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lupus and pregnan

Lorraine Maitrot-Mantelet, Anahid Agopian, Anne Gompel
Synthetic progestogens belong to different pharmacological classes and are mixed steroids. They display different properties due to their various affinities to the different steroid receptors. In addition, the dosage used can modify their side effects. Normethyltestosterone used at minimal doses, also called progestogen only pill (POP), constitute the standard recommended hormonal contraception for women with vascular and metabolic contraindications to combined pill (COC). However, POP efficacy and gynecological tolerance are limited...
December 1, 2010: Hormone Molecular Biology and Clinical Investigation
Nathalie Chabbert-Buffet, Zahir Amoura, Pierre-Yves Scarabin, Camille Frances, Delphine P Lévy, Lionel Galicier, Bertrand Wechsler, Olivier Blétry, Jean-Charles Piette, Anne Gompel
BACKGROUND: Systemic lupus erythematosus (SLE) affects women of child-bearing age. Combined oral contraceptives can worsen the course and increase the risk of thrombosis. The objectives of this study were to provide an alternative contraception and thus evaluate the gynecological tolerability of pregnane progestins (PPs) in SLE patients. Systemic lupus erythematosus disease activity and vascular tolerance were also reported. STUDY DESIGN: We used two PP with antigonadotropic potencies, chlormadinone acetate (CMA, 10 mg/day) and cyproterone acetate (CPA, 50 mg/day), administered orally for contraception in 187 SLE patients observed for 46±34...
March 2011: Contraception
A Gompel, J C Piette
The Women Health Initiative (WHI) randomized trials have reported increase in cardiovascular and breast cancer risks from the use of post-menopausal hormone therapy (HT). A striking decrease of HT use has been observed worldwide despite the fact that other regimens in younger post-menopausal women could be safer. Systemic lupus erythematosis (SLE) is considered as estrogen sensitive. HT is generally considered as contraindicated in these women who are especially at risk for cardiovascular diseases and osteoporosis...
September 2008: Panminerva Medica
A Gompel, J C Piette
The indications for hormone replacement therapy (HRT) in postmenopausal women is the treatment of climacteric symptoms and the prevention of osteoporosis. Women with systemic lupus erythematosus (SLE) are more likely to have a premature menopause, osteoporosis and cardiovascular disease. HRT can induce SLE flares and cardiovascular or venous thromboembolic events. Therefore it should not be used in women with active disease or those with antiphospholipid (aPL) antibodies. In general, it should be used only for patients without active disease, a history of thrombosis or aPL antibodies...
June 2007: Menopause International
V Costea, M Munteu
No abstract text is available yet for this article.
April 1969: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
E Radha, D Schönberg, J R Bierich
No abstract text is available yet for this article.
September 1967: Arzneimittel-Forschung
L Sinka, T Danilla
No abstract text is available yet for this article.
April 1971: Ceskoslovenská Dermatologie
H Kerl, G Klein, M Sandhofer
No abstract text is available yet for this article.
November 23, 1973: Wiener Klinische Wochenschrift
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