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https://www.readbyqxmd.com/read/29031202/targeting-of-cell-cycle-and-let-7a-stat3-pathway-by-niclosamide-inhibits-proliferation-migration-and-invasion-in-oral-squamous-cell-carcinoma-cells
#1
Xiaoxu Li, Ruiyu Ding, Zewen Han, Zeyun Ma, Yixiang Wang
The low median survival rate of oral squamous cell carcinoma (OSCC) is associated with chemotherapeutic resistance. Niclosamide is an oral anti-helminthic drug, its anti-cancer effect has been reported in recent years. However, the effect of niclosamide on OSCC remains largely unknown. In this study, we, for the first time, investigated the underlying mechanisms from cell cycle arrest and let-7a/STAT3 axis through CCK-8, cell cycle, apoptosis, wound healing, Transwell invasion, generation of stable cell line, real-time PCR, and western blot assays using two OSCC cell lines WSU-HN6 and Tca83...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29031127/patients-perceptions-and-experiences-of-living-with-a-surgical-wound-healing-by-secondary-intention-a-qualitative-study
#2
Dorothy McCaughan, Laura Sheard, Nicky Cullum, Jo Dumville, Ian Chetter
BACKGROUND: Most surgical wounds heal by primary intention, that is to say, the edges of the wound are brought together with sutures, staples, adhesive glue or clips. However, some wounds may be left open to heal (if there is a risk of infection, or if there has been significant tissue loss), and are known as 'surgical wounds healing by secondary intention'. They are estimated to comprise approximately 28% of all surgical wounds and are frequently complex to manage. However, they are under researched and little is known of their impact on patients' lives...
September 28, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29029357/a-pilot-retrospective-study-to-evaluate-two-multi-layer-foam-dressings-for-the-management-of-moderately-exudative-pressure-injuries
#3
Kevin Woo, Jennifer Kasaboski
Prevention and treatment of pressure injuries (PI) is a standard benchmark for quality of care, performance, risk reduction, and patient safety. Foam dressings are designed to wick away a large volume of exudate with minimal lateral movement to prevent periwound skin maceration; this renders foam dressings a popular choice for the treatment of chronic wounds with high to moderate amounts of exudate. In addition, multi-layer foam dressings may have added benefits to alleviate pressure and minimize shear as the dressing materials slide against each other...
October 12, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29029236/first-in-human-experience-with-complete-integration-of-neuromodulation-device-within-a-customized-cranial-implant
#4
Chad R Gordon, Gabriel F Santiago, Judy Huang, Gregory K Bergey, Shuya Liu, Mehran Armand, Henry Brem, William S Anderson
BACKGROUND: Neuromodulation devices have the potential to transform modern day treatments for patients with medicine-resistant neurological disease. For instance, the NeuroPace System (NeuroPace Inc, Mountain View, California) is a Food and Drug Administration (FDA)-approved device developed for closed-loop direct brain neurostimulation in the setting of drug-resistant focal epilepsy. However, current methods require placement either above or below the skull in nonanatomic locations. This type of positioning has several drawbacks including visible deformities and scalp pressure from underneath leading to eventual wound healing difficulties, micromotion of hardware with infection, and extrusion leading to premature explantation...
October 6, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29028798/obstructive-sleep-apnea-and-rhonchopathy-are-associated-with-downregulation-of-trefoil-factor-family-peptide-3-tff3-implications-of-changes-in-oral-mucus-composition
#5
Regina Siber-Hoogeboom, Martin Schicht, Sebastian Hoogeboom, Friedrich Paulsen, Maximilian Traxdorf
STUDY OBJECTIVES: Trefoil factor family (TFF) peptides belong to the family of mucin-associated peptides and are expressed in most mucosal surfaces. TFF peptides carry out functions such as proliferation and migration enhancement, anti-apoptosis, and wound healing. Moreover, TFFs are associated with mucins and interact with them as "linker peptides", thereby influencing mucus viscosity. To test the hypothesis that in rhonchopathy and obstructive sleep apnea (OSA) changes occur in the expression of TFF3 and -2 that could contribute to changes in mucus viscosity, leading to an increase in upper airway resistance during breathing...
2017: PloS One
https://www.readbyqxmd.com/read/29028651/endoscopic-conduit-harvest-in-coronary-artery-bypass-grafting-surgery-an-ismics-systematic-review-and-consensus-conference-statements
#6
Francis D Ferdinand, John K MacDonald, Husam H Balkhy, Gianluigi Bisleri, Ho Young Hwang, Patricia Northrup, Richard H J Trimlett, Lai Wei, Bob B Kiaii
OBJECTIVE: The purpose of this consensus conference was to develop and update evidence-informed consensus statements and recommendations on harvesting saphenous vein and radial artery via an open as compared with endoscopic technique by systematically reviewing and performing a meta-analysis of randomized and nonrandomized clinical trials. METHODS: All randomized controlled trials and nonrandomized controlled trials included in the first the International Society for Minimally Invasive Cardiothoracic Surgery Consensus Conference and Statements, in 2005 up to November 30, 2015, were included in a systematic review and meta-analysis...
October 13, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29028587/chemical-constituents-and-medical-benefits-of-plantago-major
#7
REVIEW
Muhammad Bahrain Adom, Muhammad Taher, Muhammad Fathiy Mutalabisin, Mohamad Shahreen Amri, Muhammad Badri Abdul Kudos, Mohd Wan Azizi Wan Sulaiman, Pinaki Sengupta, Deny Susanti
The medicinal benefits of Plantago major have been acknowledged around the world for hundreds of years. This plant contains a number of effective chemical constituents including flavonoids, alkaloids, terpenoids, phenolic acid derivatives, iridoid glycosides, fatty acids, polysaccharides and vitamins which contribute to its exerting specific therapeutic effects. Correspondingly, studies have found that Plantago major is effective as a wound healer, as well as an antiulcerative, antidiabetic, antidiarrhoeal, anti-inflammatory, antinociceptive, antibacterial, and antiviral agent...
October 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29028545/penicillium-expansum-compatible-and-penicillium-digitatum-non-host-pathogen-infection-differentially-alter-ethylene-biosynthesis-in-apple-fruit
#8
Laura Vilanova, Núria Vall-Llaura, Rosario Torres, Josep Usall, Neus Teixidó, Christian Larrigaudière, Jordi Giné-Bordonaba
The role of ethylene on inducing plant resistance or susceptibility to certain fungal pathogens clearly depends on the plant pathogen interaction with little or no-information available focused on the apple-Penicillium interaction. Taken advantage that Penicillium expansum is the compatible pathogen and P. digitatum is the non-host of apples, the present study aimed at deciphering how each Penicillium spp. could interfere in the fruit ethylene biosynthesis at the biochemical and molecular level. The infection capacity and different aspects related to the ethylene biosynthesis were conducted at different times post-inoculation...
September 30, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29028422/enterococcus-faecalis-endophthalmitis-in-children-a-21-year-study
#9
Ekta Rishi, Pukhraj Rishi, Pramod Bhende, Rajiv Raman, Parveen Sen, Pradeep Susvar, Chetan Rao, Lily Therese, Rajshri Hirawat
PURPOSE: To report Enterococcus faecalis endophthalmitis (EFE) in children and its comparison with adults. METHODS: Retrospective study of 19 children up to 18 years age, undergoing vitrectomy for EFE at a referral eye center from January 1995 to December 2015. The results were compared to 18 adults with EFE. RESULTS: The mean age was 7.4 ± 3.06 years. Post-traumatic EFE was seen in 17 (89.4%) children (p < 0.05) versus postoperative EFE seen in 12 (66%) adults...
October 13, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29028413/initial-assessment-treatment-and-follow-up-of-minor-pediatric-burn-wounds-in-four-patients-remotely-a-preliminary-communication
#10
Marek A Paul, Parisa Kamali, Ahmed M S Ibrahim, Caroline Medin, Bernard T Lee, Samuel J Lin
BACKGROUND: Close, multidisciplinary collaboration with burn experts is the essential strategy to achieve the best functional and esthetic outcomes in burn wound treatment. Management of minor burn injuries, where no specialized care is available, might be challenging. One concept to achieve a fast and timely result is the application of telemedicine. The objective of this study was to assess and develop a simple telemedicine protocol, which can be applied globally. MATERIAL AND METHODS: We present a pilot study based on a pediatric population of four patients with minor burns...
October 13, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29028315/nanoparticles-of-short-cationic-peptidopolysaccharide-self-assembled-by-hydrogen-bonding-with-antibacterial-effect-against-multi-drug-resistant-bacteria
#11
Zheng Hou, Yogesh Vikhe Shankar, Yang Liu, Feiqing Ding, Jothy Lachumy Subramanion, Vikashini Ravikumar, Rubí Zamudio-Vázquez, Damien Keogh, Huiwen Lim, Moon Yue Feng Tay, Surajit Bhattacharjya, Scott A Rice, Jian Shi, Hongwei Duan, Xue-Wei Liu, Yuguang Mu, Nguan Soon Tan, Kam Michael Chiu Tam, Kevin Pethe, Mary B Chan-Park
Cationic antimicrobial peptides (AMPs) and polymers are active against many multi-drug resistant (MDR) bacteria but only a limited number of these compounds are in clinical use due to their unselective toxicity. The typical strategy for achieving selective antibacterial efficacy with low mammalian cell toxicity is through balancing the ratio of cationicity to hydrophobicity. Herein, we report a cationic nanoparticle self-assembled from chitosan-graft-oligolysine (CSM5-K5) chains with ultra-low molecular weight (1450 Daltons) that selectively kills bacteria...
October 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29028086/downregulation-of-microrna-645-suppresses-breast-cancer-cell-metastasis-via-targeting-dcdc2
#12
Y Cai, W-F Li, Y Sun, K Liu
OBJECTIVE: To analyze the functioning mode of miR-645 on breast cancer cell metastasis and provide therapeutic targets for breast cancer. MATERIALS AND METHODS: Quantitative Real-time PCR (qRT-PCR) assay was employed to detect miR-645 expression level. Wound healing assay and transwell assay were performed to investigate metastasis capacity of breast cancer cells. Protein levels were assessed by Western blotting assay. The target gene was predicted and verified by bioinformatics analysis and luciferase assay...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29027867/unplanned-readmission-within-90-days-after-pediatric-neurosurgery
#13
Silky Chotai, Bradley S Guidry, Emily W Chan, Katherine D Sborov, Stephen Gannon, Chevis Shannon, Christopher M Bonfield, John C Wellons, Robert P Naftel
OBJECTIVE Readmission and return to operating room after surgery are increasingly being used as a proxy for quality of care. Nearly 60% of these readmissions are unplanned, which translates into billions of dollars in health care costs. The authors set out to analyze the incidence of readmission at their center, to define causes of unplanned readmission, and to determine the preoperative and surgical variables associated with readmissions following pediatric neurosurgery. METHODS A total of 536 children who underwent operations for neurosurgical diagnoses between 2012 and 2015 and who were later readmitted were included in the final analysis...
October 13, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29027375/vibrio-vulnificus-new-insights-into-a-deadly-opportunistic-pathogen
#14
Craig Baker-Austin, James D Oliver
Vibrio vulnificus is a Gram-negative aquatic bacterium first isolated by the United States (US) Centers for Disease Control and Prevention (CDC) in 1964. This bacterium is part of the normal microbiota of estuarine waters and occurs in high numbers in molluscan shellfish around the world, particularly in warmer months. Infections in humans are derived from consumption of seafood produce and from water exposure. V. vulnificus is a striking and enigmatic human pathogen, yet many aspects related to its biology, genomics, virulence capabilities and epidemiology remain elusive and poorly understood...
October 13, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/29027222/alarmins-and-immunity
#15
REVIEW
De Yang, Zhen Han, Joost J Oppenheim
More than a decade has passed since the conceptualization of the "alarmin" hypothesis. The alarmin family has been expanding in terms of both number and the concept. It has recently become clear that alarmins play important roles as initiators and participants in a diverse range of physiological and pathophysiological processes such as host defense, regulation of gene expression, cellular homeostasis, wound healing, inflammation, allergy, autoimmunity, and oncogenesis. Here, we provide a general view on the participation of alarmins in the induction of innate and adaptive immune responses, as well as their contribution to tumor immunity...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29027034/low-intensity-led-therapy-%C3%AE-640%C3%A2-%C3%A2-%C3%A2-20%C3%A2-nm-on-saphenectomy-healing-in-patients-who-underwent-coronary-artery-bypass-graft-a-randomized-double-blind-study
#16
Raimundo de Barros Araújo Júnior, Isabel Clarisse Albuquerque Gonzaga, Gilderlene Alves Fernandes, Andréa Conceição Gomes Lima, Paulo Sergio Tajra Cortelazzi, Rauirys Alencar de Oliveira, Renata Amadei Nicolau
Myocardial revascularization surgery (CABG) is the most appropriate treatment for coronary artery disease. Currently, the great challenge is to reduce postoperative complications, such as wound infections, dehiscence, pain, and patients' quality of life. The saphenectomy is the target of complications in 10% of cases, which can cause greater morbidity, time, and cost of hospitalization. Studies show that low-intensity laser or light-emitted diode (LED) therapy promotes positive biomodulation of the tissue repair process, culminating in a lower incidence of dehiscence, pain reduction, and improvement in quality of life...
October 13, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29026962/abdominal-contouring-outcomes-in-class-iii-obesity-analysis-of-the-acs-nsqip-database
#17
Husain T AlQattan, Leela S Mundra, Gustavo A Rubio, Seth R Thaller
BACKGROUND: Obesity may increase the risk of complications following abdominal contouring. The aim of this study is to evaluate panniculectomy outcomes in patients with class III obesity (BMI > 40 kg/m(2)). METHODS: The American College of Surgeon's National Surgical Quality Improvement Program ACS-NSQIP (2010-2014) was used to identify patients who underwent panniculectomy. Class III obesity patients were identified. Demographics, comorbidities and postoperative outcomes were evaluated...
October 12, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29026866/a-prospective-observational-study-of-the-epidemiology-management-and-outcomes-of-skin-and-soft-tissue-infections-due-to-carbapenem-resistant-enterobacteriaceae
#18
Oryan Henig, Eric Cober, Sandra S Richter, Federico Perez, Robert A Salata, Robert C Kalayjian, Richard R Watkins, Steve Marshall, Susan D Rudin, T Nicholas Domitrovic, Andrea M Hujer, Kristine M Hujer, Yohei Doi, Scott Evans, Vance G Fowler, Robert A Bonomo, David van Duin, Keith S Kaye
BACKGROUND: This study was performed to characterize the epidemiology, management, and outcomes of skin and soft tissue infection (SSTI) and colonization due to carbapenem-resistant Enterobacteriaceae (CRE). METHODS: Patients from the Consortium on Resistance Against Carbapenem in Klebsiella and Other Enterobacteriaceae (CRACKLE-1) from December 24, 2011 to October 1, 2014 with wound cultures positive for CRE were included in the study. Predictors of surgical intervention were analyzed...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29026816/aesthetic-refinements-in-forehead-flap-reconstruction-of-the-asian-nose
#19
Yen-Chang Hsiao, Chun-Shin Chang, Jonathan Zelken
BACKGROUND: Traditional paramedian forehead flap reconstruction exploits the aesthetic subunit principle. Refinements and outcomes of forehead flap nasal reconstruction largely reflect Western experience. Differences in ethnic Asian anatomy and wound healing may foster suboptimal outcomes. We modified methods to address Asian features by extending subunit and flap boundaries, minimizing flap thinning, and overbuilding the nasal framework to combat contraction and suboptimal scarring. METHODS: Between November 2010 and September 2015, 40 Asians were treated for nasal reconstruction with a modified forehead flap technique...
May 2017: Plastic Surgery
https://www.readbyqxmd.com/read/29026808/low-frequency-ultrasound-debridement-in-chronic-wound-healing-a-systematic-review-of-current-evidence
#20
Ying-Ju Ruby Chang, Julie Perry, Karen Cross
Chronic wounds are painful and debilitating to patients, pose a clinical challenge to physicians, and impose financial burden on the health-care system. New treatment options are therefore highly sought after. Ultrasound debridement is a promising technology that functions to disperse bacterial biofilms and stimulate wound healing. In this review, we focus on low-frequency ultrasound (20-60 kHz) and summarize the findings of 25 recent studies examining ultrasound efficacy. Ultrasound debridement appears to be most effective when used 3 times a week and has the potential to decrease exudate and slough, decrease patient pain, disperse biofilms, and increase healing in wounds of various etiology...
February 2017: Plastic Surgery
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