keyword
MENU ▼
Read by QxMD icon Read
search

thymoquinone

keyword
https://www.readbyqxmd.com/read/29303137/comparison-of-icodextrin-with-thymoquinone-a-new-hope-for-postoperative-adhesions
#1
Ö Yilmaz, R Kiziltan, S Çelik, S Yildirm, H H Alp, A Aras, Ç Kotan
OBJECTIVE: The purpose of this study was to compare the effects of thymoquinone and icodextrin in rats within the framework of an experimental adhesion model. MATERIALS AND METHODS: Rats were separated into three groups: (1) a control group consisting of rats that had 2 ml of isotonic solution administered intraperitoneally, (2) an ICO group administered with 2 ml of 4% icodextrin, and (3) a TQ group administered thymoquinone (10 mg/kg), all following cecal abrasion...
November 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29302711/oral-nigella-sativa-oil-and-thymoquinone-administration-ameliorates-the-effect-of-long-term-cisplatin-treatment-on-the-enzymes-of-carbohydrate-metabolism-brush-border-membrane-and-antioxidant-defense-in-rat-intestine
#2
Faaiza Shahid, Zeba Farooqui, Aijaz Ahmed Khan, Farah Khan
We have previously shown that oral administration of Nigella sativa oil (NSO) ameliorates the deleterious gastrointestinal effects of cisplatin (CP), administered as a single dose. Since a typical clinical CP dosing regimen involves multiple cycles of CP administration in lower doses, in the present study we investigate the protective efficacy of NSO and its major bioactive constituent, thymoquinone (TQ), against multiple-dose CP treatment-induced deleterious biochemical and histological changes in rat intestine...
January 4, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29299433/thymoquinone-restores-liver-fibrosis-and-improves-oxidative-stress-status-in-a-lipopolysaccharide-induced-inflammation-model-in-rats
#3
Fereshteh Asgharzadeh, Rahimeh Bargi, Farimah Beheshti, Mahmoud Hosseini, Mehdi Farzadnia, Majid Khazaei
Objective: Liver fibrosis is the primary sign of chronic liver injury induced by various causes. Thymoquinone (TQ) is the major ingredient of Nigella sativa with several beneficial effects on the body. In the present study, we aimed to investigate the effect of TQ on liver fibrosis in a lipopolysaccharide (LPS)-induced inflammation in male rats. Materials and methods: Fifty male Wistar rats were randomly divided into five groups (n=10 in each group) as follow: (1) control; (2) LPS (1 mg/kg/day; i...
November 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29283096/the-role-of-topical-thymoquinone-in-the-treatment-of-acute-otitis-externa-an-experimental-study-in-rats
#4
Hasan Demirel, Cengiz Arlı, Tümay Özgür, Melek İnci, Recep Dokuyucu
OBJECTIVE: The aim of this experimental study was to compare the dose-related effect of topical thymoquinone (TQ) with other topical agents used in the management of acute otitis externa (AOE) in a rat model. MATERIALS AND METHODS: Forty-eight male Wistar albino rats were divided into six groups each with eight rats per group. Group I was the control group with no external otitis, whereas external otitis were created in the other five groups (study groups). Dexamethasone, 0...
December 14, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29277983/thymoquinone-can-improve-neuronal-survival-and-promote-neurogenesis-in-rat-hippocampal-neurons
#5
Merve Beker, Tuğçe Dallı, Birsen Elibol
SCOPE: Thymoquinone (TQ) has been used as a potential therapeutic for diseases such as cancer, and diabetes. Herein, we aimed to investigate the effect of TQ on behavioral and molecular parameters in healthy rat hippocampus. METHODS: TQ (20 mg/kg/day) was administered intragastrically for 15 days to adult rats. After the behavioral tests, the hippocampal tissues were investigated in histological and molecular level. RESULTS: In both DG and CA1, TQ significantly increased the number of hippocampal neurons...
December 26, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29234307/thymoquinone-inhibits-virulence-related-traits-of-cronobacter-sakazakii-atcc-29544-and-has-anti-biofilm-formation-potential
#6
Chao Shi, Chunhong Yan, Yue Sui, Yi Sun, Du Guo, Yifei Chen, Tong Jin, Xiaoli Peng, Linlin Ma, Xiaodong Xia
The aim of this study was to determine whether thymoquinone, the principal active ingredient in the volatile oil of Nigella sativa seeds, could suppress certain virulence traits of Cronobacter sakazakii ATCC 29544 which contribute to infection. Sub-inhibitory concentrations of thymoquinone significantly decreased motility, quorum sensing, and endotoxin production of C. sakazakii ATCC 29544 and biofilm formation of C. sakazakii 7-17. Thymoquinone substantially reduced the adhesion and invasion of C. sakazakii ATCC 29544 to HT-29 cells and decreased the number of intracellular bacterial cells within the RAW 264...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29230814/nigella-sativa-l-as-an-alternative-antibiotic-feed-supplement-and-effect-on-growth-performance-in-weanling-pigs
#7
Branko T Petrujkić, Ross C Beier, Haiqi He, Kenneth J Genovese, Christina L Swaggerty, Michael E Hume, Tawni L Crippen, Roger B Harvey, Robin C Anderson, David J Nisbet
BACKGROUND: Nigella sativa L. (NS) is a plant containing bioactive constituents like thymoquinone. Extracts of NS improve performance and reduce enteropathogen colonization in poultry and small ruminants but studies with swine are lacking. In two different studies oral administration of NS extracts at doses equivalent to 0, 1.5 and 4.5 g extract kg-1 diet was assessed on piglet performance and intestinal carriage of wildtype Escherichia coli and Campylobacter, and Salmonella Typhimurium...
December 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29229873/thymoquinone-induces-cytotoxicity-and-reprogramming-of-emt-in-gastric-cancer-cells-by-targeting-pi3k-akt-mtor-pathway
#8
Li-Min Feng, Xue-Feng Wang, Qing-Xian Huang
Gastric cancer is one of the lethal causes of cancer-related deaths worldwide. The incidence and mortality rates of this disease is comparatively higher in China. In the current study, we evaluated the anticancer effects of Thymoquinone (TQ) against gastric cancer cells (MGC80-3 and SGC-7901) and normal noncancerous GES-1 cells and attempted to investigate the underlying mechanism. Our results indicated that TQ exhibited significant growth inhibitory effects on gastric cancer cells (MGC80-3 and SGC-7901). However, lower cytotoxicity was observed against normal GES-1 cells...
December 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/29223556/therapeutic-effects-of-thymoquinone-for-the-treatment-of-central-nervous-system-tumors-a-review
#9
REVIEW
Tahereh Farkhondeh, Saeed Samarghandian, Soroush Hozeifi, Mohsen Azimi-Nezhad
BACKGROUND: The aim of this study is to review the effects of thymoquinone (TQ) against central nervous systems (CNS) tumors. METHODS: In this study, we extensively reviewed all articles on the terms of N. sativa, TQ, CNS tumors, and different disorders in PubMed, Science Direct, Scopus, and Google Scholar databases between the years 1990 and 2017. RESULTS: The present study found that TQ has many therapeutic effects due to its antioxidant, anti-inflammatory, and anti-proliferative activities...
December 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29223554/oral-administration-of-nigella-sativa-oil-and-thymoquinone-attenuates-long-term-cisplatin-treatment-induced-toxicity-and-oxidative-damage-in-rat-kidney
#10
Zeba Farooqui, Faaiza Shahid, Aijaz Ahmed Khan, Farah Khan
Cisplatin (CP) is an effective anti-cancer drug which causes remarkable toxicity to the kidney, particularly to proximal tubules, by generating reactive oxygen species. Nigella sativa (NS), commonly known as "black cumin" reduces the progression of various kidney disorders. Thymoquinone (TQ), the major bioactive constituent of NS seeds, has been credited for various pharmacological effects of NS. Since, a typical clinical CP dosing regimen involves CP administration in multiple cycles over a long time duration, hence the present study aimed to evaluate the renoprotective efficacy of NS oil and TQ against multiple dose CP treatment induced deleterious biochemical and histological alterations in rat kidney...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29207526/thymoquinone-inhibits-the-migration-and-invasive-characteristics-of-cervical-cancer-cells-siha-and-caski-in-vitro-by-targeting-epithelial-to-mesenchymal-transition-associated-transcription-factors-twist1-and-zeb1
#11
Jun Li, Md Asaduzzaman Khan, Chunli Wei, Jingliang Cheng, Hanchun Chen, Lisha Yang, Iqra Ijaz, Junjiang Fu
Cervical cancer is one of the most common gynecological malignant tumors worldwide, for which chemotherapeutic strategies are limited due to their non-specific cytotoxicity and drug resistance. The natural product thymoquinone (TQ) has been reported to target a vast number of signaling pathways in carcinogenesis in different cancers, and hence is regarded as a promising anticancer molecule. Inhibition of epithelial to mesenchymal transition (EMT) regulators is an important approach in anticancer research. In this study, TQ was used to treat the cervical cancer cell lines SiHa and CaSki to investigate its effects on EMT-regulatory proteins and cancer metastasis...
December 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29204176/thymoquinone-protects-the-rat-kidneys-against-renal-fibrosis
#12
Rahimeh Bargi, Fereshteh Asgharzadeh, Farimah Beheshti, Mahmoud Hosseini, Mehdi Farzadnia, Majid Khazaei
Thymoquinone (TQ) is the main active ingredient of Nigella sativa seeds with various pharmacological effects. The aim of this study was to investigate the effect of TQ on renal fibrosis and permeability and oxidative stress status in lipopolysaccharide (LPS)-induced inflammation in male rats. Eighty male Wistar rats were divided into 5 groups as follow: control (received normal saline), LPS (1 mg/kg/day), and LPS+TQ (by doses of 2, 5 and 10 mg/kg/day). After three weeks, the biochemical parameters such as blood urea nitrogen (BUN) and creatinine in serum samples, oxidative stress markers including malondialdehyde (MDA), total thiol groups, superoxide dismutase (SOD) and catalase (CAT) activities in renal tissue homogenate and renal permeability (evaluated by Evan's blue dye method) were measured and renal fibrosis was evaluated, histologically using Masson's trichrome staining...
December 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29198130/the-protective-effect-of-thymoquinone-over-olanzapine-induced-side-effects-in-liver-and-metabolic-side-effects
#13
S Bilgic, D Tastemir Korkmaz, S Azirak, A N Guvenc, N Kocaman, M K Ozer
OBJECTIVES: The aim of the study was to investigate the possible protective qualities of thymoquinone (TQ) against the side-effects of olanzapine (OLZ) in an experimental model in rat liver with histologic and biochemical assessments. METHODS: Experimental procedures were performed on 35 female Sprague Dawley rats. Rats were randomly divided into five groups as: group 1: control; group 2: OLZ; group 3: OLZ+TQ-1; group 4: OLZ+TQ-2; and group 5: OLZ+TQ-3. RESULTS: The results showed that a 2‑week administration of OLZ (4 mg/kg, once a day for the first week, 8 mg/kg once a day for the second week, p...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29197940/thymoquinone-augments-cisplatin-induced-apoptosis-on-esophageal-carcinoma-through-mitigating-the-activation-of-jak2-stat3-pathway
#14
Xue Hu, Jingjing Ma, Vikash Vikash, Jiao Li, Dandan Wu, Ya Liu, Jixiang Zhang, Weiguo Dong
BACKGROUND: Thymoquinone (TQ) is the major constituent of Nigella sativa seed and has shown biological activity in various human carcinomas. However, few studies have reported its effect on esophageal carcinoma (EC). AIMS: To explore the chemosensitive effect and mechanism of TQ in augmentation of cisplatin (DDP)-induced apoptosis of EC, both in vitro and in vivo. METHODS: The viability and apoptosis of esophageal carcinoma cells were detected by the Cell Counting Kit-8 assay, flow cytometry, and Hoechst 33258 staining...
December 2, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29189187/thymoquinone-tq-a-potential-therapeutic-molecule-role-of-colloidal-carriers-in-its-effective-delivery
#15
Poonam Negi, Charul Rathore, Gajanand Sharma, Bhupinder Singh Bhoop, Om Prakash Katare
From the past few decades, remarkable awareness has been laid on the use of herbal medicines in pharmaceutical research. Thymoquinone (TQ), the main chemical constituent of Nigella sativa (NS) plant has been extensively explored and revealed an array of therapeutic benefits in different in vitro and in vivo conditions. This review provides brief outline of the diverse therapeutics actions of TQ and NS viz. anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, gastro-protective, hepato-protective, anti-microbial and anti-histaminic...
November 29, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29172688/effect-of-nanoparticle-treatment-on-expression-of-a-key-gene-involved-in-thymoquinone-biosynthetic-pathway-in-nigella-sativa-l
#16
Mir Mohammad Hassan Kahila, Amin Mahdi Najy, Mahdi Rahaie, Mohammad Mir-Derikvand
Thymoquinone is the most important secondary metabolite in black Cumin, which has several pharmaceutical applications. In this study, effect of TiO2 and SiO2 nanoparticles as new elicitors, on expression of Geranyl diphosphate synthase gene (GPPS gene), as a key gene involved in thymoquione biosynthesis pathway was investigated in two Iranian accessions. Plants were treatment in the early flowering stage and after 24 h of 50 and 100 mg/L of each nanoparticle, separately. After RNA extraction, GPPS gene expression was analysed by qRT-PCR method...
November 27, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29162539/modulation-of-diverse-oncogenic-transcription-factors-by-thymoquinone-an-essential-oil-compound-isolated-from-the-seeds-of-nigella-sativa-linn
#17
REVIEW
Muthu K Shanmugam, Frank Arfuso, Alan Prem Kumar, Lingzhi Wang, Boon Cher Goh, Kwang Seok Ahn, Anupam Bishayee, Gautam Sethi
Thymoquinone (TQ), isolated almost fifty years ago, is the main bioactive constituent of black seed essential oil extracted from the seed of Nigella sativa. TQ has been shown to have promising effects against a variety of inflammatory diseases and cancer. Cancer development is a multistep process where normal cells acquire qualities that enable the cells to proliferate continuously and migrate to distant sites in the human body. Drugs that interfere with this process are considered potential anti-cancer therapeutics, which may ultimately result in their clinical usage...
November 18, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29156767/enhancing-conventional-chemotherapy-drug-cisplatin-induced-anti-tumor-effects-on-human-gastric-cancer-cells-both-in-vitro-and-in-vivo-by-thymoquinone-targeting-pten-gene
#18
Jingjing Ma, Xue Hu, Jiao Li, Dandan Wu, Qingzhi Lan, Qian Wang, Shan Tian, Weiguo Dong
Combination chemotherapy regimen with several anti-tumor drugs is a strategy to improve outcome. Thymoquinone (TQ) has been reported to exert biological activity on various types of human cancers without obvious toxicity. However, only few studies showed the anti-tumor effects of TQ combination with cisplatin on gastric cancer (GC). Here, we showed pretreatment with 5μM TQ significantly increased the apoptotic effects induced by cisplatin on GC cell lines. Combined treatment of cisplatin with TQ represented a significantly superior tumor suppression effect than either agent alone in a xenograft tumor mouse model...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29148797/nigegladines-a-c-three-thymoquinone-dimers-from-nigella-glandulifera
#19
Jie Tian, Chao Han, Wen-Hua Guo, Yong Yin, Xiao-Bing Wang, Hong-Bin Sun, He-Quan Yao, Yong Yang, Chen Wang, Chang Liu, Ming-Hua Yang, Ling-Yi Kong
Nigegladines A-C (1-3), three thymoquinone dimers, were isolated from the seeds of Nigella glandulifera. Racemic 1 possesses a unique tricyclo[5.4.0.1(2,6)]dodecane carbon skeleton, and compounds 2 and 3 are two unusual diterpenoid alkaloids with indole cores. Their structures were determined by extensive spectroscopic analyses, and that of 1 was confirmed by single-crystal X-ray diffraction. Both (+)-1 and (-)-1 exhibited significant protective effects against hypoxia/reoxygenation-induced H9c2 myocardial cell injury...
November 17, 2017: Organic Letters
https://www.readbyqxmd.com/read/29142424/apoptotic-effect-of-nigella-sativa-on-human-lymphoma-u937-cells
#20
Belkis Atasever Arslan, Fatma Busra Isik, Hazal Gur, Fatih Ozen, Tunc Catal
Objective: Nigella sativa is from botanical Ranunculaceae family and commonly known as black seed. Apoptotic effect of N. sativa and its apoptotic signaling pathways on U937 lymphoma cells are unknown. Materials and Methods: In this study, we investigated selective cytotoxic and apoptotic effects of N. sativa extract and its apoptotic mechanisms on U937 cells. In addition, we also studied selective cytotoxic activity of thymoquinone that is the most active essential oil of N...
October 2017: Pharmacognosy Magazine
keyword
keyword
83742
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"