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https://www.readbyqxmd.com/read/29790423/improved-cost-effectiveness-and-blood-product-utilization-from-instituting-a-blood-ordering-algorithm-for-cardiac-surgical-cases
#1
Kelly Ural, Jay Trusheim, Yamah Amiri, Mariella Gastañaduy
BACKGROUND: Results of a previous study revealed an over-ordering of blood products for cardiac surgery and led to the creation of a new blood ordering algorithm. This follow-up study has been conducted to evaluate improvement in ordering practices. METHODS: Retrospective data were collected for 171 patients who underwent coronary artery bypass grafting or valve surgery from March 2015 to March 2016 to determine the crossmatch-to-transfusion ratio (C:tx) and potential cost savings...
May 1, 2018: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29770124/does-family-history-of-obesity-cardiovascular-and-metabolic-diseases-influence-onset-and-severity-of-childhood-obesity
#2
Domenico Corica, Tommaso Aversa, Mariella Valenzise, Maria Francesca Messina, Angela Alibrandi, Filippo De Luca, Malgorzata Wasniewska
Objectives: The objectives were to evaluate (1) the metabolic profile and cardiometabolic risk in overweight/obese children at first assessment, stratifying patients according to severity of overweight and age; and (2) to investigate the relationship between family history (FH) for obesity and cardiometabolic diseases and severity of childhood obesity. Methods: In this cross-sectional, retrospective, observational study, 260 children (139 female), aged between 2...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29753637/safety-and-efficacy-of-cabozantinib-in-metastatic-renal-cell-carcinoma-real-world-data-from-an-italian-managed-access-program
#3
Giuseppe Procopio, Michele Prisciandaro, Roberto Iacovelli, Enrico Cortesi, Giuseppe Fornarini, Gaetano Facchini, Giacomo Cartenì, Roberto Sabbatini, Gabriella Del Bene, Luca Galli, Claudia Caserta, Andrea Giovanni Multari, Marco Bregni, Francesco Massari, Sebastiano Buti, Ugo De Giorgi, Fable Zustovich, Michele Milella, Fabio Calabrò, Maria Laura Mancini, Giampaolo Tortora, Claudio Vernieri, Daniele Santini, Mariella Sorarù, Riccardo Ricotta, Cristina Masini, Marcello Tucci, Stefano Luzi Fedeli, Cinzia Ortega, Antonella Mecozzi, Raffaele Ratta, Cora N Sternberg, Elena Verzoni
BACKGROUND: The randomized phase 3 METEOR study confirmed a survival benefit of cabozantinib over everolimus in patients with metastatic renal-cell carcinoma (mRCC) with disease that progressed after treatment with at least one previous antiangiogenic inhibitor. The aim of this analysis was to evaluate the safety and activity of cabozantinib in an unselected population. METHODS: Data were collected across 24 Italian centers. Cabozantinib therapy was initiated at physician request between September and December 2016...
April 19, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29746869/seroprevalence-of-taenia-solium-antibodies-in-a-cohort-of-bolivian-immigrants-in-italy
#4
Andrea Angheben, Dora Buonfrate, Lorenzo Zammarchi, Marianne Strohmeyer, Federico Gobbi, Monica Degani, Mariella Anselmi, Valentina Marchese, Alessandro Bartoloni, Zeno Bisoffi
We conducted a retrospective study aimed at estimating the seroprevalence of anti-cysticercus antibodies in a Bolivian community settled in Italy. Seroprevalence of 9% was found, testing 495 sera with immunoblot. This study contributes to outline the epidemiological scenario of cysticercosis in immigrants living in Europe.
May 7, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29739680/alkalinization-with-potassium-bicarbonate-improves-glutathione-status-and-protein-kinetics-in-young-volunteers-during-21-day-bed-rest
#5
Gianni Biolo, Filippo Giorgio Di Girolamo, Martina Heer, Mariella Sturma, Sara Mazzucco, Francesco Agostini, Roberta Situlin, Pierandrea Vinci, Mauro Giordano, Judith Buehlmeier, Petra Frings-Meuthen, Filippo Mearelli, Nicola Fiotti
BACKGROUND & AIMS: Physical inactivity is associated with lean body mass wasting, oxidative stress and pro-inflammatory changes of cell membrane lipids. Alkalinization may potentially counteract these alterations. We evaluated the effects of potassium bicarbonate supplementation on protein kinetics, glutathione status and pro- and anti-inflammatory polyunsaturated fatty acids (PUFA) in erythrocyte membranes in humans, during experimental bed rest. METHODS: Healthy, young, male volunteers were investigated at the end of two 21-day bed rest periods, one with, and the other without, daily potassium bicarbonate supplementation (90 mmol × d-1 ), according to a cross-over design...
April 12, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29700168/phase-i-study-of-the-heparanase-inhibitor-roneparstat-an-innovative-approach-for-multiple-myeloma-therapy
#6
Monica Galli, Manik Chatterjee, Mariella Grasso, Giorgina Specchia, Hila Magen, Hermann Einsele, Ivana Celeghini, Paola Barbieri, David Paoletti, Silvia Pace, Ralph D Sanderson, Alessandro Rambaldi, Arnon Nagler
No abstract text is available yet for this article.
April 26, 2018: Haematologica
https://www.readbyqxmd.com/read/29686397/influence-of-age-on-histologic-outcome-of-cervical-intraepithelial-neoplasia-during-observational-management-results-from-large-cohort-systematic-review-meta-analysis
#7
Christine Bekos, Richard Schwameis, Georg Heinze, Marina Gärner, Christoph Grimm, Elmar Joura, Reinhard Horvat, Stephan Polterauer, Mariella Polterauer
Aim of this study was to investigate the histologic outcome of cervical intraepithelial neoplasia (CIN) during observational management. Consecutive women with histologically verified CIN and observational management were included. Histologic findings of initial and follow-up visits were collected and persistence, progression and regression rates at end of observational period were assessed. Uni- and multivariate analyses were performed. A systematic review of the literature and meta-analysis was performed...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674595/developmental-and-oncogenic-programs-in-h3k27m-gliomas-dissected-by-single-cell-rna-seq
#8
Mariella G Filbin, Itay Tirosh, Volker Hovestadt, McKenzie L Shaw, Leah E Escalante, Nathan D Mathewson, Cyril Neftel, Nelli Frank, Kristine Pelton, Christine M Hebert, Christine Haberler, Keren Yizhak, Johannes Gojo, Kristof Egervari, Christopher Mount, Peter van Galen, Dennis M Bonal, Quang-De Nguyen, Alexander Beck, Claire Sinai, Thomas Czech, Christian Dorfer, Liliana Goumnerova, Cinzia Lavarino, Angel M Carcaboso, Jaume Mora, Ravindra Mylvaganam, Christina C Luo, Andreas Peyrl, Mara Popović, Amedeo Azizi, Tracy T Batchelor, Matthew P Frosch, Maria Martinez-Lage, Mark W Kieran, Pratiti Bandopadhayay, Rameen Beroukhim, Gerhard Fritsch, Gad Getz, Orit Rozenblatt-Rosen, Kai W Wucherpfennig, David N Louis, Michelle Monje, Irene Slavc, Keith L Ligon, Todd R Golub, Aviv Regev, Bradley E Bernstein, Mario L Suvà
Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of the central nervous system of young children, suggesting a cooperation between genetics and cellular context in tumorigenesis. Although the genetics of H3K27M-glioma are well characterized, their cellular architecture remains uncharted. We performed single-cell RNA sequencing in 3321 cells from six primary H3K27M-glioma and matched models. We found that H3K27M-glioma primarily contain cells that resemble oligodendrocyte precursor cells (OPC-like), whereas more differentiated malignant cells are a minority...
April 20, 2018: Science
https://www.readbyqxmd.com/read/29661830/sustained-adrenergic-signaling-promotes-intratumoral-innervation-through-bdnf-induction
#9
Julie K Allen, Guillermo N Armaiz-Pena, Archana S Nagaraja, Nouara C Sadaoui, Tatiana Ortiz, Robert Dood, Merve Ozcan, Danielle M Herder, Monika Haemerrle, Kshipra M Gharpure, Rajesha Rupaimoole, Rebecca Previs, Sherry Y Wu, Sunila Pradeep, Xiaoyun Xu, Hee Dong Han, Behrouz Zand, Heather J Dalton, Morgan Taylor, Wei Hu, Justin Bottsford-Miller, Myrthala Moreno-Smith, Yu Kang, Lingegowda S Mangala, Cristian Rodriguez-Aguayo, Vasudha Sehgal, Erika L Spaeth, Prahlad T Ram, Stephen Tc Wong, Frank C Marini, Gabriel Lopez-Berestein, Steve W Cole, Susan K Lutgendorf, Mariella diBiasi, Anil K Sood
Mounting clinical and preclinical evidence supports a key role for sustained adrenergic signaling in the tumor microenvironment as a driver of tumor growth and progression. However, the mechanisms by which adrenergic neurotransmitters are delivered to the tumor microenvironment are not well understood. Here we present evidence for a feedforward loop whereby adrenergic signaling leads to increased tumoral innervation. In response to catecholamines, tumor cells produced brain-derived neurotrophic factor (BDNF) in an ADRB3/cAMP/Epac/JNK-dependent manner...
April 16, 2018: Cancer Research
https://www.readbyqxmd.com/read/29652896/a-cohort-study-of-the-effects-of-older-adult-care-dependence-upon-household-economic-functioning-in-peru-mexico-and-china
#10
Maëlenn M Guerchet, Mariella Guerra, Yueqin Huang, Peter Lloyd-Sherlock, Ana Luisa Sosa, Richard Uwakwe, Isaac Acosta, Peter Ezeah, Sara Gallardo, Zhaorui Liu, Rosie Mayston, Veronica Montes de Oca, Hong Wang, Martin J Prince
BACKGROUND: While links between disability and poverty are well established, there have been few longitudinal studies to clarify direction of causality, particularly among older adults in low and middle income countries. We aimed to study the effect of care dependence among older adult residents on the economic functioning of their households, in catchment area survey sites in Peru, Mexico and China. METHODS: Households were classified from the evolution of the needs for care of older residents, over two previous community surveys, as 'incident care', 'chronic care' or 'no care', and followed up three years later to ascertain economic outcomes (household income, consumption, economic strain, satisfaction with economic circumstances, healthcare expenditure and residents giving up work or education to care)...
2018: PloS One
https://www.readbyqxmd.com/read/29652654/patients-with-juvenile-idiopathic-arthritis-become-adults-the-role-of-transitional-care
#11
REVIEW
Fabrizio Conti, Irene Pontikaki, Mariella D'Andrea, Angelo Ravelli, Fabrizio De Benedetti
Most juvenile idiopathic arthritis (JIA) patients need to attend adult rheumatology centres to continue the clinical management of their disease and to receive adequate long-term treatment. Transition from the paediatric to the adult health care team is a critical moment in the clinical history of these patients, but unfortunately, about 50% of the transfer processes to adult rheumatology are not successful, putting these patients at high risk of unfavourable outcomes. There are several obstacles to the success of transitional care for JIA patients, such as the absence of specific criteria for the assessment of disease activity, the lack of specific treatment recommendations for JIA adult patients, the poor adolescent-specific training for adult rheumatologists, and the shortage of resources...
April 13, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29649337/leg-length-skull-circumference-and-the-incidence-of-dementia-in-latin-america-and-china-a-10-66-population-based-cohort-study
#12
Martin J Prince, Daisy Acosta, Mariella Guerra, Yueqin Huang, Ivonne Z Jimenez-Velazquez, Juan J Llibre Rodriguez, Aquiles Salas, Ana Luisa Sosa, Michael E Dewey, Maelenn M Guerchet, Zhaorui Liu, Jorge J Llibre Guerra, A Matthew Prina
BACKGROUND: Adult leg length is influenced by nutrition in the first few years of life. Adult head circumference is an indicator of brain growth. Cross-sectional studies indicate inverse associations with dementia risk, but there have been few prospective studies. METHODS: Population-based cohort studies in urban sites in Cuba, Dominican Republic Puerto Rico and Venezuela, and rural and urban sites in Peru, Mexico and China. Sociodemographic and risk factor questionnaires were administered to all participants, and anthropometric measures taken, with ascertainment of incident dementia, and mortality, three to five years later...
2018: PloS One
https://www.readbyqxmd.com/read/29624703/epidemiology-outcome-and-risk-factors-for-infectious-complications-in-myelofibrosis-patients-receiving-ruxolitinib-a-multicenter-study-on-446-patients
#13
Nicola Polverelli, Giuseppe A Palumbo, Gianni Binotto, Elisabetta Abruzzese, Giulia Benevolo, Micaela Bergamaschi, Alessia Tieghi, Massimiliano Bonifacio, Massimo Breccia, Lucia Catani, Mario Tiribelli, Mariella D'Adda, Nicola Sgherza, Alessandro Isidori, Francesco Cavazzini, Bruno Martino, Roberto Latagliata, Monica Crugnola, Florian Heidel, Costanza Bosi, Adalberto Ibatici, Francesco Soci, Domenico Penna, Luigi Scaffidi, Franco Aversa, Roberto M Lemoli, Umberto Vitolo, Antonio Cuneo, Domenico Russo, Michele Cavo, Nicola Vianelli, Francesca Palandri
Infections represent one of the major concerns regarding the utilization of ruxolitinib (RUX) in patients with myelofibrosis. With the aim to investigate epidemiology, outcome and risk factors for infections in RUX-exposed patients, we collected clinical and laboratory data of 446 myelofibrosis patients treated with RUX between June 2011 and November 2016 in 23 European Hematology Centers. After a median RUX exposure of 23.5 months (range, 1-56), 123 patients (28%) experienced 161 infectious events (grades 3-4 32%, fatal 9%), for an incidence rate of 17 cases per 100 pts/y...
April 6, 2018: Hematological Oncology
https://www.readbyqxmd.com/read/29594972/a-pharmacological-rationale-to-reduce-the-incidence-of-opioid-induced-tolerance-and-hyperalgesia-a-review
#14
REVIEW
Giustino Varrassi, Mariella Fusco, Stephen D Skaper, Daniele Battelli, Panagiotis Zis, Stefano Coaccioli, Maria Caterina Pace, Antonella Paladini
Chronic pain is an important health and social problem. Misuse and abuse of opioids in chronic non-cancer pain management seem to be a huge problem, in some countries. This could probably affect the normal use of such analgesics in patients in need of them. Basic and clinical researches should find the solution to mitigate the potential damage. Dysregulation of mast cell and microglia activation plays an important role in the pathogenesis and management of chronic pain. Persistent mast cell activation sensitizes nociceptors and initiates central nervous system inflammatory processes, involving microglial cell activation and sensitization of spinal somatosensory neurons...
March 28, 2018: Pain and Therapy
https://www.readbyqxmd.com/read/29567768/highly-sensitive-myd88-l265p-mutation-detection-by-droplet-digital-pcr-in-waldenstr%C3%A3-m-macroglobulinemia
#15
Daniela Drandi, Elisa Genuardi, Irene Dogliotti, Martina Ferrante, Cristina Jiménez, Francesca Guerrini, Mariella Lo Schirico, Barbara Mantoan, Vittorio Muccio, Giuseppe Lia, Gian Maria Zaccaria, Paola Omedè, Roberto Passera, Lorella Orsucci, Giulia Benevolo, Federica Cavallo, Sara Galimberti, Ramón García-Sanz, Mario Boccadoro, Marco Ladetto, Simone Ferrero
We here describe a novel method for MYD88L265P mutation detection and minimal residual disease monitoring in Waldenström Macroglobulinemia, by droplet digital PCR, in bone marrow and peripheral blood cells, as well as in circulating cell free DNA. Our method shows a sensitivity of 5.00E-05, by far superior to the widely used allele-specific polymerase chain reaction (1.00E-03). Overall, 291 unsorted samples from 148 patients (133 Waldenstrom 11 IgG-lymphoplasmacytic lymphoma and 4 IgM-monoclonal gammopathy of undetermined significance), 194 baseline and 97 follow-up, were analyzed...
March 22, 2018: Haematologica
https://www.readbyqxmd.com/read/29560505/non-obstetrical-indications-for-cesarean-section-a-state-of-the-art-review
#16
REVIEW
Roberta Venturella, Paola Quaresima, Mariella Micieli, Erika Rania, Annarita Palumbo, Federica Visconti, Fulvio Zullo, Costantino Di Carlo
PURPOSE: To propose an evidence-based review on the most frequent indications for Cesarean section (CS) given by specialists in disciplines other than Obstetrics and Gynecology, with the aim of increasing consciousness about the available data in the literature and the guidelines recommendations about topics that are not frequently managed by obstetricians and gynecologists. METHODS: We analyzed hospital discharge data regarding deliveries occurred in a 10-year study period in our department to obtain the prevalence and the list of the most recurrent non-obstetrical indications for CS...
March 20, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29558771/relationships-friendships-and-successful-social-communication-addressing-disability
#17
Amy L Donaldson, Mariella Nolfo, Marissa Montejano
Children with autism may perceive friendship in a qualitatively different manner than their neurotypical peers. Yet, these friendships have been reported as satisfying to the child with autism spectrum disorder (ASD). Although many studies have identified lower quality of friendship in ASD, reduced reciprocity, and increased loneliness and depression, perhaps it is time to take a closer look at the perspective of autistic individuals and to identify how the broader community influences development of relationships and friendship...
April 2018: Seminars in Speech and Language
https://www.readbyqxmd.com/read/29556207/non-verbal-cognitive-abilities-in-children-and-adolescents-affected-by-migraine-and-tension-type-headache-an-observational-study-using-the-leiter-3
#18
Lucia Margari, Roberto Palumbi, Paola A Lecce, Francesco Craig, Marta Simone, Mariella Margari, Silvana M C Seccia, Maura Buttiglione
Headache is one of the most common neurological disorders in developmental age. Several studies investigated the relationship between headache and emotional/behavioral problems. We studied non-verbal cognitive abilities, including non-verbal memory and attention skills, in order to evaluate the impact of primary headache on these domains. The latest version of the cognitive battery Leiter International Performance Scale - Third Edition (Leiter-3), a non-verbal test, was administered to 35 children and adolescents affected by migraine or tension-type headache and to 23 healthy subjects...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29551322/brazilian-portuguese-translation-cross-cultural-adaptation-and-reproducibility-assessment-of-the-modified-bristol-stool-form-scale-for-children
#19
Debora Rodrigues Jozala, Isabelle Stefan de Faria Oliveira, Erika Veruska Paiva Ortolan, Wilson Elias de Oliveira Junior, Giovana Tuccille Comes, Vanessa Mello Granado Cassettari, Mariella Marie Self, Pedro Luiz Toledo de Arruda Lourenção
OBJECTIVE: To translate and culturally adapt the modified Bristol Stool Form Scale for children into Brazilian Portuguese, and to evaluate the reproducibility of the translated version. METHODS: The stage of translation and cross-cultural adaptation was performed according to an internationally accepted methodology, including the translation, back-translation, and pretest application of the translated version to a sample of 74 children to evaluate the degree of understanding...
March 15, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29548059/gliomas-in-children
#20
Mariella G Filbin, Dominik Sturm
Gliomas are the most common primary central nervous system (CNS) neoplasms in children and adolescents and are thought to arise from their glial progenitors or stem cells. Although the exact cells of origin for most pediatric gliomas remain to be identified, our current understanding is that specific cell populations during CNS development are susceptible to particular oncogenic events during certain time windows and thus give rise to pediatric gliomas with distinct histological, molecular, and clinical features...
February 2018: Seminars in Neurology
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