Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Marco Stellato, Sebastiano Buti, Marco Maruzzo, Maria Bassanelli, Melissa Bersanelli, Marilena Di Napoli, Michele Dionese, Martina Fanelli, Roberto Filippi, Giuseppe Fotia, Luca Galli, Francesco Grillone, Michele Maffezzoli, Brigida Anna Maiorano, Cecilia Nasso, Sara Elena Rebuzzi, Luca Lalli, Giandomenico Roviello, Mariella Sorarù, Bruno Vincenzi, Giuseppe Procopio, Elena Verzoni
BACKGROUND: Peritoneal metastases (PM) have been reported in approximately 1% of patients with metastatic Renal Cell Carcinoma (mRCC). Outcome data are limited due to the rarity of this metastatic site. Therefore, the aim of our study is to describe renal cell carcinoma (RCC) patients with PM treated as per clinical practice. MATERIALS AND METHODS: Baseline characteristics and outcome data of patients with PM from RCC were retrospectively collected from 18 Italian oncological referral centers adhering to the Meet-Uro group, from January 2016 to January 2023...
March 19, 2024: Clinical Genitourinary Cancer
#2
JOURNAL ARTICLE
Mariella Hurtado Silva, Ashley J van Waardenberg, Aya Mostafa, Susanne Schoch, Dirk Dietrich, Mark E Graham
To investigate the phosphorylation-based signaling and protein changes occurring early in epileptogenesis, the hippocampi of mice treated with pilocarpine were examined by quantitative mass spectrometry at 4 and 24 h post-status epilepticus at vast depth. Hundreds of posttranscriptional regulatory proteins were the major early targets of increased phosphorylation. At 24 h, many protein level changes were detected and the phosphoproteome continued to be perturbed. The major targets of decreased phosphorylation at 4 and 24 h were a subset of postsynaptic density scaffold proteins, ion channels, and neurotransmitter receptors...
April 19, 2024: IScience
#3
JOURNAL ARTICLE
Karina Sato-Espinoza, Perapa Chotiprasidhi, Mariella R Huaman, Javier Díaz-Ferrer
BACKGROUND: A new nomenclature consensus has emerged for liver diseases that were previously known as non-alcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD). They are now defined as metabolic dysfunction-associated steatotic liver disease (MASLD), which includes cardiometabolic criteria in adults. This condition, extensively studied in obese or overweight patients, constitutes around 30% of the population, with a steady increase worldwide...
March 27, 2024: World Journal of Hepatology
#4
JOURNAL ARTICLE
Vincent Kendlbacher, Teresa Maria Rosa Winter, Monika Bright
Ciliates are unicellular eukaryotes, regularly involved in symbiotic associations. Symbionts may colonize the inside of their cells as well as their surface as ectosymbionts. Here, we report on a new ciliate species, designated as Zoothamnium mariella sp. nov. (Peritrichia, Sessilida), discovered in the northern Adriatic Sea (Mediterranean Sea) in 2021. We found this ciliate species to be monospecifically associated with a new genus of ectosymbiotic bacteria, here proposed as Candidatus Fusimicrobium zoothamnicola gen...
2024: PloS One
#5
REVIEW
Eleftheria Iliadou, Mariella Fortune-Ely, Lauren E Melley, Razmig Garabet, Robert T Sataloff, John S Rubin
OBJECTIVES: This study aimed to provide a comprehensive overview of the systematic reviews that focus on the prevalence of voice disorders (VDs), associated risk factors, and the demographic characteristics of patients with dysphonia. An umbrella review was conducted to identify general research themes in voice literature that might guide future research initiatives and contribute to the classification of VDs as a worldwide health concern. STUDY DESIGN: Umbrella review of systematic reviews...
March 30, 2024: Journal of Voice
#6
JOURNAL ARTICLE
Mariella Särestöniemi, Daljeet Singh, Rakshita Dessai, Charline Heredia, Sami Myllymäki, Teemu Myllylä
The development of new medical-monitoring applications requires precise modeling of effects on the human body as well as the simulation and the emulation of realistic scenarios and conditions. The first aim of this paper is to develop realistic and adjustable 3D human-body emulation platforms that could be used for evaluating emerging microwave-based medical monitoring/sensing applications such as the detection of brain tumors, strokes, and breast cancers, as well as for capsule endoscopy studies. New phantom recipes are developed for microwave ranges for phantom molds with realistic shapes...
March 20, 2024: Sensors
#7
JOURNAL ARTICLE
Cristina Matteo, Isabella Orienti, Adriana Eramo, Ann Zeuner, Mariella Ferrari, Alice Passoni, Renzo Bagnati, Marianna Ponzo, Ezia Bello, Massimo Zucchetti, Roberta Frapolli
We describe the development and validation of a HPLC-MS/MS method to assess the pharmacokinetics and tumor distribution of fenretinide, a synthetic retinoid chemically related to all-trans-retinoic acid, after administration of a novel oral nanoformulation of fenretinide, called bionanofenretinide (BNF). BNF was developed to overcome the major limitation of fenretinide: its poor aqueous solubility and bioavailability due to its hydrophobic nature. The method proved to be reproducible, precise and highly accurate for the measurement of the drug and the main metabolites...
March 12, 2024: Pharmaceutics
#8
JOURNAL ARTICLE
Sergio Pillon, Georgia Gomatou, Evangelos Dimakakos, Agata Stanek, Zsolt Pecsvarady, Matija Kozak, Jean-Claude Wautrecht, Katalin Farkas, Gerit-Holger Schernthaner, Mariella Catalano, Aleš Blinc, Grigorios Gerotziafas, Pavel Poredoš, Sergio De Marchi, Michael E Gschwandtner, Endre Kolossváry, Muriel Sprynger, Bahar Fazeli, Aaron Liew, Peter Marschang, Andrzej Szuba, Dusan Suput, Michael Edmonds, Chris Manu, Christian Alexander Schaefer, George Marakomichelakis, Majda Vrkić Kirhmajer, Jonas Spaak, Elias Kotteas, Gianfranco Lessiani, Mary Paola Colgan, Marc Righini, Michael Lichtenberg, Oliver Schlager, Caitriona Canning, Antonella Marcoccia, Anastasios Kollias, Alberta Spreafico
Background: Telemedicine is increasingly used in several fields of healthcare, including vascular medicine. This study aimed to investigate the views of experts and propose clinical practice recommendations on the possible applications of telemedicine in vascular medicine. Methods: A clinical guidance group proposed a set of 67 clinical practice recommendations based on the synthesis of current evidence and expert opinion. The Telemedicine Vascular Medicine Working Group included 32 experts from Europe evaluating the appropriateness of each clinical practice recommendation based on published RAND/UCLA methodology in two rounds...
March 18, 2024: Journal of Clinical Medicine
#9
JOURNAL ARTICLE
Antonella Rosa, Franca Piras, Federica Pollastro, Valeria Sogos, Giovanni Appendino, Mariella Nieddu
Melanoma is a skin cancer caused by the malignant transformation of melanocytes and cutaneous melanoma represents the most aggressive and deadliest type of skin cancer with an increasing incidence worldwide. The main purpose of the present research was to evaluate the anticancer effects of the natural bioactive compounds xanthomicrol (XAN) and eupatilin (EUP) in human A375 malignant skin melanoma cells, a cell line widely used as an in vitro model of cutaneous melanoma. XAN and EUP are lipophilic methoxylated flavones with antioxidant, anti-inflammatory, and antitumor properties...
February 26, 2024: Life
#10
JOURNAL ARTICLE
Asma Guizani, Elyes Babay, Hend Askri, Mariella Finetti Sialer, Fatma Gharbi
BACKGROUND: The future predictions for frequent and severe droughts will represent a significant threat to wheat yield and food security. In this context, breeding has proven to be the most efficient approach to enhance wheat productivity in dry environments. METHODS AND RESULTS: In this study, both agronomic and molecular-based approaches were used to evaluate the response of twenty-eight Tunisian wheat varieties to drought stress. The primary objective was to screen these varieties for drought tolerance using molecular and agro-morphological markers...
March 23, 2024: Molecular Biology Reports
#11
JOURNAL ARTICLE
Maria Amalia Pesantes, Mariella Bazán Macera, Sabine Mercier, Pamela Giselle Katic
Amazonian Indigenous Peoples are undergoing drastic changes in their ways of life including the quality and availability of food and its impact on their health and well-being. Indigenous populations have their own perspectives and interpretations of dietary changes unfolding in their communities. Based on in-depth interviews, observations and validation workshops we explored the way Awajún describe and problematise the concept of healthy and unhealthy food in the context of the nutrition transition. We learn that the characteristics of 'good food' are informed by their capacity to give strength, protect health and enable them to be hardworking people...
January 2024: Global Public Health
#12
JOURNAL ARTICLE
Hawraz Ibrahim M Amin, Kamaran Younis M Amin, Chabaco Armijos, Faiq H S Hussain, Zanko Hassan Jawhar, Diego Caprioglio, Mariella Mella, Giovanni Vidari
A new glucosyl flavone, 5,7,2',5'-tetrahydroxyflavone 7- O -β-d-glucopyranoside, named loeflingiin, together with apigenin 6- C -glucoside (isovitexin), coumarins citropten and isompinellin, triterpenoids betulin and betulinic acid, and a mixture of phytosterols β-sitosterol, stigmasterol and campesterol were isolated for the first time from the leaves of wild Plantago loeflingii L. ( Plantaginaceae ) collected in the Iraqi Kurdistan region. The plant is used by local people to treat wounds and as a vulnerary remedy...
February 29, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#13
JOURNAL ARTICLE
F Perina, J Mariella, N Ellero, F Freccero, C Castagnetti, A Lanci
In neonatal foals, umbilical remnants can be affected by infectious and non-infectious diseases. This study aimed to retrospectively evaluate historical, management and clinical factors that may be related to the occurrence of umbilical remnant diseases. Clinical reports of foals born or hospitalized within 24h of life during the 2017-2021 foaling seasons were reviewed. Forty/183 foals (21.9%) developed umbilical remnant diseases (URD group), while 143/183 foals (78.1%) had normal umbilical remnants (NUR group)...
March 10, 2024: Journal of Equine Veterinary Science
#14
JOURNAL ARTICLE
Elisa Mariella, Gaia Grasso, Martina Miotto, Kristi Buzo, Nicole Megan Reilly, Pietro Andrei, Pietro Paolo Vitiello, Giovanni Crisafulli, Sabrina Arena, Giuseppe Rospo, Giorgio Corti, Annalisa Lorenzato, Carlotta Cancelliere, Ludovic Barault, Giulia Gionfriddo, Michael Linnebacher, Mariangela Russo, Federica Di Nicolantonio, Alberto Bardelli
Multiple strategies are continuously being explored to expand the drug target repertoire in solid tumors. We devised a novel computational workflow for transcriptome-wide gene expression outlier analysis that allows the systematic identification of both overexpression and underexpression events in cancer cells. Here, it was applied to expression values obtained through RNA sequencing in 226 colorectal cancer (CRC) cell lines that were also characterized by whole-exome sequencing and microarray-based DNA methylation profiling...
March 11, 2024: Molecular Oncology
#15
JOURNAL ARTICLE
Claire Lanaud, Hélène Vignes, José Utge, Gilles Valette, Bénédicte Rhoné, Mariella Garcia Caputi, Natalia Sofía Angarita Nieto, Olivier Fouet, Nilesh Gaikwad, Sonia Zarrillo, Terry G Powis, Ann Cyphers, Francisco Valdez, S Quirino Olivera Nunez, Camilla Speller, Michael Blake, Fred Jr Valdez, Scott Raymond, Sarah M Rowe, Guy S Duke, Francisco Ernesto Romano, Rey Gaston Loor Solórzano, Xavier Argout
Humans have a long history of transporting and trading plants, contributing to the evolution of domesticated plants. Theobroma cacao originated in the Neotropics from South America. However, little is known about its domestication and use in these regions. In this study, ceramic residues from a large sample of pre-Columbian cultures from South and Central America were analyzed using archaeogenomic and biochemical approaches. Here we show, for the first time, the widespread use of cacao in South America out of its native Amazonian area of origin, extending back 5000 years, likely supported by cultural interactions between the Amazon and the Pacific coast...
March 7, 2024: Scientific Reports
#16
JOURNAL ARTICLE
Florian J Gisdon, Mariella Zunker, Jan Niclas Wolf, Kai Prüfer, Jörg Ackermann, Christoph Welsch, Ina Koch
MOTIVATION: The functional complexity of biochemical processes is strongly related to the interplay of proteins and their assembly into protein complexes. In recent years, the discovery and characterization of protein complexes have substantially progressed through advances in cryo-electron microscopy, proteomics, and computational structure prediction. This development results in a strong need for computational approaches to analyse the data of large protein complexes for structural and functional characterization...
March 6, 2024: Bioinformatics
#17
JOURNAL ARTICLE
Leonardo Tenfen, Richard Simon Machado, Khiany Mathias, Natalia Piacentini, Larissa Joaquim, Sandra Bonfante, Lucineia Gainski Danielski, Nicole Alessandra Engel, Mariella Reinol da Silva, Gislaine Tezza Rezin, Rafaella Willig de Quadros, Fernanda Frederico Gava, Fabricia Petronilho
BACKGROUND: Oxygen therapy is an alternative for many patients with hypoxemia. However, this practice can be dangerous as oxygen is closely associated with the development of oxidative stress. METHODS: Male Wistar rats were exposed to hyperoxia with a 40% fraction of inspired oxygen (FIO2 ) and hyperoxia (FIO2 = 60%) for 120 min. Blood and lung tissue samples were collected for gas, oxidative stress, and inflammatory analyses. RESULTS: Hyperoxia (FIO2 = 60%) increased PaCO2 and PaO2 , decreased blood pH and caused thrombocytopenia and lymphocytosis...
March 6, 2024: Inhalation Toxicology
#18
JOURNAL ARTICLE
Keila Rufatto de Souza, Nicole Alessandra Engel, Hevylin Jacinto Soares, Catarina Barbosa Chaves Bressan, Larissa Marques Dela Vedova, Larissa Espindola da Silva, Talita Farias Mendes, Mariella Reinol da Silva, Mariana Pacheco de Oliveira, Amanda Indalecio Goulart, Emily Córneo, Heloísa de Medeiros Borges, Monique Michels, João Vitor Silvano Bittencourt, Laura de Roch Casagrande, Gabriela Kozuchovski Ferreira, Fabricia Cardoso Petronilho, Felipe Dal-Pizzol, Paulo Cesar Lock Silveira, Rafael Mariano de Bitencourt, Marina Goulart da Silva, Gislaine Tezza Rezin
Obesity results from an energy imbalance and has been considered an epidemic due to its increasing rates worldwide. It is classified as a low-grade chronic inflammatory disease and has associated comorbidities. Different nutritional strategies are used for the purpose of weight loss, highlighting low-carbohydrate (LC) diets, ketogenic diets, and intermittent fasting (IF). These strategies can lead to metabolic and behavioral changes as they stimulate different biochemical pathways. Therefore, this study evaluated memory, energy metabolism, neuroinflammation, oxidative stress, and antioxidant defense parameters in mice subjected to an LC diet, ketogenic diet (KD), or IF...
March 2, 2024: Metabolic Brain Disease
#19
JOURNAL ARTICLE
Edoardo G Giannini, Andrea Pasta, Giulia Pieri, Maria Corina Plaz Torres, Mariarosaria Marseglia, Filippo Pelizzaro, Angelo Sangiovanni, Giuseppe Cabibbo, Giorgia Ghittoni, Mariella Di Marco, Francesco Giuseppe Foschi, Maria Guarino, Elisabetta Biasini, Carlo Saitta, Claudia Campani, Gianluca Svegliati-Baroni, Antonio Gasbarrini, Maurizia Rossana Brunetto, Donatella Magalotti, Francesco Azzaroli, Andrea Mega, Rodolfo Sacco, Gerardo Nardone, David Sacerdoti, Alberto Masotto, Gianpaolo Vidili, Laura Bucci, Alessandro Vitale, Franco Trevisani
BACKGROUND & AIMS: Chronic hepatitis D virus (HDV) often leads to end-stage liver disease and hepatocellular carcinoma (HCC). Comprehensive data pertaining to large populations with HDV and HCC are missing, therefore we sought to assess the characteristics, management, and outcome of these patients, comparing them to patients with hepatitis B virus (HBV) infection. METHODS: We analysed the Italian Liver Cancer database focusing on patients with positivity for HBV surface antigen and anti-HDV antibodies (HBV/HDV, n = 107) and patients with HBV infection alone (n = 588)...
March 1, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
#20
JOURNAL ARTICLE
Gabriele Scozia, Mario Pinto, Silvana Lozito, Nicola Binetti, Mariella Pazzaglia, Stefano Lasaponara, Fabrizio Doricchi
Humans use space to think of and communicate the flow of time. This spatial representation of time is influenced by cultural habits so that in left-to-right reading cultures, short durations and past events are mentally positioned to the left of long durations and future events. The STEARC effect (Space Temporal Association of Response Codes) shows a faster classification of short durations/past events with responses on the left side of space and of long durations/future events with responses on the right side...
February 27, 2024: Attention, Perception & Psychophysics
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
