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https://www.readbyqxmd.com/read/29667742/genetic-association-and-expression-analyses-of-the-phosphatidylinositol-4-phosphate-5-kinase-pip5k1c-gene-in-alcohol-use-disorder-relevance-for-pain-signaling-and-alcohol-use
#1
Ji Soo Lee, Jill L Sorcher, Allison D Rosen, Ruslan Damadzic, Hui Sun, Melanie Schwandt, Markus Heilig, John Kelly, Kelsey L Mauro, Audrey Luo, Daniel Rosoff, Christine Muench, Jeesun Jung, Zachary A Kaminsky, Falk W Lohoff
BACKGROUND: The gene encoding Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) has been recently implicated in pain regulation. Interestingly, a recent cross-tissue and cross-phenotypic epigenetic analysis identified the same gene in alcohol use disorder (AUD). Given the high comorbidity between AUD and chronic pain, we hypothesized that genetic variation in PIP5K1C might contribute to susceptibility to AUD. METHODS: We conducted a case-control association study of genetic variants in PIP5K1C...
April 18, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29649967/influence-of-maternal-and-own-genotype-at-tanning-dependence-related-snps-on-sun-exposure-in-childhood
#2
Jasmine Khouja, Sarah J Lewis, Carolina Bonilla
BACKGROUND: Research suggests there may be a genetic influence on the likelihood of becoming tanning dependent (TD). The way in which mothers regulate their children's sun exposure may be affected by being TD. We investigated the associations between single nucleotide polymorphisms (SNPs) related to being TD and early sun exposure. METHODS: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used. Associations between 17 TD related SNPs in children and their mothers and 10 sun exposure variables in children (assessed via questionnaire at age 8) were analyzed in logistic and ordinal logistic regressions...
April 12, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29624642/cannabidiol-regulates-behavioural-alterations-and-gene-expression-changes-induced-by-spontaneous-cannabinoid-withdrawal
#3
Francisco Navarrete, Auxiliadora Aracil-Fernández, Jorge Manzanares
BACKGROUND AND PURPOSE: Cannabidiol (CBD) represents a promising therapeutic tool for treating cannabis use disorder (CUD). This study aimed to evaluate the effects of CBD on the behavioural and gene expression alterations induced by spontaneous cannabinoid withdrawal. EXPERIMENTAL APPROACH: Spontaneous cannabinoid withdrawal was evaluated 12 h after cessation of CP-55,940 treatment (0.5 mg·kg-1 /12 h; intraperitoneally (i.p.); 7 days) in C57BL/6J mice. The effects of CBD (5, 10 and 20 mg·kg-1 ; i...
April 6, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29620694/genetic-polymorphisms-associated-with-constipation-and-anticholinergic-symptoms-in-patients-receiving-clozapine
#4
Anssi Solismaa, Olli Kampman, Leo-Pekka Lyytikäinen, Niko Seppälä, Merja Viikki, Nina Mononen, Terho Lehtimäki, Esa Leinonen
BACKGROUND: Clozapine impairs gastrointestinal motility owing to its anticholinergic and antiserotonergic properties. This commonly leads to constipation and potentially to more severe complications such as bowel obstruction and ischemia. The aim of this study was to determine whether genetic variations in the genes encoding muscarinic and serotonergic receptors (CHRM2, CHRM3, HTR2, HTR3, HTR4, and HTR7) explain the variations in incidence of constipation and anticholinergic symptoms during clozapine treatment...
April 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29601950/association-between-mdr-1-cyp3a4-oprm-1-gene-polymorphisms-and-the-post-caesarean-fentanyl-analgesic-effect-on-chinese-women
#5
Jingliang Zhang, Li Zhang, Xia Zhao, Sheliang Shen, Xiaopan Luo, Yunlong Zhang
OBJECTIVE: Our study aimed to evaluate the association between the multidrug resistance 1 (MDR1 )/cytochrome P450 3A4 (CYP3A4)/μ-opioid receptor (OPRM1 ) gene polymorphisms and the post-caesarean analgesic effect of fentanyl on Chinese women. METHODS: We recruited 240 patients who received lower segment caesarean section surgeries. Sanger sequencing was used to analyze the MDR1 1236C > T/CYP3A4*1G/OPRM1 A118G polymorphisms. We evaluated post-operative fentanyl consumption and the effect of intravenous analgesia in patients with different genotypes...
March 27, 2018: Gene
https://www.readbyqxmd.com/read/29579315/co-expression-of-%C3%AE-and-%C3%A2-opioid-receptors-by-mouse-colonic-nociceptors
#6
Raquel Guerrero-Alba, Eduardo Emmanuel Valdez-Morales, Nestor Nivardo Jiménez-Vargas, Romke Bron, Daniel Poole, David Reed, Joel Castro, Melissa Campaniello, Patrick A Hughes, Stuart M Brierley, Nigel Bunnett, Alan E Lomax, Stephen Vanner
BACKGROUND AND PURPOSE: To better understand opioid signaling in visceral nociceptors, we examined the expression and selective activation of mu (MOR) and delta opioid receptors (DOR) by dorsal root ganglia (DRG) neurons innervating the mouse colon. EXPERIMENTAL APPROACH: DRG neurons projecting to the colon were identified by retrograde tracing. DOR-GFP reporter mice, in situ hybridization, single-cell RT-PCR, and MOR-specific antibodies were used to characterize expression of MOR and DOR...
March 26, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29577422/notch4-is-a-possible-novel-susceptibility-gene-for-dilated-cardiomyopathy-in-the-chinese-population-a-case-control-study
#7
Xiaoqing Shi, Yang Zhang, Bingjie Li, Mengle Peng, Yingying Yuan, Ximing Wang, Xinqiang Li, Dongze Yu, Yongzhe Li, Dongchun Qin
BACKGROUND: The incidence of dilated cardiomyopathy (DCM) has increased in recent years, and many studies have sought to further improve the general understanding of this condition. Previous studies have demonstrated that some single nucleotide polymorphisms (SNPs) associated with systemic lupus erythematosus also affect susceptibility to DCM, suggesting that immune-related diseases may share similar genetic susceptibility. Recent large-scale and genome-wide association studies have identified NCR3, NOTCH4, CYP1A2, ITGA1, OPRM1, ST8SIA2, and LINC00704 as genetic risk factors associated with cardiac manifestations of neonatal lupus...
March 26, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29577418/methadone-not-a-magic-bullet-in-melanoma-therapy
#8
Marie-Charlotte Brüggen, Joanna Mangana, Anja Irmisch, Lars E French, Mitchell P Levesque, Phil F Cheng, Reinhard Dummer
Methadone (Met) mainly acts as a μ-opioid receptor agonist. Recent evidence pointing towards the role of Met in sensitization of certain cancer cell lines to chemotherapeutic agents has promoted the hypothesis that Met may be a useful adjuvant to cancer chemotherapy. We wanted to address whether Met has, alone or in combination with a chemotherapeutic agent, an effect on melanoma cell viability in vitro. Only a small fraction (4.3%) of our 102 melanoma biobank cell lines with RNA sequencing data showed expression of the main receptor for Met (OPRM1)...
March 25, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29576267/interaction-between-the-opioid-receptor-oprm1-gene-and-mother-child-language-style-matching-prospectively-predicts-children-s-separation-anxiety-disorder-symptoms
#9
Sameen Boparai, Jessica L Borelli, Lindsey Partington, Patricia Smiley, Ella Jarvik, Hannah F Rasmussen, Lauren C Seaman, Erika L Nurmi
Recent research suggests that lower mother-child language style matching (LSM) is associated with greater physiological reactivity and insecure attachment in school-aged children, but to date no studies have explored this measure of parent-child behavioral matching for its association with children's anxiety symptoms, a well-known correlate of attachment insecurity and heightened physiological reactivity. There is also considerable evidence of genetic risk for anxiety, including possession of the OPRM1 minor allele, 118G...
March 22, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29575474/epigenetic-variation-in-oprm1-gene-in-opioid-exposed-mother-infant-dyads
#10
Elisha M Wachman, Marie J Hayes, Hira Shrestha, Fnu Nikita, Angela Nolin, Leonie Hoyo, Katrina Daigle, Hendrée E Jones, David A Nielsen
Neonatal abstinence syndrome (NAS) due to in-utero opioid exposure has significant variability of severity. Preliminary studies have suggested that epigenetic variation within the μ-opioid receptor (OPRM1) gene impacts NAS. We aimed to determine if DNA methylation in OPRM1 within opioid-exposed mother-infant dyads is associated with differences in NAS severity in an independent cohort. Full-term opioid-exposed newborns and their mothers (N=68 pairs) were studied. A DNA sample was obtained and then assessed for level of DNA methylation at 20 CpG sites within the OPRM1 promoter region by next-generation sequencing...
March 25, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29564682/opioid-exposure-is-associated-with-aberrant-dna-methylation-of-oprm1-promoter-region-in-a-chinese-han-population
#11
Jiawei Xu, Teng Wang, Zhiyang Su, Xinyao Zhou, Yuqian Xiang, Lin He, Candong Li, Zhaoyang Yang, Xinzhi Zhao
The μ-opioid receptor (OPRM1) plays an important role in opiate addiction. The OPRM1 gene promoter showed hypermethylation in lymphocytes of opiate addicts as well as opioid medications users, while the methylation status displayed ethnic diversity. The purpose of the study was to investigate the methylation pattern of OPRM1 promoter in the Han Chinese population. We analyzed 22 CpG sites located in OPRM1 promoter in 186 former opiate addicts (94 males and 92 females) and 184 healthy controls (102 males and 82 females)...
March 21, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/29517466/allelic-frequencies-of-60-pharmacogene-variants-assessed-within-a-burmese-population-residing-in-northeast-indiana-usa
#12
Carrie C Hoefer, Emily J Brick, Ann Savariar, David F Kisor, Amy Dawson, Ahmad Khatri, Brian Henriksen
AIM: The aim of this study was to investigate 60 SNPs pertaining to drug metabolism and pharmacodynamics in the Burmese refugee population in the Fort Wayne, Indiana area to better inform patient care. MATERIALS & METHODS: Sixty-two self-identified Burmese refugees were genotyped for 60 common SNPs pertaining to pharmacokinetic and pharmacodynamic pharmacogenes. The resulting allelic frequencies were compared with Ensembl's database for surrounding populations to Myanmar and America...
March 8, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29497192/no-genetic-association-between-a118g-polymorphism-of-%C3%AE-opioid-receptor-gene-and-schizophrenia-and-bipolar-disorders
#13
Shaghayegh Yazdani, Vahid Salimi, Mohammad Reza Eshraghian, Mohammad Shayestehpour, Alireza Pourtalebi-Firoozabadi, Bizhan Romani, Azadeh Shadab, Mohammad Reza Aghasadeghi, Jila Yavarian
Background: Schizophrenia (SZ) and bipolar disorder (BD) are chronic and multifactorial psychiatric disorders that might be affected by different genes in combination with environmental factors. There is evidence of association between polymorphisms of μ-opioid receptor gene (OPRM1) with these disorders. Objectives: The aim of this study was to investigate the genetic association between OPRM1 A118G SNP in SZ and BD patients in comparison with healthy controls (HCs)...
October 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29497164/the-oprm1-a118g-polymorphism-converging-evidence-against-associations-with-alcohol-sensitivity-and-consumption
#14
M E Sloan, T D Klepp, J L Gowin, J E Swan, H Sun, B L Stangl, V A Ramchandani
The endogenous opioid system may be involved in the development and maintenance of alcohol use disorder (AUD) and is a target for existing AUD pharmacotherapies. A functional polymorphism of the mu-opioid receptor gene (OPRM1 A118G, rs1799971) may alter the risk of developing AUD. Human laboratory studies have demonstrated that minor allele carriers self-administer more alcohol, show greater sensitivity to alcohol's effects, and exhibit increased alcohol-induced dopamine release. On the other hand, large genome-wide association studies and meta-analyses of candidate gene studies have not found an association between this genotype and alcohol dependence diagnosis...
February 2, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29474345/opioid-related-genetic-polymorphisms-do-not-influence-postoperative-opioid-requirement-a-prospective-observational-study
#15
Frédéric Aubrun, Noël Zahr, Olivier Langeron, Nicolas Boccheciampe, Nathalie Cozic, Lisa Belin, Jean-Sebastien Hulot, Frederic Khiami, Bruno Riou
BACKGROUND: Among the various factors that may influence the pharmacological response to opioids, genetic polymorphisms [single nucleotide polymorphisms (SNP)] have generated some interest. OBJECTIVES: To examine the influence on morphine dose requirements and adverse events in the postoperative period of four SNP [opioid receptor mu1 (OPRM1), ATP-binding cassette subfamily B, member 1 (ABCB1) ex-21 and ex-26, catechol-o-methyltransferase (COMT)] in candidate genes involved in morphine pharmacodynamics and pharmacokinetics...
February 22, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29473323/adult-spinal-opioid-receptor-%C3%A2%C2%B51-expression-after-incision-is-altered-by-early-life-repetitive-tactile-and-noxious-procedures-in-rats
#16
Nynke J van den Hoogen, Roel Ri van Reij, Jacob Patijn, Dick Tibboel, Elbert Aj Joosten
Clinical and experimental data suggests that noxious stimulation at critical stages of development results in long-term changes on nociceptive processing in later life. Here, we use an established, well-documented rat model of repetitive noxious procedures closely mimicking the clinical situation in the NICU. In order to understand molecular changes underlying the long-term consequences of repetitive stimulation of the developing nociceptive system the present study aims to analyse the presence of the µ-opioid-receptor-1 (OPRM1)...
February 22, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29431852/nicotine-use-smoking-is-associated-with-the-efficacy-of-naltrexone-in-the-treatment-of-alcohol-dependence
#17
Raymond F Anton, Patricia K Latham, Konstantin E Voronin, Patrick K Randall, Sarah W Book, Michaela Hoffman, Joseph P Schacht
BACKGROUND: The opioid antagonist naltrexone is not efficacious for every alcohol treatment seeker. However, various individual factors, such as genetic differences and nicotine-use/smoking status, have been suggested as predictors of naltrexone response. In a randomized clinical trial, we previously reported that nicotine-use/smoking status might be a stronger predictor of naltrexone efficacy than OPRM1 A118G single nucleotide polymorphism (SNP) genotype. In this report, we further characterize the nicotine-users in that trial, examine other drinking outcomes, examine the influence of smoking change on naltrexone effects on drinking, and validate the result in smokers with disialo carbohydrate-deficient transferrin (%dCDT) change as an independent biomarker of response...
February 12, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29422496/opioid-antagonists-and-the-a118g-polymorphism-in-the-%C3%AE-opioid-receptor-gene-effects-of-gsk1521498-and-naltrexone-in-healthy-drinkers-stratified-by-oprm1-genotype
#18
Hisham Ziauddeen, Liam J Nestor, Naresh Subramaniam, Chris Dodds, Pradeep J Nathan, Sam R Miller, Bhopinder K Sarai, Kay Maltby, Disala Fernando, Liling Warren, Louise K Hosking, Dawn Waterworth, Anna Korzeniowska, Beta Win, Duncan B Richards, Lakshmi Vasist Johnson, Paul C Fletcher, Edward T Bullmore
This corrects the article DOI: 10.1038/npp.2016.60.
March 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29413524/mu-opioid-pharmacology-40-years-to-the-promised-land
#19
Gavril W Pasternak
Opioids continue to play a major role in medicine, but not without problems. Side effects limit their utility medically, while the potential of addiction has had a major societal impact. Pharmacologists have been trying to develop opioids lacking side effects since the first derivative, heroin, was synthesized in the 1870s. The identification of opioid receptors about 40 years ago opened up new insights into our understanding of opioid action, fueled by the molecular biology revolution of the 1980s and 1990s...
2018: Advances in Pharmacology
https://www.readbyqxmd.com/read/29391279/gut-microbiota-modulates-alcohol-withdrawal-induced-anxiety-in-mice
#20
Hui-Wen Xiao, Chang Ge, Guo-Xing Feng, Yuan Li, Dan Luo, Jia-Li Dong, Hang Li, Haichao Wang, Ming Cui, Sai-Jun Fan
Excessive alcohol consumption remains a major public health problem that affects millions of people worldwide. Accumulative experimental evidence has suggested an important involvement of gut microbiota in the modulation of host's immunological and neurological functions. However, it is previously unknown whether enteric microbiota is implicated in the formation of alcohol withdrawal-induced anxiety. Using a murine model of chronic alcoholism and withdrawal, we examined the impact of alcohol consumption on the possible alterations of gut microbiota as well as alcohol withdrawal-induced anxiety and behavior changes...
January 29, 2018: Toxicology Letters
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