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https://www.readbyqxmd.com/read/29666878/-methemoglobinemia-after-inhalation-of-poppers
#1
U Janssens, S Hillen, T Janssens, J Grafe
BACKGROUND: This case report presents a case of symptomatic methemoglobinemia (MetHb 31.6%) after inhalation of volatile nitrites (poppers). METHODS: The patient's medical history and symptoms are discussed together with pathophysiology of methemoglobinemia, diagnostics, and antidote therapy. Pulse oxymetry, arterial blood gas analysis, and CO-oximetry receive particular attention as well as antidote therapy with methylene blue. RESULTS: The patient was treated successfully with intravenous methylene blue...
April 17, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29580615/-sao-2-and-pao-2-mismatch-do-not-forget-hemoglobinopathy
#2
E Virot, S Hirschi, M Oswald, T Degot, M Canuet, A-C Galoisy, L Kiger, S Pissard, R Kessler
INTRODUCTION: Different clinico-biological parameters are used to estimate the amount of oxygen available for the organism. Oxygen saturation measured with pulse oxymetry (SpO2 ), oxygen saturation of arterial blood (SaO2 ) and oxygen partial pressure of the arterial blood (PaO2 ) are the most commonly used. CASE REPORT: We report the case of a patient admitted for investigation of respiratory failure in the context of chronic dyspnea of effort. SpO2 and SaO2 were decreased, though the PaO2 was normal...
March 23, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29532502/administering-atropine-and-ketamine-before-less-invasive-surfactant-administration-resulted-in-low-pain-scores-in-a-prospective-study-of-premature-neonates
#3
L Bourgoin, L Caeymaex, F Decobert, C Jung, C Danan, X Durrmeyer
AIM: Less invasive surfactant administration (LISA) can avoid tracheal intubation for neonatal respiratory distress syndrome, but can be painful because it requires laryngoscopy. The aim of this study was to assess the efficacy and tolerance of intravenous atropine plus ketamine administration before LISA. METHODS: We conducted a prospective observational study of all premature infants hospitalised in our French neonatal intensive care unit treated with LISA between March 2015 and March 2016...
March 13, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29462837/reduced-arterial-vasodilatation-in-response-to-hypoxia-impairs-cerebral-and-peripheral-oxygen-delivery-in-hypertensive-men
#4
Igor A Fernandes, Marcos P Rocha, Monique O Campos, João D Mattos, Daniel E Mansur, Helena N M Rocha, Paulo A C Terra, Vinícius P Garcia, Natália G Rocha, Niels H Secher, Antonio C L Nóbrega
KEY POINTS: Hypoxaemia evokes a repertoire of homeostatic adjustments that maintain oxygen supply to organs and tissues including the brain and skeletal muscles. Because hypertensive patients have impaired endothelial-dependent vasodilatation and an increased sympathetic response to arterial oxygen desaturation, we investigated whether hypertension impairs isocapnic hypoxia-induced cerebral and skeletal muscle hyperaemia to an extent that limits oxygen supply. In middle-aged hypertensive men, vertebral and femoral artery blood flow do not increase in response to isocapnic hypoxia, limiting brain and peripheral hyperaemia and oxygen supply...
February 20, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29275345/preoxygenation-with-non-invasive-ventilation-versus-high-flow-nasal-cannula-oxygen-therapy-for-intubation-of-patients-with-acute-hypoxaemic-respiratory-failure-in-icu-the-prospective-randomised-controlled-florali-2-study-protocol
#5
Jean-Pierre Frat, Jean-Damien Ricard, Rémi Coudroy, René Robert, Stéphanie Ragot, Arnaud W Thille
INTRODUCTION: Endotracheal intubation in intensive care unit (ICU) is a procedure at high risk of life-threatening complications. Among them, severe oxygen desaturation, usually defined as a drop of pulse oxymetry (SpO2 ) below 80%, is the most common. Preoxygenation enables delaying oxygen desaturation occurring during apnea induced by anaesthetic drugs. Data suggest that non-invasive ventilation (NIV) or high-flow nasal cannula (HFNC) oxygen therapy could further increase PaO2 before intubation procedure and prevent oxygen desaturation episodes as compared with standard oxygen...
December 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29273183/-diagnosis-of-lower-limb-peripheral-artery-disease
#6
REVIEW
Guillaume Mahé, Vincent Jaquinandi
Lower limb peripheral artery disease is highly prevalent worldwide and in France. Three different stages can be found: asymptomatic stage, exercise ischemia stage, rest ischemia stage. This review based on current recommendations presents how to diagnose the different stages (Ankle brachial index, Toe-brachial index, oxymetry at rest and exercise oxymetry) in order to manage these patients.
January 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29209787/-different-levels-of-experience-with-anesthetic-agents-of-german-emergency-physicians-results-of-an-online-survey
#7
A Luckscheiter, M Fischer, W Zink
BACKGROUND AND OBJECTIVE: In 2015 practice management guidelines on prehospital emergency anesthesia in adults were published in Germany. The aim of the present study was to evaluate whether emergency physicians follow these guidelines in daily practice and to assess their level of experience with the use of anesthetic agents. MATERIAL AND METHODS: In an online survey the way of induction of preclinical anesthesia (including preoxygenation time and applied monitoring techniques) was assessed with the help of virtual scenarios based on the guidelines...
January 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29054915/prevalence-of-sleep-apnoea-and-capnographic-detection-of-nocturnal-hypoventilation-in-amyotrophic-lateral-sclerosis
#8
Matthias Boentert, Christian Glatz, Cornelia Helmle, Angelika Okegwo, Peter Young
OBJECTIVE: This retrospective study aimed to investigate whether overnight oxymetry and early morning blood gas analysis predict nocturnal hypoventilation (NH) as reflected by night-time hypercapnia in patients with amyotrophic lateral sclerosis (ALS). In addition, prevalence and clinical determinants of sleep apnoea in ALS were evaluated. METHODS: In 250 patients with non-ventilated ALS, transcutaneous capnometry was performed along with polysomnography or polygraphy and early morning blood gases...
October 20, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28539703/triarylmethyl-radicals-epr-study-of-13-c-hyperfine-coupling-constants
#9
Andrey A Kuzhelev, Victor M Tormyshev, Olga Yu Rogozhnikova, Dmitry V Trukhin, Tatiana I Troitskaya, Rodion K Strizhakov, Olesya A Krumkacheva, Matvey V Fedin, Elena G Bagryanskaya
Triarylmethyl (TAM) radicals are widely used in Electron Paramagnetic Resonance (EPR) spectroscopy as spin labels and in EPR imaging as spin probes for in vivo oxymetry. One of the key advantages of TAMs is extremely narrow EPR line, especially in case of deuterated analogues (~5 μT). Another advantage is their slow spin relaxation even at physiological temperatures allowing, in particular, application of pulsed dipolar EPR methods for distance measurements in biomolecules. In this paper a large series of TAM radicals and their deuterated analogues is synthesized, and corresponding spectroscopic parameters including (13)C hyperfine constants are obtained for the first time...
April 2017: Zeitschrift Für Physikalische Chemie
https://www.readbyqxmd.com/read/28456637/a-fast-method-for-high-resolution-oxymetry-study-of-skeletal-muscle-mitochondrial-respiratory-chain-complexes
#10
Jean-Claude Vienne, Catherine Cimetta, Marie Dubois, Thibault Duburcq, Raphaël Favory, Anne-Frédérique Dessein, Monique Fontaine, Marie Joncquel-Chevalier Curt, Jean-Marie Cuisset, Claire Douillard, Karine Mention-Mulliez, Dries Dobbelaere, Joseph Vamecq
High resolution oxymetry study (HROS) of skeletal muscle usually requires 90-120 min preparative phase (dissection, permeabilization and washing). This work reports on the suitability of a rapid muscle preparation which by-passes this long preparation. For a few seconds only, muscle biopsy from pigs is submitted to gentle homogenization at 8000 rotations per minute using an ultra-dispersor apparatus. Subsequent HROS is performed using FCCP instead of ADP, compounds crossing and not plasma membrane, respectively...
July 1, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28301889/geburtshilfe-an%C3%A3-sthesie-bei-exit-prozedur
#11
REVIEW
Alexander Torossian
The ex utero intrapartum treatment (EXIT) procedure is performed as a part of an extended caesarean section for example to treat fetal airway disorders. For treatment, optimal uterine relaxation is necessary, however utero-placental supply of the fetus has to be guaranteed as well. "Balanced" anesthesia, tocolysis and tight maternal arterial blood pressure control are recommended. Standard fetal monitoring comprises pulse oxymetry and echocardiography. The article describes the physiology and anesthestic goals of the EXIT procedure, discusses alternative anesthesia techniques and gives an outlook on emerging progress...
March 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/27909500/cardiac-rhythm-device-threshold-testing-via-pulse-oxymetry
#12
Vladimir Fridman, Cesare Saponieri, Nabil El Sherif, Gioia Turitto
Threshold testing of cardiac rhythm devices is essential to monitoring the proper functioning of such devices (1). However, the currently method of applying multiple ECG leads to the patient is burdensome and time consuming (2). We are presenting a completely new way to perform cardiac rhythm device threshold testing using pulse oximetry. Twenty patients, with varying cardiac rhythm devices and pacing modes, were enrolled and had their atrial and ventricular thresholds tested. A comparison was made between simultaneous threshold determinations via the standard EGM based method and the new pulse oximetry based method...
April 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27904601/evaluation-effects-of-nebulized-gentamicin-in-exacerbation-of-chronic-obstructive-lung-disease
#13
Forogh Soltaninejad, Soleiman Kheiri, Roya Habibian, Arshia Amra, Shahin Asgari-Savadjani
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and mortality throughout the world. Exacerbation of COPD has negative effect on quality of life. Therapeutic effect of nebulized antibiotics in pulmonary infections has been reported previously. Hence, we evaluated the effect of nebulized gentamicin in acute exacerbation of COPD (AECOPD). MATERIALS AND METHODS: In this clinical trial study, 86 hospitalized patients with AECOPD were divided into two groups for using nebulized gentamicin twice daily (case group) and placebo (control group) for 5 days in addition to standard treatment...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27728245/study-of-role-of-pulse-oxymetry-during-nonsedated-upper-gastrointestinal-gi-endoscopic-procedure
#14
S Dasgupta, A L Kakrani, A A Bamanikar, Bhumika Vaishnav
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27679799/prognostic-value-of-initial-assessment-of-residual-hypoventilation-using-nocturnal-capnography-in-mechanically-ventilated-neuromuscular-patients-a-5-year-follow-up-study
#15
Adam Ogna, Julie Nardi, Helene Prigent, Maria-Antonia Quera Salva, Cendrine Chaffaut, Laure Lamothe, Sylvie Chevret, Djillali Annane, David Orlikowski, Frederic Lofaso
BACKGROUND: Restrictive respiratory failure is a major cause of morbidity and mortality in neuromuscular diseases (NMD). Home mechanical ventilation (HMV) is used to treat hypoventilation, and its efficiency is mostly assessed by daytime blood gases or nocturnal oxygen saturation monitoring (SpO2). Non-invasive transcutaneous measure of CO2 (TcCO2) allows to directly assess nocturnal hypercapnia and to detect residual hypoventilation with a higher sensitivity than SpO2. We aimed to compare the prognostic value of nocturnal SpO2 and TcCO2 in ventilated adult NMD patients...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27531200/new-porcine-test-model-reveals-remarkable-differences-between-algorithms-for-spectrophotometrical-haemoglobin-saturation-measurements-with-vls
#16
COMPARATIVE STUDY
John Gade, Gorm Greisen
UNLABELLED: The study created an 'ex vivo' model to test different algorithms for measurements of mucosal haemoglobin saturation with visible light spectrophotometry (VLS). The model allowed comparison between algorithms, but it also allowed comparison with co-oximetry using a 'gold standard' method. This has not been described before. Seven pigs were used. They were perfused with cold Haemaxel, and thus killed, chilled and becoming bloodless. The bronchial artery was perfused with cold blood with known saturation and spectrophotometrical measurements were made through a bronchoscope...
September 2016: Physiological Measurement
https://www.readbyqxmd.com/read/27310989/application-of-co2-waveform-in-the-alveolar-recruitment-maneuvers-of-hypoxemic-patients-during-one-lung-ventilation
#17
RANDOMIZED CONTROLLED TRIAL
Chunshan Dong, Junma Yu, Qi Liu, Chao Wu, Yao Lu
Deterioration of gas exchange during one-lung ventilation (OLV) is caused by both total collapse of the nondependent lung and partial collapse of the dependent lung. Alveolar recruitment maneuver improves lung function during general anesthesia. The objective of this study was to investigate whether there is an indirect relationship between the changes of CO2 expirogram and the selective lung recruitment. To further improve the oxygenation and gas exchange, we compare adjust setting of ventilated parameters based on CO2 expirogram and a preset setting of ventilated parameters during OLV in patients undergoing right-side thoracic surgery...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26903768/formulation-preclinical-and-clinical-evaluation-of-a-new-submicronic-arginine-respiratory-fluid-for-treatment-of-chronic-obstructive-pulmonary-disorder
#18
Virendra Pratap Singh Rathor, Pradeep Chugh, Rashid Ali, Anuj Bhatnagar, Syed Ehtaishamul Haque, Aseem Bhatnagar, Gaurav Mittal
Inhalational drugs often suffer from low pulmonary deposition due to their micronized size. Aim of present study was development and evaluation of a novel submicronic L-arginine respiratory fluid formulation for treatment of cardiopulmonary complications associated with chronic obstructive pulmonary disorder (COPD). Objectives were (a) to develop and characterize submicronic L-arginine respiratory fluid formulation, (b) pre-clinical safety/toxicity study in 2-animal species, (c) in vitro and in vivo evaluation in terms of respiratory fraction, and (d) clinical study to assess safety/efficacy in healthy volunteers/COPD patients...
January 2016: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/26782206/comparison-of-cerebral-oxygen-saturation-and-cerebral-perfusion-computed-tomography-in-cerebral-blood-flow-in-patients-with-brain-injury
#19
COMPARATIVE STUDY
Alexey O Trofimov, George Kalentiev, Oleg Voennov, Vera Grigoryeva
The purpose of this study was to determine the relationship between cerebral tissue oxygen saturation and cerebral blood volume in patients with traumatic brain injury. Perfusion computed tomography of the brain was performed in 25 patients with traumatic brain injury together with simultaneous SctO2 level measurement using cerebral near-infrared oxymetry. The mean age of the injured persons was 34.5±15.6 years (range 15-65); 14 men, 11 women. The Injury Severity Score (ISS) values were 44.4±9.7 (range 25-81)...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/26477263/in-vivo-po2-imaging-of-tumors-oxymetry-with-very-low-frequency-electron-paramagnetic-resonance
#20
REVIEW
Boris Epel, Howard J Halpern
For over a century, it has been known that tumor hypoxia, regions of a tumor with low levels of oxygenation, are important contributors to tumor resistance to radiation therapy and failure of radiation treatment of cancer. Recently, using novel pulse electron paramagnetic resonance (EPR) oxygen imaging, near absolute images of the partial pressure of oxygen (pO2) in tumors of living animals have been obtained. We discuss here the means by which EPR signals can be obtained in living tissues and tumors. We review development of EPR methods to image the pO2 in tumors and the potential for the pO2 image acquisition in human subjects...
2015: Methods in Enzymology
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