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sevoflurane kidney transplant

G J Nieuwenhuijs-Moeke, V B Nieuwenhuijs, M A J Seelen, S P Berger, M C van den Heuvel, J G M Burgerhof, P J Ottens, R J Ploeg, H G D Leuvenink, M M R F Struys
Background: Kidney transplantation is associated with harmful processes affecting the viability of the graft. One of these processes is associated with the phenomenon of ischaemia-reperfusion injury. Anaesthetic conditioning is a widely described strategy to attenuate ischaemia-reperfusion injury. We therefore conducted the Volatile Anaesthetic Protection of Renal Transplants-1 trial, a pilot project evaluating the influence of two anaesthetic regimens, propofol- vs sevoflurane-based anaesthesia, on biochemical and clinical outcomes in living donor kidney transplantation...
May 1, 2017: British Journal of Anaesthesia
M S Karadeniz, H S Ciftci, T Tefik, O Mammadov, H Yazıcı, I Nane, A Turkmen, F Oguz, K M Tugrul
BACKGROUND: Anesthetic management of patients during renal transplantation is vitally important for ensuring proper functioning of kidneys that have undergone ischemia-reperfusion damage. The goal of this prospective study was to compare the effects of 2 different inhalation agents (sevoflurane and desflurane) on grafted kidney function in renal transplantation surgery. METHODS: Sixty-five patients who were scheduled for living donor renal transplantation were enrolled in the study...
April 2017: Transplantation Proceedings
Jelka Masin-Spasovska, Koco Dimitrovski, Sotir Stavridis, Oliver Stankov, Saso Dohcev, Skender Saidi, Krume Jakovski, Trajan Balkanov, Nikola Labacevski, Viktor Stankov, Ljupco Lekovski, Goce Spasovski
INTRODUCTION: A liver dysfunction induced by halogenated volatile anaesthetics is considered as a significant diagnostic problem. The aim of our report was to describe the first case of lethal hepatic failure in a female patient undergoing kidney transplantation (KTx) from a living donor after repeated sevoflurane anaesthesia. CASE PRESENTATION: A 47-year-old hypertensive and diabetic female patient received kidney from her 70-year-old mother. There was an immediate graft function and around 800 ml of blood loss on the abdominal drains, which gradually decreased after the erythrocyte and fresh frozen plasma (FFP) substitution...
April 2013: Current Drug Safety
V V Lazarev, K G Salmasi, L E Tsypin, V S Kochkin, A L Valov, D B Ectov
RESEARCH OBJECTIVE: To compare haemodynamic effects of general anaesthesia in combination with epidural block and without it during kidney transplantation in Pediatric patients. METHODS: 61 Pediatric patients undergoing kidney transplantation were divided into two groups. General anaesthesia with sevoflurane, propofol, phentanilum and regional ropivacaine epidural block were used in the group 1. General anaesthesia was used only in the group 2. Haemodynamic parameters were assessed: Arterial blood pressure, stroke volume, central venous pressure and cardiac index...
January 2013: Anesteziologiia i Reanimatologiia
J H Lee, D J Joo, J M Kim, J H Park, Y S Kim, B N Koo
BACKGROUND: In living donor kidney transplantation (LDKT), we evaluated if there was any difference in grafted kidney function according to the type of anesthetic used in the donor because some laboratory studies have demonstrated that volatile anesthetics at clinically relevant concentrations protect the kidneys against renal ischemia-reperfusion injury. METHODS: In part I of the study, we retrospectively compared grafted kidney function [serum creatinine levels (Cr) and estimated glomerular filtration rates (eGFR) in recipients of LDKT] according to the type of donors' volatile anesthetic (sevoflurane [group Sevo, 166 patients], isoflurane [group Iso, 55] or desflurane [group Des, 61])...
May 2013: Minerva Anestesiologica
Jin Ha Park, Jae Hoon Lee, Dong Jin Joo, Ki Jun Song, Yu Seun Kim, Bon-Nyeo Koo
BACKGROUND: The objective of this retrospective study was to determine if there are any differences in grafted kidney function in recipients of kidney transplantation (KT) when donors and recipients were anesthetized with sevoflurane compared to desflurane. METHODS: Seventy-three pairs of donors-recipients were anesthetized with sevoflurane (Sevo group) and 71 pairs were anesthetized with desflurane (Des group). We retrospectively investigated the blood urea nitrogen (BUN) levels, creatinine (Cr) levels, and estimated glomerular filtration rates (eGFR) of the recipients in both groups for 1 year postoperatively...
June 2012: Korean Journal of Anesthesiology
B Alonso Menárguez, L Gajate Martín, J García Suárez, A Martín Martín, R Moreno Ballesteros, P Arribas Pérez, J García Fernández
OBJECTIVE: To compare the post-operative effects of sevoflurane versus propofol on liver and kidney function while maintaining anaesthesia in the orthotopic liver transplant (OLT), as well as to analyse the short-term survival as regards these functions. PATIENTS AND METHODS: A retrospective analysis was conducted on patients subjected to an OLT between January 2002 and December 2009. Patients on pre-transplant haemodialysis, re-transplants, and hepatorenal transplants were excluded...
May 2012: Revista Española de Anestesiología y Reanimación
H Y Kong, S M Zhu, L Q Wang, Y He, H Y Xie, S S Zheng
BACKGROUND: Living donor liver transplantation (LDLT) patients run the risk of developing acute kidney injury (AKI) and subsequent chronic kidney disease, affecting morbidity and mortality. Sevoflurane has anti-inflammation properties, and renal ischemia/reperfusion under sevoflurane anesthesia resulted in drastic improvements in renal function. Extrahepatic metabolism of sevoflurane has been reported in patients undergoing liver transplantation, and might lead to nephrotoxicity. However, whether sevoflurane anesthesia is safe with regard to renal function in small-size liver transplantation needs further investigation...
2010: American Journal of Nephrology
Kazuyoshi Hashimoto, Yoshiki Ozawa, Ai Tsurutani, Tomoharu Kobayashi, Shuichirou Matsumoto, Keimei Kojima, Makoto Mannami
BACKGROUND: We used fentanyl and remifentanil in living-donor renal transplantation patients. So, we have compared both drugs in renal function. METHODS: We used the volatile anesthetic sevoflurane as the base in 30 living-donor renal transplantation patients, dividing them into a remifentanil anesthesia group of 15 patients and a fentanyl anesthesia group of 15 patients, and compared their creatinine, BUN, and serum K values before surgery, and 1 day as well as 3 days after surgery...
August 2010: Masui. the Japanese Journal of Anesthesiology
P Jason Toppin, Tony T Chandy, Anand Ghanekar, Natalia Kraeva, W Scott Beattie, Sheila Riazi
PURPOSE: To report the identification of a novel mutation in the CACNA1S gene that encodes the alpha-1-subunit (Cav1.1) of the voltage-gated skeletal muscle L-type calcium channel in a patient with malignant hyperthermia. CLINICAL FINDINGS: An otherwise healthy 34-yr-old female developed fulminant malignant hyperthermia (MH) under sevoflurane anesthesia during laparoscopic donor nephrectomy. The first sign was an increase in end-tidal CO(2). Malignant hyperthermia was suspected early, and resuscitative measures, including supportive and specific treatment, were successfully implemented...
July 2010: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
Kazuyoshi Hashimoto, Yoshiki Ozawa, Ai Tsurutani, Tomoharu Kobayashi, Keimei Kojima, Makoto Mannami
A 52-year-old man with mitochondorial encephalomyopathy was scheduled for renal transplantation from a living donor. He had some characteristic features including muscle weakness, deafness, cerebellar ataxia, diabetes meritus and renal failure. Anesthesia was induced with bolus infusion of propofol 1 mg x kg(-1) and continuous infusion of remifentanil at 0.15 microg x kg(-1) x min(-1) was started. After supporting ventilation for three minutes, the trachea was intubated without any muscle relaxant. Anesthesia was maintained with sevoflurane (0...
May 2009: Masui. the Japanese Journal of Anesthesiology
N Iu Biriulina, I A Ushakova, A V Vabishchevich
For many children with severe renal excretory dysfunction, renal transplantation is the sole method of life prolongation. The purpose of the investigation was to analyze the specific features of anesthetic maintenance of transplantation of related and cadaver kidney at 1 to 5 years. The investigation involved a detailed analysis of the specific features of 101 anesthesias made in children aged 1 to 16 years (mean 9.6+/-4.87 years) during transplantation of kidneys from corpses and apparently healthy relatives...
September 2008: Anesteziologiia i Reanimatologiia
S Teixeira, G Costa, F Costa, J da Silva Viana, A Mota
UNLABELLED: Different inhalational anesthetics have various hemodynamic effects, either on the global circulation or on kidney perfusion. These drugs are also different concerning their potential for renal toxicity. The potential influence of the choice of the halogenated anesthetion in the outcome of kidney transplantation has not been previously studied, which was the purpose of this observational study. METHODS: We examined the hospital records and anesthesiology charts of 200 patients undergoing renal transplantation using general anesthesia...
October 2007: Transplantation Proceedings
M Kanbak, A H Karagoz, N Erdem, B Oc, F Saricaoglu, N Ertas, A Berkkan, O Abbasoglu, U Aypar
BACKGROUND: The main metabolic pathway for defluorination of sevoflurane in the liver produces inorganic fluoride (Fl). The metabolism and effect of sevoflurane on the kidney is not clear during anhepatic phase in liver transplantation. The goal of the present study was to investigate the metabolism and renal effect of sevoflurane by measuring plasma and urine inorganic fluoride, urinary N-acetyl-glucosaminidase (NAG), and plasma creatinine levels in patients undergoing liver transplantations...
June 2007: Transplantation Proceedings
P Colson
The nephrotoxicity of anaesthesia remains a current question with the use of low-flow sevoflurane anaesthesia, although the issue of clinically relevant toxicity in patients with renal disease has not been evaluated. With regard to kidney transplantation, the type of fluid administered for volume management of organ donors appears crucial to improve postoperative recovery of renal function.
June 1998: Current Opinion in Anaesthesiology
N Erdem, M Kanbak, F Saricaoglu, T Ocal, C Tanyel, N Ertaş, A Berkkan, U Aypar
In a case of liver transplantation, sevoflurane metabolism was studied to investigate if sevoflurane has an extrahepatic metabolism or possible nephrotoxicity in the presence of chronic liver disease. Plasma blood urea nitrogen (BUN) and creatinine and urine levels of N-acetyl glycosaminidase (NAG) and beta2 microglobulin were assessed intraoperatively and for 11 days postoperatively. We observed a close relation between urine NAG excretion and urine inorganic fluoride levels in the intraoperative period and early postoperative days...
June 2006: Transplantation Proceedings
Kaori Yoshitomi, Yasuhiro Morimoto, Kazuyoshi Ishida, Masako Mii, Yasutaka Shinjo, Takefumi Sakabe
A 25-year-old female underwent renal transplantation. The patient had no complication preoperatively except hypertension. Preoperative electrocardiogram revealed no abnormality. Anesthesia was maintained with sevoflurane. Donor kidney was perfused with University of Wisconsin (UW)'s solution (4 degrees C) after removal. Transient complete atrioventricular block appeared twice after reperfusion of the transplanted kidney. Adenosine in the UW's solution was considered the major cause of atrioventricular block in this patient...
June 2002: Masui. the Japanese Journal of Anesthesiology
G Della Rocca, M G Costa, K Bruno, C Coccia, L Pompei, P Di Marco, R Pretagostini, M Colonnello, M Rossi, P Pietropaoli, R Cortesini
The appropriate choice of anesthesia for patients (pts) undergoing renal transplantation (Ktx) requires minimal toxicity and accurate monitoring for pts at high risk for metabolic, cardiovascular, and respiratory perioperative complications. We evaluated the anesthetic management and postoperative follow-up in pediatric Ktx performed in the last 12 years in our institution. From 1988 to 1999, 75 ASA class II-III pts (45 males, 22 females) younger than 18 years scheduled for Ktx were studied: 49 received a graft from a cadaveric donor (CD) and 26 from a living donor (LD)...
March 2001: Pediatric Surgery International
R Okutani, Y Uemura, M Tanimoto, H Kurehara, A Fukushima
We gave general anesthesia using sevoflurane to a patient undergoing cadaveric renal transplantation. Although the maximum inorganic fluoride concentration in the serum was unexpectedly high (74 uM) in the perioperative period, urine output from the transplanted kidney started simultaneously with reperfusion of the kidney and renal functions also recovered swiftly. Enzyme induction caused by anticonvulsants, which had been administered prior to operation, was assumed to be the cause of the elevation in serum inorganic fluoride concentrations in the patient...
July 1999: Masui. the Japanese Journal of Anesthesiology
A A Artru
In 32 published reports in surgical patients, the preponderance of evidence from standard clinical measures of renal function (BUN and Cr) indicates the absence of renal toxicity following sevoflurane anesthesia. Studies of surgical patients receiving intermediate-duration sevoflurane with high or low fresh gas flow and long-duration sevoflurane with high fresh gas flow included sensitive measures of renal function and/or injury, which also indicate the absence of renal toxicity following sevoflurane anesthesia...
November 1998: Journal of Clinical Anesthesia
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