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https://www.readbyqxmd.com/read/29153067/-detection-of-influenza-virus-infections-by-molecular-and-immunofluorescence-methods
#1
Deniz Yıldırım, Deniz Özdoğru Sağdıç, Buket Şeflek, Mehmet Çimentepe, İbrahim Bayram, Fügen Yarkın
Influenza virus infections are extremely important for human health due to the occurence of seasonal epidemics and pandemics worldwide. Influenza is associated with high morbidity and may result in serious complications such as life threatening viral or bacterial pneumonia. Especially, young children, older adults, patients with chronic diseases such as heart, lung, kidney, and diabetes and immunosuppressed people are at higher risk for complications and death from influenza virus infections. The aim of this study was to determine the incidence of influenza type A and B virus infections and influenza A virus subtypes in hospitalized patients with respiratory tract infections by real-time reverse transcriptase-polymerase chain reaction (RT-PCR, Sacace, Italy), conventional RT-PCR and direct immunofluorescence antibody (DFA, Argene SA, France) tests...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29110865/establishing-a-cohort-in-a-developing-country-experiences-of-the-diabetes-tuberculosis-treatment-outcome-cohort-study
#2
Fatima Mukhtar, Zahid A Butt
BACKGROUND: Prospective cohort studies are instrumental in generating valid scientific evidence based on identifying temporal associations between cause and effect. Researchers in a developing country like Pakistan seldom undertake cohort studies hence little is known about the challenges encountered while conducting them. We describe the retention rates among tuberculosis patients with and without diabetes, look at factors associated with loss to follow up among the cohort and assess operational factors that contributed to retention of cohort...
December 2017: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/29095851/a-non-invasive-risk-score-for-predicting-incident-diabetes-among-rural-chinese-people-a-village-based-cohort-study
#3
Jiangping Wen, Jie Hao, Yuanbo Liang, Sizhen Li, Kai Cao, Xilin Lu, Xinxin Lu, Ningli Wang
OBJECTIVE: To develop a new non-invasive risk score for predicting incident diabetes in a rural Chinese population. METHODS: Data from the Handan Eye Study conducted from 2006-2013 were utilized as part of this analysis. The present study utilized data generated from 4132 participants who were ≥30 years of age. A non-invasive risk model was derived using two-thirds of the sample cohort (selected randomly) using stepwise logistic regression. The model was subsequently validated using data from individuals from the final third of the sample cohort...
2017: PloS One
https://www.readbyqxmd.com/read/29094528/care-of-older-people-with-diabetes
#4
Trisha Dunning
The global population is ageing, and increasingly developing long-term conditions and comorbidities associated with functional changes, reduced quality of life and reduced life expectancy. Diabetes mellitus is a common long-term condition in older people, with many individuals experiencing microvascular and/or macrovascular complications, alongside frailty and dementia. Symptoms of conditions such as hypoglycaemia and hyperglycaemia may change as a result of older age and long duration of, and complications associated with, diabetes; therefore, such symptoms can be challenging to recognise in older people...
September 13, 2017: Nursing Standard
https://www.readbyqxmd.com/read/29091128/self-care-competence-in-the-administration-of-insulin-in-older-people-aged-70-or-over1
#5
Mayara Sousa Vianna, Patrícia Aparecida Barbosa Silva, Cíntia Vieira do Nascimento, Sônia Maria Soares
OBJECTIVE: to analyze the self-care competence in the administration of insulin performed by older people aged 70 or over. METHOD: cross-sectional study carried out with 148 older people aged 70 or over, who performed self-administration of insulin. Data collection was carried out using a structured questionnaire and an adapted guide for the application of the Scale to Identify Self-Care Competence of Patients with Diabetes, at the participants' home. Data analysis included descriptive and inferential statistical tests, with forward logistic regression...
October 30, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29083449/high-serum-folate-is-associated-with-brain-atrophy-in-older-diabetic-people-with-vitamin-b12-deficiency
#6
Y Deng, D Wang, K Wang, T Kwok
Previous studies have reported the adverse cognitive effects of high folate status in older individuals with vitamin B12 (VB12) deficiency. Thus, the aim of this study was to investigate how high serum folate and VB12 deficiency could collaboratively aggravate neuronal degeneration. In total, 146 older non-demented diabetic individuals with an average age of 75 ± 3.9 were recruited. VB12 deficiency and high folate status were based on high serum methylmalonic acid (MMA) concentrations (> 0.3 μmol/L) and the serum folate concentration being in the top tertile (> 31...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29079827/impact-of-hypertension-versus-diabetes-on-cardiovascular-and-all-cause-mortality-in-iranian-older-adults-results-of-14-years-of-follow-up
#7
Neda Zafari, Samaneh Asgari, Mojtaba Lotfaliany, Amirreza Hadaegh, Fereidoun Azizi, Farzad Hadaegh
To evaluate the joint effect of hypertension (HTN) and diabetes (DM) on coronary heart disease (CHD), and stroke event, all-cause, and cardiovascular disease (CVD) mortality in Middle Eastern older adults, 2747 people (1436 women) aged ≥ 50 years, free of CVD at baseline, were categorized into four groups (HTN-/DM-, HTN+/DM-, HTN-/DM+, HTN+/DM+). Multivariate Cox proportional hazard models were run for different outcomes. To compare the impact of HTN versus DM, HTN+/DM- was considered as reference. In a median of 13...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29079032/association-between-accumulation-of-advanced-glycation-end-products-and-hearing-impairment-in-community-dwelling-older-people-a-cross-sectional-sukagawa-study
#8
Kakuya Niihata, Sei Takahashi, Noriaki Kurita, Nobuyuki Yajima, Kenji Omae, Shingo Fukuma, Takayuki Okano, Yukio Nomoto, Koichi Omori, Shunichi Fukuhara
OBJECTIVES: The experimental studies suggested the hypothesis that the accumulation of advanced glycation end-products (AGEs) could induce hearing impairment. The purpose of this study is to examine the hypothesis among elderly people using an epidemiologic approach. DESIGN: Cross-sectional study. SETTING: Sukagawa City, Fukushima, Japan. PARTICIPANTS: A total of 270 residents aged 75 years or over without dementia, who participated in a health check-up conducted in 2015...
October 24, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29078781/physical-chronic-conditions-multimorbidity-and-sedentary-behavior-amongst-middle-aged-and-older-adults-in-six-low-and-middle-income-countries
#9
Davy Vancampfort, Brendon Stubbs, Ai Koyanagi
BACKGROUND: Sedentary behavior (SB) is, irrespective of a person's physical activity levels, associated with a wide range of deleterious outcomes such as diabetes, stroke and associated premature mortality. There are no nationally representative, multi-national, population-based studies investigating the relationship between SB, chronic conditions, and physical multimorbidity (i.e., two or more chronic physical conditions). Thus, this cross-sectional study aimed to assess the association between chronic conditions, physical multimorbidity and SB among community-dwelling adults in six low- and middle-income countries (LMICs)...
October 27, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29067239/differences-between-genders-in-relation-to-factors-associated-with-risk-of-diabetic-foot-in-elderly-persons-a-cross-sectional-trial
#10
Fabiana Magalhães Navarro-Peternella, Ana Patrícia A Torquato Lopes, Guilherme Oliveira de Arruda, Elen Ferraz Teston, Sonia Silva Marcon
AIMS: This trial aims to identify differences between genders in relation to factors associated with the risk of diabetic foot in elderly persons. METHODS: We evaluated 187 older adults diagnosed with diabetes type 2. The variables investigated were sociodemographic data, clinical history of diabetes mellitus and complaints about the feet. The plantar sensitivity was evaluated on both feet, with the use of Semmes-Weinstein monofilaments. For data analysis we used chi-square test and binary logistic regression (p < 0...
December 2016: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29065431/liver-fat-content-in-people-with-pituitary-diseases-influence-of-serum-igf1-levels
#11
Amandine Nguyen, Fréderic Ricolfi, Brivel Lemogne, Serge Aho, Stéphanie Lemaire, Benjamin Bouillet, Laurence Duvillard, Damien Denimal, Coralie Fourmont, Romaric Loffroy, Jean Pierre Cercueil, Bruno Verges, Jean Michel Petit
Non-alcoholic fatty liver disease (NAFLD) is commonly associated with obesity, metabolic syndrome, and type 2 diabetes. NAFLD is also seen in patients with endocrinopathies. However, the relationship between endocrine diseases and the development of NAFLD is not well known. In this study, we set out to determine whether liver fat content (LFC) was associated with IGF1 levels in people with pituitary diseases (PD). Eighty-nine patients with pituitary diseases and 74 healthy controls were included in this study...
October 24, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29064542/elevated-leukocyte-count-as-a-harbinger-of-systemic-inflammation-disease-progression-and-poor-prognosis-a-review
#12
Piotr Paweł Chmielewski, Bartłomiej Strzelec
Total leukocyte count increases significantly in response to infection, trauma, inflammation, and certain diseases. Factors affecting leukocyte count in healthy adults include sex, hormonal milieu, genetic inheritance, stress level, diet, nutrition, and lifestyle (e.g. tobacco-induced inflammatory changes, chronic psychological stress, etc.). To date, numerous studies have reported that high but normal leukocyte counts at baseline predict increased cardiovascular and noncardiovascular mortality in older adults...
October 24, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29061601/the-prevalence-of-non-communicable-diseases-in-northwest-ethiopia-survey-of-dabat-health-and-demographic-surveillance-system
#13
Solomon Mekonnen Abebe, Gashaw Andargie, Alemayehu Shimeka, Kassahun Alemu, Yigzaw Kebede, Mamo Wubeshet, Amare Tariku, Abebaw Gebeyehu, Mulugeta Bayisa, Mezgebu Yitayal, Tadesse Awoke, Temesgen Azmeraw, Melkamu Birku
OBJECTIVE: The main objective of this study was to investigate the magnitude and associated factors of non-communicable chronic diseases (NCDs) at the Dabat Health and Demographic Surveillance System (DHDSS) site in the northwestern part of Ethiopia. DESIGN: A population-based cross-sectional study was conducted from October to December 2014. SETTING: HDSS site, Ethiopia. PARTICIPANTS: A total population of 67 397 living in 16 053 households was included in the study...
October 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29047372/effectiveness-and-safety-of-dipeptidyl-peptidase-4-inhibitors-in-the-management-of-type-2-diabetes-in-older-adults-a-systematic-review-and-development-of-recommendations-to-reduce-inappropriate-prescribing
#14
REVIEW
Gisela Schott, Yolanda V Martinez, R Erandie Ediriweera de Silva, Anna Renom-Guiteras, Anna Vögele, David Reeves, Ilkka Kunnamo, Minna Marttila-Vaara, Andreas Sönnichsen
BACKGROUND: Preventable drug-related hospital admissions can be associated with drugs used in diabetes and the benefits of strict diabetes control may not outweigh the risks, especially in older populations. The aim of this study was to look for evidence on risks and benefits of DPP-4 inhibitors in older adults and to use this evidence to develop recommendations for the electronic decision support tool of the PRIMA-eDS project. METHODS: Systematic review using a staged approach which searches for systematic reviews and meta-analyses first, then individual studies only if prior searches were inconclusive...
October 16, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29047344/efficacy-and-safety-of-metformin-in-the-management-of-type-2-diabetes-mellitus-in-older-adults-a-systematic-review-for-the-development-of-recommendations-to-reduce-potentially-inappropriate-prescribing
#15
REVIEW
Lisa Schlender, Yolanda V Martinez, Charles Adeniji, David Reeves, Barbara Faller, Christina Sommerauer, Thekraiat Al Qur'an, Adrine Woodham, Ilkka Kunnamo, Andreas Sönnichsen, Anna Renom-Guiteras
BACKGROUND: Metformin is usually prescribed as first line therapy for type 2 diabetes mellitus (DM2). However, the benefits and risks of metformin may be different for older people. This systematic review examined the available evidence on the safety and efficacy of metformin in the management of DM2 in older adults. The findings were used to develop recommendations for the electronic decision support tool of the European project PRIMA-eDS. METHODS: The systematic review followed a staged approach, initially searching for systematic reviews and meta-analyses first, and then individual studies when prior searches were inconclusive...
October 16, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29045728/how-do-primary-care-doctors-in-england-and-wales-code-and-manage-people-with-chronic-kidney-disease-results-from-the-national-chronic-kidney-disease-audit
#16
Lois G Kim, Faye Cleary, David C Wheeler, Ben Caplin, Dorothea Nitsch, Sally A Hull
Background: In the UK, primary care records are electronic and require doctors to ascribe disease codes to direct care plans and facilitate safe prescribing. We investigated factors associated with coding of chronic kidney disease (CKD) in patients with reduced kidney function and the impact this has on patient management. Methods: We identified patients meeting biochemical criteria for CKD (two estimated glomerular filtration rates <60 mL/min/1.73 m2 taken >90 days apart) from 1039 general practitioner (GP) practices in a UK audit...
October 16, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29042249/prevalence-and-biochemical-risk-factors-of-diabetic-peripheral-neuropathy-with-or-without-neuropathic-pain-in-taiwanese-adults-with-type-2-diabetes-mellitus
#17
Yen-Wei Pai, Ching-Heng Lin, I-Te Lee, Ming-Hong Chang
AIMS: To investigate the prevalence and risk factors for diabetic peripheral neuropathy with or without neuropathic pain in Taiwanese. METHODS: A cross-sectional, hospital-based observational study was conducted. We enrolled 2837 adults with type 2 diabetes mellitus. Diabetic peripheral neuropathy with or without pain were diagnosed using 2 validated screening tools, namely the Michigan Neuropathy Screening Instrument and Douleur Neuropathique 4 questionnaire. RESULTS: In our sample, 2233 participants had no neuropathy, 476 had diabetic peripheral neuropathy without pain, and 128 had diabetic peripheral neuropathy with neuropathic pain, representing an overall diabetic peripheral neuropathy prevalence of 21...
September 28, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29040166/measurement-of-retinal-vessels-as-a-biomarker-of-cerebrovascular-ageing-in-older-hiv-positive-men-compared-to-controls
#18
Lewis Haddow, Rosanna Laverick, Irene Leung, Frank Post, Jaime Vera, Richard Gilson, Ian Williams, Marta Boffito, Caroline Sabin, Alan Winston, Tunde Peto
BACKGROUND: To compare retinal vascular measurements, biomarkers of cerebral small vessel disease (SVD), in HIV positive men aged 50 years and above with similarly-aged HIV negative men and younger HIV positive men. METHODS: We recruited white, non-diabetic men to a cross-sectional substudy of a larger cohort including three demographically-matched groups. Optic disc centred 45° colour fundus photographs were used to calculate central retinal arterial and venous calibre and the arterial-venous ratio (AVR)...
October 14, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29037269/prevalence-of-prediabetes-and-modifiable-factors-in-an-ethnic-group-of-mexico-the-comc%C3%A3-ac-project
#19
Monica Daniela Robles-Ordaz, Ana Cristina Gallegos-Aguilar, Rene Urquidez-Romero, Rolando Giovanni Diaz-Zavala, Marcos Gerardo Lavandera-Torres, Julian Esparza-Romero
OBJECTIVE: To determine the prevalence of and modifiable factors associated with prediabetes in the Comcáac Indians. DESIGN: Cross-sectional study where prediabetes was defined using fasting plasma glucose, 2 h plasma glucose and glycated Hb (HbA1c). Physical, anthropometric and biochemical measurements, medical record, socio-economic, dietary and physical activity information were collected. The modifiable factors associated with prediabetes were assessed using multiple logistic regression...
October 17, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29037162/feasibility-of-a-multi-modal-exercise-program-on-cognition-in-older-adults-with-type-2-diabetes-a-pilot-randomised-controlled-trial
#20
M L Callisaya, R M Daly, J E Sharman, D Bruce, T M E Davis, T Greenaway, M Nolan, R Beare, M G Schultz, T Phan, L C Blizzard, V K Srikanth
BACKGROUND: Type 2 Diabetes (T2D) is associated with increased risk of dementia. We aimed to determine the feasibility of a randomised controlled trial (RCT) examining the efficacy of exercise on cognition and brain structure in people with T2D. METHODS: A 6-month pilot parallel RCT of a progressive aerobic- and resistance-training program versus a gentle movement control group in people with T2D aged 50-75 years (n = 50) at the University of Tasmania, Australia...
October 16, 2017: BMC Geriatrics
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