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Zheyi Dong, Yuanda Wang, Qiang Qiu, Xueguang Zhang, Li Zhang, Jie Wu, Ribao Wei, Hanyu Zhu, Guangyan Cai, Xuefeng Sun, Xiangmei Chen
AIMS: Non-diabetic renal diseases (NDRDs) are associated with better renal outcomes than diabetic nephropathy (DN). This study was conducted to determine the common clinical markers predicting NDRDs in type 2 diabetes patients. METHODS: Patients with type 2 diabetes mellitus who underwent a renal biopsy were screened. Eligible patients were categorized into two groups: DN group and NDRD group. Patient's clinical characteristics and laboratory data were collected...
September 21, 2016: Diabetes Research and Clinical Practice
Yael Einbinder, Debbie J Goodman, Isabelle Haggiag, Tania Zahavi, Sydney Benchetrit
BACKGROUND: Kidney biopsies are not routinely performed for diabetic patients with chronic kidney disease. However in some cases, a biopsy is carried out to exclude other treatable Prolonged duration of diabetes, insulin therapies and presence of diabetic retinopathy were associated with a greater likelihood of DN. The high prevalence of NDRD in our population emphasizes the judicious use of kidney biopsy in diabetic patients. e renal diseases. The prevalence and the nature of non diabetic renal disease (NDRD) among diabetic patients in Israel have not yet been evaluated...
March 2016: Harefuah
Shujun Liu, Qiaoyan Guo, Hongbo Han, Peihe Cui, Xiao Liu, Lining Miao, Hongbin Zou, Guangdong Sun
OBJECTIVE: To investigate the clinical and histopathological features of non-diabetic renal disease (NDRD) superimposed on diabetic nephropathy (DN) in northeastern Chinese patients with type 2 diabetes mellitus (T2D), and compare the changes with those of pure DN and isolated NDRD. METHODS: Single-center retrospective analysis based on medical records of 273 patients (172 men, mean age: 51.1 ± 12.4 years) with T2D who underwent renal biopsy between February 2000 and October 2015...
October 2016: International Urology and Nephrology
Marco Fiorentino, Davide Bolignano, Vladimir Tesar, Anna Pisano, Wim Van Biesen, Giovanni Tripepi, Graziella D'Arrigo, Loreto Gesualdo
BACKGROUND: The utility of renal biopsy in patients with diabetes is highly debated. Diabetics with rapidly worsening renal disease are often 'clinically' labelled as having diabetic nephropathy (DN), whereas, in many cases, they are rather developing a non-diabetic renal disease (NDRD) or mixed forms (DN + NDRD). METHODS: We performed a systematic search for studies on patients with diabetes with data on the frequency of DN, NDRD and mixed forms, and assessed the positive predictive values (PPVs) and odds ratios (ORs) for such diagnoses by meta-analysing single-study prevalence...
May 4, 2016: Nephrology, Dialysis, Transplantation
Ali Nayer, Gargi Davda, Rima Pai, Luis M Ortega
BACKGROUND: Approximately one-third of individuals with type 2 diabetes mellitus will eventually develop diabetic nephropathy (DN). Impaired renal function in type 2 diabetics may also be secondary to non-diabetic renal disease (NDRD). NDRD in type 2 diabetics may occur alone in the absence of DN or may be superimposed on DN. Renal biopsy maybe indicated to establish the correct diagnosis and to ascertain the severity of glomerular and tubulointerstitial pathology. CASE: We report a patient with type 2 diabetes mellitus and chronic renal insufficiency who developed worsening of renal function in the setting of staphylococcal infection and antibiotic use...
2016: Journal of Renal Injury Prevention
Malgorzata Wągrowska-Danilewicz, Marian Danilewicz
This is the first report from Poland documenting biopsy-proven renal diseases in type 2 diabetes mellitus. We analyzed the data of 76 patients with type 2 diabetes who underwent renal biopsy and were diagnosed in the Department of Nephropathology, Medical University of Lodz. The patients were divided into the following three groups according to the histological diagnosis: group I - isolated non-diabetic renal disease (NDRD); group II - NDRD superimposed on underlying diabetic nephropathy (NDRD + DN); and group III - isolated diabetic nephropathy (DN)...
December 2015: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
J Prakash, T Gupta, S Prakash, P Bhushan, Usha, M Sivasankar, S P Singh
Diabetic nephropathy (DN) has become the leading cause of end-stage renal disease worldwide. Non-diabetic renal disease (NDRD), is known to occur in diabetic patients. The renal and retinal relationship in type 2 diabetes mellitus (T2DM) with nephropathy is not uniform. This study was carried to study the histological spectrum of nephropathy in type 2 diabetic patients with proteinuria and its relationship with diabetic retinopathy (DR). Total 31 (males - 26; females - 5) proteinuric type 2 diabetic patients were studied...
July 2015: Indian Journal of Nephrology
Shuang-Tong Yan, Jun-Yan Liu, Hui Tian, Chun-Lin Li, Jian Li, Ying-Hong Shao, Huai-Yin Shi, Yu Liu, Yan-Ping Gong, Fu-Sheng Fang, Ban-Ruo Sun
The aim of this study was to investigate the causes and influential factors of renal damage in elderly patients with type 2 diabetes mellitus (T2DM). Clinical data and pathological findings at autopsy of 161 elderly T2DM patients died between October 1994 and August 2011 were retrospectively reviewed. The mean age of these patients was 80.8 ± 8.3 years (range 60-105 years). The incidences of diabetic nephropathy (DN), non-diabetic renal diseases (NDRD), and DN complicated with NDRD were 31.1, 62.7, and 16...
August 2016: Clinical and Experimental Medicine
Tayebeh Soleymanian, Gholamreza Hamid, Mohammad Arefi, Iraj Najafi, Mohammad Reza Ganji, Manuchehr Amini, Monirosadat Hakemi, Mohammad Reza Mohajeri Tehrani, Bagher Larijani
BACKGROUND: Renal involvement in type 2 diabetes is mostly due to diabetic nephropathy (DN), but a subset of diabetic patients could present with pure non-diabetic renal disease (NDRD) or NDRD superimposed on DN. We conducted a prospective cohort study to identify the underline renal pathology in type 2 diabetic patients with defined clinical criteria for renal biopsy. METHODS: A total of 46 patients (27 female, mean age of 48.9 ± 11.9 years) with type 2 diabetes mellitus (DM) and atypical features of DN with unexpected proteinuria, hematuria, and/or renal impairment were enrolled in this study...
May 2015: Renal Failure
Maria Pallayova, Azharuddin Mohammed, Gerald Langman, Shahrad Taheri, Indranil Dasgupta
AIMS: The indications for renal biopsy in type 2 diabetes mellitus (T2D) are not well established. We investigated the prevalence, spectrum, and predictors of biopsy-proven non-diabetic renal disease (NDRD) in T2D. METHODS: An observational, single-center, retrospective study of T2D adults who underwent renal biopsies (N = 51) over 10 years for nephrotic-range proteinuria, microscopic hematuria, or rapidly declining renal function. RESULTS: Thirty-five (68...
July 2015: Journal of Diabetes and its Complications
Viera Železníková, Marcela Vedralová, Anna Kotrbová-Kozak, Hana Zoubková, Marie Černá, Ivan Rychlík
BACKGROUND/AIMS: Calcium-Sensing Receptor (CaSR) significantly affects calcium-phosphate metabolism in kidneys, and it is implicated in the pathogenesis of diabetes mellitus (DM) due to its expression in pancreatic β-cells. The role of CaSR as one of the players in pathogenesis of chronic kidney disease (CKD) has been speculated. METHODS: 158 Type 2 diabetic patients divided into three groups according to occurrence and type of kidney complications, 66 nondiabetic patients CKD, and 93 healthy subjects were enrolled into the study to analyze the role of two CaSR polymorphisms (in the codon 990 and in the intron 4) in ethiopathogenesis of DM and CKD...
2014: Kidney & Blood Pressure Research
L Jonathan Zwi, Theodora S Y Yiu, Mark R Marshall, Michael K Lam-Po-Tang
The aims of this study were to identify non-diabetic renal disease (NDRD), including obesity related glomerulopathy (ORG) in diabetic patients, and compare the findings with those of pure diabetic nephropathy (DN).Ninety-three renal biopsies from diabetic patients were reviewed retrospectively, along with their clinical findings at biopsy and their estimated glomerular filtration rate (eGFR) over 5 years follow-up. DN and focal segmental glomerulosclerosis (FSGS) were diagnosed on blinded histology review, together with assessment of renal compartment histology...
August 2014: Pathology
Devadass Clement Wilfred, Vijaya Viswanath Mysorekar, Raju S Venkataramana, Mahesh Eshwarappa, Revathi Subramanyan
BACKGROUND: The prevalence of nondiabetic renal disease (NDRD) among type 2 diabetics varies widely depending on the populations being studied and the selection criteria. Also, for patients found to have NDRD different predicting factors have been identified by different studies. OBJECTIVES: TO DETERMINE: (i) Frequency and spectrum of NDRD in type 2 diabetics with atypical clinical renal disease, in our set up and (ii) common clinical markers that are associated with NDRD in our local population...
July 2013: Journal of Laboratory Physicians
Mo-yan Liu, Xiang-mei Chen, Xue-feng Sun, Jian-hui Zhou, Xue-guang Zhang, Han-yu Zhu, Yi-zhi Chen, Shu-wen Liu, Ri-bao Wei, Li Tang, Guang-yan Cai, Li Zhang, Xue-yuan Bai
BACKGROUND: The aims of the present study were to validate the differential diagnostic model of diabetic nephropathy (DN) and non-diabetic renal diseases (NDRD) established in 2003 and to establish a new diagnostic model suitable for the current clinical characteristics of DN. METHODS: We examined 200 patients with Type 2 diabetes who underwent kidney biopsy from 2004 to 2012. The 2003 differential diagnostic model based on the data collected from 1993 to 2003 was evaluated by the diagnostic test and changes in the clinical differentiation parameters of DN and NDRD were analyzed...
November 2014: Journal of Diabetes
Jai Prakash
In contrast to Type 1 diabetes mellitus (DM), the incidence of non-diabetic renal disease (NDRD) is very high in Type 2 diabetic patients. A wide spectrum of non-diabetic nephropathy (NDN) including both glomerular and tubulointerstitial lesions are reported in patients with Type 2 DM and their precise diagnosis requires histological examination of kidney tissue. Renal biopsy studies suggest that 25-50% of patients with Type 2 diabetes had glomerular lesions unrelated to or in addition to diabetic nephropathy...
March 2013: Journal of the Association of Physicians of India
Maria L Gonzalez Suarez, David B Thomas, Laura Barisoni, Alessia Fornoni
Diabetic nephropathy (DN) is one of the most important long-term complications of diabetes. Patients with diabetes and chronic kidney disease have an increased risk of all-cause mortality, cardiovascular mortality, and kidney failure. The clinical diagnosis of DN depends on the detection of microalbuminuria. This usually occurs after the first five years from the onset of diabetes, and predictors of DN development and progression are being studied but are not yet implemented into clinical practice. Diagnostic tests are useful tools to recognize onset, progression and response to therapeutic interventions...
December 15, 2013: World Journal of Diabetes
Ja Min Byun, Cheol Hyun Lee, Sul Ra Lee, Ju Young Moon, Sang Ho Lee, Tae Won Lee, Chun Gyoo Ihm, Kyung Hwan Jeong
BACKGROUND/AIMS: In several recent studies, renal biopsies in patients with type 2 diabetes and renal disease have revealed a heterogeneous group of disease entities. Our aim was to study the prognosis and clinical course of nondiabetic renal disease (NDRD) and to determine risk factors for NDRD in patients with type 2 diabetes. METHODS: Renal biopsy reports of 110 patients with type 2 diabetes who were seen at Kyung Hee University Medical Center and Kyung Hee University Hospital at Gangdong, Seoul, Korea between January 2000 and December 2011 were retrospectively analyzed...
September 2013: Korean Journal of Internal Medicine
Shree G Sharma, Andrew S Bomback, Jai Radhakrishnan, Leal C Herlitz, Michael B Stokes, Glen S Markowitz, Vivette D D'Agati
BACKGROUND AND OBJECTIVES: Renal biopsies performed in diabetic patients are increasing in number and complexity. This study sought to determine the usefulness of renal biopsy in patients with diabetes and the predictability of diagnosing diabetic nephropathy (DN) versus nondiabetic renal disease (NDRD) from clinical and laboratory data. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: To assess modern trends, a retrospective study was performed of clinical-pathologic findings in all patients with diabetes who had a biopsy in 2011...
October 2013: Clinical Journal of the American Society of Nephrology: CJASN
Shuang Liang, Xue-Guang Zhang, Guang-Yan Cai, Han-Yu Zhu, Jian-Hui Zhou, Jie Wu, Pu Chen, Shu-Peng Lin, Qiang Qiu, Xiang-Mei Chen
BACKGROUND: Renal injuries in patients with diabetes include diabetic nephropathy (DN) and non-diabetic renal diseases (NDRD). The value of a clinical diagnosis of DN and NDRD remains inconclusive. We conducted a meta-analysis of the literature to identify predictive factors of NDRD and to compare the clinical characteristics of DN and NDRD for differential diagnosis. METHODS: We searched PubMed (1990 to January 2012), Embase (1990 to February 2009), and CNKI (1990 to January 2012) to identify studies that enrolled patients with DN and NDRD...
2013: PloS One
Li Zhuo, Guming Zou, Wenge Li, Jianhua Lu, Wenwen Ren
BACKGROUND: The incidence of diabetes mellitus (DM) and diabetic nephropathy (DN) have risen rapidly in the past few decades and have become an economic burden to the healthcare system in China. DN is a major complication of DM and is a leading cause of end-stage renal disease (ESRD). The occurrence of non-diabetic renal disease (NDRD) in diabetic patients has been increasingly recognized in recent years. It is generally believed that it is difficult to reverse DN, whereas some cases of NDRD are readily treatable and remittable...
2013: European Journal of Medical Research
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