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https://www.readbyqxmd.com/read/29236339/physical-activity-level-among-children-recovering-from-severe-acute-malnutrition
#1
Esther Babirekere-Iriso, Maren Johanne Heilskov Rytter, Hanifa Namusoke, Ezekiel Mupere, Kim F Michaelsen, Søren Brage, Ken D Stark, Lotte Lauritzen, André Briend, Henrik Friis, Daniel Faurholt-Jepsen
OBJECTIVE: To assess the level and predictors of physical activity at discharge among children recovering from severe acute malnutrition (SAM). METHODS: We conducted a prospective study among 69 children 6 - 59 months of age admitted with SAM for nutritional rehabilitation at Mulago National Referral Hospital, Uganda. Using hip-mounted tri-axial accelerometers, we measured physical activity expressed as counts per minute (cpm) during the last three days of hospital treatment...
December 13, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29236110/simultaneous-monitoring-of-different-vitrification-solution-components-permeating-into-tissues
#2
Andrés Vásquez-Rivera, Kim K Sommer, Harriëtte Oldenhof, Adam Z Higgins, Kelvin G M Brockbank, Andres Hilfiker, Willem F Wolkers
Cryopreservation can be used for long-term preservation of tissues and organs. It relies on using complex mixtures of cryoprotective agents (CPAs) to reduce the damaging effects of freezing, but care should be taken to avoid toxic effects of CPAs themselves. In order to rationally design cryopreservation strategies for tissues, it is important to precisely determine permeation kinetics of the protectants that are used to ensure maximum permeation, while minimizing the exposure time and toxicity effects. This is particularly challenging with protectant solutions consisting of multiple components each with different physical properties and diffusing at a different rate...
December 13, 2017: Analyst
https://www.readbyqxmd.com/read/29236081/pharmacogenomics-guided-personalization-of-warfarin-and-tamoxifen
#3
REVIEW
Theodore J Wigle, Laura E Jansen, Wendy A Teft, Richard B Kim
The use of pharmacogenomics to personalize drug therapy has been a long-sought goal for warfarin and tamoxifen. However, conflicting evidence has created reason for hesitation in recommending pharmacogenomics-guided care for both drugs. This review will provide a summary of the evidence to date on the association between cytochrome P450 enzymes and the clinical end points of warfarin and tamoxifen therapy. Further, highlighting the clinical experiences that we have gained over the past ten years of running a personalized medicine program, we will offer our perspectives on the utility and the limitations of pharmacogenomics-guided care for warfarin and tamoxifen therapy...
December 13, 2017: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29236057/development-of-houttuynia-cordata-extract-loaded-solid-lipid-nanoparticles-for-oral-delivery-high-drug-loading-efficiency-and-controlled-release
#4
Ju-Heon Kim, Jong-Suep Baek, Jin-Kyu Park, Bong-Joo Lee, Min-Soo Kim, Sung-Joo Hwang, Jae-Young Lee, Cheong-Weon Cho
Houttuynia cordata (H. cordata) has been used for diuresis and detoxification in folk medicine as well as a herbal medicine with antiviral and antibacterial activities. H. cordata extract-loaded solid lipid nanoparticles (H-SLNs) were prepared with various concentration of poloxamer 188 or poloxamer 407 by a hot homogenization and ultrasonication method. H-SLNs dispersion was freeze-dried with or without trehalose as a cryoprotectant. The physicochemical characteristics of H-SLNs were evaluated by dynamic laser scattering (DLS), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM)...
December 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29235956/the-experience-of-korean-nurses-during-the-middle-east-respiratory-syndrome-outbreak
#5
Sook-Bin Im, Steven L Baumann, Mina Ahn, Hyunok Kim, Bock-Hui Youn, MinKyoung Park, Ok-Ja Lee
The authors in this article explore the experiences of eight South Korean nurses during an outbreak of the Middle East Respiratory Syndrome (MERS), which took place in the fall of 2015. These nurses were mandated to remain in isolation in an intensive care unit (ICU) dedicated to the treatment of the patients with the MERS virus for 7 days. Parse's humanbecoming theory was used to frame the discussion. Three themes found in the nurse's stories are discussed: feeling hopeless and cut off, feeling shame and overworked, and feeling pride in fulfilling a duty...
January 2018: Nursing Science Quarterly
https://www.readbyqxmd.com/read/29235879/experimental-studies-on-artifacts-and-tumor-enhancement-on-gadoxetic-acid-enhanced-arterial-phase-liver-mri-in-a-rabbit-vx2-tumor-model
#6
Takahiro Tsuboyama, Gregor Jost, Tonsok Kim, Masatoshi Hori, Hiromitsu Onishi, Hubertus Pietsch, Noriyuki Tomiyama
Background Rapid injection of gadoxetic acid is reported to produce more frequent artifacts and lower vascular enhancement on arterial phase liver magnetic resonance imaging (MRI). However, its effect on tumor enhancement and the mechanism of the artifacts remain unclear. Purpose To evaluate the effect of rapid injection of gadoxetic acid on artifacts and tumor enhancement during arterial phase liver MRI, and on arterial blood gases (ABGs) which may explain the cause of the artifacts. Material and Methods ABG analysis was performed in 13 free-breathing rabbits after rapid injection (1 mL/s; injection time = 0...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29235876/suppressing-polysulfide-dissolution-via-cohesive-forces-by-interwoven-carbon-nanofibers-for-high-areal-capacity-lithium-sulfur-batteries
#7
Jong Hyuk Yun, Joo-Hyung Kim, Do Kyung Kim, Hyun-Wook Lee
Nanostructural design renders several breakthroughs for the construction of high-performance materials and devices, including energy-storage systems. Although attempts made toward electrode engineering have improved the existing drawbacks, nanoengineering is still hindered by some issues. To achieve practical applications of lithium-sulfur (Li-S) batteries, it is difficult to attain a high areal capacity with stable cycling. Physical encapsulation via nanostructural design not only can resolve the issue of lithium polysulfide dissolution during the electrochemical cycling but also can offer significant contact resistance, which in turn can decrease the kinetics, particularly at a high sulfur loading...
December 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/29235865/synergetic-catalysis-of-copper-and-iron-in-oxidation-of-reduced-keggin-heteropolytungstates-by-dioxygen
#8
Mooeung Kim, Masoumeh Chamack, Yurii V Geletii, Craig L Hill
Polyoxometalates (POMs) and in particularly Keggin heteropolytungstates are much studied and commercially important catalysts for dioxygen-based oxidation processes. The rate-limiting step in many POM-catalyzed O2-based oxidations is reoxidation of the reduced POM by O2. We report here that this reoxidation process, as represented by the one-electron-reduced Keggin complexes POMred (α-PW12O404- and α-SiVW11O406-) reacting with O2, is efficiently catalyzed by a combination of copper and iron complexes. The reaction kinetics and mechanism have been comprehensively studied in sulfate and phosphate buffer at pH 1...
December 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29235851/semi-interpenetrating-polymer-network-composite-gel-electrolytes-employing-vinyl-functionalized-silica-for-lithium-oxygen-batteries-with-enhanced-cycling-stability
#9
Hyun-Sik Woo, Yong-Bok Moon, Samuel Seo, Ho-Taek Lee, Dong-Won Kim
A major challenge of lithium-oxygen batteries is to develop a stable electrolyte not only to suppress solvent evaporation and lithium dendrite growth, but also to resist against the attack by superoxide anion radical formed at the positive electrode. The present study demonstrates the enhancement of cycling stability by addressing the above challenges through the use of three-dimensional semi-interpenetrating polymer network (semi-IPN) composite gel polymer electrolyte when fabricating the lithium-oxygen cell...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29235849/all-small-molecule-solar-cells-incorporating-ndi-based-acceptors-synthesis-and-full-characterization
#10
Jisu Hong, Yeon Hee Ha, Hyojung Cha, Ran Kim, Yu Jin Kim, Chan Eon Park, James R Durrant, Soon-Ki Kwon, Tae Kyu An, Yun-Hi Kim
A series of naphthalene diimide (NDI)-based small molecules were synthesized as nonfullerene acceptors and incorporated in all-small-molecule solar cells. Three NDI-based small molecules, NDICN-T, NDICN-BT, and NDICN-TVT, were designed with different linkers between two NDI units to induce the different conjugation length and modulate the geometric structures of the NDI dimers. The small NDI-based dimer electron acceptors with slip-stacked structures that facilitate π-π stacking interactions and/or hinder excessive aggregation exhibited different morphological behaviors, such as miscibility or crystallinity in bulk heterojunction blends with 7,7'-(4,4-bis(2-ethylhexyl)-4H-silolo[3,2-b:4,5-b']dithiophene-2,6-diyl)bis(6-fluoro-4-(5'-hexyl-[2,2'-bithiophen]-5-yl)benzo[c][1,2,5]thiadiazole) (DTS-F) electron donors...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29235841/pp-heterojunction-of-nickel-oxide-decorated-cobalt-oxide-nanorods-for-enhanced-sensitivity-and-selectivity-toward-volatile-organic-compounds
#11
Jun Min Suh, Woonbae Sohn, Young-Seok Shim, Jang-Sik Choi, Young Geun Song, Taemin Ludvic Kim, Jong-Myeong Jeon, Ki Chang Kwon, Kyoung Soon Choi, Chong-Yun Kang, Hyung-Gi Byun, Ho Won Jang
The utilization of p-p isotype heterojunctions is an effective strategy to enhance the gas sensing properties of metal-oxide semiconductors, but most previous studies focused on p-n heterojunctions owing to their simple mechanism of formation of depletion layers. However, a proper choice of isotype semiconductors with appropriate energy bands can also contribute to the enhancement of the gas sensing performance. Herein, we report nickel oxide (NiO)-decorated cobalt oxide (Co3O4) nanorods (NRs) fabricated using multiple-step glancing angle deposition method...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29235603/a-graphene-mesh-as-a-hybrid-electrode-for-foldable-devices
#12
E H Cho, M J Kim, H Sohn, W H Shin, J Y Won, Y Kim, C Kwak, C S Lee, Y S Woo
A graphene mesh with arrays of micro-holes was fabricated on a polymer substrate using photolithography for use as an electrode in flexible devices. The optimal mesh structure with high optical transmittance and electrical conductivity was designed using a finite element method, in which the conductivity of the mesh was simulated as a function of structure, size, and periodicity of the hole array. The sheet resistance of the graphene mesh was lowered to that of a graphene monolayer by chemical doping and found to be 330 Ω Sq-1 at 98...
December 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/29235580/corrigendum-interleukin-7-induces-osteoclast-formation-via-stat5-independent-of-receptor-activator-of-nf-kappab-ligand
#13
Jin-Hee Kim, Ji Hyun Sim, Sunkyung Lee, Min A Seol, Sang-Kyu Ye, Hyun Mu Shin, Eun Bong Lee, Yun Jong Lee, Yun Jung Choi, Wan-Hee Yoo, Jin Hyun Kim, Wan-Uk Kim, Dong-Sup Lee, Jin-Hong Kim, Insoo Kang, Seong Wook Kang, Hang-Rae Kim
[This corrects the article on p. 1376 in vol. 8, PMID: 29104576.].
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29235540/characteristic-dysmorphic-features-in-congenital-disorders-of-glycosylation-type-iib
#14
Yoon-Myung Kim, Go Hun Seo, Euiseok Jung, Ja-Hyun Jang, Sook Za Kim, Beom Hee Lee
Over 100 types of congenital disorders of glycosylation (CDG) have been reported and the number is rapidly increasing. However, each type is very rare and is problematic to diagnose. Mannosyl-oligosaccharide glucosidase (MOGS)-CDG (CDG type IIb) is an extremely rare CDG that has only been reported in three patients from two unrelated families. Using targeted exome sequencing, we identified another patient affected by this condition. This patient had increased serum trisialotransferrin levels. Importantly, a review of the features of all four patients revealed the recognizable clinical hallmarks of MOGS-CDG...
December 13, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/29235512/a-multimodal-biomicroscopic-system-based-on-high-frequency-acoustic-radiation-force-impulse-and-multispectral-imaging-techniques-for-tumor-characterization-ex-vivo
#15
Jihun Kim, Anna Seo, Jun-Young Kim, Sung Hyouk Choi, Hyung-Jin Yoon, Eunjoo Kim, Jae Youn Hwang
We report a multimodal biomicroscopic system which offers high-frequency ultrasound B-mode, acoustic radiation force impulse (ARFI), and multispectral imaging for qualitative tumor characterization ex vivo. Examinations of resected tissues from diseased regions such as tumors are crucial procedures during surgical operations to treat cancer. Particularly, if tiny tumors remain at surgical sites after tumor resection, such tumors can result in unwanted outcomes, such as cancer recurrence or metastasis to other organs...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235507/blood-brain-glucose-transfer-in-alzheimer-s-disease-effect-of-glp-1-analog-treatment
#16
Michael Gejl, Birgitte Brock, Lærke Egefjord, Kim Vang, Jørgen Rungby, Albert Gjedde
There are fewer than normal glucose transporters at the blood-brain barrier (BBB) in Alzheimer's disease (AD). When reduced expression of transporters aggravates the symptoms of AD, the transporters become a potential target of therapy. The incretin hormone GLP-1 prevents the decline of cerebral metabolic rate for glucose (CMRglc) in AD, and GLP-1 may serve to raise transporter numbers. We hypothesized that the GLP-1 analog liraglutide would prevent the decline of CMRglc in AD by raising blood-brain glucose transfer, depending on the duration of disease...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235501/room-temperature-performance-of-poly-ethylene-ether-carbonate-based-solid-polymer-electrolytes-for-all-solid-state-lithium-batteries
#17
Yun-Chae Jung, Myung-Soo Park, Duck-Hyun Kim, Makoto Ue, Ali Eftekhari, Dong-Won Kim
Amorphous poly(ethylene ether carbonate) (PEEC), which is a copolymer of ethylene oxide and ethylene carbonate, was synthesized by ring-opening polymerization of ethylene carbonate. This route overcame the common issue of low conductivity of poly(ethylene oxide)(PEO)-based solid polymer electrolytes at low temperatures, and thus the solid polymer electrolyte could be successfully employed at the room temperature. Introducing the ethylene carbonate units into PEEC improved the ionic conductivity, electrochemical stability and lithium transference number compared with PEO...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235473/metasurface-assisted-phase-matching-free-second-harmonic-generation-in-lithium-niobate-waveguides
#18
Cheng Wang, Zhaoyi Li, Myoung-Hwan Kim, Xiao Xiong, Xi-Feng Ren, Guang-Can Guo, Nanfang Yu, Marko Lončar
The phase-matching condition is a key aspect in nonlinear wavelength conversion processes, which requires the momenta of the photons involved in the processes to be conserved. Conventionally, nonlinear phase matching is achieved using either birefringent or periodically poled nonlinear crystals, which requires careful dispersion engineering and is usually narrowband. In recent years, metasurfaces consisting of densely packed arrays of optical antennas have been demonstrated to provide an effective optical momentum to bend light in arbitrary ways...
December 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29235467/in-situ-functional-dissection-of-rna-cis-regulatory-elements-by-multiplex-crispr-cas9-genome-engineering
#19
Qianxin Wu, Quentin R V Ferry, Toni A Baeumler, Yale S Michaels, Dimitrios M Vitsios, Omer Habib, Roland Arnold, Xiaowei Jiang, Stefano Maio, Bruno R Steinkraus, Marta Tapia, Paolo Piazza, Ni Xu, Georg A Holländer, Thomas A Milne, Jin-Soo Kim, Anton J Enright, Andrew R Bassett, Tudor A Fulga
RNA regulatory elements (RREs) are an important yet relatively under-explored facet of gene regulation. Deciphering the prevalence and functional impact of this post-transcriptional control layer requires technologies for disrupting RREs without perturbing cellular homeostasis. Here we describe genome-engineering based evaluation of RNA regulatory element activity (GenERA), a clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 platform for in situ high-content functional analysis of RREs...
December 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29235455/atmospheric-pressure-mass-spectrometric-imaging-of-live-hippocampal-tissue-slices-with-subcellular-spatial-resolution
#20
Jae Young Kim, Eun Seok Seo, Hyunmin Kim, Ji-Won Park, Dong-Kwon Lim, Dae Won Moon
We report a high spatial resolution mass spectrometry (MS) system that allows us to image live hippocampal tissue slices under open-air atmospheric pressure (AP) and ambient temperature conditions at the subcellular level. The method is based on an efficient desorption process by femtosecond (fs) laser assisted with nanoparticles and a subsequent ionization step by applying nonthermal plasma, termed AP nanoparticle and plasma assisted laser desorption ionization (AP-nanoPALDI) MS method. Combining the AP-nanoPALDI with microscopic sample scanning, MS imaging with spatial resolution of 2...
December 13, 2017: Nature Communications
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