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https://www.readbyqxmd.com/read/29620212/larp7-in-papillary-thyroid-carcinoma-induces-nis-expression-through-suppression-of-the-shh-signaling-pathway
#1
Xiaomei Sui, Yana Sui, Yonghui Wang
The incidence of thyroid cancer has increased the past few decades, the most frequent type has been identified to be the papillary thyroid carcinoma (PTC). Following thyroidectomy, radioiodine ablation treatment on PTC is routinely performed. However, many patients do not benefit from radioiodine therapy. Therefore, novel targeted therapies to suppress tumor growth and improve radioiodine uptake are required. La ribonucleoprotein domain family member (LARP)7 is a member of the LARP family and functions as a potential suppressor of the progression of carcinoma...
April 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29617798/inpatient-burden-of-esophageal-cancer-and-analysis-of-factors-affecting-in-hospital-mortality-and-length-of-stay
#2
S Sarvepalli, S K Garg, S S Sarvepalli, M P Parikh, V Wadhwa, S Jang, P N Thota, M R Sanaka
Esophageal cancer (EC) continues to be a major source of morbidity and mortality in the United States. However, there has been a relative dearth of research into hospital utilization in patients with EC. This study examines temporal trends in hospital admissions, length of stay (LOS), mortality, and costs associated with EC. In addition, we also analyzed factors associated with inpatient mortality and LOS. We interrogated National Inpatient Sample (NIS), a large registry of inpatient data, to retrieve information about various demographic and factors associated with hospital stay in patients who were admitted for EC between the years 1998 and 2013 in the United States...
March 28, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29608157/radionuclide-fluorescence-reporter-gene-imaging-to-track-tumor-progression-in-rodent-tumor-models
#3
Alessia Volpe, Francis Man, Lindsay Lim, Alex Khoshnevisan, Julia Blower, Philip J Blower, Gilbert O Fruhwirth
Metastasis is responsible for most cancer deaths. Despite extensive research, the mechanistic understanding of the complex processes governing metastasis remains incomplete. In vivo models are paramount for metastasis research, but require refinement. Tracking spontaneous metastasis by non-invasive in vivo imaging is now possible, but remains challenging as it requires long-time observation and high sensitivity. We describe a longitudinal combined radionuclide and fluorescence whole-body in vivo imaging approach for tracking tumor progression and spontaneous metastasis...
March 13, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29582961/-case-of-sialadenitis-by-iodinated-contrast-medium-in-a-dialysis-patient
#4
Mariadelina Simeoni, Rosalba Di Vilio, Giuseppe Leonardi, Silvia Bologna, Antonello Cardone, Annamaria Cerantonio, Domenico Sculco, Giuseppe Chiarella, Giorgio Fuiano
Background: Sialadenitis by iodinated contrast medium (i.c.m) oriodine mumps (IM) is a rare and late benign manifestation that occurs independently of intravenous or endoarterial administration modality. If renal function is normal, i.c.m. does not reach salivary glands concentrations able to induce sialadenitis. However, a critical glomerular filtration reduction may lead to salivary ducts edema and glandular swelling after i.c.m. injection. We report a rare case report of IM in a patient on chronic hemodialysis...
March 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29561759/epigenetic-modifications-in-thyroid-cancer-cells-restore-nis-and-radio-iodine-uptake-and-promote-cell-death
#5
Sabine Wächter, Alexander I Damanakis, Moritz Elxnat, Silvia Roth, Annette Wunderlich, Frederik A Verburg, Sebastian A Fellinger, Detlef K Bartsch, Pietro Di Fazio
Epigenetic modifications have been identified as being responsible for the de-differentiation of thyroid tissue and its malignant transformation. Cell proliferation inhibitory effects of the pan-deacetylase inhibitors panobinostat, SAHA and Trichostatin A (TSA), the modulation of the sodium iodide symporter (NIS; SLC5A5), thyroid transcription factor 1 (TTF1), high mobility group A2 (HMGA2), and H19 and their putative targeting miRNAs have been evaluated in vitro. The cell viability was measured in five thyroid cancer cell lines (FTC133, TPC1, BCPAP, 8505C, C643) by real time cell analyzer xCELLigence...
March 21, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29556926/nutrition-impact-symptoms-and-associated-outcomes-in-post-chemoradiotherapy-head-and-neck-cancer-survivors-a-systematic-review
#6
REVIEW
Sylvia L Crowder, Katherine G Douglas, M Yanina Pepino, Kalika P Sarma, Anna E Arthur
PURPOSE: It is estimated that more than 90% of head and neck cancer (HNC) survivors who underwent chemoradiotherapy experience one or more nutrition impact symptoms (NIS) in the months or years thereafter. Despite the high prevalence, there is limited research addressing long-term impact of NIS on outcomes such as nutrition and quality of life in HNC survivors treated with chemoradiotherapy. IMPLICATIONS FOR CANCER SURVIVORS: The prevalence and consequences of nutrition impact symptoms are substantial among head and neck cancer survivors beyond the acute phase of cancer treatment...
March 20, 2018: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29533097/head-and-neck-cancer-patients-do-not-meet-recommended-intakes-of-micronutrients-without-consuming-fortified-products
#7
Sara Nejatinamini, Catherine Kubrak, Mirey Álvarez-Camacho, Vickie E Baracos, Sunita Ghosh, Wendy V Wismer, Vera C Mazurak
This study assessed dietary and micronutrient intakes of head and neck cancer (HNC) patients at key points in the disease trajectory and evaluated the contribution of oral nutritional supplements (ONS) to micronutrient intake. HNC patients (n = 114) completed a three-day dietary record and a tool to assess Nutrition Impact Scores (NIS) at baseline, post-treatment, and follow-up. Foods were classified into food categories. Micronutrient, protein, and energy intakes were compared to European Society for Parenteral and Enteral Nutrition guidelines for cancer patients...
March 13, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29496566/effects-of-repeated-potassium-iodide-administration-on-genes-involved-in-synthesis-and-secretion-of-thyroid-hormone-in-adult-male-rat
#8
Dalila Lebsir, Line Manens, Stephane Grison, Philippe Lestaevel, Teni Ebrahimian, David Suhard, Guillaume Phan, Isabelle Dublineau, Karine Tack, Marc Benderitter, Annick Pech, Jean-Rene Jourdain, Maâmar Souidi
BACKGROUND: A single dose of potassium iodide (KI) is recommended to reduce the risk of thyroid cancer during nuclear accidents. However in case of prolonged radioiodine exposure, more than one dose of KI may be necessary. This work aims to evaluate the potential toxic effect of repeated administration of KI. METHODS: Adult Wistar rats received an optimal dose of KI 1 mg/kg over a period of 1, 4 or 8 days. RESULTS: hormonal status (TSH, FT4) of treated rats was unaffected...
February 26, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29495389/the-rs2910164-genetic-variant-of-mir-146a-3p-is-associated-with-increased-overall-mortality-in-patients-with-follicular-variant-papillary-thyroid-carcinoma
#9
Marta Kotlarek, Anna Kubiak, Małgorzata Czetwertyńska, Michał Świerniak, Wojciech Gierlikowski, Monika Kolanowska, Elwira Bakuła-Zalewska, Sissy M Jhiang, Krystian Jażdżewski, Anna Wójcicka
Aberrant expression of the sodium-iodide symporter (NIS) and the resistance to post-operative radioactive iodide treatment is a crucial cause of higher mortality of some thyroid cancer patients. In this study, we analyzed the impact of miR-146a on the expression and function of NIS and on the overall survival of thyroid cancer patients. The study included 2441 patients (2163 women; 278 men); including 359 cases with follicular variant of papillary thyroid carcinoma (fvPTC). miR: NIS interactions were analyzed in cell lines using in vivo binding and inhibition assays and radioactive iodine uptake assays...
February 26, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29468604/urinary-diversion-after-radical-cystectomy-for-bladder-cancer-comparing-trends-in-the-us-and-germany-from-2006-to-2014
#10
Christer Groeben, Rainer Koch, Martin Baunacke, Marianne Schmid, Angelika Borkowetz, Manfred P Wirth, Johannes Huber
OBJECTIVE: Our aim was to assess and compare trends of urinary diversion (UD) for patients receiving radical cystectomy for the treatment of bladder cancer in the US and Germany, and to investigate decisive predictors for the choice of UD. METHODS: We analyzed the nationwide German hospital billing database and the Nationwide Inpatient Sample (NIS) from 2006 to 2014. Cases with a bladder cancer diagnosis combined with RC were included, and trends in the choice of UD, transfusion rates, length of stay, and mortality were assessed...
February 21, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29467951/reverting-iodine-avidity-of-radioactive-iodine-refractory-thyroid-cancer-with-a-new-tyrosine-kinase-inhibitor-k905-0266-excavated-by-high-throughput-nis-sodium-iodide-symporter-enhancer-screening-platform-using-dual-reporter-gene-system
#11
Ji Min Oh, Senthilkumar Kalimuthu, Prakash Gangadaran, Se Hwan Baek, Liya Zhu, Ho Won Lee, Ramya Lakshmi Rajendran, Chae Moon Hong, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
Radioactive-iodine (RAI) therapy is typically unprevailing as anaplastic thyroid cancer (ATC) management, owing to the decrease in the endogenous sodium iodide symporter (NIS) expression. Therefore, new strategies for NIS re-induction are required to improve the efficacy of RAI therapy in ATC. In this study, we developed a novel high-throughput NIS enhancer screening platform using a dual reporter gene system to identify a potent tyrosine kinase inhibitor (TKI) and selected a new hit compound, K905-0266 TKI...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29437784/role-of-iodide-metabolism-in-physiology-and-cancer
#12
REVIEW
Antonio De la Vieja, Pilar Santisteban
Iodide (I- ) metabolism is crucial for the synthesis of thyroid hormones (THs) in the thyroid and the subsequent action of these hormones in the organism. I- is principally transported by the sodium iodide symporter (NIS) and by the anion exchanger PENDRIN, and recent studies have demonstrated the direct participation of new transporters including anoctamin 1 (ANO1), cystic fibrosis transmembrane conductance regulator (CFTR) and sodium multivitamin transporter (SMVT). Several of these transporters have been found expressed in various tissues, implicating them in I- recycling...
April 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29414821/procedures-performed-during-hospitalizations-for-malignant-pleural-effusions-data-from-the-2012-national-inpatient-sample
#13
Marc Fortin, Niloofar Taghizadeh, Alain Tremblay
BACKGROUND: Malignant pleural effusions (MPE) are a common clinical problem. Little is known about the burden of MPE and of the treatments used to alleviate its symptoms on the United States Health Care System. OBJECTIVES: We aimed to obtain a better portrait of inpatient pleural procedures performed in the United States. METHODS: We conducted a retrospective analysis of MPE-associated hospitalizations using the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample, Agency for Healthcare Research and Quality (HCUP-NIS 2012)...
February 7, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29403169/role-of-nuclear-morphometry-in-breast-cancer-and-its-correlation-with-cytomorphological-grading-of-breast-cancer-a-study-of-64-cases
#14
Anamika Kashyap, Manjula Jain, Shailaja Shukla, Manoj Andley
Background: Fine needle aspiration cytology (FNAC) is a simple, rapid, inexpensive, and reliable method of diagnosis of breast mass. Cytoprognostic grading in breast cancers is important to identify high-grade tumors. Computer-assisted image morphometric analysis has been developed to quantitate as well as standardize various grading systems. Aims: To apply nuclear morphometry on cytological aspirates of breast cancer and evaluate its correlation with cytomorphological grading with derivation of suitable cutoff values between various grades...
January 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29360785/exploring-facilitators-and-barriers-to-initiation-and-completion-of-the-human-papillomavirus-hpv-vaccine-series-among-parents-of-girls-in-a-safety-net-system
#15
Sean T O'Leary, Steven Lockhart, Juliana Barnard, Anna Furniss, Miriam Dickinson, Amanda F Dempsey, Shannon Stokley, Steven Federico, Michael Bronsert, Allison Kempe
Objective: To assess, among parents of predominantly minority, low-income adolescent girls who had either not initiated (NI) or not completed (NC) the HPV vaccine series, attitudes and other factors important in promoting the series, and whether attitudes differed by language preference. Design/Methods: From August 2013-October 2013, we conducted a mail survey among parents of girls aged 12-15 years randomly selected from administrative data in a Denver safety net system; 400 parents from each group (NI and NC) were targeted...
January 23, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29344184/therapeutic-effects-of-adenovirus-mediated-cd-and-nis-expression-combined-with-na131i-5-fc-on-human-thyroid-cancer
#16
Meng-Hui Yuan, Long-Xiao Wei, Run-Suo Zhou, Hai-Feng Xu, Jun-Yan Wang, Qian-Rong Bai
Thyroid cancer is the most common type of malignant endocrine tumor diagnosed. Previous studies have indicated that gene therapy is the most promising and effective therapeutic method for thyroid cancer. Therefore, in the present study, Na131I/5-fluorocytosine (5-FC) treatment was combined with cytosine deaminase (CD, encoded by the CDA gene) and sodium iodide symporter (NIS, encoded by the SLC5A5 gene) to act together as a therapeutic tool for thyroid cancer. The present study explored the combined cytotoxic effects of adenovirus-mediated CD and NIS under the control of the progression elevated gene-3 (PEG-3) promoter (Ad-PEG-3-CD-NIS) with Na131I/5-FC against the human thyroid cancer TT cell line in vitro...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29325434/collection-of-real-world-data-on-nivolumab-s-effectiveness-in-renal-cell-carcinoma-rationale-for-an-observational-study
#17
Jens Bedke, Marc-Oliver Grimm, Viktor Grünwald
Renal cell carcinoma (RCC) represents the seventh (men) respectively tenth (women) most frequent cancer in western countries. After one or more lines of VEGF-targeted therapy, immunotherapy with nivolumab is strongly recommended in patients with metastatic RCC. Nivolumab is the first, and so far, only approved programmed death 1 (PD-1) immune checkpoint inhibitor to demonstrate a gain in overall survival in RCC. We describe herein design and rationale of trial CA209653 ('NIS NORA'), a prospective, noninterventional cohort study investigating the effectiveness of nivolumab...
January 12, 2018: Future Oncology
https://www.readbyqxmd.com/read/29299444/temporal-trends-and-outcomes-of-acute-myocardial-infarction-in-patients-with-cancer
#18
Naga Venkata Pothineni, Nishi N Shah, Yogita Rochlani, Marwan Saad, Swathi Kovelamudi, Konstantinos Marmagkiolis, Sabha Bhatti, Mehmet Cilingiroglu, Wilbert S Aronow, Abdul Hakeem
Background: Data on outcomes of ST-elevation myocardial infarction (STEMI) in patients with cancer are scarce. We investigated the nationwide trends in admissions for STEMI, utilization of percutaneous coronary intervention (PCI), and in-hospital outcomes in patients with the three most common cancer diagnoses (lung, breast, and colon) compared to patients without cancer. Methods: We conducted an administrative database study using the Nationwide Inpatient Sample (NIS)...
December 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29298843/nis-expression-in-thyroid-tumors-relation-with-prognosis-clinicopathological-and-molecular-features
#19
Catarina Tavares, Maria João Coelho, Catarina Eloy, Miguel Melo, Adriana Gaspar da Rocha, Ana Pestana, Rui Batista, Luciana Bueno Ferreira, Elisabete Rios, Samia Selmi-Ruby, Bruno Cavadas, Luísa Pereira, Manuel Sobrinho Simões, Paula Soares
Thyroid cancer therapy is based on surgery followed by radioiodine treatment. The incorporation of radioiodine by cancer cells is mediated by sodium iodide symporter (NIS) (codified by the SLC5A5 gene), that is functional only when targeted to the cell membrane. We aimed to evaluate if NIS expression in thyroid primary tumors would be helpful in predicting tumor behavior, response to therapy and prognosis. NIS expression was addressed by qPCR and immunohistochemistry. In order to validate our data, we also studied SLC5A5 expression on 378 primary papillary thyroid carcinomas from The Cancer Genome Atlas (TCGA) database...
January 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29280482/national-trends-in-primary-tracheoesophageal-puncture-after-total-laryngectomy
#20
Rosh K V Sethi, Daniel G Deschler
OBJECTIVES/HYPOTHESIS: Tracheoesophageal puncture (TEP) can be performed at the time of laryngectomy (primary) or postoperatively (secondary). Prior studies demonstrate safe and earlier voice acquisition and rehabilitation with primary TEP. The objectives of this study were to assess national trends in primary TEP and identify factors associated with its use. STUDY DESIGN: Retrospective review. METHODS: Retrospective analysis of the Nationwide Inpatient Sample (NIS) from 2010 to 2014 was performed...
December 27, 2017: Laryngoscope
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