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https://www.readbyqxmd.com/read/28626983/comparison-of-systemic-pharmacodynamic-effects-of-two-combination-pressurised-metered-dose-inhalers-that-deliver-salmeterol-and-fluticasone-propionate
#1
Lester I Harrison, Victoria Sessions, Christopher J Wiggenhorn, David Chalmers, Pui Leung, John Efthimiou
AIM: The aim was to test the systemic pharmacodynamic effects of the salmeterol component of two pressurized metered dose inhalers that delivered a combination of salmeterol and fluticasone propionate (SM/FP). METHODS: This was a six-way crossover study in 43 adult subjects, using a single blind design (subject blinded to product and clinical assessor blinded for all measurements). Each subject received single doses of 2, 6, and 12 inhalations from test and reference products that delivered SM/FP as 25/125 mcg per inhalation...
June 19, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28617624/how-satisfied-are-patients-when-their-choice-of-funded-glucose-meter-is-restricted-to-a-single-brand
#2
Christy Macdonald, Helen Lunt, Michelle Downie, Deborah Kendall
BACKGROUND: Many governments and insurers are driving down the cost of medical devices, including glucose meters, by the central management of purchasing decisions. We report patients' responses to an "enforced" change in brand of glucose meter, one year after the introduction of a national sole supplier arrangement for funded glucose meters and strips. METHOD: Specialist diabetes clinic attendees from two geographical locations completed a questionnaire one year after the final meter changeover date...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28617617/accuracy-and-user-performance-evaluation-of-a-new-wireless-enabled-blood-glucose-monitoring-system-that-links-to-a-smart-mobile-device
#3
Timothy S Bailey, Jane F Wallace, Scott Pardo, Mary Ellen Warchal-Windham, Bern Harrison, Robert Morin, Mark Christiansen
BACKGROUND: The new Contour(®)Plus ONE blood glucose monitoring system (BGMS) features an easy-to-use, wireless-enabled blood glucose meter that links to a smart mobile device via Bluetooth(®) connectivity and can sync with the Contour(™) Diabetes app on a smartphone or tablet. METHODS: The accuracy of the new BGMS was assessed in 2 studies according to ISO 15197:2013 criteria. In Study 1 (laboratory study), fingertip capillary blood samples from 100 subjects were tested in duplicate using 3 test strip lots...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28611921/adherence-of-self-monitoring-of-blood-glucose-in-persons-with-type-1-diabetes-in-sweden
#4
Peter Moström, Elsa Ahlén, Henrik Imberg, Per-Olof Hansson, Marcus Lind
OBJECTIVE: The primary aim was to evaluate the extent to which persons with type 1 diabetes perform self-monitoring of blood glucose (SMBG) according to guidelines. Secondary objectives were to investigate predictors for good SMBG adherence, reasons for non-adherence, and association between SMBG frequency and hemoglobin A1c (HbA1c). METHODS: This was a survey-based cross-sectional study. Questionnaires were sent out to 600 random patients at five sites. Patients were included if they were diagnosed with type 1 diabetes and ≥18 years old and excluded if they were currently using continuous glucose monitoring (CGM)...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28601891/effect-of-liraglutide-treatment-on-prediabetes-and-overweight-or-obesity-in-clozapine-or-olanzapine-treated-patients-with-schizophrenia-spectrum-disorder-a-randomized-clinical-trial
#5
Julie R Larsen, Louise Vedtofte, Mathilde S L Jakobsen, Hans R Jespersen, Michelle I Jakobsen, Camilla K Svensson, Kamuran Koyuncu, Ole Schjerning, Peter S Oturai, Andreas Kjaer, Jimmi Nielsen, Jens J Holst, Claus T Ekstrøm, Christoph U Correll, Tina Vilsbøll, Anders Fink-Jensen
Importance: Compared with the general population, patients with schizophrenia have a 2- to 3-fold higher mortality rate primarily caused by cardiovascular disease. Previous interventions designed to counteract antipsychotic-induced weight gain and cardiometabolic disturbances reported limited effects. Objectives: To determine the effects of the glucagon-like peptide-1 receptor agonist liraglutide added to clozapine or olanzapine treatment of schizophrenia spectrum disorders...
June 10, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28600913/glucose-self-monitoring-in-non-insulin-treated-patients-with-type-2-diabetes-in-primary-care-settings-a-randomized-trial
#6
Laura A Young, John B Buse, Mark A Weaver, Maihan B Vu, C Madeline Mitchell, Tamara Blakeney, Kimberlea Grimm, Jennifer Rees, Franklin Niblock, Katrina E Donahue
Importance: The value of self-monitoring of blood glucose (SMBG) levels in patients with non-insulin-treated type 2 diabetes has been debated. Objective: To compare 3 approaches of SMBG for effects on hemoglobin A1c levels and health-related quality of life (HRQOL) among people with non-insulin-treated type 2 diabetes in primary care practice. Design, Setting, and Participants: The Monitor Trial study was a pragmatic, open-label randomized trial conducted in 15 primary care practices in central North Carolina...
June 10, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28598049/diabetes-drug-prescription-pattern-and-awareness-among-health-care-providers-in-sub-himalayan-region-of-india-a-population-based-study
#7
Jatinder Mokta, Kiran Mokta, Asha Ranjan, Ivan Joshi, Mahak Garg
BACKGROUND: To determine the pattern of diabetic drug prescription and awareness about diabetes among primary health providers in the rural areas of Himachal Pradesh situated in the western Himalayas at an elevation range from 350 meters (1,148ft) to 6900 meters (22,966ft) above sea level. METHODS AND MATERIAL: Study was conducted in 20 rural areas of Himachal Pradesh, located 50 to 400 Km from state capital, at 2200 to 10,000 feet altitude. Non-pregnant diabetic adults were surveyed through 31 diabetic camps...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28596237/the-snare-protein-syntaxin1a-plays-an-essential-role-in-biphasic-exocytosis-of-the-incretin-hormone-glucagon-like-peptide-1
#8
Sarah E Wheeler, Holly M Stacey, Yasaman Nahaei, Stephen J Hale, Alexandre B Hardy, Frank Reimann, Fiona M Gribble, Pierre Larraufie, Herbert Y Gaisano, Patricia L Brubaker
Exocytosis of the hormone, glucagon-like peptide-1 (GLP-1), by the intestinal L-cell is essential for the incretin effect after nutrient ingestion, and is critical for the actions of dipeptidylpeptidase IV inhibitors that enhance GLP-1 levels in patients with type 2 diabetes. 2-Photon microscopy revealed that exocytosis of GLP-1 is biphasic, with a 1(st) peak at 1-6min and a 2(nd) peak at 7-12min after stimulation with forskolin. Approximately 75% of the exocytotic events were represented by compound granule fusion, and the remainder were accounted for by full fusion of single granules, under basal and stimulated conditions...
June 8, 2017: Diabetes
https://www.readbyqxmd.com/read/28591776/efficacy-and-safety-of-mini-dose-glucagon-for-treatment-of-non-severe-hypoglycemia-in-adults-with-type-1-diabetes
#9
Morey W Haymond, Stephanie N DuBose, Michael R Rickels, Howard Wolpert, Viral N Shah, Jennifer L Sherr, Ruth S Weinstock, Shivani Agarwal, Alandra S Verdejo, Martin J Cummins, Brett Newswanger, Roy W Beck
Context: Standard treatment for hypoglycemia is oral carbohydrate, but often results in hyperglycemia and requires extra caloric intake. Objective: To evaluate the use of low-dose glucagon to treat mild hypoglycemia in ambulatory adults with type 1 diabetes (T1D). Design: Randomized crossover trial (two 3-week periods). Setting: Five U.S. diabetes clinics. Patients: Twenty adults with T1D using an insulin pump and continuous glucose monitor (CGM) and experiencing frequent mild hypoglycemia...
June 7, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28580101/highly-specific-and-rapid-glycan-based-amperometric-detection-of-influenza-viruses
#10
Xikai Cui, Amrita Das, Abasaheb N Dhawane, Joyce Sweeney, Xiaohu Zhang, Vasanta Chivukula, Suri S Iyer
Rapid and precise detection of influenza viruses in a point of care setting is critical for applying appropriate countermeasures. Current methods such as nucleic acid or antibody based techniques are expensive or suffer from low sensitivity, respectively. We have developed an assay that uses glucose test strips and a handheld potentiostat to detect the influenza virus with high specificity. Influenza surface glycoprotein neuraminidase (NA), but not bacterial NA, cleaved galactose bearing substrates, 4,7di-OMe N-acetylneuraminic acid attached to the 3 or 6 position of galactose, to release galactose...
May 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28569076/clinical-impact-of-blood-glucose-monitoring-accuracy-an-in-silico-study
#11
Enrique Campos-Náñez, Kurt Fortwaengler, Marc D Breton
BACKGROUND: Patients with diabetes rely on blood glucose (BG) monitoring devices to manage their condition. As some self-monitoring devices are becoming more and more accurate, it becomes critical to understand the relationship between system accuracy and clinical outcomes, and the potential benefits of analytical accuracy. METHODS: We conducted a 30-day in-silico study in type 1 diabetes mellitus (T1DM) patients using continuous subcutaneous insulin infusion (CSII) therapy and a variety of BG meters, using the FDA-approved University of Virginia (UVA)/Padova Type 1 Simulator...
May 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28560900/effect-of-bgm-accuracy-on-the-clinical-performance-of-cgm-an-in-silico-study
#12
Enrique Campos-Náñez, Marc D Breton
BACKGROUND: Standard management of type 1 diabetes (T1D) relies on blood glucose monitoring based on a range of technologies from self-monitoring of blood glucose (BGM) to continuous glucose monitoring (CGM). Even as CGM technology matures, patients utilize BGM for calibration and dosing. The question of how the accuracy of both technologies interact is still not well understood. METHODS: We use a recently developed data-driven simulation approach to characterize the relationship between CGM and BGM accuracy especially how BGM accuracy impacts CGM performance in four different use cases with increasing levels of reliance on twice daily calibrated CGM...
May 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28557817/accuracy-of-capillary-and-arterial-whole-blood-glucose-measurements-using-a-glucose-meter-in-patients-under-general-anesthesia-in-the-operating-room
#13
Brad S Karon, Leslie J Donato, Chelsie M Larsen, Lindsay K Siebenaler, Amy E Wells, Christina M Wood-Wentz, Mary E Shirk-Marienau, Timothy B Curry
BACKGROUND: The aim of this study was to evaluate the use of a glucose meter with surgical patients under general anesthesia in the operating room. METHODS: Glucose measurements were performed intraoperatively on 368 paired capillary and arterial whole blood samples using a Nova StatStrip (Nova Biomedical, USA) glucose meter and compared with 368 reference arterial whole blood glucose measurements by blood gas analyzer in 196 patients. Primary outcomes were median bias (meter minus reference), percentage of glucose meter samples meeting accuracy criteria for subcutaneous insulin dosing as defined by Parkes error grid analysis for type 1 diabetes mellitus, and accuracy criteria for intravenous insulin infusion as defined by Clinical and Laboratory Standards Institute guidelines...
May 30, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28555339/role-of-mobile-technology-to-improve-diabetes-care-in-adults-with-type-1-diabetes-the-remote-t1d-study-ibgstar-%C3%A2-in-type-1-diabetes-management
#14
Satish K Garg, Viral N Shah, Halis K Akturk, Christie Beatson, Janet K Snell-Bergeon
INTRODUCTION: The role of mobile technology in patient-reported outcomes (PRO) and glycemic control in adults with type 1 diabetes (T1D) needs further evaluation. METHODS: The single-center, prospective, 6-month, open-label, investigator-initiated study randomized 100 subjects with T1D in a 1:1 fashion to a control group using self-monitoring of blood glucose (SMBG) with Accu-Chek Nano(®) and an intervention group using SMBG with iPhone plus glucose meter (iBGStar(®))...
May 29, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28551184/the-effect-of-different-treatments-for-early-lactation-hyperketonemia-on-blood-%C3%AE-hydroxybutyrate-plasma-nonesterified-fatty-acids-glucose-insulin-and-glucagon-in-dairy-cattle
#15
S Mann, F A Leal Yepes, E Behling-Kelly, J A A McArt
Despite increased efforts in preventing the occurrence of metabolic disorders in transition cows, hyperketonemia remains a frequent early-lactation metabolic disease affecting an average of 40% of cows in herds in the United States. Despite the demonstrated economic effect of this disorder, controlled clinical trials comparing different treatment strategies in affected cows are lacking. The objective of our study was to investigate the effect of treatment with intravenous glucose, oral propylene glycol, or a combination of both on the reduction in blood β-hydroxybutyrate (BHB) concentrations of early-lactation hyperketonemic dairy cows...
May 24, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28545493/three-approaches-to-glucose-monitoring-in-non-insulin-treated-diabetes-a-pragmatic-randomized-clinical-trial-protocol
#16
Laura A Young, John B Buse, Mark A Weaver, Maihan B Vu, April Reese, C Madeline Mitchell, Tamara Blakeney, Kimberlea Grimm, Jennifer Rees, Katrina E Donahue
BACKGROUND: For the nearly 75% of patients living with type 2 diabetes (T2DM) that do not use insulin, decisions regarding self-monitoring of blood glucose (SMBG) can be especially problematic. While in theory SMBG holds great promise for sparking favorable behavior change, it is a resource intensive activity without firmly established patient benefits. This study describes our study protocol to assess the impact of three different SMBG testing approaches on patient-centered outcomes in patients with non-insulin treated T2DM within a community-based, clinic setting...
May 25, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28541796/retraction-of-rt-mcgrath-et-al-evaluation-of-blood-glucose-meter-efficacy-in-an-antenatal-diabetes-clinic-diabetes-technol-ther-2016-18-2-68-74-doi-10-1089-dia-2015-0104
#17
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28540104/pseudohyperglycemia-effects-of-unwashed-hand-after-fruit-peeling-or-handling-on-fingertips-blood-glucose-monitoring-results
#18
M A Olamoyegun, T Oloyede, O G Adewoye, S O Abdulkarim, A A Adeleke
BACKGROUND: Self-monitoring of blood glucose (SMBG) is an important component of management for diabetes mellitus (DM), especially in T1DM and T2DM patients who are on insulin therapy. Adequate blood glucose monitoring and prompt intervention are necessary to prevent blood glucose (BG) fluctuation and delay long-term diabetes complications. People with DM are advised to clean their hands before SMBG to remove any dirt or food residue that might affect the reading. AIM: The study tested the hypothesis that falsely elevated BG levels from fingertip occur after peeling or handling fruits in an unwashed hand...
November 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/28513731/ag-au-nanoprism-metal-organic-framework-based-paper-for-extending-the-glucose-sensing-range-in-human-serum-and-urine
#19
Pin-Hsuan Huang, Chia Ping Hong, Jian Fan Zhu, Tzu-Ting Chen, Chu-Ting Chan, Yu-Chien Ko, Tien-Li Lin, Zheng-Bang Pan, Ning-Kuei Sun, Ying-Chu Wang, Jong-Jheng Luo, Tzu-Chieh Lin, Chia-Cheng Kang, Jing-Jong Shyue, Mei-Lin Ho
In this work, we present a Ag@Au nanoprism-metal-organic framework-paper based glucose sensor for rapid, sensitive, single-use and quantitative glucose determination in human serum. To achieve painless measurement of glucose with a non-invasive detection methodology, this biosensor was further tested in human urine. In this approach, a new hybrid-Ag@Au nanoprism loaded in close proximity to micrometer sized coordination polymers as phosphorescent luminophores significantly enhanced the emission intensity due to metal-enhanced phosphorescence and worked as reaction sites to support more dissolved oxygen...
May 30, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28501411/short-communication-associations-between-blood-glucose-concentration-onset-of-hyperketonemia-and-milk-production-in-early-lactation-dairy-cows
#20
J Ruoff, S Borchardt, W Heuwieser
The objectives of this study were to describe the associations between hypoglycemia and the onset of hyperketonemia (HYK) within the first 6 wk of lactation, to evaluate the effects of body condition score at calving on glucose concentration, and to study the effects of hypoglycemia on milk production. A total of 621 dairy cows from 6 commercial dairy farms in Germany were enrolled between 1 and 4 d in milk (DIM). Cows were tested twice weekly using an electronic handheld meter for glucose and β-hydroxybutyrate (BHB), respectively, for a period of 42 d...
July 2017: Journal of Dairy Science
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