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https://www.readbyqxmd.com/read/29793197/association-of-low-moderate-urine-arsenic-and-qt-interval-cross-sectional-and-longitudinal-evidence-from-the-strong-heart-study
#1
Katherine A Moon, Yiyi Zhang, Eliseo Guallar, Kevin A Francesconi, Walter Goessler, Jason G Umans, Lyle G Best, Barbara V Howard, Richard B Devereux, Peter M Okin, Ana Navas-Acien
Epidemiologic studies suggest that chronic exposure to arsenic is related to cardiovascular disease (CVD), but the pathophysiological link remains uncertain. We evaluated the association of chronic low-moderate arsenic exposure and arsenic metabolism with baseline difference and annual change in ECG measures (QT interval, JT interval, PR interval, QRS duration, and QT dispersion) using linear mixed models in the Strong Heart Study main cohort (N = 1174, median age 55 years) and family study (N = 1695 diabetes-free, median age 36 years)...
May 21, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29793195/alcohol-and-drugs-use-among-drivers-injured-in-road-accidents-in-campania-italy-a-8-years-retrospective-analysis
#2
Anna Carfora, Carlo Pietro Campobasso, Paola Cassandro, Raffaella Petrella, Renata Borriello
A recent update of the Italian Road Traffic Law (RTL 41/2016), established severe penal sanctions when drivers, driving under the influence of alcohol (DUI) or drugs (DUID), are involved in road accident that results in death or injuries. A study was carried out to assess the trends of consumption of alcohol, illicit drugs or pharmaceutical among injured drivers suspected for DUI or DUID from 2009 to 2016 in the region of Campania (Italy). Confirmation toxicological analyses were performed on 780 blood samples and 1017 urine samples collected from 1797 injured drivers...
May 9, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29793163/rheological-characterisation-of-concentrated-domestic-slurry
#3
A K Thota Radhakrishnan, J B van Lier, F H L R Clemens
The much over-looked element in new sanitation, the transport systems which bridge the source and treatment facilities, is the focus of this study. The knowledge of rheological properties of concentrated domestic slurry is essential for the design of the waste collection and transport systems. To investigate these properties, samples were collected from a pilot sanitation system in the Netherlands. Two types of slurries were examined: black water (consisting of human faecal waste, urine, and flushed water from vacuum toilets) and black water with ground kitchen waste...
May 3, 2018: Water Research
https://www.readbyqxmd.com/read/29793068/prenatal-phthalate-exposure-birth-outcomes-and-dna-methylation-of-alu-and-line-1-repetitive-elements-a-pilot-study-in-china
#4
Li-Li Huang, Bin Zhou, Song-Hua Ai, Pan Yang, Ying-Jun Chen, Chong Liu, Yan-Ling Deng, Qing Lu, Xiao-Ping Miao, Wen-Qing Lu, Yi-Xin Wang, Qiang Zeng
BACKGROUND: Epigenetic mechanisms, such as altered DNA methylation, may participate in the relationship between prenatal phthalate exposure and adverse birth outcomes. OBJECTIVE: To explore the mediation effect of DNA methylation in the associations of phthalate exposure before delivery with birth outcomes in a Chinese cohort. METHODS: Eight phthalate metabolites in maternal urine before delivery and DNA methylation of Alu and long interspersed nucleotide elements (LINE-1) in cord blood were determined among 106 mother-infant pairs...
May 7, 2018: Chemosphere
https://www.readbyqxmd.com/read/29792169/use-of-synthetic-adrenocorticotropic-hormone-in-patients-with-iga-nephropathy
#5
Bhanu Prasad, Shelley Giebel, Michelle C E McCarron, Nelson Leung
BACKGROUND: Synthetic adrenocorticotropic hormone (ACTH) has been demonstrated to be effective in patients with membranous nephropathy, minimal change disease and some histological subtypes of focal segmental glomerulosclerosis. Its clinical impact in patients with IgA nephropathy is currently unclear. CASE PRESENTATION: In this report, we describe the clinical use of ACTH in patients with IgA nephropathy. Three female patients (24-44 years) with overt proteinuria received intramuscular (IM) ACTH for varying time periods (8-14 months)...
May 23, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29792032/a-tict-based-turn-on-fluorogenic-nano-probe-for-realtime-detection-of-serum-albumin-in-physiological-condition
#6
Soham Samanta, Senjuti Halder, Gopal Das
Two, cyanine based fluorescent probes L [(E)-2-(4-(diethylamino)-2-hydroxystyryl)-3-ethyl-1,1-dimethyl-1H-benzo[e]indol-3-ium iodide] and L1 [(E)-3-ethyl-1,1-dimethyl-2-(4-nitrostyryl)-1H-benzo[e]indol-3-ium iodide] have been designed and synthesized. Among these two probes; TICT (twisted intramolecular charge transfer) based probe L can preferentially self-assemble to form nanoaggregates. L displayed a selective TURN-ON fluorescence response towards HSA and BSA in ~100% aqueous PBS buffer medium which is noticeable through naked eye whereas L1 failed to sense these albumin proteins...
May 24, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29791591/searching-for-the-best-real-time-rt-pcrs-to-detect-zika-virus-infections-the-importance-of-comparing-several-protocols
#7
F M de Moraes, D L A Espósito, T M Klein, B A L da Fonseca
Clinical manifestations of Zika, dengue, and chikungunya virus infections are very similar, making it difficult to reach a diagnosis based only on clinical grounds. In addition, there is an intense cross-reactivity between antibodies directed to Zika virus and other flaviviruses, and an accurate Zika diagnosis is best achieved by real-time RT-PCR. However, some real-time RT-PCR show better performance than others. To reach the best possible Zika diagnosis, the analytic sensitivity of some probe-based real-time RT-PCR amplifying Zika virus RNA was evaluated in spiked and clinical samples...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29791502/anthropometry-based-24-h-urinary-creatinine-excretion-reference-for-chinese-children
#8
Wei Wang, Cong Du, Laixiang Lin, Wen Chen, Long Tan, Jun Shen, Elizabeth N Pearce, Yixin Zhang, Min Gao, Jianchao Bian, Xiaoming Wang, Wanqi Zhang
To establish 24-h urinary creatinine excretion reference ranges based on anthropometry in healthy Chinese children, a cross-sectional survey was conducted using twice-sampled 24-h urine and anthropometric variables. Age- and sex-specific 24-h creatinine excretion reference ranges (crude and related to individual anthropometric variables) were derived. During October 2013 and May 2014, urine samples were collected. Anthropometric variables were measured in the first survey. Data of 710 children (377 boys and 333 girls) aged 8-13 years who completed the study were analyzed...
2018: PloS One
https://www.readbyqxmd.com/read/29791315/incidence-of-early-onset-sepsis-in-infants-born-to-women-with-clinical-chorioamnionitis
#9
Tara M Randis, Madeline Murguia Rice, Leslie Myatt, Alan T N Tita, Kenneth J Leveno, Uma M Reddy, Michael W Varner, John M Thorp, Brian M Mercer, Mara J Dinsmoor, Susan M Ramin, Marshall W Carpenter, Philip Samuels, Anthony Sciscione, Jorge E Tolosa, George Saade, Yoram Sorokin
OBJECTIVE: To determine the frequency of sepsis and other adverse neonatal outcomes in women with a clinical diagnosis of chorioamnionitis. METHODS: We performed a secondary analysis of a multi-center placebo-controlled trial of vitamins C/E to prevent preeclampsia in low risk nulliparous women. Clinical chorioamnionitis was defined as either the "clinical diagnosis" of chorioamnionitis or antibiotic administration during labor because of an elevated temperature or uterine tenderness in the absence of another cause...
May 23, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29791061/antidiuretic-hormone-release-associated-with-increased-intracranial-pressure-independent-of-plasma-osmolality
#10
William J Keller, Elda Mullaj
OBJECTIVE: Introduce and evaluate a new model which explains the release of brain antidiuretic hormone (ADH) independent of plasma osmolality. METHODS: Systematic review and critical analysis of the professional literature. RESULTS: Primary electronic database searches using key terms revealed 57,432 hits. Secondary searches with application of specific inclusion and exclusion criteria and manual inspection for completeness reduced the total number of studies to fourteen (N = 14)...
May 23, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29790935/intake-and-feed-utilization-in-two-breeds-of-pregnant-beef-cows-fed-forages-with-high-fiber-concentrations
#11
M Jardstedt, A Hessle, P Nørgaard, L Frendberg, E Nadeau
Hereford and Charolais beef cows (n = 24 per breed) were used to study the effect of breed and to evaluate how late cut reed canarygrass (RC) and whole-crop oats plus urea (WCO) compared to late cut timothy (TG) with respect to feed intake and digestibility, rumination time, fecal particle size (PS) distribution, N excretion, and ruminal microbial CP production (MCP). The TG and RC were cut at flowering and WCO at hard dough stage of maturity. Cows were group-housed, six groups per breed, and fed the three diets ad libitum in three periods...
May 22, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29790809/characterization-of-in-vitro-and-in-vivo-metabolism-of-leelamine-using-liquid-chromatography-tandem-mass-spectrometry
#12
Riya Shrestha, Jung Jae Jo, DooHyun Lee, Taeho Lee, Sangkyu Lee
1. Leelamine is a diterpene compound found in the bark of pine trees and has garnered considerable interest owing to its potent anticancer properties. The aim of the present study was to investigate the metabolic profile of leelamine in human liver microsomes (HLMs) and mice using liquid chromatography-tandem mass spectrometry (LC-MS/MS). 2. We found that leelamine undergoes only Phase I metabolism, which generates one metabolite that is mono-hydroxylated at the C9 carbon of the octahydrophenanthrene ring (M1) both in vitro and in vivo...
May 23, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29790806/bisphenol-s-modulates-concentrations-of-bisphenol-a-and-oestradiol-in-female-and-male-mice
#13
Tyler Pollock, Lucas J Greville, Rachel E Weaver, Marija Radenovic, Denys deCatanzaro
1. Concern over endocrine-disrupting actions of bisphenol A (BPA) has prompted some manufacturers to remove it from consumer products. Among the chemical replacements in 'BPA-free' products are other bisphenol analogues, such as bisphenol S (BPS). Given evidence that BPA and BPS possess similar oestrogenic activity, their capacity to interact and disrupt oestrogen homeostasis should be examined. 2. We investigated whether BPS can modulate concentrations of 14 C-BPA, exogenous 3 H-oestradiol (E2), or natural E2...
May 23, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29790729/prenatal-phthalates-maternal-thyroid-function-and-risk-of-attention-deficit-hyperactivity-disorder-in-the-norwegian-mother-and-child-cohort
#14
Stephanie M Engel, Gro D Villanger, Rachel C Nethery, Cathrine Thomsen, Amrit K Sakhi, Samantha S M Drover, Jane A Hoppin, Pal Zeiner, Gun Peggy Knudsen, Ted Reichborn-Kjennerud, Amy H Herring, Heidi Aase
BACKGROUND: There is growing concern that phthalate exposures may have an impact on child neurodevelopment. Prenatal exposure to phthalates has been linked with externalizing behaviors and executive functioning defects suggestive of an attention-deficit hyperactivity disorder (ADHD) phenotype. OBJECTIVES: We undertook an investigation into whether prenatal exposure to phthalates was associated with clinically confirmed ADHD in a population-based nested case-control study of the Norwegian Mother and Child Cohort (MoBa) between the years 2003 and 2008...
May 10, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29790623/the-analysis-of-microbial-spectrum-and-antibiotic-resistance-of-uropathogens-isolated-from-patients-with-urinary-stones
#15
Dong Chen, Yuyan Zhang, Jian Huang, Xiongfa Liang, Tao Zeng, Chuangxin Lan, Xiaolu Duan, Zhijian Zhao, Guohua Zeng, Hans-Göran Tiselius, Xiaogang Lu, Wenqi Wu
PURPOSE: The characteristics and resistance patterns of urine bacteriology in patients with urinary tract stones have not been extensively studied. This study aims to investigate the microbial spectrum and antibiotic resistance of uropathogens isolated from urinary tract infections in patients with urinary stones and provide a basis for appropriate antimicrobial treatments. METHODS: The results of positive bladder midstream urine cultures and their antimicrobial susceptibility were retrospectively analysed from hospitalised patients with diagnosis of urinary calculi and urinary tract infections between January 2010 and December 2015...
May 23, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29790490/a-multi-walled-carbon-nanotube-based-magnetic-molecularly-imprinted-polymer-as-a-highly-selective-sorbent-for-ultrasonic-assisted-dispersive-solid-phase-microextraction-of-sotalol-in-biological-fluids
#16
Saeedeh Ansari, Saeed Masoum
A modified multiwalled carbon nanotube-based magnetic molecularly imprinted polymer (MWCNT-MMIP) was synthesized and applied for selective extraction and preconcentration of sotalol (SOT) in biological fluid samples by using ultrasonic-assisted dispersive solid-phase microextraction (UA-DSPME). The synthetic particles were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) analysis, vibrating sample magnetometry (VSM) and Fourier transform infrared spectroscopy (FTIR)...
May 23, 2018: Analyst
https://www.readbyqxmd.com/read/29790390/collecting-duct-principal-but-not-intercalated-cell-prorenin-receptor-regulates-renal-sodium-and-water-excretion
#17
Nirupama Ramkumar, Deborah Stuart, Elena Mironova, Nikita Abraham, Yang Gao, Shuping Wang, Jayalakshmi Lakshmipathi, James D Stockand, Donald E Kohan
The collecting duct is the predominant nephron site of prorenin and prorenin receptor (PRR) expression. We previously demonstrated that the collecting duct PRR regulates epithelial Na+ channel (ENaC) activity and water transport; however, which cell type is involved remains unclear. Herein, we examined the effects of principal cell (PC) or intercalated cell (IC) PRR deletion on renal Na+ and water handling. PC or IC PRR KO mice were obtained by crossing floxed PRR mice with mice harboring Cre recombinase under the control of the AQP2 or B-1 subunit of the H+ ATPase promoters, respectively...
May 23, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29790368/e-iatrogenesis-unnecessary-ordering-of-urine-creatine
#18
Arjun Gupta, Brett Moran
No abstract text is available yet for this article.
May 1, 2018: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/29790336/importance-of-dermal-absorption-of-polycyclic-aromatic-hydrocarbons-derived-from-barbecue-fumes
#19
Jia-Yong Lao, Shan-Yi Xie, Chen-Chou Wu, Lian-Jun Bao, Shu Tao, Eddy Y Zeng
Despite the ubiquity and carcinogenicity of polycyclic aromatic hydrocarbons (PAHs), their dermal absorption for the general population has not been adequately addressed. Aiming to verify the importance of dermal absorption of PAHs, barbecue (BBQ) in Guangzhou, China was chosen as a case study. Urine samples were collected and analyzed for nine hydroxyl (OH)-PAHs. Air, food, and cotton clothing samples were analyzed for 16 PAHs. Dietary exposure was the dominant exposure route with the greatest amounts of OH-PAH excretion and PAH intake...
May 23, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29790320/ultrasonic-standing-wave-preparation-of-a-liquid-cell-for-glucose-measurements-in-urine-by-midinfrared-spectroscopy-and-potential-application-to-smart-toilets
#20
Naoyuki Yamamoto, Natsumi Kawashima, Tomoya Kitazaki, Keita Mori, Hanyue Kang, Akira Nishiyama, Kenji Wada, Ichiro Ishimaru
Smart toilets could be used to monitor different components of urine in daily life for early detection of lifestyle-related diseases and prompt provision of treatment. For analysis of biological samples such as urine by midinfrared spectroscopy, thin-film samples like liquid cells are needed because of the strong absorption of midinfrared light by water. Conventional liquid cells or fixed cells are prepared based on the liquid membrane method and solution technique, but these are not quantitative and are difficult to set up and clean...
May 2018: Journal of Biomedical Optics
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