Read by QxMD icon Read

cancer stem cells

Michał Antoszczak, Alicja Urbaniak, Magdalena Delgado, Ewa Maj, Björn Borgström, Joanna Wietrzyk, Adam Huczyński, Youzhong Yuan, Timothy C Chambers, Daniel Strand
The polyether ionophore salinomycin has recently captured much interest due to its potent activity against multi-drug resistant cancer cells and cancer stem cells. Previous studies have shown that either acylation of the C20 position or esterification/amidation of the C1 carboxylate moiety is beneficial in terms of biological properties. In this paper, we present the first analogs combining such modifications. Evaluation of the anti-proliferative activity against a series of cancer cell lines showed that acylation of the C20 hydroxyl group improves the activity of salinomycin C1 amides but not of the corresponding C1 esters...
July 10, 2018: European Journal of Medicinal Chemistry
Cesar A Sommer, Amalia Capilla, Francisco J Molina-Estevez, Andreia Gianotti-Sommer, Nicholas Skvir, Ignacio Caballero, Sanjib Chowdhury, Gustavo Mostoslavsky
Mutations in the gene Adenomatous Polyposis Coli or APC appear in most sporadic cases of colorectal cancer and it is the most frequent mutation causing hereditary Familial Adenomatous Polyposis. The detailed molecular mechanism by which APC mutations predispose to the development of colorectal cancer is not completely understood. This is in part due to the lack of accessibility to appropriate models that recapitulate the early events associated with APC mediated intestinal transformation. We have established a novel platform utilizing human induced Pluripotent Stem cells or iPSC from normal or FAP-specific APC mutant individuals and evaluated the effect of the mutation in the cells before and after differentiation into intestinal organoids...
2018: PloS One
Neval Ete Wareham, Caspar Da Cunha-Bang, Álvaro H Borges, Christina Ekenberg, Jan Gerstoft, Finn Gustafsson, Ditte Hansen, Carsten Heilmann, Marie Helleberg, Jens Hillingsø, Paul Suno Krohn, Isabelle Paula Lodding, Thomas Kromann Lund, Louise Lundgren, Amanda Mocroft, Michael Perch, Søren Lykke Petersen, Irma Petruskevicius, Allan Rasmussen, Kasper Rossing, Andreas A Rostved, Henrik Sengeløv, Vibeke Rømming Sørensen, Søren Schwartz Sørensen, Jens D Lundgren
Correct classification of death causes is an important component of transplant trials.We aimed to develop and validate a system to classify causes of death in hematopoietic stem cell (HSCT) and solid organ (SOT) transplant recipients.Case record forms (CRF) of fatal cases were completed, including investigator-designated cause of death. Deaths occurring in 2010 to 2013 were used for derivation; and were validated by deaths occurring in 2013 to 2015. Underlying cause of death (referred to as recorded underlying cause) was determined through a central adjudication process involving 2 external reviewers, and subsequently compared with the Danish National Death Cause Registry...
July 2018: Medicine (Baltimore)
Nathan Beals, Praveena S Thiagarajan, Eric Soehnlen, Arijit Das, Ofer Reizes, Justin D Lathia, Soumitra Basu
The CD44 receptor is common among many cancer types where overexpression is synonymous with poor prognosis in prostate, glioma, and breast cancer. More notably CD44 overexpression has been shown in a number of different cancer stem cells (CSC) which are present in many solid tumors and drive growth, recurrence, and resistance to conventional therapies. Triple negative breast cancer CSCs correlate to worse prognosis and early relapse due to higher drug resistance and increased tumor heterogeneity and thus are prime targets for anticancer therapy...
November 30, 2017: ACS Omega
Xiulan Zhao, Baocun Sun, Tieju Liu, Bing Shao, Ran Sun, Dongwang Zhu, Yanhui Zhang, Qiang Gu, Xueyi Dong, Fang Liu, Nan Zhao, Danfang Zhang, Yanlei Li, Jie Meng, Wenchen Gong, Yanjun Zheng, Xu Zheng
Vasculogenic mimicry (VM) refers to the unique capability of aggressive tumor cells to mimic the pattern of embryonic vasculogenic networks. Cancer stem cells (CSCs) represent a subpopulation of tumor cells endowed with the capacity for self-renewal and multi-lineage differentiation. Previous studies have indicated that CSCs may participate in the formation of VM. With the advance of high-resolution microarrays and massively parallel sequencing technology, long non-coding RNAs (lncRNAs) are suggested to play a critical role in the tumorigenesis and, in particular, the development of human hepatocellular carcinoma (HCC)...
July 19, 2018: Cancer Science
Nam-Gu Her, Jeong-Woo Oh, Yun Jeong Oh, Suji Han, Hee Jin Cho, Yeri Lee, Gyu Ha Ryu, Do-Hyun Nam
Testing new ways to identify untapped opportunities for glioblastoma therapies remains highly significant. Amplification and overexpression of MDM2 gene is frequent in glioblastoma and disrupting the MDM2-p53 interaction is a promising strategy to treat the cancer. RG7112 is the first-in class inhibitor and recently discovered AMG232 is the most potent MDM2 inhibitor known to date. Here, we compared the effects of these two clinical MDM2 inhibitors in six glioblastoma cell lines and ten patient-derived glioblastoma stem cells...
July 18, 2018: Cell Death & Disease
Yubo Tang, Jincheng Pan, Shuai Huang, Xinsheng Peng, Xuenong Zou, Yongxiang Luo, Dong Ren, Xin Zhang, Ronggang Li, Peiheng He, Qingde Wa
BACKGROUND: Bone metastasis is a leading cause of morbidity and mortality in advanced prostate cancer (PCa). Downexpression of miR-133a-3p has been found to contribute to the progression, recurrence and distant metastasis in PCa. However, clinical significance of miR-133a-3p in bone metastasis of PCa, and the biological role of miR-133a-3p and its molecular mechanisms underlying bone metastasis of PCa remain unclear. METHODS: miR-133a-3p expression was evaluated in 245 clinical PCa tissues by real-time PCR...
July 18, 2018: Journal of Experimental & Clinical Cancer Research: CR
Bo Zhu, Yichao Wang, Xiaolin Wang, Shiwu Wu, Lei Zhou, Xiaomeng Gong, Wenqing Song, Danna Wang
BACKGROUND: Metastasis-associated in colon cancer 1 (MACC1) has been reported to promote tumor cell invasion and metastasis. Cancer stem cells and epithelial-mesenchymal transition (EMT) have also been reported to promote tumor cell proliferation, invasion, and metastasis. KiSS-1, a known suppressor of metastasis, has been reported to be down-regulated in various tumors. However, the associations of MACC1, CD44, Twist1, and KiSS-1 in colonic adenocarcinoma (CAC) invasion and metastasis remain unclear...
July 18, 2018: Diagnostic Pathology
Jiahui Chu, Yongfei Li, Xuemei Fan, Jingjing Ma, Jun Li, Guangping Lu, Yanhong Zhang, Yi Huang, Wei Li, Xiang Huang, Ziyi Fu, Yongmei Yin, Hongyan Yuan
BACKGROUND/AIMS: High levels of cancer stem cells (CSCs) in patients with triple-negative breast cancer (TNBC) correlate with risk of poor clinical outcome and possibly contribute to chemoresistance and metastasis in patients with highly malignant TNBC. Aberrant microRNA expression is associated with the dysfunction of self-renewal and proliferation in cancer stem cells, while there is little information about the TNBC-specific microRNAs in regulating CSC ability. METHODS: Solexa deep sequencing was performed to detect the expression levels of TNBC or non-TNBC stem cells (CSCs) microRNAs...
July 18, 2018: Cellular Physiology and Biochemistry
Sakthivignesh Ponandai-Srinivasan, Karin L Andersson, Monica Nister, Merli Saare, Halima A Hassan, Suby J Varghese, Maire Peters, Andres Salumets, Kristina Gemzell-Danielsson, Parameswaran Grace Luther Lalitkumar
STUDY QUESTION: Is there molecular evidence for a link between endometriosis and endometriosis-associated ovarian cancers (EAOC)? STUDY ANSWER: We identified aberrant gene expression signatures associated with malignant transformation in a small subgroup of women with ovarian endometriosis. WHAT IS KNOWN ALREADY: Epidemiological studies have shown an increased risk of EAOC in women with ovarian endometriosis. However, the cellular and molecular changes leading to EAOC are largely unexplored...
July 18, 2018: Human Reproduction
Nazly Santos, Rocío Rodríguez-Romanos, Rafael de la Cámara, Salut Brunet, Jose B Nieto, Ismael Buño, Carmen Martínez, Antonio Jiménez-Velasco, Carlos Vallejo, Marcos González, Carlos Solano, Christelle Ferrá, Antonia Sampol, Jose A Pérez-Simón, Javier López-Jiménez, José L Díez, David Gallardo
Programmed death 1 (PD-1) activation triggers an immune checkpoint resulting in inhibition of T cells that leads to peripheral tolerance. Some PD-1 polymorphisms have been described and associated with the development of autoimmune diseases or cancer predisposition, but there are few data concerning the relevance of such polymorphisms on the clinical outcome after allogeneic hematopoietic stem cell transplant (alloHSCT). We analyzed the distribution of the SNPs PD-1.1G/A (rs36084323) and PD-1.3G/A (rs11568821) genotypes of the donor in a cohort of 1485 alloHSCT from HLA-identical sibling donors...
July 17, 2018: Annals of Hematology
Rei Mizuno, Kenji Kawada, Yoshiharu Sakai
Although a number of studies have revealed the underlying mechanisms which regulate the development of colorectal cancer (CRC), we have not completely overcome this disease yet. Accumulating evidence has shown that the posttranscriptional regulation by the noncoding RNAs such as microRNAs plays an important role in the development or progression of CRC. Among a number of microRNAs, the let-7 microRNA family that was first discovered in C. elegans and conserved from worms to humans has been linked with the development of many types of cancers including CRC...
2018: Canadian Journal of Gastroenterology & Hepatology
Margreet C M Vissers, Andrew B Das
Whether vitamin C (ascorbate) has a role to play as an anti-cancer agent has been debated for decades. Ascorbate has been used by cancer patients in an unregulated environment, either as a dietary supplement or in pharmacological doses administered by infusion, with numerous reports of clinical benefit, but in the absence of rigorous clinical trial data. The design of appropriate clinical trials has been hindered by a lack of understanding of the mechanism(s) of action that would inform the choice of effective dose, timing of administration and likely responsive cancer models...
2018: Frontiers in Physiology
Mateja Vidic, Tina Smuc, Nika Janez, Michael Blank, Tomaz Accetto, Jan Mavri, Isis C Nascimento, Arthur A Nery, Henning Ulrich, Tamara T Lah
Background: Detection of circulating lung cancer cells with cancer-stem like characteristics would represent an improved tool for disease prognosis. However, current antibodies based methods have some disadvantages and therefore cell SELEX (Systematic Evolution of Ligands by Exponential Enrichment) was used to develop DNA aptamers, recognizing cell surface markers of non-small lung carcinoma (NSLC) cells. Materials and methods: The human adenocarcinoma cell line A549 was used for selection in seven cell SELEX cycles...
June 2018: Radiology and Oncology
Heejeong Lee, Nami Joo
The study investigated antioxidative properties and rectal cancer cell inhibition effect of amaranth (Amaranthus cruentus L.) cauline leaves (ACL) to produce the sausage with ACL powder (ACLP). Antioxidative effects of ACLP prepared with different stem lengths (10-45 cm) were evaluated through DPPH, ABTS, reducing power, total phenol, and total flavonoid. Inhibition effect on rectal cancer cells growth was also examined with CT-26 cell. To determine appropriate ACL amounts in sausage formula, response surface methodology was used...
July 2018: Korean Journal for Food Science of Animal Resources
Judy S Crabtree, Lucio Miele
Breast cancer stem cells (BCSC) have been implicated in tumor initiation, progression, metastasis, recurrence, and resistance to therapy. The origins of BCSCs remain controversial due to tumor heterogeneity and the presence of such small side populations for study, but nonetheless, cell surface markers and their correlation with BCSC functionality continue to be identified. BCSCs are driven by persistent activation of developmental pathways, such as Notch, Wnt, Hippo, and Hedgehog and new treatment strategies that are aimed at these pathways are in preclinical and clinical development...
July 17, 2018: Biomedicines
Oluwaseun Adebayo Bamodu, Kuang-Tai Kuo, Li-Ping Yuan, Wei-Hong Cheng, Wei-Hwa Lee, Yuan-Soon Ho, Tsu-Yi Chao, Chi-Tai Yeh
Failure to eradicate hematologic cancer stem cells (hCSCs) associated with resistance to tyrosine kinase inhibitors such as imatinib mesylate (IM) in chronic myeloid leukemia (CML) patients is a clinical challenge that highlights the need for discovering and developing therapeutic strategies that target and eliminate these hCSCs. Herein, we document the essential role of the interplay between histone deacetylases (HDACs), the polycomb group proteins, pluripotency transcription factors and the cell cycle machinery in the viability, oncogenicity and therapy evasion of IM-resistant CD34+/CD38- CML stem cells (CML-SCs)...
July 12, 2018: Experimental Cell Research
Ashlee M Strubberg, Daniel A Veronese Paniagua, Tingting Zhao, Leeran Dublin, Thomas Pritchard, Peter O Bayguinov, James A J Fitzpatrick, Blair B Madison
Intestinal epithelial stem cell (IESC) fate is promoted by two major transcriptional regulators, the TCF4/β-catenin complex and ASCL2, which drive expression of IESC-specific factors, including Lgr5, Ephb2, and Rnf43. Canonical Wnt signaling via TCF4/β-catenin directly transactivates Ascl2, which in turn auto-regulates its own expression. Conversely, Let-7 microRNAs antagonize the IESC lineage by repressing specific mRNA targets. Here, we identify the zinc finger transcription factor PLAGL2 as a Let-7 target that regulates IESC fate...
July 9, 2018: Stem Cell Reports
Caterina A M La Porta, Stefano Zapperi
Facing metastasis is the most pressing challenge of cancer research. In this review, we discuss recent advances in understanding phenotypic plasticity of cancer cells, highlighting the kinetics of cancer stem cell and the role of the epithelial mesenchymal transition for metastasis. It appears that the tumor micro-environment plays a crucial role in triggering phenotypic transitions, as we illustrate discussing the challenges posed by macrophages and cancer associated fibroblasts. To disentangle the complexity of environmentally induced phenotypic transitions, there is a growing need for novel advanced algorithms as those proposed in our recent work combining single cell data analysis and numerical simulations of gene regulatory networks...
July 11, 2018: Seminars in Cancer Biology
Guoqiang Chang, Jia-Shiun Leu, Li Ma, Keping Xie, Suyun Huang
Among myriads of distinct chemical modification in RNAs, the dynamic, reversible and fine-tuned methylation of N6 -methyladenosine (m6 A) is the most prevalent modification in eukaryotic mRNAs. This RNA mark is generated by proteins that act as m6 A writers and can be reversed by proteins that act as m6 A erasers. The RNA m6 A modification is also mediated by another group of proteins capable of recognizing m6 A that act as m6 A readers. The m6 A modification exerts direct control over the RNA metabolism including mRNA processing, mRNA exporting, translation initiation, mRNA stability and the biogenesis of long-non-coding RNA (LncRNA), thereby can influence various aspects of cell function...
July 12, 2018: Cytokine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"