keyword
MENU ▼
Read by QxMD icon Read
search

thymoquinone

keyword
https://www.readbyqxmd.com/read/28810534/thymoquinone-prevents-endoplasmic-reticulum-stress-and-mitochondria-induced-apoptosis-in-a-rat-model-of-partial-hepatic-warm-ischemia-reperfusion
#1
Ahlem Bouhlel, Ben Mosbah, Hadj Abdallah, Catherine Ribault, Roselyne Viel, Saber Mannaï, Anne Corlu, Ben Abdennebi
This study was undertaken to evaluate the protective effect of thymoquinone (TQ), the bioactive compound of Nigella sativa seeds, against warm ischemia-reperfusion (I/R) injury in liver. Rats were given an oral administration of a vehicle solution (sham group) or TQ at the appropriate dose (10, 20, 30 and 40mg/kg) for ten days consecutively. Following, they were subjected to 60min of partial hepatic ischemia followed by 24h of reperfusion. .Transaminase activities, histopathological changes, TNFα and antioxidant parameters were evaluated...
August 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28795592/semi-synthetic-thymoquinone-analogs-new-prototypes-as-potential-antihyperlipidemics-in-irradiated-rats
#2
Nashwa H Zaher, Engy R Rashed, Mona A El-Ghazaly
AIM: Thymoquinone (TQ), has been reported to possess strong antihyperlipidemic properties. However, a variety of serious side effects has been reported for TQ. The present study aimed to evaluate the potential antihyperlipidemic activity of newly synthesized TQ analogs. METHODS & RESULTS: first, novel TQ derivatives were studied against radiation-induced dyslipidemia in male rats. Second, the most promising sulfur derivatives (4-7), were further tested to elucidate their possible mechanism(s) of actions...
August 10, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28795522/assessment-of-carvacrol-for-control-of-avian-aspergillosis-in-intratracheally-challenged-chickens-in-comparison-to-voriconazole-with-a-reference-on-economic-impact
#3
Y H Tartor, F A M Hassan
AIM: This study was designed to investigate the efficacy of essential oils (EOs) as an alternative prophylaxis and treatment for avian aspergillosis. METHODS AND RESULTS: The in vitro susceptibility of A. fumigatus strains to antifungal drugs and carvacrol, thymol, eugenol, thymoquinone and cinnamon was determined using the macro-diffusion and microdilution methods. Carvacrol has antifungal activity in comparison to voriconazole (VCZ) (MIC 0.5, 0.25μg/ml, respectively)...
August 9, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28783890/reduction-of-side-effects-of-hyperbaric-oxygen-therapy-with-thymoquinone-treatment-in-rats
#4
Ali Erdal Gunes, Orhan Gozeneli, Muhammed Emin Guldur
INTRODUCTION: Hyperbaric oxygen (HBO₂) treatment results in elevated production of reactive oxygen species (ROS) that leads to cellular damage. Thymoquinone (TQ) is reported to have anti-inflammatory and antimicrobial activity and may suppress the generation of free radicals. The goal of this study is reduction of side effects of hyperbaric oxygen therapy with thymoquinone treatment. METHODS: 30 female Sprague-Dawley rats were randomly assigned to one of three groups (n = 10 per group)...
July 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28752025/biased-activity-of-soluble-guanylyl-cyclase-the-janus-face-of-thymoquinone
#5
REVIEW
Charlotte Detremmerie, Paul M Vanhoutte, Susan Leung
The natural compound thymoquinone, extracted from Nigella sativa (black cumin), is widely used in humans for its anti-oxidative properties. Thymoquinone is known for its acute endothelium-independent vasodilator effects in isolated rat aortae and pulmonary arteries, depending in part on activation of adenosine triphosphate-sensitive potassium channels and inhibition of voltage-dependent calcium channels. The compound also improves endothelial dysfunction in mesenteric arteries of ageing rodents and in aortae of rabbits treated with pyrogallol, by inhibiting oxidative stress...
July 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28751051/new-polylactic-acid-cellulose-acetate-based-antimicrobial-interactive-single-dose-nanofibrous-wound-dressing-mats
#6
Salma F Gomaa, Tarek M Madkour, Saad Moghannem, Ibrahim M El-Sherbiny
New single dose interactive extracellular matrix (ECM) mimicking nanofibrous wound dressings based on polylactic acid (PLA) and cellulose acetate (CA) were developed, characterized and investigated for wound treatment. The antimicrobial agent, thymoquinone (TQ) was selected and incorporated into the scaffolds for preventing common clinical infections, and to accelerate the rate of wound closure and re-epithelialization. The newly fabricated TQ-loaded PLA/CA wound dressings offered many advantages such as mimicking the ECM via the 3D nanofibrous structure, and promoted the cell proliferation due to the hydrophilicity and bioactivity of CA...
July 24, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28734741/beneficial-effects-of-tqrf-and-tq-nano-and-conventional-emulsions-on-memory-deficit-lipid-peroxidation-total-antioxidant-status-antioxidants-genes-expression-and-soluble-a%C3%AE-levels-in-high-fat-cholesterol-diet-induced-rats
#7
Norsharina Ismail, Maznah Ismail, Nur Hanisah Azmi, Muhammad Firdaus Abu Bakar, Zhang Yida, Johnson Stanslas, Dahiru Sani, Hamidon Basri, Maizaton Atmadini Abdullah
The study determined the effect of thymoquinone rich fraction (TQRF) and thymoquinone (TQ) in the forms of nano- and conventional emulsions on learning and memory, lipid peroxidation, total antioxidant status, antioxidants genes expression and soluble β-amyloid (Aβ) levels in rats fed with a high fat-cholesterol diet (HFCD). The TQRF was extracted from Nigella sativa seeds using a supercritical fluid extraction system and prepared into nanoemulsion, which later named as TQRF nanoemulsion (TQRFNE). Meanwhile, TQ was acquired commercially and prepared into thymoquinone nanoemulsion (TQNE)...
July 20, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28708300/radioprotective-effect-of-thymoquinone-on-salivary-gland-of-rats-exposed-to-total-cranial-irradiation
#8
Mehmet Akyuz, Seyithan Taysi, Elif Baysal, Elif Demir, Hilal Alkis, Muslum Akan, Habip Binici, Zeynel Abidin Karatas
BACKGROUND: The purpose of this study was to investigate the radioprotective effects of thymoquinone against radiation-induced damage in the salivary glands of rats exposed to total cranial gamma irradiation. METHODS: Thirty-two Sprague-Dawley rats were divided into 4 groups to test the radioprotective effectiveness of thymoquinone by intraperitoneal injection. An appropriate control group was also studied. Biochemical parameters in liver tissue of rats were determined by spectrophotometer...
July 14, 2017: Head & Neck
https://www.readbyqxmd.com/read/28707601/potential-role-of-natural-compounds-as-anti-angiogenic-agents-in-cancer
#9
Muthu K Shanmugam, Sudha Warrier, Alan Prem Kumar, Gautam Sethi, Frank Arfuso
BACKGROUND: Neovascularization, also known as angiogenesis, is the process of capillary sprouting from pre-existing blood vessels. This physiological process is a hallmark event in normal embryonic development as blood vessels generally supply both oxygen and nutrients to the cells of the body. Any disruption in this process can lead to the development of various chronic diseases, including cancer. In cancer, aberrant angiogenesis plays a prominent role in maintaining sustained tumor growth to malignant phenotypes and promoting metastasis...
July 12, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28701649/deodorizing-substance-in-black-cumin-nigella-sativa-l-seed-oil
#10
Toru Nakasugi, Takushi Murakawa, Koji Shibuya, Masanori Morimoto
A deodorizing substance in black cumin (Nigella sativa L.), a spice for curry and vegetable foods in Southwest Asia, was examined. The essential oil prepared from the seeds of this plant exhibited strong deodorizing activity against methyl mercaptan, which is a main factor in oral malodor. After purification with silica gel column chromatography, the active substance in black cumin seed oil was identified as thymoquinone. This monoterpenic quinone functions as the main deodorizing substance in this oil against methyl mercaptan...
August 1, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28698449/in-vitro-evaluation-of-the-inhibitory-activity-of-thymoquinone-in-combatting-candida-albicans-in-denture-stomatitis-prevention
#11
Ahmad M Al-Thobity, Khalifa S Al-Khalifa, Mohammed M Gad, Mohammed Al-Hariri, Aiman A Ali, Talal Alnassar
Candida albicans adhesion and proliferation on denture bases may lead to denture stomatitis, which is a common and recurrent problem in denture wearers. The goal of this study was to assess the inhibitory effect of thymoquinone incorporated in the polymethyl methacrylate denture base material against Candida albicans. Eighty acrylic resin specimens were fabricated and divided into eight groups (n = 10) according to thymoquinone concentrations of 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, and 5% of acrylic powder. Two methods were used to evaluate the effect of thymoquinone on Candida albicans: the slide count and the serial dilution test...
July 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28693287/effect-of-thymoquinone-on-head-and-neck-squamous-cell-carcinoma-cells-in-vitro-synergism-with-radiation
#12
Ulana Kotowski, Gregor Heiduschka, Lorenz Kadletz, Tammer Fahim, Rudolf Seemann, Rainer Schmid, Sven Schneider, Andreas Mitterbauer, Dietmar Thurnher
Thymoquinone (TQ) is the main bioactive constituent present in black seed oil (Nigella sativa); it has shown anti-inflammatory and anti-neoplastic effects in various cancer cell types. The aim of the present study was to investigate the effects of TQ on head and neck squamous cell carcinoma (HNSCC) cell lines, on its own and in combination with radiation and cisplatin, respectively. The SCC25 and CAL27 HNSCC cell lines were treated with TQ alone and in combination with cisplatin or radiation, respectively. Proliferation assays and clonogenic assays were performed...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28692636/the-effect-of-thymoquinone-on-apoptosis-of-sk-ov-3-ovarian-cancer-cell-by-regulation-of-bcl-2-and-bax
#13
Xiaoli Liu, Jinhu Dong, Wangyu Cai, Ying Pan, Ruili Li, Bing Li
OBJECTIVE: We aim to determine how cisplatin, thymoquinone (TQ), and combination regimen can affect apoptosis of cultured SK-OV-3 cells. We also want to explore the mechanism of these influences on the cells' apoptosis by Bcl-2 and Bax gene. METHOD/MATERIALS: Cell Counting Kit-8 assay was used to measure the viability of cultured ovarian cancer cells. Propidium iodide with flow cytometry was used in cell cycle analysis. Thereafter, we used fluorescein isothiocyanate-stained annexin V and propidium iodide to detect the effect of cisplatin, TQ, and combination regimen on apoptosis...
July 7, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28671634/regressions-of-breast-carcinoma-syngraft-following-treatment-with-piperine-in-combination-with-thymoquinone
#14
Wamidh H Talib
Thymoquinone (TQ) and piperine, the active ingredients in cumin (Nigella sativa) and black pepper (Piper longum), respectively, exhibit various bioactivities including anticancer effects. The aim of the present study is to investigate the antineoplastic activity of a combination of TQ and piperine against breast cancer implanted in mice. The antiproliferative effects of TQ, piperine, and a combination of both agents were tested against mouse epithelial breast cancer cell line (EMT6/P) using MTT assay. The isobolographic method was used to calculate the combination index (CI)...
July 3, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28661475/protein-kinase-a-activation-by-the-anti-cancer-drugs-abt-737-and-thymoquinone-is-caspase-3-dependent-and-correlates-with-platelet-inhibition-and-apoptosis
#15
Natalia Rukoyatkina, Elke Butt, Hariharan Subramanian, Viacheslav O Nikolaev, Igor Mindukshev, Ulrich Walter, Stepan Gambaryan, Peter M Benz
Chemotherapy-induced thrombocytopenia is a common bleeding risk in cancer patients and limits chemotherapy dose and frequency. Recent data from mouse and human platelets revealed that activation of protein kinase A/G (PKA/PKG) not only inhibited thrombin/convulxin-induced platelet activation but also prevented the platelet pro-coagulant state. Here we investigated whether or not PKA/PKG activation could attenuate caspase-dependent apoptosis induced by the anti-cancer drugs ABT-737 (the precursor of navitoclax) and thymoquinone (TQ), thereby potentially limiting chemotherapy-induced thrombocytopenia...
June 29, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28659794/thymoquinone-as-a-potential-adjuvant-therapy-for-cancer-treatment-evidence-from-preclinical-studies
#16
REVIEW
A G M Mostofa, Md Kamal Hossain, Debasish Basak, Muhammad Shahdaat Bin Sayeed
Thymoquinone (TQ), the main bioactive component of Nigella sativa, has been found to exhibit anticancer effects in numerous preclinical studies. Due to its multitargeting nature, TQ interferes in a wide range of tumorigenic processes and counteracts carcinogenesis, malignant growth, invasion, migration, and angiogenesis. Moreover, TQ can specifically sensitize tumor cells toward conventional cancer treatments (e.g., radiotherapy, chemotherapy, and immunotherapy) and simultaneously minimize therapy-associated toxic effects in normal cells...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28647592/liposphere-mediated-topical-delivery-of-thymoquinone-in-the-treatment-of-psoriasis
#17
Anjali Jain, Venkatesh Pooladanda, Upendra Bulbake, Sindhu Doppalapudi, Towseef Amin Rafeeqi, Chandraiah Godugu, Wahid Khan
Thymoquinone (TMQ) is reported with good anti-psoriatic activity; however, the hydrophobicity, poor aqueous solubility, light and pH sensitive nature of TMQ hinder its delivery to target site. To address these delivery challenges of TMQ, lipospheres were explored. The topical use of lipospheres offers an effective mean of penetration along with stability and scalability. TMQ lipospheres of particle size below 70 nm were prepared and evaluated. These lipospheres resulted in deeper skin penetration, slow release and skin compatibility...
June 22, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28629150/role-of-nigella-sativa-and-its-constituent-thymoquinone-on-chemotherapy-induced-nephrotoxicity-evidences-from-experimental-animal-studies
#18
REVIEW
Marco Cascella, Giuseppe Palma, Antonio Barbieri, Sabrina Bimonte, Nagoth Joseph Amruthraj, Maria Rosaria Muzio, Vitale Del Vecchio, Domenica Rea, Michela Falco, Antonio Luciano, Claudio Arra, Arturo Cuomo
BACKGROUND: Most chemotherapeutic drugs are known to cause nephrotoxicity. Therefore, new strategies have been considered to prevent chemotherapy-induced nephrotoxicity. It is of note that Nigella sativa (NS), or its isolated compound Thymoquinone (TQ), has a potential role in combating chemotherapy-induced nephrotoxicity. AIM: To analyze and report the outcome of experimental animal studies on the protective effects of NS/TQ on chemotherapy-associated kidney complications...
June 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28606050/insights-into-the-targeting-potential-of-thymoquinone-for-therapeutic-intervention-against-triple-negative-breast-cancer
#19
Md Abul Barkat, Harshita Abul, Javed Ahmad, Mohammad Ahmed Khan, Sarwar Beg, Farhan Jalees Ahmad
BACKGROUND: Thymoquinone (TQ) is a bioactive phytoconstituent obtained from Nigella sativa (black seeds). It has promising potential in cancer prevention. OBJECTIVE: Previous studies have shown that TQ can modulate signaling pathways responsible for cancer progression, thus enhances the efficacy and improve safety profile of clinically used anticancer drugs. METHOD: TQ acts on cell cycle and inhibits progression from G1 to S phase by targeting various proteins (cyclin D1, cyclin E, and p27)...
June 11, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28603137/review-nigella-sativa-prophetic-medicine-a-review
#20
Hira Ijaz, Ume Ruqia Tulain, Junaid Qureshi, Zeeshan Danish, Samina Musayab, Muhammad Furqan Akhtar, Ammara Saleem, Khanzada Khanzada Khan, Muhammad Zaman, Imran Waheed, Imran Khan, Mohamed Abdel-Daim
The present report is a significant effort to explore detail description of N. Sativa, its pharmacognostic characteristics, morphological characteristics, and mechanism of actions, doses and medicinal uses. Nigella sativa (N. Sativa) is greatest form of healing medicine. It is also known as Prophetic Medicine as its use has been mentioned in Prophetic Hadit, as natural remedy for all the diseases except death. It is recommended on daily basis in Tibb-e-Nabwi (Prophetic Medicine). Hazrat Abu Hurairah States ''I have heard from Rasool Allah (PBUH) that there is cure for every disease in black seeds except death and black seeds are shooneeze''...
January 2017: Pakistan Journal of Pharmaceutical Sciences
keyword
keyword
83742
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"