keyword
https://read.qxmd.com/read/38508515/the-iaslc-lung-cancer-staging-project-recommendation-to-introduce-spread-through-air-spaces-stas-as-a-histologic-descriptor-in-the-9-th-edition-of-the-tnm-classification-of-lung-cancer-analysis-of-4-061-pathologic-stage-i-non-small-cell-lung-carcinomas
#1
JOURNAL ARTICLE
William D Travis, Megan Eisele, Katherine K Nishimura, Rania Aly, Pietro Bertoglio, Teh-Ying Chou, Frank C Detterbeck, Jessica Donnington, Wentao Fang, Philippe Joubert, Kemp Kernstine, Young Tae Kim, Yolande Lievens, Hui Liu, Gustavo Lyons, Mari Mino-Kenudson, Andrew G Nicholson, Mauro Papotti, Ramon Rami-Porta, Valerie Rusch, Shuji Sakai, Paula Ugalde, Paul Van Schil, Jeff Yang, Vanessa J Cilento, Masaya Yotsukura, Hisao Asamura
Spread through air spaces (STAS) consists of lung cancer tumor cells that are identified beyond the edge of the main tumor in the surrounding alveolar parenchyma. It has been reported by meta-analyses to be an independent prognostic factor in the major histologic types of lung cancer, but its role in lung cancer staging is not established. To assess the clinical importance of STAS in lung cancer staging, we evaluated 4061 surgically resected pathologic Stage I R0 nonsmall cell carcinomas (NSCLC) collected from around the world in the IASLC database...
March 18, 2024: Journal of Thoracic Oncology
https://read.qxmd.com/read/38447919/the-iaslc-lung-cancer-staging-project-proposals-for-revision-of-the-tnm-stage-groups-in-the-forthcoming-ninth-edition-of-the-tnm-classification-for-lung-cancer
#2
JOURNAL ARTICLE
Ramón Rami-Porta, Katherine K Nishimura, Dorothy J Giroux, Frank Detterbeck, Giuseppe Cardillo, John G Edwards, Kwun M Fong, Meredith Giuliani, James Huang, Kemp H Kernstine, Edith M Marom, Andrew G Nicholson, Paul E Van Schil, William D Travis, Ming S Tsao, Shun-Ichi Watanabe, Valerie W Rusch, Hisao Asamura
INTRODUCTION: The tumor, node and metastasis (TNM) classification of lung cancer is periodically revised. The International Association for the Study of Lung Cancer collected and analyzed a new database to inform the forthcoming 9th edition of the TNM classification. The results are herewith presented. METHODS: After exclusions, 76,518 patients from a total of 124,581 registered patients, were available for analyses: 58,193 with clinical stage, 39,192 with pathologic stage, and 62,611 with best stage non-small cell lung cancers...
March 4, 2024: Journal of Thoracic Oncology
https://read.qxmd.com/read/38320664/the-iaslc-lung-cancer-staging-project-proposals-for-the-revision-of-the-m-descriptors-in-the-forthcoming-9th-edition-of-the-tnm-classification-of-lung-cancer
#3
JOURNAL ARTICLE
Kwun M Fong, Adam Rosenthal, Dorothy J Giroux, Katherine K Nishimura, Jeremy Erasmus, Yolande Lievens, Mirella Marino, Edith M Marom, Paul Martin Putora, Navneet Singh, Francisco Suárez, Ramon Rami-Porta, Frank Detterbeck, Wilfried Ee Eberhardt, Hisao Asamura
INTRODUCTION: This study analyzed all metastatic categories of the current tumor, node, and metastasis (TNM) classification of non-small cell lung cancer to propose modifications of the M component in the next edition (9th ) of the classification. METHODS: A database of 124,581 patients diagnosed between 2011 and 2019 was established; of these, 14,937 with NSCLC in stage IVA-IVB were available for this analysis. Overall survival was calculated using the Kaplan-Meier method, and prognosis assessed using multivariable-adjusted Cox proportional hazards regression...
February 4, 2024: Journal of Thoracic Oncology
https://read.qxmd.com/read/38310034/so-now-we-know-reflections-on-the-extent-of-resection-for-stage-i-lung-cancer
#4
JOURNAL ARTICLE
Frank Detterbeck, Sora Ely, Brooks Udelsman, Justin Blasberg, Daniel Boffa, Andrew Dhanasopon, Vincnet Mase, Gavitt Woodard
Lobectomy has been the standard treatment for stage I lung cancer in healthy patients, largely based on a randomized trial published in 1995. Nevertheless, research has continued regarding the role of sublobar resection. Three additional randomized trials addressing resection extent in healthy patients have recently been published. These 4 trials involve differences in design, eligibility, interventions, and intraoperative processes. Patients were ineligible if intraoperative assessment demonstrated stage > IA or inadequate resection margins...
December 28, 2023: Clinical Lung Cancer
https://read.qxmd.com/read/38306885/international-reproducibility-study-of-thymic-epithelial-tumors-staging-pt-stage-is-an-issue-proposals-for-improvement-a-rythmic-itmig-study
#5
JOURNAL ARTICLE
Thierry J Molina, Anja C Roden, Malgorzata Szolkowska, Shigeki Shimizu, Andre L Moreira, Lara Chalabreysse, Benjamin Besse, Vincent de Montpréville, Edith M Marom, Frank Detterbeck, Nicolas Girard, Andrew G Nicholson, Alexander Marx
INTRODUCTION: Pathologists are staging thymic epithelial tumors (TET) according to the 8th UICC/AJCC TNM system. Within the French RYTHMIC network, dedicated to TET, agreement on pathologic tumor stage (pT) among the pathology panelists was difficult. The aim of our study was to determine the interobserver reproducibility of pT at an international level, to explore the source of discrepancies and potential interventions to address these. METHODS: An international panel of pathologists was recruited through the International Thymic Malignancy Interest Group (ITMIG)...
January 24, 2024: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/38074773/brief-report-increasing-prevalence-of-ground-glass-nodules-and-semisolid-lung-lesions-on-outpatient-chest-computed-tomography-scans
#6
JOURNAL ARTICLE
Gavitt A Woodard, Brooks V Udelsman, Samantha R Prince, Justin D Blasberg, Andrew P Dhanasopon, Christopher P Gange, Leah Traube, Vincent J Mase, Daniel J Boffa, Frank C Detterbeck, Anna S Bader
INTRODUCTION: The increased use of cross-sectional imaging frequently identifies a growing number of lung nodules that require follow-up imaging studies and physician consultations. We report here the frequency of finding a ground-glass nodule (GGN) or semisolid lung lesion (SSL) in the past decade within a large academic health system. METHODS: A radiology system database review was performed on all outpatient adult chest computed tomography (CT) scans between 2013 and 2022...
December 2023: JTO clinical and research reports
https://read.qxmd.com/read/38070600/the-international-association-for-the-study-of-lung-cancer-lung-cancer-staging-project-proposals-for-the-revisions-of-the-t-descriptors-in-the-forthcoming-ninth-edition-of-the-tnm-classification-for-lung-cancer
#7
JOURNAL ARTICLE
Paul E Van Schil, Hisao Asamura, Katherine K Nishimura, Ramon Rami-Porta, Young Tae Kim, Pietro Bertoglio, Ayten K Cangir, Jessica Donington, Wentao Fang, Dorothy J Giroux, Yolande Lievens, Hui Liu, Gustavo Lyons, Shuji Sakai, William D Travis, Paula Ugalde, Chi-Fu Jeffrey Yang, Masaya Yotsukura, Frank Detterbeck
INTRODUCTION: An international database was created by the International Association for the Study of Lung Cancer to inform on the ninth edition of the TNM classification of lung cancer. The present analyses concern its T component. METHODS: Data on 124,581 patients diagnosed with lung cancer from January 1, 2011 to December 31, 2019 were submitted to the International Association for the Study of Lung Cancer database. Of these, 33,982 met the inclusion criteria for the clinical T analysis, and 30,715 met the inclusion criteria for the pathologic postsurgical analysis...
December 7, 2023: Journal of Thoracic Oncology
https://read.qxmd.com/read/38070599/postoperative-radiation-therapy-for-thymic-carcinoma-an-analysis-of-the-international-thymic-malignancy-interest-group-european-society-of-thoracic-surgeons-database
#8
JOURNAL ARTICLE
Andreas Rimner, Usman Ahmad, Stephanie M Lobaugh, Zhigang Zhang, Annemarie F Shepherd, James Huang, Alberto Antonicelli, Nicolas Girard, Bernhard Moser, Pierluigi Filosso, Marco Lucchi, Edith M Marom, Anja Roden, Frank Detterbeck, Enrico Ruffini, Charles B Simone
INTRODUCTION: R0 resection and radiation therapy have been associated with improved overall survival (OS) in patients with thymic carcinoma (TC). Here, we analyzed which subgroups of patients derive the greatest benefit from postoperative radiation therapy (PORT). METHODS: Clinical, pathologic, treatment, and survival information of 462 patients with TC from the International Thymic Malignancy Interest Group/European Society of Thoracic Surgeons database were analyzed...
December 8, 2023: Journal of Thoracic Oncology
https://read.qxmd.com/read/37866624/the-international-association-for-the-study-of-lung-cancer-staging-project-for-lung-cancer-proposals-for-the-revision-of-the-n-descriptors-in-the-forthcoming-ninth-edition-of-the-tnm-classification-for-lung-cancer
#9
JOURNAL ARTICLE
James Huang, Raymond U Osarogiagbon, Dorothy J Giroux, Katherine K Nishimura, Andrea Bille, Giuseppe Cardillo, Frank Detterbeck, Kemp Kernstine, Hong Kwan Kim, Yolande Lievens, Eric Lim, Edith Marom, Helmut Prosch, Paul Martin Putora, Ramon Rami-Porta, David Rice, Gaetano Rocco, Valerie W Rusch, Isabelle Opitz, Francisco Suarez Vasquez, Paul Van Schil, Chi-Fu Jeffrey Yang, Hisao Asamura
INTRODUCTION: The accurate assessment of nodal (N) status is crucial to the management and prognostication of nonmetastatic NSCLC. We sought to determine whether the current N descriptors should be maintained or revised for the upcoming ninth edition of the international TNM lung cancer staging system. METHODS: Data were assembled by the International Association for the Study of Lung Cancer on patients with NSCLC, detailing both clinical and pathologic N status, with information about anatomical location and individual station-level identification...
October 20, 2023: Journal of Thoracic Oncology
https://read.qxmd.com/read/37832536/impact-of-the-covid-19-pandemic-on-lung-cancer-screening-processes-in-a-northeast-tertiary-health-care-network
#10
JOURNAL ARTICLE
Brooks V Udelsman, Frank Detterbeck, Lynn Tanoue, Vincent Mase, Daniel Boffa, Justin Blasberg, Andrew Dhanasopon, Sora Ely, Louis J Mazzarelli, Anna Bader, Gavitt Woodard
The coronavirus disease 2019 (COVID-19) pandemic disrupted health care systems, including implementation of lung cancer screening programs. The impact and recovery from this disruption on screening processes is not well appreciated. Herein, the radiology database of a Northeast tertiary health care network was reviewed before and during the pandemic (2013-2022). In the 3 months before the pandemic, an average of 77.3 lung cancer screening with computed tomography scans (LCS-CT) were performed per month. The average dropped to 23...
October 12, 2023: Journal of Computer Assisted Tomography
https://read.qxmd.com/read/37774950/the-iaslc-thymic-epithelial-tumors-staging-project-proposals-for-the-n-and-the-m-components-for-the-forthcoming-9th-edition-of-the-tnm-classification-of-malignant-tumors
#11
JOURNAL ARTICLE
Wentao Fang, Nicolas Girard, Vanessa Cilento, Emily Goren, Daniel Dibaba, Enrico Ruffini, Usman Ahmad, Sarit Appel, Andrea Bille, Souheil Boubia, Cecilia Brambilla, Ayten Kayi Cangir, Frank Detterbeck, Conrad Falkson, Pier Luigi Filosso, Giuseppe Giaccone, Francesco Guerrera, James Huang, Maurizio Infante, Dong Kwan Kim, Marco Lucchi, Mirella Marino, Edith M Marom, Andrew G Nicholson, Meinoshin Okumura, Ramon Rami-Porta, Andreas Rimner, Charles B Simone, Hisao Asamura
INTRODUCTION: Stage classification is an important underpinning of management in patients with cancer, and rests on a combination of three components: T for tumor extent, N for nodal involvement, and M for distant metastases. This article details the revision of the N and the M components of thymic epithelial tumors for the 9th edition of the TNM classification of malignant tumors proposed by the Thymic Domain of the International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee...
September 27, 2023: Journal of Thoracic Oncology
https://read.qxmd.com/read/37758342/the-only-constant-is-change-introducing-the-international-association-for-the-study-of-lung-cancer-proposals-for-the-ninth-edition-of-tnm-stage-classification-of-thoracic-tumors
#12
EDITORIAL
Frank C Detterbeck, Hisao Asamura, Ramón Rami-Porta, Valerie W Rusch
No abstract text is available yet for this article.
October 2023: Journal of Thoracic Oncology
https://read.qxmd.com/read/37717854/completeness-of-resection-and-long-term-survival-of-patients-undergoing-resection-for-pathological-t3-non-small-cell-lung-cancer-an-international-association-for-the-study-of-lung-cancer-analysis
#13
JOURNAL ARTICLE
Paula Ugalde Figueroa, Edouard Marques, Vanessa J Cilento, Dorothy J Giroux, Katherine K Nishimura, Frank C Detterbeck, Paul Van Schil, Pietro Bertoglio, Chi-Fu Jeffrey Yang, Wentao Fang
INTRODUCTION: Currently, tumors with different histopathological characteristics and oncologic outcomes comprise the T3 category of the 8th edition tumor, node, and metastasis (TNM) classification for lung cancers. To better understand the T3 category, we evaluated completeness of resection and long-term survival in patients undergoing resection for T3 non-small-cell lung cancer (NSCLC). METHODS: The International Association for the Study of Lung Cancer 1999-2010 database was queried for patients with pathological T3N0M0 NSCLC who underwent lobectomy or pneumonectomy...
September 15, 2023: Journal of Thoracic Oncology
https://read.qxmd.com/read/37702630/the-international-association-for-the-study-of-lung-cancer-thymic-epithelial-tumors-staging-project-an-overview-of-the-central-database-informing-revision-of-the-forthcoming-ninth-edition-of-the-tnm-classification-of-malignant-tumors
#14
REVIEW
Andreas Rimner, Enrico Ruffini, Vanessa Cilento, Emily Goren, Usman Ahmad, Sarit Appel, Andrea Bille, Souheil Boubia, Cecilia Brambilla, Ayten Kayi Cangir, Frank Detterbeck, Conrad Falkson, Wentao Fang, Pier Luigi Filosso, Giuseppe Giaccone, Nicolas Girard, Francesco Guerrera, James Huang, Maurizio Infante, Dong Kwan Kim, Marco Lucchi, Mirella Marino, Edith M Marom, Andrew G Nicholson, Meinoshin Okumura, Ramon Rami-Porta, Charles B Simone, Hisao Asamura
INTRODUCTION: In 2014, a TNM-based system for thymic epithelial tumors was proposed. The TNM stage classification system was published as a result of a joint project from the International Association for the Study of Lung Cancer and the International Thymic Malignancy Interest Group for the eighth edition of the American Joint Commission on Cancer and the Union for International Cancer Control stage classification system. The Thymic Domain of the Staging and Prognostic Factors Committee of the International Association for the Study of Lung Cancer received the mandate to make proposals for the ninth edition of the TNM stage classification...
October 2023: Journal of Thoracic Oncology
https://read.qxmd.com/read/37689391/the-iaslc-thymic-epithelial-tumors-staging-project-proposal-for-a-stage-classification-for-the-forthcoming-9-th-edition-of-the-tnm-classification-of-malignant-tumors
#15
JOURNAL ARTICLE
Enrico Ruffini, James Huang, Vanessa Cilento, Emily Goren, Frank Detterbeck, Usman Ahmad, Sarit Appel, Andrea Bille, Souheil Boubia, Cecilia Brambilla, Ayten Kayi Cangir, Conrad Falkson, Wentao Fang, Pier Luigi Filosso, Giuseppe Giaccone, Nicolas Girard, Francesco Guerrera, Maurizio Infante, Dong Kwan Kim, Marco Lucchi, Mirella Marino, Edith M Marom, Andrew G Nicholson, Meinoshin Okumura, Ramon Rami-Porta, Andreas Rimner, Charles B Simone, Hisao Asamura
INTRODUCTION: A tumor, node, metastasis (TNM)-based system for all types of thymic epithelial tumors (TET) was introduced in the 8th edition of the TNM classification of thoracic malignancies. The Thymic Domain of the Staging and Prognostic Factors Committee of the International Association for the Study of Lung Cancer, composed of multispecialty international experts, was charged to develop proposals for the 9th edition. This article outlines the proposed definitions for the T, the N and the M components, and their combination into stage groups...
September 7, 2023: Journal of Thoracic Oncology
https://read.qxmd.com/read/37689390/the-international-association-for-the-study-of-lung-cancer-thymic-epithelial-tumor-staging-project-a-re-assessment-of-the-international-thymic-malignancy-interest-group-international-association-for-the-study-of-lung-cancer-lymph-node-map-for-thymic-epithelial
#16
JOURNAL ARTICLE
Edith M Marom, Wentao Fang, Enrico Ruffini, Frank Detterbeck, Usman Ahmad, Sarit Appel, Andrea Bille, Souheil Boubia, Cecilia Brambilla, Vanessa Cilento, Ayten Kayi Cangir, Conrad Falkson, Pier Luigi Filosso, Giuseppe Giaccone, Nicolas Girard, Emily Goren, Francesco Guerrera, James Huang, Maurizio Infante, Dong-Kwan Kim, Marco Lucchi, Mirella Marino, Andrew G Nicholson, Meinoshin Okumura, Ramon Rami-Porta, Andreas Rimner, Charles B Simone, Hisao Asamura
INTRODUCTION: A lymph node map is the pillar on which accurate assignment and documentation of nodal classification stands. The International Thymic Malignancy Interest Group created the first map for thymic epithelial malignancies in conjunction with the eighth edition of the TNM classification, representing the first official TNM classification of thymic epithelial malignancies. The map was based on clinical experience and published studies, but it was largely empirical because of limited available data...
September 9, 2023: Journal of Thoracic Oncology
https://read.qxmd.com/read/37634808/the-international-association-for-the-study-of-lung-cancer-thymic-epithelial-tumor-staging-project-proposal-for-the-t-component-for-the-forthcoming-ninth-edition-of-the-tnm-classification-of-malignant-tumors
#17
JOURNAL ARTICLE
Meinoshin Okumura, Mirella Marino, Vanessa Cilento, Emily Goren, Enrico Ruffini, Daniel Dibaba, Usman Ahmad, Sarit Appel, Andrea Bille, Souheil Boubia, Cecilia Brambilla, Ayten Kayi Cangir, Frank Detterbeck, Conrad Falkson, Wentao Fang, Pier Luigi Filosso, Giuseppe Giaccone, Nicolas Girard, Francesco Guerrera, James Huang, Maurizio Infante, Dong Kwan Kim, Marco Lucchi, Edith M Marom, Andrew G Nicholson, Ramon Rami-Porta, Andreas Rimner, Charles B Simone, Hisao Asamura
INTRODUCTION: A TNM-based stage classification system of thymic epithelial tumors was adopted for the eighth edition of the stage classification of malignant tumors. The Thymic Domain of the Staging and Prognostics Factor Committee of the International Association for the Study of Lung Cancer developed a new database with the purpose to make proposals for the ninth edition stage classification system. This article outlines the proposed definitions for the T categories for the ninth edition TNM stage classification of thymic malignancies...
August 25, 2023: Journal of Thoracic Oncology
https://read.qxmd.com/read/37487666/autologous-humanized-pdx-modeling-for-immuno-oncology-recapitulates-features-of-the-human-tumor-microenvironment
#18
JOURNAL ARTICLE
Michael Chiorazzi, Jan Martinek, Bradley Krasnick, Yunjiang Zheng, Keenan J Robbins, Rihao Qu, Gabriel Kaufmann, Zachary Skidmore, Melani Juric, Laura A Henze, Frederic Brösecke, Adam Adonyi, Jun Zhao, Liang Shan, Esen Sefik, Jacqueline Mudd, Ye Bi, S Peter Goedegebuure, Malachi Griffith, Obi Griffith, Abimbola Oyedeji, Sofia Fertuzinhos, Rolando Garcia-Milian, Daniel Boffa, Frank Detterbeck, Andrew Dhanasopon, Justin Blasberg, Benjamin Judson, Scott Gettinger, Katerina Politi, Yuval Kluger, Karolina Palucka, Ryan C Fields, Richard A Flavell
BACKGROUND: Interactions between immune and tumor cells are critical to determining cancer progression and response. In addition, preclinical prediction of immune-related drug efficacy is limited by interspecies differences between human and mouse, as well as inter-person germline and somatic variation. To address these gaps, we developed an autologous system that models the tumor microenvironment (TME) from individual patients with solid tumors. METHOD: With patient-derived bone marrow hematopoietic stem and progenitor cells (HSPCs), we engrafted a patient's hematopoietic system in MISTRG6 mice, followed by transfer of patient-derived xenograft (PDX) tissue, providing a fully genetically matched model to recapitulate the individual's TME...
July 2023: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/37164573/cancer-directed-surgery-for-mesothelioma-a-team-sport
#19
EDITORIAL
Barry C Gibney, Frank C Detterbeck
No abstract text is available yet for this article.
May 2023: Chest
https://read.qxmd.com/read/36910113/lung-cancer-with-air-lucency-a-systematic-review-and-clinical-management-guide
#20
REVIEW
Frank C Detterbeck, Ulas Kumbasar, Andrew X Li, Ami N Rubinowitz, Leah Traube, Babina Gosangi, Brooks V Udelsman, Brett C Bade, Sora Ely, Gaspar Barreto, Lynn T Tanoue, Edith M Marom, M Patricia Rivera
BACKGROUND: Lung cancers with air lucency are poorly understood, often recognized only after substantial progression. METHODS: From a systematic review (PubMed and EMBASE, 2000-2022, terms related to cystic, cavitary, bulla, pseudocavitary, bubble-like, date 10-30-2022) 49 studies were selected using broad inclusion criteria (case series of ≥10 cases up to trials and reviews). There was no source of funding. Primary evidence relevant to clinical management issues was assembled...
February 28, 2023: Journal of Thoracic Disease
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