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https://www.readbyqxmd.com/read/29339549/apol1-genotype-and-renal-function-of-black-living-donors
#1
Mona D Doshi, Mariella Ortigosa-Goggins, Amit X Garg, Lihua Li, Emilio D Poggio, Cheryl A Winkler, Jeffrey B Kopp
Black living kidney donors are at higher risk of developing kidney disease than white donors. We examined the effect of the APOL1 high-risk genotype on postdonation renal function in black living kidney donors and evaluated whether this genotype alters the association between donation and donor outcome. We grouped 136 black living kidney donors as APOL1 high-risk (two risk alleles; n=19; 14%) or low-risk (one or zero risk alleles; n=117; 86%) genotype. Predonation characteristics were similar between groups, except for lower mean±SD baseline eGFR (CKD-EPI equation) in donors with the APOL1 high-risk genotype (98±17 versus 108±20 ml/min per 1...
January 16, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29335783/maternal-and-neonatal-omentin-1-levels-in-gestational-diabetes
#2
Marie Franz, Mariella Polterauer, Stephanie Springer, Lorenz Kuessel, Peter Haslinger, Christof Worda, Katharina Worda
PURPOSE: To evaluate the effect of gestational diabetes on omentin-1 in maternal and cord plasma. As a potent mediator of insulin resistance, Omentin-1, an adipokine derived from human adipose and placental tissue, may be an important player in the pathophysiology of gestational diabetes. METHODS: This was a prospective case-control study. The study included 96 women with gestational diabetes and 96 pregnant women without. Omentin-1 was measured at the time of the oral glucose tolerance test, at 32 weeks in maternal plasma and right after delivery in umbilical cord blood by ELISA assay...
January 15, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29306607/the-prevalence-and-correlates-of-frailty-in-urban-and-rural-populations-in-latin-america-china-and-india-a-10-66-population-based-survey
#3
Juan J Llibre Rodriguez, A Matthew Prina, Daisy Acosta, Mariella Guerra, Yueqin Huang, K S Jacob, Ivonne Z Jimenez-Velasquez, Aquiles Salas, Ana Luisa Sosa, Joseph D Williams, A T Jotheeswaran, Isaac Acosta, Zhaorui Liu, Martin J Prince
BACKGROUND: There have been few cross-national studies of the prevalence of the frailty phenotype conducted among low or middle income countries. We aimed to study the variation in prevalence and correlates of frailty in rural and urban sites in Latin America, India, and China. METHODS: Cross-sectional population-based catchment area surveys conducted in 8 urban and 4 rural catchment areas in 8 countries; Cuba, Dominican Republic, Puerto Rico, Venezuela, Peru, Mexico, China, and India...
January 3, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29301046/identification-of-the-alarm-pheromone-of-cowpea-aphid-and-comparison-with-two-other-aphididae-species
#4
Sandrine Mariella Bayendi Loudit, Antoine Boullis, François Verheggen, Frédéric Francis
In response to a predator attack, many Aphidinae species release an alarm pheromone, which induces dispersal behavior in other individuals within the colony. The major component of this pheromone is the sesquiterpene (E)-β-farnesene (Eβf), but variations occur between aphid species. In the present work, we collected, identified, and quantified the alarm pheromone of Aphis craccivora Koch (Hemiptera: Aphididae), before quantifying the escape behavior induced in the neighboring individuals. We compared the semiochemistry and associated behavior of alarm signaling with two other aphid species: Myzus persicae (Sulzer) (Hemiptera: Aphididae) and Aphis fabae Scopoli (Hemiptera: Aphididae)...
January 1, 2018: Journal of Insect Science
https://www.readbyqxmd.com/read/29283703/growth-of-yersinia-pseudotuberculosis-strains-at-different-temperatures-ph-values-and-nacl-and-ethanol-concentrations
#5
Riikka Keto-Timonen, Anna Pöntinen, Mariella Aalto-Araneda, Hannu Korkeala
Maximum growth temperature and growth limits in Luria-Bertani broth at different pH values and NaCl and ethanol concentrations were determined for 49 Yersinia pseudotuberculosis strains representing serotypes O:1, O:2, O:3, O:4, and O:5. In addition, the ability of the strains to grow at 0°C and the growth parameters at 1°C were determined. The maximum growth temperatures measured by Gradiplate temperature incubator varied between 42.2 and 43.7°C. All strains were able to grow at 0°C in Luria-Bertani broth within 17 days of incubation...
January 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29258191/patient-safety-in-complementary-medicine-through-the-application-of-clinical-risk-management-in-the-public-health-system
#6
Elio G Rossi, Tommaso Bellandi, Marco Picchi, Sonia Baccetti, Maria Valeria Monechi, Catia Vuono, Federica Sabatini, Antonella Traversi, Mariella Di Stefano, Fabio Firenzuoli, Sara Albolino, Riccardo Tartaglia
Aim: To develop a systematic approach to detect and prevent clinical risks in complementary medicine (CM) and increase patient safety through the analysis of activities in homeopathy and acupuncture centres in the Tuscan region using a significant event audit (SEA) and failure modes and effects analysis (FMEA). Methods: SEA is the selected tool for studying adverse events (AE) and detecting the best solutions to prevent future incidents in our Regional Healthcare Service (RHS). This requires the active participation of all the actors and external experts to validate the analysis...
December 16, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29240044/sinonasal-cancer-in-a-worker-exposed-to-chromium-in-an-unusual-industrial-sector
#7
Vera Comiati, Maria Luisa Scapellato, Enrico Alexandre, Tiziana Volo, Daniele Borsetto, Mariella Carrieri, Enzo Emanuelli, Diego Cazzador
BACKGROUND: Occupational exposure to chromium is carcinogenic for human respiratory system. Due to the low incidence of sinonasal malignancies, there is still a paucity of evidence to confirm that chromium(VI) exposure is a cause of nasal cancer. OBJECTIVES: To report on a sinonasal cancer (SNC) of rare occupational origin, increasing the awareness on epidemiological knowledge of occupational exposures to chromium compounds. METHODS: We describe a case of a 64-year-old chrome plater who worked in the galvanic industry in the early 1970s...
December 14, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29230115/interval-colorectal-cancers-at-ochsner-medical-center-where-do-we-stand
#8
Felicia Humphrey, Mariella Gastañaduy, James Smith, Charles B Whitlow
Background: An interval colorectal cancer is a cancer diagnosed prior to the recommended follow-up time from a previously negative colonoscopy. These cancers are thought to arise from a rapidly growing cancer, missed cancer, or incompletely resected adenomas. Our study aimed to identify interval cancers diagnosed during a 4-year period and to identify any potential risk factors associated with these cancers. Secondly, we compared our interval colorectal cancer rate with other published rates...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29217486/aberrant-promoter-methylation-in-genes-related-to-hematopoietic-malignancy-in-workers-exposed-to-a-voc-mixture
#9
Octavio Jiménez-Garza, Liqiong Guo, Hyang-Min Byun, Mariella Carrieri, Giovanni Battista Bartolucci, Briscia Socorro Barrón-Vivanco, Andrea A Baccarelli
Occupational exposure to volatile organic compounds (VOCs) may cause hematopoietic malignancy, either by single exposure to benzene or possibly due to a concomitant exposure to several VOCs. Since oxidative stress, inflammation and DNA repair pathways are closely involved in cancer development, the effect of VOC exposure on expression of proteins involved in these pathways has been studied, but epigenetic changes have not been well described. Here, DNA methylation status following occupational exposure to a VOC mixture was assessed by bisulfite sequencing of the promoter regions of seven genes involved in the mentioned pathways...
December 4, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29207583/autologous-transplant-for-myeloma-when-the-old-meets-the-new
#10
EDITORIAL
Francesca Gay, Mariella Genuardi, Mario Boccadoro
No abstract text is available yet for this article.
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29190908/egfr-targeted-nonviral-nis-gene-transfer-for-bioimaging-and-therapy-of-disseminated-colon-cancer-metastases
#11
Sarah Urnauer, Andrea M Müller, Christina Schug, Kathrin A Schmohl, Mariella Tutter, Nathalie Schwenk, Wolfgang Rödl, Stephan Morys, Michael Ingrisch, Jens Bertram, Peter Bartenstein, Dirk-André Clevert, Ernst Wagner, Christine Spitzweg
Liver metastases present a serious problem in the therapy of advanced colorectal cancer (CRC), as more than 20% of patients have distant metastases at the time of diagnosis with less than 5% being cured. Consequently, new therapeutic approaches are of major need together with high-resolution imaging methods that allow highly specific detection of small metastases. The unique combination of reporter and therapy gene function of the sodium iodide symporter (NIS) may represent a promising theranostic strategy for CRC liver metastases allowing non-invasive imaging of functional NIS expression and therapeutic application of 131I...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29189705/validation-of-the-italian-version-of-the-critical-pain-observation-tool-in-brain-injured-critically-ill-adults
#12
Francesco Sulla, Nilson De Souza Ramos, Noemi Terzi, Tania Trenta, Mariella Uneddu, Melanny Alessandra Zaldivar Cruces, Leopoldo Sarli
BACKGROUND AND AIM: Pain in intensive care units (ICUs) is a frequent and often undermanaged problem. Brain-injured patients are often unable to reliably self-report their pain, calling forth the need to use behavioural scales such as the Critical-Care Pain Observation Tool (CPOT). This study aimed to test the reliability and validity of the Italian CPOT use with brain-injured ICU adults. METHOD: A sample of 50 adults critical care patients was included. Each patient was assessed by two independent observers at three predefined times - at rest; during mobilization for hygiene; 20 minutes later - using the CPOT, PAINAD, and NRS...
November 30, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29177947/effect-of-lactobacillus-rhamnosus-on-the-response-of-galleria-mellonella-against-staphylococcus-aureus-and-escherichia-coli-infections
#13
Adeline Lacerda Jorjão, Felipe Eduardo de Oliveira, Mariella Vieira Pereira Leão, Antonio Olavo Cardoso Jorge, Luciane Dias de Oliveira
This study evaluated the prophylactic effects of the live or heat-killed probiotic strain Lactobacillus rhamnosus ATCC 7469 in Galleria mellonella, inoculated with Staphylococcus aureus or Escherichia coli. L. rhamnosus suspension was prepared and a part of it was autoclaved to obtain heat-killed lactobacilli. The larvae were inoculated of these suspensions and pathogenic. The survival of the larvae was observed during 7 days and after 24 h of inoculation haemocytes counted, melanization and nitric oxide production were analyzed...
November 24, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/29172149/exposure-to-deltamethrin-induces-oxidative-stress-and-decreases-of-energy-reserve-in-tissues-of-the-neotropical-fruit-eating-bat-artibeus-lituratus
#14
Jerusa Maria Oliveira, Nicole Fontes Losano, Suellen Silva Condessa, Renata Maria Pereira de Freitas, Silvia Almeida Cardoso, Mariella Bontempo Freitas, Leandro Licursi de Oliveira
Deltamethrin (DTM) is a synthetic pyrethroid insecticide highly used by farmers and home users. This pesticide has lipophilic properties that facilitate a high absorption and can cause toxicity in non-target organisms. During foraging, the fruit-eating bats Artibeus lituratus are exposed to pesticides. However, the knowledge of the toxicity of pesticides on the physiology of bats is relatively scarce. This study aimed to check the toxicity of short-term exposure to low concentration of DTM on fruit-eating bat A...
November 21, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29167974/long-term-outcome-of-vaginal-mesh-or-native-tissue-in-recurrent-prolapse-a-randomized-controlled-trial
#15
Alfredo L Milani, Anne Damoiseaux, Joanna IntHout, Kirsten B Kluivers, Mariella I J Withagen
INTRODUCTION AND HYPOTHESIS: Our aim was to evaluate clinically relevant long-term outcomes of transvaginal mesh or native tissue repair in women with recurrent pelvic organ prolapse (POP). METHODS: We performed a 7-year follow-up of a randomized controlled trial on trocar-guided mesh placement or native tissue repair in women with recurrent POP. Primary outcome was composite success, defined as absence of POP beyond the hymen, absence of bulge symptoms, and absence of retreatment for POP...
November 22, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/29160392/prevalence-and-sensitivity-of-bacilli-and-pseudomonas-in-the-newborn-s-oral-cavity
#16
Priscila Vitor Alves Ferreira, Isabela Amêndola, Luciane Dias de Oliveira, Célia Regina Gonçalves E Silva, Mariella Vieira Pereira Leão, Silvana Soléo Ferreira Dos Santos
The aim of this study was to isolate Enterobacteria and Pseudomonas from the oral cavity of hospitalized newborns (NB) and determine their prevalence and the sensitivity profile to most commonly used antibiotics for this age group. Samples from the oral cavity of NB from 24 to 48 h age were collected using swabs. The samples were inoculated on MacConkey agar, incubated and the colonies counted and identified. For each strain, the minimum inhibitory concentration (MIC) was determined using agar dilution test...
July 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29153463/late-normal-tissue-effects-in-the-arm-and-shoulder-following-lymphatic-radiotherapy-results-from-the-uk-start-standardisation-of-breast-radiotherapy-trials
#17
Joanne S Haviland, Mariella Mannino, Clare Griffin, Nuria Porta, Mark Sydenham, Judith M Bliss, John R Yarnold
BACKGROUND AND PURPOSE: Adjuvant lymphatic radiotherapy (LNRT) is recommended for selected axillary node positive women with early breast cancer. We investigated whether hypofractionated LNRT is safe combined with similarly-hypofractionated breast/chest wall radiotherapy (RT). MATERIAL AND METHODS: The Standardisation of Breast Radiotherapy (START) pilot, A and B trials randomised women with early breast cancer to schedules of 2.67-3.3 Gy versus 2.0 Gy fractions (control)...
November 15, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29136400/changes-in-bone-turnover-and-calcium-homeostasis-during-pregnancy-and-lactation-in-mammals-a-meta-analysis
#18
Diego A Torres, Mariella B Freitas, Reggiani V Gonçalves
Large amounts of calcium are required during pregnancy and lactation to support fetal and neonatal bone growth and calcification. An inadequate supply of calcium during these stages can lead to unsuccessful reproduction or impaired offspring fitness. During reproduction, female mammals undergo numerous physiological changes, including adaptations to allow an adequate supply of calcium. The lack of quantitative studies analysing these physiological changes from a comparative perspective limits our ability to explain and understand these adaptations...
November 15, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29108288/baseline-factors-associated-with-response-to-ruxolitinib-an-independent-study-on-408-patients-with-myelofibrosis
#19
Francesca Palandri, Giuseppe Alberto Palumbo, Massimiliano Bonifacio, Mario Tiribelli, Giulia Benevolo, Bruno Martino, Elisabetta Abruzzese, Mariella D'Adda, Nicola Polverelli, Micaela Bergamaschi, Alessia Tieghi, Francesco Cavazzini, Adalberto Ibatici, Monica Crugnola, Costanza Bosi, Roberto Latagliata, Ambra Di Veroli, Luigi Scaffidi, Federico de Marchi, Elisa Cerqui, Barbara Anaclerico, Giovanna De Matteis, Marco Spinsanti, Elena Sabattini, Lucia Catani, Franco Aversa, Francesco Di Raimondo, Umberto Vitolo, Roberto Massimo Lemoli, Renato Fanin, Francesco Merli, Domenico Russo, Antonio Cuneo, Maria Letizia Bacchi Reggiani, Michele Cavo, Nicola Vianelli, Massimo Breccia
In patients with Myelofibrosis (MF) treated with ruxolitinib (RUX), the response is unpredictable at therapy start. We retrospectively evaluated the impact of clinical/laboratory factors on responses in 408 patients treated with RUX according to prescribing obligations in 18 Italian Hematology Centers. At 6 months, 114 out of 327 (34.9%) evaluable patients achieved a spleen response. By multivariable Cox proportional hazard regression model, pre-treatment factors negatively correlating with spleen response were: high/intermediate-2 IPSS risk (p=0...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29104933/heat-resistance-mediated-by-plm58-plasmid-borne-clpl-in-listeria-monocytogenes
#20
Anna Pöntinen, Mariella Aalto-Araneda, Miia Lindström, Hannu Korkeala
Listeria monocytogenes is one of the most heat-resistant non-spore-forming food-borne pathogens and poses a notable risk to food safety, particularly when mild heat treatments are used in food processing and preparation. While general heat stress properties and response mechanisms of L. monocytogenes have been described, accessory mechanisms providing particular L. monocytogenes strains with the advantage of enhanced heat resistance are unknown. Here, we report plasmid-mediated heat resistance of L. monocytogenes for the first time...
November 2017: MSphere
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