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Bradley D Anawalt
No abstract text is available yet for this article.
July 2016: Journal of Clinical Endocrinology and Metabolism
Bradley D Anawalt, Stephanie T Page
No abstract text is available yet for this article.
August 2016: Lancet Diabetes & Endocrinology
S D Reed, K M Newton, J C Larson, C Booth-LaForce, N F Woods, C A Landis, E Tolentino, J S Carpenter, E W Freeman, H Joffe, B D Anawalt, K A Guthrie
OBJECTIVE: Diurnal salivary cortisol patterns in healthy adults are well established but have not been studied in midlife women with hot flashes. We hypothesized that frequent hot flashes are associated with aberrant cortisol patterns similar to sleep-deficient individuals. DESIGN: Cross-sectional. PARTICIPANTS: A total of 306 women, ages 40-62, randomized to a behavioural intervention for hot flashes. MEASUREMENTS: Baseline comparisons of cortisol geometric means (nmol/l) from four daily time points averaged over two consecutive days plus other calculated cortisol measures were made between groups defined by baseline: (i) mean daily hot flash frequency tertile (≤5·5, N = 103; >5·5-8·8, N = 103; >8·8, N = 100) and (ii) selected characteristics...
May 2016: Clinical Endocrinology
Ada P Lee, Mara Y Roth, Jean-Jacques Nya-Ngatchou, Kat Lin, Thomas J Walsh, Stephanie T Page, Alvin M Matsumoto, William J Bremner, John K Amory, Bradley D Anawalt
Measurement of intratesticular sex steroid concentrations in men informs both the development of male hormonal contraceptives and the understanding of male infertility. Given the challenges of using invasive techniques to measure testicular hormone physiology, our group has used a minimally-invasive fine-needle aspiration technique to measure intratesticular hormones in normal healthy men. Herein, we present a post-hoc analysis of the safety and efficacy of testicular fine-needle aspiration (FNA) completed as part of six clinical trials...
January 2016: Asian Journal of Andrology
Bradley D Anawalt, William J Bremner
No abstract text is available yet for this article.
September 2015: Nature Reviews. Endocrinology
Rachel Sparks, Alex H Salskov, Anita S Chang, Kelly L Wentworth, Pritha P Gupta, Thomas O Staiger, Bradley D Anawalt
BACKGROUND: Complete documentation of patient comorbidities in the medical record is important for clinical care, hospital reimbursement, and quality performance measures. We designed a pocket card reminder and brief educational intervention aimed at hospitalists with the goal of improving documentation of 6 common comorbidities present on admission: coagulation abnormalities, metastatic cancer, anemia, fluid and electrolyte abnormalities, malnutrition, and obesity. METHODS: Two internal medicine inpatient teams led by 10 hospitalist physicians at an academic medical center received the educational intervention and pocket card reminder (n = 520 admissions)...
April 2015: Quality Management in Health Care
Lori A Cooper, Stephanie T Page, John K Amory, Bradley D Anawalt, Alvin M Matsumoto
OBJECTIVE: Total testosterone concentrations are influenced by sex hormone-binding globulin (SHBG) concentrations, which are decreased by obesity and increased with ageing. Therefore, we sought to understand and compare the associations of ageing and obesity with SHBG. DESIGN: We performed a retrospective, cross-sectional analysis of the associations of obesity and age on SHBG and testosterone measurements in men being evaluated for hypogonadism. PATIENTS, MEASUREMENTS AND ANALYSIS: A total of 3671 men who underwent laboratory testing for testosterone deficiency from the Veterans Administration Puget Sound Health Care System from 1997 through 2007 was included...
December 2015: Clinical Endocrinology
John Bevan, John Newell-Price, Rebecca Reynolds, Wouter de Herder, Bradley Anawalt, Peter Ebeling, Steve Ball
No abstract text is available yet for this article.
May 2015: Clinical Endocrinology
Raghu Durvasula, Arkan Kayihan, Sherri Del Bene, Marion Granich, Grace Parker, Bradley D Anawalt, Thomas Staiger
In an environment where there is increased demand for hospital beds, it is important that inpatient flow from admission to treatment to discharge is optimized. Among the many drivers that impact efficient patient throughput is an effective and timely discharge process. Early morning discharge helps align inpatient capacity with clinical demand, thereby avoiding gridlock that adversely affects scheduled surgical procedures, diagnostic procedures, and therapies. At our large, academic medical center, we hypothesized that an interdisciplinary approach to scheduled discharge order entry would increase the percentage of discharges occurring before 11:00 AM and improve overall discharge time...
January 2015: Quality Management in Health Care
Ronald Swerdloff, Bradley D Anawalt
New England Journal of Medicine, Volume 371, Issue 21, Page 2032-2034, November 2014.
November 20, 2014: New England Journal of Medicine
Mathis Grossmann, Bradley D Anawalt, Frederick C W Wu
OBJECTIVE: To document current practices in the approach to low testosterone in older men. Given that recommendations are based on low-level evidence, we hypothesized that there would be a wide variability in clinical practice patterns. DESIGN: Members of all major endocrine and andrological societies were invited to participate in a Web-based survey of the diagnostic work-up and management of a hypothetical index case of a 61-year old overweight man presenting with symptoms suggestive of androgen deficiency, without evidence of hypothalamic-pituitary-gonadal (HPT) axis disease...
February 2015: Clinical Endocrinology
Bradley D Anawalt
No abstract text is available yet for this article.
January 2014: Journal of Clinical Endocrinology and Metabolism
Bradley D Anawalt
Male subfertility is common, and it causes significant duress to couples. Although the most common cause of male subfertility is idiopathic failure of spermatogenesis, a significant percentage of male subfertility is medically treatable. Compared to reproductive specialists, endocrinologists may see a population of men that have a higher prevalence of treatable causes of subfertility including sexual disorders, endocrinopathies, obesity, drugs, and ejaculatory dysfunction. Seminal fluid analysis is the most important diagnostic study, and at least 2 samples should be analyzed...
September 2013: Journal of Clinical Endocrinology and Metabolism
M Y Roth, J J S Nya-Ngatchou, K Lin, S T Page, B D Anawalt, A M Matsumoto, B T Marck, W J Bremner, J K Amory
CONTEXT: The concentration of intratesticular testosterone (IT-T) required for human spermatogenesis is unknown because spermatogenesis can persist despite the markedly reduced IT-T concentrations observed with LH suppression. Methods to lower IT-T further are needed to determine the relationship between IT-T and spermatogenesis. OBJECTIVE: The objective of the study was to determine the effect of inhibiting the synthesis and metabolism of testosterone (T) on IT-T in gonadotropin-suppressed human testes...
March 2013: Journal of Clinical Endocrinology and Metabolism
Bradley D Anawalt
No abstract text is available yet for this article.
March 2013: Asian Journal of Andrology
Mara Y Roth, Kat Lin, Katrine Bay, John K Amory, Bradley D Anawalt, Alvin M Matsumoto, Brett T Marck, William J Bremner, Stephanie T Page
OBJECTIVE: To study the potential role for using serum biomarkers, including insulin-like factor 3 (INSL3), 17α-hydroxyprogesterone, antimüllerian hormone, and inhibin B, as correlates of intratesticular T (IT-T) concentrations in men. DESIGN: Prospective, randomized, controlled trial. SETTING: University-based medical center. PATIENT(S): Thirty-seven healthy men aged 18-50 years. INTERVENTION(S): All men received the GnRH antagonist acyline, plus very low doses of hCG (0 IU, 15 IU, 60 IU, or 125 IU) SC every other day or 7...
January 2013: Fertility and Sterility
Molly M Shores, Nicholas L Smith, Christopher W Forsberg, Bradley D Anawalt, Alvin M Matsumoto
CONTEXT: Low testosterone levels in men have been associated with increased mortality. However, the influence of testosterone treatment on mortality in men with low testosterone levels is not known. OBJECTIVE: The objective of the study was to examine the association between testosterone treatment and mortality in men with low testosterone levels. DESIGN: This was an observational study of mortality in testosterone-treated compared with untreated men, assessed with time-varying, adjusted Cox proportional hazards regression models...
June 2012: Journal of Clinical Endocrinology and Metabolism
Marwa Shoeb, Susan Eva Merel, Molly Blackley Jackson, Bradley D Anawalt
BACKGROUND: Studies show that hospitalized patients often do not understand their postdischarge care plan. There are few studies about patients' preferences regarding the content of discharge care plans. OBJECTIVE: To identify what patients view as essential elements of a post-hospitalization plan. DESIGN: Anonymous written survey distributed on the second day of admission to internal medicine wards. SETTING: An academic tertiary care hospital and an academic county hospital in Seattle, Washington...
July 2012: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
Bradley D Anawalt, James M Hotaling, Thomas J Walsh, Alvin M Matsumoto
PURPOSE: Guidelines recommend serum total testosterone measurement as the initial test to evaluate male hypogonadism, reserving free testosterone assessment for men with suspected sex hormone-binding globulin abnormalities or total testosterone near the lower limit of normal. We determined the performance of total testosterone measurement as a test to identify men with normal vs low free testosterone. MATERIALS AND METHODS: We examined the electronic medical records of all 3,672 men evaluated for hypogonadism by a serum testosterone panel, including total testosterone, sex hormone-binding globulin, albumin and calculated free testosterone, from January 1, 1997 through December 31, 2007 in a network that serves veterans in Washington...
April 2012: Journal of Urology
Jason P Etzel, Meaghan F Larson, Bradley D Anawalt, Judith Collins, Jason A Dominitz
BACKGROUND: Inflammatory bowel disease (IBD) patients have increased prevalence of osteoporosis, leading to guideline recommendations for bone mineral density (BMD) testing. The study aim was to identify predictors of BMD testing and treatment and assess guideline effectiveness to identify IBD patients with osteoporosis. METHODS: Records of all IBD patients at seven medical facilities were reviewed for clinical data and BMD testing from January 1996 through October 2006...
October 2011: Inflammatory Bowel Diseases
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