Alessandro Di Minno, Hammad Ullah, Lorenza Francesca De Lellis, Daniele Giuseppe Buccato, Alessandra Baldi, Paola Cuomo, Hesham R El-Seedi, Shaden A M Khalifa, Xiang Xiao, Roberto Piccinocchi, Gaetano Piccinocchi, Roberto Sacchi, Maria Daglia
Preclinical studies have shown that the combination of Cistus × incanus L. and Scutellaria lateriflora L. extracts exerts beneficial effects on oral health against gingivitis. Thus, this study aimed to assess the tolerability of a chewing gum and its efficacy on gingivitis in a double-blind, placebo-controlled clinical trial. Enrolled subjects ( n = 60, 18-70 years) were randomized to receive two chewing gums or a placebo daily for 3 months. At baseline (t0) and monthly (t1, t2, and t3) timepoints, the Quantitative Gingival Bleeding Index (QGBI), the Modified Gingival Index (MGI), and the Oral Health 15 items (OH-15)] were employed to assess potential improvements in gingivitis...
March 16, 2024: Nutrients