Hao Li, Praneeth Namburi, Jacob M Olson, Matilde Borio, Mackenzie E Lemieux, Anna Beyeler, Gwendolyn G Calhoon, Natsuko Hitora-Imamura, Austin A Coley, Avraham Libster, Aneesh Bal, Xin Jin, Huan Wang, Caroline Jia, Sourav R Choudhury, Xi Shi, Ada C Felix-Ortiz, Verónica de la Fuente, Vanessa P Barth, Hunter O King, Ehsan M Izadmehr, Jasmin S Revanna, Kanha Batra, Kyle B Fischer, Laurel R Keyes, Nancy Padilla-Coreano, Cody A Siciliano, Kenneth M McCullough, Romy Wichmann, Kerry J Ressler, Ila R Fiete, Feng Zhang, Yulong Li, Kay M Tye
The ability to associate temporally segregated information and assign positive or negative valence to environmental cues is paramount for survival. Studies have shown that different projections from the basolateral amygdala (BLA) are potentiated following reward or punishment learning1-7 . However, we do not yet understand how valence-specific information is routed to the BLA neurons with the appropriate downstream projections, nor do we understand how to reconcile the sub-second timescales of synaptic plasticity8-11 with the longer timescales separating the predictive cues from their outcomes...
August 2022: Nature