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https://www.readbyqxmd.com/read/28103662/-strangulation-of-the-penis-by-four-metallic-washers
#1
Yuto Matsushita, Hiroshi Furuse, Rikiya Matsumoto, Takayuki Sugiyama, Masao Nagata, Atsushi Otsuka, Seiichiro Ozono
We report here a case of strangulation of the penis. A 69-year-old male visited our hospital suffering from a swollen penis and dysuria after installation of four metallic washers to the penis. He had mischievously put them on his penis four days before and subsequently was unable to remove them. We found erosion on the surface of the penis, reduction in blood flow by ultrasonography, and high C-reactive protein levels. Because we could not remove washers by blood removal from glans penis or ring cutter, we performed percutaneous cystostomy and then cut the washers with an electric grinder under general anesthesia...
December 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28103517/a-noninvasive-cancer-detection-strategy-based-on-gold-nanoparticle-surface-enhanced-raman-spectroscopy-of-urinary-modified-nucleosides-isolated-by-affinity-chromatography
#2
Shangyuan Feng, Zuci Zheng, Yuanji Xu, Jinyong Lin, Guannan Chen, Cuncheng Weng, Duo Lin, Sufang Qiu, Min Cheng, Zufang Huang, Lan Wang, Rong Chen, Shusen Xie, Haishan Zeng
The search for tumor biomarkers in the urine for cancer diagnosis is currently a hot topic in clinical oncology, with potential for cancer screening and diagnosis. Modified nucleosides excreted through the urine are considered to be a general tumor marker for various cancer types. Herein, we explore a new method that utilizes surface-enhanced Raman scattering (SERS) spectroscopy to obtain a complete biochemical profile of urinary modified nucleosides. In our method, modified nucleosides are first isolated from urine sample utilizing the excellent separation ability of affinity chromatography; then supplemented with gold (Au) nanoparticles as substrate for SERS spectroscopy analysis...
January 5, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28103129/the-role-of-urinary-kim-1-ngal-ca19-9-and-%C3%AE-2-microglobulin-in-the-assessment-of-ureteropelvic-junction-obstruction-in-adults
#3
Eduardo P Miranda, Ricardo Jordão Duarte, José de Bessa, Roberto Iglesias Lopes, Victor Srougi, Hiury Silva Andrade, Rodolfo Ast Bandeira, Marco Antônio Arap, Anuar Ibrahim Mitre, Nayara Izabel Viana, Sabrina Thalita Dos Reis, Kátia Ramos Moreira Leite, Miguel Srougi
PURPOSE: To evaluate the diagnostic properties of urinary biomarkers in adults with ureteropelvic junction obstruction: KIM-1, NGAL, CA19-9, and β2-microglobulin. We also assessed urinary biomarker concentrations following pyeloplasty. MATERIAL AND METHODS: We prospectively studied adults from December 2013 to February 2015. We included 47 patients with a mean age of 38.6 ± 12.7 years. Each patient provided four samples of voided urine for biomarker measurement, one at preoperative consultation and the others at 1, 3 and 6 months of postoperative follow-up...
January 19, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28102816/clinicopathological-features-diagnosis-and-treatment-of-iga-nephropathy-with-minimal-change-disease-related-to-exposure-to-mercury-containing-cosmetics-a-case-report%C3%A2
#4
Hong-Xin Niu, Shen-Heng Li, Hong-Ying Li, Yi-Hua Chen, Wei-Wei Liu, Pei-Lin Li, Hai-Bo Long
AIM: Membranous nephropathy and minimal change disease (MCD) have been involved in mercury-induced nephrotic syndrome. IgA nephropathy is not known to be a common pathological type. In the present article, we report a case of IgA nephropathy with MCD following exposure to mercury-containing skin lightening cream. MATERIAL AND METHODS: The patient was a 39-year-old woman who presented with nephrotic syndrome. She had a 6-month history of using as many as 8 kinds of skin-lightening creams, and urinary mercury excretion was high...
January 19, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28102710/development-and-validation-of-a-uplc-ms-ms-method-for-simultaneous-determination-of-fotagliptin-and-its-two-major-metabolites-in-human-plasma-and-urine
#5
Zhenlei Wang, Ji Jiang, Pei Hu, Qian Zhao
AIM: Fotagliptin is a novel dipeptidyl peptidase IV inhibitor under clinical development for the treatment of Type II diabetes mellitus. The objective of this study was to develop and validate a specific and sensitive ultra-performance liquid chromatography (UPLC)-MS/MS method for simultaneous determination of fotagliptin and its two major metabolites in human plasma and urine. Methodology & results: After being pretreated using an automatized procedure, the plasma and urine samples were separated and detected using a UPLC-ESI-MS/MS method, which was validated following the international guidelines...
January 19, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28102703/glyoxal-and-methylglyoxal-determination-in-urine-by-surfactant-assisted-dispersive-liquid-liquid-microextraction-and-lc
#6
Natalia Campillo, Pilar Viñas, Javier Marín, Manuel Hernández-Córdoba
AIM: Two important markers of oxidative stress, glyoxal and methylglyoxal, are preconcentrated from human urine by surfactant-assisted dispersive liquid-liquid microextraction and separated by LC-fluorescence. METHODS/RESULTS: Derivatization was carried out overnight with 0.8 mM 2,3-diaminonaphthalene at 4°C. For surfactant-assisted dispersive liquid-liquid microextraction, 500 µl buffer solution (pH 10.5) and 25 µl 0.03 M Triton X-114 were added to 2.5 ml of the sample and the mixture was made up to 10 ml before the rapid injection of 75 µl 1-undecanol (extractant solvent) and 0...
January 19, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28102586/creatinine-in-urine-a-method-comparison
#7
Marc Luginbühl, Wolfgang Weinmann
Drug screening in urine is widely applied in forensic toxicology. Contrary to blood analysis, excessive or reduced fluid intake can substantially alter the concentration of substances in urine. As a standard to detect urinary dilution, creatinine concentrations are analyzed. A sample with a concentration below 20 mg/dL is generally defined as too diluted to provide a valid result in abstinence control samples. This work investigates the potential of three different methods for the determination of creatinine concentrations in urine samples: A ZIC-HILIC based LC-MS/MS method, a spectrophotometric method on an AU 480 chemistry system, and a portable, immunoassay based point-of-care testing device was compared by measuring 200 urine samples...
January 19, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28102554/what-are-the-predicting-factors-for-the-therapeutic-effects-of-dutasteride-in-male-patients-with-lower-urinary-tract-symptoms-investigation-using-a-urodynamic-study
#8
Yoshihisa Matsukawa, Masashi Kato, Yasuhito Funahashi, Tsuyoshi Majima, Tokunori Yamamoto, Momokazu Gotoh
AIMS: We investigated predicting factors for the therapeutic effects of dutasteride in patients with lower urinary tract symptoms (LUTS) due to benign prostatic enlargement (BPE) based on a urodynamic study (UDS). METHODS: This was a single-center, prospective study involving 120 male outpatients with LUTS. They received 0.5 mg of dutasteride per day for 12 months. IPSS, OABSS, IPSS-QOL, and UDS were used for assessing subjective and objective symptoms prior to and 12 months after administration...
January 19, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28102552/could-urinary-nerve-growth-factor-be-a-biomarker-for-overactive-bladder%C3%A2-a-meta-analysis
#9
REVIEW
Wei Sheng, Hongwei Zhang, Kirschner-Hermanns Ruth
OBJECTIVE: The previously reported association between urinary nerve growth factor (NGF) and overactive bladder (OAB) was controversial. We performed this meta-analysis based on current available studies to sum up all evidence on this association. METHODS: Studies were identified by searching PubMed, Embase, and Cochrane library from inception to September 2016. Pooled standardized mean difference (SMD) with their corresponding 95% confidence intervals (CIs) were calculated using a random-effects model...
January 19, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28102366/aurora-kinase-a-is-a-biomarker-for-bladder-cancer-detection-and-contributes-to-its-aggressive-behavior
#10
Aaron Mobley, Shizhen Zhang, Jolanta Bondaruk, Yan Wang, Tadeusz Majewski, Nancy P Caraway, Li Huang, Einav Shoshan, Guermarie Velazquez-Torres, Giovanni Nitti, Sangkyou Lee, June Goo Lee, Enrique Fuentes-Mattei, Daniel Willis, Li Zhang, Charles C Guo, Hui Yao, Keith Baggerly, Yair Lotan, Seth P Lerner, Colin Dinney, David McConkey, Menashe Bar-Eli, Bogdan Czerniak
The effects of AURKA overexpression associated with poor clinical outcomes have been attributed to increased cell cycle progression and the development of genomic instability with aneuploidy. We used RNA interference to examine the effects of AURKA overexpression in human bladder cancer cells. Knockdown had minimal effects on cell proliferation but blocked tumor cell invasion. Whole genome mRNA expression profiling identified nicotinamide N-methyltransferase (NNMT) as a downstream target that was repressed by AURKA...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28101889/predictors-of-successful-trial-without-catheter-following-acute-urinary-retention-in-benign-prostatic-enlargement-a-single-centre-multivariate-analysis
#11
Ankur Bansal, Aditi Arora
OBJECTIVE: To evaluate the parameters which predict the success or failure of trial without catheter (TWOC) for acute urine retention (AUR). MATERIALS AND METHODS: Medical records of 2 188 patients presenting with first episode of AUR were analyzed. All patients underwent catheterization and were started on α-blocker followed by TWOC. Age, baseline American urological association (AUA) score, prostate volume (PV), residual volume of urine (RV) and intravesical prostatic protrusion (IPP), prostate specific antigen (PSA) were recorded...
January 19, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28101752/the-impact-of-hydrocortisone-treatment-on-neutrophil-gelatinase-associated-lipocalin-release-in-porcine-endotoxemic-shock
#12
E Söderberg, M Eriksson, A Larsson, M Lipcsey
BACKGROUND: A key feature of sepsis is systemic inflammatory activation that could be counteracted by steroids. In this experimental model of systemic inflammation, we sought to investigate whether septic neutrophil activation, evaluated by the plasma levels of neutrophil gelatinase-associated protein (NGAL), is modulated by the timing of hydrocortisone treatment. METHODS: Sixteen anesthetized pigs were allocated to one of four equally sized groups. Three of these groups received endotoxin at 2 μg × kg(-1) × h(-1) for 6 h so as to induce endotoxemic shock...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28101652/alteration-of-metabolomic-markers-of-amino-acid-metabolism-in-piglets-with-in-feed-antibiotics
#13
Chunlong Mu, Yuxiang Yang, Kaifan Yu, Miao Yu, Chuanjian Zhang, Yong Su, Weiyun Zhu
In-feed antibiotics have been used to promote growth in piglets, but its impact on metabolomics profiles associated with host metabolism is largely unknown. In this study, to test the hypothesis that antibiotic treatment may affect metabolite composition both in the gut and host biofluids, metabolomics profiles were analyzed in antibiotic-treated piglets. Piglets were fed a corn-soy basal diet with or without in-feed antibiotics from postnatal day 7 to day 42. The serum biochemical parameters, metabolomics profiles of the serum, urine, and jejunal digesta, and indicators of microbial metabolism (short-chain fatty acids and biogenic amines) were analyzed...
January 18, 2017: Amino Acids
https://www.readbyqxmd.com/read/28101501/classical-presentation-of-acute-pyelonephritis-in-a-case-of-brucellosis
#14
Wadha Alfouzan, Sara Al-Sahali, Hawra'a Sultan, Rita Dhar
Although Brucella species is known to affect almost all organs in humans, renal involvement presenting as acute pyelonephritis remains a rare entity in brucellosis. We report the case of a female patient who presented with symptoms of fever with chills, right loin pain and dysuria in the emergency room. Blood cultures drawn at the time of admission grew Brucella spp., but no organisms were isolated from urine culture although urinalysis data was indicative of urinary tract infection. Empiric therapy with piperacillin/tazobactam plus gentamicin relieved her symptoms...
May 2016: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/28101461/acute-and-subchronic-toxicity-study-of-the-median-septum-of-juglans-regia-in-wistar-rats
#15
Asma Ravanbakhsh, Majid Mahdavi, Ghader Jalilzade-Amin, Shahram Javadi, Masoud Maham, Daryosh Mohammadnejad, Mohammad Reza Rashidi
Purpose: Median septum of Juglans regia L. (Juglandaceae) with anti-diabetic effects has been used in Iranian traditional medicine. The present study estimates both oral acute and subchronic toxicities. Methods: In the oral acute toxicity study, female Wistar rats were treated with doses of 10, 100, 1000, 1600, 2900 and 5000 mg/ kg of the Juglans regia septum of methanol extract (JRSME), and were monitored for 14 days. In subchronic study, JRSME was administered by gavage at dose of 1000 mg/kg daily in Wistar rats for 28 days...
December 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28101180/acute-renal-injury-induced-by-valacyclovir-hydrochloride-a-case-report
#16
Yanning Zhang, Yuxi Cong, Yan Teng
Acyclovir has been a frequently used antiviral agent in the clinical treatment of leukemia, acute encephalitis, malignant tumor and herpes simplex. The adverse effects of this drug have been widely described in clinical practice. In the present study, a case of a 35-year-old female patient diagnosed with herpes simplex, who developed acute renal injury following treatment with valacyclovir hydrochloride, is described. Kidney biopsy, light microscopy and laboratory examination were performed, and all findings revealed the signs of evident vacuolar degeneration of capillary endothelial and renal tubular epithelial cells, erythrocyte aggregation in partial renal tubule and microvilli exfoliation from epithelial cells...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28101130/silica-titania-xerogel-doped-with-mo-p-heteropoly-compounds-for-solid-phase-spectrophotometric-determination-of-ascorbic-acid-in-fruit-juices-pharmaceuticals-and-synthetic-urine
#17
Maria A Morosanova, Elena I Morosanova
BACKGROUND: Ascorbic acid is one of the most important vitamins to monitor in dietary sources (juices and vitamins) and biological liquids. RESULTS: Silica and silica-titania xerogels doped with Mo,P-heteropoly compounds (HPC) have been synthesized varying titanium(IV) and HPC content in sol. Their surface area and porosity have been studied with nitrogen adsorption and scanning electron microscopy, their elemental composition has been studied with energy-dispersive X-ray analysis...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28101123/regulatory-landscape-of-age-rage-oxidative-stress-axis-and-its-modulation-by-ppar%C3%AE-activation-in-high-fructose-diet-induced-metabolic-syndrome
#18
Luca Cannizzaro, Giuseppe Rossoni, Federica Savi, Alessandra Altomare, Cristina Marinello, Thammakorn Saethang, Marina Carini, D Michael Payne, Trairak Pisitkun, Giancarlo Aldini, Asada Leelahavanichkul
BACKGROUND: The AGE-RAGE-oxidative stress (AROS) axis is involved in the onset and progression of metabolic syndrome induced by a high-fructose diet (HFD). PPARγ activation is known to modulate metabolic syndrome; however a systems-level investigation looking at the protective effects of PPARγ activation as related to the AROS axis has not been performed. The aim of this work is to simultaneously characterize multiple molecular parameters within the AROS axis, using samples taken from different body fluids and tissues of a rat model of HFD-induced metabolic syndrome, in the presence or absence of a PPARγ agonist, Rosiglitazone (RGZ)...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28100920/within-country-variation-of-salt-intake-assessed-via-urinary-excretion-in-japan-a-multilevel-analysis-in-all-47-prefectures
#19
Ken Uechi, Keiko Asakura, Shizuko Masayasu, Satoshi Sasaki
Salt intake in Japan remains high; therefore, exploring within-country variation in salt intake and its cause is an important step in the establishment of salt reduction strategies. However, no nationwide evaluation of this variation has been conducted by urinalysis. We aimed to clarify whether within-country variation in salt intake exists in Japan after adjusting for individual characteristics. Healthy men (n=1027) and women (n=1046) aged 20-69 years were recruited from all 47 prefectures of Japan. Twenty-four-hour sodium excretion was estimated using three spot urine samples collected on three nonconsecutive days...
January 19, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28100605/urine-24-hour-sodium-excretion-decreased-between-1953-and-2014-in-japan-but-estimated-intake-still-exceeds-the-who-recommendation
#20
Ken Uechi, Minami Sugimoto, Satomi Kobayashi, Satoshi Sasaki
BACKGROUND: Accurate monitoring of sodium intake is necessary for evaluating strategies used to reduce sodium intake. However, no repeat survey has been conducted in representative populations in Japan to examine trends in sodium intake with the use of 24-h urinary sodium excretion, a standard evaluation method for sodium intake monitoring. OBJECTIVE: The objective of this study was to examine potential trends in sodium intake by examining previous reports of 24-h urinary sodium excretion in healthy Japanese adult populations...
January 18, 2017: Journal of Nutrition
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