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https://www.readbyqxmd.com/read/28423515/preclinical-therapeutic-efficacy-of-a-novel-blood-brain-barrier-penetrant-dual-pi3k-mtor-inhibitor-with-preferential-response-in-pi3k-pten-mutant-glioma
#1
Dimpy Koul, Shuzhen Wang, Shaofang Wu, Norihiko Saito, Siyuan Zheng, Feng Gao, Isha Kaul, Masaki Setoguchi, Kiyoshi Nakayama, Kumiko Koyama, Yoshinobu Shiose, Erik P Sulman, Yasuhide Hirota, W K Alfred Yung
Glioblastoma (GBM) is an ideal candidate disease for signal transduction targeted therapy because the majority of these tumors harbor genetic alterations that result in aberrant activation of growth factor signaling pathways. Loss of heterozygosity of chromosome 10, mutations in the tumor suppressor gene PTEN, and PI3K mutations are molecular hallmarks of GBM and indicate poor prognostic outcomes in many cancers. Consequently, inhibiting the PI3K pathway may provide therapeutic benefit in these cancers. PI3K inhibitors generally block proliferation rather than induce apoptosis...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422601/degradation-of-resin-restorative-materials-by-streptococcus-mutans-a-pilot-study
#2
Ankit K Gautam, Ruchi Thakur, N D Shashikiran, Singla Shilpy, Nikita Agarwal, Shilpi Tiwari
OBJECTIVE: To evaluate the degradation of three resin based restorative materials by S Mutans. STUDY DESIGN: Class I cavity was prepared in extracted premolars and were randomly divided into 3 groups (Group I - Conventional composite (CC), Group II - Resin Modified GIC and Group III-Giomer). Teeth were then restored by respective restorative material and equally divided in two subgroups (Control and Experimental). Experiment subgroup samples were then incubated in 2 ml of BHI with 1:10 dilution of SM (MTCC-497) grown overnight in BHI whereas control subgroup samples were incubated in BHI without SM...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28420882/the-role-of-the-swi-snf-chromatin-remodeling-complex-in-maintaining-the-stemness-of-glioma-initiating-cells
#3
Hiroaki Hiramatsu, Kazuyoshi Kobayashi, Kyousuke Kobayashi, Takeshi Haraguchi, Yasushi Ino, Tomoki Todo, Hideo Iba
Glioma initiating cells (GICs) are thought to contribute to therapeutic resistance and tumor recurrence in glioblastoma, a lethal primary brain tumor in adults. Although the stem-like properties of GICs, such as self-renewal and tumorigenicity, are epigenetically regulated, the role of a major chromatin remodeling complex in human, the SWI/SNF complex, remains unknown in these cells. We here demonstrate that the SWI/SNF core complex, that is associated with a unique corepressor complex through the d4-family proteins, DPF1 or DPF3a, plays essential roles in stemness maintenance in GICs...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28418244/applying-bayesian-approach-to-combinatorial-problem-in-chemistry
#4
Yasuharu Okamoto
A Bayesian optimization procedure, in combination with density functional theory calculations, was applied to a combinatorial problem in chemistry. As a specific example, we examined the stable structures of lithium-graphite intercalation compounds (Li-GICs). We found that this approach efficiently identified the stable structure of stage-I and -II Li-GICs by calculating 4 - 6% of the full search space. We expect that the approach will be helpful in solving problems in chemistry that can be regarded as a kind of combinatorial problem...
April 18, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28403365/crown-discoloration-promoted-by-materials-used-in-regenerative-endodontic-procedures-and-effect-of-dental-bleaching-spectrophotometric-analysis
#5
Luciane Geanini Pena Dos Santos, Wilson Tadeu Felippe, Beatriz Dulcineia Mendes de Souza, Andrea Cristina Konrath, Mabel Mariela Rodríguez Cordeiro, Mara Cristina Santos Felippe
Objectives: To assess tooth crown's color after intracanal treatment with triple antibiotic paste (TAP) or calcium hydroxide (CH); cervical sealing with glass ionomer cement (GIC) or mineral trioxide aggregate (MTA); and bleaching with carbamide peroxide. Material and Methods: After pulp removal and color spectrophotometer measurement, 50 bovine incisors were divided into 4 experimental groups and one control (untreated). Experiments were performed in phases (Ph)...
March 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28403358/enhanced-bioactive-properties-of-biodentinetm-modified-with-bioactive-glass-nanoparticles
#6
Camila Corral Nuñez, Cristian Covarrubias, Eduardo Fernandez, Osmir Batista de Oliveira
Objective: To prepare nanocomposite cements based on the incorporation of bioactive glass nanoparticles (nBGs) into BiodentineTM (BD, Septodent, Saint-Maur-des-Fosses Cedex, France) and to assess their bioactive properties. Material and Methods: nBGs were synthesised by the sol-gel method. BD nanocomposites (nBG/BD) were prepared with 1 and 2% nBGs by weight; unmodified BD and GC Fuji IX (GIC, GC Corporation, Tokyo, Japan) were used as references. The in vitro ability of the materials to induce apatite formation was assessed in SBF by X-ray diffraction (XRD), attenuated total reflectance with Fourier transform infrared spectroscopy (ATR-FTIR), and scanning electron microscopy (SEM) with energy dispersive X-ray (EDX) analysis...
March 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28402940/prognostic-role-of-micrornas-in-human-gastrointestinal-cancer-a-systematic-review-and-meta-analysis
#7
REVIEW
Qiang Zheng, Changyu Chen, Haiyang Guan, Weibiao Kang, Changjun Yu
BACKGROUND: Gastrointestinal cancers (GICs) mainly including esophageal, gastric and colorectal cancer, are the most common cause of cancer-related death and lead into high mortality worldwide. We performed this systematic review and meta-analysis to elucidate relationship between multiple microRNAs (miRs) expression and survival of GIC patients. METHODS: We searched a wide range of database. Fixed-effects and random-effects models were used to calculate the pooled hazard ratio values of overall survival and disease free survival...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28380416/actin-cytoskeleton-regulator-arp2-3-complex-is-required-for-dll1-activating-notch1-signaling-to-maintain-the-stem-cell-phenotype-of-glioma-initiating-cells
#8
Chen Zhang, Long Hai, Meng Zhu, Shengping Yu, Tao Li, Yu Lin, Bo Liu, Xingchen Zhou, Lei Chen, Pengfei Zhao, Hua Zhou, Yubao Huang, Kai Zhang, Bingcheng Ren, Xuejun Yang
Glioblastoma (GBM) is the most common and lethal primary intracranial tumor. Actin cytoskeleton regulator Arp2/3 complex stimulates glioma cell motility and migration, and thus triggers tumor invasion. However, little is known regarding the role of actin cytoskeleton in maintaining the stem cell phenotype. Here, we showed that Arp2/3 complex improved stem cell phenotype maintenance through sustaining the activated Notch signaling. ShRNA targeting Notch ligand Delta-like 1 (DLL1) decreased CD133 and Nestin expression, and impaired the self-renewal ability of CD133+ U87-MG and U251-MG glioma cells, indicating DLL1/Notch1 signaling promoted stem cell phenotype maintenance...
March 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28372034/molecular-identification-enzyme-assay-and-metabolic-profiling-of-trichoderma-spp
#9
Soo-Jung Bae, Young-Hwan Park, Hyeun-Jong Bae, Junhyun Jeon, Hanhong Bae
The goal of this study was to identify and characterize the selected Trichoderma isolates by metabolic profiling and enzyme assay for evaluation of their potential as biocontrol agents against plant pathogens. Trichoderma isolates were obtained from the Rural Development Administration (RDA) Genebank Information Center (GIC) (Wanju, Republic of Korea). Eleven Trichoderma isolates were re-identified using ribosomal DNA internal transcribed spacer (ITS) regions. ITS sequence results showed new identification of Trichoderma isolates...
April 3, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28361871/a-tipping-point-in-refreezing-accelerates-mass-loss-of-greenland-s-glaciers-and-ice-caps
#10
B Noël, W J van de Berg, S Lhermitte, B Wouters, H Machguth, I Howat, M Citterio, G Moholdt, J T M Lenaerts, M R van den Broeke
Melting of the Greenland ice sheet (GrIS) and its peripheral glaciers and ice caps (GICs) contributes about 43% to contemporary sea level rise. While patterns of GrIS mass loss are well studied, the spatial and temporal evolution of GICs mass loss and the acting processes have remained unclear. Here we use a novel, 1 km surface mass balance product, evaluated against in situ and remote sensing data, to identify 1997 (±5 years) as a tipping point for GICs mass balance. That year marks the onset of a rapid deterioration in the capacity of the GICs firn to refreeze meltwater...
March 31, 2017: Nature Communications
https://www.readbyqxmd.com/read/28338314/surface-layer-evolution-on-graphite-during-electrochemical-sodium-tetraglyme-co-intercalation
#11
Julia Maibach, Fabian Jeschull, Daniel Brandell, Kristina Edström, Mario Valvo
One obstacle in sodium ion batteries is the lack of suitable anode materials. As recently shown, the most common anode material of the state of the art lithium ion batteries, graphite, can be used for sodium ion storage as well, if ether-based electrolyte solvents are used. These solvents cointercalate with the sodium ions leading to the highly reversible formation of ternary graphite intercalation compounds (t-GIC). In order for the solvent cointercalation to work efficiently, it is expected that only a very thin surface layer forms during electrochemical cycling...
April 3, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28327378/gender-related-psychopathology-in-opioid-use-disorder-results-from-a-representative-sample-of-italian-addiction-services
#12
Beniamino Leone, Marco Di Nicola, Lorenzo Moccia, Mauro Pettorruso, Luisa De Risio, Giuseppe Nucara, Lorenzo Zamboni, Antonino Callea, Luigi Janiri, Mauro Cibin, Fabio Lugoboni
AIMS: Gender and psychiatric comorbidity seem to influence patients' inter-individual response to Opioid Substitution Treatments (OST) in Opioid Use Disorder (OUD) management. The aim of the study was to assess psychopathological dimensions in an Italian sample of OUD individuals entering a methadone/buprenorphine maintenance program; secondary, we evaluated the possible gender-specific differences within the psychopathological profiles. METHODS: In a cross-sectional study, we recruited 1052 (792 male; 260 female) OUD subjects receiving OST...
March 10, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28326699/-influence-of-surface-roughness-on-oral-streptococcal-adhesion-forces-to-dental-filling-materials
#13
Zheng Sainan, Jiang Li, Zhang Lei, Hao Liying, Ye Lu, Li Wei
OBJECTIVE: This study is to determine the common oral streptococcal adhesion forces by using composite resin and glass ionomer cement (GIC) with different degrees of surface roughness via atomic force microscopy (AFM) analysis. The influence of surface roughness on bacterial adhesion force is also discussed. METHODS: Polishing and grinding were applied to obtain 300, 200, 100, and 10 nm surfaces of light-cured composite resin and GIC samples. Surface topography was assessed by AFM analysis...
October 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28322052/unifying-principles-on-the-reductive-covalent-graphene-functionalization
#14
Gonzalo Abellán, Milan Schirowski, Konstantin F Edelthalhammer, Michael Fickert, Katharina Werbach, Herwig Peterlik, Frank Hauke, Andreas Hirsch
Covalently functionalized graphene derivatives were synthesized via benchmark reductive routes using graphite intercalation compounds (GICs), in particular KC8. We have compared the graphene arylation and -alkylation of the GIC using 4-tert-butylphenyldiazonium- and bis-(4-(tert-butyl)phenyl)-iodonium salts as well as phenyl iodide, n-hexyl- and n-dodecyl iodide as electrophiles in model reactions. We have put a particular focus on the evaluation of the degree of addition and the bulk functional-ization homogeneity Hbulk...
March 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28301982/effects-of-glass-ionomer-cement-on-facial-nerve-a-clinical-and-histopathologic-evaluation
#15
Rauf Oguzhan Kum, Sezer Kulacoglu
OBJECTIVE: The aim of this study was to investigate the clinical and histopathologic effects of glass ionomer cement (GIC) on facial nerve. METHODS: Eight Wistar albino rats were included in the study. Under general anesthesia, bilateral facial nerves of rats were dissected. Saline was injected into right facial nerves, while GIC was dropped on left facial nerves. Facial nerve functions of the rats were evaluated using mustache and bling reflex scores everyday along 14 days...
March 16, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28301009/survival-and-factors-associated-with-failure-of-pulpectomies-performed-in-primary-teeth-by-dental-students
#16
Juliane Priscila Brustolin, Adriela Azevedo Souza Mariath, Thiago Machado Ardenghi, Luciano Casagrande
Although endodontic treatment is widely recommended for compromised dental pulp, there is no information regarding the factors associated with failures in primary teeth. The aim of this study was to evaluate the survival and factors associated with failure of pulpectomies performed in primary teeth by dental students. The sample comprised patients treated at a University Dental Service and required endodontic treatment in primary teeth. The study investigated treatment-related variables and patient factors potentially associated with treatment failure...
January 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/28280384/tapentadol-extended-release-for-the-management-of-chronic-neck-pain
#17
Domenico Billeci, Flaminia Coluzzi
BACKGROUND: The role of opioids in the management of chronic neck pain is still poorly investigated. No data are available on tapentadol extended release (ER). In this article, we present 54 patients with moderate-to-severe chronic neck pain treated with tapentadol ER. PATIENTS AND METHODS: Patients received tapentadol ER 100 mg/day; dosage was then adjusted according to clinical needs. The following parameters were recorded: pain; Douleur Neuropathique 4 score; Neck Disability Index score; range of motion; pain-associated sleep interference; quality of life (Short Form [36] Health Survey); Patient Global Impression of Change (PGIC); Clinician GIC; opioid-related adverse effects; and need for other analgesics...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28275275/in-vitro-study-on-temperature-changes-in-the-pulp-chamber-due-to-thermo-cure-glass-ionomer-cements
#18
Raimond Nb van Duinen, Saroash Shahid, Robert Hill, Domagoj Glavina
The application of the Glass Ionomer Cements in clinical dentistry is recommended due to properties such as fluoride release, chemical adhesion to tooth, negligible setting shrinkage, and coefficient of thermal expansion close to tooth, low creep, and good color stability. However, the cement is vulnerable to early exposure to moisture due to slow setting characteristics. The uses of external energy such as ultrasound and radiant heat (Thermo-curing) have been reported to provide acceleration of the setting chemistry and enhance physical properties...
December 2016: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/28270890/an-elevated-hba1c-level-is-associated-with-short-term-adverse-outcomes-in-patients-with-gastrointestinal-cancer-and-type-2-diabetes-mellitus
#19
Yingchun Huang, Huazhen Zheng, Peicong Chen, Jin Yang, Shaomin Lin, Tingting Liu, Shanwei Chen, Siqiang Lu, Junlian Chen, Wenpu Chen, Nanhai Peng
BACKGROUND: Although an elevated hemoglobin A1c (HbAc1) level is an independent predictor of worse survival in patients with both digestive cancer and diabetes mellitus, its relationship to short-term prognosis in these patients has not been addressed. This study assessed this relationship in gastrointestinal cancer (GIC) patients with type 2 diabetes mellitus (T2DM). METHODS: A retrospective review of patients with GIC with or without T2DM from 2004 to 2014 was performed...
April 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28263549/highly-efficient-high-pressure-homogenization-approach-for-scalable-production-of-high-quality-graphene-sheets-and-sandwich-structured-%C3%AE-fe2o3-graphene-hybrids-for-high-performance-lithium-ion-batteries
#20
Xin Qi, Hao-Bin Zhang, Jiantie Xu, Xinyu Wu, Dongzhi Yang, Jin Qu, Zhong-Zhen Yu
A highly efficient and continuous high-pressure homogenization (HPH) approach is developed for scalable production of graphene sheets and sandwich-structured α-Fe2O3/graphene hybrids by liquid-phase exfoliation of stage-1 FeCl3-based graphite intercalation compounds (GICs). The enlarged interlayer spacing of FeCl3-GICs facilitates their efficient exfoliation to produce high-quality graphene sheets. Moreover, sandwich-structured α-Fe2O3/few-layer graphene (FLG) hybrids are readily fabricated by thermally annealing the FeCl3 intercalated FLG sheets...
March 29, 2017: ACS Applied Materials & Interfaces
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