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Bladder stretch injury

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https://www.readbyqxmd.com/read/26256887/expression-of-heat-shock-protein-27-correlates-with-actin-cytoskeletal-dynamics-and-contractility-of-cultured-human-bladder-smooth-muscle-cells
#1
Yongquan Wang, Zhiyong Xiong, Wei Gong, Peng Zhou, Qiubo Xie, Zhansong Zhou, Gensheng Lu
Heat shock protein 27 (HSP27) is one of the most important chaperone proteins that modulates smooth muscle contraction. Here we investigated the effects of HSP27 expression on cytoskeleton dynamics and contractile function of human bladder smooth muscle cells (BSMCs) in vitro. Cultured human BSMCs were transfected with lentiviral vectors expressing either HSP27 or HSP27-siRNAs. Normal BSMCs cells and cells transfected with the empty lentivirus were used as control. Cells were then cultured on Flexcell flexible membrane dishes and mechanical stretch (14...
October 15, 2015: Experimental Cell Research
https://www.readbyqxmd.com/read/25763108/missed-signs-of-autonomic-dysreflexia-in-a-tetraplegic-patient-after-incorrect-placement-of-urethral-foley-catheter-a-case-report
#2
Subramanian Vaidyanathan, Bakul M Soni, Tun Oo, Peter L Hughes, Gurpreet Singh
BACKGROUND: Autonomic dysreflexia is poorly recognised outside of spinal cord injury centres, and may result in adverse outcomes including mortality from delayed diagnosis and treatment. We present a spinal cord injury patient, who developed autonomic dysreflexia following incorrect placement of urethral Foley catheter. Health professionals failed to recognise signs and symptoms of autonomic dysreflexia as well as its significance in this tetraplegic patient. CASE PRESENTATION: A tetraplegic patient started sweating profusely following insertion of a Foley catheter per urethra...
2014: Patient Safety in Surgery
https://www.readbyqxmd.com/read/25533254/-acute-urinary-retention-a-few-simple-rules-for-a-successful-catheterization
#3
REVIEW
Frédéric D Birkhäuser, Urs E Studer
Acute urinary retention is a common emergency condition in elderly men. Transurethral and suprapubic catheterization are easy and safe procedures provided that a few simple rules are followed. Primarily, a transurethral catheter is placed if there is no urethral injury or stricture. Local anaesthesia of the urethra up to the sphincter region and a well-stretched penis warrant an atraumatic insertion of the catheter into the bladder. The use of a thick catheter with a round tip or of a catheter with a bended tip under rectal guidance facilitate the insertion of the catheter in difficult conditions...
January 2015: Therapeutische Umschau. Revue Thérapeutique
https://www.readbyqxmd.com/read/23608618/the-effects-of-glivec-on-the-urinary-bladder-excitation-of-rats-with-suprasacral-or-sacral-spinal-cord-transection
#4
Jianping Deng, Yongge Zhang, Liang Wang, Jiang Zhao, Bo Song, Longkun Li
BACKGROUND: To investigate the effects of the c-kit blocker imatinib mesylate (Glivec) on the bladders of animals with suprasacral cord injury (SSCI) and sacral cord injury (SCI). MATERIALS AND METHODS: We randomized 60 female Sprague-Dawley rats into control, sham, SSCI (T8/9 transection), and SCI (S1-3 transection) groups. Six weeks later, we evaluated the effects of stepwise Glivec administrations on urinary bladder contraction using cystometry and the detrusor strip stretch-test...
August 2013: Journal of Surgical Research
https://www.readbyqxmd.com/read/23604449/-age-related-aspects-in-neurourology
#5
REVIEW
A Reitz, T Hüsch, A Haferkamp
This review highlights age-related aspects of neurogenic lower urinary tract dysfunction. The changing needs and requirements of elderly long-term paraplegics and of elderly people affected from acute spinal cord injury or neurological diseases are discussed. Complications and delayed damage in the urinary tract must be recognized in time to be treated successfully. For uro-oncological early recognition examinations and the assessment of screening parameters, disease and paralysis-associated aspects as well as the individual social situation must be considered...
June 2013: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/22712666/the-passive-and-active-contractile-properties-of-the-neurogenic-underactive-bladder
#6
John S Young, Louise Johnston, Camille Soubrane, Karen D McCloskey, Gordon McMurray, Rachel Eccles, Christopher H Fry
OBJECTIVE: To characterize passive and active changes in detrusor activity in a highly compliant bladder. MATERIALS AND METHODS: Bladders from adult female Sprague-Dawley rats were used 5 weeks after lower thoracic (T8) spinal cord transection or a sham-operation. Passive wall properties were assessed by pressure-volume relationships from whole bladders and the tensile response of bladder strips after a rapid (<0.5 s) stretch. Active properties were assessed from the frequency and amplitude of spontaneous contractions of bladder strips, and their response to the inotropic TRPV4 agonist GSK1016790A...
February 2013: BJU International
https://www.readbyqxmd.com/read/22310424/aberrant-iliac-artery-far-lateral-lumbosacral-surgical-anatomy
#7
Lawrence A Delasotta, Kris Radcliff, Marcos A Sonagli, Luciano Miller
A 44-year-old man presented after 3 weeks of progressively worsening atraumatic onset pain in the right anteromedial thigh. The pain was sharp and radiated to the anteromedial shin and medial foot. The patient had no associated weakness, numbness, or bowel/bladder dysfunction. Nonsteroidal anti-inflammatory, pain, and neuropathic-relieving drugs had limited effect. He underwent interlaminar injections, which provided transient relief of his shin symptoms. After conservative management failed, a spine surgeon (not affiliated with our practice) recommended an anterior lumbar interbody fusion via far lateral approach...
February 2012: Orthopedics
https://www.readbyqxmd.com/read/21495816/spine-shortening-osteotomy-for-patients-with-tethered-cord-syndrome-caused-by-lipomyelomeningocele
#8
Shoichi Kokubun, Hiroshi Ozawa, Toshimi Aizawa, Ngo Minh Ly, Yasuhisa Tanaka
OBJECTIVE: Tethered cord syndrome (TCS) is a disorder involving an abnormal stretching of the tethered spinal cord caused by several pathological conditions and presents with a variety of neurological symptoms. Untethering (tethered cord release) is the gold standard treatment for TCS. However, untethering carries risks of spinal cord injury and postoperative retethering. To avoid these potential risks, the authors applied spine-shortening osteotomy to adult patients with TCS, and report on the surgical procedure and treatment outcomes...
July 2011: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/21384200/strain-history-and-tgf-%C3%AE-1-induce-urinary-bladder-wall-smooth-muscle-remodeling-and-elastogenesis
#9
Rebecca L Heise, Aron Parekh, Erinn M Joyce, Michael B Chancellor, Michael S Sacks
Mechanical cues that trigger pathological remodeling in smooth muscle tissues remain largely unknown and are thought to be pivotal triggers for strain-induced remodeling. Thus, an understanding of the effects mechanical stimulation is important to elucidate underlying mechanisms of disease states and in the development of methods for smooth muscle tissue regeneration. For example, the urinary bladder wall (UBW) adaptation to spinal cord injury (SCI) includes extensive hypertrophy as well as increased collagen and elastin, all of which profoundly alter its mechanical response...
January 2012: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/21284372/scientific-basis-for-learning-transfer-from-movements-to-urinary-bladder-functions-for-bladder-repair-in-human-patients-with-cns-injury
#10
G Schalow
Coordination Dynamics Therapy (CDT) has been shown to be able to partly repair CNS injury. The repair is based on a movement-based re-learning theory which requires at least three levels of description: the movement or pattern (and anamnesis) level, the collective variable level, and the neuron level. Upon CDT not only the actually performed movement pattern itself is repaired, but the entire dynamics of CNS organization is improved, which is the theoretical basis for (re-) learning transfer. The transfer of learning for repair from jumping on springboard and exercising on a special CDT and recording device to urinary bladder functions is investigated at the neuron level...
November 2010: Electromyography and Clinical Neurophysiology
https://www.readbyqxmd.com/read/20869758/bilateral-hand-assisted-retroperitoneoscopic-nephroureterectomy-harn-in-the-spread-eagle-position-for-dialysis-patients-low-midline-harn-in-a-completely-supine-position
#11
Chien-Hui Ou, Wen-Horng Yang
OBJECTIVES: To evaluate the feasibility of hand-assisted bilateral retroperitoneoscopic nephroureterectomy (HARN) in a completely supine position (spread-eagle position [SEP]) for dialysis patients with bilateral upper urinary tract tumors. METHODS: From October 2006 to May 2009, bilateral HARN with open bladder cuff excisions were performed in 13 dialysis patients with upper urinary tract tumors. The patient was placed supine with both legs extended and abducted at 45-60 degrees and both arms stretched out to the sides in a SEP...
February 2011: Urology
https://www.readbyqxmd.com/read/20472895/an-akt-and-fra-1-dependent-pathway-mediates-platelet-derived-growth-factor-induced-expression-of-thrombomodulin-a-novel-regulator-of-smooth-muscle-cell-migration
#12
Aruna Ramachandran, Sandeep A Ranpura, Edward M Gong, Michelle Mulone, Glenn M Cannon, Rosalyn M Adam
Overdistension of hollow organs evokes pathological changes characterized by smooth muscle remodeling. Mechanical stimuli induce smooth muscle cell (SMC) growth through acute activation of signaling cascades and by increased expression of soluble mitogens. Physical forces have also been implicated in ligand-independent activation of receptor tyrosine kinases, including the platelet-derived growth factor (PDGF) receptor, although the extent to which this occurs in intact tissue is unknown. Previously, we implicated Akt and activator protein-1 (AP-1) as mediators of growth and gene expression in SMC exposed to cyclic stretch or PDGF...
July 2010: American Journal of Pathology
https://www.readbyqxmd.com/read/20433127/pelvic-organ-prolapse
#13
Indumathi Kuncharapu, Barbara A Majeroni, Dallas W Johnson
Pelvic organ prolapse, or genital prolapse, is the descent of one or more of the pelvic structures (bladder, uterus, vagina) from the normal anatomic location toward or through the vaginal opening. Women of all ages may be affected, although pelvic organ prolapse is more common in older women. The cause is a loss of pelvic support from multiple factors, including direct injury to the levator ani, as well as neurologic injury from stretching of the pudendal nerves that may occur with vaginal childbirth. Previous hysterectomy for pelvic organ prolapse; ethnicity; and an increase in intra-abdominal pressure from chronic coughing, straining with constipation, or repeated heavy lifting may contribute...
May 1, 2010: American Family Physician
https://www.readbyqxmd.com/read/20349554/phase-relation-changes-between-the-firings-of-alpha-and-gamma-motoneurons-and-muscle-spindle-afferents-in-the-sacral-micturition-centre-during-continence-functions-in-brain-dead-human-and-patients-with-spinal-cord-injury
#14
G Schalow
1. Single-nerve fibre action potentials (APs) were recorded with 2 pairs of wire electrodes from lower sacral nerve roots during surgery in patients with spinal cord injury and in a brain-dead human. Conduction velocity distribution histograms were constructed for afferent and efferent fibres, nerve fibre groups were identified and simultaneous impulse patterns of alpha and gamma-motoneurons and secondary muscle spindle afferents (SP2) were constructed. Temporal relations between afferent and efferent APs were analyzed by interspike interval (II) and phase relation changes to explore the coordinated self-organization of somatic and parasympathetic neuronal networks in the sacral micturition centre during continence functions under physiologic (brain-dead) and pathophysiologic conditions (spinal cord injury)...
January 2010: Electromyography and Clinical Neurophysiology
https://www.readbyqxmd.com/read/19990023/the-musculature-of-the-bladder-neck-of-the-male-in-health-and-disease-section-of-urology
#15
J B Macalpine
Two muscles, one voluntary the other involuntary, and an inch or more apart, exist at the bladder-neck, both functioning as sphincters. This dual musculature is explained by the emergence of the ejaculatory ducts between them. If both these muscles are open when semen is discharged, secretion may escape into the bladder or to the exterior; also any urine in the bladder would flow out. The internal sphincter is usually tightly contracted during ejaculation. Instances are given in which the internal sphincter is paralysed or injured, e...
November 1934: Proceedings of the Royal Society of Medicine
https://www.readbyqxmd.com/read/19845099/the-classification-and-identification-of-human-somatic-and-parasympathetic-nerve-fibres-including-urinary-bladder-afferents-and-efferents-is-preserved-following-spinal-cord-injury
#16
G Schalow
UNLABELLED: Single-fibre extracellular action potentials were recorded with 2 pairs of wire electrodes from lower human sacral nerve roots during surgery. The roots from which was recorded from were used for morphometry. Nerve fibre groups were identified by conduction velocity distribution histograms of single afferent and efferent fibres and partly by nerve fibre diameter distribution histograms. The values of group conduction velocity and group nerve fibre diameter measured in the paraplegics were very similar to those obtained from brain-dead humans and patients with no spinal cord injury...
September 2009: Electromyography and Clinical Neurophysiology
https://www.readbyqxmd.com/read/19827540/-urethrovesical-foreign-body-in-adolescent-boys-report-of-two-cases
#17
Masaomi Kuwada, Yoshitomo Chihara, Kazumasa Torimoto, Yoriaki Kagebayashi, Yasushi Nakai, Shoji Samma
Two cases with a urethrovesical foreign body in adolescent boys are reported. Case 1 was a 12-year-old boy with a stretched safety pin, 7 cm in length, in the urethra. This was probably introduced by him. Case 2 was a 14-year-old boy with a self-introduced metallic bar, 5 cm in length, in the urinary bladder. The foreign bodies were endoscopically removed. Both of the boys had grown in fatherless families. In Case 1, his father had died in a traffic accident while trying to save the patient at the age of 5 years...
September 2009: Nihon Hinyōkika Gakkai Zasshi. the Japanese Journal of Urology
https://www.readbyqxmd.com/read/19442007/clinical-study-of-reconstructed-bladder-innervation-below-the-level-of-spinal-cord-injury-to-produce-urination-by-achilles-tendon-to-bladder-reflex-contractions
#18
Haodong Lin, Chunlin Hou, Xianyou Zhen, Zhen Xu
OBJECT: Neurogenic bladder dysfunction following spinal cord injury (SCI) is a major medical and social problem for which there is no ideal treatment strategy. In the present study, the authors analyze the effectiveness of neurogenic bladder reinnervation in patients with SCIs by using Achilles tendon reflexes below the paraplegic level. METHODS: Spinal root anastomoses were performed in 12 paraplegic patients with hyperreflexic neurogenic bladder and detrusor external sphincter dyssynergia (DESD) caused by complete suprasacral SCI, in an attempt to reinnervate the bladder...
May 2009: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/18801531/hand-assisted-retroperitoneoscopic-nephroureterectomy-with-the-patient-spread-eagled-an-approach-through-a-completely-supine-position
#19
Chien-Hui Ou, Wen-Horng Yang
PURPOSE: We evaluated the feasibility of hand assisted retroperitoneoscopic nephroureterectomy for transitional cell carcinoma of the upper urinary tract with the patient completely supine (spread-eagled). MATERIALS AND METHODS: From October 2006 to January 2008 hand assisted retroperitoneoscopic nephroureterectomy with open bladder cuff excision was performed in 32 patients with upper tract transitional cell carcinoma. The patient was placed supine with the legs extended and abducted at 45 to 60 degrees, and the arms stretched out to the sides in the spread-eagle position...
November 2008: Journal of Urology
https://www.readbyqxmd.com/read/18793873/the-molecular-pathways-behind-bladder-stretch-injury
#20
REVIEW
Sarel Halachmi
Stretch injury is a non-reversible process that changes the cellular and extracellular characteristics of the bladder wall, leading to bladder dysfunction. Posterior urethral valve and neurogenic bladder are examples of disorders that may lead to stretch injury. There is a lack of understanding of the molecular processes leading to stretch injury. The current literature is reviewed in this paper, with the aim of giving some insight into the molecular and genetic pathways of bladder stretch injury.
February 2009: Journal of Pediatric Urology
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