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Andrew G Nicholson, Frank Detterbeck, Alexander Marx, Anja C Roden, Alberto M Marchevsky, Kiyoshi Mukai, Gang Chen, Mirella Marino, Michael A den Bakker, Woo-Ick Yang, Meagan Judge, Lynn Hirschowitz
AIMS: The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organisation formed by the Royal Colleges of Pathologists of Australasia and the United Kingdom, the College of American Pathologists, the Canadian Association of Pathologists-Association Canadienne des Pathologists (CAP-ACP) in association with the Canadian Partnership Against Cancer (CPAC), and the European Society of Pathology (ESP). Its goal is to produce standardised, internationally agreed, evidence-based datasets for use throughout the world...
October 13, 2016: Histopathology
Sarah J Gao, Christopher D Corso, Elyn H Wang, Justin D Blasberg, Frank C Detterbeck, Daniel J Boffa, Roy H Decker, Anthony W Kim
INTRODUCTION: A subset of patients with potentially resectable clinical stage IIIA non-small cell lung cancer (NSCLC) are managed with trimodality therapy. However, little data exist to guide the timing of surgery after neoadjuvant therapy. This study examined whether the time interval between neoadjuvant chemoradiation (NCRT) and surgical resection impacts overall survival. METHODS: Clinical stage IIIA disease (T1-3 N2) NSCLC patients who underwent neoadjuvant chemoradiation therapy were identified in the National Cancer Data Base (NCDB) between 2004-2012 and categorized based on the interval between chemoradiation and surgery (0 to ≤3, 3 to ≤6, 6 to ≤9, and 9 to ≤12 weeks)...
October 5, 2016: Journal of Thoracic Oncology
Lise N Tchouta, Henry S Park, Daniel J Boffa, Justin D Blasberg, Frank C Detterbeck, Anthony W Kim
BACKGROUND: The positive impact of hospital operative volume on outcomes following video-assisted thoracoscopic surgery has been established. The goal of this study was to determine whether or not this volume-outcome relationship translates to robotic-assisted thoracoscopic surgery (RobATS) lobectomy. METHODS: Patients who underwent RobATS lobectomy were identified between 2008 and 2013 in the Healthcare Cost and Utilization Project National Inpatient Sample (HCUP-NIS) database...
September 26, 2016: Chest
S Gao, C D Corso, F C Detterbeck, D Boffa, R H Decker, A W Kim
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
S Gao, A W Kim, F C Detterbeck, D Boffa, J Puchalski, R H Decker
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
S Gao, C D Corso, E H Wang, J Blasberg, D Boffa, F C Detterbeck, A W Kim
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Frank Detterbeck
No abstract text is available yet for this article.
August 2016: Journal of Thoracic Disease
Frank C Detterbeck
No abstract text is available yet for this article.
September 2016: Journal of Thoracic Oncology
Joshua E Rosen, Michelle C Salazar, Kumar Dharmarajan, Anthony W Kim, Frank C Detterbeck, Daniel J Boffa
OBJECTIVE: To determine if hospitals that routinely discharge patients early after lobectomy have increased readmissions. BACKGROUND: Hospitals are increasingly motivated to reduce length of stay (LOS) after lung cancer surgery, yet it is unclear if a routine of early discharge is associated with increased readmissions. The relationship between hospital discharge practices and readmission rates is therefore of tremendous clinical and financial importance. METHODS: The National Cancer Database was queried for patients undergoing lobectomy for lung cancer from 2004 to 2013 at Commission on Cancer-accredited hospitals, which performed at least 25 lobectomies in a 2-year period...
August 25, 2016: Annals of Surgery
Elisabeth Hofmann, Rolf Fimmers, Matthias Schmid, Ursula Hirschfelder, Andreas Detterbeck, Klaus Hertrich
OBJECTIVES: The goal was to investigate whether the three-dimensional (3D) reliability of the landmarks defining the Frankfort horizontal plane (FH) can be enhanced by reducing variance with the help of nearby anatomical structures. METHODS: Twenty multislice computed tomography (MSCT) datasets of evidently symmetrical patients (11 female and 9 male patients, 6.1-16 years old) were selected from 695 datasets archived at our department. In the 3D reconstructions, we located the anthropometric landmarks orbitale and porion, then these were modified with the help of frontomalare temporale, radiculare and the most anterior border of the left and right external acoustic pore...
September 2016: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
Oliver K Jawitz, Zuoheng Wang, Daniel J Boffa, Frank C Detterbeck, Justin D Blasberg, Anthony W Kim
OBJECTIVES: Video-assisted thoracoscopic surgery (VATS) lobectomy is quickly becoming the standard of care for many patients with early-stage non-small-cell lung cancer (NSCLC) and benign lung conditions. There is a lack of published data defining the differential impact of preoperative patient comorbidity on outcomes following VATS and OPEN lobectomies, which would be beneficial for procedure selection and clinical decision-making. METHODS: A retrospective analysis of the 2008-2011 Nationwide Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP) database was performed...
July 25, 2016: European Journal of Cardio-thoracic Surgery
Frank C Detterbeck, Kari Chansky, Patti Groome, Vanessa Bolejack, John Crowley, Lynn Shemanski, Catherine Kennedy, Mark Krasnik, Michael Peake, Ramón Rami-Porta
INTRODUCTION: Stage classification provides a consistent language to describe the anatomic extent of disease and is therefore a critical tool in caring for patients. The Staging and Prognostic Factors Committee of the International Association for the Study of Lung Cancer developed proposals for revision of the classification of lung cancer for the eighth edition of the tumor, node, and metastasis (TNM) classification, which takes effect in 2017. METHODS: An international database of 94,708 patients with lung cancer diagnosed in 1999-2010 was assembled...
September 2016: Journal of Thoracic Oncology
Andreas Detterbeck, Michael Hofmeister, Daniel Haddad, Daniel Weber, Matthias Schmid, Astrid Hölzing, Simon Zabler, Elisabeth Hofmann, Karl-Heinz Hiller, Peter Jakob, Jens Engel, Jochen Hiller, Ursula Hirschfelder
OBJECTIVE: The purpose of this study was to estimate the feasibility and accuracy of mesio-distal width measurements with magnetic resonance imaging (MRI) in comparison to conventional 3D imaging techniques [multi-slice CT (MSCT), cone-beam CT (CBCT), and µCT]. The measured values of the tooth widths were compared to each other to estimate the amount of radiation necessary to enable orthodontic diagnostics. MATERIAL AND METHODS: Two pig skulls were measured with MSCT, CBCT, µCT, and MRI...
June 30, 2016: European Journal of Orthodontics
Andreas Rimner, Xiaopan Yao, James Huang, Alberto Antonicelli, Usman Ahmad, Robert J Korst, Frank Detterbeck, Daniel R Gomez
OBJECTIVES: The aim of this study was to determine whether postoperative radiation therapy (PORT) is associated with an overall survival (OS) benefit in patients with completely resected Masaoka or Masaoka-Koga stage II and III thymoma. METHODS: All patients with completely resected (R0) stage II or III thymoma were identified in a large database of the International Thymic Malignancy Interest Group. Clinical, pathologic, treatment, and follow-up information were extracted...
October 2016: Journal of Thoracic Oncology
Joshua E Rosen, Michelle C Salazar, Zuoheng Wang, James B Yu, Roy H Decker, Anthony W Kim, Frank C Detterbeck, Daniel J Boffa
OBJECTIVES: Stereotactic body radiotherapy is an effective treatment for patients with early-stage non-small cell lung cancer who are not healthy enough to undergo surgery; however, the relative efficacy versus surgery in healthy patients is unknown. The National Cancer Database contains information on patient health and eligibility for surgery, allowing the long-term survival associated with lobectomy and stereotactic body radiotherapy to be compared in healthy patients with clinical stage I disease...
July 2016: Journal of Thoracic and Cardiovascular Surgery
Amelie Detterbeck, Paula Pongrac, Stefan Rensch, Stefan Reuscher, Matic Pečovnik, Primož Vavpetič, Primož Pelicon, Stefan Holzheu, Ute Krämer, Stephan Clemens
Genetic biofortification requires knowledge on natural variation and the underlying mechanisms of micronutrient accumulation. We therefore studied diversity in grain micronutrient concentrations and spatial distribution in barley (Hordeum vulgare), a genetically tractable model cereal and an important crop with widespread cultivation. We assembled a diverse collection of barley cultivars and landraces and analysed grain micronutrient profiles in genebank material and after three independent cultivations. Lines with contrasting grain zinc (Zn) accumulation were selected for in-depth analysis of micronutrient distribution within the grain by micro-proton-induced X-ray emission (μ-PIXE)...
September 2016: New Phytologist
Muhammad Ansar Farooq, Amelie Detterbeck, Stephan Clemens, Karl-Josef Dietz
Silicon (Si) modulates tolerance to abiotic stresses, but little is known about the reversibility of stress effects by supplementing previously stressed plants with Si. This is surprising since recovery experiments might allow mechanisms of Si-mediated amelioration to be addressed. Rice was exposed to 10 µM CdCl2 for 4 d in hydroponics, followed by 0.6mM Si(OH)4 supplementation for 4 d. Si reversed the effects of Cd, as reflected in plant growth, photosynthesis, elemental composition, and some biochemical parameters...
May 2016: Journal of Experimental Botany
Raymond A Jean, Matthew R DeLuzio, Alexander I Kraev, Gongyi Wang, Daniel J Boffa, Frank C Detterbeck, Zuoheng Wang, Anthony W Kim
BACKGROUND: Our goal was to develop a predictive model that identifies how preoperative risk factors and perioperative complications lead to mortality after anatomic pulmonary resections. STUDY DESIGN: This was a retrospective cohort study. The American College of Surgeons NSQIP database was examined for all patients undergoing elective lobectomies for cancer from 2005 through 2012. Fifty-eight pre- and intraoperative risk factors and 13 complications were considered for their impact on perioperative mortality within 30 days of surgery...
June 2016: Journal of the American College of Surgeons
William D Travis, Hisao Asamura, Alexander A Bankier, Mary Beth Beasley, Frank Detterbeck, Douglas B Flieder, Jin Mo Goo, Heber MacMahon, David Naidich, Andrew G Nicholson, Charles A Powell, Mathias Prokop, Ramón Rami-Porta, Valerie Rusch, Paul van Schil, Yasushi Yatabe
This article proposes codes for the primary tumor categories of adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) and a uniform way to measure tumor size in part-solid tumors for the eighth edition of the tumor, node, and metastasis classification of lung cancer. In 2011, new entities of AIS, MIA, and lepidic predominant adenocarcinoma were defined, and they were later incorporated into the 2015 World Health Organization classification of lung cancer. To fit these entities into the T component of the staging system, the Tis category is proposed for AIS, with Tis (AIS) specified if it is to be distinguished from squamous cell carcinoma in situ (SCIS), which is to be designated Tis (SCIS)...
August 2016: Journal of Thoracic Oncology
Brian N Arnold, Daniel C Thomas, Joshua E Rosen, Michelle C Salazar, Justin D Blasberg, Daniel J Boffa, Frank C Detterbeck, Anthony W Kim
INTRODUCTION: Young patients with lung cancer represent a distinct subset of patients with this disease. The National Cancer Data Base includes patients of all ages and contains detailed staging, treatment, and survival information. The objective of this study was to examine treatment patterns and outcomes in young patients with non-small cell lung cancer (NSCLC). METHODS: The National Cancer Data Base was queried for NSCLC cases from 2003 to 2009. Younger patients were defined as those aged 20 to 46 years...
July 2016: Journal of Thoracic Oncology
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