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https://www.readbyqxmd.com/read/29685176/atr-kinase-inhibitors-nvp-bez235-and-azd6738-effectively-penetrate-the-brain-after-systemic-administration
#1
Guido Fròsina, Aldo Profumo, Daniela Marubbi, Diana Marcello, Jean Louis Ravetti, Antonio Daga
Ataxia Telangiectasia and Rad3 related protein (ATR) is a central mediator of the response to DNA damage that may cause the quiescent resistance of cancer initiating cells to genotoxic radiotherapy. NVP-BEZ235 is a dual PI3K/mTOR inhibitor that also effectively targets ATR with IC50  = 21 × 10- 9  M in cells. AZD6738 does not target significantly PI3K/mTOR-related kinases but specifically inhibits ATR with IC50  = 74 × 10- 9  M in cells. Both drugs have been proposed as radiosensitizers of different tumors including glioblastoma (GB), the most malignant brain tumor...
April 23, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29678079/implementing-modular-research-consents-using-ihe-advanced-patient-privacy-consents
#2
Bjoern Schreiweis, Tobias Bronsch, Angela Merzweiler, Bjoern Bergh
The re-use of healthcare information for biomedical research is increasing and with it the importance of a consent management framework implementing computable consents. Based on requirements concerning a consent representation the Advanced Patient Privacy Consents (APPC) Profile of Integrating the Healthcare Enterprise (IHE) is evaluated and mapped to these requirements. As IHE APPC was developed for computable patient consents, the mapping of consents for research projects is possible by re-using the elements defined...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29674829/influence-of-ultrasonics-on-the-penetration-depth-of-ah-plus-acroseal-and-endorez-root-canal-sealers-an-in-vitro-study
#3
P Krishna Prasad, Abhishek Sankhala, Aastha Tiwari, Shrikant Parakh, Gagan R Madan, Ankita Singh
Aim: The aim of this study is to evaluate the effect of ultrasonic activation on the penetration depth of AH Plus, Acroseal, and EndoREZ sealers into dentinal tubules using Confocal laser microscopy. Methods: A total of 60 single-rooted teeth were prepared and divided into three groups on the basis of the type of sealer used (G1: AH Plus, G2: Acroseal and G3:EndoREZ). Each group was further subdivided into two equal subgroups on the basis of ultrasonic activation of sealers and nonactivation...
March 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29674824/effect-of-acid-etching-on-the-micro-shear-bond-strength-of-resin-composite-calcium-silicate-interface-evaluated-over-different-time-intervals-of-bond-aging
#4
Neha Sultana, Ruchika Roongta Nawal, Sarika Chaudhry, Malavika Sivakumar, Sangeeta Talwar
Introduction: With the introduction of calcium silicate materials, pulp capping procedure has been simplified due to their therapeutic pulp capping capabilities and ability to be used as a provisional bulk restorative material simultaneously. The quality of the adhesive bond between these cements and composite is of clinical significance with regard to the longevity of the final laminate restoration. Thus, this study aims to compare the in vitro microtensile bond strengths of resin composite to different calcium silicate cements versus glass ionomer cement (GIC)...
March 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29674812/effect-of-incorporation-of-zinc-oxide-nanoparticles-on-mechanical-properties-of-conventional-glass-ionomer-cements
#5
Narges Panahandeh, Hassan Torabzadeh, Mohammadamin Aghaee, Elham Hasani, Saeed Safa
Aim: The aim of this study is to investigate the physical properties of conventional and resin-modified glass ionomer cements (GICs) compared to GICs supplemented with zinc oxide (ZnO) nanofiller particles at 5% (w/w). Methods: In this in vitro study, ZnO nanoparticles of different morphologies (nanospherical, nanorod, and nanoflower) were incorporated to glass ionomer powder. The samples were subjected to the flexural strength ( n = 20) and surface hardness test ( n = 12) using a universal testing machine and a Vickers hardness machine, respectively...
March 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29673791/the-effects-of-polysaccharides-from-auricularia-auricula-huaier-in-adjuvant-anti-gastrointestinal-cancer-therapy-a-systematic-review-and-network-meta-analysis
#6
REVIEW
Yan Ma, Chen Wang, Qi Zhang, Xia Peng, Ying Feng, Xianjun Meng
The aim of this study was to assess the comparative efficacy and safety of polysaccharides from Auricularia auricula (Huaier) for patients with gastrointestinal cancers (GICs) through a systematic review and network meta-analysis. We performed a network meta-analysis to identify evidence from clinical trials. We searched databases for publications up to February 2018. The prespecified primary efficacy outcomes were clinical therapeutic effects, which included the treatment response rate, 0.5-year overall survival rate, 1-year overall survival rate, 2-year overall survival rate, KPS improved rate and AFP decreased rate...
April 16, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29658546/influence-of-molecular-weight-between-crosslinks-on-the-mechanical-properties-of-polymers-formed-via-ring-opening-metathesis
#7
Tyler R Long, Robert M Elder, Erich D Bain, Kevin A Masser, Timothy W Sirk, Jian H Yu, Daniel B Knorr, Joseph L Lenhart
The apparent molecular weight between crosslinks (Mc,a) in a polymer network plays a fundamental role in the network mechanical response. We systematically varied Mc,a independent of strong noncovalent bonding by using ring-opening metathesis polymerization (ROMP) to co-polymerize dicyclopentadiene (DCPD) with a chain extender that increases Mc,a or a di-functional crosslinker that decreases Mc,a. We compared the ROMP series quasi-static modulus (E), tensile yield stress (σy), and fracture toughness (KIC and GIC) in the glassy regime with literature data for more polar thermosets...
April 16, 2018: Soft Matter
https://www.readbyqxmd.com/read/29653140/in-vitro-mechanical-stimulation-facilitates-stress-dissipation-and-sealing-ability-at-the-conventional-glass-ionomer-cement-dentin-interface
#8
Manuel Toledano, Raquel Osorio, Estrella Osorio, Inmaculada Cabello, Manuel Toledano-Osorio, Fátima S Aguilera
OBJECTIVE: The aim of this study was to evaluate the induced changes in the chemical and mechanical performance at the glass-ionomer cement-dentin interface after mechanical load application. METHODS: A conventional glass-ionomer cement (GIC) (Ketac Bond), and a resin-modified glass-ionomer cement (RMGIC) (Vitrebond Plus) were used. Bonded interfaces were stored in simulated body fluid, and then tested or submitted to the mechanical loading challenge. Different loading waveforms were applied: No cycling, 24 h cycled in sine or loaded in sustained hold waveforms...
April 10, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29649506/clinical-performance-of-glass-ionomer-cement-and-composite-resin-in-class-ii-restorations-in-primary-teeth-a-systematic-review-and-meta-analysis
#9
REVIEW
Ana Giselle Aguiar Dias, Marcela Baraúna Magno, Alberto Carlos Botazzo Delbem, Robson Frederico Cunha, Lucianne Cople Maia, Juliano Pelim Pessan
OBJECTIVES: This study compared the clinical performance of glass ionomer cement (GIC) compared to composite resin (CR) in Class II restorations in primary teeth. DATA: Literature search according to PRISMA guidelines including randomized controlled trials comparing Class II restorations performed with GIC, compared to CR, in primary teeth. SOURCES: PubMeb, Scopus, Web of Science, VHL, Cochrane Library, Clinical Trials and OpenGrey, regardless of date or language...
April 9, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29628646/antibacterial-activity-of-dental-restorative-material-an-in-vitro-study
#10
Nishmitha N Hegde, Shruthi H Attavar, Mithra N Hegde, G Priya
Aim: The study evaluated the antibacterial effects of dental restorations such as nano-hybrid composite (Empress), a glass ionomer cement (GIC Gold label Type 9) and silver amalgam against Streptococcus mutans . Materials and Methods: A modified bacterial suspension within the material assay was used to study the antibacterial effects. A volume of 20 μl of bacterial suspensions were placed in a narrow conical cavity within the materials. They were incubated for 0, 3, 6, 12, 24, and 48 h at 37°C...
January 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29577946/specificity-of-spontaneous-eeg-associated-with-different-levels-of-cognitive-and-communicative-dysfunctions-in-children
#11
Nadezhda Ju Kozhushko, Zhanna V Nagornova, Sergey A Evdokimov, Natalia V Shemyakina, Valery A Ponomarev, Ekaterina P Tereshchenko, Jury D Kropotov
This study aimed to reveal electrophysiological markers of communicative and cognitive dysfunctions of different severity in children with autism spectrum disorder (ASD). Eyes-opened electroencephalograms (EEGs) of 42 children with ASD, divided into two groups according to the severity of their communicative and cognitive dysfunctions (24 with severe and 18 children with less severe ASD), and 70 age-matched controls aged 4-9 years were examined by means of spectral and group independent component (gIC) analyses...
March 22, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29567317/improvement-of-the-mechanical-tribological-and-antibacterial-properties-of-glass-ionomer-cements-by-fluorinated-graphene
#12
Li Sun, Zhuanjun Yan, Youxin Duan, Junyan Zhang, Bin Liu
OBJECTIVE: The aim of this study was to improve the mechanical properties, wear resistance and antibacterial properties of conventional glass ionomer cements (GICs) by fluorinated graphene (FG), under the premise of not influencing their solubility and fluoride ion releasing property. MATERIALS AND METHODS: FG with bright white color was prepared using graphene oxide by a hydrothermal reaction. Experimental modified GICs was prepared by adding FG to the traditional GICs powder with four different weight ratios (0...
March 19, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29563434/nanoclay-reinforced-glass-ionomer-cements-in-vitro-wear-evaluation-and-comparison-by-two-wear-test-methods
#13
Muhammad A Fareed, Artemis Stamboulis
Glass ionomer cement (GIC) represents a major transformation in restorative dentistry. Wear of dental restoratives is a common phenomenon and the determination of the wear resistance of direct-restorative materials is a challenging task. The aim of this paper was to evaluate the wear resistance of novel glass ionomer cement by two wear-test methods and to compare the two wear methods.The wear resistance of a conventional glass ionomer cement (HiFi Advanced Health Care Kent, UK) and cements modified by including various percentages of nanoclays (1, 2 and 4 wt %) was measured by a reciprocating wear test (ball-on-flat) and Oregon Health and Sciences University's (OHSU) wear simulator...
October 19, 2017: Dentistry journal
https://www.readbyqxmd.com/read/29553113/-oral-and-systemic-symptoms-in-children-with-fruit-allergy
#14
Taisuke Kato, Naoya Tajima, Katsumasa Kitamura, Yoshihiro Takasato, Iwao Tajima, Manabu Ono, Kazunori Tagami, Kazunori Sakai, Tomoko Furuta, Shiro Sugiura, Komei Ito
BACKGROUND AND PURPOSE: The principal aim of this study was to clarify the clinical profile of pediatric patients with fruit allergies. SUBJECTS AND METHODS: We assigned 265 pediatric patients with fruit allergies who were receiving outpatient treatment at Aichi Children's Health and Medical Center and 32 who underwent kiwi or banana oral food chal- lenge (OFC) test to an oral symptom group or a systemic symptom group and retrospectively examined their clinical profiles and prognosis from their medical records...
2018: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29524027/retention-rates-and-caries-preventive-effects-of-two-different-sealant-materials-a-randomised-clinical-trial
#15
Renata Nunes Cabral, Jorge Faber, Simone Auxiliadora Morais Otero, Leandro Augusto Hilgert, Soraya Coelho Leal
OBJECTIVES: The aim of this study was to compare the caries-preventive effect and the retention rates of sealants prepared with a new modified and a high-viscosity glass-ionomer cement (GIC) in recently erupted first permanent molars.  MATERIALS AND METHODS: Fifty-six children (224 teeth) were included in a split-mouth randomised clinical trial. All children had their four first permanent molars sealed with either Clinpro XT Varnish (CXT) or Fuji IX GP FAST (FJ). FJ sealants were placed according to the ART protocol...
March 9, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29504390/nanoscale-mobility-of-aqueous-polyacrylic-acid-in-dental-restorative-cements
#16
Marcella Cabrera Berg, Ana Raquel Benetti, Mark T F Telling, Tilo Seydel, Dehong Yu, Luke L Daemen, Heloisa N Bordallo
: Hydrogen dynamics in a time range from hundreds of femtoseconds (fs) to nanoseconds (ns) can be directly analyzed using neutron spectroscopy, where information on the inelastic and quasi-elastic scattering, hereafter INS and QENS, can be obtained. In this study, we applied these techniques to understand how the nanoscale mobility of the aqueous solution of polyacrylic acid (PAA) used in conventional Glass Ionomer Cements (GIC) changes under confinement. Combining the spectroscopic analysis with calorimetric results we were able to separate distinct motions within the liquid and in the GIC's...
March 5, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29480969/transcriptional-control-of-o-6-methylguanine-dna-methyltransferase-expression-and-temozolomide-resistance-in-glioblastoma
#17
Caroline Happold, Nina Stojcheva, Manuela Silginer, Tobias Weiss, Patrick Roth, Guido Reifenberger, Michael Weller
O6 -methylguanine DNA methyltransferase (MGMT) promoter methylation is a predictive biomarker for benefit from alkylating chemotherapy, specifically temozolomide (TMZ), in glioblastoma, the most common malignant intrinsic brain tumor. Glioma-initiating cells (GIC) with stem-like properties have been associated with resistance to therapy and progression. We assessed the levels of MGMT mRNA and MGMT protein by real-time PCR and immunoblot and evaluated the impact of MGMT on TMZ sensitivity in clonogenicity assays in GIC sphere cultures (S) or differentiated adherent monolayer cultures (M)...
February 26, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29440113/effect-of-a1c-and-glucose-on-postoperative-mortality-in-noncardiac-and-cardiac-surgeries
#18
Willem van den Boom, Rebecca A Schroeder, Michael W Manning, Tracy L Setji, Gic-Owens Fiestan, David B Dunson
OBJECTIVE: Hemoglobin A1c (A1C) is used in assessment of patients for elective surgeries because hyperglycemia increases risk of adverse events. However, the interplay of A1C, glucose, and surgical outcomes remains unclarified, with often only two of these three factors considered simultaneously. We assessed the association of preoperative A1C with perioperative glucose control and their relationship with 30-day mortality. RESEARCH DESIGN AND METHODS: Retrospective analysis on 431,480 surgeries within the Duke University Health System determined the association of preoperative A1C with perioperative glucose (averaged over the first 3 postoperative days) and 30-day mortality among 6,684 noncardiac and 6,393 cardiac surgeries with A1C and glucose measurements...
April 2018: Diabetes Care
https://www.readbyqxmd.com/read/29422475/clinical-evaluation-of-microhybrid-composite-and-glass-lonomer-restorative-material-in-permanent-teeth
#19
Khalil Kharma, Tatiana Zogheib, Shilpa Bhandi, Carina Mehanna
AIM: The aim of this study was to clinically compare glass ionomer cement (GIC) with microhybrid composite resin used in class I cavities on permanent teeth over a period of 9 months. MATERIALS AND METHODS: A total of 40 teeth with class I cavities were divided into two groups (n = 20) and restored with GIC (EQUIA; GC) and microhybrid resin composite (Amelogen Plus; Ultradent). Restorations were evaluated at ×4.5 magnification using the United States Public Health Service (USPHS) criteria every 3 months...
February 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29420559/effects-of-different-radio-opacifying-agents-on-physicochemical-and-biological-properties-of-a-novel-root-end-filling-material
#20
Yao-Zhong Chen, Xiao-Ying Lü, Gen-Di Liu
BACKGROUND/PURPOSE: Radio-opacity is an essential attribute of ideal root-end filling materials because it is important for clinicians to observe root canal filling and to facilitate the follow-up instructions. The novel root-end filling material (NRFM) has good cytocompatibility and physicochemical properties but low intrinsic radio-opacity value. To improve its radio-opacity value, three novel radio-opaque root-end filling materials (NRRFMs) were developed by adding barium sulphate (NRFM-Ba), bismuth trioxide (NRFM-Bi) and zirconium dioxide (NRFM-Zr) to NRFM, respectively...
2018: PloS One
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