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Ting Chen

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https://www.readbyqxmd.com/read/29169118/characterization-of-a-microbial-polysaccharide-based-bioflocculant-and-its-anti-inflammatory-and-pro-coagulant-activity
#1
Chunying Zhong, Gang Cao, Kuan Rong, Zhengwu Xia, Ting Peng, Honggao Chen, Jiangang Zhou
We describe a novel bioflocculant, MBF-15, which is an exopolysaccharide extracted from the alkaliphilic bacterium Paenibacillus jamilae. The biophysical characteristics of MBF-15 were determined using Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. MBF-15 was also evaluated for its biocompatibility by examining its inflammatory, coagulant, and hemostatic properties in vitro and in vivo. Pretreatment of peripheral blood mononuclear cells with MBF-15 inhibited lipopolysaccharide-stimulated expression of inducible nitric oxide synthase, production of nitric oxide, and secretion of pro-inflammatory cytokines, including tumor necrosis factor-α and interleukin-6...
November 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29168585/the-prognostic-impact-of-serum-bilirubin-in-stage-iv-colorectal-cancer-patients
#2
Lin Yang, Lu-Yao Ge, Ting Yu, Yan Liang, Ying Yin, Hong Chen
BACKGROUND: Bilirubin played a great role in antioxidation and anticancer and has been considered as a promising prognostic factor of non-liver disease-related death in various cancers. The aim of this study was to assess the prognostic value of pre-treatment serum bilirubin in stage IV CRC patients. METHODS: Serum bilirubin including TBIL, DBIL, and IBI which were tested at pre-treatment were investigated in 154 stage IV CRC patients in Zhongda Hospital, Nanjing, China, from July 2005 to July 2011...
November 23, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29168286/comparative-proteomic-profiling-reveals-a-role-for-cisd2-in-skeletal-muscle-aging
#3
Yi-Long Huang, Zhao-Qing Shen, Chia-Yu Wu, Yuan-Chi Teng, Chen-Chung Liao, Cheng-Heng Kao, Liang-Kung Chen, Chao-Hsiung Lin, Ting-Fen Tsai
Skeletal muscle has emerged as one of the most important tissues involved in regulating systemic metabolism. The gastrocnemius is a powerful skeletal muscle composed of predominantly glycolytic fast-twitch fibers that are preferentially lost among old age. This decrease in gastrocnemius muscle mass is remarkable during aging; however, the underlying molecular mechanism is not fully understood. Strikingly, there is a ~70% decrease in Cisd2 protein, a key regulator of lifespan in mice and the disease gene for Wolfram syndrome 2 in humans, within the gastrocnemius after middle age among mice...
November 23, 2017: Aging Cell
https://www.readbyqxmd.com/read/29167926/angiopoietin-like-protein-8-in-early-pregnancy-improves-the-prediction-of-gestational-diabetes
#4
Yun Huang, Xin Chen, Xiaohong Chen, Yu Feng, Heming Guo, Sicheng Li, Ting Dai, Rong Jiang, Xiaoyan Zhang, Chen Fang, Ji Hu
AIMS/HYPOTHESIS: Screening high-risk individuals for gestational diabetes mellitus (GDM) in early pregnancy conventionally relies on established maternal risk factors; however, the sensitivity and specificity of these factors are not satisfactory. The present study aimed to determine whether the concentration of angiopoietin-like protein 8 (ANGPTL8), either alone or combined with other risk factors in early pregnancy, could be used to predict subsequent GDM. METHODS: From August 2015 to January 2016, 474 women receiving prenatal care at around 12-16 weeks of gestation were recruited into the study...
November 22, 2017: Diabetologia
https://www.readbyqxmd.com/read/29167637/variations-in-static-force-control-and-motor-unit-behavior-with-error-amplification-feedback-in-the-elderly
#5
Yi-Ching Chen, Linda L Lin, Yen-Ting Lin, Chia-Ling Hu, Ing-Shiou Hwang
Error amplification (EA) feedback is a promising approach to advance visuomotor skill. As error detection and visuomotor processing at short time scales decline with age, this study examined whether older adults could benefit from EA feedback that included higher-frequency information to guide a force-tracking task. Fourteen young and 14 older adults performed low-level static isometric force-tracking with visual guidance of typical visual feedback and EA feedback containing augmented high-frequency errors...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29167259/whole-genome-sequencing-of-lactobacillus-salivarius-strains-bcrc-14759-and-bcrc-12574
#6
Shih-Hau Chiu, Chien-Chi Chen, Li-Ting Wang, Lina Huang
Lactobacillus salivarius BCRC 14759 has been identified as a high-exopolysaccharide-producing strain with potential as a probiotic or fermented dairy product. Here, we report the genome sequences of L. salivarius BCRC 14759 and the comparable strain BCRC 12574, isolated from human saliva. The PacBio RSII sequencing platform was used to obtain high-quality assemblies for characterization of this probiotic candidate.
November 22, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29166921/identification-of-epidermal-growth-factor-receptor-positive-glioblastoma-using-lipid-encapsulated-targeted-superparamagnetic-iron-oxide-nanoparticles-in-vitro
#7
Huai-Lu Chen, Fei-Ting Hsu, Yu-Chieh Jill Kao, Hua-Shan Liu, Wan-Zhen Huang, Chia-Feng Lu, Ping-Huei Tsai, Ahmed Atef Ahmed Ali, Gilbert Aaron Lee, Ray-Jade Chen, Cheng-Yu Chen
BACKGROUND: Targeted superparamagnetic iron oxide (SPIO) nanoparticles have emerged as a promising biomarker detection tool for molecular magnetic resonance (MR) image diagnosis. To identify patients who could benefit from Epidermal growth factor receptor (EGFR)-targeted therapies, we introduce lipid-encapsulated SPIO nanoparticles and hypothesized that anti-EGFR antibody cetuximab conjugated of such nanoparticles can be used to identify EGFR-positive glioblastomas in non-invasive T2 MR image assays...
November 22, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29166853/proteomic-insight-into-fruit-set-of-cucumber-cucumis-sativus-l-suggests-the-cues-of-hormone-independent-parthenocarpy
#8
Ji Li, Jian Xu, Qin-Wei Guo, Zhe Wu, Ting Zhang, Kai-Jing Zhang, Chun-Yan Cheng, Pin-Yu Zhu, Qun-Feng Lou, Jin-Feng Chen
BACKGROUND: Parthenocarpy is an excellent agronomic trait that enables crops to set fruit in the absence of pollination and fertilization, and therefore to produce seedless fruit. Although parthenocarpy is widely recognized as a hormone-dependent process, hormone-insensitive parthenocarpy can also be observed in cucumber; however, its mechanism is poorly understood. To improve the global understanding of parthenocarpy and address the hormone-insensitive parthenocarpy shown in cucumber, we conducted a physiological and proteomic analysis of differently developed fruits...
November 22, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29166839/-express-the-synergistic-effect-of-treatment-with-triptolide-and-mk-801-in-the-rat-neuropathic-pain-model
#9
Jian Wang, Yu Qiao, Ri-Sheng Yang, Chun-Kui Zhang, Huang-Hui Wu, Jia-Ji Lin, Ting Zhang, Tao Chen, Yun-Qing Li, Yu-Lian Dong, Jin-Lian Li
No abstract text is available yet for this article.
January 1, 2017: Molecular Pain
https://www.readbyqxmd.com/read/29166610/cisd2-haploinsufficiency-disrupts-calcium-homeostasis-causes-nonalcoholic-fatty-liver-disease-and-promotes-hepatocellular-carcinoma
#10
Zhao-Qing Shen, Yi-Fan Chen, Jim-Ray Chen, Yuh-Shan Jou, Pei-Chun Wu, Cheng-Heng Kao, Chih-Hao Wang, Yi-Long Huang, Chian-Feng Chen, Ting-Shuo Huang, Yu-Chiau Shyu, Shih-Feng Tsai, Lung-Sen Kao, Ting-Fen Tsai
CISD2 is located within the chromosome 4q region frequently deleted in hepatocellular carcinoma (HCC). Mice with Cisd2 heterozygous deficiency develop a phenotype similar to the clinical manifestation of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Cisd2 haploinsufficiency causes a low incidence (20%) of spontaneous HCC and promotes HBV-associated and DEN-induced HCC; conversely, 2-fold overexpression of Cisd2 suppresses HCC in these models. Mechanistically, Cisd2 interacts with Serca2b and mediates its Ca(2+) pump activity via modulation of Serca2b oxidative modification, which regulates ER Ca(2+) uptake and maintains intracellular Ca(2+) homeostasis in the hepatocyte...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29166026/electrospun-thin-walled-cuco2o4-c-nanotubes-as-bifunctional-oxygen-electrocatalysts-for-rechargeable-zn-air-batteries
#11
Xiaojun Wang, Yang Li, Ting Jin, Jing Meng, Lifang Jiao, Min Zhu, Jun Chen
Rational design of optimal bifunctional oxygen electrocatalyst with low cost and high activity is greatly desired for realization of rechargeable Zn-air batteries. Herein, we fabricate mesoporous thin-walled CuCo2O4@C with abundant nitrogen-doped nanotubes via coaxial electrospinning technique. Benefiting from high catalytic activity of ultrasmall CuCo2O4 particles, double active specific surface area of mesoporous nanotubes, and strong coupling with N-doped carbon matrix, the obtained CuCo2O4@C exhibits outstanding oxygen electrocatalytic activity and stability, which in terms of a positive onset potential (0...
November 22, 2017: Nano Letters
https://www.readbyqxmd.com/read/29165996/itop-q-an-intelligent-tool-for-top-down-proteomics-quantitation-us-ing-dyamond-algorithm
#12
Hui-Yin Chang, Ching-Tai Chen, Chu-Ling Ko, Yi-Ju Chen, Yu-Ju Chen, Wen-Lian Hsu, Chiun-Gung Juo, Ting-Yi Sung
Top-down proteomics using liquid chromatogram coupled with mass spectrometry has been increasingly applied for analyzing intact proteins to study genetic variation, alternative splicing, and post-translational modifications (PTMs) of the proteins (proteoforms). However, only a few tools have been developed for charge state deconvolution, monoisotopic/average molecular weight determination and quantitation of proteoforms from LC-MS1 spectra. Though Decon2LS and MASH Suite Pro have been available to provide intra-spectrum charge state deconvolution and quantitation, manual processing is still required to quantify proteoforms across multiple MS1 spectra...
November 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29164767/the-association-between-steatosis-and-diabetes-with-hepatocellular-carcinoma-in-non-genotype-3-chronic-hepatitis-c-patients
#13
Yi-Hao Yen, Ming-Tsung Lin, Fang-Ying Kuo, Kuo-Chin Chang, Ming-Chao Tsai, Po-Lin Tseng, Cheng-Kun Wu, Jung-Ting Lin, Tsung-Hui Hu, Sheng-Nan Lu, Jing-Houng Wang, Chao-Hung Hung, Chien-Hung Chen
BACKGROUND AND AIMS: Diabetes mellitus (DM) has been found to be strongly associated with an increased risk of hepatocellular carcinoma (HCC) among chronic hepatitis C (CHC) patients. Several studies have also found an association between metabolic steatosis and the risk of HCC in CHC patients, whether this latter association has been accounted for by the known relationship between DM and HCC is still unknown. METHODS: A cohort consisting of 976 non-genotype 3 patients histologically proven to have CHC and treated with interferon and ribavirin was studied...
November 22, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29164543/-exploration-of-recent-mobile-technologies-applied-in-nursing-education
#14
Ting-Ting Wu, Yi-Chen Lu, Lei Chang
The development of science and technology has fundamentally changed people's lives and the way that medical systems function. Increasingly, mobile technologies are being introduced and integrated into classroom teaching and clinical applications, resulting in healthcare providers introducing innovative applications into health education. These applications enhance the clinical, education, and research expertise of medical staffs and nurses, while improving quality of care and providing new experiences for patients...
December 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29163911/hyperfine-adjustment-of-flexible-pore-surface-pockets-enables-smart-recognition-of-gas-size-and-quadrupole-moment
#15
Chun-Ting He, Zi-Ming Ye, Yan-Tong Xu, Dong-Dong Zhou, Hao-Long Zhou, Da Chen, Jie-Peng Zhang, Xiao-Ming Chen
The pore size and framework flexibility of hosts are of vital importance for molecular recognition and related applications, but accurate control of these parameters is very challenging. We use the slight difference of metal ion size to achieve continuous hundredth-nanometer pore-size adjustments and drastic flexibility modulations in an ultramicroporous metal-organic framework, giving controllable N2 adsorption isotherm steps, unprecedented/reversed loading-dependence of H2 adsorption enthalpy, quadrupole-moment sieving of C2H2/CO2, and an exceptionally high working capacity for C2H2 storage under practical conditions (98 times that of an empty cylinder)...
November 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29163776/mir-1268b-confers-chemosensitivity-in-breast-cancer-by-targeting-erbb2-mediated-pi3k-akt-pathway
#16
Wen-Jie Zhu, Xu Chen, Ya-Wen Wang, Hai-Ting Liu, Ran-Ran Ma, Peng Gao
Chemoresistance represents a major obstacle to effective therapy for breast cancer. Emerging evidences associated aberrantly expressed miRNAs with tumor development and chemoresistance. MiR-1268b has never been studied in any cancers before, and its roles in mediating tumor progression and drug resistance are still unclear. Selected from miRNA microarray and confirmed by real-time quantitative PCR (RT-qPCR), miR-1268b was found to be significantly upregulated in drug sensitive and ERBB2 negative tissues, as well as in breast cancer patients with low clinical stage...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163769/yap1-is-essential-for-tumor-growth-and-is-a-potential-therapeutic-target-for-egfr-dependent-lung-adenocarcinomas
#17
Ting-Fang Lee, Yu-Chi Tseng, Wei-Chin Chang, Yi-Chen Chen, Yu-Rung Kao, Teh-Ying Chou, Chao-Chi Ho, Cheng-Wen Wu
Epidermal growth factor receptor (EGFR) mutations are found in lung adenocarcinomas leading to tumor cells proliferation and survival. EGFR tyrosine kinase inhibitors (TKIs) that block EGFR activity are effective therapeutics for EGFR-mutant lung adenocarcinoma patients, but TKI-resistance inevitably occurs. The YES-associated protein (YAP1) transcription coactivator has been implicated as an oncogene and is amplified in human cancers and provides tumor cells strong proliferation and survival cues. This study investigated the roles of YAP1 in lung adenocarcinoma by exploring its regulation and functions mediated by EGFR signaling...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163701/high-levels-of-depdc1b-predict-shorter-biochemical-recurrence-free-survival-of-patients-with-prostate-cancer
#18
Shoumin Bai, Ting Chen, Tao Du, Xianju Chen, Yiming Lai, Xiaoming Ma, Wanhua Wu, Chunhao Lin, Leyuan Liu, Hai Huang
DEP domain-containing protein 1B (DEPDC1B) has been reported to serve important functions in breast cancer and non-small cell lung cancer. However, its involvement in the development of prostate cancer (PCa) remains unclear. Therefore, the present study aimed to investigate the expression and clinical significance of DEPDC1B in tumor tissues from patients diagnosed with PCa. A total of 80 prostate tissue samples were collected following prostatectomy to generate a tissue microarray for immunohistochemical analysis of DEPDC1B protein expression...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29163602/effects-of-ridge-furrow-system-combined-with-different-degradable-mulching-materials-on-soil-water-conservation-and-crop-production-in-semi-humid-areas-of-china
#19
Xiaolong Ren, Xiaoli Chen, Tie Cai, Ting Wei, Yang Wu, Shahzad Ali, Peng Zhang, Zhikuan Jia
In China, the ridge-furrow water conservation planting (RC) system is advantageous for improving crop yields and rainwater use efficiency. In RC planting system, plastic film-mulched ridges are employed for water harvesting while the furrows serve as infiltration and planting belts. To optimize the RC system and to overcome problems due to the lack of water in semi-humid areas at risk of drought, we mulched the furrows with 8% biodegradable film (RCSB), liquid film (RCSL), or no mulching in the furrows (RCSN), while conventional flat planting (CF) was employed as the control...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29163454/low-molecular-weight-chitosan-supplementation-increases-the-population-of-prevotella-in-the-cecal-contents-of-weanling-pigs
#20
Ting Yu, Yu Wang, Shicheng Chen, Min Hu, Zhiling Wang, Guozhong Wu, Xianyong Ma, Zhuang Chen, Chuntian Zheng
Low-molecular-weight chitosan (LC) promoted growth in weaned piglets as an alternative to feed-grade antibiotics. To investigate the influence of LC supplementation on piglets' gut microbiome and compare the differences in community composition between LC and antibiotics with ZnO addition, we assessed the cecal microbial community by 16S rRNA gene sequencing with three treatments consisting of basal diet (CTR group), basal diet with low-molecular-weight chitosan (LC group), and basal diet with antibiotic and ZnO (AZ group)...
2017: Frontiers in Microbiology
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