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Mariella G Filbin, Dominik Sturm
Gliomas are the most common primary central nervous system (CNS) neoplasms in children and adolescents and are thought to arise from their glial progenitors or stem cells. Although the exact cells of origin for most pediatric gliomas remain to be identified, our current understanding is that specific cell populations during CNS development are susceptible to particular oncogenic events during certain time windows and thus give rise to pediatric gliomas with distinct histological, molecular, and clinical features...
February 2018: Seminars in Neurology
Jole Mariella, Eleonora Iacono, Aliai Lanci, Barbara Merlo, Caterina Palermo, Lee Morris, Carolina Castagnetti
The umbilical cord (UC), the connection between mother and fetus via the umbilical vessels, carries nutrients and oxygenated blood to the fetus through the umbilical vein and removes deoxygenated blood and waste products via the umbilical arteries. It is designed to protect blood flow to the fetus during pregnancy. In equine medicine, only a few studies have described the UC, and most of these involved Thoroughbreds. The present study describes and compares the macroscopic features of the equine umbilical cord in three different breeds and in relation to the foal's gender...
March 7, 2018: Theriogenology
Maria K van de Waarsenburg, Nienke E van Hoogenhuijze, Anique T M Grob, Karlijn J Schweitzer, Mariëlla I J Withagen, Carl H van der Vaart
INTRODUCTION AND HYPOTHESIS: Internal closure of the urethral sphincter is one of the mechanisms in maintaining continence. Little is known about changes in the urethral sphincter during pregnancy. We designed this study to develop a reliable method to measure the area and mean echogenicity of the midurethra during and after pregnancy and to assess changes over time. METHODS: Two observers independently segmented the urethra as follows: in the sagittal plane, the urethra was positioned vertically, the marker was placed in the middle section of the lumen of the urethra, and eight tomographic US images of 2...
March 12, 2018: International Urogynecology Journal
Umberto Capasso Palmiero, Lavinia Morosi, Ezia Bello, Marianna Ponzo, Roberta Frapolli, Cristina Matteo, Mariella Ferrari, Massimo Zucchetti, Lucia Minoli, Marcella De Maglie, Pierpaolo Romanelli, Massimo Morbidelli, Maurizio D'Incalci, Davide Moscatelli
The improvement of the pharmacological profile of lipophilic drug formulations is one of the main successes achieved using nanoparticles (NPs) in medicine. However, the complex synthesis procedure and numerous post-processing steps hamper the cost-effective use of these formulations. In this work, an approach which requires only a syringe to produce self-assembling biodegradable and biocompatible poly(caprolactone)-based NPs is developed. The effective synthesis of monodisperse NPs has been made possible by the optimization of the block copolymer synthesized via a combination of ring opening polymerization and reversible addition-fragmentation chain transfer polymerization...
March 7, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Bruno Vincenzi, Giuseppe Badalamenti, Grazia Armento, Marianna Silletta, Mariella Spalato Ceruso, Giovanna Catania, Andrea Napolitano, Giuseppa Maltese, Sergio Valeri, Lorena Incorvaia, Daniele Santini, Giuseppe Tonini
OBJECTIVES: Low body mass index (BMI) and/or low lean body mass have been shown to be risk factors for chemotherapy-related toxicities in a number of different cancers. However, no data are available regarding the role of BMI as a risk factor for developing toxicities related to the novel anticancer agent, trabectedin, in patients with soft-tissue sarcoma (STS). We evaluated the role of BMI as a risk factor for trabectedin-related toxicity in patients with STS. METHODS: Data from 51 patients with metastatic/advanced STS treated with trabectedin after progression on ≥1 anthracycline ± ifosfamide regimen were retrospectively reviewed...
March 6, 2018: Oncology
Fabio Efficace, Fausto Castagnetti, Bruno Martino, Massimo Breccia, Mariella D'Adda, Emanuele Angelucci, Fabio Stagno, Francesco Cottone, Alessandra Malato, Elena Trabacchi, Silvana Franca Capalbo, Marco Gobbi, Giuseppe Visani, Marzia Salvucci, Isabella Capodanno, Patrizia Tosi, Mario Tiribelli, Anna Rita Scortechini, Luciano Levato, Elena Maino, Gianni Binotto, Gabriele Gugliotta, Marco Vignetti, Michele Baccarani, Gianantonio Rosti
BACKGROUND: Although a wealth of efficacy and safety data is available for many tyrosine kinase inhibitors used in chronic myeloid leukemia (CML), there is a dearth of information on their impact on patients' health-related quality of life (HRQOL). The primary objective of this study was to evaluate HRQOL and fatigue outcomes in patients with CML receiving first-line therapy with nilotinib. METHODS: This was a multicenter, prospective study enrolling 130 patients with chronic-phase CML...
March 2, 2018: Cancer
Laura Freije-Carrelo, Laura Alonso Sobrado, Mariella Moldovan, Jorge Ruiz Encinar, Jose Ignacio Garcia-Alonso
Dissolved inorganic carbon (DIC) is one of the most important parameters to be measured in seawaters for climate change studies. Its quantitative assessment requires analytical methodologies with overall uncertainties around 0.05% RSD for clear evaluation of temporal trends. Herein, two alternative Isotope Dilution Mass Spectrometry (IDMS) methodologies (on-line and species-specific) using an Isotope Ratio Mass Spectrometer (IRMS) and two calculation procedures for each methodology have been compared. As a result, a new method for the determination of DIC in seawaters, based on species-specific IDMS with Isotope Pattern Deconvolution calculation, was developed and validated...
March 2, 2018: Analytical Chemistry
Martin J Prince, Daisy Acosta, Mariella Guerra, Yueqin Huang, Ivonne Z Jimenez-Velazquez, Juan J Llibre Rodriguez, Aquiles Salas, Ana Luisa Sosa, Kia-Chong Chua, Michael E Dewey, Zhaorui Liu, Rosie Mayston, Adolfo Valhuerdi
BACKGROUND: Exposure to endogenous estrogen may protect against dementia, but evidence remains equivocal. Such effects may be assessed more precisely in settings where exogenous estrogen administration is rare. We aimed to determine whether reproductive period (menarche to menopause), and other indicators of endogenous estrogen exposure are inversely associated with dementia incidence. METHODS: Population-based cohort studies of women aged 65 years and over in urban sites in Cuba, Dominican Republic, Puerto Rico and Venezuela, and rural and urban sites in Peru, Mexico and China...
2018: PloS One
Paige M Kulling, Kristine C Olson, Cait E Hamele, Mariella F Toro, Su-Fern Tan, David J Feith, Thomas P Loughran
T cell large granular lymphocyte leukemia (T-LGLL) is a rare incurable disease that is characterized by defective apoptosis of cytotoxic CD8+ T cells. Chronic activation of the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway is a hallmark of T-LGLL. One manifestation is the constitutive phosphorylation of tyrosine 701 of STAT1 (p-STAT1). T-LGLL patients also exhibit elevated serum levels of the STAT1 activator, interferon-γ (IFN-γ), thus contributing to an inflammatory environment...
2018: PloS One
Alberto L Abbate, Doron Tolomeo, Ingrid Cifola, Marco Severgnini, Antonella Turchiano, Bartolomeo Augello, Gabriella Squeo, Pietro D Addabbo, Debora Traversa, Giulia Daniele, Angelo Lonoce, Mariella Pafundi, Massimo Carella, Orazio Palumbo, Anna Dolnik, Dominique Muehlematter, Jacqueline Schoumans, Nadine Van Roy, Gianluca De Bellis, Giovanni Martinelli, Giuseppe Merla, Lars Bullinger, Claudia Haferlach, Clelia Tiziana Storlazzi
Double minutes (dmin), homogeneously staining regions, and ring chromosomes are vehicles of gene amplification in cancer. The underlying mechanism leading to their formation as well as their structure and function in acute myeloid leukemia (AML) remain mysterious. We combined a range of high-resolution genomic methods to investigate the architecture and expression pattern of amplicons involving chromosome band 8q24 in 23 cases of AML (AML-amp). This revealed that different MYC-dmin architectures can coexist within the same leukemic cell population, indicating a step-wise evolution rather than a single event origin, such as through chromothripsis...
February 22, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Inês Gomes Ferreira, Michela Pucci, Giulia Venturi, Nadia Malagolini, Mariella Chiricolo, Fabio Dall'Olio
Glycosylation is a very frequent and functionally important post-translational protein modification that undergoes profound changes in cancer. Growth and death factor receptors and plasma membrane glycoproteins, which upon activation by extracellular ligands trigger a signal transduction cascade, are targets of several molecular anti-cancer drugs. In this review, we provide a thorough picture of the mechanisms bywhich glycosylation affects the activity of growth and death factor receptors in normal and pathological conditions...
February 15, 2018: International Journal of Molecular Sciences
Valentina Nairi, Silvia Magnolia, Marco Piludu, Mariella Nieddu, Cristian Antonio Caria, Valeria Sogos, Maria Vallet-Regì, Maura Monduzzi, Andrea Salis
Mesoporous silica nanoparticles (MSNs) were functionalized with amino groups (MSN-NH2 ) and then with hyaluronic acid, a biocompatible biopolymer which can be recognized by CD44 receptors in tumor cells, to obtain a targeting drug delivery system. To this purpose, three hyaluronic acid samples differing for the molecular weight, namely HAS (8-15 kDa), HAM (30-50 kDa) and HAL (90-130 kDa), were used. The MSN-HAS , MSN-HAM , and MSN-HAL materials were characterized through zeta potential and dynamic light scattering measurements at pH = 7...
February 12, 2018: Colloids and Surfaces. B, Biointerfaces
Paulo F Severino, Mariana Silva, Mylene Carrascal, Nadia Malagolini, Mariella Chiricolo, Giulia Venturi, Roberto Barbaro Forleo, Annalisa Astolfi, Mariangela Catera, Paula A Videira, Fabio Dall'Olio
BACKGROUND: Treatment with Bacillus Calmette-Guérin (BCG) is the gold standard adjuvant immunotherapy of non-muscle invasive bladder cancer (NMIBC), although it fails in one third of the patients. NMIBC expresses two tumor-associated O-linked carbohydrates: the disaccharide (Galβ1,3GalNAc) Thomsen-Friedenreich (T) antigen, and its sialylated counterpart (Siaα2,3Galβ1,3GalNAc) sialyl-T (sT), synthesized by sialyltransferase ST3GAL1, whose roles in BCG response are unknown. METHODS: The human bladder cancer (BC) cell line HT1376 strongly expressing the T antigen, was retrovirally transduced with the ST3GAL1 cDNA or with an empty vector, yielding the cell lines HT1376sT and HT1376T , that express, respectively, either the sT or the T antigens...
February 17, 2018: BMC Cancer
Giovanni Scandale, Gabriel Dimitrov, Martino Recchia, Gianni Carzaniga, Marzio Minola, Edoardo Perilli, Maria Carotta, Mariella Catalano
Arterial stiffening is a hallmark of the aging process and atherosclerosis, including peripheral arterial disease (PAD). We investigated the associations between carotid-femoral pulse wave velocity (c-fPWV), augmentation index corrected for heart rate (Aix@HR75), ankle brachial index (ABI), and subendocardial viability ratio (SEVR), an indicator of cardiac perfusion. The c-fPWV, Aix@HR75, and SEVR was estimated using applanation tonometry. The ankle systolic pressure measurements for the calculation of the ABI were obtained using an 8-mHz Doppler probe...
February 15, 2018: Journal of Clinical Hypertension
Margaret Mariella, Charles W Kimbrough, Kelly M McMasters, Nicolas Ajkay
Time interval (TI) from breast cancer diagnosis to definitive surgery is increasing, but the impact on outcomes is not well understood. TI longer than 30 days is associated with a greater chance of delay of chemotherapy, which may impact survival. We sought to identify factors associated with longer TI and the influence on outcome measures. METHODS: We examined TI for stage 0-III breast cancer patients treated between 2006 and 2015 at a university-based cancer center. Univariate and multivariate analyses were used to study factors associated with TI <30, 30 to 60, and >60 days...
January 1, 2018: American Surgeon
Laurent Garderet, Simona Iacobelli, Linda Koster, Hartmut Goldschmidt, Jan-Erik Johansson, Jean Henri Bourhis, Marta Krejci, Xavier Leleu, Michael Potter, Didier Blaise, Christian Koenecke, Christian Peschel, Jakub Radocha, Bernd Metzner, Pascal Lenain, Kerstin Schäfer-Eckart, David Pohlreich, Mariella Grasso, Denis Caillot, Herman Einsele, Marco Ladetto, Stefan Schönland, Nicolaus Kröger
OBJECTIVES: To evaluate the outcome of a salvage third autologous stem cell transplantation (ASCT) in relapsed multiple myeloma. PATIENTS AND METHODS: We analyzed 570 patients who had received a third ASCT between 1997 and 2010 (EBMT data), of whom 482 patients had received tandem ASCT and a third ASCT at first relapse (AARA group) and 88 patients had an upfront ASCT with second and third transplants after subsequent relapses (ARARA group). RESULTS: With a median follow-up of 61 and 48 months after salvage third ASCT, the day 100 non-relapse mortality was 4% and 7%, the incidence of second primary malignancy was 6% and 7%, the median progression free survival was 13 and 8 months and median overall survival (OS) was 33 and 15 months (AARA and ARARA groups, respectively)...
February 2, 2018: Biology of Blood and Marrow Transplantation
Mariella Vieira Pereira Leão, Talita Angelina Aureliano Tavares, Célia Regina Gonçalves E Silva, Silvana Soleo Ferreira Dos Santos, Juliana Campos Junqueira, Luciane Dias de Oliveira, Antonio Olavo Cardoso Jorge
OBJECTIVE: This study aimed to investigate the influence of Lactobacillus rhamnosus intake on the development of candidiasis and cytokines release. MATERIAL AND METHODS: Candida suspensions were inoculated into the oral cavity of experimentally immunosuppressed mice for candidiasis induction. The animals were divided into experimental groups: candidiasis with no probiotic intake (F), candidiasis with probiotic intake during Candida inoculation (FP), and candidiasis with probiotic intake 14 days before inoculation with Candida (FPP); and control groups: (C), (CP), and (CPP) without inducing candidiasis with probiotic intake in the same manner as groups F, FP, and FPP, respectively...
January 25, 2018: Clinical Oral Investigations
Navkiran Kalsi, Renata Tambelli, Daniela Altavilla, Cristina Trentini, Sara Panunzi, Mariella Stanca, Paola Aceto, Francesco Cardona, Carlo Lai
OBJECTIVES: The present study investigated the role of different emotions in the expression of cognitive and motor control abilities of children having Tourette's Syndrome (TS) compared to healthy controls. METHODS: The electroencephalography (EEG) activity of thirty-three children (mean age in final sample: TS (n = 10)=10.5±2.3; control (n = 10)=10.1±2.9) was recorded during a visual task consisting of four emotional face cues (anger, happiness, neutral and sadness) followed by a target in congruent or incongruent position with emotional cue...
January 24, 2018: World Journal of Biological Psychiatry
Mona D Doshi, Mariella Ortigosa-Goggins, Amit X Garg, Lihua Li, Emilio D Poggio, Cheryl A Winkler, Jeffrey B Kopp
Black living kidney donors are at higher risk of developing kidney disease than white donors. We examined the effect of the APOL1 high-risk genotype on postdonation renal function in black living kidney donors and evaluated whether this genotype alters the association between donation and donor outcome. We grouped 136 black living kidney donors as APOL1 high-risk (two risk alleles; n =19; 14%) or low-risk (one or zero risk alleles; n =117; 86%) genotype. Predonation characteristics were similar between groups, except for lower mean±SD baseline eGFR (CKD-EPI equation) in donors with the APOL1 high-risk genotype (98±17 versus 108±20 ml/min per 1...
January 16, 2018: Journal of the American Society of Nephrology: JASN
Marie Franz, Mariella Polterauer, Stephanie Springer, Lorenz Kuessel, Peter Haslinger, Christof Worda, Katharina Worda
PURPOSE: To evaluate the effect of gestational diabetes on omentin-1 in maternal and cord plasma. As a potent mediator of insulin resistance, Omentin-1, an adipokine derived from human adipose and placental tissue, may be an important player in the pathophysiology of gestational diabetes. METHODS: This was a prospective case-control study. The study included 96 women with gestational diabetes and 96 pregnant women without. Omentin-1 was measured at the time of the oral glucose tolerance test, at 32 weeks in maternal plasma and right after delivery in umbilical cord blood by ELISA assay...
January 15, 2018: Archives of Gynecology and Obstetrics
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