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Anthony kim

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https://www.readbyqxmd.com/read/28527969/surgically-managed-clinical-stage-iiia-clinical-n2-lung-cancer-in-the%C3%A2-society-of-thoracic-surgeons-database
#1
Daniel Boffa, Felix G Fernandez, Sunghee Kim, Andrzej Kosinski, Mark W Onaitis, Patricia Cowper, Jeffrey P Jacobs, Cameron D Wright, Joe B Putnam, Anthony P Furnary
BACKGROUND: The role of surgical resection in patients with clinical stage IIIA-N2 positive (cIIIA-N2) lung cancer is controversial, partly because of the variability in short- and long-term outcomes. The objective of this study was to characterize the management of cIIIA-N2 lung cancer in The Society of Thoracic Surgeons General Thoracic Surgery Database (STS-GTSD). METHODS: The STS-GTSD was queried for patients who underwent operations for cIIIA-N2 lung cancer between 2002 and 2012...
May 17, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28522227/promoting-motor-skills-in-low-income-ethnic-children-the-physical-activity-in-linguistically-diverse-communities-paldc-nonrandomized-trial
#2
Anthony D Okely, Louise L Hardy, Marijka Batterham, Phillip Pearson, Kim McKeen, Lauren Puglisi
OBJECTIVES: This study reports the long-term effects of a professional learning program for classroom teachers on fundamental motor skill (FMS) proficiency of primary school students from ethnically diverse backgrounds. DESIGN: A cluster non-randomized trial using a nested cross-sectional design. METHODS: The study was conducted in 8 primary schools located in disadvantaged and culturally diverse areas in Sydney, Australia. The intervention used an action learning framework, with each school developing and implementing an action plan for enhancing the teaching of FMS in their school...
May 8, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28499655/validating-the-thoracic-revised-cardiac-risk-index-following-lung-resection
#3
Daniel C Thomas, Justin D Blasberg, Brian N Arnold, Joshua E Rosen, Michelle C Salazar, Frank C Detterbeck, Daniel J Boffa, Anthony W Kim
BACKGROUND: The Thoracic Revised Cardiac Index (ThRCRI) is a tool that differentiates patients who may proceed to lung resection (classes A or B) from those who should receive additional cardiac evaluation (classes C or D). This study aims to describe the ability of the ThRCRI to stratify patients based on major cardiac complication rates using a large multi-institutional dataset. METHODS: Patients undergoing lobectomy or pneumonectomy were identified in the American College of Surgeons National Surgical Quality Improvement Program dataset from 2005 to 2012...
May 9, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28495746/restored-iron-transport-by-a-small-molecule-promotes-absorption-and-hemoglobinization-in-animals
#4
Anthony S Grillo, Anna M SantaMaria, Martin D Kafina, Alexander G Cioffi, Nicholas C Huston, Murui Han, Young Ah Seo, Yvette Y Yien, Christopher Nardone, Archita V Menon, James Fan, Dillon C Svoboda, Jacob B Anderson, John D Hong, Bruno G Nicolau, Kiran Subedi, Andrew A Gewirth, Marianne Wessling-Resnick, Jonghan Kim, Barry H Paw, Martin D Burke
Multiple human diseases ensue from a hereditary or acquired deficiency of iron-transporting protein function that diminishes transmembrane iron flux in distinct sites and directions. Because other iron-transport proteins remain active, labile iron gradients build up across the corresponding protein-deficient membranes. Here we report that a small-molecule natural product, hinokitiol, can harness such gradients to restore iron transport into, within, and/or out of cells. The same compound promotes gut iron absorption in DMT1-deficient rats and ferroportin-deficient mice, as well as hemoglobinization in DMT1- and mitoferrin-deficient zebrafish...
May 12, 2017: Science
https://www.readbyqxmd.com/read/28489578/inhibiting-translesion-dna-synthesis-as-an-approach-to-combat-drug-resistance-to-dna-damaging-agents
#5
Jung-Suk Choi, Seol Kim, Edward Motea, Anthony Berdis
Anti-cancer agents exert therapeutic effects by damaging DNA. Unfortunately, DNA polymerases can effectively replicate the formed DNA lesions to cause drug resistance and create more aggressive cancers. To understand this process at the cellular level, we developed an artificial nucleoside that visualizes the replication of damaged DNA to identify cells that acquire drug resistance through this mechanism. Visualization is achieved using "click" chemistry to covalently attach azide-containing fluorophores to the ethynyl group present on the nucleoside analog after its incorporation opposite damaged DNA...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28476636/differential-effects-of-immunotherapy-with-antibodies-targeting-%C3%AE-synuclein-oligomers-and-fibrils-in-a-transgenic-model-of-synucleinopathy
#6
Omar El-Agnaf, Cassia Overk, Edward Rockenstein, Michael Mante, Jazmin Florio, Anthony Adame, Nishant Vaikath, Nour Majbour, Seung-Jae Lee, Changyoun Kim, Eliezer Masliah, Robert A Rissman
Disorders with progressive accumulation of α-synuclein (α-syn) are a common cause of dementia and parkinsonism in the aging population. Accumulation and propagation of α-syn play a role in the pathogenesis of these disorders. Previous studies have shown that immunization with antibodies that recognize C-terminus of α-syn reduces the intra-neuronal accumulation of α-syn and related deficits in transgenic models of synucleinopathy. These studies employed antibodies that recognize epitopes within monomeric and aggregated α-syn that were generated through active immunization or administered via passive immunization...
May 2, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28467606/a-prospective-evaluation-of-short-term-dysphagia-after-transoral-robotic-surgery-for-squamous-cell-carcinoma-of-the-oropharynx
#7
William G Albergotti, Jessica Jordan, Keely Anthony, Shira Abberbock, Tamara Wasserman-Wincko, Seungwon Kim, Robert L Ferris, Umamaheswar Duvvuri
BACKGROUND: Transoral robotic surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC) has been associated with improved long-term dysphagia symptomatology compared with chemoradiation. Dysphagia in the perioperative period has been inadequately characterized. The objective of this study was to characterize short-term swallowing outcomes after TORS for OPSCC. METHODS: Patients undergoing TORS for OPSCC were enrolled prospectively. The Eating Assessment Tool 10 (EAT-10) was used as a measure of swallowing dysfunction (score >2) and was administered on postoperative day (POD) 1, 7, and 30...
May 3, 2017: Cancer
https://www.readbyqxmd.com/read/28456393/role-of-adjuvant-treatment-in-esophageal-cancer-with-incidental-pathologic-node-positivity
#8
Sarah J Gao, Henry S Park, Christopher D Corso, Charles E Rutter, Anthony W Kim, Kimberly L Johung
BACKGROUND: The optimal adjuvant treatment for cT1-2 N0 esophageal cancer patients found to have pathologic nodal involvement after an upfront operation is unclear. This study investigated the effects of postoperative chemotherapy and chemoradiation therapy on overall survival in cT1-2 N0 patients with incidental pN(+) disease stratified by margin status. METHODS: We identified cT1-2 N0 M0 esophageal carcinoma patients from 2004 to 2012 from the National Cancer Data Base...
April 26, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28451914/assessment-of-anti-vinculin-and-anti-cytolethal-distending-toxin-b-antibodies-in-subtypes-of-irritable-bowel-syndrome
#9
Ali Rezaie, Sung Chul Park, Walter Morales, Emily Marsh, Anthony Lembo, Jae Hak Kim, Stacy Weitsman, Kathleen S Chua, Gillian M Barlow, Mark Pimentel
BACKGROUND: Antibodies to cytolethal distending toxin B (CdtB) and vinculin are novel biomarkers that rule-in and differentiate irritable bowel syndrome with diarrhea (IBS-D) from other causes of diarrhea and healthy controls. AIM: To determine whether these antibodies can also diagnose and differentiate other IBS subtypes. METHODS: Subjects with IBS-D based on Rome III criteria (n = 2375) were recruited from a large-scale multicenter clinical trial (TARGET 3)...
April 27, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28447321/erratum-to-population-dynamics-among-six-major-groups-of-the-oryza-rufipogon-species-complex-wild-relative-of-cultivated-asian-rice
#10
HyunJung Kim, Janelle Jung, Namrata Singh, Anthony Greenberg, Jeff J Doyle, Wricha Tyagi, Jong-Wook Chung, Jennifer Kimball, Ruaraidh Sackville Hamilton, Susan R McCouch
No abstract text is available yet for this article.
December 2017: Rice
https://www.readbyqxmd.com/read/28442231/case-control-vaccine-effectiveness-studies-preparation-design-and-enrollment-of-cases-and-controls
#11
REVIEW
Jennifer R Verani, Abdullah H Baqui, Claire V Broome, Thomas Cherian, Cheryl Cohen, Jennifer L Farrar, Daniel R Feikin, Michelle J Groome, Rana A Hajjeh, Hope L Johnson, Shabir A Madhi, Kim Mulholland, Katherine L O'Brien, Umesh D Parashar, Manish M Patel, Laura C Rodrigues, Mathuram Santosham, J Anthony Scott, Peter G Smith, Halvor Sommerfelt, Jacqueline E Tate, J Chris Victor, Cynthia G Whitney, Anita K Zaidi, Elizabeth R Zell
Case-control studies are commonly used to evaluate effectiveness of licensed vaccines after deployment in public health programs. Such studies can provide policy-relevant data on vaccine performance under 'real world' conditions, contributing to the evidence base to support and sustain introduction of new vaccines. However, case-control studies do not measure the impact of vaccine introduction on disease at a population level, and are subject to bias and confounding, which may lead to inaccurate results that can misinform policy decisions...
June 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28442230/case-control-vaccine-effectiveness-studies-data-collection-analysis-and-reporting-results
#12
REVIEW
Jennifer R Verani, Abdullah H Baqui, Claire V Broome, Thomas Cherian, Cheryl Cohen, Jennifer L Farrar, Daniel R Feikin, Michelle J Groome, Rana A Hajjeh, Hope L Johnson, Shabir A Madhi, Kim Mulholland, Katherine L O'Brien, Umesh D Parashar, Manish M Patel, Laura C Rodrigues, Mathuram Santosham, J Anthony Scott, Peter G Smith, Halvor Sommerfelt, Jacqueline E Tate, J Chris Victor, Cynthia G Whitney, Anita K Zaidi, Elizabeth R Zell
The case-control methodology is frequently used to evaluate vaccine effectiveness post-licensure. The results of such studies provide important insight into the level of protection afforded by vaccines in a 'real world' context, and are commonly used to guide vaccine policy decisions. However, the potential for bias and confounding are important limitations to this method, and the results of a poorly conducted or incorrectly interpreted case-control study can mislead policies. In 2012, a group of experts met to review recent experience with case-control studies evaluating vaccine effectiveness; we summarize the recommendations of that group regarding best practices for data collection, analysis, and presentation of the results of case-control vaccine effectiveness studies...
June 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28439362/use-of-a-90-minute-admission-window-and-front-fill-system-to-reduce-work-compression-on-a-general-medicine-inpatient-teaching-service
#13
Youngjee Choi, Daniel Kim, Hyemi Chong, Christopher Mallow, Jason Bill, Anthony T Fojo, Melvin Blanchard
BACKGROUND: Duty hour limits have shortened intern shifts without concurrent reductions in workload, creating work compression. Multiple admissions during shortened shifts can result in poor training experience and patient care. OBJECTIVE: To relieve work compression, improve resident satisfaction, and improve duty hour compliance in an academic internal medicine program. METHODS: In 2014, interns on general ward services were allotted 90 minutes per admission from 3 pm to 7 pm, when the rate of admissions was high...
April 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28434648/nivolumab-in-patients-with-advanced-hepatocellular-carcinoma-checkmate-040-an-open-label-non-comparative-phase-1-2-dose-escalation-and-expansion-trial
#14
Anthony B El-Khoueiry, Bruno Sangro, Thomas Yau, Todd S Crocenzi, Masatoshi Kudo, Chiun Hsu, Tae-You Kim, Su-Pin Choo, Jörg Trojan, Theodore H Welling, Tim Meyer, Yoon-Koo Kang, Winnie Yeo, Akhil Chopra, Jeffrey Anderson, Christine Dela Cruz, Lixin Lang, Jaclyn Neely, Hao Tang, Homa B Dastani, Ignacio Melero
BACKGROUND: For patients with advanced hepatocellular carcinoma, sorafenib is the only approved drug worldwide, and outcomes remain poor. We aimed to assess the safety and efficacy of nivolumab, a programmed cell death protein-1 (PD-1) immune checkpoint inhibitor, in patients with advanced hepatocellular carcinoma with or without chronic viral hepatitis. METHODS: We did a phase 1/2, open-label, non-comparative, dose escalation and expansion trial (CheckMate 040) of nivolumab in adults (≥18 years) with histologically confirmed advanced hepatocellular carcinoma with or without hepatitis C or B (HCV or HBV) infection...
April 20, 2017: Lancet
https://www.readbyqxmd.com/read/28432209/a-prospective-observational-cohort-study-of-the-seasonal-dynamics-of-airway-pathogens-in-the-aetiology-of-exacerbations-in-copd
#15
Tom M A Wilkinson, Emmanuel Aris, Simon Bourne, Stuart C Clarke, Mathieu Peeters, Thierry G Pascal, Sonia Schoonbroodt, Andrew C Tuck, Viktoriya Kim, Kristoffer Ostridge, Karl J Staples, Nicholas Williams, Anthony Williams, Stephen Wootton, Jeanne-Marie Devaster
BACKGROUND: The aetiology of acute exacerbations of COPD (AECOPD) is incompletely understood. Understanding the relationship between chronic bacterial airway infection and viral exposure may explain the incidence and seasonality of these events. METHODS: In this prospective, observational cohort study (NCT01360398), patients with COPD aged 40-85 years underwent sputum sampling monthly and at exacerbation for detection of bacteria and viruses. Results are presented for subjects in the full cohort, followed for 1 year...
April 21, 2017: Thorax
https://www.readbyqxmd.com/read/28431710/subacute-pericardial-tamponade-after-sleeve-lower-lobectomy-for-an-extremely-rare-tumor
#16
Michael G Astudillo, Andrew P Dhanasopon, Anthony W Kim
A rare case of subacute cardiac tamponade developed in a 71-year-old patient after a left lower lobe sleeve lobectomy for cancer. The patient was successfully treated by drainage of the pericardial effusion by a pigtail catheter. The exact cause is uncertain, but it appears to include an inflammatory component.
May 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28424202/global-protease-activity-profiling-provides-differential-diagnosis-of-pancreatic-cysts
#17
Sam L Ivry, Jeremy M Sharib, Dana A Dominguez, Nilotpal Roy, Stacy E Hatcher, Michele Yip-Schneider, C Max Schmidt, Randall E Brand, Walter G Park, Matthias Hebrok, Grace Kim, Anthony J O'Donoghue, Kimberly S Kirkwood, Charles S Craik
Pancreatic cysts are estimated to be present 2-3% of the adult population. Unfortunately, current diagnostics do not accurately distinguish benign cysts from those that can progress into invasive cancer. Missregulated pericellular proteolysis is a hallmark of malignancy, and therefore, we used a global approach to discover protease activities that differentiate benign nonmucinous cysts from premalignant mucinous cysts.<br /><br />Experimental Design: We employed an unbiased and global protease profiling approach to discover protease activities in 23 cyst fluid samples...
April 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28413376/ferromagnetic-folded-electrode-composite-as-a-soft-interface-to-the-skin-for-long-term-electrophysiological-recording
#18
Kyung-In Jang, Han Na Jung, Jung Woo Lee, Sheng Xu, Yu Hao Liu, Yinji Ma, Jae-Woong Jeong, Young Min Song, Jeonghyun Kim, Bong Hun Kim, Anthony Banks, Jean Won Kwak, Yiyuan Yang, Dawei Shi, Zijun Wei, Xue Feng, Ungyu Paik, Yonggang Huang, Roozbeh Ghaffari, John A Rogers
This paper introduces a class of ferromagnetic, folded, soft composite material for skin-interfaced electrodes with releasable interfaces to stretchable, wireless electronic measurement systems. These electrodes establish intimate, adhesive contacts to the skin, in dimensionally stable formats compatible with multiple days of continuous operation, with several key advantages over conventional hydrogel based alternatives. The reported studies focus on aspects ranging from ferromagnetic and mechanical behavior of the materials systems, to electrical properties associated with their skin interface, to system-level integration for advanced electrophysiological monitoring applications...
October 25, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/28411262/aspirin-s-benefits-were-previously-underestimated-and-are-primarily-accrued-in-the-acute-setting
#19
REVIEW
Pierre Amarenco, Anthony S Kim
No abstract text is available yet for this article.
April 14, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28393386/maternal-depressive-symptoms-perceived-stress-and-fetal-growth
#20
William A Grobman, Deborah A Wing, Paul Albert, Sungduk Kim, Jagteshwar Grewal, Constance Guille, Roger Newman, Edward K Chien, John Owen, Mary E D'Alton, Ronald Wapner, Anthony Sciscione, Katherine L Grantz
OBJECTIVES: To determine whether longitudinal fetal growth is altered among pregnant women reporting greater perceived stress or more symptoms of depression. METHODS: This analysis was based on a multicenter longitudinal study of fetal growth. Women were screened at gestational ages of 8 weeks to 13 weeks 6 days for low-risk status and underwent serial sonographic examinations. At each study visit during pregnancy, women were asked to complete the Cohen Perceived Stress Scale (PSS) and Edinburgh Postpartum Depression Survey (EPDS)...
April 10, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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