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https://www.readbyqxmd.com/read/28054519/radioiodine-as-an-adjuvant-therapy-and-its-role-in-follow-up-of-differentiated-thyroid-cancer
#1
REVIEW
S Padma, P Shanmuga Sundaram
Papillary and follicular cancers of thyroid are the most common varieties of differentiated thyroid cancers exhibiting excellent long-term prognosis when carefully managed. Being a slow-growing malignancy, guidelines exist on the staging, preoperative risk stratification, and management of these cancers to increase the overall survival of these patients. Radioactive iodine has a central role in differentiated thyroid malignancies. It has the same physical properties as stable iodine, thus both normal and malignant thyrocytes cannot differentiate radioactive from stable iodine...
July 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28007583/towards-a-privacy-preserving-cohort-discovery-framework-for-clinical-research-networks
#2
Jiawei Yuan, Bradley Malin, François Modave, Yi Guo, William R Hogan, Elizabeth Shenkman, Jiang Bian
BACKGROUND: The last few years have witnessed an increasing number of clinical research networks (CRNs) focused on building large collections of data from electronic health records (EHRs), claims, and patient-reported outcomes (PROs). Many of these CRNs provide a service for the discovery of research cohorts with various health conditions, which is especially useful for rare diseases. Supporting patient privacy can enhance the scalability and efficiency of such processes; however, current practice mainly relies on policy, such as guidelines defined in the Health Insurance Portability and Accountability Act (HIPAA), which are insufficient for CRNs (e...
December 19, 2016: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/27909825/poor-outcomes-of-gastric-cancer-surgery-after-admission-through-the-emergency-department
#3
Ian Solsky, Patricia Friedmann, Peter Muscarella, Haejin In
BACKGROUND: Outcomes after nonelective surgery for gastric cancer (GC) are poorly defined. Our objective was to compare outcomes of patients undergoing nonelective GC surgery after admission through the emergency department (EDSx) with patients receiving elective surgery or surgery after planned admission (non-EDSx) nationally. METHODS: The Nationwide Inpatient Sample (NIS) database was used to examine patients undergoing GC surgery between 2008 and 2012. Demographics and outcomes were compared between EDSx and non-EDSx...
December 1, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27876589/usa-hospitalizations-for-malignant-pleural-effusions-data-from-the-2012-national-inpatient-sample
#4
Niloofar Taghizadeh, Marc Fortin, Alain Tremblay
BACKGROUND: Malignant pleural effusions (MPE) are a common complication of advanced malignancy, but little is known regarding their prevalence and overall burden on a population level. METHODS: We conducted a retrospective analysis of MPE associated hospitalizations using the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample, Agency for Healthcare Research and Quality (HCUP-NIS 2012). Cases were included if MPE was coded as a primary or secondary diagnosis or if an unspecified pleural effusion was coded in addition to a diagnosis of cancer with either of these being the primary diagnosis...
November 19, 2016: Chest
https://www.readbyqxmd.com/read/27846192/crohn-s-disease-is-associated-with-the-risk-for-thyroid-cancer
#5
Vaibhav Wadhwa, Rocio Lopez, Bo Shen
BACKGROUND: It is known that inflammatory bowel disease (IBD) is associated with a high risk for some of extraintestinal cancers. The aim of this study was to identify whether IBD is associated with thyroid cancer using a large national database. METHODS: We performed a case-control study using the 2012 National Inpatient Sample (NIS) database. The study group included all patients with Crohn's disease (CD) (ICD-9 Code: 555) and ulcerative colitis (UC) (ICD-9 Code: 556), and the control group included all patients with diverticulitis (ICD-9 Code: 562...
December 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27805390/insights-of-a-lead-optimization-study-and-biological-evaluation-of-novel-4-hydroxytamoxifen-analogs-as-estrogen-related-receptor-%C3%AE-err%C3%AE-inverse-agonists
#6
Jina Kim, Seo Yeon Woo, Chun Young Im, Eun Kyung Yoo, Seungmi Lee, Hyo-Ji Kim, Hee-Jong Hwang, Joong-Heui Cho, Won Seok Lee, Heeseok Yoon, Shinae Kim, Oh-Bin Kwon, Hayoung Hwang, Kyung-Hee Kim, Jae-Han Jeon, Thoudam Debraj Singh, Sang Wook Kim, Sung Yeoun Hwang, Hueng-Sik Choi, In-Kyu Lee, Seong Heon Kim, Yong Hyun Jeon, Jungwook Chin, Sung Jin Cho
We evaluated the in vitro pharmacology as well as the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of chemical entities that not only were shown to be highly selective agonists for ERRγ but also exhibited enhanced pharmacokinetic profile compared with 3 (GSK5182). 6g and 10b had comparable potency to 3 and were far more selective for ERRγ over the ERRα, -β, and ERα. The in vivo pharmacokinetic profiles of 6g and 10b were further evaluated, as they possessed superior in vitro ADMET profiles compared to the other compounds...
November 23, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27785538/cholinergic-pet-imaging-in-infections-and-inflammation-using-11-c-donepezil-and-18-f-feobv
#7
Nis Pedersen Jørgensen, Aage K O Alstrup, Frank V Mortensen, Karoline Knudsen, Steen Jakobsen, Line Bille Madsen, Dirk Bender, Peter Breining, Mikkel Steen Petersen, Mariane Høgsberg Schleimann, Frederik Dagnæs-Hansen, Lars C Gormsen, Per Borghammer
INTRODUCTION: Immune cells utilize acetylcholine as a paracrine-signaling molecule. Many white blood cells express components of the cholinergic signaling pathway, and these are up-regulated when immune cells are activated. However, in vivo molecular imaging of cholinergic signaling in the context of inflammation has not previously been investigated. METHODS: We performed positron emission tomography (PET) using the glucose analogue 18F-FDG, and 11C-donepezil and 18F-FEOBV, markers of acetylcholinesterase and the vesicular acetylcholine transporter, respectively...
October 26, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27782084/measles-to-the-rescue-a-review-of-oncolytic-measles-virus
#8
REVIEW
Sarah Aref, Katharine Bailey, Adele Fielding
Oncolytic virotherapeutic agents are likely to become serious contenders in cancer treatment. The vaccine strain of measles virus is an agent with an impressive range of oncolytic activity in pre-clinical trials with increasing evidence of safety and efficacy in early clinical trials. This paramyxovirus vaccine has a proven safety record and is amenable to careful genetic modification in the laboratory. Overexpression of the measles virus (MV) receptor CD46 in many tumour cells may direct the virus to preferentially enter transformed cells and there is increasing awareness of the importance of nectin-4 and signaling lymphocytic activation molecule (SLAM) in oncolysis...
October 22, 2016: Viruses
https://www.readbyqxmd.com/read/27777043/trends-in-hospitalization-and-mortality-of-venous-thromboembolism-in-hospitalized-patients-with-colon-cancer-and-their-outcomes-us-perspective
#9
Kalpit Devani, Nirav Patil, Carlos Roberto Simons-Linares, Nilay Patel, Palashkumar Jaiswal, Pranav Patel, Samir Patel, Chirag Savani, Kamlesh Sajnani, Mark Young, Chakradhar Reddy
INTRODUCTION: Venous thromboembolism (VTE) is a major cause of morbidity and mortality in hospitalized patients with colon cancer. We assessed nationwide population-based trends in rates of hospitalization and mortality from VTE among patients with colon cancer to determine its impact. METHODS: We queried the Nationwide Inpatient Sample (NIS) database entries from 2003 to 2011 to identify patients with colon cancer. Bivariate group comparisons between hospitalized patients with colon cancer with VTE to those without VTE were made...
September 20, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27765561/impact-of-parkinson-s-disease-on-perioperative-complications-and-hospital-cost-in-multilevel-spine-fusion-a-population-based-analysis
#10
Shearwood McClelland, Joseph F Baker, Justin S Smith, Breton G Line, Thomas J Errico, Christopher P Ames, R Shay Bess
Parkinson's disease (PD) is a neurodegenerative disorder manifesting over time to result in reduced mobility. The impact of PD on spinal fusion has yet to be addressed on a nationwide level. The Nationwide Inpatient Sample (NIS) from 2001 to 2012 was used for analysis. Admissions with spinal fusion of two or more vertebrae (ICD-9 codes=81.62, 81.63 and 81.64) were included and then stratified based on the presence or absence of PD (ICD-9 code=332.0); patients with cancer (ICD-9 codes=140-239) or trauma (ICD-9 codes=805...
January 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27721275/evaluation-of-pathological-parameters-and-morphometric-data-of-desmoplastic-lobular-breast-carcinoma
#11
Ivan R Ilic, Nikola M Stojanović, Pavle J Randjelović, Marina N Mihajlović, Niko S Radulović, Ratko S Ilić
BACKGROUND: Invasive lobular breast cancer (ILC) is the second most frequent form of breast cancer. While cancer cells are regularly investigated, tumor stroma represents a highly unexplored field. AIMS: The aim of this study is to perform a detailed investigation of clinical, immunohistochemical, and morphometric characteristics of desmoplastic (D) and nondesmoplastic (ND) ILC. MATERIALS AND METHODS: This study included twenty cases of ILC that were divided into two groups designated as D and ND groups...
October 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/27685523/correlation-of-iodine-symporter-expression-in-highly-and-low-malignant-cell-lines-of-human-breast-cancer-differed-in-their-sensitivity-to-doxorubicin
#12
N Yu Lukianova, A V Andriiv, V F Chekhun
UNLABELLED: To investigate the relationship of sodium/iodide symporter (NIS) expression with molecular phenotype of highly and low malignant cell lines of human breast cancer (BC) with different sensitivity to doxorubicin (Dox). MATERIALS AND METHODS: The cell lines used in the analysis included T47D, MCF-7, MDA-MB-231, MDA-MB-468, and MCF/Dox. NIS expression was studied by immunocytochemical method. RESULTS: The strongest iodine symporter expression (248 ± 1...
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27651890/trends-in-annual-drug-expenditure-a-16-year-perspective-of-a-public-healthcare-maintenance-organization
#13
Yossef Lomnicky, Daniel Kurnik, Ronen Loebstein, Itzhak Katzir, Janet Vesterman-Landes, Nava Siegelmann-Danieli
BACKGROUND: Modern drug therapy accounts for a major share of health expenditure and challenges public provider resources. The objective of our study was to compare drug expenditure trends for ten major drug classes over 16 years at Maccabi Healthcare Services (MHS), the 2(nd) largest healthcare organization in Israel. METHODS: A retrospective analysis of drug expenditure per HMO beneficiary between the years 1998-2014. Trends in annual mean drug expenditures per MHS member were compared among 10 major drug classes...
2016: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/27638195/thyrotropin-and-insulin-like-growth-factor-1-receptor-crosstalk-upregulates-sodium-iodide-symporter-expression-in-primary-cultures-of-human-thyrocytes
#14
Sarah J Morgan, Susanne Neumann, Bernice Marcus-Samuels, Marvin C Gershengorn
BACKGROUND: Major regulation of thyroid gland function is mediated by thyrotropin (TSH) activating the TSH receptor (TSHR) and inducing upregulation of genes involved in thyroid hormone synthesis. Evidence suggests that the insulin-like growth factor 1 (IGF-1) receptor (IGF-1R) may play a role in regulating TSHR functional effects. This study examined the potential role of TSHR/IGF-1R crosstalk in primary cultures of human thyrocytes. RESULTS: TSH/IGF-1 co-treatment elicited additive effects on thyroglobulin (TG), thyroperoxidase (TPO), and deiodinase type 2 (DIO2) mRNA levels but synergistic effects on sodium-iodide symporter (NIS) mRNA...
December 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27616592/emerging-integrated-nanoclay-facilitated-drug-delivery-system-for-papillary-thyroid-cancer-therapy
#15
Yi Zhang, Mei Long, Peng Huang, Huaming Yang, Shi Chang, Yuehua Hu, Aidong Tang, Linfeng Mao
Nanoclay can be incorporated into emerging dual functional drug delivery systems (DDSs) to promote efficiency in drug delivery and reduce the toxicity of doxorubicin (DOX) used for thyroid cancer treatment. This paper reports the expansion of the basal spacing of kaolinite nanoclay was expanded from 0.72 nm to 0.85 nm, which could provide sufficiently spacious site for hosting doxorubicin molecules and controlling the diffusion rate. A targeted design for papillary thyroid cancer cells was achieved by introducing KI, which is consumed by the sodium-iodide symporter (NIS)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27608773/small-activating-rna-upregulates-nis-expression-promising-potential-for-hepatocellular-carcinoma-endoradiotherapy
#16
W Xia, D Li, G Wang, J Ni, J Zhuang, M Ha, J Wang, Y Ye
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Currently, the clinical strategies available for the treatment of HCC remain insufficient for the poor prognosis. Sodium/iodide symporter (NIS)-based radioiodine therapy is proposed as a promising therapeutic strategy for the treatment of HCC. However, it is difficult for HCC cells to trap iodine for the lower expression of NIS. Small activating RNA (saRNA) is a newly identified small double-stranded RNA (dsRNA) that can induce endogenous gene expression by targeting promoter sequences...
September 9, 2016: Cancer Gene Therapy
https://www.readbyqxmd.com/read/27573304/use-of-rhenium-188-for-in-vivo-imaging-and-treatment-of-human-cervical-cancer-cells-transfected-with-lentivirus-expressing-sodium-iodide-symporter
#17
Min Zhang, Shuo Shi, Rui Guo, Yin Miao, Biao Li
Although survival rates for cervical cancer have improved, they need further improvement in patients with distant metastases. The sodium iodine symporter (NIS) gene has often been used in cancer therapy and imaging. We examined the therapeutic effects of rhenium-188 (188Re) in a cervical cancer xenograft model expressing the NIS gene under the control of the tumor-specific human telomerase reverse transcriptase (hTERT) promoter. We constructed two recombinant lentiviral vectors expressing enhanced green fluorescent protein (eGFP) or the NIS gene driven by the hTERT promoter...
October 2016: Oncology Reports
https://www.readbyqxmd.com/read/27561081/national-regional-state-and-selected-local-area-vaccination-coverage-among-adolescents-aged-13-17-years-united-states-2015
#18
Sarah Reagan-Steiner, David Yankey, Jenny Jeyarajah, Laurie D Elam-Evans, C Robinette Curtis, Jessica MacNeil, Lauri E Markowitz, James A Singleton
The Advisory Committee on Immunization Practices (ACIP) recommends that adolescents aged 11-12 years routinely receive vaccines to prevent diseases, including human papillomavirus (HPV)-associated cancers, pertussis, and meningococcal disease (1). To assess vaccination coverage among adolescents in the United States, CDC analyzed data collected regarding 21,875 adolescents through the 2015 National Immunization Survey-Teen (NIS-Teen).* During 2014-2015, coverage among adolescents aged 13-17 years increased for each HPV vaccine dose among males, including ≥1 HPV vaccine dose (from 41...
August 26, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27542965/trends-in-hospice-discharge-documented-inpatient-palliative-care-services-and-inpatient-mortality-in-ovarian-carcinoma
#19
Shitanshu Uppal, Laurel W Rice, Anurag Beniwal, Ryan J Spencer
OBJECTIVE: To investigate the trends in discharge to hospice, documented inpatient palliative care services, and inpatient mortality in metastatic ovarian cancer (mOvCa) patients. METHODS: Patients≥18years with mOvCa and a non-elective admission between January 1, 2006 and December 31, 2011 were identified from the National Inpatient Sample (NIS). The primary outcome of interest was the temporal trend in the annual proportion of hospitalizations for mOvCa where discharge destination was hospice...
August 16, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27532609/safety-studies-in-tumor-and-non-tumor-bearing-mice-in-support-of-clinical-trials-using-oncolytic-vsv-ifn%C3%AE-nis
#20
Lianwen Zhang, Michael B Steele, Nathan Jenks, Jacquelyn Grell, Lukkana Suksanpaisan, Shruthi Naik, Mark J Federspiel, Martha Q Lacy, Stephen J Russell, Kah-Whye Peng
Oncolytic VSV-IFNβ-NIS is selectively destructive to tumors. Here, we present the IND enabling preclinical rodent studies in support of clinical testing of vesicular stomatitis virus (VSV) as a systemic therapy. Efficacy studies showed dose-dependent tumor regression in C57BL/KaLwRij mice bearing syngeneic 5TGM1 plasmacytomas after systemic VSV administration. In contrast, the virus was effective at all doses tested against human KAS6/1 xenografts in SCID mice. Intravenous administration of VSV-mIFNβ-NIS is well tolerated in C57BL/6 mice up to 5 × 10(10) TCID50 (50% tissue culture infective dose)/kg with no neurovirulence, no cytokine storm, and no abnormalities in tissues...
September 2016: Human Gene Therapy. Clinical Development
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