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Ting Chen

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https://www.readbyqxmd.com/read/29793095/sex-hormones-affect-acute-and-chronic-stress-responses-in-sexually-dimorphic-patterns-consequences-for-depression-models
#1
Lei Guo, Yi-Xi Chen, Yu-Ting Hu, Xue-Yan Wu, Yang He, Juan-Li Wu, Man-Li Huang, Matthew Mason, Ai-Min Bao
BACKGROUND: Alterations in peripheral sex hormones may play an important role in sex differences in terms of stress responses and mood disorders. It is not yet known whether and how stress-related brain systems and brain sex steroid levels fluctuate in relation to changes in peripheral sex hormone levels, or whether the different sexes show different patterns. We aimed to investigate systematically, in male and female rats, the effect of decreased circulating sex hormone levels following gonadectomy on acute and chronic stress responses, manifested as changes in plasma and hypothalamic sex steroids and hypothalamic stress-related molecules...
May 21, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29792893/tox-expression-decreases-with-progression-of-colorectal-cancers-and-is-associated-with-cd4-t-cell-density-and-fusobacterium-nucleatum-infection
#2
Ting Chen, Qing Li, Xiaoyan Zhang, Ran Long, Yaxin Wu, Jiao Wu, Xiangsheng Fu
Fusobacterium nucleatum (F. nucleatum) in the tumor microenvironment plays an important role in the development of colorectal cancer (CRC). The underlying mechanism of action, however, remains to be elucidated. We evaluated the relation of F. nucleatum amount to thymocyte selection-associated high-mobility group box (TOX) protein expression and CD4+ T cell density in 138 human colorectal tissues. TOX expression and CD4+ T cell density in F. nucleatum negative tissues were significantly higher compared to those in F...
May 21, 2018: Human Pathology
https://www.readbyqxmd.com/read/29792848/subthalamic-nucleus-deep-brain-stimulation-protects-neurons-by-activating-autophagy-via-pp2a-inactivation-in-a-rat-model-of-parkinson-s-disease
#3
Ting-Ting Du, Ying-Chuan Chen, Yong-Quan Lu, Fan-Gang Meng, Hui Yang, Jian-Guo Zhang
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective therapeutic strategy for alleviating disability in patients with moderate to severe Parkinson's disease (PD). Preclinical studies have shown that stimulation of the rat STN can protect against nigral dopaminergic neuron loss. However, the underlying mechanism is unclear. To investigate the molecular basis of the neuroprotective effects of STN stimulation, a rat model of PD was established by unilaterally injecting 6-hydroxydopamine (6-OHDA) into the striatum...
May 21, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29792847/the-polymorphisms-of-atoh-7-et-1-and-ace-in-non-arteritic-anterior-ischemic-optic-neuropathy
#4
Ting Chen, Jin Ma, Guangliang Shan, Yong Zhong
Non-arteritic anterior ischemic optic neuropathy (NAION) is a common cause of acute optic neuropathy in the elderly. The role of the genetic polymorphisms of Atonal Homolog 7 (ATOH7), Endothelin-1 (ET-1) and Angiotensin Converting Enzyme (ACE) in NAION and the combined effects of the gene-gene and gene-medical comorbidities on NAION were not clear. We conducted a perspective, case-control study. 71 NAION patients and 142 age and sex-matched healthy controls were enrolled. Single nucleotide polymorphisms of ATOH7 (rs1900004), ET-1 (rs5370) and ACE (rs1799752) were identified by polymerase chain reaction (PCR) method and all PCR products were screened with Sanger sequencing...
May 21, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29792597/increasing-plant-diversity-with-border-crops-reduces-insecticide-use-and-increases-crop-yield-in-urban-agriculture
#5
Nian-Feng Wan, You-Ming Cai, Yan-Jun Shen, Xiang-Yun Ji, Xiang-Wen Wu, Xiang-Rong Zheng, Wei Cheng, Jun Li, Yao-Pei Jiang, Xin Chen, Jacob Weiner, Jie-Xian Jiang, Ming Nie, Rui-Ting Ju, Tao Yuan, Jian-Jun Tang, Wei-Dong Tian, Hao Zhang, Bo Li
Urban agriculture is making an increasing contribution to food security in large cities around the world. The potential contribution of biodiversity to ecological intensification in urban agricultural systems has not been investigated. We present monitoring data collected from rice fields in 34 community farms in mega-urban Shanghai, China, from 2001 to 2015, and show that the presence of a border crop of soybeans and neighboring crops (maize, eggplant and Chinese cabbage), both without weed control, increased invertebrate predator abundance, decreased the abundance of pests and dependence on insecticides, and increased grain yield and economic profits...
May 24, 2018: ELife
https://www.readbyqxmd.com/read/29792331/predictable-particle-engineering-programming-the-energy-level-carrier-generation-and-conductivity-of-core-shell-particles
#6
Conghui Yuan, Tong Wu, Jie Mao, Ting Chen, Yuntong Li, Min Li, Yiting Xu, Birong Zeng, Weiang Luo, Lingke Yu, Gaofeng Zheng, Lizong Dai
Core-shell structures are of particular interest in the development of advanced composite materials as they can efficiently bring different components together at nanoscale. The advantage of this structure greatly relies on the crucial design of both core and shell, thus achieving an inter-component synergistic effect. In this report, we show that decorating semiconductor nanocrystals with a boronate polymer shell can easily achieve programmable core-shell interactions. Taking ZnO and anatase TiO2 nanocrystals as inner core examples, the effective core-shell interactions can narrow the band gap of semiconductor nanocrystals, change the HOMO and LUMO levels of boronate polymer shell and significantly improve the carrier density of core-shell particles...
May 24, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29791894/highly-tumorigenic-diffuse-large-b-cell-lymphoma-cells-are-produced-by-coculture-with-stromal-cells
#7
Zhiguang Lin, Bobin Chen, Ting Wu, Xiaoping Xu
BACKGROUND/AIMS: Diffuse large B cell lymphoma (DLBCL) is heterogeneous. We aimed to explore how tumor microenvironment promotes lymphoma cell aggressiveness and heterogeneity. METHODS: We created a coculture system using human DLBCL cells and mouse bone marrow stromal cells. Proliferative capacity, drug resistance, clonogenicity, and tumorigenicity were compared in lymphoma cells from the coculture system and lymphoma cells cultured alone. Expression of Notch signaling associated genes was evaluated using real-time reverse transcriptase PCR and Western blot...
May 23, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29791857/a-cytoplasmic-argonaute-protein-promotes-the-inheritance-of-rnai
#8
Fei Xu, Xuezhu Feng, Xiangyang Chen, Chenchun Weng, Qi Yan, Ting Xu, Minjie Hong, Shouhong Guang
RNAi-elicited gene silencing is heritable and can persist for multiple generations after its initial induction in C. elegans. However, the mechanism by which parental-acquired trait-specific information from RNAi is inherited by the progenies is not fully understood. Here, we identified a cytoplasmic Argonaute protein, WAGO-4, necessary for the inheritance of RNAi. WAGO-4 exhibits asymmetrical translocation to the germline during early embryogenesis, accumulates at the perinuclear foci in the germline, and is required for the inheritance of exogenous RNAi targeting both germline- and soma-expressed genes...
May 22, 2018: Cell Reports
https://www.readbyqxmd.com/read/29790969/microcatheter-first-pass-effect-predicts-acute-intracranial-artery-atherosclerotic-disease-related-occlusion
#9
Ting-Yu Yi, Wen-Huo Chen, Yan-Min Wu, Mei-Fang Zhang, A-Lai Zhan, Yue-Hong Chen, Zong-Zhong Wu, Yan-Chuan Shi, Bai-Ling Chen
BACKGROUND: The differentiation between intracranial atherosclerotic stenosis (ICAS) and intracranial embolism as the immediate cause of acute ischemic stroke requiring endovascular therapy is important but challenging. In cases of ICAS, we often observe a phenomenon we call the microcatheter "first-pass effect," which is temporary blood flow through the occluded intracranial artery when the angiographic microcatheter is initially advanced through the site of total occlusion and immediately retrieved proximally...
May 22, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29790675/loss-of-cyclin-dependent-kinase-like-2-predicts-poor-prognosis-in-gastric-cancer-and-its-overexpression-suppresses-cells-growth-and-invasion
#10
Chia-Lang Fang, Yih-Huei Uen, Han-Kun Chen, You-Cheng Hseu, Chih-Chan Lin, Shih-Ting Hung, Ding-Ping Sun, Kai-Yuan Lin
Cyclin-dependent kinase-like 2 (CDKL2), a new member of the cyclin-dependent kinase family, may be involved in gastric cancer (GC) progression. Thus, we conducted this study to explore the clinical effect of CDKL2 in GC. Immunohistochemistry was used to measure CDKL2 levels in gastric tissues. The association of a high CDKL2 level with clinical and pathological characteristics, and the correlation between the CDKL2 level and disease-free and overall survival were analyzed. Transfection was employed to overexpress CDKL2 in GC cells and to investigate the effect of CDKL2 overexpression on cell proliferation and invasion...
May 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29790577/esophageal-igg4-levels-correlate-with-histopathologic-and-transcriptomic-features-in-eosinophilic-esophagitis
#11
Chen E Rosenberg, Melissa K Mingler, Julie M Caldwell, Margaret H Collins, Patricia C Fulkerson, David W Morris, Vincent A Mukkada, Philip E Putnam, Tetsuo Shoda, Ting Wen, Marc E Rothenberg
BACKGROUND: Recent data associate eosinophilic esophagitis (EoE) with IgG4 rather than IgE, but its significance and function have not been determined. Our aims were to measure esophageal IgG4 levels and to determine functional correlations as assessed by histologic and transcriptome analyses. METHODS: This case-control study included pediatric subjects with EoE (≥ 15 eosinophils/HPF) and non-EoE controls. Protein lysates were analyzed for IgA, IgM, and IgG1-IgG4 using the Luminex 100 system; IgE was quantified by ELISA...
May 23, 2018: Allergy
https://www.readbyqxmd.com/read/29790141/-using-trm-to-enhance-the-accuracy-of-ventilator-associated-pneumonia-preventive-measures-implemented-by-neonatal-intensive-care-unit-medical-staffs
#12
Yu-Ting Huang, Chao-Ya Huang, Hsiu-Ya Su, Chen-Te Ma
BACKGROUND & PROBLEMS: Ventilator-associated pneumonia (VAP) is a common healthcare-associated infection in the neonatal intensive care unit (NICU). The average VAP infection density was 4.7‰ in our unit between June and August 2015. The results of a status survey indicated that in-service education lacked specialization, leading to inadequate awareness among staffs regarding the proper care of newborns with VAP and a lack of related care guides. This, in turn, resulted in inconsistencies in care measures for newborns with VAP...
June 2018: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29789780/quantitative-motion-analysis-of-tai-chi-chuan-the-upper-extremity-movement
#13
Tsung-Jung Ho, Kuei-Ting Chou, Cheng-Hsuan Li, Bor-Chen Kuo, Tzung-Chi Huang
The quantitative and reproducible analysis of the standard body movement in Tai Chi Chuan (TCC) was performed in this study. We aimed to provide a reference of the upper extremities for standardizing TCC practice. Microsoft Kinect was used to record the motion during the practice of TCC. The preparation form and eight essential forms of TCC performed by an instructor and 101 practitioners were analyzed in this study. The instructor completed an entire TCC practice cycle and performed the cycle 12 times. An entire cycle of TCC was performed by practitioners and images were recorded for statistics analysis...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29789422/machine-learning-based-radiomics-for-molecular-subtyping-of-gliomas
#14
Chia-Feng Lu, Fei-Ting Hsu, Kevin Li-Chun Hsieh, Yu-Chieh Jill Kao, Sho-Jen Cheng, Justin Bo-Kai Hsu, Ping-Huei Tsai, Ray-Jade Chen, Chao-Ching Huang, Yun Yen, Cheng-Yu Chen
PURPOSE: The new classification announced by the World Health Organization in 2016 recognized five molecular subtypes of diffuse gliomas based on isocitrate dehydrogenase (IDH) and 1p/19q genotypes in addition to histological phenotypes. We aim to determine whether clinical magnetic resonance imaging (MRI) can stratify these molecular subtypes to benefit the diagnosis and monitoring of gliomas. EXPERIMENTAL DESIGN: The data from 456 subjects with gliomas were obtained from The Cancer Imaging Archive...
May 22, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29788092/cytokine-il9-triggers-the-pathogenesis-of-inflammatory-bowel-disease-through-the-mir21-cldn8-pathway
#15
Li Li, Shanshan Huang, Huiling Wang, Kang Chao, Li Ding, Rui Feng, Yun Qiu, Ting Feng, Gaoshi Zhou, Ji-Fan Hu, Minhu Chen, Shenghong Zhang
Background: Cytokine interleukin-9 (IL9) plays an essential role in the pathogenesis of inflammatory bowel disease. However, the molecular mechanism underlying the IL9 pathway remains unknown. Here, we initiate a series of studies to characterize the essential components of this pathway. Methods: The expression of IL9 in colon biopsies from Crohn's disease (CD) and controls were examined by quantitative polymerase chain reaction, immunoblot, and immunohistochemistry...
May 16, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29787979/genome-wide-analysis-reveals-tnfaip8l2-as-an-immune-checkpoint-regulator-of-inflammation-and-metabolism
#16
Ting Li, Wei Wang, Shunyou Gong, Honghong Sun, Huqin Zhang, An-Gang Yang, Youhai H Chen, Xinyuan Li
The interplay between inflammation and metabolism is widely recognized, yet the underlying molecular mechanisms remain poorly characterized. Using experimental database mining and genome-wide gene expression profiling methods, we found that in contrast to other TNFAIP8 family members, TNFAIP8L2 (TIPE2) was preferentially expressed in human myeloid cell types. In addition, Tnfaip8l2 expression drastically decreased in lipopolysaccharide (LPS)-stimulated macrophages. Consequently, Tnfaip8l2 deficiency led to heightened expression of genes that were enriched for leukocyte activation and lipid biosynthesis pathways...
May 19, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29787263/size-resolved-endotoxin-and-oxidative-potential-of-ambient-particles-in-beijing-and-z%C3%A3-rich
#17
Yang Yue, Haoxuan Chen, Ari Setyan, Miriam Elser, Maria Dietrich, Jing Li, Ting Zhang, Xiangyu Zhang, Yunhao Zheng, Jing Wang, Maosheng Yao
PM2.5 pollution has become a global health concern, however its size-resolved health impact remains to be poorly elucidated. Here, ambient particulate matter (PM) were collected into thirteen different size ranges (10 nm-18 μm) and the mass, metal, endotoxin distributions and related oxidative potential were investigated in two regions (Zürich, Switzerland and Beijing, China). Results showed that the two regions had remarkably different PM distribution patterns. Swiss urban samples had a mode around 40 nm with 23...
May 22, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29787232/self-assembled-chiral-gold-supramolecules-with-efficient-laser-absorption-for-enantiospecific-recognition-of-carnitine
#18
Yu-Ting Tseng, Hsiang-Yu Chang, Scott G Harroun, Chien-Wei Wu, Shih-Chun Wei, Zhiqin Yuan, Hung-Lung Chou, Ching-Hsiang Chen, Chih-Ching Huang, Huan-Tsung Chang
Stereospecific recognition of chiral molecules is ubiquitous in chemical and biological systems, thus leading to a strong de-mand for the development of enantiomeric drugs, enantioselective sensors, and asymmetric catalysts. In this study, we demonstrate the ratio of D-Cys and L-Cys playing an important role in determining the optical properties and the structures of self-assembled Cys-Au(I) supramolecules prepared through a simple reaction of tetrachloroaurate(III) with chiral cyste-ine (Cys). The irregularly shaped -[D-Cys-Au(I)] n - or -[L-Cys-Au(I)] n - supramolecules with a size larger than 500 nm pos-sessing strong absorption in the near-UV region and chiroptical characteristics were only obtained from the reaction of Au(III) with D-Cys or L-Cys...
May 22, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29786717/comparison-of-hydroxycarboxylato-imidazole-molybdenum-iv-complexes-and-nitrogenase-protein-structures-indirect-evidence-for-the-protonation-of-homocitrato-femo-cofactors
#19
Si-Yuan Wang, Wan-Ting Jin, Hong-Bin Chen, Zhao-Hui Zhou
Glycolato and R,S-lactato imidazole molybdenum(iv) complexes [Mo3SO3(glyc)2(im)5]·im·H2O (1), Na2[Mo3SO3(R,S-lact)3(im)3]·10H2O (2), and [Mo6O10(R,S-lact)2(im)10]·16H2O (3) have been isolated and characterized (H2glyc = glycolic acid, H2lact = lactic acid, im = imidazole). α-Alkoxy coordination with molybdenum [Mo-Oα-alkoxy 1.993(7)av Å] in 1 and 2 showed obvious differences to their counterpart with α-hydroxy coordination [MoIV3S4(PPh3)3(Hlact)2(lact)] [2.204(4)av Å] as shown in M. N. Sokolov, S. A...
May 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29786440/surface-ligand-promotion-of-carbon-dioxide-reduction-through-stabilizing-chemisorbed-reactive-intermediates
#20
Zhijiang Wang, Lina Wu, Kun Sun, Ting Chen, Zhaohua Jiang, Tao Cheng, William A Goddard
We have explored functionalizing metal catalysts with surface ligands as an approach to facilitate electrochemical carbon dioxide reduction reaction (CO2 RR). To provide a molecular level understanding of the mechanism by which this enhancement occurs, we combine in situ spectroscopy analysis with an interpretation based on quantum mechanics (QM) calculations. We find that a surface ligand can play a critical role in stabilizing the chemisorbed CO2 , which facilitates CO2 activation and leads to a 0.3 V decrease in the overpotential for carbon monoxide (CO) formation...
May 23, 2018: Journal of Physical Chemistry Letters
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