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non-diabetic renal disease

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https://www.readbyqxmd.com/read/29924846/prevalence-of-diabetic-retinopathy-and-diabetic-macular-edema-in-a-primary-care-based-teleophthalmology-program-for-american-indians-and-alaskan-natives
#1
Sven-Erik Bursell, Stephanie J Fonda, Drew G Lewis, Mark B Horton
BACKGROUND: Diabetes and its complications are more common in American Indians and Alaska Natives (AI/AN) than other US racial/ethnic populations. Prior reports of diabetic retinopathy (DR) prevalence in AI/AN are dated, and research on diabetic macular edema (DME) is limited. This study characterizes the recent prevalence of DR and DME in AI/AN using primary care-based teleophthalmology surveillance. METHODS: This is a multi-site, clinic-based, cross-sectional study of DR and DME...
2018: PloS One
https://www.readbyqxmd.com/read/29923339/cardiovascular-disease-in-diabetes-type-2-current-concepts
#2
REVIEW
A Rosengren
Type 2 diabetes is a major and accelerating public health challenge. Between 1980 and 2014, a period of just 35 years, the number of adults with diabetes globally is estimated to have increased from 108 million to 422 million, due not only to sharply rising obesity rates, but also to increasing population size, and longer life expectancy. The increase in numbers is due to an increasing prevalence of diabetes worldwide, increasing population size, and longer life expectancy. Overall, worldwide age-standardized adult diabetes prevalence doubled from 4...
June 20, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29915661/multifactorial-aetiology-for-non-uremic-calciphylaxis-a-case-report
#3
Sijan Basnet, Niranjan Tachamo, Rashmi Dhital, Biswaraj Tharu
Calciphylaxis is commonly associated with end-stage renal disease patients on haemodialysis. We present a rare case of calciphylaxis in a non-uremic patient. The diagnosis was made clinically and confirmed with skin biopsy showing calcification of the dermal and subcutaneous tissues in the von Kossa stain. We believe that the combination of uncontrolled diabetes mellitus, a non-functioning paraganglioma and vitamin D deficiency in a susceptible female patient was responsible for causing calciphylaxis in our patient...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29913174/low-dose-aspirin-is-associated-with-reduced-spontaneous-preterm-birth-in-nulliparous-women
#4
Maria Andrikopoulou, Stephanie E Purisch, Roxane Handal-Orefice, Cynthia Gyamfi-Bannerman
BACKGROUND: Preterm birth (PTB) is one of the leading causes of perinatal morbidity and mortality. Clinical data suggests that low dose aspirin may decrease the rate of overall PTB, but investigators have speculated that this is likely due to a decrease in medically indicated PTB through its effect on the incidence of preeclampsia and other placental disease. We hypothesized that low dose aspirin may also impact the mechanism of spontaneous preterm labor. OBJECTIVE: Our objective was to determine whether low dose aspirin reduces the rate of spontaneous PTB in nulliparous women without medical co-morbidities...
June 15, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29910771/use-of-readily-accessible-inflammatory-markers-to-predict-diabetic-kidney-disease
#5
REVIEW
Lauren Winter, Lydia A Wong, George Jerums, Jas-Mine Seah, Michele Clarke, Sih Min Tan, Melinda T Coughlan, Richard J MacIsaac, Elif I Ekinci
Diabetic kidney disease is a common complication of type 1 and type 2 diabetes and is the primary cause of end-stage renal disease in developed countries. Early detection of diabetic kidney disease will facilitate early intervention aimed at reducing the rate of progression to end-stage renal disease. Diabetic kidney disease has been traditionally classified based on the presence of albuminuria. More recently estimated glomerular filtration rate has also been incorporated into the staging of diabetic kidney disease...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29910024/dulaglutide-versus-insulin-glargine-in-patients-with-type-2-diabetes-and-moderate-to-severe-chronic-kidney-disease-award-7-a-multicentre-open-label-randomised-trial
#6
Katherine R Tuttle, Mark C Lakshmanan, Brian Rayner, Robert S Busch, Alan G Zimmermann, D Bradley Woodward, Fady T Botros
BACKGROUND: Many antihyperglycaemic drugs, including insulin, are primarily cleared by the kidneys, restricting treatment options for patients with kidney disease. Dulaglutide is a long-acting glucagon-like peptide-1 receptor agonist that is not cleared by the kidneys, and confers a lower risk of hypoglycaemia than does insulin. We assessed the efficacy and safety of dulaglutide in patients with type 2 diabetes and moderate-to-severe chronic kidney disease. METHODS: AWARD-7 was a multicentre, open-label trial done at 99 sites in nine countries...
June 14, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29906583/prevalence-incidence-co-morbidity-and-mortality-rates-of-ossification-of-posterior-longitudinal-ligament-opll-in-the-cervical-spine-a-nested-case-control-cohort-study
#7
Bong Ju Moon, Sun Kyu Choi, Dong Ah Shin, Seong Yi, Keung Nyun Kim, Do Heum Yoon, Yoon Ha
OBJECT: To evaluate the prevalence, incidence, morbidity, and mortality rates of cervical ossification of posterior longitudinal ligament (OPLL), using data from a 12-year national cohort of 1,025,340 Korean people. METHODS: A nested case-control cohort study was performed using the insurance claims database, during 2002 to 2013, provided by the National Health Insurance Service. We examined the prevalence and incidence of cervical OPLL. Age/sex-matched controls were randomly extracted, with 10 times the number of OPLL cases...
June 12, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29906428/effects-of-coffee-intake-on-incident-chronic-kidney-disease-community-based-prospective-cohort-study
#8
Jong Hyun Jhee, Ki Heon Nam, Seong Yeong An, Min-Uk Cha, Misol Lee, Seohyun Park, Hyoungnae Kim, Hae-Ryong Yun, Youn Kyung Kee, Jung Tak Park, Tae-Ik Chang, Ea Wha Kang, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han
BACKGROUND: Drinking coffee can raise public health problems, but the association between coffee and kidney disease is unknown. We studied whether coffee intake can affect the development of chronic kidney disease in the general population. METHODS: We analyzed 8717 subjects with normal renal function recruited from the KoGES cohort. Based on food frequency questionnaire, coffee consumption was categorized into five groups: 0/week, <1 cup/week, 1-6 cups/week, 1 cup/day, and ≥2 cups/day...
June 12, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29904118/psoriasis-risk-in-patients-with-diabetic-retinopathy-a-nationwide-population-based-study
#9
Ji Hyun Lee, Ju Hee Han, Kyung Do Han, Young Min Park, Jun Young Lee, Yong-Gyu Park, Young Bok Lee
Psoriasis is a chronic cutaneous disease known to be related with systemic disease; however, the association between psoriasis and diabetic complications has not been previously reported. Diabetic microvascular complications include diabetic retinopathy (DR), nephropathy, and neuropathy, and overt diabetic nephropathy can lead to the end-stage renal disease (ESRD).The present study investigated the association between psoriasis and non-proliferative DR (NPDR) or proliferative DR (PDR) or ESRD. We analyzed the relationship between diabetic complication and psoriasis using data from the National Health Insurance Service between 2009 and 2015...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29901095/loss-of-klf15-accelerates-chronic-podocyte-injury
#10
Seung Seok Han, Mi-Yeon Yu, Kyung Don Yoo, Jung Pyo Lee, Dong Ki Kim, Yon Su Kim, Seung Hee Yang
Krüppel‑like factor 15 (KLF15), also known as kidney‑enriched transcription factor, is known to participate in podocyte differentiation. However, the role of KLF15 in chronic podocyte injury remains incompletely understood, particularly in proteinuric disease models. In the present study, the 5/6 nephrectomy mouse model was used to induce chronic podocyte injury. Human primary podocytes were isolated by flow cytometry and cultured to emulate the injury process in an in vitro system. Biopsied kidney tissue samples were obtained from patients with primary membranous nephropathy or diabetic nephropathy in order to analyze the relationship between glomerular KLF15 expression and subsequent outcomes...
June 11, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29897845/renal-mitochondrial-oxidative-stress-is-enhanced-by-the-reduction-of-sirt3-activity-in-zucker-diabetic-fatty-rats
#11
Yoshio Ogura, Munehiro Kitada, Itaru Monno, Keizo Kanasaki, Ai Watanabe, Daisuke Koya
OBJECTIVES: Mitochondrial oxidative stress is involved in the pathogenesis of diabetic kidney disease. The objective of our study is to identify the mechanisms of renal mitochondrial oxidative stress, focusing on Sirt3, which is nicotinamide adenine dinucleotide (NAD+ ; oxidized NAD)-dependent deacetylase in mitochondria. METHODS: Renal mitochondrial oxidative stress and Sirt3 activity, using Zucker diabetic fatty rats (ZDFRs) and cultured proximal tubular cells under high-glucose condition were evaluated...
December 2018: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/29897281/autophagy-activation-in-circulating-proangiogenic-cells-pacs-aggravates-aki-in-type-i-diabetes-mellitus
#12
Katrin Schwarze, Andreas Kribben, Oliver Ritter, Gerhard A Müller, Daniel Patschan
BACKGROUND: AKI (Acute Kidney Injury) occurs frequently in hospitals worldwide, the therapeutic options are limited. Diabetes mellitus (DM) affects more and more people around the globe, the disease worsens the prognosis of AKI even further. In recent years, cell-based therapies have increasingly been applied in experimental AKI. Aim of the study was to utilize two established autophagy inducers for pharmacological preconditioning of so-called proangiogenic cells (PACs) in PAC treatment of diabetic AKI...
June 13, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29890958/anemia-and-mortality-in-patients-with-nondialysis-dependent-chronic-kidney-disease
#13
Heide A Stirnadel-Farrant, Jiacong Luo, Lata Kler, Borut Cizman, Delyth Jones, Steven M Brunelli, Alexander R Cobitz
BACKGROUND: A combination of safety concerns and labeling changes impacted use of erythropoiesis-stimulating agents (ESAs) in renal anemia. Data regarding contemporary utilization in pre-dialysis chronic kidney disease (CKD) are lacking. METHODS: Electronic healthcare records and medical claims data of pre-dialysis CKD patients were aggregated from a large US managed care provider (2011-13). ESA use patterns, characteristics, and outcomes of ESA-treated/untreated patients were quantified...
June 11, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29889287/association-between-sickle-cell-trait-with-selected-chronic-medical-conditions-in-u-s-service-members
#14
David W Niebuhr, Ligong Chen, Stephanie Shao, Jonathan Goldsmith, Celia Byrne, Darrell E Singer
Introduction: Sickle cell trait (SCT), the heterozygous carrier state for hemoglobin S, is present in an estimated 1.6% of all newborns and 7.3% in black individuals in the USA. SCT has long been considered a benign condition with anticipated normal life expectancy and no increased risk for chronic diseases. The medical literature is inconclusive on the potential association between SCT and chronic medical conditions (CMC) including chronic kidney disease, venous thromboembolism, and stroke...
June 8, 2018: Military Medicine
https://www.readbyqxmd.com/read/29887266/intracellular-organelles-in-health-and-kidney-disease
#15
Fateme Shamekhi Amiri
Subcellular organelles consist of smaller substructures called supramolecular assemblies and these in turn consist of macromolecules. Various subcellular organelles have critical functions that consist of genetic disorders of organelle biogenesis and several metabolic disturbances that occur during non-genetic diseases e.g. infection, intoxication and drug treatments. Mitochondrial damage can cause renal dysfunction as ischemic acute renal injury, chronic kidney disease progression. Moreover, mitochondrial dysfunction is an early event in aldosterone-induced podocyte injury and cardiovascular disease due to oxidative stress in chronic kidney disease...
June 7, 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29883668/age-rage-axis-blockade-in-diabetic-nephropathy-current-status-and-future-directions
#16
REVIEW
Davoud Sanajou, Amir Ghorbani Haghjo, Hassan Argani, Somayeh Aslani
Diabetic nephropathy is one of the most frequent micro-vascular complications both in type 1 and type 2 diabetic patients and is the leading cause of end-stage renal disease worldwide. Although disparate mechanisms give rise to the development of diabetic nephropathy, prevailing evidence accentuates that hyperglycemia-associated generation of advanced glycation end products (AGEs) plays a central role in the disease pathophysiology. Engagement of the receptor for AGE (RAGE) with its ligands provokes oxidative stress and chronic inflammation in renal tissues, ending up with losses in kidney function...
June 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29881185/electromagnetic-simulation-of-non-invasive-approach-for-the-diagnosis-of-diabetic-foot-ulcers
#17
Roshen Borkar, James Rizkalla, Youngmin Kwon, Paul Salama, Maher Rizkalla
Diabetic foot ulcers are systemic diseases that affect all blood vessels within the human body. From major blood vessels to microvasculature, hardening, thickening, and narrowing of blood vessels ultimately results to diminished blood flow to end organs. The detrimental effects of peripheral vascular disease are well recognized across medicine, particularly with regards to diabetic foot ulcers. Diabetic foot ulcers (DFU) are common across all fields of medicine, including but not limited to: orthopedics, vascular surgery, podiatry, general internal medicine, and infectious disease...
June 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29871909/probing-insulin-sensitivity-in-diabetic-kidney-disease-is-there-a-stronger-role-for-functional-imaging
#18
REVIEW
Michael L Granda, Pooja Amarapurkar, Alessia Fornoni
Clinical and experimental evidence support a cause-effect relationship between altered insulin signaling and development of kidney disease of metabolic and non-metabolic origin. However, the current criteria to measure and/or estimate the insulin resistance (IR) are available as research tool but are very difficult to implement in the clinical practice. Therefore, a better understanding of the key players contributing to IR may lead to the development of new non-invasive tools to assess organ-specific insulin sensitivity (IS)...
June 14, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29868775/frailty-body-composition-and-the-risk-of-mortality-in-incident-hemodialysis-patients-the-predictors-of-arrhythmic-and-cardiovascular-risk-in-end-stage-renal-disease-study
#19
Jessica Fitzpatrick, Stephen M Sozio, Bernard G Jaar, Michelle M Estrella, Dorry L Segev, Rulan S Parekh, Mara A McAdams-DeMarco
Background: Frail obese community-dwelling older adults are at increased mortality risk. Among hemodialysis (HD) patients, frailty is common and associated with increased mortality risk; however, in dialysis, obesity is associated with decreased mortality risk. Whether the frail-obese phenotype is associated with increased mortality risk among HD patients remains unclear. Methods: This study included 370 incident HD patients enrolled in the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) study...
June 4, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29861276/asymptomatic-st-elevation-myocardial-infarction
#20
Kenton L Anderson, Neel A Shah, Moises Gallegos, I-Hui Chiang
BACKGROUND: A 71-year-old non-smoking female with a history of diabetes, hypertension, hyperlipidemia and end-stage renal disease presented to the emergency department for right leg pain due to an ankle fracture. CASE: The patient's initial electrocardiogram (ECG) revealed ST segment elevations in the anterior leads. She denied any chest pain, shortness of breath, fatigue, lightheadedness, palpitations, nausea or diaphoresis. Her initial laboratory Troponin I resulted 35...
May 31, 2018: Heart & Lung: the Journal of Critical Care
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