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https://www.readbyqxmd.com/read/27924941/progressive-muscle-cell-delivery-as-a-solution-for-volumetric-muscle-defect-repair
#1
Ji Hyun Kim, In Kap Ko, Anthony Atala, James J Yoo
Reconstructing functional volumetric tissue in vivo following implantation remains a critical challenge facing cell-based approaches. Several pre-vascularization approaches have been developed to increase cell viability following implantation. Structural and functional restoration was achieved in a preclinical rodent tissue defect; however, the approach used in this model fails to repair larger (>mm) defects as observed in a clinical setting. We propose an effective cell delivery system utilizing appropriate vascularization at the site of cell implantation that results in volumetric and functional tissue reconstruction...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27922813/transcatheter-tricuspid-repair-with-mitraclip-for-severe-primary-tricuspid-regurgitation
#2
Neil P Fam, Kim A Connelly, Christoph Hammerstingl, Geraldine Ong, Anthony W A Wassef, Heather J Ross, Subodh Verma
Severe tricuspid regurgitation is an independent predictor of adverse outcomes, yet few patients undergo surgery and treatment with medical therapy is often inadequate. Recent studies have reported the use of the MitraClip system (Abbott Vascular) to treat secondary tricuspid regurgitation. We describe the first use of MitraClip to treat severe primary tricuspid regurgitation and right heart failure in a patient with previous cardiac transplantation and high surgical risk.
December 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27894306/first-phase-i-human-clinical-trial-of-a-killed-whole-hiv-1-vaccine-demonstration-of-its-safety-and-enhancement-of-anti-hiv-antibody-responses
#3
Eunsil Choi, Chad J Michalski, Seung Ho Choo, Gyoung Nyoun Kim, Elizabeth Banasikowska, Sangkyun Lee, Kunyu Wu, Hwa-Yong An, Anthony Mills, Stefan Schneider, U Fritz Bredeek, Daniel R Coulston, Shilei Ding, Andrés Finzi, Meijuan Tian, Katja Klein, Eric J Arts, Jamie F S Mann, Yong Gao, C Yong Kang
BACKGROUND: Vaccination with inactivated (killed) whole-virus particles has been used to prevent a wide range of viral diseases. However, for an HIV vaccine this approach has been largely negated due to inherent safety concerns, despite the ability of killed whole-virus vaccines to generate a strong, predominantly antibody-mediated immune response in vivo. HIV-1 Clade B NL4-3 was genetically modified by deleting the nef and vpu genes and substituting the coding sequence for the Env signal peptide with that of honeybee melittin signal peptide to produce a less virulent and more replication efficient virus...
November 28, 2016: Retrovirology
https://www.readbyqxmd.com/read/27890561/role-of-adjuvant-therapy-for-node-negative-lung-cancer-invading-the-chest-wall
#4
Sarah J Gao, Christopher D Corso, Justin D Blasberg, Frank C Detterbeck, Daniel J Boffa, Roy H Decker, Anthony W Kim
INTRODUCTION: The present study investigated the effect of adjuvant chemotherapy and radiation on survival among patients undergoing chest wall resection for T3N0 non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Patients with T3N0 NSCLC who underwent chest wall resection were identified in the National Cancer Data Base in 2004 to 2012. The cohort was divided into patients who had received adjuvant chemotherapy, radiation therapy, chemoradiation therapy, or no adjuvant treatment...
October 17, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27882407/a-novel-system-for-correcting-large-scale-chromosomal-aberrations-ring-chromosome-correction-via-reprogramming-into-induced-pluripotent-stem-cell-ipsc
#5
REVIEW
Taehyun Kim, Kathleen Plona, Anthony Wynshaw-Boris
Approximately 1 in 500 newborns are born with chromosomal abnormalities that include trisomies, translocations, large deletions, and duplications. There is currently no therapeutic approach for correcting such chromosomal aberrations in vivo or in vitro. When we attempted to produce induced pluripotent stem cell (iPSC) models from patient-derived fibroblasts that contained ring chromosomes, we found that the ring chromosomes were eliminated and replaced by duplicated normal copies of chromosomes through a mechanism of uniparental isodisomy (Bershteyn et al...
November 23, 2016: Chromosoma
https://www.readbyqxmd.com/read/27881826/a-soft-wearable-microfluidic-device-for-the-capture-storage-and-colorimetric-sensing-of-sweat
#6
Ahyeon Koh, Daeshik Kang, Yeguang Xue, Seungmin Lee, Rafal M Pielak, Jeonghyun Kim, Taehwan Hwang, Seunghwan Min, Anthony Banks, Philippe Bastien, Megan C Manco, Liang Wang, Kaitlyn R Ammann, Kyung-In Jang, Phillip Won, Seungyong Han, Roozbeh Ghaffari, Ungyu Paik, Marvin J Slepian, Guive Balooch, Yonggang Huang, John A Rogers
Capabilities in health monitoring enabled by capture and quantitative chemical analysis of sweat could complement, or potentially obviate the need for, approaches based on sporadic assessment of blood samples. Established sweat monitoring technologies use simple fabric swatches and are limited to basic analysis in controlled laboratory or hospital settings. We present a collection of materials and device designs for soft, flexible, and stretchable microfluidic systems, including embodiments that integrate wireless communication electronics, which can intimately and robustly bond to the surface of the skin without chemical and mechanical irritation...
November 23, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27870977/longitudinal-treatment-patterns-with-adp-receptor-inhibitors-after-myocardial-infarction-insights-from-the-canadian-observational-antiplatelet-study
#7
Akshay Bagai, Tracy Y Wang, Shaun G Goodman, Harold N Fisher, Robert C Welsh, Jean-Pierre Dery, Xiang Zhang, Yajun E Zhu, Asim N Cheema, Payam Dehghani, Saleem A Kassam, John Ducas, Neil Brass, Hahn Hoe Kim, Anthony Fung, Erick Schampaert, Ata Ur Rehman Quraishi, Shamir R Mehta
BACKGROUND: After myocardial infarction (MI) treated with percutaneous coronary intervention (PCI), guidelines recommend dual antiplatelet therapy (DAPT) with aspirin and an ADP receptor inhibitor (ADPri) for at least 1year. However, whether real-world Canadian practice patterns reflect this recommendation is unknown. METHODS: We studied 2175 MI patients treated with PCI and discharged from 26 Canadian hospitals between 12/2011 and 05/2013 in the Canadian Observational Antiplatelet sTudy (COAPT)...
November 14, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27851669/wrist-accelerometer-cut-points-for-classifying-sedentary-behavior-in-children
#8
Christiana M T van Loo, Anthony D Okely, Marijka J Batterham, Trina Hinkley, Ulf Ekelund, Søren Brage, John J Reilly, Stewart G Trost, Rachel A Jones, Xanne Janssen, Dylan P Cliff
INTRODUCTION: To examine the validity and accuracy of wrist accelerometers for classifying sedentary behavior (SB) in children. METHODS: Fifty-seven children (5-8y and 9-12y) completed a ~170min protocol including 15 semi-structured activities and transitions. Nine ActiGraph (GT3X+) and two GENEActiv wrist cut-points were evaluated. Direct observation was the criterion measure. The accuracy of wrist cut-points was compared to that achieved by the ActiGraph hip cut-point (≤25 counts/15s) and the thigh-mounted activPAL3...
November 16, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27821083/single-administration-of-selective-internal-radiation-therapy-versus-continuous-treatment-with-sorafenib-in-locally-advanced-hepatocellular-carcinoma-sirvenib-study-protocol-for-a-phase-iii-randomized-controlled-trial
#9
Mihir Gandhi, Su Pin Choo, Choon Hua Thng, Say Beng Tan, Albert Su Chong Low, Peng Chung Cheow, Anthony Soon Whatt Goh, Kiang Hiong Tay, Richard Hoau Gong Lo, Brian Kim Poh Goh, Jen San Wong, David Chee Eng Ng, Khee Chee Soo, Wei Ming Liew, Pierce K H Chow
BACKGROUND: Approximately 20 % of hepatocellular carcinoma (HCC) patients diagnosed in the early stages may benefit from potentially curative ablative therapies such as surgical resection, transplantation or radiofrequency ablation. For patients not eligible for such options, prognosis is poor. Sorafenib and Selective Internal Radiation Therapy (SIRT) are clinically proven treatment options in patients with unresectable HCC, and this study aims to assess overall survival following either SIRT or Sorafenib therapy for locally advanced HCC patients...
November 7, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27818097/a-surrogate-marker-of-piperaquine-resistant-plasmodium-falciparum-malaria-a-phenotype-genotype-association-study
#10
Benoit Witkowski, Valentine Duru, Nimol Khim, Leila S Ross, Benjamin Saintpierre, Johann Beghain, Sophy Chy, Saorin Kim, Sopheakvatey Ke, Nimol Kloeung, Rotha Eam, Chanra Khean, Malen Ken, Kaknika Loch, Anthony Bouillon, Anais Domergue, Laurence Ma, Christiane Bouchier, Rithea Leang, Rekol Huy, Grégory Nuel, Jean-Christophe Barale, Eric Legrand, Pascal Ringwald, David A Fidock, Odile Mercereau-Puijalon, Frédéric Ariey, Didier Ménard
BACKGROUND: Western Cambodia is the epicentre of Plasmodium falciparum multidrug resistance and is facing high rates of dihydroartemisinin-piperaquine treatment failures. Genetic tools to detect the multidrug-resistant parasites are needed. Artemisinin resistance can be tracked using the K13 molecular marker, but no marker exists for piperaquine resistance. We aimed to identify genetic markers of piperaquine resistance and study their association with dihydroartemisinin-piperaquine treatment failures...
November 3, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27813323/tumor-targeted-nanotherapeutics-overcoming-treatment-barriers-for-glioblastoma
#11
REVIEW
Aniket S Wadajkar, Jimena G Dancy, David S Hersh, Pavlos Anastasiadis, Nhan L Tran, Graeme F Woodworth, Jeffrey A Winkles, Anthony J Kim
Glioblastoma (GBM) is a highly aggressive and lethal form of primary brain cancer. Numerous barriers exist to the effective treatment of GBM including the tightly controlled interface between the bloodstream and central nervous system termed the 'neurovascular unit,' a narrow and tortuous tumor extracellular space containing a dense meshwork of proteins and glycosaminoglycans, and genomic heterogeneity and instability. A major goal of GBM therapy is achieving sustained drug delivery to glioma cells while minimizing toxicity to adjacent neurons and glia...
November 4, 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/27813255/chromosome-therapy-potential-strategies-for-the-correction-of-severe-chromosome-aberrations
#12
Kathleen Plona, Taehyun Kim, Katherine Halloran, Anthony Wynshaw-Boris
Large chromosomal aberrations occur commonly during development, resulting in complex and multisystem diseases. In spite of this high frequency, there are currently no means for correcting these disorders due to their complexity and involvement of multiple genes. Recently, several new approaches have been devised that target whole chromosomes in vitro, which are collectively referred to as "Chromosome Therapies." These include silencing and selection for loss of the extra chromosome in trisomies, promotion of euploidy in an aneuploid culture, and forced loss and replacement of a chromosome...
November 3, 2016: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/27809511/on-the-origins-of-non-radiative-excited-state-relaxation-in-aryl-sulfoxides-relevant-to-fluorescent-chemosensing
#13
Rahul S Kathayat, Lijun Yang, Tosaporn Sattasathuchana, Laura Zoppi, Kim K Baldridge, Anthony Linden, Nathaniel S Finney
We provide herein a mechanistic analysis of aryl sulfoxide excited state processes, inspired by our recent report of aryl sulfoxide-based fluorescent chemosensors. The use of aryl sulfoxides as reporting elements in chemosensor development is a significant deviation from previous approaches, and thus warrants closer examination. We demonstrate that metal ion binding suppresses non-radiative excited state decay by blocking formation of a previously unrecognized charge transfer excited state, leading to fluorescence enhancement...
November 3, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27790103/a-voxel-based-morphometry-study-reveals-local-brain-structural-alterations-associated-with-ambient-fine-particles-in-older-women
#14
Ramon Casanova, Xinhui Wang, Jeanette Reyes, Yasuyuki Akita, Marc L Serre, William Vizuete, Helena C Chui, Ira Driscoll, Susan M Resnick, Mark A Espeland, Jiu-Chiuan Chen
Objective: Exposure to ambient fine particulate matter (PM2.5: PM with aerodynamic diameters < 2.5 μm) has been linked with cognitive deficits in older adults. Using fine-grained voxel-wise analyses, we examined whether PM2.5 exposure also affects brain structure. Methods: Brain MRI data were obtained from 1365 women (aged 71-89) in the Women's Health Initiative Memory Study and local brain volumes were estimated using RAVENS (regional analysis of volumes in normalized space). Based on geocoded residential locations and air monitoring data from the U...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27782854/molecular-profiling-of-advanced-solid-tumors-and-patient-outcomes-with-genotype-matched-clinical-trials-the-princess-margaret-impact-compact-trial
#15
Tracy L Stockley, Amit M Oza, Hal K Berman, Natasha B Leighl, Jennifer J Knox, Frances A Shepherd, Eric X Chen, Monika K Krzyzanowska, Neesha Dhani, Anthony M Joshua, Ming-Sound Tsao, Stefano Serra, Blaise Clarke, Michael H Roehrl, Tong Zhang, Mahadeo A Sukhai, Nadia Califaretti, Mateya Trinkaus, Patricia Shaw, Theodorus van der Kwast, Lisa Wang, Carl Virtanen, Raymond H Kim, Albiruni R A Razak, Aaron R Hansen, Celeste Yu, Trevor J Pugh, Suzanne Kamel-Reid, Lillian L Siu, Philippe L Bedard
BACKGROUND: The clinical utility of molecular profiling of tumor tissue to guide treatment of patients with advanced solid tumors is unknown. Our objectives were to evaluate the frequency of genomic alterations, clinical "actionability" of somatic variants, enrollment in mutation-targeted or other clinical trials, and outcome of molecular profiling for advanced solid tumor patients at the Princess Margaret Cancer Centre (PM). METHODS: Patients with advanced solid tumors aged ≥18 years, good performance status, and archival tumor tissue available were prospectively consented...
October 25, 2016: Genome Medicine
https://www.readbyqxmd.com/read/27782209/carbon-nanotubes-allow-capture-of-krypton-barium-and-lead-for-multichannel-biological-x-ray-fluorescence-imaging
#16
Christopher J Serpell, Reida N Rutte, Kalotina Geraki, Elzbieta Pach, Markus Martincic, Magdalena Kierkowicz, Sonia De Munari, Kim Wals, Ritu Raj, Belén Ballesteros, Gerard Tobias, Daniel C Anthony, Benjamin G Davis
The desire to study biology in situ has been aided by many imaging techniques. Among these, X-ray fluorescence (XRF) mapping permits observation of elemental distributions in a multichannel manner. However, XRF imaging is underused, in part, because of the difficulty in interpreting maps without an underlying cellular 'blueprint'; this could be supplied using contrast agents. Carbon nanotubes (CNTs) can be filled with a wide range of inorganic materials, and thus can be used as 'contrast agents' if biologically absent elements are encapsulated...
October 26, 2016: Nature Communications
https://www.readbyqxmd.com/read/27780786/the-8-th-edition-lung-cancer-stage-classification
#17
REVIEW
Frank C Detterbeck, Daniel J Boffa, Anthony W Kim, Lynn T Tanoue
Stage classification provides a nomenclature about the anatomic extent of a cancer; a consistent language provides the ability to communicate about a specific patient and about cohorts of patients in clinical studies. This paper summarizes the 8(th) edition of lung cancer stage classification, which is the worldwide standard as of January 1, 2017. This revision is based on a large global database, a sophisticated analysis, extensive internal validation as well as multiple assessments confirming generalizability...
October 22, 2016: Chest
https://www.readbyqxmd.com/read/27775925/a-facility-to-search-for-hidden-particles-at-the-cern-sps-the-ship-physics-case
#18
Sergey Alekhin, Wolfgang Altmannshofer, Takehiko Asaka, Brian Batell, Fedor Bezrukov, Kyrylo Bondarenko, Alexey Boyarsky, Ki-Young Choi, Cristóbal Corral, Nathaniel Craig, David Curtin, Sacha Davidson, André de Gouvêa, Stefano Dell'Oro, Patrick deNiverville, P S Bhupal Dev, Herbi Dreiner, Marco Drewes, Shintaro Eijima, Rouven Essig, Anthony Fradette, Björn Garbrecht, Belen Gavela, Gian F Giudice, Mark D Goodsell, Dmitry Gorbunov, Stefania Gori, Christophe Grojean, Alberto Guffanti, Thomas Hambye, Steen H Hansen, Juan Carlos Helo, Pilar Hernandez, Alejandro Ibarra, Artem Ivashko, Eder Izaguirre, Joerg Jaeckel, Yu Seon Jeong, Felix Kahlhoefer, Yonatan Kahn, Andrey Katz, Choong Sun Kim, Sergey Kovalenko, Gordan Krnjaic, Valery E Lyubovitskij, Simone Marcocci, Matthew Mccullough, David McKeen, Guenakh Mitselmakher, Sven-Olaf Moch, Rabindra N Mohapatra, David E Morrissey, Maksym Ovchynnikov, Emmanuel Paschos, Apostolos Pilaftsis, Maxim Pospelov, Mary Hall Reno, Andreas Ringwald, Adam Ritz, Leszek Roszkowski, Valery Rubakov, Oleg Ruchayskiy, Ingo Schienbein, Daniel Schmeier, Kai Schmidt-Hoberg, Pedro Schwaller, Goran Senjanovic, Osamu Seto, Mikhail Shaposhnikov, Lesya Shchutska, Jessie Shelton, Robert Shrock, Brian Shuve, Michael Spannowsky, Andy Spray, Florian Staub, Daniel Stolarski, Matt Strassler, Vladimir Tello, Francesco Tramontano, Anurag Tripathi, Sean Tulin, Francesco Vissani, Martin W Winkler, Kathryn M Zurek
This paper describes the physics case for a new fixed target facility at CERN SPS. The SHiP (search for hidden particles) experiment is intended to hunt for new physics in the largely unexplored domain of very weakly interacting particles with masses below the Fermi scale, inaccessible to the LHC experiments, and to study tau neutrino physics. The same proton beam setup can be used later to look for decays of tau-leptons with lepton flavour number non-conservation, [Formula: see text] and to search for weakly-interacting sub-GeV dark matter candidates...
December 2016: Reports on Progress in Physics
https://www.readbyqxmd.com/read/27774608/hemovigilance-in-massachusetts-and-the-adoption-of-statewide-hospital-blood-bank-reporting-using-the-national-healthcare-safety-network
#19
Melissa Cumming, Anthony Osinski, Lynne O'Hearn, Pamela Waksmonski, Michele Herman, Deborah Gordon, Elzbieta Griffiths, Kim Knox, Eileen McHale, Karen Quillen, Jorge Rios, Patricia Pisciotto, Lynne Uhl, Alfred DeMaria, Chester Andrzejewski
A collaboration that grew over time between local hemovigilance stakeholders and the Massachusetts Department of Public Health (MDPH) resulted in the change from a paper-based method of reporting adverse reactions and monthly transfusion activity for regulatory compliance purposes to statewide adoption of electronic reporting via the National Healthcare Safety Network (NHSN). The NHSN is a web-based surveillance system that offers the capacity to capture transfusion-related adverse events, incidents, and monthly transfusion statistics from participating facilities...
October 23, 2016: Transfusion
https://www.readbyqxmd.com/read/27769728/a-12-year-old-girl-with-encephalopathy-and-acute-flaccid-paralysis-a-neuropathological-correlation-and-cohort-review
#20
Young-Min Kim, Anthony Orvedahl, Stephanie Morris, Robert Schmidt, Soe Mar
No abstract text is available yet for this article.
September 8, 2016: Pediatric Neurology
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