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https://www.readbyqxmd.com/read/28724718/poor-reliability-and-poor-adherence-to-self-monitoring-of-blood-glucose-are-common-in-women-with-gestational-diabetes-mellitus-and-may-be-associated-with-poor-pregnancy-outcomes
#1
Emmanuel Cosson, Baz Baz, Françoise Gary, Isabelle Pharisien, Minh Tuan Nguyen, Dorian Sandre-Banon, Yahya Jaber, Camille Cussac-Pillegand, Isabela Banu, Lionel Carbillon, Paul Valensi
OBJECTIVE: To evaluate the compliance with self-monitoring of blood glucose (SMBG) and the reliability of diabetes logbooks in women with gestational diabetes mellitus (GDM), as well as the associated determinants and outcomes. RESEARCH DESIGN AND METHODS: We prospectively selected French-speaking women with newly diagnosed GDM who had been referred to our diabetes management program and understood SMBG principles. At the next follow-up visit, we collected SMBG results from glucose meters and logbooks...
July 19, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28698167/use-of-a-connected-glucose-meter-and-certified-diabetes-educator-coaching-to-decrease-the-likelihood-of-abnormal-blood-glucose-excursions-the-livongo-for-diabetes-program
#2
Janelle Downing, Jenna Bollyky, Jennifer Schneider
BACKGROUND: The Livongo for Diabetes Program offers members (1) a cellular technology-enabled, two-way messaging device that measures blood glucose (BG), centrally stores the glucose data, and delivers messages back to the individual in real time; (2) unlimited BG test strips; and (3) access to a diabetes coaching team for questions, goal setting, and automated support for abnormal glucose excursions. The program is sponsored by at-risk self-insured employers, health plans and provider organizations where it is free to members with diabetes or it is available directly to the person with diabetes where they cover the cost...
July 11, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28683148/demonstration-of-disinfection-procedure-for-the-development-of-accurate-blood-glucose-meters-in-accordance-with-iso-15197-2013
#3
Shu-Ping Lin, Wen-Ye Lin, Jung-Tzu Chang, Chun-Feng Chu
Despite measures to reduce disease transmission, a risk can occur when blood glucose meters (BGMs) are used on multiple individuals or by caregivers assisting a patient. The laboratory and in-clinic performance of a BGM system before and after disinfection should be demonstrated to guarantee accurate readings and reliable control of blood glucose (BG) for patients. In this study, an effective disinfection procedure, conducting wiping 10 times to assure a one minute contact time of the disinfectant on contaminated surface, was first demonstrated using test samples of the meter housing materials, including acrylonitrile butadiene styrene (ABS), polymethyl methacrylate (PMMA), and polycarbonate (PC), in accordance with ISO 15197:2013...
2017: PloS One
https://www.readbyqxmd.com/read/28656301/involvement-of-exogenous-3%C3%A2-deoxyglucosone-in-%C3%AE-%C3%A2-cell-dysfunction-induces-impaired-glucose-regulation
#4
Lurong Zhang, Liang Zhou, Xiudao Song, Guoqiang Liang, Zhongrui Xu, Fei Wang, Fei Huang, Guorong Jiang
β‑cell dysfunction is the primary cause of type 2 diabetes mellitus (T2DM). 1,2‑dicarbonyl compounds, such as 3‑deoxyglucosone (3DG) have been reported to increase the risk of T2DM. Abnormal elevation of plasma 3DG may impair β‑cell function and thereby, it is linked to T2DM. Previous findings suggest that exogenous 3DG may serve an important role in the development of pre‑diabetes. In the present study, the authors examine whether exogenous 3DG induces impaired glucose regulation in mice by decreasing β‑cell function involving of accumulation of plasma 3DG...
June 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28647947/continuous-glucose-monitoring-in-pediatrics-the-gap-between-potential-benefits-and-the-reality-of-utility
#5
Regina L Taddeo, Joanne T Moser, Pantea P Minnock
Continuous Glucose Monitoring (CGM) is rapidly becoming a standard of care in the management of Type 1 diabetes (T1D). Today's devices are nearly as accurate as home glucose meters. They provide glucose data every 5 minutes, alert to high and low blood glucose levels, and allow for remote monitoring of a user's glucose data and patterns. Use of CGM has many benefits including support for tighter glycemic control without increasing the risk for hypoglycemia. There is however emerging evidence of some negative aspects associated with using CGM, which may result in decreased utilization of the device as well as a decline in quality of life, especially in the pediatric population...
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28640025/performance-of-a-modern-glucose-meter-in-icu-and-general-hospital-inpatients-3-years-of-real-world-paired-meter-and-central-laboratory-results
#6
Ray Zhang, Warren Isakow, Marin H Kollef, Mitchell G Scott
OBJECTIVE: Due to accuracy concerns, the Food and Drug Administration issued guidances to manufacturers that resulted in Center for Medicare and Medicaid Services stating that the use of meters in critically ill patients is "off-label" and constitutes "high complexity" testing. This is causing significant workflow problems in ICUs nationally. We wished to determine whether real-world accuracy of modern glucose meters is worse in ICU patients compared with non-ICU inpatients. DESIGN: We reviewed glucose results over the preceding 3 years, comparing results from paired glucose meter and central laboratory tests performed within 60 minutes of each other in ICU versus non-ICU settings...
June 21, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28626983/comparison-of-systemic-pharmacodynamic-effects-of-two-combination-pressurised-metered-dose-inhalers-that-deliver-salmeterol-and-fluticasone-propionate
#7
Lester I Harrison, Victoria Sessions, Christopher J Wiggenhorn, David Chalmers, Pui Leung, John Efthimiou
AIM: The aim was to test the systemic pharmacodynamic effects of the salmeterol component of two pressurized metered dose inhalers that delivered a combination of salmeterol and fluticasone propionate (SM/FP). METHODS: This was a six-way crossover study in 43 adult subjects, using a single blind design (subject blinded to product and clinical assessor blinded for all measurements). Each subject received single doses of 2, 6, and 12 inhalations from test and reference products that delivered SM/FP as 25/125 mcg per inhalation...
June 19, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28617624/how-satisfied-are-patients-when-their-choice-of-funded-glucose-meter-is-restricted-to-a-single-brand
#8
Christy Macdonald, Helen Lunt, Michelle Downie, Deborah Kendall
BACKGROUND: Many governments and insurers are driving down the cost of medical devices, including glucose meters, by the central management of purchasing decisions. We report patients' responses to an "enforced" change in brand of glucose meter, one year after the introduction of a national sole supplier arrangement for funded glucose meters and strips. METHOD: Specialist diabetes clinic attendees from two geographical locations completed a questionnaire one year after the final meter changeover date...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28617617/accuracy-and-user-performance-evaluation-of-a-new-wireless-enabled-blood-glucose-monitoring-system-that-links-to-a-smart-mobile-device
#9
Timothy S Bailey, Jane F Wallace, Scott Pardo, Mary Ellen Warchal-Windham, Bern Harrison, Robert Morin, Mark Christiansen
BACKGROUND: The new Contour(®)Plus ONE blood glucose monitoring system (BGMS) features an easy-to-use, wireless-enabled blood glucose meter that links to a smart mobile device via Bluetooth(®) connectivity and can sync with the Contour(™) Diabetes app on a smartphone or tablet. METHODS: The accuracy of the new BGMS was assessed in 2 studies according to ISO 15197:2013 criteria. In Study 1 (laboratory study), fingertip capillary blood samples from 100 subjects were tested in duplicate using 3 test strip lots...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28611921/adherence-of-self-monitoring-of-blood-glucose-in-persons-with-type-1-diabetes-in-sweden
#10
Peter Moström, Elsa Ahlén, Henrik Imberg, Per-Olof Hansson, Marcus Lind
OBJECTIVE: The primary aim was to evaluate the extent to which persons with type 1 diabetes perform self-monitoring of blood glucose (SMBG) according to guidelines. Secondary objectives were to investigate predictors for good SMBG adherence, reasons for non-adherence, and association between SMBG frequency and hemoglobin A1c (HbA1c). METHODS: This was a survey-based cross-sectional study. Questionnaires were sent out to 600 random patients at five sites. Patients were included if they were diagnosed with type 1 diabetes and ≥18 years old and excluded if they were currently using continuous glucose monitoring (CGM)...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28601891/effect-of-liraglutide-treatment-on-prediabetes-and-overweight-or-obesity-in-clozapine-or-olanzapine-treated-patients-with-schizophrenia-spectrum-disorder-a-randomized-clinical-trial
#11
RANDOMIZED CONTROLLED TRIAL
Julie R Larsen, Louise Vedtofte, Mathilde S L Jakobsen, Hans R Jespersen, Michelle I Jakobsen, Camilla K Svensson, Kamuran Koyuncu, Ole Schjerning, Peter S Oturai, Andreas Kjaer, Jimmi Nielsen, Jens J Holst, Claus T Ekstrøm, Christoph U Correll, Tina Vilsbøll, Anders Fink-Jensen
Importance: Compared with the general population, patients with schizophrenia have a 2- to 3-fold higher mortality rate primarily caused by cardiovascular disease. Previous interventions designed to counteract antipsychotic-induced weight gain and cardiometabolic disturbances reported limited effects. Objectives: To determine the effects of the glucagon-like peptide-1 receptor agonist liraglutide added to clozapine or olanzapine treatment of schizophrenia spectrum disorders...
July 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28600913/glucose-self-monitoring-in-non-insulin-treated-patients-with-type-2-diabetes-in-primary-care-settings-a-randomized-trial
#12
Laura A Young, John B Buse, Mark A Weaver, Maihan B Vu, C Madeline Mitchell, Tamara Blakeney, Kimberlea Grimm, Jennifer Rees, Franklin Niblock, Katrina E Donahue
Importance: The value of self-monitoring of blood glucose (SMBG) levels in patients with non-insulin-treated type 2 diabetes has been debated. Objective: To compare 3 approaches of SMBG for effects on hemoglobin A1c levels and health-related quality of life (HRQOL) among people with non-insulin-treated type 2 diabetes in primary care practice. Design, Setting, and Participants: The Monitor Trial study was a pragmatic, open-label randomized trial conducted in 15 primary care practices in central North Carolina...
July 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28598049/diabetes-drug-prescription-pattern-and-awareness-among-health-care-providers-in-sub-himalayan-region-of-india-a-population-based-study
#13
Jatinder Mokta, Kiran Mokta, Asha Ranjan, Ivan Joshi, Mahak Garg
BACKGROUND: To determine the pattern of diabetic drug prescription and awareness about diabetes among primary health providers in the rural areas of Himachal Pradesh situated in the western Himalayas at an elevation range from 350 meters (1,148ft) to 6900 meters (22,966ft) above sea level. METHODS AND MATERIAL: Study was conducted in 20 rural areas of Himachal Pradesh, located 50 to 400 Km from state capital, at 2200 to 10,000 feet altitude. Non-pregnant diabetic adults were surveyed through 31 diabetic camps...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28596237/the-snare-protein-syntaxin1a-plays-an-essential-role-in-biphasic-exocytosis-of-the-incretin-hormone-glucagon-like-peptide-1
#14
Sarah E Wheeler, Holly M Stacey, Yasaman Nahaei, Stephen J Hale, Alexandre B Hardy, Frank Reimann, Fiona M Gribble, Pierre Larraufie, Herbert Y Gaisano, Patricia L Brubaker
Exocytosis of the hormone, glucagon-like peptide-1 (GLP-1), by the intestinal L-cell is essential for the incretin effect after nutrient ingestion, and is critical for the actions of dipeptidylpeptidase IV inhibitors that enhance GLP-1 levels in patients with type 2 diabetes. 2-Photon microscopy revealed that exocytosis of GLP-1 is biphasic, with a 1(st) peak at 1-6min and a 2(nd) peak at 7-12min after stimulation with forskolin. Approximately 75% of the exocytotic events were represented by compound granule fusion, and the remainder were accounted for by full fusion of single granules, under basal and stimulated conditions...
June 8, 2017: Diabetes
https://www.readbyqxmd.com/read/28591776/efficacy-and-safety-of-mini-dose-glucagon-for-treatment-of-non-severe-hypoglycemia-in-adults-with-type-1-diabetes
#15
Morey W Haymond, Stephanie N DuBose, Michael R Rickels, Howard Wolpert, Viral N Shah, Jennifer L Sherr, Ruth S Weinstock, Shivani Agarwal, Alandra S Verdejo, Martin J Cummins, Brett Newswanger, Roy W Beck
Context: Standard treatment for hypoglycemia is oral carbohydrate, but often results in hyperglycemia and requires extra caloric intake. Objective: To evaluate the use of low-dose glucagon to treat mild hypoglycemia in ambulatory adults with type 1 diabetes (T1D). Design: Randomized crossover trial (two 3-week periods). Setting: Five U.S. diabetes clinics. Patients: Twenty adults with T1D using an insulin pump and continuous glucose monitor (CGM) and experiencing frequent mild hypoglycemia...
June 7, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28580101/highly-specific-and-rapid-glycan-based-amperometric-detection-of-influenza-viruses
#16
Xikai Cui, Amrita Das, Abasaheb N Dhawane, Joyce Sweeney, Xiaohu Zhang, Vasanta Chivukula, Suri S Iyer
Rapid and precise detection of influenza viruses in a point of care setting is critical for applying appropriate countermeasures. Current methods such as nucleic acid or antibody based techniques are expensive or suffer from low sensitivity, respectively. We have developed an assay that uses glucose test strips and a handheld potentiostat to detect the influenza virus with high specificity. Influenza surface glycoprotein neuraminidase (NA), but not bacterial NA, cleaved galactose bearing substrates, 4,7di-OMe N-acetylneuraminic acid attached to the 3 or 6 position of galactose, to release galactose...
May 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28569076/clinical-impact-of-blood-glucose-monitoring-accuracy-an-in-silico-study
#17
Enrique Campos-Náñez, Kurt Fortwaengler, Marc D Breton
BACKGROUND: Patients with diabetes rely on blood glucose (BG) monitoring devices to manage their condition. As some self-monitoring devices are becoming more and more accurate, it becomes critical to understand the relationship between system accuracy and clinical outcomes, and the potential benefits of analytical accuracy. METHODS: We conducted a 30-day in-silico study in type 1 diabetes mellitus (T1DM) patients using continuous subcutaneous insulin infusion (CSII) therapy and a variety of BG meters, using the FDA-approved University of Virginia (UVA)/Padova Type 1 Simulator...
May 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28560900/effect-of-bgm-accuracy-on-the-clinical-performance-of-cgm-an-in-silico-study
#18
Enrique Campos-Náñez, Marc D Breton
BACKGROUND: Standard management of type 1 diabetes (T1D) relies on blood glucose monitoring based on a range of technologies from self-monitoring of blood glucose (BGM) to continuous glucose monitoring (CGM). Even as CGM technology matures, patients utilize BGM for calibration and dosing. The question of how the accuracy of both technologies interact is still not well understood. METHODS: We use a recently developed data-driven simulation approach to characterize the relationship between CGM and BGM accuracy especially how BGM accuracy impacts CGM performance in four different use cases with increasing levels of reliance on twice daily calibrated CGM...
May 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28557817/accuracy-of-capillary-and-arterial-whole-blood-glucose-measurements-using-a-glucose-meter-in-patients-under-general-anesthesia-in-the-operating-room
#19
Brad S Karon, Leslie J Donato, Chelsie M Larsen, Lindsay K Siebenaler, Amy E Wells, Christina M Wood-Wentz, Mary E Shirk-Marienau, Timothy B Curry
BACKGROUND: The aim of this study was to evaluate the use of a glucose meter with surgical patients under general anesthesia in the operating room. METHODS: Glucose measurements were performed intraoperatively on 368 paired capillary and arterial whole blood samples using a Nova StatStrip (Nova Biomedical, USA) glucose meter and compared with 368 reference arterial whole blood glucose measurements by blood gas analyzer in 196 patients. Primary outcomes were median bias (meter minus reference), percentage of glucose meter samples meeting accuracy criteria for subcutaneous insulin dosing as defined by Parkes error grid analysis for type 1 diabetes mellitus, and accuracy criteria for intravenous insulin infusion as defined by Clinical and Laboratory Standards Institute guidelines...
May 30, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28555339/role-of-mobile-technology-to-improve-diabetes-care-in-adults-with-type-1-diabetes-the-remote-t1d-study-ibgstar-%C3%A2-in-type-1-diabetes-management
#20
Satish K Garg, Viral N Shah, Halis K Akturk, Christie Beatson, Janet K Snell-Bergeon
INTRODUCTION: The role of mobile technology in patient-reported outcomes (PRO) and glycemic control in adults with type 1 diabetes (T1D) needs further evaluation. METHODS: The single-center, prospective, 6-month, open-label, investigator-initiated study randomized 100 subjects with T1D in a 1:1 fashion to a control group using self-monitoring of blood glucose (SMBG) with Accu-Chek Nano(®) and an intervention group using SMBG with iPhone plus glucose meter (iBGStar(®))...
May 29, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
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