdenakker
The first dimension of chemokine heterogeneity is reflected by their discovery and purification as natural proteins. Each of those chemokines attracted a specific inflammatory leukocyte type. With the introduction of genomic technologies, a second wave of chemokine heterogeneity was established by the discovery of putative chemokine-like sequences and by demonstrating chemotactic activity of the gene products in physiological leukocyte homing. In the postgenomic era, the third dimension of chemokine heterogeneity is the description of posttranslational modifications on most chemokines...
July 3, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28681659/the-relationship-of-genetics-nursing-practice-and-informatics-tools-in-6-mercaptopurine-dosing-in-pediatric-oncology
#15
Wendy J Haylett
An antileukemic agent prescribed for pediatric oncology patients during the maintenance phase of therapy for acute lymphoblastic leukemia, 6-mercaptopurine (6-MP), is highly influenced by genetic variations in the thiopurine S-methyltransferase enzyme. As such, 6-MP must be dosed so that patients with 1 or 2 inactive thiopurine S-methyltransferase alleles will not incur an increased risk for myelosuppression or other toxicities. Informatics tools such as clinical decision support systems are useful for the application of this and similar pharmacogenetics information to the realm of nursing and clinical practice for safe and effective patient care...
July 1, 2017: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/28681416/risk-of-angioedema-associated-with-levetiracetam-compared-with-phenytoin-findings-of-the-observational-health-data-sciences-and-informatics-research-network
#16
Jon D Duke, Patrick B Ryan, Marc A Suchard, George Hripcsak, Peng Jin, Christian Reich, Marie-Sophie Schwalm, Yuriy Khoma, Yonghui Wu, Hua Xu, Nigam H Shah, Juan M Banda, Martijn J Schuemie
Recent adverse event reports have raised the question of increased angioedema risk associated with exposure to levetiracetam. To help address this question, the Observational Health Data Sciences and Informatics research network conducted a retrospective observational new-user cohort study of seizure patients exposed to levetiracetam (n = 276,665) across 10 databases. With phenytoin users (n = 74,682) as a comparator group, propensity score-matching was conducted and hazard ratios computed for angioedema events by per-protocol and intent-to-treat analyses...
July 6, 2017: Epilepsia
https://www.readbyqxmd.com/read/28679943/an-overview-of-the-biomed-project
#17
John Mantas, Mohamed A Wageih
The purpose is to: 1) foster the national BioMedical Informatics (BMI) foundation aligning with the international medical informatics association (IMIA) in order to remodel the national strategies; 2) structure the BMHI strategic plans in Egypt and Jordan as models for other Arab States; 3) define the requirements for new joint EU-Mediterranean BMHI projects and initiatives; and 4) encourage and support the BMHI centres of excellence in Egypt and Jordan. BIOMed will synergistically apply up-to-date European and International methodologies & standards...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28679942/accreditation-and-certification-in-health-informatics-principles-and-procedures
#18
John Mantas
Accreditation is an important process ensuring quality of academic programs in Biomedical Informatics. Certification ensures standards in knowledge and skills of professionals in Health Informatics. The process of Accreditation is analyzed for its pros and cons. Procedures are applied to ensure the completion of accreditation of a program is transparent, objective and leads in quality qualifications. Finally, the logistics required for Accreditation are calculated in terms of human resources as well to meeting cost expectations...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28679941/continuous-education-in-community-nursing-with-the-use-of-health-informatics
#19
Kostis Chardalias, Andrianna Magnita, Charalampos Andrianopoulos, Panagiotis Koutonias, Antonis Kefaliakos, Marianna Diomidous
Continuous Education can make a significant progress in any professional scientific discipline such as Nursing, which is constantly evolving. The main purpose of this paper is the review of contemporary literature in relation to the continuous education in community-nursing, with the use of health informatics. Additionally, these reasons are examined for which, nurses attend or not programs of continuing education. Finally, Accreditation, Interdisciplinary Education and Nursing Education to provide in the best possible way the necessary knowledge to students, is highlighted...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28679938/managing-information-more-effectively-in-health-informatics-applications
#20
Rodolfo A Fiorini
Conceptual clarity and predicative/impredicative competence are the fundamental components for managing information more effectively in Health Informatics, Healthcare and Medicine applications, while promoting innovation and creativity. Medicine was always the art and science of healing. The science became more and more a mechanistic technology in Healthcare; the art was dropped altogether. But uncertainty-as-problem in the past is slowly morphing into the evolutive concept of uncertainty-as-resource. The key change performance factor is education, distinguishing building on sand from building on rock for Health Informatics! Conceptual clarity, more than instrumental obsession (so typical of this particular time) is necessary...
2017: Studies in Health Technology and Informatics
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