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Amir Almatlouh, Daniella Bach-Holm, Line Kessel
Surgical outcome after trabeculectomy depends on maintaining a functional bleb which requires a delicate balance between incomplete wound healing to prevent fibrosis and enough wound healing to prevent hyperfiltration. Thus, controlling the inflammatory response is essential. We conducted a systematic review and meta-analysis to compare the effectiveness of different formulations of steroids (topical, systemic and depot) and nonsteroidal anti-inflammatory drugs (NSAIDs) in achieving long-term pressure control with fewer antiglaucomatous medications, preserving visual acuity and visual fields while considering surgical and postoperative complications...
September 21, 2018: Acta Ophthalmologica
Jiajia Wang, Zongliang Lu, Changpeng Wu, Yanwu Li, Ya Kong, Rui Zhou, Kun Shi, Jing Guo, Na Li, Jie Liu, Wei Song, He Wang, Mingxing Zhu, Hongxia Xu
BACKGROUND: Voltage-gated sodium channels (VGSCs) are involved in several cellular processes related to cancer cell growth and metastasis, including adhesion, proliferation, apoptosis, migration, and invasion. We here in investigated the effects of S0154 and S0161, two novel synthetic sodium channel blockers (SCBs), on human prostate cancer cells (PC3, DU145, and LnCaP) and a prostate cancer xenograft model. METHODS: The MTT assay was used to assess the anticancer effects of SCBs in PC3, DU145, and LnCaP cells...
September 21, 2018: Prostate
Domenica Roberto, Laurence H Klotz, Vasundara Venkateswaran
BACKGROUND: Cannabinoids have demonstrated anticarcinogenic properties in a variety of malignancies, including in prostate cancer. In the present study, we explored the anti-cancer effects of the synthetic cannabinoid WIN 55,212-2 (WIN) in prostate cancer. METHODS: Established prostate cancer cells (PC3, DU145, LNCaP) were treated with varying concentrations of WIN. Cell proliferation was determined by the MTS assay. The anti-migration and anti-invasive potential of WIN was examined by the wound healing assay and the matrigel invasion assay...
September 21, 2018: Prostate
Witold W Kilarski, Esra Güç, Melody A Swartz
Postdevelopmental lymphangiogenesis occurs in chronic inflammation and wound healing, and here we describe a window preparation in the mouse ear in which lymphangiogenesis can be observed and manipulated. This model has many advantages, including access for intravital immunostaining and imaging to assess morphological features and regeneration kinetics, as well as functional assays such as lymphatic clearance. We describe five procedures: (1) the creation of a collagen-fibrin-filled window in the mouse ear as a model for regenerative lymphangiogenesis, (2) intravital immunostaining for live analysis of morphology and structure, (3) lymphatic clearance assay for functional quantification, (4) whole-mount imaging with tissue clearing for confocal imaging, and (5) postmortem lymphangiography...
2018: Methods in Molecular Biology
Gregory J Moran, Carisa De Anda, Anita F Das, Sinikka Green, Purvi Mehra, Philippe Prokocimer
INTRODUCTION: Injection drug users (IDUs) often develop acute bacterial skin and skin structure infections (ABSSSI) and use emergency departments as their primary source for medical care. METHODS: A post hoc subgroup analysis of two randomized trials examined the efficacy and safety of tedizolid in the treatment of ABSSSI in IDUs. IDUs (n = 389) were identified from two pooled phase 3 trials (NCT01170221, NCT01421511) in patients with ABSSSI (n = 1333). Patients were randomly assigned to tedizolid phosphate (200 mg once daily, 6 days) or linezolid (600 mg twice daily, 10 days)...
September 21, 2018: Infectious Diseases and Therapy
Zahra Nozhat, Samira Mohammadi-Yeganeh, Feridoun Azizi, Maryam Zarkesh, Mehdi Hedayati
BACKGROUND: The PI3K/AKT/FOXO signaling pathway plays an important role in the survival, proliferation and apoptosis of tumor cells. The aim of the present study was to explore whether metformin could affect insulin-promoting cell growth by regulation of this pathway. MATERIAL AND METHODS: Anaplastic thyroid cancer cells were treated with 0-60 mM metformin for 24, 48 and 72 h. Cell viability, morphology, apoptosis and migration were investigated by MTT assay, microscopy observation, AnexinV-PI and the wound healing assay, respectively...
September 21, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Marc Schnetzke, Thomas Wittmann, Patric Raiss, Gilles Walch
INTRODUCTION: The aim of the study was to evaluate the short-term clinical results of anatomic total shoulder arthroplasty with a short-stem prosthesis in primary osteoarthritis. MATERIALS AND METHODS: 65 shoulders with a mean age of 70 years (range 47-85 years) were available for minimum follow-up of 24 months. Clinical outcome was determined by range of motion, Constant score (CS) age and sex-adjusted Constant score (CS%), and subjective shoulder value (SSV)...
September 21, 2018: Archives of Orthopaedic and Trauma Surgery
N Kirsten, K Herberger, M Augustin, W Tigges, C Behrendt, F Heidemann, E S Debus, H Diener
According to the Research Group for Primary Medical Care (PMV), approximately 890,000 people in Germany were suffering from a chronic wound in 2012. This corresponds to a prevalence of 1.1%. Ulcus cruris, diabetic ulcers and decubital ulcers are among the most frequent causes of chronic wounds (57-80%). The guarantee for successful wound care is based on a good understanding of the physiology of the wound healing process. A disorder of the phase-like course can lead to complications, delays or suspension of wound healing...
September 21, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Theresa Ramalho, Luciano Filgueiras, Ildefonso Alves Silva-Jr, Ana Flavia Marçal Pessoa, Sonia Jancar
Type 1 diabetes is associated with systemic low grade inflammation (LGI). We have previously shown that LGI in diabetic mice depends on systemic circulation of leukotriene (LTB4 ) which potentiates the toll-like/IL1β receptors response in macrophages. Impaired wound healing is an important co-morbidity in diabetes, and macrophages play a key role in this process. Here, we investigated the role of leukotrienes on monocytes and macrophages phenotype and in the impaired wound healing in diabetic mice. Type 1 diabetes was induced with streptozotocin in 129SvE wild-type (WT) and leukotrienes-deficient 5LO-/- (5-lipoxygenase knockout) mice...
September 21, 2018: Scientific Reports
Philipp J Jost, Ulrike Höckendorf
The hematopoietic system represents an organ system with an exceptional capacity for the production of mature blood cells from a small and mostly quiescent pool of hematopoietic stem cells (HSCs). This extraordinary capacity includes self-renewal but also the propensity to rapidly respond to extrinsic needs, such as acute infections, severe inflammation, and wound healing. In recent years, it became clear that inflammatory signals such as cytokines, chemokine and danger signals from pathogens (PAMPs) or dying cells (DAMPs) impact on HSCs, shaping their proliferation status, lineage bias, and repopulating ability and subsequently increasing the output of mature effector cells...
September 21, 2018: Cell Death and Differentiation
Bethany Brunton, Lukkana Suksanpaisan, Hongtao Li, Qian Liu, Yinxian Yu, Alyssa Vrieze, Lianwen Zhang, Nathan Jenks, Huailei Jiang, Timothy R DeGrado, Chunfeng Zhao, Stephen J Russell, Kah-Whye Peng
Fibrogenesis is the underlying mechanism of wound healing and repair. Animal models that enable longitudinal monitoring of fibrogenesis are needed to improve traditional tissue analysis post-mortem. Here, we generated transgenic reporter rats expressing the sodium iodide symporter (NIS) driven by the rat collagen type-1 alpha-1 (Col1α1) promoter and demonstrated that fibrogenesis can be visualized over time using SPECT or PET imaging following activation of NIS expression by rotator cuff (RC) injury. Radiotracer uptake was first detected in and around the injury site day 3 following surgery, increasing through day 7-14, and declining by day 21, revealing for the first time, the kinetics of Col1α1 promoter activity in situ...
September 21, 2018: Scientific Reports
Sharman P Tan Tanny, Minjung Yoo, John M Hutson, Jacob C Langer, Sebastian K King
BACKGROUND: Surgical management of adult ulcerative colitis (UC) is well-studied, but not readily applicable to children. Restorative proctocolectomy with ileal pouch-anal anastomosis (RPC-IPAA), performed as one-, two-, or three-stage procedure, is preferred in pediatric patients with adequate anal sphincter function. PURPOSE: METHODS: Systematic review of Cochrane Register of Controlled Trials, PubMed, and EMBASE databases was conducted (January 1987-December 2016), in accordance with PRISMA...
September 7, 2018: Journal of Pediatric Surgery
Oyebola O Oyesola, Simon P Früh, Lauren M Webb, Elia D Tait Wojno
Parasitic helminth infection elicits a type 2 cytokine-mediated inflammatory response. During type 2 inflammation, damaged or stimulated epithelial cells exposed to helminths and their products produce alarmins and cytokines including IL-25, IL-33, and thymic stromal lymphopoietin. These factors promote innate immune cell activation that supports the polarization of CD4+ T helper type 2 (Th2) cells. Activated innate and Th2 cells produce the cytokines IL-4, -5, -9, and -13 that perpetuate immune activation and act back on the epithelium to cause goblet cell hyperplasia and increased epithelial cell turnover...
September 18, 2018: Cytokine
Siliang Li, Yang Gao, Haicheng Jiang, Lijie Duan, Guanghui Gao
Hydrophobic association hydrogels have been extensively studied during the past decades. However, the fracture stress of hydrophobic association hydrogels obtained with anionic surfactants (such as sodium dodecyl sulfate) achieved hundreds of Pascal. In this investigation, combined surfactants consisting of polysaccharide (gum arabic) and sodium dodecyl sulfate were utilized to stabilize hydrogels with high fracture stress of more than 1 MPa. Moreover, the hydrogels exhibited excellent self-healing capacity and remoldable behavior without any stimulation...
December 1, 2018: Carbohydrate Polymers
Honglei Chen, Junwen Cheng, Luoxiao Ran, Kun Yu, Bitao Lu, Guangqian Lan, Fangying Dai, Fei Lu
Hydrogels with self-healing capacity can undergo self-repair, establishing safer and longer-lasting products. Hydrogel wound dressings showing self-healing capacity can prolong the lifespan of the material and provide better wound protection. Therefore, in this study, Schiff base reactions (reversible imine linkages) were utilized to design injectable self-healing hydrogels with chitosan and konjac glucomannan. Oxidized konjac glucomannan was used to react with chitosan to form hydrogel. In addition to injectable, self-healing properties, the hydrogels also had adhesive and antibacterial properties, were biocompatible, and promoted wound healing...
December 1, 2018: Carbohydrate Polymers
Amal Gharamti, Zeina A Kanafani
Vascular graft infection is a devastating complication of vascular reconstructive surgery. The infection can occur early in the postoperative period and is largely due to intraoperative contamination or by contiguous extension from a nearby infection. It can also occur years after implantation. Staphylococci remain the most common organisms and biofilm production makes eradication difficult. Factors commonly reported to predispose to vascular graft infection are periodontal disease, nasal colonization with Staphylococcus aureus, bacteremia, certain graft characteristics, diabetes mellitus, postoperative hyperglycemia, location of the incision, wound infection, and emergency procedure...
September 18, 2018: Infectious Disease Clinics of North America
Deborah Chicharro, Jose M Carrillo, Mónica Rubio, Ramón Cugat, Belén Cuervo, Silvia Guil, Jerónimo Forteza, Victoria Moreno, Jose M Vilar, Joaquín Sopena
BACKGROUND: The use of Plasma Rich in Growth Factors (PRGF) and Adipose Derived Mesenchymal Stem Cells (ASCs) are today extensively studied in the field of regenerative medicine. In recent years, human and veterinary medicine prefer to avoid using traumatic techniques and choose low or non-invasive procedures. The objective of this study was to evaluate the efficacy of PRGF, ASCs and the combination of both in wound healing of full-thickness skin defects in rabbits. With this purpose, a total of 144 rabbits were used for this study...
September 21, 2018: BMC Veterinary Research
Yutang Wang, Dapeng Tian, Ming Dai
In the aerospace field, compact optoelectronic platforms (COPs) are being increasingly equipped on unmanned aircraft systems (UAS). They assist UAS in a range of mission-specific tasks such as disaster relief, crop testing, and firefighting. However, the strict constraint of structure space makes COPs subject to multi-source disturbances. The application of a low-cost and low-precision sensor also affects the system control performance. A composite hierarchical anti-disturbance control (CHADC) scheme with multisensor fusion is explored herein to improve the motion performance of COPs in the presence of internal and external disturbances...
September 21, 2018: Sensors
Thomas W Carion, Abdul Shukkur Ebrahim, David Kracht, Aditya Agrawal, Eliisa Strand, Omar Kaddurah, Cody R McWhirter, Gabriel Sosne, Elizabeth A Berger
With increasing multidrug resistance and contraindication for corticosteroid use, the goal of this study was to develop thymosin beta-4 (Tβ4) as an adjunctive therapy to antibiotics for the treatment of bacterial keratitis that effectively promotes enhanced wound healing, host defense, and inflammation resolution. Disease outcome was assessed by clinical score, slit lamp photography, and histopathology. Cytokine profile, bacterial load, PMN infiltration, and Griess and reactive oxygen species (ROS) levels were determined...
September 20, 2018: Cells
Emilia Wirth, Lilia Sabantina, Marcus O Weber, Karin Finsterbusch, Andrea Ehrmann
Electrospinning can be used to create nanofiber mats for diverse applications, from wound dressings and tissue engineering to filters for medical and biotechnological applications. In most of these applications, it is necessary to fix the nanofiber mat on a macroscopic textile fabric, on another nanofiber mat or within a frame to keep it at the desired position. Due to their extremely low thickness and areal mass, however, nanofiber mats are easily destroyed by sewing, and in several situations glued bonds are too thick and not flexible enough...
September 20, 2018: Nanomaterials
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