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https://www.readbyqxmd.com/read/28642924/influence-of-niobium-pentoxide-addition-on-the-properties-of-glass-ionomer-cements
#1
Isadora Martini Garcia, Vicente Castelo Branco Leitune, Gabriela De Souza Balbinot, Susana Maria Werner Samuel, Fabrício Mezzomo Collares
Objective: To determine the influence of niobium pentoxide (Nb2O5) addition on the physical and chemical properties of glass ionomer cements (GICs). Materials and methods: Five, 10 or 20 wt.% of Nb2O5 were incorporated into commercial GICs (Maxxion R, Vitro Molar, Vitro Fil R) and one group of each GIC remained without Nb2O5 (control groups). The GICs were evaluated by Knoop hardness, compressive strength, acid erosion, particle size and radiopacity. Data were analyzed by two-way ANOVA followed by Tukey's test...
December 2016: Acta Biomaterialia Odontologica Scandinavica
https://www.readbyqxmd.com/read/28642913/the-effect-of-petroleum-jelly-light-cured-varnish-and-different-storage-media-on-the-flexural-strength-of-glass-ionomer-dental-cements
#2
Kristina Gorseta, Domagoj Glavina, Tomislav Skrinjaric, Beata Czarnecka, John W Nicholson
This study determined the influence of coating with either petroleum jelly or light-cured varnish and storage medium on the flexural strength of glass-ionomer cements (GIC). The flexural strength of two glass-ionomer cements (Fuji Equia Fil and Ketac Molar Aplicap) was measured. Specimens (2 × 2 × 25 mm) were prepared in three groups: uncoated, coated with petroleum jelly, or coated with light-cured varnish (EquiaCoat) cured for 20 s using a cure lamp (Bluephase G2, Ivoclar Vivadent, Schaan, Liechtenstein)...
December 2016: Acta Biomaterialia Odontologica Scandinavica
https://www.readbyqxmd.com/read/28641532/trimethylamine-n-oxide-tmao-as-a-new-potential-therapeutic-target-for-insulin-resistance-and-cancer
#3
Jens Oellgaard, Signe Abitz Winther, Tobias Schmidt Hansen, Peter Rossing, Bernt Johan von Scholten
BACKGROUND: The intake of animal products in food has been associated with both the development of insulin resistance and gastrointestinal cancers (GIC). Through the digestion of animal protein and other constituents of animal products, the commensal bacteria in the gut (the gut microbiota) forms metabolites that can contribute to the development of both insulin resistance and cancer. Trimethylamine-N-Oxide (TMAO) is such a molecule and has recently drawn a lot of attention as it may be a risk factor for - and a link between - the gut microbiota and cardiovascular and renal disease...
June 21, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28634226/phostine-pst3-1a-targets-mgat5-and-inhibits-glioblastoma-initiating-cell-invasiveness-and-proliferation
#4
Zahra Hassani, Ali Saleh, Soumaya Turpault, Salim Khiati, Willy Morelle, Jacques Vignon, Jean-Philippe Hugnot, Emmanuelle Uro-Coste, Philippe Legrand, Marcel Delaforge, Séverine Loiseau, Ludovic Clarion, Marc Lecouvey, Jean-Noël Volle, David Virieux, Jean-Luc Pirat, Hugues Duffau, Norbert Bakalara
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor and accounts for a significant proportion of all primary brain tumors. Median survival after treatment is around 15 months. Remodeling of N-glycans by the N-acetylglucosamine glycosyltransferase (MGAT5) regulates tumoral development. Here, perturbation of MGAT5 enzymatic activity by the small-molecule inhibitor 3-Hydroxy-4,5-bis-benzyloxy-6-benzyloxymethyl-2-phenyl2-oxo-2λ5-[1,2]oxaphosphinane (PST3.1a) restrains GBM growth. In cell based assays it is demonstrated that PST3...
June 20, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28625518/histone-chaperone-asf1a-predicts-poor-outcomes-for-patients-with-gastrointestinal-cancer-and-drives-cancer-progression-by-stimulating-transcription-of-%C3%AE-catenin-target-genes
#5
Xiuming Liang, Xiaotian Yuan, Jingya Yu, Yujiao Wu, Kailin Li, Chao Sun, Shuyan Li, Li Shen, Feng Kong, Jihui Jia, Magnus Björkholm, Dawei Xu
Epigenetic mechanisms play a key role in gastrointestinal cancer (GIC) development and progression, and most studies have been focused on aberrant DNA methylation and histone modifying enzymes. However, the histone H3-H4 chaperone ASF1A is an important factor regulating chromatin assembling and gene transcription, while it is currently unclear whether ASF1A is involved in cancer pathogenesis. The present study is thus designed to address this issue. Here we showed that ASF1A expression was widespread in GIC-derived cell lines and up-regulated in primary GIC...
June 8, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28621688/radioresistance-of-mesenchymal-glioblastoma-initiating-cells-correlates-with-patient-outcome-and-is-associated-with-activation-of-inflammatory-program
#6
Elisabetta Stanzani, Fina Martínez-Soler, Teresa Martín Mateos, Noemi Vidal, Alberto Villanueva, Miquel Angel Pujana, Jordi Serra-Musach, Núria de la Iglesia, Pepita Giménez-Bonafé, Avelina Tortosa
Glioblastoma (GBM) still remains an incurable disease being radiotherapy (RT) the mainstay treatment. Glioblastoma intra-tumoral heterogeneity and Glioblastoma-Initiating Cells (GICs) challenge the design of effective therapies. We investigated GICs and non-GICs response to RT in a paired in-vitro model and addressed molecular programs activated in GICs after RT. Established GICs heterogeneously expressed several GICs markers and displayed a mesenchymal signature. Upon fractionated RT, GICs reported higher radioresistance compared to non-GICs and showed lower α- and β-values, according to the Linear Quadratic Model interpretation of the survival curves...
June 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28611845/novel-nanotechnology-of-tio2-improves-physical-chemical-and-biological-properties-of-glass-ionomer-cement
#7
Daniela Dellosso Cibim, Miki Taketomi Saito, Priscila Alves Giovani, Ana Flávia Sanches Borges, Vanessa Gallego Arias Pecorari, Orisson Ponce Gomes, Paulo Noronha Lisboa-Filho, Francisco Humberto Nociti-Junior, Regina Maria Puppin-Rontani, Kamila Rosamilia Kantovitz
The aim of this study was to assess the performance of glass ionomer cement (GIC) added with TiO2 nanotubes. TiO2 nanotubes [3%, 5%, and 7% (w/w)] were incorporated into GIC's (Ketac Molar EasyMix™) powder component, whereas unblended powder was used as control. Physical-chemical-biological analysis included energy dispersive spectroscopy (EDS), surface roughness (SR), Knoop hardness (SH), fluoride-releasing analysis, cytotoxicity, cell morphology, and extracellular matrix (ECM) composition. Parametric or nonparametric ANOVA were used for statistical comparisons (α ≤ 0...
2017: International Journal of Biomaterials
https://www.readbyqxmd.com/read/28609494/effect-of-three-clinical-curing-treatments-on-fluoride-release-and-surface-hardness-of-glass-ionomer-cements
#8
Dimitrios Dionysopoulos, Kosmas Tolidis, Paris Gerasimou, Thrasyvoulos Sfeikos
The purpose of this study was to investigate the effect of radiant heat, ultrasonic treatment, and 42.7 wt% CaCl₂ solution on fluoride release and surface hardness in three conventional glass-ionomer cements (GICs). The fluoride release patterns of each GIC were evaluated during a 28-day period using a fluoride ion-selective electrode. The surface hardness of the tested GICs was evaluated 24 hours after preparation of the specimens using Vickers hardness test. Statistical analysis of the data was made using analysis of variance and Bonferroni post hoc test (α = ...
July 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28592117/mechanisms-regulating-radiosensitivity-of-glioma-stem-cells
#9
Y Liu, Y Shen, T Sun, W Yang
Malignant glioblastoma (GBM) has become a very common and difficult brain tumor given its low cure rate and high recurrence rate. GBMs are resistant to treatments because glioma stem cells (GSCs)/glioma-initiating cells (GICs), a specific subpopulation of GBM, possess properties of tumor stem cells, such as unlimited proficiency, self-renewal, differentiation and resistance to chemotherapy and radiotherapy, and exhibit a very strong DNA repair capability. Radiotherapy has become a preponderant treatment, and researchers have found many significant tumor microenvironmental factors and valuable signaling pathways regulating the GSC radioresistance, including NOTCH, Wnt/β-catenin, Hedgehog, STAT3, and PI3K/AKT/mTOR...
June 8, 2017: Neoplasma
https://www.readbyqxmd.com/read/28571830/effect-of-bulk-fill-base-material-on-fracture-strength-of-root-filled-teeth-restored-with-laminate-resin-composite-restorations
#10
N A Taha, G A Maghaireh, A S Ghannam, J E Palamara
OBJECTIVES: To evaluate the effect of using a bulk-fill flowable base material on fracture strength and fracture patterns of root-filled maxillary premolars with MOD preparations restored with laminate restorations. METHODS: Fifty extracted maxillary premolars were selected for the study. Standardized MOD cavities with endodontic treatment were prepared for all teeth, except for intact control. The teeth were divided randomly into five groups (n=10); (Group 1) sound teeth, (Group 2) unrestored teeth; (Group 3) MOD cavities with Vitrebond base and resin-based composite (Ceram...
May 29, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28571275/in-vitro-cytotoxicity-evaluation-of-novel-nano-hydroxyapatite-silica-incorporated-glass-ionomer-cement
#11
Tahir Yusuf Noorani, Norhayati Luddin, Ismail Ab Rahman, Saman Malik Masudi
INTRODUCTION: Glass Ionomer Cements (GIC) are among the most popular restorative materials, but their use in dentistry is limited due to their physical properties. The hardness of GIC was improved by incorporation of nano-hydroxyapatite-silica into GIC, to expand its applicability. AIM: To evaluate the cytotoxic effects of nano-hydroxyapatite-silica incorporated glass ionomer cement (HA-SiO2-GIC) on human Dental Pulp Stem Cells (DPSC) and compare it with conventional GIC and resin modified GIC...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28571260/anxiety-levels-among-five-year-old-children-undergoing-art-restoration-a-cross-sectional-study
#12
Ishan, K K Shivlingesh, Vartika Agarwal, Bhuvan Deep Gupta, Richa Anand, Abhinav Sharma, Sumedha Kushwaha, Khateeb Khan
INTRODUCTION: Atraumatic Restorative Treatment (ART) involves manually excavating the carious part of the tooth and restoring the prepared cavity with chemically adhesive restorative material [Glass Ionomer Cement (GIC)] and it may induce and/or impact the dental anxiety in children. It is well established that ART procedure is less anxiety producing when compared with other restorative procedures using dental drill. AIM: The aim of this study was to evaluate the anxiety levels among five-year-old children undergoing ART restoration in I...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28540486/the-expression-of-mcm7-is-a-useful-biomarker-in-the-early-diagnostic-of-gastric-cancer
#13
Jing-Yan Yang, Dong Li, Yuan Zhang, Bing-Xin Guan, Ping Gao, Xing-Chen Zhou, Cheng-Jun Zhou
The aim of this study was to investigate the expression of minichromosome maintenance complex component 7 (MCM7) in gastric mucosal lesions, further to find its potential effect as a biomarker to distinguish intraepithelial neoplasia from gastric mucosal lesions. MCM7 and Ki67 were detected in 93 cases of gastric mucosal lesions by immunohistochemistry. MCM7 and Ki67 expression in GT were lowest compared with other groups (P<0.001), meanwhile there were significant differences compared with Group IM and other groups in MCM7 and Ki67 expression (P<0...
May 25, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28536026/nanochitosan-modified-glass-ionomer-cement-with-enhanced-mechanical-properties-and-fluoride-release
#14
R Senthil Kumar, N Ravikumar, S Kavitha, S Mahalaxmi, R Jayasree, T S Sampath Kumar, M Haneesh
Conventional glass-ionomer cements (GIC) are one of the most prevalent dental restorative materials, but their use is limited by their relatively low mechanical strength. Efforts have been made to improve the mechanical properties by addition of various fillers of which nano-sized particles appears to be a promising strategy. In the current study, effect of addition of nanochitosan particles in GIC (NCH-GIC) on compressive strength, flexural strength, wear resistance and fluoride release has been evaluated and compared with conventional GIC (C-GIC)...
May 20, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28535954/sol-gel-derived-bioactive-glass-nanoparticle-incorporated-glass-ionomer-cement-with-or-without-chitosan-for-enhanced-mechanical-and-biomineralization-properties
#15
Dong-Ae Kim, Jung-Hwan Lee, Soo-Kyung Jun, Hae-Won Kim, Mohamed Eltohamy, Hae-Hyoung Lee
OBJECTIVE: This study investigated the mechanical and in vitro biological properties (in immortalized human dental pulp stem cells (ihDPSCs)) of bioactive glass nanoparticle (BGN)-incorporated glass ionomer cement (GIC) with or without chitosan as a binder. METHODS: After the BGNs were synthesized and characterized, three experimental GICs and a control (conventional GIC) that differed in the additive incorporated into a commercial GIC liquid (Hy-bond, Shofu, Japan) were produced: BG5 (5wt% of BGNs), CL0...
May 20, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28511515/comparative-evaluation-of-antibacterial-and-adhesive-properties-of-chitosan-modified-glass-ionomer-cement-and-conventional-glass-ionomer-cement-an-in-vitro-study
#16
Arpan Debnath, Srivastava Bagepalli Kesavappa, Gyanendra Pratap Singh, Shruthi Eshwar, Vipin Jain, Madhuniranjan Swamy, Punith Shetty
INTRODUCTION: Recent studies have reported the incorporation of modifiers with conventional Glass Ionomer Cement (GIC) to enhance its antibacterial effect. One such modification being the addition of Chitosan (CH). However, these modifiers might affect the physical properties of the restorations. AIM: The aim of the present study was to investigate the effect of modifying the liquid phase of conventional GIC with 10% v/v CH on the antibacterial properties and adhesion to enamel in comparison to conventional GIC...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28493832/apobec3g-acts-as-a-therapeutic-target-in-mesenchymal-gliomas-by-sensitizing-cells-to-radiation-induced-cell-death
#17
Yu Wang, Shaofang Wu, Siyuan Zheng, Shuzhen Wang, Arjun Wali, Ravesanker Ezhilarasan, Erik P Sulman, Dimpy Koul, W K Alfred Yung
Genomic, transcriptional, and proteomic analyses of brain tumors reveal that subtypes differ in their pathway activity, progression, and response to therapy. We performed an expression profiling of Glioma Initiating Cells (GICs) and comparative analysis between different groups of GICs indicates major variations in gene expression. Hierarchical clustering analysis revealed groups of GICs reflecting their heterogeneity, and among some of the genes as major regulators of mesenchymal phenotype, we identified ABOBEC3G as one of the most discriminating genes in mesenchymal group...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28492746/biocompatibility-of-a-new-dental-glass-ionomer-cement-with-cellulose-microfibers-and-cellulose-nanocrystals
#18
Rafael Menezes-Silva, Fabiano Vargas Pereira, Maria Helena Santos, Janir Alves Soares, Suelleng Maria Cunha Santos Soares, João Luiz de Miranda
Developing new restorative materials should avoid damage to tissue structures. This study evaluated the biocompatibility of a commercial dental glass ionomer cement (GIC) mechanically reinforced with cellulose microfibers (GIC+CM) or cellulose nanocrystals (GIC+CN) by implantation of three test specimens in subcutaneous tissue in the dorsal region of 15 Rattus norvegicus albinus rats. Each rat received one specimen of each cement, resulting in the following groups (n=15): Group GIC (Control), Group GIC+CM and Group GIC+NC...
March 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/28492197/the-effect-of-atraumatic-restorative-treatment-on-adhesive-restorations-for-dental-caries-in-deciduous-molars
#19
Eliane Batista de Medeiros Serpa, Marayza Alves Clementino, Ana Flávia Granville-Garcia, Aronita Rosenblatt
BACKGROUND: Minimal invasive approaches to managing caries, such as partial caries removal techniques and atraumatic restorative treatment (ART), are showing increasing evidence of improved outcomes over the conventional complete caries removal. OBJECTIVE: To evaluate clinically and radiographically the effect of ART on restorations using restorative cement and glass ionomer cement (GIC) for dental caries in the deciduous molars of children aged between 4 and 8 years...
April 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28486630/paired-related-homeobox-1-transactivates-dopamine-d2-receptor-to-maintain-propagation-and-tumorigenicity-of-glioma-initiating-cells
#20
Yamu Li, Wen Wang, Fangyu Wang, Qiushuang Wu, Wei Li, Xiaoling Zhong, Kuan Tian, Tao Zeng, Liang Gao, Ying Liu, Shu Li, Xiaobing Jiang, Guangwei Du, Yan Zhou
Glioblastoma multiforme (GBM) is a highly invasive brain tumor with limited therapeutic means and poor prognosis. Recent studies indicate that glioma-initiating cells/glioma stem cells (GICs/GSCs) may be responsible for tumor initiation, infiltration, and recurrence. GICs could aberrantly employ molecular machinery balancing self-renewal and differentiation of embryonic neural precursors. Here, we find that paired related homeobox 1 (PRRX1), a homeodomain transcription factor that was previously reported to control skeletal development, is expressed in cortical neural progenitors and is required for their self-renewal and proper differentiation...
May 9, 2017: Journal of Molecular Cell Biology
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