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Pseudomonas aeruginosa multidrug-resistant in childs

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https://www.readbyqxmd.com/read/27664282/multidrug-resistant-pseudomonas-aeruginosa-infection-in-a-child-with-cystic-fibrosis
#1
Jocelyn Y Ang, Nahed Abdel-Haq, Frank Zhu, Abrar K Thabit, David P Nicolau, Michael J Satlin, David van Duin
We describe a pediatric cystic fibrosis patient who developed a pulmonary exacerbation due to two multidrug-resistant (MDR) Pseudomonas aeruginosa isolates. In addition to these MDR organisms, the case was further complicated by β-lactam allergy. Despite the MDR phenotype, both isolates were susceptible to an antimicrobial combination.
October 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/25831667/multi-drug-resistant-pseudomonas-aeruginosa-a-threat-of-nosocomial-infections-in-tertiary-care-hospitals
#2
Zaheer Ali, Nusrat Mumtaz, Sehar Afshan Naz, Nusrat Jabeen, Maryam Shafique
OBJECTIVE: To determine the resistance patterns of Pseudomonas aeruginosa to currently available anti-pseudomonal drugs and frequency of nosocomial infections caused by multi drug resistant Pseudomonas aeruginosa in hospitals. METHODS: Clinical isolates of Pseudomonas aeruginosa were collected from patients admitted in different hospitals of Karachi between July 2012 and June 2013. The isolates were identified by conventional and Analytical Profile Index 20NE kit methods while the antibiograms of these isolates were determined by Kirby-Bauer disc diffusion method...
January 2015: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/25596115/molecular-epidemiological-survey-of-the-quinolone-and-carbapenem-resistant-genotype-and-its-association-with-the-type-iii-secretion-system-in-pseudomonas-aeruginosa
#3
Melina Lorraine Ferreira, Raquel Cavalcanti Dantas, Ana Luiza Souza Faria, Iara Rossi Gonçalves, Cristiane Silveira de Brito, Lícia Ludendorff Queiroz, Paulo P Gontijo-Filho, Rosineide Marques Ribas
This study evaluated the predictors of mortality and the impact of inappropriate therapy on the outcomes of patients with bacteraemia and ventilator-associated pneumonia (VAP). Additionally, we evaluated the correlation of the type III secretion system (TTSS) effector genotype with resistance to carbapenems and fluoroquinolones, mutations in the quinolone resistance-determining regions (QRDRs), metallo-β-lactamase and virulence factors. A retrospective cohort was conducted at a tertiary hospital in patients with multidrug-resistant (MDR) P...
March 2015: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/25420319/-evaluation-of-six-cases-of-arbekacin-inhalation-for-pneumonia
#4
Yukihiro Hamada, Hiroyuki Suematsu, Jun Hirai, Yuka Yamagishi, Hiroshige Mikamo
Arbekacin (ABK) is one of aminoglycosides which has indications for septicemia and pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA) in Japan. ABK shows good clinical and microbiological efficacies also against Gram-negative bacteria (GNB), including Pseudomonas aeruginosa. In addition, furthermore, ABK would be sometimes effective also against antimicrobial-resistant GNB. We investigated ABK inhalation, which showed good pulmonary drug delivery, for the treatment of pneumonia caused by multidrug-resistant Gram-negative organisms and MRSA...
August 2014: Japanese Journal of Antibiotics
https://www.readbyqxmd.com/read/25360190/risk-factors-for-wound-infection-in-health-care-facilities-in-buea-cameroon-aerobic-bacterial-pathogens-and-antibiogram-of-isolates
#5
Akoachere Jane-Francis Tatah Kihla, Palle John Ngunde, Mbianda Soupsop Evelyn, Nkwelang Gerard, Roland Ndip Ndip
INTRODUCTION: Wound infection is a significant clinical challenge in hospitals in developing countries where proper healthcare delivery is hampered by limited resources. This study investigated the antibiotic susceptibility pattern of bacteria causing wound infection and risk factors for infection among hospitalized patients in Buea, Cameroon, to generate findings which could drive reformation of policies on infection control. METHODS: Aerobic bacteria were isolated from 212 swabs collected from patients with clinically diagnosed infected wounds...
2014: Pan African Medical Journal
https://www.readbyqxmd.com/read/25261066/pseudomonas-aeruginosa-bacteraemia-independent-risk-factors-for-mortality-and-impact-of-resistance-on-outcome
#6
Raquel Cavalcanti Dantas, Melina Lorraine Ferreira, Paulo Pinto Gontijo-Filho, Rosineide Marques Ribas
The rates of multidrug-resistant, extensively drug-resistant and pandrug-resistant isolates amongst non-fermenting Gram-negative bacilli, particularly Pseudomonas aeruginosa, have risen worldwide. The clinical consequence of resistance and the impact of adverse treatment on the outcome of patients with P. aeruginosa bacteraemia remain unclear. To better understand the predictors of mortality, the clinical consequence of resistance and the impact of inappropriate therapy on patient outcomes, we analysed the first episode of P...
December 2014: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/25140768/-pathogenic-analysis-of-ventilator-associated-pneumonia-in-the-pediatric-intensive-care-unit-in-high-altitude-areas
#7
Yan-Liang Xia, Mei Ge, Zhen Wang
OBJECTIVE: To investigate the pathogens of ventilator-associated pneumonia (VAP) and their drug resistance in the pediatric intensive care unit (PICU) in high-altitude areas and to provide a clinical basis for the prevention and treatment of VAP. METHODS: A total of 94 children with VAP hospitalized in the PICU in high-altitude areas between June 2011 and June 2013 were recruited. Their lower respiratory tract secretions were collected for bacterial culture and drug sensitivity test...
August 2014: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/25102101/is-there-a-role-for-antimicrobial-stewardship-in-cystic-fibrosis
#8
Valerie J Waters, Felix A Ratjen
There is currently considerable interest in developing antimicrobial stewardship programs in pediatric and adult acute and chronic care hospitals as a method of preserving the activity of existing antimicrobial agents against an increasing number of multidrug-resistant organisms. Cystic fibrosis (CF) is recognized as one of the conditions associated with the highest use of antimicrobials in pediatrics and has thus been identified as a potential target of antimicrobial stewardship programs. The benefits of aggressive antibiotic use to treat pulmonary infections in individuals with CF are well defined and it is not always possible to follow the stewardship principle of narrowing antimicrobial spectrum based on susceptibility testing and treating with short antibiotic courses...
September 2014: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/25051279/predictors-of-7-and-30-day-mortality-in-pediatric-intensive-care-unit-patients-with-cancer-and-hematologic-malignancy-infected-with-gram-negative-bacteria
#9
Patrícia de Oliveira Costa, Elias Hallack Atta, André Ricardo Araujo da Silva
BACKGROUND: Infection with Gram-negative bacteria is associated with increased morbidity and mortality. The aim of this study was to evaluate the predictors of 7- and 30-day mortality in pediatric patients in an intensive care unit with cancer and/or hematologic diseases and Gram-negative bacteria infection. METHODS: Data were collected relating to all episodes of Gram-negative bacteria infection that occurred in a pediatric intensive care unit between January 2009 and December 2012, and these cases were divided into two groups: those who were deceased seven and 30 days after the date of a positive culture and those who survived the same time frames...
November 2014: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/24968040/-evolution-of-antimicrobial-resistance-in-gram-negative-bacilli-from-intensive-care-units-in-colombia
#10
Cristhian Hernández-Gómez, Víctor M Blanco, Gabriel Motoa, Adriana Correa, Marta Vallejo, María Virginia Villegas
INTRODUCTION: The continuous evolution of antimicrobial resistance poses a major threat to public health worldwide. Molecular biology techniques have been integrated to epidemiological surveillance systems to improve the control strategies of this phenomenon. OBJECTIVE: To describe the phenotypic and molecular profiles of the most important Gram negative bacilli from intensive care units in 23 Colombian hospitals during the study period 2009-2012. MATERIALS AND METHODS: A descriptive study was conducted in 23 hospitals belonging to the Colombian Nosocomial Resistance Study Group...
April 2014: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/24864033/a-survey-of-five-broad-host-range-plasmids-in-gram-negative-bacilli-isolated-from-patients
#11
Guo-qiang Zhang, Yi-hui Yao, Xiao-lu Yu, Jian-jun Niu
OBJECTIVES: To learn the prevalence of the primary classical broad-host-range (BHR) IncA/C, IncN, IncP, IncQ, and IncW plasmids in dominant gram-negative bacilli from inpatients in a teaching hospital in southern China. METHODS: A multiplex polymerase chain reaction based on the replicons of BHR IncA/C, IncN, IncP, IncQ, and IncW plasmids was developed and used to determine these BHR plasmids. The difference in prevalence rates among the different species from three specimens was evaluated by a binary logistic regression model and the differences between multidrug-resistant organisms (MDRO) and non-MDRO were assessed using a chi-square test...
July 2014: Plasmid
https://www.readbyqxmd.com/read/24642515/epidemiology-and-clinical-outcomes-of-multidrug-resistant-gram-negative-bloodstream-infections-in-a-european-tertiary-pediatric-hospital-during-a-12-month-period
#12
Laura Folgori, Susanna Livadiotti, Michaela Carletti, Julia Bielicki, Giuseppe Pontrelli, Marta Luisa Ciofi Degli Atti, Chiara Bertaina, Barbara Lucignano, Stefania Ranno, Edoardo Carretto, Maurizio Muraca, Mike Sharland, Paola Bernaschi
BACKGROUND: Bloodstream infections caused by multidrug-resistant, Gram-negative (MDRGN) bacteria represent a significant cause of morbidity and mortality. Prompt diagnosis and appropriate empiric treatment are the most important determinants of patient outcome. The objective of our study was to assess the epidemiology and clinical outcome of MDRGN sepsis in a tertiary-care pediatric hospital during a 12-month period. METHODS: It was a retrospective, observational study of MDRGN bacteremia including all patients <18 years of age, hospitalized during 2011, with documented bacteremia caused by Enterobacteriaceae or non-fermentative bacteria...
September 2014: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/24513132/diversity-of-%C3%AE-lactamases-produced-by-imipenem-resistant-pseudomonas-aeruginosa-isolates-from-the-bloodstream
#13
Shahin Najar Peerayeh, Rahim Pirhajati Mahabadi, Sanaz Pakbaten Toupkanlou, Seyed Davar Siadat
INTRODUCTION: The emergence of imipenem non-susceptible Pseudomonas aeruginosa isolates is a matter of great concern because these isolates can become resistant to all available antibiotics. This study conducted to characterize β-lactamase genes in imipenem resistant P. aeruginosa isolates from bloodstream. METHODS: 56 non-duplicate clinical isolates of P. aeruginosa were collected in Tehran hospitals. Antibacterial susceptibility was determined by disk diffusion and MIC methods...
November 2014: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/24501388/treatment-of-multidrug-resistant-gram-negative-infections-in-children
#14
REVIEW
Alice J Hsu, Pranita D Tamma
Antibiotic resistance in conjunction with the erosion of the drug development pipeline may lead us into a bleak future, a "post-antibiotic era." Because of a shortage of studies addressing treatment options for multidrug-resistant Gram-negative (MDRGN) infections in children, data must be extrapolated from the adult literature. However, even adult studies are limited by significant methodological flaws. We are in urgent need of pediatric specific pharmacokinetic/pharmacodynamic data for agents with activity against MDRGN infections as well as improved clinical outcomes studies...
May 2014: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/24346607/the-use-of-colistin-in-critically-ill-children-in-a-pediatric-intensive-care-unit
#15
Adem Karbuz, Halil Özdemir, Ayhan Yaman, Bilge Aldemir Kocabaş, Çağlar Odek, Haluk Güriz, Ahmet Derya Aysev, Ergin Çiftçi, Tanil Kendirli, Can Ateş, Erdal İnce
BACKGROUND: Colistin is active against most multidrug-resistant, aerobic Gram-negative bacteria. Because of the reported nephrotoxicity during the first years of use of colistin, there were concerns of its use in pediatrics where there was limited experience The aim of this study is to document the clinical characteristics and outcomes of use of colistin in pediatric patients at a pediatric intensive care unit in Turkey. METHODS: We reviewed the medical and laboratory records of 29 critically ill children who were treated with colistin for 38 courses between January 2011 and December 2011 at the Department of Pediatric Intensive Care Unit in Ankara University Medical School, Turkey...
January 2014: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/24256585/-surveillance-of-bacterial-distribution-and-drug-resistance-in-inpatients-with-surgical-infections-a-single-center-study
#16
Ke-wei Jiang, You Lü, Peng Guo, Ying-jiang Ye, Hui Wang, Qi Wang, Chun-jiang Zhao, Zhi-dong Gao, Jian Cao, Liang Lü, Yi-chao Yan, Shan Wang
OBJECTIVE: To investigate the bacterial distribution and drug resistance in patients with surgical infections, and provide the basis for the standardization treatment of the surgical infection. METHODS: Retrospectively analyzed from January 2008 to December 2011 surgical infection in our samples bacteria identification and drug sensitivity test results. RESULTS: A total of 3829 nonduplicate isolates from 3257 samples, Gram-negative bacteria accounted for 62...
July 2013: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/24170687/a-retrospective-study-on-the-effects-of-colistin-therapy-in-children-with-multidrug-resistant-gram-negative-bacterial-pathogens-impact-of-hiv-status-on-outcome
#17
Konstantinos Dimitriades, Brenda May Morrow, Prakash Jeena
BACKGROUND: Nosocomially acquired multidrug-resistant (MDR) Gram-negative bacteria are important contributors to paediatric intensive care unit (PICU) mortality and morbidity, with limited treatment options. AIM: To investigate the outcomes of all children treated with colistin for infection with MDR Gram-negative bacteria while admitted to PICU. METHODS: Retrospective observational study of 19 months. Primary endpoints were all-cause intensive care unit mortality and safety...
March 2014: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/24029199/colistin-re-emergence-of-the-forgotten-antimicrobial-agent
#18
REVIEW
A K Dhariwal, M S Tullu
The treatment of the emerging multidrug resistant (MDR) gram-negative organisms is a challenge. The development of newer antibiotics has recently slowed down. This has led to the re-emergence of the 'old forgotten' antibiotic "Colistin", whose use had almost stopped (after 1970's) due to the high incidence of nephrotoxicity and neurotoxicity. Colistin (polymyxin E) is a polypeptide antibiotic belonging to polymyxin group of antibiotics with activity mainly against the gram-negative organisms. Use of colistin has been increasing in the recent past and newer studies have shown lesser toxicity and good efficacy...
July 2013: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/24016648/-health-care-associated-multidrug-resistant-bacteria-in-a-pediatric-hospital-five-year-experience
#19
Patrícia Mação, João Casalta Lopes, Henrique Oliveira, Guiomar Oliveira, Fernanda Rodrigues
INTRODUCTION: In recent years there has been an increase of infections caused by multidrug-resistant bacteria. Paediatric data are scarce, particularly at national level. AIMS: To analyse trends of health-care associated multidrug-resistant bacteria infections in a paediatric hospital. MATERIAL AND METHODS: A retrospective incidence study was conducted in medical, surgical and intensive care wards in a level III paediatric hospital, from January 2005 to December 2009...
July 2013: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/23845533/spread-of-extensively-resistant-vim-2-positive-st235-pseudomonas-aeruginosa-in-belarus-kazakhstan-and-russia-a-longitudinal-epidemiological-and-clinical-study
#20
Mikhail V Edelstein, Elena N Skleenova, Oksana V Shevchenko, Jimson W D'souza, Dmitry V Tapalski, Ilya S Azizov, Marina V Sukhorukova, Roman A Pavlukov, Roman S Kozlov, Mark A Toleman, Timothy R Walsh
BACKGROUND: Multidrug-resistant and extensively-drug-resistant Pseudomonas aeruginosa are increasing therapeutic challenges worldwide. We did a longitudinal epidemiological and clinical study of extensively-drug-resistant P aeruginosa in Belarus, Kazakhstan, and Russia. METHODS: The study was done in three prospectively defined phases: Jan 1, 2002-Dec 31, 2004; Jan 1, 2006-Dec 31, 2007; and Jan 1, 2008-Dec 31, 2010. The first two phases were in Russia only. All consecutive, non-duplicate, nosocomial isolates and case report forms were sent to the coordinating centre (Institute of Antimicrobial Chemotherapy, Smolensk, Russia), where species reidentification, susceptibility testing, and molecular typing of isolates were done...
October 2013: Lancet Infectious Diseases
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