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https://www.readbyqxmd.com/read/29103678/cytotoxic-activity-of-flavobacterium-psychrophilum-in-skeletal-muscle-cells-of-rainbow-trout-oncorhynchus-mykiss
#1
Mathias Iturriaga, Marlen Brisa Espinoza, Matías Poblete-Morales, Carmen Gloria Feijoo, Ariel E Reyes, Alfredo Molina, Ruben Avendaño-Herrera, Juan Antonio Valdés
Flavobacterium psychrophilum is the etiologic agent of bacterial coldwater disease (BCWD) and rainbow trout fry syndrome (RTFS), which cause significant worldwide losses in aquaculture. Juvenile rainbow trout are particularly susceptible to F. psychrophilum infection, the main external clinical signs of which are extensive necrotic myositis and ulcerative lesions. Despite the economic relevance of this pathogen in aquaculture, little is known about the molecular mechanisms underlying F. psychrophilum infection and pathogenesis...
October 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29099111/subtle-metabolic-alterations-in-adolescents-with-obesity-and-polycystic-ovarian-syndrome
#2
Víctor Saúl Vital-Reyes, Mardia Guadalupe Lopez-Alarcón, Patricia Inda-Icaza, Concepción Márquez-Maldonado
Objective: To evaluate the frequency of some subtle metabolic alterations in a group of adolescents with obesity and polycystic ovary syndrome (PCOS). Materials and Methods: A cross-sectional, comparative study was conducted in a group of adolescents with obesity, and characterized as with or without PCOS according with the Rotterdam Consensus. Medical history, anthropometry, gynecologic pelvic ultrasound (to evaluate ovarian volumes, number of antral follicles and endometrial width), as well as serum glucose, insulin, lipoproteins, interleukin-6, tumor necrosis factor alpha, total testosterone, dehydroepiandrosterone, sexual hormones binding globulin, leptin, adiponectin and insulin-like growth factor 1, the free-androgen index, free and available testosterone, and homeostatic model assessment index were calculated...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29095027/the-two-sides-of-superior-mesenteric-artery-syndrome-treatment-conservative-or-surgical-management
#3
Elvia Johanna Osegueda de Rodríguez, Antonio Carlos Hernández-Villegas, Aurora Elizabeth Serralde-Zúñiga, Ana Luz Del Carmen Reyes-Ramírez
INTRODUCTION: Superior mesenteric artery syndrome (SMAS) is a rare condition characterized by vascular compression of the duodenum. There is controversy regarding the optimal treatment. CASE REPORT: In case 1, we describe the case of a 21-year-old woman (body mass index -BMI- 16.9 kg/m2) with high-level obstructive symptoms three months prior, with computed tomography scan (TC) showing a superior mesenteric artery aorta angle (SMAA) of 13º and compression of the third portion of the duodenum (D3), for this reason a nasojejunal tube was placed for enteral feeding...
July 28, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29095010/-metabolic-syndrome-and-visceral-fat-in-women-with-cardiovascular-risk-factor
#4
Anxela Soto Rodríguez, José Luis García Soidán, Mª Jesús Arias Gómez, Raquel Leirós Rodríguez, Alberto Del Álamo Alonso, Mª Reyes Pérez Fernández
INTRODUCTION: Cardiovascular diseases are the leading cause of death in women after menopause, since after this stage there are profound metabolic and hormonal changes which favor the development of metabolic syndrome. An increase in the percentage of visceral fat may be related to the onset of this syndrome. OBJECTIVE: To establish the relationship between visceral fat and parameters of the metabolic syndrome and to determine the optimal cut-off point for the variables related to obesity in women with a cardiovascular risk factor...
July 28, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29093093/glycan-shield-and-fusion-activation-of-a-deltacoronavirus-spike-glycoprotein-fine-tuned-for-enteric-infections
#5
Xiaoli Xiong, M Alejandra Tortorici, Joost Snijder, Craig Yoshioka, Alexandra C Walls, Wentao Li, Andrew T McGuire, Félix A Rey, Berend-Jan Bosch, David Veesler
Coronaviruses recently emerged as major human pathogens causing outbreaks of severe acute respiratory syndrome and Middle-East respiratory syndrome. They utilize the spike (S) glycoprotein anchored in the viral envelope to mediate host attachment and fusion of the viral and cellular membranes to initiate infection. The S protein is a major determinant of the zoonotic potential of coronaviruses and is also the main target of the host humoral immune response. We report here the 3.5 Å resolution cryo-electron microscopy structure of the S glycoprotein trimer from the pathogenic porcine deltacoronavirus (PDCoV), which belongs to the recently identified delta genus...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29062711/strongyloides-hyperinfection-syndrome-causing-fatal-meningitis-and-septicemia-by-citrobacter-koseri
#6
Felix Reyes, Navneet Singh, Nigar Anjuman-Khurram, Jihae Lee, Lillian Chow
Citrobacter koseri is a gram-negative bacillius that belongs to the Enterobacteriaceae family. It is an uncommon pathogen that typically causes meningitis and brain abscesses in children, however central nervous system (CNS) infections are rarely found in adults. We present a case of C. koseri meningitis in an immunocompetent adult secondary to intestinal micro-perforation caused by Strongyloides A 76-year-old man admitted for asthma exacerbation developed septic shock. A lumbar puncture revealed bacterial meningitis...
2017: IDCases
https://www.readbyqxmd.com/read/29043689/-mesenteric-edema-as-a-prenatal-ultrasound-sign-of-poor-prognosis-in-gastroschisis
#7
M Dore Reyes, P Triana Junco, J L Encinas Hernández, E Alvarado Antolín, J L Bartha Rasero, V Núñez Cerezo, M Romo Muñoz, M Gómez Cervantes, A Sánchez Galán, L Martínez Martínez, M López Santamaría
INTRODUCTION/AIM OF THE STUDY: Gastroschisis is a congenital malformation with an easy and early prenatal diagnosis, however, it has a variable post-natal outcome. Our aim was to determine if certain ultrasound markers or early delivery were related with a worse postnatal outcome. PATIENTS AND METHODS: Retrospective study of a cohort of patients with gastroschisis diagnosed between 2005-2014, with emphasis on prenatal ultrasounds, gestational age at delivery and post-natal outcome...
July 20, 2017: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/29036836/a-panel-of-slow-channel-congenital-myasthenic-syndrome-mice-reveals-a-unique-locomotor-behavioral-signature
#8
José G Grajales-Reyes, Aurian García-González, José C María-Ríos, Gary E Grajales-Reyes, Manuel Delgado-Vélez, Carlos A Báez-Pagán, Orestes Quesada, Christopher M Gómez, José A Lasalde-Dominicci
Muscle nicotinic acetylcholine receptor (nAChR) mutations can lead to altered channel kinetics and neuromuscular junction degeneration, a neurodegenerative disorder collectively known as slow-channel congenital myasthenic syndrome (SCCMS). A multivariate analysis using running wheels was used to generate activity profiles for a variety of SCCMS models, uncovering unique locomotor patterns for the different nAChR mutants. Particularly, the αL251T and ɛL269F mutations exhibit decreased event distance, duration, and velocity over a period of 24 hours...
October 13, 2017: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/29023232/early-onset-obesity-and-risk-of-metabolic-syndrome-among-chilean-adolescents
#9
Lorena Sonia Pacheco, Estela Blanco, Raquel Burrows, Marcela Reyes, Betsy Lozoff, Sheila Gahagan
INTRODUCTION: Obesity and metabolic syndrome (MetS) indicators have increased globally among the pediatric population. MetS indicators in the young elevate their risk of cardiovascular disease and metabolic disorders later in life. This study examined early onset obesity as a risk factor for MetS risk in adolescence. METHODS: A cohort of Chilean participants (N = 673) followed from infancy was assessed at age 5 years and in adolescence (mean age, 16.8 y). Adiposity was measured at both time points; blood pressure and fasting blood samples were assessed in adolescence only...
October 12, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29020983/cxcr2-inhibition-a-novel-approach-to-treating-coronary-heart-disease-cicada-study-protocol-for-a-randomised-controlled-trial
#10
Jubin P Joseph, Eliana Reyes, Josephine Guzman, Jim O'Doherty, Hannah McConkey, Satpal Arri, Rahul Kakkar, Nicholas Beckley, Abdel Douiri, Sally F Barrington, Simon R Redwood, Albert Ferro
BACKGROUND: There is emerging evidence of the central role of neutrophils in both atherosclerotic plaque formation and rupture. Patients with lower neutrophil counts following acute coronary syndromes tend to have a greater coronary flow reserve, which is a strong predictor of long-term cardiovascular health. But so far, no data are available regarding the impact of neutrophil inhibition on cardiovascular clinical or surrogate endpoints. Therefore, the aim of this study is to investigate the effects of AZD5069, a cysteine-X-cysteine chemokine receptor 2 (CXCR2) inhibitor, on coronary flow reserve and coronary structure and function in patients with coronary artery disease...
October 11, 2017: Trials
https://www.readbyqxmd.com/read/29017982/clinical-presentation-diagnosis-and-surgical-treatment-of-spontaneous-cervical-intradural-disc-herniations-a-review-of-the-literature
#11
REVIEW
Arunprasad Gunasekaran, Nova Kristine M de Los Reyes, Jerry Walters, Noojan Kazemi
OBJECTIVE: Spontaneous cervical intradural disc herniation (IDH) is a rare occurrence with limited and disparate information available regarding its presentation, diagnosis, and treatment. However, its accurate detection is vital for planning surgical treatment. In this review of the literature, we collected data from all cervical intradural disc herniations described to date. Particular attention is paid to diagnostic findings, surgical approach and causation for cervical IDH, especially at the cervicothoracic junction...
October 7, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28991697/zika-virus-disease-associated-guillain-barr%C3%A3-syndrome-barranquilla-colombia-2015-2016
#12
Jorge L Salinas, Diana M Walteros, Ashley Styczynski, Flavio Garzón, Hernán Quijada, Elsa Bravo, Pablo Chaparro, Javier Madero, Jorge Acosta-Reyes, Jeremy Ledermann, Zuleima Arteta, Erin Borland, Paul Burns, Maritza Gonzalez, Ann M Powers, Marcela Mercado, Alma Solano, James J Sejvar, Martha L Ospina
BACKGROUND: An outbreak of Guillain-Barré syndrome (GBS), a disorder characterized by acute, symmetric limb weakness with decreased or absent deep-tendon reflexes, was reported in Barranquilla, Colombia, after the introduction of Zika virus in 2015. We reviewed clinical data for GBS cases in Barranquilla and performed a case-control investigation to assess the association of suspect and probable Zika virus disease with GBS. METHODS: We used the Brighton Collaboration Criteria to confirm reported GBS patients in Barranquilla during October 2015-April 2016...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28984599/sleep-apnea-cognitive-profile-and%C3%A2-vascular-changes-an-intriguing-relationship
#13
Laura Buratti, Giovanna Viticchi, Sara Baldinelli, Lorenzo Falsetti, Simona Luzzi, Alessandra Pulcini, Cristina Petrelli, Leandro Provinciali, Mauro Silvestrini
BACKGROUND: Sleep breathing disorders can affect cognitive performances through complex brain anatomical and functional changes. OBJECTIVE: Our aim was to evaluate the correlations between cognitive performances and obstructive sleep apnea syndrome (OSAS), as well as the possible influence of vascular factors. METHODS: Thirty-four non-demented OSAS patients and 34 controls were submitted to a neuropsychological evaluation and to a vascular screening including the study of cerebrovascular reactivity by means of the breath-holding index (BHI) calculation...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28981517/a-recombinant-o-polysaccharide-protein-conjugate-approach-to-develop-highly-specific-monoclonal-antibodies-to-shiga-toxin-producing-escherichia-coli-o157-and-o145-serogroups
#14
Daniela S Castillo, Diego A Rey Serantes, Luciano J Melli, Andrés E Ciocchini, Juan E Ugalde, Diego J Comerci, Alejandro Cassola
Shiga toxin-producing Escherichia coli (STEC) is the major etiologic agent of hemolytic-uremic syndrome (HUS). The high rate of HUS emphasizes the urgency for the implementation of primary prevention strategies to reduce its public health impact. Argentina shows the highest rate of HUS worldwide, being E. coli O157 the predominant STEC-associated HUS serogroup (>70%), followed by E. coli O145 (>9%). To specifically detect these serogroups we aimed at developing highly specific monoclonal antibodies (mAbs) against the O-polysaccharide (O-PS) section of the lipopolysaccharide (LPS) of the dominant STEC-associated HUS serogroups in Argentina...
2017: PloS One
https://www.readbyqxmd.com/read/28975230/ocular-histopathologic-features-of-congenital-zika-syndrome
#15
Maria P Fernandez, Edgar Parra Saad, Martha Ospina Martinez, Sheryl Corchuelo, Marcela Mercado Reyes, Maria Jose Herrera, Miguel Parra Saavedra, Angelica Rico, Angela M Fernandez, Richard K Lee, Camila V Ventura, Audina M Berrocal, Sander R Dubovy
Importance: Congenital Zika syndrome (CZS) is known to be associated with severe malformations in newborns. Although microcephaly is the hallmark of this disease, the ocular findings are important given the severe visual impairment that has been observed in these patients. Regardless of the increased number of CZS cases reported, to date, no studies have described the ocular histopathologic findings of this entity. Objectives: To evaluate the presence of Zika virus (ZIKV) antigens and describe the associated ocular histopathologic features of 4 cases of CZS...
November 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28951142/cognitive-deficit-in-patients-with-paranoid-schizophrenia-its-clinical-and-laboratory-correlates
#16
Mariia Dorofeikova, Nikolay Neznanov, Nataliia Petrova
The aim of this study was to search for correlates of cognitive impairment in patients with paranoid schizophrenia among clinical, demographic, anamnestic and biochemical markers (NSE, S100B protein, BDNF, hs-CRP). Patients with paranoid schizophrenia (n=125) were examined using the Brief Assessment of Cognitive Function in Schizophrenia, the Rey-Osterrieth Complex Figure task, and a number of clinical scales including the Positive and Negative Syndrome Scale. The majority of patients demonstrated cognitive impairment...
September 20, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28946813/nationwide-french-study-of-ret-variants-detected-from-2003-to-2013-suggests-a-possible-influence-of-polymorphisms-as-modifiers
#17
Maylis Lebeault, Stéphane Pinson, Marine Guillaud-Bataille, Anne-Paule Gimenez-Roqueplo, Alain Carrie, Véronique Barbu, Pascal Pigny, Stéphane Bezieau, Jean-Marc Rey, Chantal Delvincourt, Sophie Giraud, Charlotte Veyrat-Durebex, Patrick Saulnier, Nathalie Bouzamondo, Marie Chabbert, Julien Blin, Amira Mohamed, Pauline Romanet, Francoise Borson-Chazot, Vincent Rohmer, Anne Barlier, Delphine Mirebeau-Prunier
BACKGROUND: The presence of single nucleotide polymorphisms (SNPs) in the REarranged during Transfection (RET) gene has been investigated with regard to their potential role in the development or progression of medullary thyroid cancer or pheochromocytomas (PHEO) in patients with the multiple endocrine neoplasia type 2 (MEN2) syndrome. The aim of this study was to evaluate the spectrum of RET variants in France between 2003 and 2013, and to evaluate the impact of SNPs on the MEN2 A phenotype...
November 3, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28945927/co-ingestion-of-aspirin-and-acetaminophen-promoting-fulminant-liver-failure-a-critical-review-of-reye-syndrome-in-the-current-perspective-at-the-dawn-of-the-21-st-century
#18
REVIEW
Deepak Dinakaran, Consolato Sergi
In the pediatric population, there is some evidence of possible interaction, synergism, and co-toxicity of aspirin and acetaminophen. The toxicity of salicylates such as aspirin in this population is well known and documented, specifically in the form of Reye syndrome. The possible toxic synergism with aspirin and acetaminophen, however, is not previously described; though case reports suggest such co-toxicities with low levels of aspirin and other compounds can exist. In vitro studies into mechanistic processes of salicylate toxicity propose that there are a bi-directional link and potentiation with glutathione (GSH) depletion and salicylate toxicity...
September 25, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28922055/nance-horan-syndrome-in-females-due-to-a-balanced-x-1-translocation-that-disrupts-the-nhs-gene-familial-case-report-and-review-of-the-literature
#19
Laura Gómez-Laguna, Alejandro Martínez-Herrera, Alejandra Del Pilar Reyes-de la Rosa, Constanza García-Delgado, Karem Nieto-Martínez, Fernando Fernández-Ramírez, Tania Yanet Valderrama-Atayupanqui, Ariadna Berenice Morales-Jiménez, Judith Villa-Morales, Susana Kofman, Alicia Cervantes, Verónica Fabiola Morán-Barroso
The Nance-Horan syndrome is an X-linked disorder characterized by congenital cataract, facial features, microcornea, microphthalmia, and dental anomalies; most of the cases are due to NHS gene mutations on Xp22.13. Heterozygous carrier females generally present less severe features, and up to 30% of the affected males have intellectual disability. We describe two patients, mother and daughter, manifesting Nance-Horan syndrome. The cytogenetic and molecular analyses demonstrated a 46,X,t(X;1)(p22.13;q22) karyotype in each of them...
September 18, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28919129/dissecting-the-catatonia-phenotype-in-psychotic-and-mood-disorders-on-the-basis-of-familial-genetic-factors
#20
Victor Peralta, Lourdes Fañanás, Migdyrai Martín-Reyes, Manuel J Cuesta
BACKGROUND: This study examines the familial aggregation (familiality) of different phenotypic definitions of catatonia in a sample of multiplex families with psychotic and mood disorders. METHODS: Participants were probands with a lifetime diagnosis of a DSM-IV functional psychotic disorder, their parents and at least one first-degree relative with a psychotic disorder. The study sample included 441 families comprising 2703 subjects, of whom 1094 were affected and 1609 unaffected...
September 14, 2017: Schizophrenia Research
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