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https://www.readbyqxmd.com/read/28350654/a-prospective-randomized-trial-of-the-efficacy-of-fibrin-glue-triamcinolone-acetonide-and-quilting-sutures-in-seroma-prevention-after-latissimus-dorsi-breast-reconstruction
#1
Alexandra M Hart, Clarie Duggal, Ximena Pinell-White, Albert Losken
BACKGROUND: Donor-site seroma is the most common complication following latissimus dorsi flap breast reconstruction. Various agents and techniques have attempted to minimize seroma formation. The purpose of this study was to compare the efficacy of different products and quilting sutures at seroma prevention. METHODS: This is a single-center, double-blinded, randomized, controlled trial of a consecutive series of breast cancer patients (n = 96) undergoing latissimus dorsi flap reconstruction performed by a single surgeon...
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28350586/predictors-of-outcome-in-conservative-and-minimally-invasive-surgical-management-of-pain-originating-from-the-sacroiliac-joint-a-pooled-analysis
#2
Julius Dengler, Bradley Duhon, Peter Whang, Clay Frank, John Glaser, Bengt Sturesson, Steven Garfin, Daniel Cher, Aaron Rendahl, David Polly
STUDY DESIGN: A pooled patient-level analysis of two multicenter randomized controlled trials and one multicenter single-arm prospective trial. OBJECTIVE: To identify predictors of outcome of conservative and minimally invasive surgical management of pain originating from the sacroiliac joint (SIJ). SUMMARY OF BACKGROUND DATA: Three recently published prospective trials have shown that minimally invasive SIJ fusion (SIJF) using triangular titanium implants produces better outcomes than conservative management for patients with pain originating from the SIJ...
March 27, 2017: Spine
https://www.readbyqxmd.com/read/28350578/increasing-voluntary-medical-male-circumcision-uptake-among-adult-men-in-tanzania
#3
Mwita Wambura, Hally Mahler, Jonathan M Grund, Natasha Larke, Gerry Mshana, Evodius Kuringe, Marya Plotkin, Gissenge Lija, Maende Makokha, Fern Terris-Prestholt, Richard J Hayes, John Changalucha, Helen A Weiss
OBJECTIVE: We evaluated a demand-creation intervention to increase voluntary medical male circumcision (VMMC) uptake among men aged 20-34 years in Tanzania, to maximise short-term impact on HIV incidence. METHODS: A cluster randomized controlled trial stratified by region was conducted in 20 outreach sites in Njombe and Tabora regions. The sites were randomized 1 : 1 to receive either a demand-creation intervention package in addition to standard VMMC outreach, or standard VMMC outreach alone...
April 24, 2017: AIDS
https://www.readbyqxmd.com/read/28346864/application-of-the-l-dex-score-for-the-assessment-of-bilateral-leg-edema
#4
Kotaro Suehiro, Noriyasu Morikage, Takasuke Harada, Makoto Samura, Yuriko Takeuchi, Takahiro Mizoguchi, Kaori Nakamura, Kimikazu Hamano
BACKGROUND: We evaluated a modified L-Dex score by using the right arm as a reference (LDSrarm), to determine whether it could be used for the assessment of leg edema in place of the usual L-Dex score calculated by using the contralateral normal leg as a reference (LDScont). METHODS: Bioimpedance analysis was performed in the legs and right arms of 38 patients with unilateral leg edema and in 42 healthy volunteers by using a standard equipotential electrode arrangement...
March 27, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28346854/breast-cancer-related-lymphedema-differentiating-fat-from-fluid-using-magnetic-resonance-imaging-segmentation
#5
Yuka Sen, Yi Qian, Louise Koelmeyer, Robert Borotkanics, Robyn Ricketts, Helen Mackie, Thomas C Lam, Kevin Ho Shon, Hiroo Suami, John Boyages
BACKGROUND: Lymphedema is an iatrogenic complication after breast cancer treatment in which lymph fluid in the affected limb progresses to fat deposition and fibrosis that are amenable to liposuction treatment. Magnetic resonance imaging (MRI) for lymphedema can differentiate fat tissue from fluid, but estimating relative volumes remains problematic. METHODS AND RESULTS: Patients underwent routine bilateral arm MRI both before and after liposuction for advanced lymphedema...
March 27, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28346852/preoperative-lymphedema-related-risk-factors-in-early-stage-breast-cancer
#6
Zeynep Erdogan Iyigun, Tomris Duymaz, Ahmet Serkan Ilgun, Gul Alco, Cetin Ordu, Dauren Sarsenov, Ayse Esra Aydin, Filiz Elbuken Celebi, Filiz Izci, Yeşim Eralp, Vahit Ozmen
BACKGROUND: Prolongation of survival in patients with breast cancer due to early diagnosis and modern methods of treatment has turned the attention on lymphedema, which is the most important morbidity secondary to the treatment of the disease. Determination of lymphedema and related risk factors in patients before a surgical intervention may provide protection for patients and early treatment. The aim of this study was to determine the presence of lymphedema before surgery by bioimpedance analysis in patients with breast cancer and to establish risk factors associated with lymphedema...
March 27, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28346823/design-and-monitoring-of-multi-arm-multi-stage-clinical-trials
#7
Pranab Ghosh, Lingyun Liu, P Senchaudhuri, Ping Gao, Cyrus Mehta
Two-arm group sequential designs have been widely used for over 40 years, especially for studies with mortality endpoints. The natural generalization of such designs to trials with multiple treatment arms and a common control (MAMS designs) has, however, been implemented rarely. While the statistical methodology for this extension is clear, the main limitation has been an efficient way to perform the computations. Past efforts were hampered by algorithms that were computationally explosive. With the increasing interest in adaptive designs, platform designs, and other innovative designs that involve multiple comparisons over multiple stages, the importance of MAMS designs is growing rapidly...
March 27, 2017: Biometrics
https://www.readbyqxmd.com/read/28346492/dual-energy-x-ray-absorptiometry-body-composition-reference-values-of-limbs-and-trunk-from-nhanes-1999-2004-with-additional-visualization-methods
#8
Benjamin J Hinton, Bo Fan, Bennett K Ng, John A Shepherd
Body Mass Index has traditionally been used as a measure of health, but Fat Mass Index (FMI) and Lean Mass Index (LMI) have been shown to be more predictive of mortality and health risk. Total body FMI and LMI reference curves have particularly been useful in quantifying sarcopenia and sarcopenic obesity. Research has shown regional composition has significant associations to health outcomes. We derived FMI and LMI reference curves of the regions of the body (leg, arm, and trunk) for 15,908 individuals in the 1999-2004 National Health and Nutrition Examination Survey data for each sex and ethnicity using the Lambda-Mu-Sigma (LMS) method and developed software to visualize this regional composition...
2017: PloS One
https://www.readbyqxmd.com/read/28346064/modeling-and-simulation-of-two-wheelchair-accessories-for-pushing-doors
#9
Soran Jalal Abdullah, Javeed Shaikh Mohammed
Independent mobility is vital to individuals of all ages, and wheelchairs have proven to be great personal mobility devices. The tasks of opening and navigating through a door are trivial for healthy people, while the same tasks could be difficult for some wheelchair users. A wide range of intelligent wheelchair controllers and systems, robotic arms, or manipulator attachments integrated with wheelchairs have been developed for various applications, including manipulating door knobs. Unfortunately, the intelligent wheelchairs and robotic attachments are not widely available as commercial products...
March 27, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/28345961/the-short-term-efficacy-of-an-unguided-internet-based-cognitive-behavioral-therapy-for-insomnia-a-randomized-controlled-trial-with-a-six-month-nonrandomized-follow-up
#10
Susanne Hagatun, Øystein Vedaa, Tine Nordgreen, Otto R F Smith, Ståle Pallesen, Odd E Havik, Bjørn Bjorvatn, Frances P Thorndike, Lee M Ritterband, Børge Sivertsen
OBJECTIVE: Insomnia is a major health problem, and the need for effective and accessible treatment is urgent. The aim of the current study was to evaluate the short-term efficacy of an unguided Internet-based cognitive-behavioral treatment program for insomnia (CBTi), called SHUTi (Sleep Healthy Using the Internet). METHODS: This study used a parallel arm randomized controlled trial in Norway. Participants were randomly allocated to the SHUTi condition or a Web-based patient education condition...
March 27, 2017: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28345944/enhanced-integration-of-multisensory-body-information-by-proximity-to-habitual-action-space
#11
Harriet Dempsey-Jones, Ada Kritikos
Previous research suggests integration of visual and somatosensory inputs is enhanced within reaching (peripersonal) space. In such experiments, somatosensory inputs are presented on the body while visual inputs are moved relatively closer to, or further from the body. It is unclear, therefore, whether enhanced integration in "peripersonal space" is truly due to proximity of visual inputs to the body space, or, simply the distance between the inputs (which also affects integration). Using a modified induction of the rubber hand illusion, here we measured proprioceptive drift as an index of visuosomatosensory integration when distance between the two inputs was constrained, and absolute distance from the body was varied...
April 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28345891/tailored-chemical-properties-of-4-arm-star-shaped-poly-d-l-lactide-as-cell-adhesive-three-dimensional-scaffolds
#12
Chelladurai Karthikeyan Balavigneswaran, Sanjeev Kumar Mahto, Subia Bano, Arumugam Prabhakar, Kheyanath Mitra, Vivek Rao, Munia Ganguli, Biswajit Ray, Pralay Maiti, Nira Misra
Biodegradable poly(lactic acid) (PLA) is widely used to fabricate 3D scaffolds for tissue regeneration. However, PLA lacks cell adhering functional moieties, which limit its successful application in tissue engineering. Herein, we have tailored the cell adhesive properties of star shaped poly(D,L-Lactide) (ss-PDLLA) by grafting gelatin to their 4 arms. Grafting of gelatin on PDLLA backbone was confirmed by 1H NMR and FTIR. The synthesized star shaped poly(D,L-Lactide)-b-Gelatin (ss-pLG) exhibited enhanced wettability and protein adsorption...
March 27, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28345825/comparison-of-hypersensitivity-reactions-to-carboplatin-retreatment-in-gynecologic-cancer-patients-between-one-and-two-hour-infusions-a-randomized-trial-study
#13
Weerawich Pornwattanakrilert, Prapaporn Suprasert
Objective: To compare the incidence rate of carboplatin hypersensitivity reactions (HSRs) in gynecologic cancer patients receiving one-hour or two-hour carboplatin retreatment infusions. Setting: A Prospective Randomized Controlled Trial. Methods: Recurrent gynecologic cancer patients 25 to 80-years of age who were scheduled to receive carboplatin retreatment after previously receiving at least six cycles of carboplatin without a history of platinum allergy were invited to enroll. They were randomized to receive either a one-hour or two-hour carboplatin infusion in each cycle...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28345754/second-to-fourth-digit-ratio-2d-4d-is-unrelated-to-measures-of-somatic-reproductive-effort-among-young-men-from-cebu-the-philippines
#14
Alexander V Georgiev, Calen P Ryan, Lee T Gettler, Thomas W McDade, Christopher W Kuzawa
OBJECTIVES: A low second-to-fourth (2D:4D) digit ratio, a retrospective marker of high prenatal androgens, predicts increased investment in costly sexually dimorphic traits in men in some studies, although results are mixed. Here we test the hypothesis that the association of low 2D:4D ratios with increased muscularity and decreased adiposity depends on current testosterone (T) levels, such that digit ratio will be a particularly strong predictor of outcomes among men exhibiting a mating-effort-oriented endocrinological profile (high T)...
March 27, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28345733/-hand-fine-motor-skills-and-use-of-both-hand-and-arm-in-subjects-after-a-stroke-a-systematic-review
#15
M Ostolaza, J Abudarham, S Dilascio, E Drault-Boedo, S Gallo, A Garcete, M Kramer, M Maiaru, A Mendelevich, M Modica, F Peralta, C Sanchez-Correa
INTRODUCTION: In clinical practice it is important to be able to assess the function of the upper limb of the patient who has suffered a stroke. There is currently no systemic review that could identify assessment tools for the 'fine use of the hand' and 'use of both hand and arm'. AIMS: Primary, to identify observational tools which can assess the fine use of the hand and the use of both hand and arm in patients with stroke sequels. Secondary, to analyze the bias risk in the included articles, describing and categorizing the clinical utility, validity and reliability...
April 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28345728/embedding-1d-or-2d-cobalt-carboxylate-substrates-in-3d-coordination-polymers-exhibiting-slow-magnetic-relaxation-behaviors-crystal-structures-high-field-epr-and-magnetic-studies
#16
Nannan Mao, Biquan Zhang, Fan Yu, Xi Chen, Gui-Lin Zhuang, Zhenxing Wang, Zhongwen Ouyang, Tianle Zhang, Bao Li
By utilizing well-designed bifunctional ligands derived from 1H-imidazole-4,5-dicarboxylic acid, magnetic coordination polymers (CPs) that exhibit slow magnetic relaxation at the low temperature regions were constructed and further structurally characterized. In 1, 1D cobalt-carboxyl chains were stabilized in the final structure. In contrast, by adjusting the length of the substituted arms on imidazole-4,5-dicarboxylic acid, a novel 3D CP, 2 containing 2D 6(3) cobalt-carboxyl layer was obtained. A combination of Quantum Monte Carlo (QMC) simulations and the first-principles Density functional theory (DFT) calculations showed that compound 2 features weak ferro- and antiferro-magnetic coupling mechanisms with two different super-exchange paths of -/+/- for syn-anti carboxylate bridges and -/-/- for syn-syn carboxylate bridges...
March 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28345504/the-association-between-dietary-inflammatory-index-scores-and-the-prevalence-of-colorectal-adenoma
#17
Alyson Haslam, Sara Wagner Robb, James R Hébert, Hanwen Huang, Michael D Wirth, Nitin Shivappa, Mark H Ebell
OBJECTIVE: The Dietary Inflammatory Index (DII)TM, which was developed to characterize the inflammatory potential of a person's diet, has been shown to be associated with inflammatory conditions such as cancer. The present study aimed to investigate the association between DII scores and colorectal adenoma (CRA), a pre-cancerous condition. DESIGN: Responses to baseline dietary questionnaires were used calculate DII scores. In a cross-sectional study design, the association between DII scores and CRA prevalence was determined in men and women separately using logistic regression models...
March 27, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28345432/utero-placental-perfusion-doppler-indices-in-growth-restricted-fetuses-effect-of-sildenafil-citrate
#18
Mohamed Adel El-Sayed, Said Abdel-Aty Saleh, Mohammad Ahmed Maher, Asmaa Mohamed Khidre
OBJECTIVE: To assess efficacy and tolerability of sildenafil citrate on utero-placental blood flow and fetal growth in pregnancies complicated by fetal growth restriction (FGR). METHODS: From March 2015, a randomized controlled trial of 54 patients at 24 weeks or more complicated by FGR and abnormal Doppler indices were randomly allocated 1:1 into an intervention arm (receive sildenafil citrate, 50 mg) or a control arm (receive placebo). The primary outcomes were changes occurred in the Doppler parameters 2 h following drug administration...
March 27, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28345387/multimodal-treatment-in-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-a-6-month-follow-up
#19
Nezla S Duric, Jørg Assmus, Doris Gundersen, Alisa Duric Golos, Irene B Elgen
BACKGROUND: Different treatment approaches aimed at reducing attention-deficit/hyperactivity disorder (ADHD) core symptoms are available. However, factors such as intolerance, side-effects, lack of efficacy, high new technology costs, and placebo effect have spurred on an increasing interest in alternative or complementary treatment. AIM: The aim of this study is to explore efficacy of multimodal treatment consisting of standard stimulant medication (methylphenidate) and neurofeedback (NF) in combination, and to compare it with the single treatment in 6-month follow-up in ADHD children and adolescents...
March 27, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28345259/the-role-of-complement-inhibitors-beyond-controlling-inflammation
#20
REVIEW
A M Blom
The complement system is an arm of innate immunity that aids in the removal of pathogens and dying cells. Due to its harmful, pro-inflammatory potential, complement is controlled by several soluble and membrane-bound inhibitors. This family of complement regulators has been recently extended by the discovery of several new members, and it is becoming apparent that these proteins harbour additional functions. In this review, the current state of knowledge of the physiological functions of four complement regulators will be described: cartilage oligomeric matrix protein (COMP), CUB and sushi multiple domains 1 (CSMD1), sushi domain-containing protein 4 (SUSD4) and CD59...
March 26, 2017: Journal of Internal Medicine
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