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https://www.readbyqxmd.com/read/28056112/association-of-delayed-adjuvant-chemotherapy-with-survival-after-lung-cancer-surgery
#1
Michelle C Salazar, Joshua E Rosen, Zuoheng Wang, Brian N Arnold, Daniel C Thomas, Roy S Herbst, Anthony W Kim, Frank C Detterbeck, Justin D Blasberg, Daniel J Boffa
Importance: Adjuvant chemotherapy offers a survival benefit to a number of staging scenarios in non-small-cell lung cancer. Variable recovery from lung cancer surgery may delay a patient's ability to tolerate adjuvant chemotherapy, yet the urgency of chemotherapy initiation is unclear. Objective: To assess differences in survival according to the time interval between non-small-cell lung cancer resection and the initiation of postoperative chemotherapy to determine the association between adjuvant treatment timing and efficacy...
January 5, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28043473/estimating-the-annual-incremental-cost-of-several-complications-following-pulmonary-lobectomy
#2
Oliver K Jawitz, Daniel J Boffa, Frank C Detterbeck, Zuoheng Wang, Anthony W Kim
Determine the incremental increase in cost as well as length of hospital stay associated with several major complications following pulmonary lobectomy using a large national dataset. A retrospective cohort analysis of the 2012 National Inpatient Sample, Healthcare Cost and Utilization Project database was performed. Demographic and clinical data on patients ≥18 years having undergone an open or VATS lobectomy were included in the analysis. The median increase in cost and length of stay associated with relevant major complications were determined using a multivariable quantile regression model...
July 2016: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28024700/defining-outcomes-of-patients-with-clinical-stage-i-small-cell-lung-cancer-upstaged-at-surgery
#3
Daniel C Thomas, Brian N Arnold, Joshua E Rosen, Michelle C Salazar, Justin D Blasberg, Frank C Detterbeck, Daniel J Boffa, Anthony W Kim
BACKGROUND: A proportion of patients with clinical stage I small cell lung cancer (SCLC) will be upstaged following surgical resection. The existing data regarding the management of upstaged SCLC patients and guidelines for their treatment remains sparse. The primary objective was to describe the impact of pathologic upstaging following surgical resection. METHODS: The National Cancer Database was queried for patients with clinical stage I SCLC (cT1-2a,N0,M0) who underwent resection with curative intent followed by adjuvant therapy, excluding patients who underwent surgery alone...
January 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27890561/role-of-adjuvant-therapy-for-node-negative-lung-cancer-invading-the-chest-wall
#4
Sarah J Gao, Christopher D Corso, Justin D Blasberg, Frank C Detterbeck, Daniel J Boffa, Roy H Decker, Anthony W Kim
INTRODUCTION: The present study investigated the effect of adjuvant chemotherapy and radiation on survival among patients undergoing chest wall resection for T3N0 non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Patients with T3N0 NSCLC who underwent chest wall resection were identified in the National Cancer Data Base in 2004 to 2012. The cohort was divided into patients who had received adjuvant chemotherapy, radiation therapy, chemoradiation therapy, or no adjuvant treatment...
October 17, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27876674/thymic-carcinoma-management-patterns-among-international-thymic-malignancy-interest-group-itmig-physicians-with-consensus-from-the-thymic-carcinoma-working-group
#5
Annemarie Shepherd, Gregory Riely, Frank Detterbeck, Charles B Simone, Usman Ahmad, James Huang, Robert Korst, Arun Rajan, Andreas Rimner
INTRODUCTION: Thymic carcinomas are rare epithelial malignancies with limited data to guide management. METHODS: To identify areas of agreement and variability in current clinical practice, a 16-question electronic survey was given to members of the International Thymic Malignancy Interest Group (ITMIG). Areas of controversy were discussed with the Thymic Carcinoma Working Group and consensus was achieved, as described. RESULTS: A total of 100 ITMIG members responded...
November 19, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27812721/assessment-of-facial-soft-tissue-profiles-based-on-lateral-photographs-versus-three-dimensional-face-scans
#6
Martin Fink, Ursula Hirschfelder, Veronika Hirschinger, Matthias Schmid, Caroline Spitzl, Andreas Detterbeck, Elisabeth Hofmann
OBJECTIVES: The purpose of this study was to compare two-dimensional (2D) lateral photographs versus three-dimensional (3D) face scans in analyzing facial profiles using Schwarz's concept of the jaw profile field (JPF) in its original 2D and in a modified 3D version. In addition, the distribution of the facial profile types described by Schwarz were examined. MATERIALS AND METHODS: Of 75 adult volunteers recruited specifically for this study, we obtained both photographs (Nikon D 300S; Nikon, Düsseldorf, Germany) and scans (FaceSCAN(3D) Scientific Photolab 60 Hz; 3D-Shape, Erlangen, Germany) in a standardized setting...
November 3, 2016: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/27780786/the-8-th-edition-lung-cancer-stage-classification
#7
REVIEW
Frank C Detterbeck, Daniel J Boffa, Anthony W Kim, Lynn T Tanoue
Stage classification provides a nomenclature about the anatomic extent of a cancer; a consistent language provides the ability to communicate about a specific patient and about cohorts of patients in clinical studies. This paper summarizes the 8(th) edition of lung cancer stage classification, which is the worldwide standard as of January 1, 2017. This revision is based on a large global database, a sophisticated analysis, extensive internal validation as well as multiple assessments confirming generalizability...
October 22, 2016: Chest
https://www.readbyqxmd.com/read/27735079/dataset-for-reporting-of-thymic-epithelial-tumours-recommendations-from-the-international-collaboration-on-cancer-reporting-iccr
#8
Andrew G Nicholson, Frank Detterbeck, Alexander Marx, Anja C Roden, Alberto M Marchevsky, Kiyoshi Mukai, Gang Chen, Mirella Marino, Michael A den Bakker, Woo-Ick Yang, Meagan Judge, Lynn Hirschowitz
AIMS: The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organisation formed by the Royal Colleges of Pathologists of Australasia and the United Kingdom, the College of American Pathologists, the Canadian Association of Pathologists-Association Canadienne des Pathologists (CAP-ACP) in association with the Canadian Partnership Against Cancer (CPAC), and the European Society of Pathology (ESP). Its goal is to produce standardised, internationally agreed, evidence-based datasets for use throughout the world...
October 13, 2016: Histopathology
https://www.readbyqxmd.com/read/27720827/timing-of-surgery-after-neoadjuvant-chemoradiation-in-locally-advanced-non-small-cell-lung-cancer
#9
Sarah J Gao, Christopher D Corso, Elyn H Wang, Justin D Blasberg, Frank C Detterbeck, Daniel J Boffa, Roy H Decker, Anthony W Kim
INTRODUCTION: A subset of patients with potentially resectable clinical stage IIIA NSCLC are managed with trimodality therapy. However, little data exist to guide the timing of surgery after neoadjuvant therapy. This study examined whether the time interval between neoadjuvant chemoradiation (NCRT) and surgical resection affects overall survival. METHODS: Patients with clinical stage IIIA disease (T1-3 N2) NSCLC who underwent NCRT were identified in the National Cancer Data Base (NCDB) between 2004 and 2012 and categorized on the basis of the interval between chemoradiation and surgery (0 to ≤3, >3 to ≤6, >6 to ≤9, and >9 to ≤12 weeks)...
October 5, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27687847/hospital-volume-and-outcomes-of-robot-assisted-lobectomies
#10
Lise N Tchouta, Henry S Park, Daniel J Boffa, Justin D Blasberg, Frank C Detterbeck, Anthony W Kim
BACKGROUND: The positive impact of hospital operative volume on outcomes following video-assisted thoracoscopic surgery has been established. The goal of this study was to determine whether or not this volume-outcome relationship translates to robotic-assisted thoracoscopic surgery (RobATS) lobectomy. METHODS: Patients who underwent RobATS lobectomy were identified between 2008 and 2013 in the Healthcare Cost and Utilization Project National Inpatient Sample (HCUP-NIS) database...
September 26, 2016: Chest
https://www.readbyqxmd.com/read/27675990/effects-of-adjuvant-therapy-on-survival-in-t3n0-non-small-cell-lung-cancer-invading-the-chest-wall
#11
S Gao, C D Corso, F C Detterbeck, D Boffa, R H Decker, A W Kim
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675547/indications-for-invasive-mediastinal-staging-in-patients-with-early-non-small-cell-lung-cancer-staged-with-positron-emission-tomography-computed-tomography
#12
S Gao, A W Kim, F C Detterbeck, D Boffa, J Puchalski, R H Decker
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674777/timing-of-surgery-after-neoadjuvant-chemoradiation-in-clinical-stage-iiia-non-small-cell-lung-cancer-with-mediastinal-nodal-involvement
#13
S Gao, C D Corso, E H Wang, J Blasberg, D Boffa, F C Detterbeck, A W Kim
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27619638/the-impact-of-chart-on-the-science-of-thymic-malignancies
#14
EDITORIAL
Frank Detterbeck
No abstract text is available yet for this article.
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27565401/selective-application-of-lobe-specific-node-dissection
#15
EDITORIAL
Frank C Detterbeck
No abstract text is available yet for this article.
September 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27564681/length-of-stay-from-the-hospital-perspective-practice-of-early-discharge-is-not-associated-with-increased-readmission-risk-after-lung-cancer-surgery
#16
Joshua E Rosen, Michelle C Salazar, Kumar Dharmarajan, Anthony W Kim, Frank C Detterbeck, Daniel J Boffa
OBJECTIVE: To determine if hospitals that routinely discharge patients early after lobectomy have increased readmissions. BACKGROUND: Hospitals are increasingly motivated to reduce length of stay (LOS) after lung cancer surgery, yet it is unclear if a routine of early discharge is associated with increased readmissions. The relationship between hospital discharge practices and readmission rates is therefore of tremendous clinical and financial importance. METHODS: The National Cancer Database was queried for patients undergoing lobectomy for lung cancer from 2004 to 2013 at Commission on Cancer-accredited hospitals, which performed at least 25 lobectomies in a 2-year period...
August 25, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27502792/landmarks-of-the-frankfort-horizontal-plane-reliability-in-a-three-dimensional-cartesian-coordinate-system
#17
Elisabeth Hofmann, Rolf Fimmers, Matthias Schmid, Ursula Hirschfelder, Andreas Detterbeck, Klaus Hertrich
OBJECTIVES: The goal was to investigate whether the three-dimensional (3D) reliability of the landmarks defining the Frankfort horizontal plane (FH) can be enhanced by reducing variance with the help of nearby anatomical structures. METHODS: Twenty multislice computed tomography (MSCT) datasets of evidently symmetrical patients (11 female and 9 male patients, 6.1-16 years old) were selected from 695 datasets archived at our department. In the 3D reconstructions, we located the anthropometric landmarks orbitale and porion, then these were modified with the help of frontomalare temporale, radiculare and the most anterior border of the left and right external acoustic pore...
September 2016: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/27458143/the-differential-impact-of-preoperative-comorbidity-on-perioperative-outcomes-following-thoracoscopic-and-open-lobectomies
#18
Oliver K Jawitz, Zuoheng Wang, Daniel J Boffa, Frank C Detterbeck, Justin D Blasberg, Anthony W Kim
OBJECTIVES: Video-assisted thoracoscopic surgery (VATS) lobectomy is quickly becoming the standard of care for many patients with early-stage non-small-cell lung cancer (NSCLC) and benign lung conditions. There is a lack of published data defining the differential impact of preoperative patient comorbidity on outcomes following VATS and OPEN lobectomies, which would be beneficial for procedure selection and clinical decision-making. METHODS: A retrospective analysis of the 2008-2011 Nationwide Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP) database was performed...
July 25, 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/27448762/the-iaslc-lung-cancer-staging-project-methodology-and-validation-used-in-the-development-of-proposals-for-revision-of-the-stage-classification-of-nsclc-in-the-forthcoming-eighth-edition-of-the-tnm-classification-of-lung-cancer
#19
Frank C Detterbeck, Kari Chansky, Patti Groome, Vanessa Bolejack, John Crowley, Lynn Shemanski, Catherine Kennedy, Mark Krasnik, Michael Peake, Ramón Rami-Porta
INTRODUCTION: Stage classification provides a consistent language to describe the anatomic extent of disease and is therefore a critical tool in caring for patients. The Staging and Prognostic Factors Committee of the International Association for the Study of Lung Cancer developed proposals for revision of the classification of lung cancer for the eighth edition of the tumor, node, and metastasis (TNM) classification, which takes effect in 2017. METHODS: An international database of 94,708 patients with lung cancer diagnosed in 1999-2010 was assembled...
September 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27365182/determination-of-the-mesio-distal-tooth-width-via-3d-imaging-techniques-with-and-without-ionizing-radiation-cbct-msct-and-%C3%A2%C2%B5ct-versus-mri
#20
Andreas Detterbeck, Michael Hofmeister, Daniel Haddad, Daniel Weber, Matthias Schmid, Astrid Hölzing, Simon Zabler, Elisabeth Hofmann, Karl-Heinz Hiller, Peter Jakob, Jens Engel, Jochen Hiller, Ursula Hirschfelder
OBJECTIVE: The purpose of this study was to estimate the feasibility and accuracy of mesio-distal width measurements with magnetic resonance imaging (MRI) in comparison to conventional 3D imaging techniques [multi-slice CT (MSCT), cone-beam CT (CBCT), and µCT]. The measured values of the tooth widths were compared to each other to estimate the amount of radiation necessary to enable orthodontic diagnostics. MATERIAL AND METHODS: Two pig skulls were measured with MSCT, CBCT, µCT, and MRI...
June 30, 2016: European Journal of Orthodontics
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