keyword
MENU ▼
Read by QxMD icon Read
search

Hpv screening and diagnostic

keyword
https://www.readbyqxmd.com/read/28622890/evaluation-of-type-specific-antibodies-to-high-risk-human-papillomavirus-hpv-proteins-in-patients-with-oropharyngeal-cancer
#1
Martina A Broglie, Wolfram Jochum, Angelika Michel, Tim Waterboer, Diana Foerbs, René Schoenegg, Sandro J Stoeckli, Michael Pawlita, Dana Holzinger
OBJECTIVES: High risk human papillomavirus (HR-HPV) infection leads to a subgroup of oropharyngeal cancer (OPSCC) characterized by improved treatment response. However an universally accepted definition of an HR-HPV-attributable cancer is lacking. METHODS: Detailed, type-specific HPV antibody responses were analyzed by multiplex serology in HR-HPV-attributable OPSCC patients, defined by p16(INK4A) overexpression and HR-HPV DNA detection by PCR amplification and sequencing...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28606721/why-does-cervical-cancer-occur-in-a-state-of-the-art-screening-program
#2
Philip E Castle, Walter K Kinney, Li C Cheung, Julia C Gage, Barbara Fetterman, Nancy E Poitras, Thomas S Lorey, Nicolas Wentzensen, Brian Befano, John Schussler, Hormuzd A Katki, Mark Schiffman
BACKGROUND: The goal of cervical screening is to detect and treat precancers before some become cancer. We wanted to understand why, despite state-of-the-art methods, cervical cancers occured in relationship to programmatic performance at Kaiser Permanente Northern California (KPNC), where >1,000,000 women aged ≥30years have undergone cervical cancer screening by triennial HPV and cytology cotesting since 2003. METHODS: We reviewed clinical histories preceding cervical cancer diagnoses to assign "causes" of cancer...
June 10, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28565927/human-papilloma-virus-associated-lips-verrucous-carcinoma-in-hiv-infected-male
#3
Giuseppe Vittorio De Socio, Olena Bidovanets, Gian Marco Tomassini, Luca Fanelli, Stefano Simonetti
Human papillomavirus (HPV) infection, widely known as the necessary cause of cervical cancer, has been established as a major etiologic factor for head and neck cancer (HNC). HIV-infected individuals are at higher risk of HPV-associated cancers than the general population. We describe a 45-year-old man with HIV and HPV coinfection, who presented progressively enlarging verrucous neoformations of the lips. The final diagnosis of verrucous carcinoma was delayed. Early detection of HPV lesions in oral mucosa and HPV screening activities could be important in improving the diagnostic sensitivity for the HIV-infected patients with oral cancer...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28515214/assessment-of-a-new-lower-cost-real-time-pcr-detection-assay-for-high-risk-hpv-useful-for-cervical-screening-in-limited-resource-settings
#4
Joel Fokom Domgue, Mark Schiffman, Nicolas H Wentzensen, Julia C Gage, Philip E Castle, Tina R Raine-Bennett, Barbara Fetterman, Thomas Lorey, Nancy E Poitras, Brian Befano, Yi Xie, Lais S Miachon, Michael Dean
Background Inexpensive and easy-to-perform HPV tests are needed for primary cervical cancer screening in lower-resource regions.Methods In a convenience sample of 516 residual exfoliative cervical specimens from the Kaiser Permanente Northern California and US National Cancer Institute Persistence and Progression study, we compared agreement and clinical performance of a simple, inexpensive real-time PCR assay for detection of 13 carcinogenic HPV types (H13, Hybribio, Hong Kong) that is marketed in limited resource settings, to previous testing by HC2 (Qiagen, Germantown, MD) and Onclarity (BD Diagnostics, Sparks, MD)...
May 17, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28440976/diagnostic-value-of-the-caretm-hpv-test-in-screening-for-cervical-intraepithelial-neoplasia-grade-2-or-worse
#5
Mojgan Karimi Zarchi, Effat Heydari, Afsarolsadat Tabatabaie, Mansour Moghimi, Wesam Kooti
Background: Cervical cancer is the fourth leading cause of cancer death in women worldwide. Persistent infection with a high risk human papillomavirus (HR-HPV) is the main etiological factor, so that early early detection of HR-HPV is very important. The aim of this study was to investigate the efficacy of CareTM HPV, a new method, as compared with Pap smear, PCR, and biopsy for screening purposes. Material and Method: In this cross-sectional study, 200 sexually active women aging from 25-50 years referred to the oncology clinic of Shahid Sodoughi Yazd Hospital in 2015 with a variety of cervix epithelial lesions or a need for colposcopy were enrolled...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28404551/endocervical-gastric-type-adenocarcinoma-an-unrelated-hpv-tumour-difficulties-in-screening-and-diagnosis
#6
Priscila Carneiro Lima, Julio Teixeira, Guilherme Nogueira Aires, Liliana De Angelo Andrade
Gastric-type adenocarcinoma of the cervix (GAS) is an uncommon and aggressive tumour unrelated to human papillomavirus (HPV) infection with distinctive histological and immunohistochemical characteristics. GAS may be associated with lobular endocervical glandular hyperplasia (LEGH), another unusual lesion. We report a case of a 59-year-old woman with screening cytology 'AGC-Neo' and cervical conisation exhibiting cervical intraepithelial neoplasia grade 1, extensive LEGH and canal sampling with abundant mucinous cells...
April 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28367025/role-of-p16-ink4a-and-ki-67-as-specific-biomarkers-for-cervical-intraepithelial-neoplasia-an-institutional-study
#7
Ankitha Hebbar, Venkataramappa Srinivasa Murthy
BACKGROUND: P16/INK4a and Ki-67 have emerged as important biomarkers for the detection of high-risk human papilloma virus (HR-HPV) associated dysplastic changes in the cervical biopsy samples. The increasing inter- and intra-observer variability in the diagnosis of dysplastic lesions and immature squamous metaplasia on histopathology has led to the advent of these biomarkers. This study was taken up with an aim to study their role in increasing the diagnostic accuracy in equivocal cases on histopathology...
April 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28337594/diagnostic-accuracy-of-high-risk-hpv-dna-genotyping-for-primary-cervical-cancer-screening-and-triage-of-hpv-positive-women-compared-to-cytology-preliminary-results-of-the-pipavir-study
#8
Kimon Chatzistamatiou, Theodoros Moysiadis, Eleftherios Angelis, Andreas Kaufmann, Alkmini Skenderi, Pidder Jansen-Duerr, Irini Lekka, Vasilis Kilintzis, Stamatia Angelidou, Evangelia Katsiki, Ingke Hagemann, Athena Tsertanidou, Isabel Koch, Oliver Boecher, Erwin Soutschek, Nikolaos Maglaveras, Theodoros Agorastos
PURPOSE: The purpose of the presented PIPAVIR (persistent infections with human papillomaviruses; http://www.pipavir.com ) subanalysis is to assess the performance of high-risk (hr) HPV-DNA genotyping as a method of primary cervical cancer screening and triage of HPV positive women to colposcopy compared to liquid-based cytology (LBC) in an urban female population. METHODS: Women, aged 30-60, provided cervicovaginal samples at the Family-Planning Centre, Hippokratio Hospital of Thessaloniki, Greece, and the Department of Gynecology and Obstetrics in Mare Klinikum, Kiel, Germany...
May 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28279262/considerations-for-hpv-primary-screening-in-lower-middle-income-countries
#9
Mauricio Maza, Julia C Gage
The accumulated scientific evidence now provides ample support for HPV primary screening as a superior method for detecting cervical precancer and preventing cervical cancer. Approximately half of the global burden of cervical cancer could be reduced in lower-middle income countries where attempts to implement traditional cytology-based programs have not experienced successes. In these countries screening programs have struggled with poor screening and diagnostic test sensitivity, difficulties maintaining quality control and adequate population coverage...
May 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28279257/approaches-for-triaging-women-who-test-positive-for-human-papillomavirus-in-cervical-cancer-screening
#10
Joseph E Tota, James Bentley, Jennifer Blake, François Coutlée, Máire A Duggan, Alex Ferenczy, Eduardo L Franco, Michael Fung-Kee-Fung, Walter Gotlieb, Marie-Hélène Mayrand, Meg McLachlin, Joan Murphy, Gina Ogilvie, Sam Ratnam
Substantial evidence exists to support the introduction of molecular testing for human papillomavirus (HPV) as the primary technology in cervical cancer screening. While HPV testing is much more sensitive than cytology for detection of high-grade precancerous lesions, it is less specific. To improve efficiency, it is therefore recommended that a specific test (like cytology) be used in triaging HPV positive women to colposcopy. A number of studies have been conducted that support the use of cytology alone or in conjunction with HPV genotyping for triage...
May 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28223432/performance-and-diagnostic-accuracy-of-a-urine-based-human-papillomavirus-assay-in-a-referral-population
#11
Jack M Cuzick, Louise Cadman, Amar Sabri Ahmad, Linda Ho, George Terry, Michelle Kleeman, Deirdre Lyons, Janet Austin, Mark H Stoler, Cecile Rose T Vibat, Janel Dockter, David Robbins, Paul R Billings, Mark G Erlander
Background HPV testing from clinician-collected cervical and self-collected cervico-vaginal samples is more sensitive for detecting CIN2+/CIN3+ than cytology-based screening, stimulating interest in HPV testing from urine. The objective was to determine the performance of the Trovagene HPV test for the detection of CIN2+ from urine and PreservCyt cervical samples. Methods Women referred for colposcopy at St Mary's Hospital London, following abnormal cytology, were recruited to this diagnostic accuracy study by convenience sampling (September 2011 and April 2013)...
February 21, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28161277/comparison-of-the-abbott-realtime-high-risk-hpv-test-and-the-roche-cobas-4800-hpv-test-using-urine-samples
#12
Myong Cheol Lim, Do-Hoon Lee, Sang-Hyun Hwang, Na Rae Hwang, Bomyee Lee, Hye Young Shin, Jae Kwan Jun, Chong Woo Yoo, Dong Ock Lee, Sang-Soo Seo, Sang-Yoon Park, Jungnam Joo
BACKGROUND: Human papillomavirus (HPV) testing based on cervical samples is important for use in cervical cancer screening. However, cervical sampling is invasive. Therefore, non-invasive methods for detecting HPV, such as urine samples, are needed. OBJECTIVES: For HPV detection in urine samples, two real-time PCR (RQ-PCR) tests, Roche cobas 4800 test (Roche_HPV; Roche Molecular Diagnostics) and Abbott RealTime High Risk HPV test (Abbott_HPV; Abbott Laboratories) were compared to standard cervical samples...
May 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28125861/immediate-referral-to-colposcopy-versus-cytological-surveillance-for-minor-cervical-cytological-abnormalities-in-the-absence-of-hpv-test
#13
REVIEW
Maria Kyrgiou, Ilkka E J Kalliala, Anita Mitra, Christina Fotopoulou, Sadaf Ghaem-Maghami, Pierre Pl Martin-Hirsch, Margaret Cruickshank, Marc Arbyn, Evangelos Paraskevaidis
BACKGROUND: A significant number of women are diagnosed with minor cytological abnormalities on cervical screening. Many authorities recommend surveillance as spontaneous regression might occur. However, attendance for cytological follow-up decreases with time and might put some women at risk of developing invasive disease. OBJECTIVES: To assess the optimum management strategy for women with minor cervical cytological abnormalities (atypical squamous cells of undetermined significance - ASCUS or low-grade squamous intra-epithelial lesions - LSIL) at primary screening in the absence of HPV (human papillomavirus) DNA test...
January 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28102928/reduction-in-colposcopy-workload-and-associated-clinical-activity-following-human-papillomavirus-hpv-catch-up-vaccination-programme-in-scotland-an-ecological-study
#14
M E Cruickshank, J Pan, S C Cotton, K Kavanagh, C Robertson, K Cuschieri, H Cubie, T Palmer, K G Pollock
OBJECTIVE: To measure patterns of clinical activity at colposcopy before and after vaccinated women entered the Scottish Cervical Screening Programme (SCSP). DESIGN: Population-based observational study using nationally collected data. SETTING: Scottish colposcopy clinics. SAMPLE: All women with a date of birth on or after 1 January 1985 who attended colposcopy in Scotland between 2008 and 2014. METHODS: Routinely collected data from the Scottish National Colposcopy Clinical Information Audit System (NCCIAS) were extracted, including: referral criteria, referral cervical cytology, colposcopic findings, clinical procedures, and histology results...
January 19, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28094038/triaging-hpv-positive-women-with-p16-ki-67-dual-stained-cytology-results-from-a-sub-study-nested-into-the-athena-trial
#15
Thomas C Wright, Catherine M Behrens, James Ranger-Moore, Susanne Rehm, Abha Sharma, Mark H Stoler, Ruediger Ridder
OBJECTIVES: In addition to genotyping for HPV16/18, dual-immunostaining for p16/Ki-67 has shown promise as a triage of HPV-positive women. We assessed the performance of p16/Ki-67 dual-stained cytology for triaging HPV-positive women undergoing primary HPV screening. METHODS: All women ≥25years with valid cervical biopsy and cobas® HPV Test results from the cross-sectional phase of ATHENA who were referred to colposcopy (n=7727) were eligible for enrolment. p16/Ki-67 dual-stained cytology was retrospectively performed on residual cytologic material collected into a second liquid-based cytology vial during the ATHENA enrolment visit...
January 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/27993884/misdiagnosis-analysis-of-cervical-minimal-deviation-adenocarcinoma-a-report-of-three-rare-cases-and-literature-review
#16
REVIEW
Mingxing Sui, Yanling Pei, Dong Li, Qiaori Li, Peining Zhu, Tianmin Xu, Manhua Cui
Cervical minimal deviation adenocarcinoma (MDA) is a rare variant of cervical adenocarcinoma that is difficult to diagnose due to the deep location, endogenous growth pattern, deceptively benign appearance of tumor cells, and lack of connection to human papillomavirus (HPV). Cytological evaluation and biopsies offer suboptimal detection and transvaginal sonography or Magnetic Resonance Imaging (MRI) only reveal multiple lesions that mimic multiple benign nabothian cysts. Besides, standard screening, diagnostic tools, and treatments are not established...
December 2016: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/27922858/hiv-hpv-and-microbiota-partners-in-crime
#17
Sergio Serrano-Villar, Emilia Vásquez-Domínguez, José Antonio Pérez-Molina, Talía Sainz, Amparo de Benito, Amparo Latorre, Andrés Moya, María José Gosalbes, Santiago Moreno
Altered interplay between gut mucosa and dysbiotic bacteria during HIV infection seems to fuel chronic immune dysfunction and might explain the excess rates of human papillomavirus (HPV)-associated anal cancer in HIV-infected individuals. Here, we show in HIV-infected MSM undergoing screening for HPV-related cancer that specific fecal and mucosal bacteria are able to predict the existence of precancerous anal lesions. If confirmed, these bacterial biomarkers could be exploited either as diagnostic tools or therapeutic targets...
February 20, 2017: AIDS
https://www.readbyqxmd.com/read/27826568/pax1-and-sox1-methylation-as-an-initial-screening-method-for-cervical-cancer-a-meta-analysis-of-individual-studies-in-asians
#18
Yan Chen, Zhaolei Cui, Zhenzhou Xiao, Minhua Hu, Chuanhui Jiang, Yingying Lin, Yansong Chen
BACKGROUND: Epigenetic alterations of gene or DNA methylation have been highlighted as promising biomarkers for early cervical cancer screening. Herein, we evaluated the diagnostic performance of paired boxed gene 1 (PAX1) and sex determining region Y-box 1 (SOX1) methylation for cervical cancer detection. METHODS: Eligible studies were retrieved by searching the electronic databases. Study quality was assessed according to the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) checklist...
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27821079/comparison-of-dna-testing-strategies-in-monitoring-human-papillomavirus-infection-prevalence-through-simulation
#19
COMPARATIVE STUDY
Carol Y Lin, Ling Li
BACKGROUND: HPV DNA diagnostic tests for epidemiology monitoring (research purpose) or cervical cancer screening (clinical purpose) have often been considered separately. Women with positive Linear Array (LA) polymerase chain reaction (PCR) research test results typically are neither informed nor referred for colposcopy. Recently, a sequential testing by using Hybrid Capture 2 (HC2) HPV clinical test as a triage before genotype by LA has been adopted for monitoring HPV infections. Also, HC2 has been reported as a more feasible screening approach for cervical cancer in low-resource countries...
November 7, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27816947/external-quality-assessment-for-human-papillomavirus-16-18-dna-detection-and-genotyping-in-shanghai-china
#20
Xueliang Wang, Fen Liu, Lingli Jiang, Yun Bao, Yanqun Xiao, Hualiang Wang
BACKGROUND: Human papillomavirus (HPV) DNA detection and genotyping is now being used for cervical screening by a growing number of laboratories in Shanghai, but they may have various levels of proficiency. The objective of this study was to evaluate the performance of clinical laboratories for HPV DNA detection and genotyping by an external quality assessment (EQA) program. METHODS: The EQA panels were clinically validated by the Cobas 4800 HPV test, and then distributed to the participating laboratories in May 2015 (round 1) and September 2015 (round 2)...
February 1, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
keyword
keyword
83602
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"