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Anthony kim

Neville K Kisalu, Azza H Idris, Connor Weidle, Yevel Flores-Garcia, Barbara J Flynn, Brandon K Sack, Sean Murphy, Arne Scho N, Ernesto Freire, Joseph R Francica, Alex B Miller, Jason Gregory, Sandra March, Hua-Xin Liao, Barton F Haynes, Kevin Wiehe, Ashley M Trama, Kevin O Saunders, Morgan A Gladden, Anthony Monroe, Mattia Bonsignori, Masaru Kanekiyo, Adam K Wheatley, Adrian B McDermott, S Katie Farney, Gwo-Yu Chuang, Baoshan Zhang, Natasha Kc, Sumana Chakravarty, Peter D Kwong, Photini Sinnis, Sangeeta N Bhatia, Stefan H I Kappe, B Kim Lee Sim, Stephen L Hoffman, Fidel Zavala, Marie Pancera, Robert A Seder
Development of a highly effective vaccine or antibodies for the prevention and ultimately elimination of malaria is urgently needed. Here we report the isolation of a number of human monoclonal antibodies directed against the Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP) from several subjects immunized with an attenuated Pf whole-sporozoite (SPZ) vaccine (Sanaria PfSPZ Vaccine). Passive transfer of one of these antibodies, monoclonal antibody CIS43, conferred high-level, sterile protection in two different mouse models of malaria infection...
March 19, 2018: Nature Medicine
Evdokiya Salamanova, Joana Costeira-Paulo, Kyou-Hoon Han, Do-Hyoung Kim, Lennart Nilsson, Anthony P H Wright
BACKGROUND: Adaptive mutations that alter protein functionality are enriched within intrinsically disordered protein regions (IDRs), thus conformational flexibility correlates with evolvability. Pre-structured motifs (PreSMos) with transient propensity for secondary structure conformation are believed to be important for IDR function. The glucocorticoid receptor tau1core transcriptional activation domain (GR tau1core) domain contains three α-helical PreSMos in physiological buffer conditions...
March 14, 2018: Biochimica et Biophysica Acta
Anushka C Galasiti Kankanamalage, Yunjeong Kim, Vishnu C Damalanka, Athri D Rathnayake, Anthony R Fehr, Nurjahan Mehzabeen, Kevin P Battaile, Scott Lovell, Gerald H Lushington, Stanley Perlman, Kyeong-Ok Chang, William C Groutas
There are currently no approved vaccines or small molecule therapeutics available for the prophylaxis or treatment of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infections. MERS-CoV 3CL protease is essential for viral replication; consequently, it is an attractive target that provides a potentially effective means of developing small molecule therapeutics for combatting MERS-CoV. We describe herein the structure-guided design and evaluation of a novel class of inhibitors of MERS-CoV 3CL protease that embody a piperidine moiety as a design element that is well-suited to exploiting favorable subsite binding interactions to attain optimal pharmacological activity and PK properties...
March 6, 2018: European Journal of Medicinal Chemistry
Orrin Devinsky, Daniel Friedman, Jocelyn Y Cheng, Ellen Moffatt, Anthony Kim, Zian H Tseng
No abstract text is available yet for this article.
March 13, 2018: Neurology
Jonathan R Young, Heidi Coy, Hyun J Kim, Michael Douek, Anthony Sisk, Arie Belldegrun, Allan J Pantuck, Steven S Raman
PURPOSE: To investigate if multiphasic multidetector computed tomography (MDCT) enhancement profiles can distinguish clear cell renal cell carcinomas (ccRCCs) with high carbonic anhydrase-IX (CA-IX) expression from ccRCCs with low CA-IX expression. METHODS: With IRB approval for this retrospective study, we derived a cohort of 105 histologically proven ccRCCs with preoperative 4-phase renal mass MDCT from 2001 to 2013. Following manual segmentation, the computer-assisted detection algorithm selected a 0...
March 8, 2018: Abdominal Radiology
Sarah J Mitchell, Michel Bernier, Miguel A Aon, Sonia Cortassa, Eun Young Kim, Evandro F Fang, Hector H Palacios, Ahmed Ali, Ignacio Navas-Enamorado, Andrea Di Francesco, Tamzin A Kaiser, Tyler B Waltz, Ning Zhang, James L Ellis, Peter J Elliott, David W Frederick, Vilhelm A Bohr, Mark S Schmidt, Charles Brenner, David A Sinclair, Anthony A Sauve, Joseph A Baur, Rafael de Cabo
The role in longevity and healthspan of nicotinamide (NAM), the physiological precursor of NAD+ , is elusive. Here, we report that chronic NAM supplementation improves healthspan measures in mice without extending lifespan. Untargeted metabolite profiling of the liver and metabolic flux analysis of liver-derived cells revealed NAM-mediated improvement in glucose homeostasis in mice on a high-fat diet (HFD) that was associated with reduced hepatic steatosis and inflammation concomitant with increased glycogen deposition and flux through the pentose phosphate and glycolytic pathways...
March 6, 2018: Cell Metabolism
Hyoungkyu Kim, Anthony G Hudetz, Joseph Lee, George A Mashour, UnCheol Lee
The integrated information theory (IIT) proposes a quantitative measure, denoted as Φ, of the amount of integrated information in a physical system, which is postulated to have an identity relationship with consciousness. IIT predicts that the value of Φ estimated from brain activities represents the level of consciousness across phylogeny and functional states. Practical limitations, such as the explosive computational demands required to estimate Φ for real systems, have hindered its application to the brain and raised questions about the utility of IIT in general...
2018: Frontiers in Human Neuroscience
Daniel C Thomas, Brian N Arnold, Jessica R Hoag, Michelle C Salazar, Daniel J Boffa, Frank C Detterbeck, Anthony W Kim, Justin D Blasberg
BACKGROUND: Few studies have examined the risk factors and timing of venous thromboembolism (VTE) in patients undergoing surgery for lung cancer, and there is limited data to formulate guidelines for extended VTE prophylaxis after hospital discharge. This study sought to identify risk factors for post-discharge VTE following lung resection. METHODS: Patients undergoing anatomic resection for lung cancer were identified in the National Surgical Quality Improvement Program database from 2005-2015...
March 1, 2018: Annals of Thoracic Surgery
Mataroria P Lyndon, Michael P Cassidy, Leo Anthony Celi, Luk Hendrik, Yoon Jeon Kim, Nicholas Gomez, Nathaniel Baum, Lucas Bulgarelli, Kenneth E Paik, Alon Dagan
OBJECTIVE: Machine learning in healthcare, and innovative healthcare technology in general, require complex interactions within multidisciplinary teams. Healthcare hackathons are being increasingly used as a model for cross-disciplinary collaboration and learning. The aim of this study is to explore high school student learning experiences during a healthcare hackathon. By optimizing their learning experiences, we hope to prepare a future workforce that can bridge technical and health fields and work seamlessly across disciplines...
April 2018: International Journal of Medical Informatics
Tao Zhang, Yen-Ching Wu, Patrick Mullane, Yon Ju Ji, Honghe Liu, Lu He, Amit Arora, Ho-Yon Hwang, Amelia F Alessi, Amirhossein G Niaki, Goran Periz, Lin Guo, Hejia Wang, Elad Elkayam, Leemor Joshua-Tor, Sua Myong, John K Kim, James Shorter, Shao-En Ong, Anthony K L Leung, Jiou Wang
MicroRNA-mediated gene silencing is a fundamental mechanism in the regulation of gene expression. It remains unclear how the efficiency of RNA silencing could be influenced by RNA-binding proteins associated with the microRNA-induced silencing complex (miRISC). Here we report that fused in sarcoma (FUS), an RNA-binding protein linked to neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), interacts with the core miRISC component AGO2 and is required for optimal microRNA-mediated gene silencing...
March 1, 2018: Molecular Cell
Pierce K H Chow, Mihir Gandhi, Say-Beng Tan, Maung Win Khin, Ariunaa Khasbazar, Janus Ong, Su Pin Choo, Peng Chung Cheow, Chanisa Chotipanich, Kieron Lim, Laurentius A Lesmana, Tjakra W Manuaba, Boon Koon Yoong, Aloysius Raj, Chiong Soon Law, Ian H Y Cua, Rolley R Lobo, Catherine S C Teh, Yun Hwan Kim, Yun Won Jong, Ho-Seong Han, Si-Hyun Bae, Hyun-Ki Yoon, Rheun-Chuan Lee, Chien-Fu Hung, Cheng-Yuan Peng, Po-Chin Liang, Adam Bartlett, Kenneth Y Y Kok, Choon-Hua Thng, Albert Su-Chong Low, Anthony S W Goh, Kiang Hiong Tay, Richard H G Lo, Brian K P Goh, David C E Ng, Ganesh Lekurwale, Wei Ming Liew, Val Gebski, Kenneth S W Mak, Khee Chee Soo
Purpose Selective internal radiation therapy or radioembolization (RE) shows efficacy in unresectable hepatocellular carcinoma (HCC) limited to the liver. This study compared the safety and efficacy of RE and sorafenib in patients with locally advanced HCC. Patients and Methods SIRveNIB (selective internal radiation therapy v sorafenib), an open-label, investigator-initiated, phase III trial, compared yttrium-90 (90 Y) resin microspheres RE with sorafenib 800 mg/d in patients with locally advanced HCC in a two-tailed study designed for superiority/detriment...
March 2, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Ángel F Adames, Daehyun Kim, Adam H Sobel, Anthony Del Genio, Jingbo Wu
The processes that lead to changes in the propagation and maintenance of the Madden-Julian Oscillation (MJO) as a response to increasing CO2 are examined by analyzing moist static energy budget of the MJO in a series of NASA GISS model simulations. It is found changes in MJO propagation is dominated by several key processes. Horizontal moisture advection, a key process for MJO propagation, is found to enhance predominantly due to an increase in the mean horizontal moisture gradients. The terms that determine the strength of the advecting wind anomalies, the MJO horizontal scale and the dry static stability, are found to exhibit opposing trends that largely cancel out...
December 2017: Journal of Advances in Modeling Earth Systems
Paul Y Kim, Anthony D Dinsmore, David A Hoagland, Thomas P Russell
Wetting, meniscus structure, and capillary interactions for polystyrene microspheres deposited on constant curvature cylindrical liquid interfaces, constructed from nonvolatile ionic or oligomeric liquids, were studied by optical interferometry and optical microscopy. The liquid interface curvature resulted from the preferential wetting of finite width lines patterned onto planar silicon substrates. Key variables included sphere diameter, nominal (or average) contact angle, and deviatoric interfacial curvature...
February 28, 2018: Soft Matter
Steven T Lanier, Kevin C Lewis, Mark C Kendall, Brittany L Vieira, Gildasio De Oliveira, Anthony Nader, John Y S Kim, Mohammed Alghoul
BACKGROUND: The authors' study represents the first level I evidence to assess whether intraoperative nerve blocks improve the quality of recovery from immediate tissue expander/implant breast reconstruction. METHODS: A prospective, randomized, double-blinded, placebo-controlled clinical trial was conducted in which patients undergoing immediate tissue expander/implant breast reconstruction were randomized to either (1) intraoperative intercostal and pectoral nerve blocks with 0...
March 2018: Plastic and Reconstructive Surgery
Steven M Garcia, Stanley Tamaki, Solomon Lee, Alvin Wong, Anthony Jose, Joanna Dreux, Gayle Kouklis, Hani Sbitany, Rahul Seth, P Daniel Knott, Chase Heaton, William R Ryan, Esther A Kim, Scott L Hansen, William Y Hoffman, Jason H Pomerantz
Investigation of human muscle regeneration requires robust methods to purify and transplant muscle stem and progenitor cells that collectively constitute the human satellite cell (HuSC) pool. Existing approaches have yet to make HuSCs widely accessible for researchers, and as a result human muscle stem cell research has advanced slowly. Here, we describe a robust and predictable HuSC purification process that is effective for each human skeletal muscle tested and the development of storage protocols and transplantation models in dystrophin-deficient and wild-type recipients...
February 15, 2018: Stem Cell Reports
Stella H Kim, Adriana M Strutt, Laiene Olabarrieta-Landa, Anthony H Lequerica, Diego Rivera, Carlos Jose De Los Reyes Aragon, Oscar Utria, Juan Carlos Arango-Lasprilla
OBJECTIVE: The Boston Naming Test (BNT) is a widely used measure of confrontation naming ability that has been criticized for its questionable construct validity for non-English speakers. This study investigated item difficulty and construct validity of the Spanish version of the BNT to assess cultural and linguistic impact on performance. METHODS: Subjects were 1298 healthy Spanish speaking adults from Colombia. They were administered the 60- and 15-item Spanish version of the BNT...
February 23, 2018: Clinical Neuropsychologist
Michael O'Donnell, Leif D Nelson, Evi Ackermann, Balazs Aczel, Athfah Akhtar, Silvio Aldrovandi, Nasseem Alshaif, Ronald Andringa, Mark Aveyard, Peter Babincak, Nursena Balatekin, Scott A Baldwin, Gabriel Banik, Ernest Baskin, Raoul Bell, Olga Białobrzeska, Angie R Birt, Walter R Boot, Scott R Braithwaite, Jessie C Briggs, Axel Buchner, Desiree Budd, Kathryn Budzik, Lottie Bullens, Richard L Bulley, Peter R Cannon, Katarzyna Cantarero, Joseph Cesario, Stephanie Chambers, Christopher R Chartier, Peggy Chekroun, Clara Chong, Axel Cleeremans, Sean P Coary, Jacob Coulthard, Florien M Cramwinckel, Thomas F Denson, Marcos Díaz-Lago, Theresa E DiDonato, Aaron Drummond, Julia Eberlen, Titus Ebersbach, John E Edlund, Katherine M Finnigan, Justin Fisher, Natalia Frankowska, Efraín García-Sánchez, Frank D Golom, Andrew J Graves, Kevin Greenberg, Mando Hanioti, Heather A Hansen, Jenna A Harder, Erin R Harrell, Andree Hartanto, Michael Inzlicht, David J Johnson, Andrew Karpinski, Victor N Keller, Olivier Klein, Lina Koppel, Emiel Krahmer, Anthony Lantian, Michael J Larson, Jean-Baptiste Légal, Richard E Lucas, Dermot Lynott, Corey M Magaldino, Karlijn Massar, Matthew T McBee, Neil McLatchie, Nadhilla Melia, Michael C Mensink, Laura Mieth, Samantha Moore-Berg, Geraldine Neeser, Ben R Newell, Marret K Noordewier, Asil Ali Özdogğru, Myrto Pantazi, Michał Parzuchowski, Kim Peters, Michael C Philipp, Monique M H Pollmann, Panagiotis Rentzelas, Rosa Rodríguez-Bailón, Jan Philipp Röer, Ivan Ropovik, Nelson A Roque, Carolina Rueda, Bastiaan T Rutjens, Katey Sackett, Janos Salamon, Ángel Sánchez-Rodríguez, Blair Saunders, Juliette Schaafsma, Michael Schulte-Mecklenbeck, David R Shanks, Martin F Sherman, Kenneth M Steele, Niklas K Steffens, Jessie Sun, Kyle J Susa, Barnabas Szaszi, Aba Szollosi, Ricardo M Tamayo, Gustav Tinghög, Yuk-Yue Tong, Carol Tweten, Miguel A Vadillo, Deisy Valcarcel, Nicolas Van der Linden, Michiel van Elk, Frenk van Harreveld, Daniel Västfjäll, Simine Vazire, Philippe Verduyn, Matt N Williams, Guillermo B Willis, Sarah E Wood, Chunliang Yang, Oulmann Zerhouni, Robert Zheng, Mark Zrubka
Dijksterhuis and van Knippenberg (1998) reported that participants primed with a category associated with intelligence ("professor") subsequently performed 13% better on a trivia test than participants primed with a category associated with a lack of intelligence ("soccer hooligans"). In two unpublished replications of this study designed to verify the appropriate testing procedures, Dijksterhuis, van Knippenberg, and Holland observed a smaller difference between conditions (2%-3%) as well as a gender difference: Men showed the effect (9...
February 1, 2018: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
Kristoffer Ostridge, Nicholas P Williams, Viktoriya Kim, Stephen Harden, Simon Bourne, Stuart C Clarke, Emmanuel Aris, Sonia Mesia-Vela, Jeanne-Marie Devaster, Andrew Tuck, Anthony Williams, Stephen Wootton, Karl J Staples, Tom M A Wilkinson
BACKGROUND: COPD is a complex, heterogeneous disease characterised by progressive development of airflow limitation. Spirometry provides little information about key aspects of pathology and is poorly related to clinical outcome, so other tools are required to investigate the disease. We sought to explore the relationships between quantitative CT analysis with functional, inflammatory and infective assessments of disease to identify the utility of imaging to stratify disease to better predict outcomes and disease response...
February 20, 2018: Respiratory Research
David S Hersh, Sen Peng, Jimena G Dancy, Rebeca Galisteo, Jennifer M Eschbacher, Rudy J Castellani, Jonathan E Heath, Teklu Legesse, Anthony J Kim, Graeme F Woodworth, Nhan L Tran, Jeffrey A Winkles
The TNF receptor superfamily member Fn14 is overexpressed by many solid tumor types, including glioblastoma (GBM), the most common and lethal form of adult brain cancer. GBM is notable for a highly infiltrative growth pattern and several groups have reported that high Fn14 expression levels can increase tumor cell invasiveness. We reported previously that the mesenchymal and proneural GBM transcriptomic subtypes expressed the highest and lowest levels of Fn14 mRNA, respectively. Given the recent histopathological re-classification of human gliomas by the World Health Organization based on isocitrate dehydrogenase 1 (IDH1) gene mutation status, we extended this work by comparing Fn14 gene expression in IDH1 wild-type (WT) and mutant (R132H) gliomas and in cell lines engineered to overexpress the IDH1 R132H enzyme...
February 16, 2018: Journal of Neuro-oncology
Emanual Maverakis, Chelsea Ma, Kanade Shinkai, David Fiorentino, Jeffrey P Callen, Uwe Wollina, Angelo Valerio Marzano, Daniel Wallach, Kyoungmi Kim, Courtney Schadt, Anthony Ormerod, Maxwell A Fung, Andrea Steel, Forum Patel, Rosie Qin, Fiona Craig, Hywel C Williams, Frank Powell, Alexander Merleev, Michelle Y Cheng
Importance: Pyoderma gangrenosum is a rare inflammatory skin condition that is difficult to diagnose. Currently, it is a "diagnosis of exclusion," a definition not compatible with clinical decision making or inclusion for clinical trials. Objective: To propose and validate diagnostic criteria for ulcerative pyoderma gangrenosum. Evidence Review: Diagnostic criteria were created following a Delphi consensus exercise using the RAND/UCLA Appropriateness Method...
February 14, 2018: JAMA Dermatology
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