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https://www.readbyqxmd.com/read/29238047/negative-control-of-the-hgf-c-met-pathway-by-tgf-%C3%AE-a-new-look-at-the-regulation-of-stemness-in-glioblastoma
#1
Eleanna Papa, Michael Weller, Tobias Weiss, Elisa Ventura, Isabel Burghardt, Emese Szabó
Multiple target inhibition has gained considerable interest in combating drug resistance in glioblastoma, however, understanding the molecular mechanisms of crosstalk between signaling pathways and predicting responses of cancer cells to targeted interventions has remained challenging. Despite the significant role attributed to transforming growth factor (TGF)-β family and hepatocyte growth factor (HGF)/c-MET signaling in glioblastoma pathogenesis, their functional interactions have not been well characterized...
December 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29230257/nanotribological-properties-of-graphite-intercalation-compounds-afm-studies
#2
Zhiwei Chen, Dan Guo, Lina Si, Guoxin Xie
Tetraalkylammonium salts have larger ions than metal ions, which can greatly change the interlayer space and energy, and then potentially tune the properties of graphite. In this work, various graphite intercalation compounds (GICs) have been synthesized by intercalating tetraoctylammonium bromide (TOAB) ions into graphite through electrochemical interactions under different reduction potentials. Different degrees of expansion between graphite layers as well as their corresponding structures and topographies have been characterized by different analytical techniques...
2017: Scanning
https://www.readbyqxmd.com/read/29216968/gender-trouble-the-world-health-organization-the-international-statistical-classification-of-diseases-and-related-health-problems-icd-11-and-the-trans-kids
#3
Sam Winter
The World Health Organization (WHO) is revising its diagnostic manual, the International Statistical Classification of Diseases and Related Health Problems (ICD). At the time of writing, and based on recommendations from its ICD Working Group on Sexual Disorders and Sexual Health, WHO is proposing a new ICD chapter titled Conditions Related to Sexual Health, and that the gender incongruence diagnoses (replacements for the gender identity disorder diagnoses used in ICD-10) should be placed in that chapter. WHO is proposing that there should be a Gender incongruence of childhood (GIC) diagnosis for children below the age of puberty...
October 2017: Sexual Health
https://www.readbyqxmd.com/read/29208791/effect-of-temperature-on-film-thickness-of-two-types-of-commonly-used-luting-cements
#4
M Praveen Kumar, Reddy Priyadarshini, Yasangi M Kumar, K Shanthi Priya, Chunchuvyshnavi Chunchuvyshnavi, Harika Yerrapragada
AIM: The aim of this study is to evaluate the effect of temperature change on film thickness of both types of cements. MATERIALS AND METHODS: Totally, 60 samples were prepared with 10 in each subgroup, thus comprising 30 in each group. Materials tested were glass ionomer cement (GIC) type I and zinc phosphate type I. Samples were manipulated with manufacturer's instructions and tested according to American Dental Association (ADA) guidelines. RESULTS: The mean values of film thickness were recorded for both groups I and II...
December 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29207837/fracture-resistance-of-endodontically-treated-teeth-restored-with-biodentine-resin-modified-gic-and-hybrid-composite-resin-as-a-core-material
#5
Dayalan Subash, Krishnamma Shoba, Shibu Aman, Srinivasan Kumar Indu Bharkavi, Vijayan Nimmi, Radhakrishnan Abhilash
Introduction: The restoration of a severely damaged tooth usually needs a post and core as a part of treatment procedure to provide a corono - radicular stabilization. Biodentine is a class of dental material which possess high mechanical properties with excellent biocompatibility and bioactive behaviour. The sealing ability coupled with optimum physical properties could make Biodentine an excellent option as a core material. Aim: The aim of the study was to determine the fracture resistance of Biodentine as a core material in comparison with resin modified glass ionomer and composite resin...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29205613/survival-of-extensive-restorations-in-primary-molars-15-year-practice-based-study
#6
Battsetseg Tseveenjav, Jussi Furuholm, Aida Mulic, Håkon Valen, Tuomo Maisala, Seppo Turunen, Sinikka Varsio, Merja Auero, Leo Tjäderhane
BACKGROUND: Caries decline in the western world is accompanied by strong polarization among children; 8% of Finnish 5-year-olds having 76% of untreated caries. This high caries risk group needs preventive and restorative strategies. AIM: To explore survival of extensive restorations in primary molars. DESIGN: This study was based on health records from 2002 to 2016 of children under 18 years. RESULTS: Of severely affected primary molars (n = 1061), 41% were restored with preformed metal crowns (PMCs), 38% with glass-ionomer cement (GIC)/polyacid-modified resin composite (PAMRC)/resin-modified GIC (RMGIC), and 21% with resin composites (RC)...
December 3, 2017: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/29197139/the-impact-of-silver-nanoparticles-integration-on-biofilm-formation-and-mechanical-properties-of-glass-ionomer-cement
#7
Noha A El-Wassefy, Rasha H El-Mahdy, Naglaa R El-Kholany
OBJECTIVES: To study the effect of silver nanoparticles incorporation to glass ionomer cement (GIC) on the Staphylococcus aureus biofilm in terms of bacterial growth and evaluate the incorporating effect on hardness and compressive strength. METHODS: Silver nanopowder was added in concentration 0, 1, 3, and 5 wt% to the conventional powder of GIC Fuji IX GP and then the powder is added to the liquid and mixed together with the recommended Powder/liquid ratio of 3...
December 2, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/29195286/combining-extrapolation-with-ghost-interaction-correction-in-range-separated-ensemble-density-functional-theory-for-excited-states
#8
Md Mehboob Alam, Killian Deur, Stefan Knecht, Emmanuel Fromager
The extrapolation technique of Savin [J. Chem. Phys. 140, 18A509 (2014)], which was initially applied to range-separated ground-state-density-functional Hamiltonians, is adapted in this work to ghost-interaction-corrected (GIC) range-separated ensemble density-functional theory (eDFT) for excited states. While standard extrapolations rely on energies that decay as μ-2 in the large range-separation-parameter μ limit, we show analytically that (approximate) range-separated GIC ensemble energies converge more rapidly (as μ-3) towards their pure wavefunction theory values (μ → +∞ limit), thus requiring a different extrapolation correction...
November 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29194799/hyperstage-graphite-electrochemical-synthesis-and-spontaneous-reactive-exfoliation
#9
Intak Jeon, Bora Yoon, Maggie He, Timothy M Swager
Covalent modification of the π-electron basal planes of graphene enables the formation of new materials with enhanced functionality. An electrochemical method is reported for the formation of what is referred to as a Hyperstage-1 graphite intercalation compound (GIC), which has a very large interlayer spacing d001 > 15.3 Å and contains disordered interstitial molecules/ions. This material is highly activated and undergoes spontaneous exfoliation when reacted with diazonium ions to produce soluble graphenes with high functionalization densities of one pendant aromatic ring for every 12 graphene carbons...
December 1, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29190831/erectile-dysfunction-and-quality-of-life-in-men-receiving-methadone-or-buprenorphine-maintenance-treatment-a-cross-sectional-multicentre-study
#10
Fabio Lugoboni, Lorenzo Zamboni, Angela Federico, Stefano Tamburin
BACKGROUND: Erectile dysfunction (ED) is common among men on opioid replacement therapy (ORT), but most previous studies exploring its prevalence and determinants yielded contrasting findings. Moreover, the impact of ED on patients' quality of life (QoL) has been seldom explored. OBJECTIVE: To explore the prevalence and determinants of ED in men on ORT, and the impact on QoL. METHODS: In a multicentre cross-sectional study, we recruited 797 consecutive male patients on methadone and buprenorphine treatment, collected data on demographic, clinical, and psychopathological factors, and explored their role as predictors of ED and QoL through univariate and multivariate analysis...
2017: PloS One
https://www.readbyqxmd.com/read/29190533/evaluating-the-critical-strain-energy-release-rate-of-bioactive-glass-coatings-on-ti6al4v-substrates-after-degradation
#11
A Matinmanesh, Y Li, A Nouhi, P Zalzal, E H Schemitsch, M R Towler, M Papini
It has been reported that the adhesion of bioactive glass coatings to Ti6Al4V reduces after degradation, however, this effect has not been quantified. This paper uses bilayer double cantilever (DCB) specimens to determine GIC and GIIC, the critical mode I and mode II strain energy release rates, respectively, of bioactive coating/Ti6Al4V substrate systems degraded to different extents. Three borate-based bioactive glass coatings with increasing amounts of incorporated SrO (0, 15 and 25mol%) were enamelled onto Ti6Al4V substrates and then immersed in de-ionized water for 2, 6 and 24h...
November 10, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29179503/can-polysaccharide-k-improve-therapeutic-efficacy-and-safety-in-gastrointestinal-cancer-a-systematic-review-and-network-meta-analysis
#12
Yan Ma, Xiaofen Wu, Jingwen Yu, Jinyan Zhu, Xia Pen, Xianjun Meng
Objective: To assess the comparative efficacy and safety of polysaccharide K (PSK), with or without chemotherapy, for patients with gastrointestinal cancer (GIC) through a systematic review and network meta-analysis. Materials and Methods: We performed a network meta-analysis to identify evidence from randomized controlled trials. We searched PubMed, Embase and the Cochrane Library for publications up to May 2017. The prespecified primary efficacy outcomes were 1-7 year overall survival (OS), while the secondary efficacy outcomes were 1-7 year disease-free survival (DFS); we performed subgroup analyses and meta-regressions according to the cancer type (colorectal, esophagus and gastric cancer) and treatment arms (with or without chemotherapy)...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29175161/induction-of-dna-double-strand-breaks-in-human-gingival-fibroblasts-by-eluates-from-titanium-dioxide-modified-glass-ionomer-cements
#13
Arunee Laiteerapong, Franz-Xaver Reichl, Yang Yang, Reinhard Hickel, Christof HÖgg
OBJECTIVES: (1) To investigate the genotoxicity of a glass ionomer cement (GIC) and GIC incorporated with titanium dioxide nanopoarticle (TiO2NPs) and with microparticle (TiO2MPs) on DNA double-strand breaks of human gingival fibroblast cells (HGFs). (2) To compare the genotoxic differences between GIC and two modified cements. METHODS: TiO2NPsGIC and TiO2MPsGIC were prepared by adding 10% w/w of TiO2NPs and TiO2MPs to the GIC powder and hand-mixed followed the manufacturer instruction...
November 23, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29128128/cad-fe-modeling-and-analysis-of-class-ii-restorations-incorporating-resin-composite-glass-ionomer-and-glass-ceramic-materials
#14
Pietro Ausiello, Stefano Ciaramella, Massimo Martorelli, Antonio Lanzotti, Antonio Gloria, David C Watts
OBJECTIVES: To investigate the influence of specific resin-composite, glass ceramic and glass ionomer cement (GIC) material combinations in a "multi-layer" technique to replace enamel and dentin in class II mesio-occlusal-distal (MOD) dental restorations using 3D-Finite Element Analysis (FEA). METHODS: Four 3D-FE models (A-D) of teeth, adhesively restored with different filling materials, were created and analyzed in comparison with a 3D model (E) of a sound lower molar...
November 8, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29122072/inhibition-of-residual-cariogenic-bacteria-in-atraumatic-restorative-treatment-by-chlorhexidine-disinfection-or-incorporation
#15
Jooie S Joshi, Noor M Roshan, Basha Sakeenabi, P Poornima, N B Nagaveni, V V Subbareddy
PURPOSE: The purpose of this study was to compare the efficacy of chlorhexidine (CHX) cavity disinfection and of CHX containing glass ionomer cement (GIC) in inhibiting residual cariogenic bacteria. METHODS: Ninety, five- to nine-year-olds were randomly allocated to three groups: Group 1-CHX containing GIC; Group 2-CHX cavity disinfection; and Group 3-conventional GIC. Total viable count (TVC), Streptococcus mutans (SM), and Lactobacillus (LB) were analyzed pre-, post-, and three months after atraumatic restorative treatment (ART)...
July 15, 2017: Pediatric Dentistry
https://www.readbyqxmd.com/read/29109749/push-out-bond-strength-of-different-intracanal-posts-in-the-anterior-primary-teeth-according-to-root-canal-filling-materials
#16
Nilgoon Pasdar, Bahman Seraj, Mostafa Fatemi, Shirin Taravati
Background: This study was carried out to evaluate the effect of root canal filling on the bond strength of three intracanal posts in the primary incisors. Materials and Methods: Sixty primary incisors were prepared and then divided into two groups (n = 30). The first group canals obturated with zinc oxide eugenol (ZOE) and Group 2 canals obturated with Metapex. Further, the two group categories were divided into three subgroups (n = 10): (1) short composite post (SCP), (2) glass fiber posts (GFPs) cemented with flowable composite, and (3) GFP with glass ionomer cement (GFP + GIC)...
September 2017: Dental Research Journal
https://www.readbyqxmd.com/read/29109747/effect-of-finishing-polishing-techniques-and-time-on-surface-roughness-of-esthetic-restorative-materials
#17
Prashanthi Sampath Madhyastha, Shreya Hegde, N Srikant, Ravindra Kotian, Srividhya Sriraman Iyer
Background: Surface roughness associated with improper finishing/polishing of restorations can result in plaque accumulation, gingival irritation, surface staining, and poor esthetic of restored teeth. The study aimed to evaluate the efficiency of various finishing and polishing systems and time using various procedures on surface roughness of some esthetic restorative materials. Materials and Methods: In this in vitro study, samples of two composite materials, compomer and glass ionomer cement (GIC) materials, were fabricated...
September 2017: Dental Research Journal
https://www.readbyqxmd.com/read/29103516/1-3%C3%AE-glucan-anchored-paclitaxel-loaded-chitosan-nanocarrier-endows-enhanced-hemocompatibility-with-efficient-anti-glioblastoma-stem-cells-therapy
#18
Pankaj K Singh, Anup K Srivastava, Atul Dev, Babita Kaundal, Subhasree Roy Choudhury, Surajit Karmakar
Recurrence of glioblastoma is one of the major concerns due to its heterogeneous nature and association of Glioma Initiating stem-like Cells (GICs). Nanoparticles mediated delivery of chemotherapeutic agent targeting both cancer and glioma stem cells could provide a solution to recurrent malignancies of the glioblastoma tumor. The approach described here provides enhanced chemotherapeutic potency utilizing 1,3β-Glucan as an outer shell to the chitosan nanoparticles (Cs-NPs) loaded with paclitaxel to prevent hemolysis with, the core-shell nano-structure (Cs-PTX-NP) enabling effective chemotherapy against malignant glioblastoma...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29101399/enhanced-arctic-amplification-began-at-the-mid-brunhes-event-400-000-years-ago
#19
T M Cronin, G S Dwyer, E K Caverly, J Farmer, L H DeNinno, J Rodriguez-Lazaro, L Gemery
Arctic Ocean temperatures influence ecosystems, sea ice, species diversity, biogeochemical cycling, seafloor methane stability, deep-sea circulation, and CO2 cycling. Today's Arctic Ocean and surrounding regions are undergoing climatic changes often attributed to "Arctic amplification" - that is, amplified warming in Arctic regions due to sea-ice loss and other processes, relative to global mean temperature. However, the long-term evolution of Arctic amplification is poorly constrained due to lack of continuous sediment proxy records of Arctic Ocean temperature, sea ice cover and circulation...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29090921/two-step-electrochemical-intercalation-and-oxidation-of-graphite-for-the-mass-production-of-graphene-oxide
#20
Jianyun Cao, Pei He, Mahdi A Mohammed, Xin Zhao, Robert J Young, Brian Derby, Ian A Kinloch, Robert A W Dryfe
Conventional chemical oxidation routes for the production of graphene oxide (GO), such as the Hummers method, suffer from environmental and safety issues due to their use of hazardous and explosive chemicals. These issues are addressed by electrochemical oxidation methods but such approaches typically have a low yield due to inhomogeneous oxidation. Herein we report a two-step electrochemical intercalation and oxidation approach to produce GO on a large laboratory scale (ten's of grams) comprising: (1) forming a stage 1 graphite intercalation compound (GIC) in concentrated sulfuric acid; (2) oxidizing and exfoliating the stage 1 GIC in an aqueous solution of 0...
November 1, 2017: Journal of the American Chemical Society
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