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Nathan D Wiebracht, John P Giliberto, Charles Myer, Keith Casper, Kaalan E Johnson
OBJECTIVES/HYPOTHESIS: Restrictions on resident work hours and the increasing purview of otolaryngology reduce the efficacy of the traditional surgical training model. With limited case volumes at many institutions and the unique instrumentation of endoscopic Zenker's diverticulotomy (EZD), simulation may be useful to improve training. In this study, a novel surgical simulator for EZD is developed and validated. STUDY DESIGN: Simulation model development. METHODS: An EZD model was designed using an intubation trainer and disposable diverticulum inserts...
November 30, 2016: Laryngoscope
Dominik Ziehe, Beatrix Dünschede, Mira Zenker, Silke Funke, Marc M Nowaczyk, Danja Schünemann
The bacterial signal recognition particle (SRP) mediates the cotranslational targeting of membrane proteins and is a high affinity complex consisting of a SRP54 protein subunit (Ffh) and an SRP RNA. The chloroplast SRP (cpSRP) pathway has adapted throughout evolution to enable the posttranslational targeting of the light harvesting chlorophyll a/b binding proteins (LHCPs) to the thylakoid membrane. In spermatophytes (seed plants), the cpSRP lacks the SRP RNA and is instead formed by a high affinity interaction of the conserved 54-kD subunit (cpSRP54) with the chloroplast-specific cpSRP43 protein...
2016: PloS One
Tyler House, Patrick D Webb
No abstract text is available yet for this article.
August 2016: ACG Case Reports Journal
Tulio F Leite, Carlos A A Chagas, Lucas A S Pires, Rafael Cisne, Marcio A Babinski
Zenker's diverticulum is a form of esophageal and pharyngeal obstruction located at the Killian-Laimer triangle. It is relatively common in elderly man (seventh or eighth decade of life), and its pathophysiology is not completely understood, albeit theories regarding dysfunction of the upper esophageal sphincter were reported. The main symptoms are dysphagia and odynophagia, but it can complicate to aspiration and perforation of the pharyngeal pouch; also, it can be asymptomatic. Diagnosis is provided through a barium esophagogram...
December 2015: Gastroenterology Research
M Hoffmann, A Fazel, K-G Mews, P Ambrosch
OBJECTIVES: To underline the value of the microendoscopic CO2 -LASER-assisted treatment (MEDCO2 ) for Zenker's diverticulum by investigating a large patient cohort treated in a single medical centre. DESIGN: Retrospective cohort study of consecutive patients. SETTING: Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University Kiel, Germany. PARTICIPANTS: A total of 227 patients with Zenker's diverticulum were treated by MEDCO2 , and the results were compared with those reported in the literature for the open transcervical approach (OTA) and the endoscopic staple-assisted oesophagodiverticulostomy (ESED)...
October 19, 2016: Clinical Otolaryngology
Martin Zenker, Kerstin Kutsche
No abstract text is available yet for this article.
December 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Quan-Lin Li, Wei-Feng Chen, Xiao-Cen Zhang, Ming-Yan Cai, Yi-Qun Zhang, Jian-Wei Hu, Meng-Jiang He, Li-Qing Yao, Ping-Hong Zhou, Mei-Dong Xu
No abstract text is available yet for this article.
December 2016: Gastroenterology
Ryan E Little, Jonathan M Bock
PURPOSE OF REVIEW: Pharyngoesophageal diverticuli such as Zenker's diverticulum are relatively rare diseases that may have a significant impact on a patient's quality of life. Open surgical techniques have historically been the mainstay of treatment for Zenker's diverticuli and remain the preferred approach for many surgeons operating on Killian-Jamieson diverticuli (KJD) and pharyngoceles. However, advances in technology in recent decades have allowed for the development of successful endoscopic surgical techniques for the management of these conditions...
September 15, 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
Meike Hohwieler, Anett Illing, Patrick C Hermann, Tobias Mayer, Marianne Stockmann, Lukas Perkhofer, Tim Eiseler, Justin S Antony, Martin Müller, Susanne Renz, Chao-Chung Kuo, Qiong Lin, Matthias Sendler, Markus Breunig, Susanne M Kleiderman, André Lechel, Martin Zenker, Michael Leichsenring, Jonas Rosendahl, Martin Zenke, Bruno Sainz, Julia Mayerle, Ivan G Costa, Thomas Seufferlein, Michael Kormann, Martin Wagner, Stefan Liebau, Alexander Kleger
OBJECTIVE: The generation of acinar and ductal cells from human pluripotent stem cells (PSCs) is a poorly studied process, although various diseases arise from this compartment. DESIGN: We designed a straightforward approach to direct human PSCs towards pancreatic organoids resembling acinar and ductal progeny. RESULTS: Extensive phenotyping of the organoids not only shows the appropriate marker profile but also ultrastructural, global gene expression and functional hallmarks of the human pancreas in the dish...
September 15, 2016: Gut
Nitin Aggarwal, Prashanthi N Thota
No abstract text is available yet for this article.
September 2016: Cleveland Clinic Journal of Medicine
George Orthopoulos, Brad S Oriel, C Jeff Siegert, Abraham Lebenthal, John Gooey, P Marco Fisichella
The transoral division of the esophageal-diverticula septum with a linear stapler, with CO2 laser, or with harmonic scalpel under rigid endoscopy has revolutionized the surgical management of Zenker's diverticula. Nevertheless, the open approach still plays a role in select cases. Our goals are to illustrate the techniques and the results of our tailored approach to the surgical management of Zenker's diverticula in U.S. veterans.
October 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Vinay G Zanwar, Pravir A Gambhire, Ajay S Choksey, Pravin M Rathi
Killian-Jamieson (K-J) diverticulum is an outpouching from the lateral wall of the proximal cervical oesophagus and is less commonly encountered compared to Zenker's diverticulum (ZD). These diverticulae arise between the fibers of the cricopharyngeus muscle superiorly and longitudinal muscle of the oesophagus inferiorly. In this report we present a case of a symptomatic Killian Jamieson diverticulum and review the clinical presentation, differential diagnosis and radiological findings that distinguish it from the more common Zenker's diverticulum...
November 2015: Journal of the Association of Physicians of India
Débora V Albers, André Kondo, Wanderley M Bernardo, Paulo Sakai, Renata Nobre Moura, Gustavo Luis Rodela Silva, Edson Ide, Toshiro Tomishige, Eduardo G H de Moura
BACKGROUND: Zenker's diverticulum is a rare disease in the general population. Its treatment can be carried out by either an endoscopic or surgical approach. The objective of this study was to systematically identify all reports that compare both treatment modalities and to assess the outcomes in terms of length of procedure, length of hospitalization, time until diet introduction, complication rates, and recurrence rates. METHODS: A search of Medline and Embase selected all studies that compared different methods of surgical and endoscopic treatment for Zenker's diverticulum published in the English, Portuguese, and Spanish languages between 1975 and 2014...
June 2016: Endoscopy International Open
Jong Myung Park, Chang Wan Kim, Do Hyung Kim
A pharyngeal diverticulum is a rare complication of an anterior cervical discectomy and fusion (ACDF). We present a case of a pharyngeal diverticulum after an ACDF, which was misdiagnosed as a typical Zenker diverticulum. A 54-year-old woman presented with dysphagia and a sense of irritation in the neck following C5 through C7 cervical fusion 3 years prior. The patient underwent open surgery to resect the diverticulum with concurrent cricopharyngeal myotomy. An ACDF-related diverticulum is difficult to distinguish from a typical Zenker diverticulum...
August 2016: Korean Journal of Thoracic and Cardiovascular Surgery
Alexander P Marston, Francisco J Maldonado, Karthik Ravi, Jan L Kasperbauer, Dale C Ekbom
OBJECTIVE: To compare swallowing outcomes following cricopharyngeal (CP) dilation versus surgical myotomy in patients with dysphagia secondary to idiopathic CP bar. METHODS: All patients had an idiopathic CP bar without a history of Zenker's diverticulum, head and neck cancer, or systemic neurologic disease treated between 2000 and 2013. The Functional Outcome Swallowing Scale (FOSS) was utilized to assess dysphagia symptoms. RESULTS: Twenty-three patients underwent 46 dilations and 20 patients had a myotomy...
July 27, 2016: American Journal of Otolaryngology
Denys Gibbons, Michael Camilleri, Alfred D Nelson, Deborah Eckert
BACKGROUND: Gastrointestinal symptoms are frequent in multiple endocrine neoplasia (MEN) 2B and may be related to megacolon. OBJECTIVE: The objective of this article is to review the clinical features of patients with MEN 2B, particularly megacolon. METHODS: We used natural language processing of electronic medical records of Mayo Clinic patients over 20 years: Eight patients with definite MEN 2B were identified; of these, four had megacolon...
June 2016: United European Gastroenterology Journal
Antonio Carlos Ribeiro-Filho, Marcus Vinicius Buri, Carlos Castilho Barros, Juliana Luporini Dreyfuss, Helena Bonciani Nader, Giselle Zenker Justo, Rogério Bastos Craveiro, João Bosco Pesquero, Antonio Miranda, Alice Teixeira Ferreira, Edgar Julian Paredes-Gamero
BACKGROUND: All hematopoietic cells express P2 receptors, however pharmacological characteristics such as expression and affinity in granulocytes are unknown. METHODS: Pharmacological characteristics of P2 receptors were evaluated by Ca(2+) measurements using Fura-2 fluorophore. P2 receptors expression were analyzed by flow cytometry and RT-PCR. P2 interaction were shown by coimmunoprecipitation, western blotting and FRET. RESULTS: Granulocytes were responsive to P2Y agonists, whereas P2X agonists were ineffective...
2016: BMC Pharmacology & Toxicology
Stephanie Hucke, Martin Herold, Marie Liebmann, Nicole Freise, Maren Lindner, Ann-Katrin Fleck, Stefanie Zenker, Stephanie Thiebes, Juncal Fernandez-Orth, Dorothea Buck, Felix Luessi, Sven G Meuth, Frauke Zipp, Bernhard Hemmer, Daniel Robert Engel, Johannes Roth, Tanja Kuhlmann, Heinz Wiendl, Luisa Klotz
Innate immune responses by myeloid cells decisively contribute to perpetuation of central nervous system (CNS) autoimmunity and their pharmacologic modulation represents a promising strategy to prevent disease progression in Multiple Sclerosis (MS). Based on our observation that peripheral immune cells from relapsing-remitting and primary progressive MS patients exhibited strongly decreased levels of the bile acid receptor FXR (farnesoid-X-receptor, NR1H4), we evaluated its potential relevance as therapeutic target for control of established CNS autoimmunity...
September 2016: Acta Neuropathologica
Vini Balakrishnan, Zachariah Chandy, Sunil P Verma
OBJECTIVE: Patients use a multitude of resources to learn about Zenker's diverticulum (ZD). The objectives of this study were to assess the readability and understandability of online materials on ZD, evaluate them against the existing criteria, and investigate the relationship between readability and understandability. METHODS: The first 50 webpages from an online search for ZD were analyzed. Twenty-one webpages had materials intended for patients and were included in the study...
June 21, 2016: Otolaryngology—Head and Neck Surgery
Lianyong Li, Sarah Cristofaro, Changmin Qu, Shuwen Liang, Qiang Cai
No abstract text is available yet for this article.
June 17, 2016: Gastrointestinal Endoscopy
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