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sevoflurane preconditioning

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https://www.readbyqxmd.com/read/28893433/effects-of-remote-ischemic-preconditioning-in-patients-with-concentric-myocardial-hypertrophy-a-randomized-controlled-trial-with-molecular-insights
#1
Young Song, Jong Wook Song, Sak Lee, Ji-Hae Jun, Young-Lan Kwak, Jae-Kwang Shim
BACKGROUND: Efficacy of remote ischemic preconditioning (RIPC) for cardioprotection in cardiac surgery is controversial. We aimed to evaluate the clinical and molecular effects of RIPC on the concentrically hypertrophied myocardium. METHODS: Seventy-two aortic stenosis patients receiving aortic valve replacement (AVR) under sevoflurane anesthesia were randomly allocated to RIPC (3cycles of 5-min inflation [300mmHg] and deflation on the left arm) or control (deflated cuff placement) group...
September 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28875959/downregulation-of-na-ca-2-exchanger-isoform-1-protects-isolated-hearts-by-sevoflurane-postconditioning-but-not-by-delayed-remote-ischemic-preconditioning-in-rats
#2
Yang Yu, Cheng-Hui Zhou, Yun-Tai Yao, Li-Huan Li
Background: Calcium regulatory proteins-L-type Ca(2+) channels (LTCCs), ryanodine receptor 2 (RyR2), and Na(+)/Ca(2+) exchanger isoform 1 (NCX1) have been recognized as important protective mechanisms during myocardial ischemia-reperfusion injury (I/RI). Both sevoflurane postconditioning (SevoPoC) and delayed remote ischemic preconditioning (DRIPC) have been shown to protect the heart against I/RI. In this study, we aimed to compare the effects of SevoPoC and DRIPC on the expression of the three calcium regulatory proteins in an isolated rat heart model...
September 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28870848/sevoflurane-induced-cardioprotection-in-coronary-artery-bypass-graft-surgery-randomised-trial-with-clinical-and-ex-vivo-endpoints
#3
Sandrine Lemoine, Lan Zhu, Jean-Louis Grard, Jean-Luc Hanouz
BACKGROUND: Myocardial ischemia reperfusion injury following cardiac surgery with cardiopulmonary bypass increases postoperative mortality. Setting techniques to protect the heart during this critical period therefore represents a considerable challenge. METHOD: A randomised controlled study in Caen University Hospital Centre, investigated whether the clinical cardio protective effects of administration sevoflurane before cardiopulmonary bypass during coronary artery bypass graft surgery (CABG) could translate into protected atrial trabeculae contractility against hypoxia-reoxygenation in vitro...
September 1, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/28708712/extended-second-window-of-protection-of-sevoflurane-induced-preconditioning
#4
Friederike Behmenburg, Yvonne Boekholt, Patrick van Caster, Marianne Dorsch, André Heinen, Markus W Hollmann, Ragnar Huhn
Late preconditioning (LPC) can be induced by volatile anesthetics and initiates cardioprotection against ischemia/reperfusion injury for three to four days. We investigated the possibility to extend the time window of sevoflurane-induced LPC by repeated sevoflurane administration. An in vivo rat model of regional myocardial ischemia/reperfusion injury was used. Myocardial infarct size was determined by TTC staining at the end of the experiment. In the first series of experiments, male Wistar rats were randomized to five groups (each n=8)...
July 13, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28624055/sevoflurane-preconditioning-protects-from-posttransplant-injury-in-mouse-lung-transplantation
#5
Yoshito Yamada, Isabelle Laube, Jae-Hwi Jang, John M Bonvini, Ilhan Inci, Walter Weder, Beatrice Beck Schimmer, Wolfgang Jungraithmayr
BACKGROUND: Although sevoflurane (Sevo) had been shown to ameliorate posttransplant injury in various organs, data available are inconsistent, particularly in the context of lung transplantation (Tx). We here investigated if preconditioning by Sevo can protect from posttransplant injury regarding both, primary graft dysfunction (PGD) and acute rejection (AR) after experimental lung Tx, thereby focusing on two important clinical outcome parameters. MATERIALS AND METHODS: Three experimental approaches were used: (1) BALB/c mice were preconditioned for 2 h with Sevo or a fentanyl cocktail (Control; n = 10); (2) syngeneic (Syn) mouse lung Tx (C57BL/6) with a Sevo-preconditioned graft followed by 18 h storage to mimic PGD (Syn-Tx, n = 12) versus controls (fentanyl cocktail); and (3) allogeneic (Allo) Tx (BALB/c, donor; C57BL/6, recipient) to mimic AR (Allo-Tx, n = 12) versus controls (fentanyl cocktail)...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28392989/sevoflurane-postconditioning-protects-the-myocardium-against-ischemia-reperfusion-injury-via-activation-of-the-jak2-stat3-pathway
#6
Jianjiang Wu, Jin Yu, Peng Xie, Yiliyaer Maimaitili, Jiang Wang, Long Yang, Haiping Ma, Xing Zhang, Yining Yang, Hong Zheng
BACKGROUND: Sevoflurane postconditioning (S-post) has similar cardioprotective effects as ischemic preconditioning. However, the underlying mechanism of S-post has not been fully elucidated. Janus kinase signaling transduction/transcription activator (JAK2-STAT3) plays an important role in cardioprotection. The purpose of this study was to determine whether the cardioprotective effects of S-post are associated with activation of the JAK2-STAT3 signal pathway. METHODS: An adult male Sprague-Dawley (SD) rat model of myocardial ischemia/reperfusion (I/R) injury was established using the Langendorff isolated heart perfusion apparatus...
2017: PeerJ
https://www.readbyqxmd.com/read/28356068/a-randomized-trial-of-remote-ischemic-preconditioning-and-control-treatment-for-cardioprotection-in-sevoflurane-anesthetized-cabg-patients
#7
Rianne Nederlof, Nina C Weber, Nicole P Juffermans, Bas A M J de Mol, Markus W Hollmann, Benedikt Preckel, Coert J Zuurbier
BACKGROUND: Remote ischemic preconditioning (RIPC) efficacy is debated. Possibly, because propofol, which has a RIPC-inhibiting action, is used in most RIPC trials. It has been suggested that clinical efficacy is, however, present with volatile anesthesia in the absence of propofol, although this is based on one phase 1 trial only. Therefore, in the present study we further explore the relation between RIPC and cardioprotection with perioperative anesthesia restricted to sevoflurane and fentanyl, in CABG patients without concomitant procedures...
March 29, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28352158/cardioprotection-with-halogenated-gases-how-does-it-occur
#8
REVIEW
Jose Luis Guerrero-Orriach, Juan Jose Escalona Belmonte, Alicia Ramirez Fernandez, Marta Ramirez Aliaga, Manuel Rubio Navarro, Jose Cruz Mañas
Numerous studies have studied the effect of halogenated agents on the myocardium, highlighting the beneficial cardiac effect of the pharmacological mechanism (preconditioning and postconditioning) when employed before and after ischemia in patients with ischemic heart disease. Anesthetic preconditioning is related to the dose-dependent signal, while the degree of protection is related to the concentration of the administered drug and the duration of the administration itself. Triggers for postconditioning and preconditioning might have numerous pathways in common; mitochondrial protection and a decrease in inflammatory mediators could be the major biochemical elements...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28212538/sevoflurane-preconditioning-induced-endogenous-neurogenesis-against-ischemic-brain-injury-by-promoting-microglial-activation
#9
Li Li, Hexige Saiyin, Jingmo Xie, Lixiang Ma, Lei Xue, Wei Wang, Weimin Liang, Qiong Yu
Brain ischemia causes irreversible damage to functional neurons in cases of infarct. Promoting endogenous neurogenesis to replace necrotic neurons is a promising therapeutic strategy for ischemia patients. The neuroprotective role of sevoflurane preconditioning implies that it might also enhance endogenous neurogenesis and functional restoration in the infarct region. By using a transient middle cerebral artery occlusion (tMCAO) model, we discovered that endogenous neurogenesis was enhanced by sevoflurane preconditioning...
April 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28190546/sevoflurane-attenuates-ischemia-reperfusion-injury-in-a%C3%A2-rat%C3%A2-lung%C3%A2-transplantation-model
#10
Akihiro Ohsumi, Katherine Marseu, Peter Slinger, Karen McRae, Hyunhee Kim, Zehong Guan, David M Hwang, Mingyao Liu, Shaf Keshavjee, Marcelo Cypel
BACKGROUND: Sevoflurane is one of the most commonly used volatile anesthetic agents with the fastest onset and offset, replacing isoflurane in modern anesthesiology. Preconditioning and postconditioning using volatile anesthetics can attenuate ischemia-reperfusion injury (IRI). However, no previous studies have evaluated the effect of sevoflurane in lung transplantation after cold ischemic injury. We aimed to study the effects of donor and recipient treatment with sevoflurane in a rat lung transplantation model...
May 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28135708/remote-ischaemic-preconditioning-and-sevoflurane-postconditioning-synergistically-protect-rats-from-myocardial-injury-induced-by-ischemia-and-reperfusion-partly-via-inhibition-tlr4-myd88-nf-%C3%AE%C2%BAb-signaling-pathway
#11
Jiru Zhang, Jing Zhang, Peng Yu, Min Chen, Qingfeng Peng, Zhiqiang Wang, Nan Dong
BACKGROUND/AIMS: A combination sevoflurane postconditioning (SPC) and remote ischemic preconditioning (RIPC) is proved effective in an ex vivo rat heart perfusion model. However, the combined effect of those two interventions is not tested in rat myocardial ischemia/reperfusion (I/R) model, and the underlying mechanisms remain to be elucidated. This study aimed to investigate the effect in vivo using a rat myocardial I/R model and illuminate the related mechanisms. METHODS: Forty male Sprague-Dawley rats were randomly divided into the following 5 groups: i) sham-operated control; ii) I/R; iii) I/R + RIPC; iv) I/R + SPC; v) I/R + RIPC + SPC...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28067701/economic-evaluation-of-pharmacologic-pre-and-postconditioning-with-sevoflurane-compared-with-total-intravenous-anesthesia-in-liver-surgery-a-cost-analysis
#12
RANDOMIZED CONTROLLED TRIAL
Klaus Eichler, Martin Urner, Claudia Twerenbold, Sabine Kern, Urs Brügger, Donat R Spahn, Beatrice Beck-Schimmer, Michael T Ganter
BACKGROUND: Pharmacologic pre- and postconditioning with sevoflurane compared with total IV anesthesia in patients undergoing liver surgery reduced complication rates as shown in 2 recent randomized controlled trials. However, the potential health economic consequences of these different anesthesia regimens have not yet been assessed. METHODS: An expostcost analysis of these 2 trials in 129 patients treated between 2006 and 2010 was performed. We analyzed direct medical costs for in-hospital stay and compared pharmacologic pre- and postconditioning with sevoflurane (intervention) with total IV anesthesia (control) from the perspective of a Swiss university hospital...
March 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28045693/kelch-like-ech-associated-protein-1-dependent-nuclear-factor-e2-related-factor-2-activation-in-relation-to-antioxidation-induced-by-sevoflurane-preconditioning
#13
Min Cai, Li Tong, Beibei Dong, Wugang Hou, Likai Shi, Hailong Dong
BACKGROUND: The authors have reported that antioxidative effects play a crucial role in the volatile anesthetic-induced neuroprotection. Accumulated evidence shows that endogenous antioxidation could be up-regulated by nuclear factor-E2-related factor 2 through multiple pathways. However, whether nuclear factor-E2-related factor 2 activation is modulated by sevoflurane preconditioning and, if so, what is the signaling cascade underlying upstream of this activation are still unknown. METHODS: Sevoflurane preconditioning in mice was performed with sevoflurane (2...
March 2017: Anesthesiology
https://www.readbyqxmd.com/read/27830025/sevoflurane-postconditioning-improves-myocardial-mitochondrial-respiratory-function-and-reduces-myocardial-ischemia-reperfusion-injury-by-up-regulating-hif-1
#14
Long Yang, Peng Xie, Jianjiang Wu, Jin Yu, Tian Yu, Haiying Wang, Jiang Wang, Zhengyuan Xia, Hong Zheng
BACKGROUND: Sevoflurane postconditioning (SPostC) can exert myocardial protective effects similar to ischemic preconditioning. However, the exact myocardial protection mechanism by SPostC is unclear. Studies indicate that hypoxia-inducible factor-1 (HIF-1) maintains cellular respiration homeostasis by regulating mitochondrial respiratory chain enzyme activity under hypoxic conditions. This study investigated whether SPostC could regulate the expression of myocardial HIF-1α and to improve mitochondrial respiratory function, thereby relieving myocardial ischemia-reperfusion injury in rats...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27800510/sevoflurane-mitigates-shedding-of-hyaluronan-from-the-coronary-endothelium-also-during-ischemia-reperfusion-an-ex-vivo-animal-study
#15
Congcong Chen, Daniel Chappell, Thorsten Annecke, Peter Conzen, Matthias Jacob, Ulrich Welsch, Bernhard Zwissler, Bernhard F Becker
Glycosaminoglycan hyaluronan (HA), a major constituent of the endothelial glycocalyx, helps to maintain vascular integrity. Preconditioning the heart with volatile anesthetic agents protects against ischemia/reperfusion injury. We investigated a possible protective effect of sevoflurane on the glycocalyx, especially on HA. The effect of pre-ischemic treatment with sevoflurane (15 minutes at 2% vol/vol gas) on shedding of HA was evaluated in 28 isolated, beating guinea pig hearts, subjected to warm ischemia (20 minutes at 37°C) followed by reperfusion (40 minutes), half with and half without preconditioning by sevoflurane...
2016: Hypoxia
https://www.readbyqxmd.com/read/27780142/sevoflurane-protects-against-hepatic-ischemia-reperfusion-injury-by-modulating-microrna-200c-regulation-in-mice
#16
Yamou Wu, Chengyong Gu, Xiaochen Huang
This present study was aimed to investigate the molecular mechanisms involved in sevoflurane protection of hepatic ischemia-reperfusion (I/R) injury. Firstly, we investigated the protective effects of sevoflurane against hepatic I/R injury. Biochemical analysis results showed that sevoflurane preconditioning significantly protected against hepatic I/R injury by reducing liver enzymes and improving antioxidant defense markers. We also found that sevoflurane attenuates I/R-induced hepatic cell death, by TUNEL staining, DNA fragmentation ELISA and PARP activity determination...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27737678/effect-of-helium-pre-or-postconditioning-on-signal-transduction-kinases-in-patients-undergoing-coronary-artery-bypass-graft-surgery
#17
Kirsten F Smit, Daniel Brevoord, Stefan De Hert, Bas A de Mol, Raphaela P Kerindongo, Susan van Dieren, Wolfgang S Schlack, Markus W Hollmann, Nina C Weber, Benedikt Preckel
BACKGROUND: The noble gas helium induces pre- and postconditioning in animals and humans. Volatile anesthetics induce cardioprotection in humans undergoing coronary artery bypass graft (CABG) surgery. We hypothesized that helium induces pre- and postconditioning in CABG-patients, affecting signaling molecules protein kinase C-epsilon (PKC-ε), p38 mitogen activated protein kinase (p38 MAPK), extracellular signal-regulated kinase 1/2 (ERK-1/2) and heat shock protein 27 (HSP-27) within cardiac tissue, and reducing postoperative troponin levels...
October 14, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27549313/protective-effect-of-sevoflurane-preconditioning-on-ischemia-reperfusion-injury-in-patients-undergoing-reconstructive-plastic-surgery-with-microsurgical-flap-a-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Claudia Claroni, Giulia Torregiani, Marco Covotta, Maria Sofra, Alessandra Scotto Di Uccio, Maria E Marcelli, Alessia Naccarato, Ester Forastiere
BACKGROUND: In many clinical conditions that involve free flaps and tissue transplantations the possibility of minimizing ischemia-reperfusion injury can be a determinant factor for the success of the surgery itself. We hypothesize that preconditioning with sevoflurane is a protective factor against ischemia-reperfusion injury. METHODS: In this randomized controlled trial, patients ASA I-II undergoing breast reconstruction with deep inferior epigastric perforator flaps were allocated into two groups and analyzed: group BAL included patients who received balanced anesthesia with sevoflurane for 30 min before removal of the flap and throughout the surgery...
August 22, 2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/27531076/sevoflurane-preconditioning-in-on-pump-coronary-artery-bypass-grafting-a-meta-analysis-of-randomized-controlled-trials
#19
Yan Lu, Liwei Wang, Na Liu, Tianxin Dong, Ruhong Li
PURPOSE: Sevoflurane preconditioning (SevoPreC) has been proved to prevent organ ischemia/reperfusion (I/R) injury in various animal models and preclinical studies. Clinical trials on cardioprotection by SevoPreC for adult patients undergoing coronary artery bypass graft (CABG) revealed mixed results. The aim of this meta-analysis was to evaluate the cardiac effect of SevoPreC in on-pump CABG. METHODS: Randomized controlled trials (RCT) comparing the cardiac effect of SevoPreC (compared with control) in adult patients undergoing CABG were searched from PubMed, Embase, and the Cochrane Library (up to November 2015)...
December 2016: Journal of Anesthesia
https://www.readbyqxmd.com/read/27275856/sevoflurane-preconditioning-during-myocardial-ischemia-reperfusion-reduces-infarct-size-and-preserves-autonomic-control-of-circulation-in-rats
#20
Rubens Campana Pasqualin, Cristiano Teixeira Mostarda, Leandro Ezequiel de Souza, Matheus Fachini Vane, Raquel Sirvente, Denise Aya Otsuki, Marcelo Luís Abramides Torres, Maria Cláudia Costa Irigoyen, José Otávio Costa Auler
PURPOSE: To investigate the myocardial ischemia-reperfusion with sevoflurane anesthetic preconditioning (APC) would present beneficial effects on autonomic and cardiac function indexes after the acute phase of a myocardial ischemia-reperfusion. METHODS: Twenty Wistar rats were allocated in three groups: control (CON, n=10), myocardial infarction with sevoflurane (SEV, n=5) and infarcted without sevoflurane (INF, n=5). Myocardial ischemia (60 min) and reperfusion were performed by temporary coronary occlusion...
May 2016: Acta Cirúrgica Brasileira
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