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https://www.readbyqxmd.com/read/29452703/validation-of-the-eighth-edition-of-the-american-joint-committee-on-cancer-staging-system-for-ampulla-of-vater-cancer
#1
Sung Joo Kim, Soyeon An, Hyo Jeong Kang, Joo Young Kim, Min Ah Jang, Jae Hoon Lee, Ki-Byung Song, Dae Wook Hwang, HyungJun Cho, Song Cheol Kim, Eunsil Yu, Seung-Mo Hong
BACKGROUND: The American Joint Committee on Cancer recently proposed the eighth edition of cancer staging system. Validation studies are required to evaluate the prognostic stratification of ampulla of Vater cancer patients. METHODS: In the study, 369 operatively resected patients with ampullary cancers were grouped based on the eighth T (T1a, limited to sphincter of Oddi; T1b, invasion to duodenal submucosa; T2, invasion to duodenal proper muscle; T3a, invasion to pancreas ≤0...
February 13, 2018: Surgery
https://www.readbyqxmd.com/read/29444223/glp-1-receptor-expression-within-the-human-heart
#2
Laurie L Baggio, Bernardo Yusta, Erin E Mulvihill, Xiemin Cao, Catherine J Streutker, Jagdish Butany, Thomas P Cappola, Kenneth B Margulies, Daniel J Drucker
Glucagon-like peptide-1 receptor (GLP-1R) agonists, used to treat type 2 diabetes and obesity, reduce rates of myocardial infarction and cardiovascular death. The GLP-1R has been localized to the human sinoatrial node; however, its expression in ventricular tissue remains uncertain. Here we studied GLP-1R expression in the human heart using GLP-1R-directed antisera, quantitative PCR, reverse transcription PCR to detect full length mRNA transcripts, and in situ hybridization. GLP1R mRNA transcripts, encompassing the entire open reading frame, were detected in all four cardiac chambers from 15 hearts at levels approximating those detected in human pancreas...
February 12, 2018: Endocrinology
https://www.readbyqxmd.com/read/29435751/impact-of-anatomical-position-of-the-pancreas-on-postoperative-complications-and-drain-amylase-concentrations-after-laparoscopic-distal-gastrectomy-for-gastric-cancer
#3
Koshi Kumagai, Naoki Hiki, Souya Nunobe, Satoshi Kamiya, Masahiro Tsujiura, Satoshi Ida, Manabu Ohashi, Toshiharu Yamaguchi, Takeshi Sano
BACKGROUND: Laparoscopic surgery for gastric cancer requires traction or compression of the pancreas, with the extent depending on the anatomical position of the pancreas. This study investigated the impact of the position of the pancreas on postoperative complications and drain amylase concentrations after laparoscopic distal gastrectomy (LDG). METHODS: Gastric cancer patients who underwent LDG were assessed retrospectively. The following anatomical parameters were measured retrospectively in preoperative computed tomography sagittal projections: the length of the vertical line between the pancreas and the aorta (P-A length), representing the height of the slope looking down the celiac artery from the top of the pancreas, and the angle between a line drawn from the upper border of the pancreas to the root of the celiac artery and the aorta (UP-CA angle), representing the steepness of the slope...
February 12, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29423821/the-emerging-role-of-stereotactic-radiotherapy-in-gastrointestinal-malignancies-a-review-of-the-literature-and-analysis-from-the-irish-perspective
#4
Siobhra O'Sullivan, Daniel N Cagney
Primary and secondary malignancies of the liver and pancreas result in significant morbidity and mortality, with increasing incidence and increasing demands on health services worldwide. Surgery is the only curative single modality of treatment and remains the gold standard. Unfortunately, up to 80% of the patients present with unresectable disease, and so, alternative efficacious local and systemic treatments are needed. Technologic advances in radiotherapy over recent decades have meant that precision high-dose treatment with stereotactic body radiotherapy (SBRT) has emerged as a viable cost-effective outpatient-based treatment in the management of these difficult to treat abdominal malignancies...
February 8, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29423167/a-rare-case-of-massive-lower-gastrointestinal-bleeding-from-a-ruptured-splenic-artery-aneurysm
#5
Ravi Maharaj, Barry Raghunanan, Wayne Mohammed, Rakesh Rambally, Vandana Devika Sookdeo, Dave Harnanan, Wayne A Warner
Splenic artery aneurysms (SAAs) are an extremely rare cause of asymptomatic massive lower gastrointestinal bleeding with less than a handful of patients surviving such a presentation. A 24-year-old female presented in shock after multiple episodes of massive rectal bleeding. Imaging revealed a heterogeneous mass arising from the tail of the pancreas eroding into the splenic flexure of the colon. Further episodes of bleeding led to an exploratory laparotomy. Intraoperatively, a suspected neoplastic process arising from the tail of the pancreas with contiguous involvement of the splenic flexure of the colon and the greater curvature of the stomach was noted...
February 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29421420/continuous-blood-glucose-monitoring-may-detect-carotid-occlusion-intolerance-during-carotid-artery-stenting
#6
Ryo Hiramatsu, Motomasa Furuse, Ryokichi Yagi, Tomohisa Ohmura, Hiroyuki Ohnishi, Naokado Ikeda, Naosuke Nonoguchi, Shinji Kawabata, Shigeru Miyachi, Toshihiko Kuroiwa
BACKGROUND: The frequency of the occurrence of adverse events associated with carotid artery stenting (CAS) is usually low, but serious adverse events such as cerebral hyperperfusion syndrome (CHS) may occur. Real-time monitoring is ideal for the early detection of adverse events during the surgical procedure. This study aimed to evaluate continuous blood glucose (BG) monitoring for the detection of adverse events during CAS. METHODS: Forty patients undergoing scheduled CAS were prospectively enrolled...
February 5, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29414805/a-novel-approach-for-hepatic-arterial-reconstruction-after-total-pancreatectomy-with-common-hepatic-artery-resection-using-inferior-phrenic-artery
#7
Takatsugu Matsumoto, Keiichi Kubota, Taku Aoki, Takayuki Shimizu, Shozo Mori, Masato Kato, Hirotaka Asato
BACKGROUND/AIMS: Because of the anatomical characteristics, pancreatic cancers (PC) can easily invade to visceral vessels such as celiac artery, superior mesenteric artery, common hepatic artery (CHA) and portal vein, which makes curative resection difficult. In this study, we report an R0 resection for locally advanced PC by total pancreatectomy, combined resection of CHA, and reconstruction of hepatic artery using autologous left inferior phrenic artery (IPA). METHODS: A 47-year-old woman with complaints of low back pain was referred to our department...
February 7, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29399525/transplant-artery-thrombosis-and-outcomes
#8
REVIEW
Mark D Sugi, Hassan Albadawi, Grace Knuttinen, Sailendra G Naidu, Amit K Mathur, Adyr A Moss, Rahmi Oklu
Post-transplantation allograft arterial thrombosis is a well-recognized complication associated with solid organ transplantation. Much of the literature is centered on liver and kidney transplantation, which will therefore serve as the principle basis for this review, with a brief discussion on pancreas transplantation and associated arterial complications. The number of solid organ transplants has been steadily increasing over the past decade in parallel with growing demand for organs and expansion of the transplantation criteria for both donors and recipients...
December 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29397891/modified-appleby-procedure-for-locally-advanced-pancreatic-cancer
#9
Shanley Deal, Derek Nathan, Flavio G Rocha
Locally advanced pancreas cancer (LAPC) involving the celiac axis is typically considered unresectable and carries a poor prognosis. We present a case of a patient with LAPC who underwent a modified Appleby procedure for tumor clearance following neoadjuvant therapy. Technical aspects include diagnostic laparoscopy to exclude occult metastatic disease followed by complete mobilization of the pancreas and spleen, preservation of the left gastric artery, and resection and reconstruction of the common hepatic artery...
January 10, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29394853/-gastrectomy-with-intra-aortic-balloon-pumping-support-for-a-hemorrhagic-advanced-gastric-cancer-patient-with-severe-coronary-stenosis
#10
Takuya Hamakawa, Kazuhiro Nishikawa, Motohiro Hirao, Kei Yamamoto, Ayako Fujiwara, Sakae Maeda, Mamoru Uemura, Masakazu Miyake, Naoki Hama, Atsushi Miyamoto, Michihiko Miyazaki, Takeshi Kato, Koji Takami, Shoji Nakamori, Mitsugu Sekimoto
Here we report a case of a hemorrhagic gastric cancer patient with severe coronary artery disease, in whom the cancer was successfully resected with the support of intra-aortic balloon pumping(IABP). An 80-year-old man was referred to our hospital for further examination of his anemia and tumor around the pancreatic head. He was diagnosed with type 3 gastric cancer with multiple bulky lymph node metastases invadingto the pancreas(cT4b[LN-Panc], N3a, M1[LYM No.16a2int], cStage IV ). Tarry stools continued and blood transfusion was repeatedly required...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394800/-a-case-of-unresectable-locally-advanced-pancreatic-cancer-resulted-in-r0-surgery-after-chemotherapy
#11
Yu Sasaki, Hokahiro Katayama, Yohei Hosoda, Izumi Komoto, Takashi Sugimoto, Kazuhiro Yanagihara, Utae Katsushima, Jun Kawai, Hidenori Kiyochi, Kazuhiro Nishiyama, Asami Okabe, Yu Oshima, Shoji Tsunekawa, Nobuko Ogura, Yoshiro Taki
A 67-year-old man visited our hospital for jaundice. Abdominal dynamic CT showed the hypovascular tumor at the head of the pancreas that surrounded superior mesenteric artery(SMA)at an angle of 220 degree. No metastasis in lymph nodes and other organs was observed. We diagnosed the tumor unresectable locally advanced(UR-LA)pancreatic cancer. Chemotherapy was administered with gemcitabine and nab-paclitaxel(GEM+nab-PTX)and achieved partial response. Regression in size and in range around SMA to an angle of 150 was observed...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394738/-long-term-survivors-after-resection-for-primary-pancreatic-carcinoma-stage-iv
#12
Hironobu Makino, Hisashi Kametaka, Tadaomi Fukada, Takahiro Akiyama, Manabu Saitou, Shunsuke Tabe, Kazuhiro Seike
We discuss the prognosis of cases of Stage IV pancreatic carcinoma with distant metastases(7th Edition of General Rules for the Study of Pancreatic Cancer, Japan Pancreas Society)for which any treatment was performed at our hospital. Fiftythree patients were radiographically or pathologically diagnosed as having Stage IV pancreatic carcinoma with definite prognosis, and received treatments, includingsurg ery or chemotherapy, at our department. Twenty-two cases showed more metastases, and celiac artery or superior mesenteric artery invasion was suspected in 28 cases...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394692/-a-case-of-locally-advanced-neuroendocrine-carcinoma-of-the-stomach-could-be-curably-resected-after-chemotherapy-with-cpt-11-cddp
#13
Tomoki Kido, Yuta Morimoto, Hiroshi Toda, Kei Yoshino, Hiroshi Imano, Toshiki Sasaki, Yoshihiko Kimura, Reijiro Saito, Kazuhiko Endo
A 64-year-old man was admitted to our hospital because of epigastralgia. Gastrointestinal endoscopyrevealed a submucosal tumor with ulceration in the upper bodyof the stomach. The tumor was histologicallydiagnosed as a neuroendocrine carcinoma. CT showed that the tumor had directlyinfiltrated the pancreas and splenic vessels. The patient underwent onlyan exploratorylaparotomybecause the tumor seemed to involve the celiac artery. Chemotherapywas conducted using CPT-11/ CDDP. After 15 courses of chemotherapy, a significant tumor reduction was obtained...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394594/-multidisciplinary-therapy-with-gemcitabine-and-nab-paclitaxel-for-unresectable-pancreatic-cancer
#14
Fuyuhiko Motoi, Tatsuyuki Takadate, Shimpei Maeda, Kyohei Ariake, Kunihiro Masuda, Masaharu Ishida, Koji Fukase, Masamichi Mizuma, Hideo Ohtsuka, Naoaki Sakata, Hiroki Hayashi, Kei Nakagawa, Takanori Morikawa, Takeshi Naitoh, Michiaki Unno
Gemcitabine with nab-paclitaxel(GN)shows promisinganti -tumor effect and has been established standard regimen for metastatic pancreatic cancer(PC). Conversion surgery(CS), recently reported about initially unresectable PC with favorable response to non-surgical treatment, might provide long-term survival. The aim of this study is to evaluate the efficacy of multi-modal treatment includingCS after GN therapy for initially unresectable PC. From 2015 to 2016, 29 initially unresectable PC treated with chemotherapy includingGN were eligible for the retrospective analysis...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29391913/the-utility-of-fdg-pet-ct-in-igg4-related-disease-with-a-focus-on-coronary-artery-involvement
#15
Hian L Huang, Warren Fong, Wee M Peh, Kasat A Niraj, Winnie W Lam
Purpose: Our case series aims to study the growing use of FDG PET/CT in diagnostic evaluation and follow up of IgG4-RD with emphasis on patients presenting with coronary artery involvement. Methods: We conducted a search on the nuclear medicine and rheumatology service databases and identified patients with histologically proven IgG4-RD with FDG PET/CT performed at the Singapore General Hospital. The radiological, clinical, and laboratory findings of these patients were analyzed retrospectively...
February 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29388442/liver-function-assessment-by-indocyanine-green-plasma-disappearance-rate-in-patients-with-intra-abdominal-hypertension-after-non-hepatic-abdominal-surgery
#16
Natasa Kovac, Mladen Peric
BACKGROUND AND OBJECTIVE: Liver function assessment in patients with intra-abdominal hypertension (IAH) after major abdominal surgery is complex and often confounding. Elevated intra-abdominal pressure (IAP) often occurs after major abdominal surgery and is associated with decreased abdominal blood flow and organ dysfunction, and it could cause abdominal compartment syndrome (ACS), which is a life-threatening condition. Plasma disappearance rate (PDR) of indocyanine green (ICG) and ICG retention rate after 15 minutes (R15) were used to evaluate liver function and as a prognostic parameter after major abdominal surgery...
February 1, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29384897/significance-of-imaging-findings-in-the-diagnosis-of-heterotopic-spleen-an-intrapancreatic-accessory-spleen-ipas-case-report
#17
Bin Yang, Bimbadhar Valluru, Ya-Ru Guo, Chunmao Cui, Ping Zhang, Wenshuai Duan
RATIONALE: Accessory spleen (Heterotopic/Ectopic) or splenunculus has been attributed to the failure of the fusion of splenic primordial buds-derived from dorsal mesentery (mesodermal mesenchymal in origin) during the 5th week of embryonic organogenesis or to an extreme degree of splenic lobulation with pinching off of the spleen tissue. The most common locations for accessory spleens are the hilum of the spleen followed by adjacent to the tail of the pancreas. The patients usually present with no clinical symptoms...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29380119/granular-cell-tumor-of-the-pancreas-diagnosed-by-endoscopic-ultrasound-guided-fine-needle-aspiration
#18
Koji Takahashi, Rintaro Mikata, Toshio Tsuyuguchi, Junichiro Kumagai, Masato Nakamura, Yotaro Iino, Ayako Shingyoji, Mutsumi Yamato, Hiroshi Ohyama, Yuko Kusakabe, Shin Yasui, Harutoshi Sugiyama, Takashi Kishimoto, Yukio Nakatani, Naoya Kato
A 68-year-old woman was referred to our hospital for the treatment of bile duct stone, pancreatic tumor, and pancreatic cysts. First, bile duct stone was removed using endoscopic retrograde cholangiopancreatography. By abdominal contrast-enhanced computed tomography, a 12-mm diameter tumor was found in the pancreatic body. The tumor was isodense compared with the surrounding pancreatic parenchyma in the non-contrast phase and poorly enhanced in the arterial phase; it exhibited gradual enhancement from the portal vein phase to the late phase...
January 27, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29380102/circumportal-pancreas-prevalence-subtypes-and-vascular-variations-of-55-patients
#19
Erdem Yilmaz, Ahmet Celik
PURPOSE: To determine the frequency of circumportal pancreas (CP), and accompanying ductal and vascular anatomy variations. METHODS: Thin-section multidetector computed tomography of 6813 consecutive patients was retrospectively reviewed. Two radiologists evaluated CP presence with consensus. Concomitant pancreatic ductal and vascular variations were recorded. The course of the pancreatic duct was classified according to the portal vein as anteportal and retroportal, and pancreas fusion level classified according to splenic vein as suprasplenic, infrasplenic and mixed type...
January 27, 2018: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29362338/-a-resected-case-of-ur-la-pancreatic-tail-cancer-with-aortic-invasion-after-chemoradiotherapy
#20
Yu Fujimura, Masami Tabata, Tatsuya Sakamoto, Koki Maeda, Ichiro Ohsawa, Kenji Kato, Makoto Iwata, Takayuki Sanda
A 70-year-old male was referred to our hospital because of weight loss and epigastric discomfort. CT showed an irregularshaped, low-density tumor, 12 cm in diameter in the tail of the pancreas. This tumor widely invaded to the left kidney and to the anterior and left lateral sides of the aorta in spite of no involvement of celiac and superior mesenteric arteries. Moreover, it closely contacted with the stomach and the spleen. EUS-fine-needle aspiration biopsy of the tumor detected adenocarcinoma. Thus, he was diagnosed with UR-LA pancreatic cancer with aortic invasion...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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