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https://www.readbyqxmd.com/read/28734857/comorbidities-in-difficult-to-control-asthma
#1
Pieter-Paul W Hekking, Marijke Amelink, Reinier R Wener, Marcel L Bouvy, Elisabeth H Bel
BACKGROUND: Difficult-to-control asthma is associated with significant medical and financial burden. Comorbidities are known to contribute to uncontrolled asthma. Better insight into the prevalence, nature, and risk factors of comorbidities may optimize treatment strategies in patients with difficult-to-control asthma and decrease disease burden. OBJECTIVES: The objectives of this study were to assess the prevalence, number, and type of comorbidities in difficult-to-control asthma compared with not-difficult-to-control asthma, and to investigate whether specific patient characteristics are associated with particular comorbidities...
July 19, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28732461/a-deep-convolutional-neural-network-approach-to-single-particle-recognition-in-cryo-electron-microscopy
#2
Yanan Zhu, Qi Ouyang, Youdong Mao
BACKGROUND: Single-particle cryo-electron microscopy (cryo-EM) has become a mainstream tool for the structural determination of biological macromolecular complexes. However, high-resolution cryo-EM reconstruction often requires hundreds of thousands of single-particle images. Particle extraction from experimental micrographs thus can be laborious and presents a major practical bottleneck in cryo-EM structural determination. Existing computational methods for particle picking often use low-resolution templates for particle matching, making them susceptible to reference-dependent bias...
July 21, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28732302/a-familiar-size-stroop-effect-in-the-absence-of-basic-level-recognition
#3
Bria Long, Talia Konkle
When we view a picture of an object, we automatically recognize what the object is and know how big it typically is in the world (Konkle & Oliva, 2012). Is information about an object's size activated only after we've identified the object, or can this size information be activated before object recognition even occurs? We previously found that big and small objects differ in mid-level perceptual features (Long, Konkle, Cohen, & Alvarez, 2016). Here we asked whether these perceptual features can automatically trigger real-world size processing, bypassing the need for basic-level object recognition...
July 18, 2017: Cognition
https://www.readbyqxmd.com/read/28732233/piecewise-convexity-of-artificial-neural-networks
#4
Blaine Rister, Daniel L Rubin
Although artificial neural networks have shown great promise in applications including computer vision and speech recognition, there remains considerable practical and theoretical difficulty in optimizing their parameters. The seemingly unreasonable success of gradient descent methods in minimizing these non-convex functions remains poorly understood. In this work we offer some theoretical guarantees for networks with piecewise affine activation functions, which have in recent years become the norm. We prove three main results...
July 3, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28731445/colivelin-ameliorates-impairments-in%C3%A2-cognitive-behaviors-and-synaptic-plasticity-in-app-ps1-transgenic-mice
#5
Meina Wu, Hui Shi, Yexin He, Li Yuan, Xuesong Qu, Jun Zhang, Zhaojun Wang, Hongyan Cai, Jinshun Qi
Alzheimer's disease (AD) is the most common cause of dementia, and effective therapeutics are lacking. Colivelin (CLN), a novel, strong humanin derivative, is effective in vitro in preventing cell death induced by AD-causative genes and amyloid-β protein (Aβ) even at a low concentration. We recently demonstrated that intrahippocampal injection of CLN prevents Aβ25-35-induced deficits in spatial memory and synaptic plasticity in normal rats. Here, we further observed the effects of chronically intranasally (i...
July 19, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28729128/rosettes-engrailed-edges-and-star-shaped-patterns-between-rediscovery-and-forgetfulness-in-the-early-accounts-of-vibrating-liquid-drops-floating-over-hot-surfaces
#6
Seán M Stewart
Small drops of liquid brought into contact with very hot surfaces float above it as beautiful, slightly flattened spheroids without coming to the boil. An example of film boiling, drops that are sessile can often suddenly and quite unexpectedly start to oscillate forming highly symmetric patterns of surprising pulchritude. The rim of these oscillating drops take on "star-shaped" patterns with many different modes of vibration possible. Still an object of study today, their discovery, early accounts, rediscovery and ensuing controversies over claims of priority, before quietly slipping away from the collective memory of the scientific community to become all but forgotten makes for a compelling story in the early history of film boiling...
July 17, 2017: Endeavour
https://www.readbyqxmd.com/read/28724688/dopamine-d1-receptor-activation-leads-to-object-recognition-memory-in-a-coral-reef-fish
#7
Trevor J Hamilton, Martin Tresguerres, David I Kline
Object recognition memory is the ability to identify previously seen objects and is an adaptive mechanism that increases survival for many species throughout the animal kingdom. Previously believed to be possessed by only the highest order mammals, it is now becoming clear that fish are also capable of this type of memory formation. Similar to the mammalian hippocampus, the dorsolateral pallium regulates distinct memory processes and is modulated by neurotransmitters such as dopamine. Caribbean bicolour damselfish (Stegastes partitus) live in complex environments dominated by coral reef structures and thus likely possess many types of complex memory abilities including object recognition...
July 2017: Biology Letters
https://www.readbyqxmd.com/read/28723578/convolutional-neural-network-based-encoding-and-decoding-of-visual-object-recognition-in-space-and-time
#8
REVIEW
K Seeliger, M Fritsche, U Güçlü, S Schoenmakers, J-M Schoffelen, S E Bosch, M A J van Gerven
Representations learned by deep convolutional neural networks (CNNs) for object recognition are a widely investigated model of the processing hierarchy in the human visual system. Using functional magnetic resonance imaging, CNN representations of visual stimuli have previously been shown to correspond to processing stages in the ventral and dorsal streams of the visual system. Whether this correspondence between models and brain signals also holds for activity acquired at high temporal resolution has been explored less exhaustively...
July 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/28719614/beat-id-towards-a-computationally-low-cost-single-heartbeat-biometric-identity-check-system-based-on-electrocardiogram-wave-morphology
#9
Joana S Paiva, Duarte Dias, João P S Cunha
In recent years, safer and more reliable biometric methods have been developed. Apart from the need for enhanced security, the media and entertainment sectors have also been applying biometrics in the emerging market of user-adaptable objects/systems to make these systems more user-friendly. However, the complexity of some state-of-the-art biometric systems (e.g., iris recognition) or their high false rejection rate (e.g., fingerprint recognition) is neither compatible with the simple hardware architecture required by reduced-size devices nor the new trend of implementing smart objects within the dynamic market of the Internet of Things (IoT)...
2017: PloS One
https://www.readbyqxmd.com/read/28718781/latent-variable-method-for-automatic-adaptation-to-background-states-in-motor-imagery-bci
#10
Nikolay Dagaev, Ksenia Volkova, Alexei Ossadtchi
<i>Objective</i>. Brain-computer interface (BCI) systems are known to be vulnerable to variabilities in background states of a user. Usually, no detailed information on these states is available even during the training stage. Thus there is a need in a method which is capable of taking background states into account in an unsupervised way. <i>Approach</i>. We propose a latent variable method that is based on a probabilistic model with a discrete latent variable. In order to estimate the model's parameters, we suggest to use the expectation maximization (EM) algorithm...
July 18, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28715454/reduction-of-cav1-3-channels-in-dorsal-hippocampus-impairs-the-development-of-dentate-gyrus-newborn-neurons-and-hippocampal-dependent-memory-tasks
#11
Su-Hyun Kim, Ye-Ryoung Park, Boyoung Lee, Byungil Choi, Hyun Kim, Chong-Hyun Kim
Cav1.3 has been suggested to mediate hippocampal neurogenesis of adult mice and contribute to hippocampal-dependent learning and memory processes. However, the mechanism of Cav1.3 contribution in these processes is unclear. Here, roles of Cav1.3 of mouse dorsal hippocampus during newborn cell development were examined. We find that knock-out (KO) of Cav1.3 resulted in the reduction of survival of newborn neurons at 28 days old after mitosis. The retroviral eGFP expression showed that both dendritic complexity and the number and length of mossy fiber bouton (MFB) filopodia of newborn neurons at ≥ 14 days old were significantly reduced in KO mice...
2017: PloS One
https://www.readbyqxmd.com/read/28714886/non-convex-sparse-and-low-rank-based-robust-subspace-segmentation-for-data-mining
#12
Wenlong Cheng, Mingbo Zhao, Naixue Xiong, Kwok Tai Chui
Parsimony, including sparsity and low-rank, has shown great importance for data mining in social networks, particularly in tasks such as segmentation and recognition. Traditionally, such modeling approaches rely on an iterative algorithm that minimizes an objective function with convex l₁-norm or nuclear norm constraints. However, the obtained results by convex optimization are usually suboptimal to solutions of original sparse or low-rank problems. In this paper, a novel robust subspace segmentation algorithm has been proposed by integrating lp-norm and Schatten p-norm constraints...
July 15, 2017: Sensors
https://www.readbyqxmd.com/read/28713906/chronic-administration-of-sumo%C3%A2-1-has-negative-effects-on-novel-object-recognition-memory-as-well-as-cell-proliferation-and-neuroblast-differentiation-in-the-mouse-dentate-gyrus
#13
Dae Young Yoo, Dae Won Kim, Hyun Jung Kwon, Hyo Young Jung, Sung Min Nam, Jong Whi Kim, Jin Young Chung, Moo-Ho Won, Yeo Sung Yoon, Soo Young Choi, In Koo Hwang
Post‑translational modifications have been associated with developmental and aging processes, as well as in the pathogenesis of certain diseases. The present study aimed to investigate the effects of small ubiquitin‑like modifier 1 (SUMO‑1) on hippocampal dependent memory function, cell proliferation and neuroblast differentiation. To facilitate the delivery of SUMO‑1 into hippocampal neurons, a transactivator of transcription (Tat)‑SUMO‑1 fusion protein was constructed and mice were divided into two groups: A vehicle (Tat peptide)‑treated group and a Tat‑SUMO‑1‑treated group...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28713445/the-role-of-attitudes-to-and-the-frequency-of-domestic-violence-encounters-in-the-healthcare-professionals-handling-of-domestic-violence-cases
#14
Saša Zorjan, Urška Smrke, Lilijana Šprah
BACKGROUND: Domestic violence is recognized as a public health problem with a high prevalence in the general population. Healthcare professionals play an important role in the recognition and treatment of domestic violence. Hence, conducting research on factors that facilitate or inhibit appropriate actions by healthcare professionals is of the upmost importance. The objective of the study was to examine the relationship between healthcare professionals' attitudes toward the acceptability of domestic violence and their responses when dealing with victims of domestic violence...
September 2017: Zdravstveno Varstvo
https://www.readbyqxmd.com/read/28711394/exercise-prevents-ifn-%C3%AE-induced-mood-and-cognitive-dysfunction-and-increases-bdnf-expression-in-the-rat
#15
Charlotte K Callaghan, Jennifer Rouine, Shane M O'Mara
Aerobic exercise has marked effects on mood and cognition. Here, we used an interferon-alpha (IFN-α) induced depression model to evaluate the potential efficacy of chronic treadmill running on mood and cognition in the rat. IFN-α treatment induces behavioral deficits in the forced swim test (FST), open field test and object exploration task. Male han Wistar rats (n=8 per group, 3month old) were injected 3 times weekly with recombinant human IFN-α or saline (control) for 4weeks. One group was exercised 3 times (1h treadmill running) per week while the other remained sedentary...
July 12, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28706383/a-clinico-pathological-study-of-lupus-nephritis-based-on-the-international-society-of-nephrology-renal-pathology-society-2003-classification-system
#16
Suchitha Satish, Pallavi Deka, Manjunath Sanjeev Shetty
INTRODUCTION: Lupus nephritis (LN) is a major complication of systemic lupus erythematosus (SLE). Renal involvement is a major determinant of the prognosis of SLE. The histological classification of LN is a key factor in determining the renal survival of patients with LN. Prompt recognition and treatment of renal disease are important, as early response to therapy is correlated with better outcome and renal biopsy plays an important role in achieving this. OBJECTIVES: The objective of this study was to correlate the clinical and laboratory findings with histopathological classes of LN as per the 2003 International Society of Nephrology-Renal Pathology Society (ISN/RPS) classification system...
July 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28705011/the-experiences-and-beliefs-of-patients-with-complex-regional-pain-syndrome-an-exploratory-survey-study
#17
Adriaan Louw, Kory Zimney, Terry Cox, Christine O'Hotto, Craig A Wassinger
Objectives To determine the beliefs and describe the health care experiences of patients with complex regional pain syndrome. Methods A survey tool for patients with complex regional pain syndrome was designed for this study. The survey tool collected self-reported measures associated with pain, disability, health care experiences, education, beliefs, and treatments. Results Thirty-one patients attending physical therapy for complex regional pain syndrome (mean age 40.48; female n = 20) completed the survey...
January 1, 2017: Chronic Illness
https://www.readbyqxmd.com/read/28704423/application-of-near-infrared-hyperspectral-imaging-to-discriminate-different-geographical-origins-of-chinese-wolfberries
#18
Wenxin Yin, Chu Zhang, Hongyan Zhu, Yanru Zhao, Yong He
Near-infrared (874-1734 nm) hyperspectral imaging (NIR-HSI) technique combined with chemometric methods was used to trace origins of 1200 Chinese wolfberry samples, which from Ningxia, Inner Mongolia, Sinkiang and Qinghai in China. Two approaches, named pixel-wise and object-wise, were investigated to discriminative the origin of these Chinese wolfberries. The pixel-wise classification assigned a class to each pixel from individual Chinese wolfberries, and with this approach, the differences in the Chinese wolfberries from four origins were reflected intuitively...
2017: PloS One
https://www.readbyqxmd.com/read/28704368/mouse-models-of-17q21-31-microdeletion-and-microduplication-syndromes-highlight-the-importance-of-kansl1-for-cognition
#19
Thomas Arbogast, Giovanni Iacono, Claire Chevalier, Nurudeen O Afinowi, Xander Houbaert, Matthijs C van Eede, Christine Laliberte, Marie-Christine Birling, Katrin Linda, Hamid Meziane, Mohammed Selloum, Tania Sorg, Nael Nadif Kasri, David A Koolen, Henk G Stunnenberg, R Mark Henkelman, Maksym Kopanitsa, Yann Humeau, Bert B A De Vries, Yann Herault
Koolen-de Vries syndrome (KdVS) is a multi-system disorder characterized by intellectual disability, friendly behavior, and congenital malformations. The syndrome is caused either by microdeletions in the 17q21.31 chromosomal region or by variants in the KANSL1 gene. The reciprocal 17q21.31 microduplication syndrome is associated with psychomotor delay, and reduced social interaction. To investigate the pathophysiology of 17q21.31 microdeletion and microduplication syndromes, we generated three mouse models: 1) the deletion (Del/+); or 2) the reciprocal duplication (Dup/+) of the 17q21...
July 13, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28701997/early-intranasal-vasopressin-administration-impairs-partner-preference-in-adult-male-prairie-voles-microtus-ochrogaster
#20
Trenton C Simmons, Jessica F Balland, Janeet Dhauna, Sang Yun Yang, Jason L Traina, Jessica Vazquez, Karen L Bales
Research supports a modulatory role for arginine vasopressin (AVP) in the expression of socially motivated behaviors in mammals. The acute effects of AVP administration are demonstrably pro-social across species, providing the justification for an ever-increasing measure of clinical interest over the last decade. Combining these results with non-invasive intranasal delivery results in an attractive system for offering intranasal AVP (IN-AVP) as a therapeutic for the social impairments of children with autism spectrum disorder...
2017: Frontiers in Endocrinology
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