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Frank C Detterbeck
No abstract text is available yet for this article.
March 2018: Journal of Thoracic Disease
Alexander S Chiu, Brian N Arnold, Jessica R Hoag, Jeph Herrin, Clara H Kim, Michelle C Salazar, Andres F Monsalve, Raymond A Jean, Justin D Blasberg, Frank C Detterbeck, Cary P Gross, Daniel J Boffa
OBJECTIVE: To estimate the potential mortality reduction if patients chose the safest hospitals for complex cancer surgery. BACKGROUND: Mortality after complex oncologic surgery is highly variable across hospitals, and directing patients away from unsafe hospitals could potentially improve survivorship. Hospital quality measures are becoming increasingly accessible at a time when patients are more engaged in choosing providers. It is currently unclear what information to share with patients to maximally capitalize on patient-centered realignment...
April 24, 2018: Annals of Surgery
Frank C Detterbeck
No abstract text is available yet for this article.
February 2018: Journal of Thoracic Disease
Brian N Arnold, Daniel C Thomas, Raja Narayan, Justin D Blasberg, Frank C Detterbeck, Daniel J Boffa, Anthony W Kim
BACKGROUND: Robotic-assisted thoracoscopic surgery (RobATS) lobectomy is becoming more common for the treatment of lung cancer. As with any relatively new technology, there is the assumption that greater experience leads to greater proficiency. The objective of this study was to analyze outcomes of patients undergoing RobATS lobectomy as hospitals gain experience and to describe outcomes after conversion to open procedures. STUDY DESIGN: The National Cancer DataBase (NCDB) was used to analyze robotic lobectomies for lung cancer from 2010-2014...
March 21, 2018: Journal of the American College of Surgeons
Makoto Mori, Frank C Detterbeck
Primary carcinoma of the trachea is an exceeding rare entity. We present a case of radiation-induced primary squamous cell carcinoma of the trachea in a young woman. The case highlights a diagnostic challenge of this atypical disease entity.
March 15, 2018: General Thoracic and Cardiovascular Surgery
Daniel C Thomas, Brian N Arnold, Jessica R Hoag, Michelle C Salazar, Frank C Detterbeck, Daniel J Boffa, Anthony W Kim, Justin D Blasberg
BACKGROUND: Few studies have examined the risk factors for and timing of venous thromboembolism (VTE) in patients undergoing surgical procedures for lung cancer, and there are limited data to formulate guidelines for extended VTE prophylaxis after hospital discharge. This study sought to identify risk factors for postdischarge VTE after lung resection. METHODS: Patients undergoing anatomic resection for lung cancer were identified in the National Surgical Quality Improvement Program database from 2005 to 2015...
May 2018: Annals of Thoracic Surgery
Andrew G Nicholson, Ming S Tsao, William D Travis, Deepa T Patil, Francoise Galateau-Salle, Mirella Marino, Sanja Dacic, Mary Beth Beasley, Kelly J Butnor, Yasushi Yatabe, Harvey I Pass, Valerie W Rusch, Frank C Detterbeck, Hisao Asamura, Thomas W Rice, Ramon Rami-Porta
Context The Staging and Prognostic Factors Committee of the International Association for the Study of Lung Cancer, in conjunction with the International Mesothelioma Interest Group, the International Thymic Malignancy Interest Group, and the Worldwide Esophageal Cancer Collaboration, developed proposals for the 8th edition of their respective tumor, node, metastasis (TNM) staging classification systems. Objective To review these changes and discuss issues for the reporting pathologist. Data Sources Proposals were based on international databases of lung (N = 94 708), with an external validation using the US National Cancer Database; mesothelioma (N = 3519); thymic epithelial tumors (10 808); and epithelial cancers of the esophagus and esophagogastric junction (N = 22 654)...
May 2018: Archives of Pathology & Laboratory Medicine
Peter J Mazzone, Gerard A Silvestri, Sheena Patel, Jeffrey P Kanne, Linda S Kinsinger, Renda Soylemez Wiener, Guy Soo Hoo, Frank C Detterbeck
BACKGROUND: Low-dose chest CT screening for lung cancer has become a standard of care in the United States in the past few years, in large part due to the results of the National Lung Screening Trial. The benefit and harms of low-dose chest CT screening differ in both frequency and magnitude. The translation of a favorable balance of benefit and harms into practice can be difficult. Here, we update the evidence base for the benefit, harms, and implementation of low radiation dose chest CT screening...
April 2018: Chest
Sukhmani K Padda, Xiaopan Yao, Alberto Antonicelli, Jonathan W Riess, Yue Shang, Joseph B Shrager, Robert Korst, Frank Detterbeck, James Huang, Bryan M Burt, Heather A Wakelee, Sunil S Badve
INTRODUCTION: Thymic epithelial tumors (TETs) are associated with paraneoplastic/autoimmune (PN/AI) syndromes. Myasthenia gravis is the most common PN/AI syndrome associated with TETs. METHODS: The International Thymic Malignancy Interest Group retrospective database was examined to determine (1) baseline and treatment characteristics associated with PN/AI syndromes and (2) the prognostic role of PN/AI syndromes for patients with TETs. The competing risks model was used to estimate cumulative incidence of recurrence (CIR) and the Kaplan-Meier method was used to calculate overall survival (OS)...
March 2018: Journal of Thoracic Oncology
Andrew G Nicholson, Kathleen Torkko, Patrizia Viola, Edwina Duhig, Kim Geisinger, Alain C Borczuk, Kenzo Hiroshima, Ming S Tsao, Arne Warth, Sylvie Lantuejoul, Prudence A Russell, Erik Thunnissen, Alberto Marchevsky, Mari Mino-Kenudson, Mary Beth Beasley, Johan Botling, Sanja Dacic, Yasushi Yatabe, Masayuki Noguchi, William D Travis, Keith Kerr, Fred R Hirsch, Lucian R Chirieac, Ignacio I Wistuba, Andre Moreira, Jin-Haeng Chung, Teh Ying Chou, Lukas Bubendorf, Gang Chen, Giuseppe Pelosi, Claudia Poleri, Frank C Detterbeck, Wilbur A Franklin
Multiple tumor nodules are seen with increasing frequency in clinical practice. On the basis of the 2015 WHO classification of lung tumors, we assessed the reproducibility of the comprehensive histologic assessment to distinguish second primary lung cancers (SPLCs) from intrapulmonary metastases (IPMs), looking for the most distinctive histologic features. An international panel of lung pathologists reviewed a scanned sequential cohort of 126 tumors from 48 patients and recorded an agreed set of histologic features, including tumor typing and predominant pattern of adenocarcinoma, thereby opining whether the case was SPLC, IPM, or a combination thereof...
February 2018: Journal of Thoracic Oncology
Hasmeena Kathuria, Frank C Detterbeck, Joelle T Fathi, Kathleen Fennig, Michael K Gould, Denise G Jolicoeur, Stephanie R Land, Greta M Massetti, Peter J Mazzone, Gerard A Silvestri, Christopher G Slatore, Robert A Smith, Anil Vachani, Steven B Zeliadt, Renda Soylemez Wiener
RATIONALE: Smoking cessation counseling in conjunction with low-dose computed tomography (LDCT) lung cancer screening is recommended in multiple clinical practice guidelines. The best approach for integrating effective smoking cessation interventions within this setting is unknown. OBJECTIVES: To summarize evidence, identify research gaps, prioritize topics for future research, and propose standardized tools for use in conducting research on smoking cessation interventions within the LDCT lung cancer screening setting...
November 1, 2017: American Journal of Respiratory and Critical Care Medicine
Andrew P Dhanasopon, Michelle C Salazar, Jessica R Hoag, Joshua E Rosen, Anthony W Kim, Frank C Detterbeck, Justin D Blasberg, Daniel J Boffa
BACKGROUND: Lung cancer patients rely on survival estimates to weigh risks and benefits of treatment. However, pneumonectomy-requiring lung cancer may have inherent oncologic or physiologic survival implications not captured by the current stage classification. Stage-specific survival was evaluated to refine survival expectations for patients with pneumonectomy-requiring disease. METHODS: The National Cancer Database was queried for treatment-naive patients who underwent lobectomy or pneumonectomy for stage I to III non-small cell lung cancer between 2004 and 2013...
December 2017: Annals of Thoracic Surgery
Frank C Detterbeck
No abstract text is available yet for this article.
January 2018: Journal of Thoracic and Cardiovascular Surgery
Robert J Korst, Sumudinie Fernando, Ann Christine Catlin, John R Rutledge, Nicolas Girard, James Huang, Frank Detterbeck
BACKGROUND: Positron emission tomography may have a role in the pretreatment workup of patients with thymic malignancies. This study was undertaken to determine the utility of the maximum standardized uptake value (SUVmax ) in predicting histologic type and tumor stage in a large cohort of thymic epithelial tumors. METHODS: The large, multiinstitutional, prospective database of The International Thymic Malignancy Interest Group (ITMIG) was queried for the use of positron emission tomography in the pretreatment workup of patients with thymic tumors...
December 2017: Annals of Thoracic Surgery
Frank C Detterbeck, Michael K Gould, Sandra Zelman Lewis, Sheena Patel
Clinical practice involves making many treatment decisions for which only limited formal evidence exists. While the methodology of evidence-based medicine (EBM) has evolved tremendously, there is a need to better characterize lower-level evidence. This should enhance the ability to appropriately weigh the evidence against other considerations, and counter the temptation to think it is more robust than it actually is. A framework to categorize lower-level evidence is proposed, consisting of nonrandomized comparisons, extrapolation using indirect evidence, rationale, and clinical experience (ie, an accumulated general impression)...
February 2018: Chest
Daniel C Thomas, Brian N Arnold, Joshua E Rosen, Michelle C Salazar, Frank C Detterbeck, Justin D Blasberg, Daniel J Boffa, Anthony W Kim
BACKGROUND: Previous literature suggests that patients with non-small cell lung cancer (NSCLC) and unsuspected N2 disease (cN0, pN2) represent a distinct subgroup associated with improved overall survival compared to patients with N2 disease identified prior to resection (cN2, pN2). METHODS: Retrospective analysis of the National Cancer Database of patients from 2004 to 2011 with cN0 and cN2 status found to be pathologic stage III-N2 NSCLC after surgical resection...
January 2018: World Journal of Surgery
Brian N Arnold, Daniel C Thomas, Joshua E Rosen, Michelle C Salazar, Frank C Detterbeck, Justin D Blasberg, Daniel J Boffa, Anthony W Kim
BACKGROUND: Stage I non-small-cell lung cancer is potentially curable, yet older patients undergo treatment at lower rates than younger patients. This analysis sought to describe the treatment outcomes of nonagenarians with stage I non-small-cell lung cancer to better guide treatment decisions in this population. METHODS: The National Cancer DataBase was queried for patients age ≥90 years old with stage I non-small-cell lung cancer (tumors ≤4 cm). Patients were divided into 3 groups: local therapy, other therapy, or no treatment...
September 2017: Surgery
S Gao, A Kim, J Puchalski, K Bramley, F C Detterbeck, D Boffa, R H Decker
No abstract text is available yet for this article.
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
Ross A Soo, Emily C A Stone, K Michael Cummings, James R Jett, John K Field, Harry J M Groen, James L Mulshine, Yasushi Yatabe, Lukas Bubendorf, Sanja Dacic, Ramon Rami-Porta, Frank C Detterbeck, Eric Lim, Hisao Asamura, Jessica Donington, Heather A Wakelee, Yi-Long Wu, Kristin Higgins, Suresh Senan, Benjamin Solomon, Dong-Wan Kim, Melissa Johnson, James C H Yang, Lecia V Sequist, Alice T Shaw, Myung-Ju Ahn, Daniel B Costa, Jyoti D Patel, Leora Horn, Scott Gettinger, Solange Peters, Murry W Wynes, Corinne Faivre-Finn, Charles M Rudin, Anne Tsao, Paul Baas, Ronan J Kelly, Natasha B Leighl, Giorgio V Scagliotti, David R Gandara, Fred R Hirsch, David R Spigel
Lung cancer care is rapidly changing with advances in genomic testing, the development of next-generation targeted kinase inhibitors, and the continued broad study of immunotherapy in new settings and potential combinations. The International Association for the Study of Lung Cancer and the Journal of Thoracic Oncology publish this annual update to help readers keep pace with these important developments. Experts in thoracic cancer and care provide focused updates across multiple areas, including prevention and early detection, molecular diagnostics, pathology and staging, surgery, adjuvant therapy, radiotherapy, molecular targeted therapy, and immunotherapy for NSCLC, SCLC, and mesothelioma...
August 2017: Journal of Thoracic Oncology
Sarah J Gao, Anthony W Kim, Jonathan T Puchalski, Kyle Bramley, Frank C Detterbeck, Daniel J Boffa, Roy H Decker
PURPOSE/OBJECTIVE(S): Appropriate use of invasive mediastinal staging in patients with clinically node-negative NSCLC staged by PET-CT is critical in selecting patients for curative-intent therapy such as surgery or SBRT, but little data exists to guide this decision-making. We examined a large population of patients with clinical stage I NSCLC referred for mediastinoscopy or EBUS to find risk factors for occult N2 lymph nodes and determine which patients benefit from invasive staging...
July 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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