Peter Zhukovsky, Maria Ironside, Jessica M Duda, Amelia D Moser, Kaylee E Null, Maeva Dhaynaut, Marc Normandin, Nicolas J Guehl, Georges El Fakhri, Madeline Alexander, Laura M Holsen, Madhusmita Misra, Rajesh Narendran, Jocelyn Hoye, Evan Morris, Shiba M Esfand, Jill M Goldstein, Diego A Pizzagalli
BACKGROUND: Understanding the neurobiological effects of stress is critical for addressing the etiology of major depressive disorder (MDD). Using a dimensional approach involving individuals with differing degree of MDD risk, we investigated (1) the effects of acute stress on cortico-cortical and subcortical-cortical functional connectivity (FC), and (2) how such effects related to gene expression and receptor maps. METHODS: Across 115 participants (37 controls, 39 remitted MDD, 39 current MDD), we evaluated the effects of stress on FC during the Montreal Imaging Stress Task...
February 21, 2024: Biological Psychiatry