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Anthony kim

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https://www.readbyqxmd.com/read/28921709/kidney-allograft-failure-in-the-steroid-free-immunosuppression-era-a-matched-case-control-study
#1
Mohamad M Alkadi, Jim Kim, Meredith J Aull, Joseph E Schwartz, John R Lee, Anthony Watkins, Jun B Lee, Darshana M Dadhania, Surya V Seshan, David Serur, Sandip Kapur, Manikkam Suthanthiran, Choli Hartono, Thangamani Muthukumar
We studied the causes and predictors of death-censored kidney allograft failure among 1670 kidney recipients transplanted at our center in the corticosteroid-free maintenance immunosuppression era. As of January 1, 2012, we identified 137 recipients with allograft failure; 130 of them (cases) were matched 1-1 for recipient age, calendar year of transplant and donor type with 130 recipients with functioning grafts (controls). Median time to allograft failure was 29 months (interquartile range 18-51). Physician validated and biopsy confirmed categories of allograft failure were: acute rejection (21%), glomerular disease (19%), transplant glomerulopathy (13%), interstitial fibrosis tubular atrophy (10%), and polyomavirus-associated nephropathy (7%)...
September 18, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28918487/clinical-risk-stratification-of-paediatric-renal-transplant-recipients-using-c1q-and-c3d-fixing-of-de-novo-donor-specific-antibodies
#2
Jon Jin Kim, Olivia Shaw, Chloe Martin, George Michaelides, Ramnath Balasubramaniam, Neil J Sebire, Nizam Mamode, Anthony Dorling, Robert Vaughan, Stephen D Marks
INTRODUCTION: We have previously shown that children who developed de novo donor-specific human leukocyte antigen (HLA) antibodies (DSA) had greater decline in allograft function. We hypothesised that patients with complement-activating DSA would have poorer renal allograft outcomes. METHODS: A total of 75 children developed DSA in the original study. The first positive DSA sample was subsequently tested for C1q and C3d fixing. The primary event was defined as 50% reduction from baseline estimated glomerular filtration rate and was analysed using the Kaplan-Meier estimator...
September 16, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28916139/online-adaptive-radiation-therapy
#3
REVIEW
Stephanie Lim-Reinders, Brian M Keller, Shahad Al-Ward, Arjun Sahgal, Anthony Kim
The current paradigm of radiation therapy has the treatment planned on a snapshot dataset of the patient's anatomy taken at the time of simulation. Throughout the course of treatment, this snapshot may vary from initial simulation. Although there is the ability to image patients within the treatment room with technologies such as cone beam computed tomography, the current state of the art is largely limited to rigid-body matching and not accounting for any geometric deformations in the patient's anatomy. A plan that was once attuned to the initial simulation can become suboptimal as the treatment progresses unless improved technologies are brought to bear...
April 24, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28901729/magnetic-field-dose-effects-on-different-radiation-beam-geometries-for-hypofractionated-partial-breast-irradiation
#4
Anthony Kim, Stephanie Lim-Reinders, Claire McCann, Syed Bilal Ahmad, Arjun Sahgal, Justin Lee, Brian M Keller
PURPOSE: Hypofractionated partial breast irradiation (HPBI) involves treatment to the breast tumor using high doses per fraction. Recent advances in MRI-Linac solutions have potential in being applied to HPBI due to gains in the soft tissue contrast of MRI; however, there are potentially deleterious effects of the magnetic field on the dose distribution. The purpose of this work is to determine the effects of the magnetic field on the dose distribution for HPBI tumors using a tangential beam arrangement (TAN), 5-beam intensity-modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT)...
September 13, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28888080/tg18-management-strategies-for-gallbladder-drainage-in-patients-with-acute-cholecystitis-updated-tokyo-guidelines-2018-with-videos
#5
Yasuhisa Mori, Takao Itoi, Todd H Baron, Tadahiro Takada, Steven M Strasberg, Henry A Pitt, Tomohiko Ukai, Satoru Shikata, Yoshinori Noguchi, Anthony Yuen Bun Teoh, Myung-Hwan Kim, Horacio J Asbun, Itaru Endo, Masamichi Yokoe, Fumihiko Miura, Kohji Okamoto, Kenji Suzuki, Akiko Umezawa, Yukio Iwashita, Taizo Hibi, Go Wakabayashi, Ho-Seong Han, Yoo-Seok Yoon, In-Seok Choi, Tsann-Long Hwang, Miin-Fu Chen, O James Garden, Harjit Singh, Kui-Hin Liau, Wayne Shih-Wei Huang, Dirk Joan Gouma, Giulio Belli, Christos Dervenis, Eduardo de Santibañes, Mariano Eduardo Giménez, John Albert Windsor, Wan Yee Lau, Daniel Cherqui, Palepu Jagannath, Avinash Nivritti Supe, Keng-Hao Liu, Cheng-Hsi Su, Daniel J Deziel, Xiao-Ping Chen, Sheung Tat Fan, Chen-Guo Ker, Eduard C Jonas, Robert Padbury, Shuntaro Mukai, Goro Honda, Atsushi Sugioka, Koji Asai, Ryota Higuchi, Keita Wada, Masahiro Yoshida, Toshihiko Mayumi, Koichi Hirata, Yoshinobu Sumiyama, Kazuo Inui, Masakazu Yamamoto
Since the publication of the Tokyo Guidelines in 2007 and their revision in 2013, appropriate management for acute cholecystitis has been more clearly established. Since the last revision, several manuscripts, especially for alternative endoscopic techniques, have been reported; therefore, additional evaluation and refinement of the 2013 Guidelines is required. We describe a standard drainage method for surgically high-risk patients with acute cholecystitis and the latest developed endoscopic gallbladder drainage techniques described in the updated Tokyo Guidelines 2018 (TG18)...
September 9, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28887134/decreased-non-specific-adhesivity-receptor-targeted-dart-nanoparticles-exhibit-improved-dispersion-cellular-uptake-and-tumor-retention-in-invasive-gliomas
#6
Aniket S Wadajkar, Jimena G Dancy, Nathan B Roberts, Nina P Connolly, Dudley K Strickland, Jeffrey A Winkles, Graeme F Woodworth, Anthony J Kim
The most common and deadly form of primary brain cancer, glioblastoma (GBM), is characterized by significant intratumoral heterogeneity, microvascular proliferation, immune system suppression, and brain tissue invasion. Delivering effective and sustained treatments to the invasive GBM cells intermixed with functioning neural elements is a major goal of advanced therapeutic systems for brain cancer. Previously, we investigated the nanoparticle characteristics that enable targeting of invasive GBM cells. This revealed the importance of minimizing non-specific binding within the relatively adhesive, 'sticky' microenvironment of the brain and brain tumors in particular...
September 5, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28884232/-18-f-av-1451-binding-to-neuromelanin-in-the-substantia-nigra-in-pd-and-psp
#7
Sarah Coakeley, Sang Soo Cho, Yuko Koshimori, Pablo Rusjan, Christine Ghadery, Jinhee Kim, Anthony E Lang, Sylvain Houle, Antonio P Strafella
This study investigated binding of [(18)F]AV-1451 to neuromelanin in the substantia nigra of patients with Parkinson's disease (PD) and progressive supranuclear palsy (PSP). [(18)F]AV-1451 is a positron emission tomography radiotracer designed to bind pathological tau. A post-mortem study using [(18)F]AV-1451 discovered off-target binding properties to neuromelanin in the substantia nigra. A subsequent clinical study reported a 30% decrease in [(18)F]AV-1451 binding in the midbrain of PD patients. A total of 12 patients and 10 healthy age-matched controls were recruited...
September 7, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28881801/a-screen-for-inducers-of-bhlh-activity-identifies-pitavastatin-as-a-regulator-of-p21-rb-phosphorylation-and-e2f-target-gene-expression-in-pancreatic-cancer
#8
Nicholas Villarino, Lia Signaevskaia, Jaco van Niekerk, Rachel Medal, Heejung Kim, Reyhaneh Lahmy, Kathleen Scully, Anthony Pinkerton, Sangwun Kim, Andrew Lowy, Pamela Itkin-Ansari
The average survival for patients with Pancreatic Ductal Adenocarcinoma (PDA) is merely 6 months, underscoring the need for new therapeutic approaches. During PDA progression, pancreatic acinar cells lose activity of the ClassI/II bHLH factors that regulate quiescence. We previously found that promoting transcriptional activity of the Class I bHLH factor E47 in highly aggressive PDA cells induced stable growth arrest in vitro and in vivo. To translate these findings for clinical utility, we developed a high throughput screening platform to identify small molecule inducers of Class I/II bHLH activity...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28874676/linc-ing-circulating-long-non-coding-rnas-to-the-diagnosis-and-malignant-prediction-of-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#9
Jennifer B Permuth, Dung-Tsa Chen, Sean J Yoder, Jiannong Li, Andrew T Smith, Jung W Choi, Jongphil Kim, Yoganand Balagurunathan, Kun Jiang, Domenico Coppola, Barbara A Centeno, Jason Klapman, Pam Hodul, Florian A Karreth, Jose G Trevino, Nipun Merchant, Anthony Magliocco, Mokenge P Malafa, Robert Gillies
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease that lacks effective biomarkers for early detection. We hypothesized that circulating long non-coding RNAs (lncRNAs) may act as diagnostic markers of incidentally-detected cystic PDAC precursors known as intraductal papillary mucinous neoplasms (IPMNs) and predictors of their pathology/histological classification. Using NanoString nCounter® technology, we measured the abundance of 28 candidate lncRNAs in pre-operative plasma from a cohort of pathologically-confirmed IPMN cases of various grades of severity and non-diseased controls...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28859922/the-role-of-multiorgan-procurement-for-abdominal-transplant-in-general-surgery-resident-education
#10
Johanna Bayer, Carol-Anne Moulton, Kimberley Monden, Robert M Goldstein, Gregory J McKenna, Giuliano Testa, Richard M Ruiz, Tiffany L Anthony, Nicholas Onaca, Goran B Klintmalm, Peter T W Kim
BACKGROUND: To assess the impact of participation of multiorgan procurement (MP) by general surgery (GS) residents on surgical knowledge and skills, a prospective cohort study of GS residents during transplant surgery rotation was performed. METHODS: Before and after participation in MPs, assessment of knowledge was performed by written pre and post tests and surgical skills by modified Objective Structured Assessment of Technical Skill (OSATS) score. Thirty-nine residents performed 84 MPs...
August 25, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28858559/more-is-meaningful-the-magnitude-effect-in-intertemporal-choice-depends-on-self-control
#11
Ian C Ballard, Bokyung Kim, Anthony Liatsis, Gökhan Aydogan, Jonathan D Cohen, Samuel M McClure
Impulsivity is a variable behavioral trait that depends on numerous factors. For example, increasing the absolute magnitude of available choice options promotes farsighted decisions. We argue that this magnitude effect arises in part from differential exertion of self-control as the perceived importance of the choice increases. First, we demonstrated that frontal executive-control areas were more engaged for more difficult decisions and that this effect was enhanced for high-magnitude rewards. Second, we showed that increased hunger, which is associated with lower self-control, reduced the magnitude effect...
August 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/28846070/proteasome-activity-regulates-cd8-t-lymphocyte-metabolism-and-fate-specification
#12
Christella E Widjaja, Jocelyn G Olvera, Patrick J Metz, Anthony T Phan, Jeffrey N Savas, Gerjan de Bruin, Yves Leestemaker, Celia R Berkers, Annemieke de Jong, Bogdan I Florea, Kathleen Fisch, Justine Lopez, Stephanie H Kim, Daniel A Garcia, Stephen Searles, Jack D Bui, Aaron N Chang, John R Yates, Ananda W Goldrath, Hermen S Overkleeft, Huib Ovaa, John T Chang
During an immune response, CD8+ T lymphocytes can undergo asymmetric division, giving rise to daughter cells that exhibit distinct tendencies to adopt terminal effector and memory cell fates. Here we show that "pre-effector" and "pre-memory" cells resulting from the first CD8+ T cell division in vivo exhibited low and high rates of endogenous proteasome activity, respectively. Pharmacologic reduction of proteasome activity in CD8+ T cells early during differentiation resulted in acquisition of terminal effector cell characteristics, whereas enhancement of proteasome activity conferred attributes of memory lymphocytes...
August 28, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28844181/changes-in-pressure-hemodynamics-and-metabolism-within-the-spinal-cord-during-the-first-7-days-after-injury-using-a-porcine-model
#13
Femke Streijger, Kitty So, Neda Manouchehri, Jae H T Lee, Elena B Okon, Katelyn Shortt, So-Eun Kim, Kurt McInnes, Peter Cripton, Brian K Kwon
Traumatic spinal cord injury (SCI) triggers many perturbations within the injured cord, such as decreased perfusion, reduced tissue oxygenation, increased hydrostatic pressure, and disrupted bioenergetics. While much attention is directed to neuroprotective interventions that might alleviate these early pathophysiologic responses to traumatic injury, the temporo-spatial characteristics of these responses within the injured cord are not well documented. In this study, we utilized our Yucatan mini-pig model of traumatic SCI to characterize intraparenchymal hemodynamic and metabolic changes within the spinal cord for 1 week post-injury...
September 14, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28835816/a-quantitative-multi-national-and-multi-stakeholder-assessment-of-barriers-to-the-adoption-of-cell-therapies
#14
Benjamin M Davies, James Smith, Sarah Rikabi, Karolina Wartolowska, Mark Morrey, Anna French, Robert MacLaren, David Williams, Kim Bure, Rafael Pinedo-Villanueva, Anthony Mathur, Martin Birchall, Evan Snyder, Anthony Atala, Brock Reeve, David Brindley
Cellular therapies, such as stem cell-based treatments, have been widely researched and numerous products and treatments have been developed. Despite this, there has been relatively limited use of these technologies in the healthcare sector. This study sought to investigate the perceived barriers to this more widespread adoption. An anonymous online questionnaire was developed, based on the findings of a pilot study. This was distributed to an audience of clinicians, researchers and commercial experts in 13 countries...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28834389/indications-and-techniques-of-biliary-drainage-for-acute-cholangitis-in-updated-tokyo-guidelines-2018
#15
Shuntaro Mukai, Takao Itoi, Todd H Baron, Tadahiro Takada, Steven M Strasberg, Henry A Pitt, Tomohiko Ukai, Satoru Shikata, Anthony Yuen Bun Teoh, Myung-Hwan Kim, Seiki Kiriyama, Yasuhisa Mori, Fumihiko Miura, Miin-Fu Chen, Wan Yee Lau, Keita Wada, Avinash Nivritti Supe, Mariano Eduardo Giménez, Masahiro Yoshida, Toshihiko Mayumi, Koichi Hirata, Yoshinobu Sumiyama, Kazuo Inui, Masakazu Yamamoto
The Tokyo guidelines 2013 (TG13) include new topics in the biliary drainage section. From these topics, we describe the indications and new techniques of biliary drainage for acute cholangitis with videos. Recently, many novel studies and case series have been published across the world, thus TG13 need to be updated regarding the indications and selection of biliary drainage based on published data. Herein, we describe the latest updated TG13 on biliary drainage in acute cholangitis with meta-analysis. The present study showed that endoscopic transpapillary biliary drainage regardless of the use of nasobiliary drainage or biliary stenting, should be selected as the first-line therapy for acute cholangitis...
August 19, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28829439/an-integrated-expression-atlas-of-mirnas-and-their-promoters-in-human-and-mouse
#16
Derek de Rie, Imad Abugessaisa, Tanvir Alam, Erik Arner, Peter Arner, Haitham Ashoor, Gaby Åström, Magda Babina, Nicolas Bertin, A Maxwell Burroughs, Ailsa J Carlisle, Carsten O Daub, Michael Detmar, Ruslan Deviatiiarov, Alexandre Fort, Claudia Gebhard, Daniel Goldowitz, Sven Guhl, Thomas J Ha, Jayson Harshbarger, Akira Hasegawa, Kosuke Hashimoto, Meenhard Herlyn, Peter Heutink, Kelly J Hitchens, Chung Chau Hon, Edward Huang, Yuri Ishizu, Chieko Kai, Takeya Kasukawa, Peter Klinken, Timo Lassmann, Charles-Henri Lecellier, Weonju Lee, Marina Lizio, Vsevolod Makeev, Anthony Mathelier, Yulia A Medvedeva, Niklas Mejhert, Christopher J Mungall, Shohei Noma, Mitsuhiro Ohshima, Mariko Okada-Hatakeyama, Helena Persson, Patrizia Rizzu, Filip Roudnicky, Pål Sætrom, Hiroki Sato, Jessica Severin, Jay W Shin, Rolf K Swoboda, Hiroshi Tarui, Hiroo Toyoda, Kristoffer Vitting-Seerup, Louise Winteringham, Yoko Yamaguchi, Kayoko Yasuzawa, Misako Yoneda, Noriko Yumoto, Susan Zabierowski, Peter G Zhang, Christine A Wells, Kim M Summers, Hideya Kawaji, Albin Sandelin, Michael Rehli, Yoshihide Hayashizaki, Piero Carninci, Alistair R R Forrest, Michiel J L de Hoon
MicroRNAs (miRNAs) are short non-coding RNAs with key roles in cellular regulation. As part of the fifth edition of the Functional Annotation of Mammalian Genome (FANTOM5) project, we created an integrated expression atlas of miRNAs and their promoters by deep-sequencing 492 short RNA (sRNA) libraries, with matching Cap Analysis Gene Expression (CAGE) data, from 396 human and 47 mouse RNA samples. Promoters were identified for 1,357 human and 804 mouse miRNAs and showed strong sequence conservation between species...
September 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28799084/the-significance-of-upfront-knowledge-of-n2-disease-in-non-small-cell-lung-cancer
#17
Daniel C Thomas, Brian N Arnold, Joshua E Rosen, Michelle C Salazar, Frank C Detterbeck, Justin D Blasberg, Daniel J Boffa, Anthony W Kim
BACKGROUND: Previous literature suggests that patients with non-small cell lung cancer (NSCLC) and unsuspected N2 disease (cN0, pN2) represent a distinct subgroup associated with improved overall survival compared to patients with N2 disease identified prior to resection (cN2, pN2). METHODS: Retrospective analysis of the National Cancer Database of patients from 2004 to 2011 with cN0 and cN2 status found to be pathologic stage III-N2 NSCLC after surgical resection...
August 10, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28798658/miniaturized-battery-free-wireless-systems-for-wearable-pulse-oximetry
#18
Jeonghyun Kim, Philipp Gutruf, Antonio M Chiarelli, Seung Yun Heo, Kyoungyeon Cho, Zhaoqian Xie, Anthony Banks, Seungyoung Han, Kyung-In Jang, Jung Woo Lee, Kyu-Tae Lee, Xue Feng, Yonggang Huang, Monica Fabiani, Gabriele Gratton, Ungyu Paik, John A Rogers
Development of unconventional technologies for wireless collection, storage and analysis of quantitative, clinically relevant information on physiological status is of growing interest. Soft, biocompatible systems are widely regarded as important because they facilitate mounting on external (e.g. skin) and internal (e.g. heart, brain) surfaces of the body. Ultra-miniaturized, lightweight and battery-free devices have the potential to establish complementary options in bio-integration, where chronic interfaces (i...
January 5, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28797259/gender-differences-in-hospital-admissions-for-major-cardiovascular-events-and-procedures-in-people-with-and-without-diabetes-in-england-a-nationwide-study-2004-2014
#19
Anthony A Laverty, Alex Bottle, Sung-Hee Kim, Bhakti Visani, Azeem Majeed, Christopher Millett, Eszter P Vamos
BACKGROUND: Secondary prevention of cardiovascular disease (CVD) has improved immensely during the past decade but controversies persist on cardiovascular benefits among women with diabetes. We investigated 11-year trends in hospital admission rates for acute myocardial infarction (AMI), stroke, percutaneous coronary intervention (PCI), and coronary artery bypass graft (CABG) in people with and without diabetes by gender in England. METHODS: We identified all hospital admissions for cardiovascular disease causes among people aged 17 years and above between 2004 and 2014 in England...
August 10, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28796559/improvements-in-patient-and-health-system-outcomes-using-an-integrated-oncology-and-palliative-medicine-approach-on-a-solid-tumor-inpatient-service
#20
Richard F Riedel, Kim Slusser, Steve Power, Christopher A Jones, Thomas W LeBlanc, Arif H Kamal, Devi Desai, Deborah Allen, Yinxi Yu, Steven Wolf, Anthony N Galanos
PURPOSE: Early palliative care (PC) improves outcomes for outpatients with advanced cancer. Its effect on hospitalized patients with cancer is unknown. Herein, we report on the influence of a novel, fully integrated inpatient medical oncology and PC partnership at a tertiary medical center during its first year of implementation. METHODS: We conducted a retrospective, longitudinal, pre- and postintervention cohort study at Duke University Hospital. Pre- and postintervention cohorts were defined as all patients admitted to the solid tumor inpatient service from September 1, 2009, to June 30, 2010, and September 1, 2011 to June 30, 2012, respectively...
September 2017: Journal of Oncology Practice
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