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https://www.readbyqxmd.com/read/28582536/is-dihydrotestosterone-a-classic-hormone
#1
Bradley D Anawalt
No abstract text is available yet for this article.
June 1, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/28265377/high-concentrations-of-lh-cause-virilization-in-a-postmenopausal-woman
#2
Iram Ahmad, Bradley D Anawalt
Some testosterone-producing adrenal tumors can be successfully treated with long-acting GnRH analogs and adrenal venous sampling can be useful to detect rare ectopic sex steroid-producing tumors or confirm bilateral adrenal androgen hyperproduction in female hyperandrogenism.
March 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/27381959/the-model-t
#3
Bradley D Anawalt
No abstract text is available yet for this article.
July 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27377543/testosterone-and-the-brain-the-power-of-a-negative-study
#4
Bradley D Anawalt, Stephanie T Page
No abstract text is available yet for this article.
August 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/26663024/daily-salivary-cortisol-patterns-in-midlife-women-with-hot-flashes
#5
RANDOMIZED CONTROLLED TRIAL
S D Reed, K M Newton, J C Larson, C Booth-LaForce, N F Woods, C A Landis, E Tolentino, J S Carpenter, E W Freeman, H Joffe, B D Anawalt, K A Guthrie
OBJECTIVE: Diurnal salivary cortisol patterns in healthy adults are well established but have not been studied in midlife women with hot flashes. We hypothesized that frequent hot flashes are associated with aberrant cortisol patterns similar to sleep-deficient individuals. DESIGN: Cross-sectional. PARTICIPANTS: A total of 306 women, ages 40-62, randomized to a behavioural intervention for hot flashes. MEASUREMENTS: Baseline comparisons of cortisol geometric means (nmol/l) from four daily time points averaged over two consecutive days plus other calculated cortisol measures were made between groups defined by baseline: (i) mean daily hot flash frequency tertile (≤5·5, N = 103; >5·5-8·8, N = 103; >8·8, N = 100) and (ii) selected characteristics...
May 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/26208394/testicular-fine-needle-aspiration-for-the-assessment-of-intratesticular-hormone-concentrations
#6
Ada P Lee, Mara Y Roth, Jean-Jacques Nya-Ngatchou, Kat Lin, Thomas J Walsh, Stephanie T Page, Alvin M Matsumoto, William J Bremner, John K Amory, Bradley D Anawalt
Measurement of intratesticular sex steroid concentrations in men informs both the development of male hormonal contraceptives and the understanding of male infertility. Given the challenges of using invasive techniques to measure testicular hormone physiology, our group has used a minimally-invasive fine-needle aspiration technique to measure intratesticular hormones in normal healthy men. Herein, we present a post-hoc analysis of the safety and efficacy of testicular fine-needle aspiration (FNA) completed as part of six clinical trials...
January 2016: Asian Journal of Andrology
https://www.readbyqxmd.com/read/26149613/reproductive-endocrinology-are-intramuscular-testosterone-injections-harmful
#7
COMMENT
Bradley D Anawalt, William J Bremner
No abstract text is available yet for this article.
September 2015: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/25830615/pocket-change-a-simple-educational-intervention-increases-hospitalist-documentation-of-comorbidities-and-improves-hospital-quality-performance-measures
#8
COMPARATIVE STUDY
Rachel Sparks, Alex H Salskov, Anita S Chang, Kelly L Wentworth, Pritha P Gupta, Thomas O Staiger, Bradley D Anawalt
BACKGROUND: Complete documentation of patient comorbidities in the medical record is important for clinical care, hospital reimbursement, and quality performance measures. We designed a pocket card reminder and brief educational intervention aimed at hospitalists with the goal of improving documentation of 6 common comorbidities present on admission: coagulation abnormalities, metastatic cancer, anemia, fluid and electrolyte abnormalities, malnutrition, and obesity. METHODS: Two internal medicine inpatient teams led by 10 hospitalist physicians at an academic medical center received the educational intervention and pocket card reminder (n = 520 admissions)...
April 2015: Quality Management in Health Care
https://www.readbyqxmd.com/read/25777143/the-association-of-obesity-with-sex-hormone-binding-globulin-is-stronger-than-the-association-with-ageing-implications-for-the-interpretation-of-total-testosterone-measurements
#9
Lori A Cooper, Stephanie T Page, John K Amory, Bradley D Anawalt, Alvin M Matsumoto
OBJECTIVE: Total testosterone concentrations are influenced by sex hormone-binding globulin (SHBG) concentrations, which are decreased by obesity and increased with ageing. Therefore, we sought to understand and compare the associations of ageing and obesity with SHBG. DESIGN: We performed a retrospective, cross-sectional analysis of the associations of obesity and age on SHBG and testosterone measurements in men being evaluated for hypogonadism. PATIENTS, MEASUREMENTS AND ANALYSIS: A total of 3671 men who underwent laboratory testing for testosterone deficiency from the Veterans Administration Puget Sound Health Care System from 1997 through 2007 was included...
December 2015: Clinical Endocrinology
https://www.readbyqxmd.com/read/25740322/clinical-endocrinology-education-project-a-tribute-to-professor-steve-judd
#10
EDITORIAL
John Bevan, John Newell-Price, Rebecca Reynolds, Wouter de Herder, Bradley Anawalt, Peter Ebeling, Steve Ball
No abstract text is available yet for this article.
May 2015: Clinical Endocrinology
https://www.readbyqxmd.com/read/25539490/a-multidisciplinary-care-pathway-significantly-increases-the-number-of-early-morning-discharges-in-a-large-academic-medical-center
#11
Raghu Durvasula, Arkan Kayihan, Sherri Del Bene, Marion Granich, Grace Parker, Bradley D Anawalt, Thomas Staiger
In an environment where there is increased demand for hospital beds, it is important that inpatient flow from admission to treatment to discharge is optimized. Among the many drivers that impact efficient patient throughput is an effective and timely discharge process. Early morning discharge helps align inpatient capacity with clinical demand, thereby avoiding gridlock that adversely affects scheduled surgical procedures, diagnostic procedures, and therapies. At our large, academic medical center, we hypothesized that an interdisciplinary approach to scheduled discharge order entry would increase the percentage of discharges occurring before 11:00 AM and improve overall discharge time...
January 2015: Quality Management in Health Care
https://www.readbyqxmd.com/read/25409377/clinical-decisions-testosterone-replacement-therapy
#12
Ronald Swerdloff, Bradley D Anawalt
New England Journal of Medicine, Volume 371, Issue 21, Page 2032-2034, November 2014.
November 20, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/25154540/clinical-practice-patterns-in-the-assessment-and-management-of-low-testosterone-in-men-an-international-survey-of-endocrinologists
#13
Mathis Grossmann, Bradley D Anawalt, Frederick C W Wu
OBJECTIVE: To document current practices in the approach to low testosterone in older men. Given that recommendations are based on low-level evidence, we hypothesized that there would be a wide variability in clinical practice patterns. DESIGN: Members of all major endocrine and andrological societies were invited to participate in a Web-based survey of the diagnostic work-up and management of a hypothetical index case of a 61-year old overweight man presenting with symptoms suggestive of androgen deficiency, without evidence of hypothalamic-pituitary-gonadal (HPT) axis disease...
February 2015: Clinical Endocrinology
https://www.readbyqxmd.com/read/24384017/is-men-s-health-just-a-single-letter
#14
EDITORIAL
Bradley D Anawalt
No abstract text is available yet for this article.
January 2014: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24014811/approach-to-male-infertility-and-induction-of-spermatogenesis
#15
REVIEW
Bradley D Anawalt
Male subfertility is common, and it causes significant duress to couples. Although the most common cause of male subfertility is idiopathic failure of spermatogenesis, a significant percentage of male subfertility is medically treatable. Compared to reproductive specialists, endocrinologists may see a population of men that have a higher prevalence of treatable causes of subfertility including sexual disorders, endocrinopathies, obesity, drugs, and ejaculatory dysfunction. Seminal fluid analysis is the most important diagnostic study, and at least 2 samples should be analyzed...
September 2013: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/23348398/androgen-synthesis-in-the-gonadotropin-suppressed-human-testes-can-be-markedly-suppressed-by-ketoconazole
#16
RANDOMIZED CONTROLLED TRIAL
M Y Roth, J J S Nya-Ngatchou, K Lin, S T Page, B D Anawalt, A M Matsumoto, B T Marck, W J Bremner, J K Amory
CONTEXT: The concentration of intratesticular testosterone (IT-T) required for human spermatogenesis is unknown because spermatogenesis can persist despite the markedly reduced IT-T concentrations observed with LH suppression. Methods to lower IT-T further are needed to determine the relationship between IT-T and spermatogenesis. OBJECTIVE: The objective of the study was to determine the effect of inhibiting the synthesis and metabolism of testosterone (T) on IT-T in gonadotropin-suppressed human testes...
March 2013: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/23334198/the-silent-spermatozoon-are-man-made-endocrine-disruptors-killing-male-fertility
#17
REVIEW
Bradley D Anawalt
No abstract text is available yet for this article.
March 2013: Asian Journal of Andrology
https://www.readbyqxmd.com/read/23040523/serum-insulin-like-factor-3-is-highly-correlated-with-intratesticular-testosterone-in-normal-men-with-acute-experimental-gonadotropin-deficiency-stimulated-with-low-dose-human-chorionic-gonadotropin-a-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Mara Y Roth, Kat Lin, Katrine Bay, John K Amory, Bradley D Anawalt, Alvin M Matsumoto, Brett T Marck, William J Bremner, Stephanie T Page
OBJECTIVE: To study the potential role for using serum biomarkers, including insulin-like factor 3 (INSL3), 17α-hydroxyprogesterone, antimüllerian hormone, and inhibin B, as correlates of intratesticular T (IT-T) concentrations in men. DESIGN: Prospective, randomized, controlled trial. SETTING: University-based medical center. PATIENT(S): Thirty-seven healthy men aged 18-50 years. INTERVENTION(S): All men received the GnRH antagonist acyline, plus very low doses of hCG (0 IU, 15 IU, 60 IU, or 125 IU) SC every other day or 7...
January 2013: Fertility and Sterility
https://www.readbyqxmd.com/read/22496507/testosterone-treatment-and-mortality-in-men-with-low-testosterone-levels
#19
Molly M Shores, Nicholas L Smith, Christopher W Forsberg, Bradley D Anawalt, Alvin M Matsumoto
CONTEXT: Low testosterone levels in men have been associated with increased mortality. However, the influence of testosterone treatment on mortality in men with low testosterone levels is not known. OBJECTIVE: The objective of the study was to examine the association between testosterone treatment and mortality in men with low testosterone levels. DESIGN: This was an observational study of mortality in testosterone-treated compared with untreated men, assessed with time-varying, adjusted Cox proportional hazards regression models...
June 2012: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/22447649/-can-we-just-stop-and-talk-patients-value-verbal-communication-about-discharge-care-plans
#20
Marwa Shoeb, Susan Eva Merel, Molly Blackley Jackson, Bradley D Anawalt
BACKGROUND: Studies show that hospitalized patients often do not understand their postdischarge care plan. There are few studies about patients' preferences regarding the content of discharge care plans. OBJECTIVE: To identify what patients view as essential elements of a post-hospitalization plan. DESIGN: Anonymous written survey distributed on the second day of admission to internal medicine wards. SETTING: An academic tertiary care hospital and an academic county hospital in Seattle, Washington...
July 2012: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
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