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https://www.readbyqxmd.com/read/29471558/indication-technique-and-long-term-results-after-shoulder-arthrodesis-performed-with-plate-fixation
#1
Ulrich Irlenbusch, Olaf Rott, Lars Irlenbusch
AIM: Arthrodesis of the shoulder joint is a radical event, so it is difficult to explain its significance to patients. It has been the last resort in hopeless cases. Knowledge of long-term results and evaluation of advantages and disadvantages seems to be helpful in this regard. METHODS: Eleven patients with mean age of 45 (31 - 58) years were operated between 2000 and 2013. All patients could be included in the investigation (FU mean 8.5 [3 - 16] years; 8 male and 3 female; right 9, left 2)...
February 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29471466/changes-in-metabolites-present-in-lung-lining-fluid-following-exposure-of-humans-to-ozone
#2
WanYun Cheng, Kelly E Duncan, Andrew J Ghio, Cavin Ward-Caviness, Edward D Karoly, David Diaz-Sanchez, Rory B Conolly, Robert B Devlin
Controlled human exposure to the oxidant air pollutant ozone causes decrements in lung function and increased inflammation as evidenced by neutrophil influx into the lung and increased levels of proinflammatory cytokines in the airways. Here we describe a targeted metabolomics evaluation of human bronchioalveolar lavage fluid (BALF) following controlled in vivo exposure to ozone to gain greater insight into its pulmonary effects. In a two-arm cross-over study, each healthy adult human volunteer was randomly exposed to filtered air (FA) and to 0...
February 19, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29471460/coaching-primary-care-clinics-for-hpv-vaccination-quality-improvement-comparing-in-person-and-webinar-implementation
#3
William A Calo, Melissa B Gilkey, Jennifer Leeman, Jennifer Heisler-MacKinnon, Chrystal Averette, Stephanie Sanchez, Melanie L Kornides, Noel T Brewer
State health departments commonly use quality improvement coaching as an implementation strategy for improving low human papillomavirus (HPV) vaccination coverage, but such coaching can be resource intensive. To explore opportunities for improving efficiency, we compared in-person and webinar delivery of coaching sessions on implementation outcomes, including reach, acceptability, and delivery cost. In 2015, we randomly assigned 148 high-volume primary care clinics in Illinois, Michigan, and Washington State to receive either in-person or webinar coaching...
February 20, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29471212/nodular-fasciitis-mimicking-a-soft-tissue-sarcoma-a-case-report
#4
Vatsal Khanna, Manikandan Rajan, Trishya Reddy, Naveen Alexander, Parmasivam Surendran
INTRODUCTION: Nodular Fasciitis, also known as infiltrative or pseudosarcomatous fasciitis, is a benign soft tissue tumour of fibroblastic/myofibroblastic differentiation, that was first described in 1955 by Konwaler et al. PRESENTATION OF CASE: This is a case report of a 27-year old male with complaints of a swelling in the right axilla for 2 and ½ years measuring 12 cm × 10 cm. Chest X-Ray was normal. Magnetic Resonance Imaging of the right arm and chest showed an irregular mass in the axilla in the muscular-subcutaneous plane measuring 10...
February 15, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29471152/carpal-tunnel-release-with-a-new-mini-incision-approach-versus-a-conventional-approach-a-retrospective-cohort-study
#5
Jiangbo Bai, Lingde Kong, Hongfang Zhao, Kunlun Yu, Bing Zhang, Jichun Zhang, Dehu Tian
PURPOSE: We have make use of a new method to perform carpal tunnel release (CTR) through a 1.5-2.0 cm long incision The aim of this study is to introduce this method and to compare the effectiveness and safety of this approach to the conventional one. METHODS: We included consecutive patients diagnosed with primary carpal tunnel syndrome (CTS) who had CTR from January 2015 to September 2016. A total of 85 patients were included in our study. Among them, 42 patients with mini-incision approach were enrolled in group A, and the other 43 patients with conventional approach were enrolled in group B...
February 19, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29471077/fabrication-of-antibody-loaded-microgels-using-microfluidics-and-thiol-ene-photoclick-chemistry
#6
Manuel Gregoritza, Kathrin Abstiens, Moritz Graf, Achim M Goepferich
Reducing burst effects, providing controlled release, and safeguarding biologics against degradation are a few of several highly attractive applications for microgels in the field of controlled release. However, the incorporation of proteins into microgels without impairing stability is highly challenging. In this proof of concept study, the combination of microfluidics and thiol-ene photoclick chemistry was evaluated for the fabrication of antibody-loaded microgels with narrow size distribution. Norbornene-modified eight-armed poly(ethylene glycol) with an average molecular mass of 10,000 Da, 20,000 Da, or 40,000 Da were prepared as macromonomers for microgel formation...
February 19, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29470934/bivalent-oral-cholera-vaccine-in-participants-aged-1-year-and-older-in-the-dominican-republic-a-phase-iii-single-arm-safety-and-immunogenicity-trial
#7
Lina Cordero De Los Santos, Jesús Feris-Iglesias, Naveena Aloysia D'Cor, Venkata Jayanth Midde, Badri Narayan Patnaik, Yaël Thollot, Anvar Rasuli, Eric Desauziers
The Dominican Republic, historically non-endemic for cholera, is experiencing an ongoing cholera epidemic. We assessed the safety and immunogenicity of two doses of the killed bivalent (O1 and O139) whole-cell oral cholera vaccine (OCV) on day (D)0 and D14 in healthy participants aged ≥1 year. Immediate unsolicited systemic adverse events (AEs) were monitored up to 30 minutes and solicited systemic reactions, up to 7 days after each vaccination. Unsolicited AEs were recorded up to D14 (post-dose 1) and 30 days post-dose 2...
February 22, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29470913/interlocking-mechanism-between-molecular-gears-attached-to-surfaces
#8
Rundong Zhao, Yan-Ling Zhao, Fei Qi, Klaus E Hermann, Rui-Qin Zhang, Michel A Van Hove
While molecular machines play an increasingly significant role in nanoscience research and applications, there remains a shortage of investigations and understanding of the molecular gear (cogwheel), which is an indispensable and fundamental component to drive a larger correlated molecular machine system. Employing ab initio calculations, we investigate model systems consisting of molecules adsorbed on metal or graphene surfaces, ranging from very simple triple-arm gears such as PF3 and NH3 to larger multi-arm gears based on carbon rings...
February 22, 2018: ACS Nano
https://www.readbyqxmd.com/read/29470854/the-cost-effectiveness-of-screening-in-the-community-to-reduce-osteoporotic-fractures-in-older-women-in-the-uk-economic-evaluation-of-the-scoop-study
#9
David A Turner, Rebekah Fong Soe Khioe, Lee Shepstone, Elizabeth Lenaghan, Cyrus Cooper, Neil Gittoes, Nicholas C Harvey, Richard Holland, Amanda Howe, Eugene McCloskey, Terence W O'Neill, David Torgerson, Richard Fordham
The SCOOP study was a two-arm randomized controlled trial conducted in the UK in 12,483 eligible women aged 70 to 85 years. It compared a screening program using the FRAX® risk assessment tool in addition to bone mineral density (BMD) measures versus usual management. The SCOOP study found a reduction in the incidence of hip fractures in the screening arm, but there was no evidence of a reduction in the incidence of all osteoporosis-related fractures. To make decisions about whether to implement any screening program, we should also consider whether the program is likely to be a good use of health care resources, ie, is it cost-effective? The cost per gained quality adjusted life year of screening for fracture risk has not previously been demonstrated in an economic evaluation alongside a clinical trial...
February 22, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29470807/longitudinal-effects-of-adjuvant-endocrine-therapy-on-the-quality-of-life-of-post-menopausal-women-with-non-metastatic-er-breast-cancer-a-systematic-review
#10
REVIEW
Hong Xiao, Xinyi Jiang, Cheng Chen, Alberto J Montero, Vakaramoko Diaby
BACKGROUND: Anti-estrogen (ER) endocrine therapy is an effective treatment strategy in reducing breast cancer mortality. This therapy has a better therapeutic index than chemotherapy but can still affect patients' quality of life (QOL) over time. OBJECTIVE: The objectives of this systematic review were to (1) describe QOL instruments used in ER-positive (ER+) non-metastatic breast cancer trials and (2) document the longitudinal effects of adjuvant endocrine therapy on the QOL of post-menopausal women with ER+ non-metastatic breast cancer...
February 22, 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29470804/effects-of-physical-exercise-on-breast-cancer-related-secondary-lymphedema-a-systematic-review
#11
REVIEW
F T Baumann, A Reike, V Reimer, M Schumann, M Hallek, D R Taaffe, R U Newton, D A Galvao
PURPOSE: The aim of this systematic review is to assess the effect of different types of exercise on breast cancer-related lymphedema (BCRL) in order to elucidate the role of exercise in this patient group. METHODS: A systematic data search was performed using PubMed (December 2016). The review is focused on the rehabilitative aspect of BCRL and undertaken according to the PRISMA statement with Levels of Evidence (LoE) assessed. RESULTS: 11 randomized controlled trials (9 with LoE 1a and 2 with LoE 1b) that included 458 women with breast cancer in aftercare were included...
February 22, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29470681/a-large-scale-multiomics-analysis-of-wheat-stem-solidness-and-the-wheat-stem-sawfly-feeding-response-and-syntenic-associations-in-barley-brachypodium-and-rice
#12
Sezgi Biyiklioglu, Burcu Alptekin, B Ani Akpinar, Andrea C Varella, Megan L Hofland, David K Weaver, Brian Bothner, Hikmet Budak
The wheat stem sawfly (WSS), Cephus cinctus Norton (Hymenoptera: Cephidae), is an important pest of wheat and other cereals, threatening the quality and quantity of grain production. WSS larvae feed and develop inside the stem where they are protected from the external environment; therefore, pest management strategies primarily rely on host plant resistance. A major locus on the long arm of wheat chromosome 3B underlies most of the variation in stem solidness; however, the impact of stem solidness on WSS feeding has not been completely characterized...
February 22, 2018: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/29470615/pre-dosing-with-lilotomab-prior-to-therapy-with-177-lu-lilotomab-satetraxetan-significantly-increases-the-ratio-of-tumor-to-red-marrow-absorbed-dose-in-non-hodgkin-lymphoma-patients
#13
Caroline Stokke, Johan Blakkisrud, Ayca Løndalen, Jostein Dahle, Anne C T Martinsen, Harald Holte, Arne Kolstad
PURPOSE: 177 Lu-lilotomab satetraxetan is a novel anti-CD37 antibody radionuclide conjugate for the treatment of non-Hodgkin lymphoma (NHL). Four arms with different combinations of pre-dosing and pre-treatment have been investigated in a first-in-human phase 1/2a study for relapsed CD37+ indolent NHL. The aim of this work was to determine the tumor and normal tissue absorbed doses for all four arms, and investigate possible variations in the ratios of tumor to organs-at-risk absorbed doses...
February 22, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29470579/defining-the-most-appropriate-primary-end-point-in-phase-2-trials-of-immune-checkpoint-inhibitors-for-advanced-solid-cancers-a-systematic-review-and-meta-analysis
#14
Georgia Ritchie, Harry Gasper, Johnathan Man, Sally Lord, Ian Marschner, Michael Friedlander, Chee Khoon Lee
Importance: Checkpoint inhibitors have a unique mechanism of action that differs from chemotherapy or targeted therapies. The validity of objective response rate (ORR) as a surrogate for progression-free survival (PFS) and overall survival (OS) in checkpoint-inhibitor trials is uncertain. Objective: To determine the types of primary end points used in phase 2 checkpoint-inhibitor trials, and to assess the strength of associations for ORR with PFS and OS. Data Sources: Trials listed in electronic databases from 2000 to 2017 (PREMEDLINE, MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials)...
February 22, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29470434/pharmacokinetics-and-scintigraphic-imaging-of-the-hypoxia-imaging-agent-123-i-iaza-in-healthy-adults-following-exercise-based-cardiac-stress-%C3%A2
#15
Daria Stypinski, Stephen A McQuarrie, Alexander J B McEwan, Leonard I Wiebe
The objective of this work is to evaluate the potential effect of cardiac stress exercise on the accumulation of [123 I]IAZA, a radiopharmaceutical used to image focal tissue hypoxia, in otherwise normal myocardium in healthy volunteers, and to determine the impact of exercise on [123 I]IAZA pharmacokinetics. The underlying goal is to establish a rational basis and a baseline for studies of focal myocardial hypoxia in cardiac patients using [123 I]IAZA. Three healthy male volunteers ran the 'Bruce' treadmill protocol, a clinically-accepted protocol designed to expose myocardial ischemia in patients...
February 22, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29470425/major-histocompatibility-complex-and-hematopoietic-stem-cell-transplantation-beyond-the-classical-hla-polymorphism
#16
REVIEW
Alice Bertaina, Marco Andreani
Allogeneic hematopoietic stem cell transplantation (HSCT) represents a curative treatment for many patients with hematological malignant or non-malignant disorders. Evaluation of potential donors for HSCT includes a rigorous assessment of the human leukocyte antigens (HLA) match status of family members, and the identification of suitable unrelated donors. Genes encoding transplantation antigens are placed both within and outside the major histocompatibility complex (MHC). The human MHC is located on the short arm of chromosome 6 and contains a series of genes encoding two distinct types of highly polymorphic cell surface glycoproteins...
February 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29470173/preemptive-nudt15-genotyping-redefining-the-management-of-patients-with-thiopurine-induced-toxicity
#17
Swarup A V Shah, Minal U Paradkar, Devendra C Desai, Tester F Ashavaid
BACKGROUND: Thiopurine methyltransferase (TPMT) gene variants have achieved limited success in predicting the outcome of thiopurine therapy, which shows wide inter-individual variations. The literature indicates a strong association between the NUDT15 gene variant and thiopurine-induced toxicity in Asian patients. The present study intends to explore the role of the NUDT15 variant (C415T) in Indian patients on thiopurine therapy. METHODS: NUDT15 and TPMT genotyping were performed using amplification-refractory mutation system-polymerase chain reaction (ARMS-PCR) and the restriction fragment length polymorphism (RFLP) technique...
February 22, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/29469944/multicentre-randomized-clinical-trial-of-the-effect-of-chewing-gum-after-abdominal-surgery
#18
E M de Leede, N J van Leersum, H M Kroon, V van Weel, J R M van der Sijp, B A Bonsing
BACKGROUND: Postoperative ileus is a common complication of abdominal surgery, leading to patient discomfort, morbidity and prolonged postoperative length of hospital stay (LOS). Previous studies suggested that chewing gum stimulates bowel function after abdominal surgery, but were underpowered to evaluate its effect on LOS and did not include enhanced recovery after surgery (ERAS)-based perioperative care. This study evaluated whether chewing gum after elective abdominal surgery reduces LOS and time to bowel recovery in the setting of ERAS-based perioperative care...
February 22, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29469927/cost-effectiveness-analysis-of-stent-type-in-endoscopic-treatment-of-gastric-leak-after-laparoscopic-sleeve-gastrectomy
#19
C Cosse, L Rebibo, F Brazier, S Hakim, R Delcenserie, J M Regimbeau
BACKGROUND: Gastric leak is the most feared surgical postoperative complication after sleeve gastrectomy. An endoscopic procedure is usually required to treat the leak. No data are available on the cost-effectiveness of different stent types in this procedure. METHODS: Between April 2005 and July 2016, patients with a confirmed gastric leak undergoing endoscopic treatment using a covered stent (CS) or double-pigtail stent (DPS) were included. The primary objective of the study was to assess overall costs of the stent types after primary sleeve gastrectomy...
February 22, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29469810/design-and-analysis-of-coiled-fiber-reinforced-soft-pneumatic-actuator
#20
Gaurav Singh, Chenzhang Xiao, Elizabeth T Hsiao-Wecksler, Girish Krishnan
Fiber Reinforced Elastomeric Enclosures (FREEs) are soft pneumatic actuators that can contract and generate forces upon pressurization. Typical engineering applications utilize FREEs in its straight cylindrical configuration, and derive actuation displacement and forces from its ends. However, there are several instances in nature, such as an elephant trunk, snake, and grapevine tendril, where a spiral configuration of muscle systems is used for gripping, thereby establishing a mechanical connection with uniform force distribution...
February 22, 2018: Bioinspiration & Biomimetics
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