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https://www.readbyqxmd.com/read/28511515/comparative-evaluation-of-antibacterial-and-adhesive-properties-of-chitosan-modified-glass-ionomer-cement-and-conventional-glass-ionomer-cement-an-in-vitro-study
#1
Arpan Debnath, Srivastava Bagepalli Kesavappa, Gyanendra Pratap Singh, Shruthi Eshwar, Vipin Jain, Madhuniranjan Swamy, Punith Shetty
INTRODUCTION: Recent studies have reported the incorporation of modifiers with conventional Glass Ionomer Cement (GIC) to enhance its antibacterial effect. One such modification being the addition of Chitosan (CH). However, these modifiers might affect the physical properties of the restorations. AIM: The aim of the present study was to investigate the effect of modifying the liquid phase of conventional GIC with 10% v/v CH on the antibacterial properties and adhesion to enamel in comparison to conventional GIC...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28493832/apobec3g-acts-as-a-therapeutic-target-in-mesenchymal-gliomas-by-sensitizing-cells-to-radiation-induced-cell-death
#2
Yu Wang, Shaofang Wu, Siyuan Zheng, Shuzhen Wang, Arjun Wali, Ravesanker Ezhilarasan, Erik P Sulman, Dimpy Koul, W K Alfred Yung
Genomic, transcriptional, and proteomic analyses of brain tumors reveal that subtypes differ in their pathway activity, progression, and response to therapy. We performed an expression profiling of Glioma Initiating Cells (GICs) and comparative analysis between different groups of GICs indicates major variations in gene expression. Hierarchical clustering analysis revealed groups of GICs reflecting their heterogeneity, and among some of the genes as major regulators of mesenchymal phenotype, we identified ABOBEC3G as one of the most discriminating genes in mesenchymal group...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28492746/biocompatibility-of-a-new-dental-glass-ionomer-cement-with-cellulose-microfibers-and-cellulose-nanocrystals
#3
Rafael Menezes-Silva, Fabiano Vargas Pereira, Maria Helena Santos, Janir Alves Soares, Suelleng Maria Cunha Santos Soares, João Luiz de Miranda
Developing new restorative materials should avoid damage to tissue structures. This study evaluated the biocompatibility of a commercial dental glass ionomer cement (GIC) mechanically reinforced with cellulose microfibers (GIC+CM) or cellulose nanocrystals (GIC+CN) by implantation of three test specimens in subcutaneous tissue in the dorsal region of 15 Rattus norvegicus albinus rats. Each rat received one specimen of each cement, resulting in the following groups (n=15): Group GIC (Control), Group GIC+CM and Group GIC+NC...
March 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/28492197/the-effect-of-atraumatic-restorative-treatment-on-adhesive-restorations-for-dental-caries-in-deciduous-molars
#4
Eliane Batista de Medeiros Serpa, Marayza Alves Clementino, Ana Flávia Granville-Garcia, Aronita Rosenblatt
BACKGROUND: Minimal invasive approaches to managing caries, such as partial caries removal techniques and atraumatic restorative treatment (ART), are showing increasing evidence of improved outcomes over the conventional complete caries removal. OBJECTIVE: To evaluate clinically and radiographically the effect of ART on restorations using restorative cement and glass ionomer cement (GIC) for dental caries in the deciduous molars of children aged between 4 and 8 years...
April 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28486630/paired-related-homeobox-1-transactivates-dopamine-d2-receptor-to-maintain-propagation-and-tumorigenicity-of-glioma-initiating-cells
#5
Yamu Li, Wen Wang, Fangyu Wang, Qiushuang Wu, Wei Li, Xiaoling Zhong, Kuan Tian, Tao Zeng, Liang Gao, Ying Liu, Shu Li, Xiaobing Jiang, Guangwei Du, Yan Zhou
Glioblastoma multiforme (GBM) is a highly invasive brain tumor with limited therapeutic means and poor prognosis. Recent studies indicate that glioma-initiating cells/glioma stem cells (GICs/GSCs) may be responsible for tumor initiation, infiltration, and recurrence. GICs could aberrantly employ molecular machinery balancing self-renewal and differentiation of embryonic neural precursors. Here, we find that paired related homeobox 1 (PRRX1), a homeodomain transcription factor that was previously reported to control skeletal development, is expressed in cortical neural progenitors and is required for their self-renewal and proper differentiation...
May 9, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/28484053/cutting-edge-erk1-mediates-the-autocrine-positive-feedback-loop-of-tgf-%C3%AE-and-furin-in-glioma-initiating-cells
#6
Elisa Ventura, Michael Weller, Isabel Burghardt
Glioblastoma is the most common and aggressive intrinsic brain tumor in adults. Self-renewing, highly tumorigenic glioma-initiating cells (GIC) have been linked to glioma invasive properties, immunomodulation, and increased angiogenesis, leading to resistance to therapy. TGF-β signaling has been associated with the tumorigenic activity of GIC. TGF-β is synthesized as a precursor molecule and proteolytically processed to the mature form by members of the family of the proprotein convertases subtilisin/kexin...
May 8, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28476709/spectrophotometric-assessment-of-different-surface-coating-materials-on-conventional-glass-ionomer-cement
#7
Aftab Ahmed Khan, Adel Zia Siddiqui, Jamaluddin Syed, Shafaq Noori, Abdulaziz Abdullah Alkheraif
The purpose of this in vitro study was to analyse the absorbance of dye material in conventional glass ionomer cement (GIC) by applying various commercially available surface protecting layers on GIC. 90 disc-shaped specimens were made using brass mold measuring 7mm in diameter and 2mm in thickness. 30 specimens were selected for each week testing having 6 groups (n=5). The groups were: G1 (Control group), G2 (Nail polish coated GIC), G3 (Master bond coated GIC), G4 (Copal varnish coated GIC), G5 (Varnal coated GIC), G6 (Cold mold seal coated GIC)...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28473157/co-occurring-attention-deficit-hyperactivity-disorder-symptoms-in-adults-affected-by-heroin-dependence-patients-characteristics-and-treatment-needs
#8
Fabio Lugoboni, Frances Rudnick Levin, Maria Chiara Pieri, Matteo Manfredini, Lorenzo Zamboni, Lorenzo Somaini, Gilberto Gerra, Gruppo InterSert Collaborazione Scientifica Gics
Attention Deficit Hyperactivity Disorder (ADHD) is a risk for substance use disorders. The aim of this study was to investigate the association between adult ADHD symptoms, opioid use disorder, life dysfunction and co-occurring psychiatric symptoms. 1057 heroin dependent patients on opioid substitution treatment participated in the survey. All patients were screened for adult ADHD symptoms using the Adult ADHD Self-Report Scale (ASRS-v1.1). 19.4% of the patients screened positive for concurrent adult ADHD symptoms status and heroin dependence...
April 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28470622/green-synthesis-and-characterization-of-ag-nanoparticles-from-mangifera-indica-leaves-for-dental-restoration-and-antibacterial-applications
#9
Dola Sundeep, T Vijaya Kumar, P S Subba Rao, R V S S N Ravikumar, A Gopala Krishna
Green synthesis has gained a wide recognition as clean synthesis technique in the recent years. In the present investigation, silver nanoparticles were prepared by a novel green synthesis technique using Mangifera indica (Mango leaves) and found to be successfully used in dental applications. The prepared samples were spectroscopically characterized by XRD, PSA, SEM with EDS, and UV-Vis spectroscopy. The crystalline size and lattice strain were analyzed from the XRD data which were counter-verified by W-H plots and particle size analyzer...
May 3, 2017: Progress in biomaterials
https://www.readbyqxmd.com/read/28465066/bacterial-adhesion-not-inhibited-by-ion-releasing-bioactive-glass-filler
#10
Kumiko Yoshihara, Noriyuki Nagaoka, Yukinori Maruo, Hidehiko Sano, Yasuhiro Yoshida, Bart Van Meerbeek
OBJECTIVE: Bioactive glasses and surface pre-reacted glass-ionomer (sPRG) filler possess cariostatic properties owing to ion release. Many studies investigated potential cariostatic effects; few studies evaluated the surface stability and the structural changes their surfaces undergo in acidic conditions. METHODS: The surface resistance against acid attack and the surface receptiveness for bacterial adhesion and biofilm formation of a sPRG-filled (Beautifil ll, Shofu) and conventional glass-filled (Herculite XRV Ultra, Kerr) resin-based composite (RBC), and a conventional glass-ionomer cement (GIC; Fuji IX GP Extra, GC) were examined...
April 29, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28459464/bone-morphogenetic-protein-signaling-mediated-by-alk-2-and-dlx2-regulates-apoptosis-in-glioma-initiating-cells
#11
E Raja, A Komuro, R Tanabe, S Sakai, Y Ino, N Saito, T Todo, M Morikawa, H Aburatani, D Koinuma, C Iwata, K Miyazono
Bone morphogenetic protein (BMP) signaling exerts antitumor activities in glioblastoma; however, its precise mechanisms remain to be elucidated. Here, we demonstrated that the BMP type I receptor ALK-2 (encoded by the ACVR1 gene) has crucial roles in apoptosis induction of patient-derived glioma-initiating cells (GICs), TGS-01 and TGS-04. We also characterized a BMP target gene, Distal-less homeobox 2 (DLX2), and found that DLX2 promoted apoptosis and neural differentiation of GICs. The tumor-suppressive effects of ALK-2 and DLX2 were further confirmed in a mouse orthotopic transplantation model...
May 1, 2017: Oncogene
https://www.readbyqxmd.com/read/28439458/the-genomic-sequence-of-exiguobacterium-chiriqhucha-str-n139-reveals-a-species-that-thrives-in-cold-waters-and-extreme-environmental-conditions
#12
Ana Gutiérrez-Preciado, Carlos Vargas-Chávez, Mariana Reyes-Prieto, Omar F Ordoñez, Diego Santos-García, Tania Rosas-Pérez, Jorge Valdivia-Anistro, Eria A Rebollar, Andrés Saralegui, Andrés Moya, Enrique Merino, María Eugenia Farías, Amparo Latorre, Valeria Souza
We report the genome sequence of Exiguobacterium chiriqhucha str. N139, isolated from a high-altitude Andean lake. Comparative genomic analyses of the Exiguobacterium genomes available suggest that our strain belongs to the same species as the previously reported E. pavilionensis str. RW-2 and Exiguobacterium str. GIC 31. We describe this species and propose the chiriqhucha name to group them. 'Chiri qhucha' in Quechua means 'cold lake', which is a common origin of these three cosmopolitan Exiguobacteria. The 2,952,588-bp E...
2017: PeerJ
https://www.readbyqxmd.com/read/28423515/preclinical-therapeutic-efficacy-of-a-novel-blood-brain-barrier-penetrant-dual-pi3k-mtor-inhibitor-with-preferential-response-in-pi3k-pten-mutant-glioma
#13
Dimpy Koul, Shuzhen Wang, Shaofang Wu, Norihiko Saito, Siyuan Zheng, Feng Gao, Isha Kaul, Masaki Setoguchi, Kiyoshi Nakayama, Kumiko Koyama, Yoshinobu Shiose, Erik P Sulman, Yasuhide Hirota, W K Alfred Yung
Glioblastoma (GBM) is an ideal candidate disease for signal transduction targeted therapy because the majority of these tumors harbor genetic alterations that result in aberrant activation of growth factor signaling pathways. Loss of heterozygosity of chromosome 10, mutations in the tumor suppressor gene PTEN, and PI3K mutations are molecular hallmarks of GBM and indicate poor prognostic outcomes in many cancers. Consequently, inhibiting the PI3K pathway may provide therapeutic benefit in these cancers. PI3K inhibitors generally block proliferation rather than induce apoptosis...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422601/degradation-of-resin-restorative-materials-by-streptococcus-mutans-a-pilot-study
#14
Ankit K Gautam, Ruchi Thakur, N D Shashikiran, Singla Shilpy, Nikita Agarwal, Shilpi Tiwari
OBJECTIVE: To evaluate the degradation of three resin based restorative materials by S Mutans. STUDY DESIGN: Class I cavity was prepared in extracted premolars and were randomly divided into 3 groups (Group I - Conventional composite (CC), Group II - Resin Modified GIC and Group III-Giomer). Teeth were then restored by respective restorative material and equally divided in two subgroups (Control and Experimental). Experiment subgroup samples were then incubated in 2 ml of BHI with 1:10 dilution of SM (MTCC-497) grown overnight in BHI whereas control subgroup samples were incubated in BHI without SM...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28420882/the-role-of-the-swi-snf-chromatin-remodeling-complex-in-maintaining-the-stemness-of-glioma-initiating-cells
#15
Hiroaki Hiramatsu, Kazuyoshi Kobayashi, Kyousuke Kobayashi, Takeshi Haraguchi, Yasushi Ino, Tomoki Todo, Hideo Iba
Glioma initiating cells (GICs) are thought to contribute to therapeutic resistance and tumor recurrence in glioblastoma, a lethal primary brain tumor in adults. Although the stem-like properties of GICs, such as self-renewal and tumorigenicity, are epigenetically regulated, the role of a major chromatin remodeling complex in human, the SWI/SNF complex, remains unknown in these cells. We here demonstrate that the SWI/SNF core complex, that is associated with a unique corepressor complex through the d4-family proteins, DPF1 or DPF3a, plays essential roles in stemness maintenance in GICs...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28418244/applying-bayesian-approach-to-combinatorial-problem-in-chemistry
#16
Yasuharu Okamoto
A Bayesian optimization procedure, in combination with density functional theory calculations, was applied to a combinatorial problem in chemistry. As a specific example, we examined the stable structures of lithium-graphite intercalation compounds (Li-GICs). We found that this approach efficiently identified the stable structure of stage-I and -II Li-GICs by calculating 4-6% of the full search space. We expect that this approach will be helpful in solving problems in chemistry that can be regarded as a kind of combinatorial problem...
May 4, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28403365/crown-discoloration-promoted-by-materials-used-in-regenerative-endodontic-procedures-and-effect-of-dental-bleaching-spectrophotometric-analysis
#17
Luciane Geanini Pena Dos Santos, Wilson Tadeu Felippe, Beatriz Dulcineia Mendes de Souza, Andrea Cristina Konrath, Mabel Mariela Rodríguez Cordeiro, Mara Cristina Santos Felippe
Objectives: To assess tooth crown's color after intracanal treatment with triple antibiotic paste (TAP) or calcium hydroxide (CH); cervical sealing with glass ionomer cement (GIC) or mineral trioxide aggregate (MTA); and bleaching with carbamide peroxide. Material and Methods: After pulp removal and color spectrophotometer measurement, 50 bovine incisors were divided into 4 experimental groups and one control (untreated). Experiments were performed in phases (Ph)...
March 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28403358/enhanced-bioactive-properties-of-biodentinetm-modified-with-bioactive-glass-nanoparticles
#18
Camila Corral Nuñez, Cristian Covarrubias, Eduardo Fernandez, Osmir Batista de Oliveira
Objective: To prepare nanocomposite cements based on the incorporation of bioactive glass nanoparticles (nBGs) into BiodentineTM (BD, Septodent, Saint-Maur-des-Fosses Cedex, France) and to assess their bioactive properties. Material and Methods: nBGs were synthesised by the sol-gel method. BD nanocomposites (nBG/BD) were prepared with 1 and 2% nBGs by weight; unmodified BD and GC Fuji IX (GIC, GC Corporation, Tokyo, Japan) were used as references. The in vitro ability of the materials to induce apatite formation was assessed in SBF by X-ray diffraction (XRD), attenuated total reflectance with Fourier transform infrared spectroscopy (ATR-FTIR), and scanning electron microscopy (SEM) with energy dispersive X-ray (EDX) analysis...
March 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28402940/prognostic-role-of-micrornas-in-human-gastrointestinal-cancer-a-systematic-review-and-meta-analysis
#19
REVIEW
Qiang Zheng, Changyu Chen, Haiyang Guan, Weibiao Kang, Changjun Yu
BACKGROUND: Gastrointestinal cancers (GICs) mainly including esophageal, gastric and colorectal cancer, are the most common cause of cancer-related death and lead into high mortality worldwide. We performed this systematic review and meta-analysis to elucidate relationship between multiple microRNAs (miRs) expression and survival of GIC patients. METHODS: We searched a wide range of database. Fixed-effects and random-effects models were used to calculate the pooled hazard ratio values of overall survival and disease free survival...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28380416/actin-cytoskeleton-regulator-arp2-3-complex-is-required-for-dll1-activating-notch1-signaling-to-maintain-the-stem-cell-phenotype-of-glioma-initiating-cells
#20
Chen Zhang, Long Hai, Meng Zhu, Shengping Yu, Tao Li, Yu Lin, Bo Liu, Xingchen Zhou, Lei Chen, Pengfei Zhao, Hua Zhou, Yubao Huang, Kai Zhang, Bingcheng Ren, Xuejun Yang
Glioblastoma (GBM) is the most common and lethal primary intracranial tumor. Actin cytoskeleton regulator Arp2/3 complex stimulates glioma cell motility and migration, and thus triggers tumor invasion. However, little is known regarding the role of actin cytoskeleton in maintaining the stem cell phenotype. Here, we showed that Arp2/3 complex improved stem cell phenotype maintenance through sustaining the activated Notch signaling. ShRNA targeting Notch ligand Delta-like 1 (DLL1) decreased CD133 and Nestin expression, and impaired the self-renewal ability of CD133+ U87-MG and U251-MG glioma cells, indicating DLL1/Notch1 signaling promoted stem cell phenotype maintenance...
May 16, 2017: Oncotarget
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