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Emily Nelson, John H Calhoon
No abstract text is available yet for this article.
October 2016: Annals of Thoracic Surgery
Nels D Carroll, Kevin M Beers, Elaine M Maldonado, John H Calhoon, S Adil Husain
Reparative procedures are not always feasible in congenitally abnormal mitral valves. Mechanical prosthesis has been accepted as the choice for valve replacement in the pediatric population. This report describes a case of congenital mitral valve disease requiring mitral valve replacement. The infant's mitral valve annulus was not amenable to placement of the smallest available mechanical prosthesis. The approach used here for annular and subvalvular enlargement facilitated implantation of a larger prosthesis for congenital mitral valve replacement...
September 2016: Annals of Thoracic Surgery
Joseph A Dearani, Jeffrey P Jacobs, R Morton Bolman, JaBaris D Swain, Luca A Vricella, Samuel Weinstein, Emily A Farkas, John H Calhoon
Noncommunicable diseases account for 38 million deaths each year, and approximately 75% of these deaths occur in the developing world. The most common causes include cardiovascular diseases, cancer, respiratory diseases, and diabetes mellitus. Many adults with acquired cardiothoracic disease around the world have limited access to health care. In addition, congenital heart disease is present in approximately 1% of live births and is therefore the most common congenital abnormality. More than one million children in the world are born with congenital heart disease each year, and approximately 90% of these children receive suboptimal care or have no access to care...
September 2016: Annals of Thoracic Surgery
Anna Beyeler, Praneeth Namburi, Gordon F Glober, Clémence Simonnet, Gwendolyn G Calhoon, Garrett F Conyers, Robert Luck, Craig P Wildes, Kay M Tye
Although the basolateral amygdala (BLA) is known to play a critical role in the formation of memories of both positive and negative valence, the coding and routing of valence-related information is poorly understood. Here, we recorded BLA neurons during the retrieval of associative memories and used optogenetic-mediated phototagging to identify populations of neurons that synapse in the nucleus accumbens (NAc), the central amygdala (CeA), or ventral hippocampus (vHPC). We found that despite heterogeneous neural responses within each population, the proportions of BLA-NAc neurons excited by reward predictive cues and of BLA-CeA neurons excited by aversion predictive cues were higher than within the entire BLA...
April 20, 2016: Neuron
Mark S Allen, John H Calhoon, David Fullerton, Richard Shemin, Keith Naunheim, Edward Verrier, John Doty, Douglas J Mathisen
BACKGROUND: The Joint Council on Thoracic Surgical Education was formed in 2008 to improve cardiothoracic education. Resident learning has been a concern as reflected in declining passing rates on the American Board of Thoracic Surgery examinations. The Joint Council on Thoracic Surgical Education piloted a program to determine whether early exposure to a cardiothoracic curriculum through participation in a board review course would improve learning. The purpose of this paper is to report the results of this project...
April 2016: Annals of Thoracic Surgery
Praneeth Namburi, Ream Al-Hasani, Gwendolyn G Calhoon, Michael R Bruchas, Kay M Tye
In order to thrive, animals must be able to recognize aversive and appetitive stimuli within the environment and subsequently initiate appropriate behavioral responses. This assignment of positive or negative valence to a stimulus is a key feature of emotional processing, the neural substrates of which have been a topic of study for several decades. Until recently, the result of this work has been the identification of specific brain regions, such as the basolateral amygdala (BLA) and nucleus accumbens (NAc), as important to valence encoding...
June 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Gwendolyn G Calhoon, Kay M Tye
Although anxiety disorders represent a major societal problem demanding new therapeutic targets, these efforts have languished in the absence of a mechanistic understanding of this subjective emotional state. While it is impossible to know with certainty the subjective experience of a rodent, rodent models hold promise in dissecting well-conserved limbic circuits. The application of modern approaches in neuroscience has already begun to unmask the neural circuit intricacies underlying anxiety by allowing direct examination of hypotheses drawn from existing psychological concepts...
October 2015: Nature Neuroscience
John H Calhoon
No abstract text is available yet for this article.
November 2015: Journal of Thoracic and Cardiovascular Surgery
Elisabeth A Calhoon, Jennifer Ro, Joseph B Williams
The membrane pacemaker hypotheses of metabolism and aging are distinct, but interrelated hypotheses positing that increases in unsaturation of lipids within membranes are correlated with increasing basal metabolic rate and decreasing longevity, respectively. The two hypotheses each have evidence that either supports or contradicts them, but consensus has failed to emerge. In this review, we identify sources of weakness of previous studies supporting and contradicting these hypotheses and suggest different methods and lines of inquiry...
October 2015: Chemistry and Physics of Lipids
Bhawna Gupta, Ali Dodge-Khatami, Charles D Fraser, John H Calhoon, Makram R Ebeid, Mary B Taylor, Jorge D Salazar
BACKGROUND: Management of systemic semilunar valve disease in growing, young patients is challenging. When replacement is necessary, use of a pulmonary autograft is sometimes not possible for anatomic, pathologic, or technical reasons or due to parental or patient preference. We employed a stentless, porcine, full-root bioprosthesis in this setting and report our outcomes. METHODS: Over 9 years (2005 to 2013), 24 patients of mean age 13.1 years (range, 3 months to 20...
August 2015: Annals of Thoracic Surgery
Mariah E Dorner, Ryan D McMunn, Thomas G Bartholow, Brecken E Calhoon, Michelle R Conlon, Jessica M Dulli, Samuel C Fehling, Cody R Fisher, Shane W Hodgson, Shawn W Keenan, Alyssa N Kruger, Justin W Mabin, Daniel L Mazula, Christopher A Monte, Augustus Olthafer, Ashley E Sexton, Beatrice R Soderholm, Alexander M Strom, Sanchita Hati
Cytochrome P450 enzymes are hemeproteins that catalyze the monooxygenation of a wide-range of structurally diverse substrates of endogenous and exogenous origin. These heme monooxygenases receive electrons from NADH/NADPH via electron transfer proteins. The cytochrome P450 enzymes, which constitute a diverse superfamily of more than 8,700 proteins, share a common tertiary fold but < 25% sequence identity. Based on their electron transfer protein partner, cytochrome P450 proteins are classified into six broad classes...
September 2015: Protein Science: a Publication of the Protein Society
Kellen Calinger, Elisabeth Calhoon, Hsiao-Chi Chang, James Whitacre, John Wenzel, Liza Comita, Simon Queenborough
Anthropogenic disturbances often change ecological communities and provide opportunities for non-native species invasion. Understanding the impacts of disturbances on species invasion is therefore crucial for invasive species management. We used generalized linear mixed effects models to explore the influence of land-use history and distance to roads on the occurrence and abundance of two invasive plant species (Rosa multiflora and Berberis thunbergii) in a 900-ha deciduous forest in the eastern U.S.A., the Powdermill Nature Reserve...
2015: PloS One
Praneeth Namburi, Anna Beyeler, Suzuko Yorozu, Gwendolyn G Calhoon, Sarah A Halbert, Romy Wichmann, Stephanie S Holden, Kim L Mertens, Melodi Anahtar, Ada C Felix-Ortiz, Ian R Wickersham, Jesse M Gray, Kay M Tye
The ability to differentiate stimuli predicting positive or negative outcomes is critical for survival, and perturbations of emotional processing underlie many psychiatric disease states. Synaptic plasticity in the basolateral amygdala complex (BLA) mediates the acquisition of associative memories, both positive and negative. Different populations of BLA neurons may encode fearful or rewarding associations, but the identifying features of these populations and the synaptic mechanisms of differentiating positive and negative emotional valence have remained unknown...
April 30, 2015: Nature
Max-Philipp Stenner, Vladimir Litvak, Robb B Rutledge, Tino Zaehle, Friedhelm C Schmitt, Jürgen Voges, Hans-Jochen Heinze, Raymond J Dolan
The nucleus accumbens is thought to contribute to action selection by integrating behaviorally relevant information from multiple regions, including prefrontal cortex. Studies in rodents suggest that information flow to the nucleus accumbens may be regulated via task-dependent oscillatory coupling between regions. During instrumental behavior, local field potentials (LFP) in the rat nucleus accumbens and prefrontal cortex are coupled at delta frequencies (Gruber AJ, Hussain RJ, O'Donnell P. PLoS One 4: e5062, 2009), possibly mediating suppression of afferent input from other areas and thereby supporting cortical control (Calhoon GG, O'Donnell P...
July 2015: Journal of Neurophysiology
Mary Beth Calhoon, Yaacov Petscher
The purpose of this project was to examine group- and individual-level responses by struggling adolescents readers (6(th) - 8(th) grades; N = 155) to three different modalities of the same reading program, Reading Achievement Multi-Component Program (RAMP-UP). The three modalities differ in the combination of reading components (phonological decoding, spelling, fluency, comprehension) that are taught and their organization. Latent change scores were used to examine changes in phonological decoding, fluency, and comprehension for each modality at the group level...
April 2013: Reading and Writing
Catherine Calhoon, Stephanie Lehmann
No abstract text is available yet for this article.
December 2014: South Dakota Medicine: the Journal of the South Dakota State Medical Association
Catherine Calhoon
No abstract text is available yet for this article.
October 2014: South Dakota Medicine: the Journal of the South Dakota State Medical Association
John H Calhoon, Clint Baisden, Ben Holler, George L Hicks, Ed L Bove, Cameron D Wright, Walter H Merrill, Dave A Fullerton
BACKGROUND: We sought to define an accurate measure of thoracic surgical education costs. METHODS: Program directors from six distinct and differently sized and geographically located thoracic surgical training programs used a common template to provide estimates of resident educational costs. These data were reviewed, clarifying questions or discrepancies when noted and using best estimates when exact data were unavailable. Subsequently, a composite of previously published cost-estimation products was used to capture accurate cost data...
December 2014: Annals of Thoracic Surgery
Amanda L Eilers, Alia N Nazarullah, Edward S Shipper, Jaishree S Jagirdar, John H Calhoon, S Adil Husain
Although inflammatory myofibroblastic tumors (IMTs) can be found in virtually every major organ, cardiac origin is rare. After recently providing care to a child who presented with a significant myocardial infarction, interest in this rare tumor was piqued. We describe a comprehensive review of cardiac IMT, including information on nomenclature, epidemiology, clinical features, pathogenesis, gross/histological features, immunohistochemical profile, diagnosis, treatment, and prognosis. Fifty-seven cases were identified in the literature...
October 2014: World Journal for Pediatric & Congenital Heart Surgery
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