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Mucuna pruriens

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https://www.readbyqxmd.com/read/27919828/mucuna-pruriens-reduces-inducible-nitric-oxide-synthase-expression-in-parkinsonian-mice-model
#1
Satyndra Kumar Yadav, Sachchida Nand Rai, Surya Pratap Singh
Parkinson's disease is one of the most common neurodegenerative disease found in aged peoples. Plentiful studies are being conducted to find a suitable and effective cure for this disease giving special impetus on use of herbal plants. The study aimed at investigating the effect of ethanolic extract of Mucuna pruriens (Mp) on level of nitric oxide (NO) in paraquat (PQ) induced Parkinson's disease (PD) mouse model and its subsequent contribution to lipid peroxidation. Twenty four Swiss albino mice were divided into three groups; Control, PQ and PQ+Mp...
December 2, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27897091/inducing-mutations-through-%C3%AE-irradiation-in-seeds-of-mucuna-pruriens-for-developing-high-l-dopa-yielding-genotypes
#2
Susheel Kumar Singh, Deepti Yadav, Raj Kishori Lal, Madan M Gupta, Sunita Singh Dhawan
PURPOSE: To develop elite genotypes in Mucuna pruriens (L.) DC with high L-DOPA (L-3, 4 dihydroxyphenylalanine) yields, with non-itching characteristics and better adaptability by applying γ-irradiation. Molecular and chemical analysis was performed for screening based on specific characteristics desired for developing suitable genotypes. MATERIALS AND METHODS: Developed, mutant populations were analyzed for L-DOPA % in seeds through TLC (thin layer chromatography), and the results obtained were validated with the HPLC (High performance liquid chromatography)...
November 29, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27893308/evaluation-of-hypotensive-and-antihypertensive-effects-of-velvet-bean-mucuna-pruriens-l-hydrolysates
#3
Luis Chel-Guerrero, Saulo Galicia-Martínez, Juan José Acevedo-Fernández, Jesus Santaolalla-Tapia, David Betancur-Ancona
Hypertension could cause significant worldwide health problems that affect 15-20% of all adults; according to National Health and Nutrition Examination Survey, about 29% of the adult population in the United States are hypertensive. Recent research has shown that peptides derived from the hydrolysis of food proteins can decrease blood pressure. This study was carried out to evaluate the hypotensive and antihypertensive potential of Mucuna pruriens protein hydrolysates in in vitro and in vivo models. M. pruriens protein concentrate was prepared by wet fractionation and enzymatically hydrolyzed using Alcalase(®), Flavourzyme(®), and the sequential system Alcalase-Flavourzyme at different times (5-120 min)...
November 28, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27811447/appraisal-on-the-wound-healing-activity-of-different-extracts-obtained-from-aegle-marmelos-and-mucuna-pruriens-by-in-vivo-experimental-models
#4
F A Toppo, R S Pawar
AIM: The use of a simple and reproducible model is inevitable for an objective statement of the effects of external factors on wound healing. Hence, the present study was conducted to evaluate wound healing activities of sequential different extracts of Aegle marmelos leaves (AM) and Mucuna pruriens seeds (MP) by in vivo experimental models. MATERIALS AND METHODS: Wistar albino rats were subjected to excision, incision and dead space wounds measuring approximately 250 mm2, 3 cm and implanting sterilized polyvinyl chloride tube on the back of each rat near either side of the vertebral column respectively...
November 2016: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/27693453/development-of-a-neuroprotective-potential-algorithm-for-medicinal-plants
#5
Weixi Liu, Hang Ma, Nicholas A DaSilva, Kenneth N Rose, Shelby L Johnson, Lu Zhang, Chunpeng Wan, Joel A Dain, Navindra P Seeram
Medicinal plants are promising candidates for Alzheimer's disease (AD) research but there is lack of systematic algorithms and procedures to guide their selection and evaluation. Herein, we developed a Neuroprotective Potential Algorithm (NPA) by evaluating twenty-three standardized and chemically characterized Ayurvedic medicinal plant extracts in a panel of bioassays targeting oxidative stress, carbonyl stress, protein glycation, amyloid beta (Aβ) fibrillation, acetylcholinesterase (AChE) inhibition, and neuroinflammation...
September 29, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27681644/an-evidence-based-approach-to-medicinal-plants-for-the-treatment-of-sperm-abnormalities-in-traditional-persian-medicine
#6
REVIEW
M Tahvilzadeh, M Hajimahmoodi, T Toliyat, M Karimi, R Rahimi
Infertility is defined as inability of a sexually active couple to conceive after 1 year of regular intercourse without contraception. Male factors account for 20%-50% of cases of infertility. The aim of this study was to review medicinal plants that proposed to improve sperm abnormalities in traditional Persian medicine. For this purpose, PubMed, Scopus, GoogleScholar and Cochrane library were explored for medicinal plants used in traditional Persian medicine for sperm abnormalities to obtain studies giving any evidence for their efficacy and pharmacological mechanisms related to male infertility...
October 2016: Andrologia
https://www.readbyqxmd.com/read/27651261/indian-herbs-for-the-treatment-of-neurodegenerative-disease
#7
Padmanabhan Mannangatti, Kamalakkannan Narasimha Naidu
Ayurveda, an ancient system of medicine that is indigenous to India, is believed to be the world's oldest comprehensive health-care system and is now one of the most recognized and widely practiced disciplines of alternative medicine in the world. Medicinal herbs have been in use for treating diseases since ancient times in India. Ayurvedic therapies with medicinal herbs and herbomineral products generally provide relief without much adverse effects even after prolonged administration. Neurodegenerative disorders are a major cause of mortality and disability, and increasing life spans represent one of the key challenges of medical research...
2016: Advances in Neurobiology
https://www.readbyqxmd.com/read/27561457/comparative-evaluation-of-the-sexual-functions-and-nf-%C3%AE%C2%BAb-and-nrf2-pathways-of-some-aphrodisiac-herbal-extracts-in-male-rats
#8
Kazim Sahin, Cemal Orhan, Fatih Akdemir, Mehmet Tuzcu, Hasan Gencoglu, Nurhan Sahin, Gaffari Turk, Ismet Yilmaz, Ibrahim H Ozercan, Vijaya Juturu
BACKGROUND: Mucuna pruriens, Tribulus terrestris and Ashwagandha (Withania somnifera) are widely known as antioxidant effective herbals and have been reported to possess aphrodisiac activities in traditional usages. In this study, we determined the effects of these herbals on sexual functions, serum biochemical parameters, oxidative stress and levels of NF-κB, Nrf2, and HO-1 in reproductive tissues. METHODS: Thirty-five male rats were divided into five groups: the control group, sildenafil-treated group (5 mg/kg/d), Mucuna, Tribulus and Ashwagandha groups...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27544001/management-of-parkinson-s-disease-in-ayurveda-medicinal-plants-and-adjuvant-measures
#9
Namyata Pathak-Gandhi, Ashok D B Vaidya
ETHNOPHARMACOLOGICAL RELEVANCE: Medicinal plants like Mucuna pruriens L.(DC) and Withania somnifera L.(Dunal) have been used in traditional Ayurvedic medicine to manage neurodegenerative diseases like Parkinson's disease. AIM: The aim of this review is to share the role of Ayurveda's insights, traditional usage and contemporary investigations for translational, integrative applications to manage Idiopathic Parkinson's Disease. MATERIALS AND METHODS: High impact journals for Parkinson's diseases, traditional textbooks from Ayurveda as well as relevant clinical and para clinical studies with botanicals are selectively incorporated to evolve the aforesaid translational application...
August 17, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27478210/dehulling-reduces-toxicity-and-improves-in-vivo-biological-value-of-proteins-in-vegetal-milk-derived-from-two-mucuna-mucuna-pruriens-l-seeds-varieties
#10
Yannick Dimitry Mang, Yanou Nicolas Njintang, Bouba Armand Abdou, Joel Scher, Clémence Bernard, Moses C Mbofung
The present work was carried out to evaluate the nutritive quality (proximate and antinutrients composition) of vegetable milks prepared from whole and dehulled mucuna bean flours. Casein and mucuna milk diets were fed to rats (four weeks old; n = 8 per group) for 28 days to determine protein efficiency ratio (PER), net protein efficiency ratio (NPER), true and apparent digestibility (TD and AD, respectively), organ-to-body weight ratios and hematological parameters. The experimental design was a factorial design with two variety of mucuna (cochinchinensis and veracruz) and two treatments (whole and dehulled beans)...
June 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27446635/dry-matter-production-nutrient-cycled-and-removed-and-soil-fertility-changes-in-yam-based-cropping-systems-with-herbaceous-legumes-in-the-guinea-sudan-zone-of-benin
#11
Raphiou Maliki, Brice Sinsin, Anne Floquet, Denis Cornet, Eric Malezieux, Philippe Vernier
Traditional yam-based cropping systems (shifting cultivation, slash-and-burn, and short fallow) often result in deforestation and soil nutrient depletion. The objective of this study was to determine the impact of yam-based systems with herbaceous legumes on dry matter (DM) production (tubers, shoots), nutrients removed and recycled, and the soil fertility changes. We compared smallholders' traditional systems (1-year fallow of Andropogon gayanus-yam rotation, maize-yam rotation) with yam-based systems integrated herbaceous legumes (Aeschynomene histrix/maize intercropping-yam rotation, Mucuna pruriens/maize intercropping-yam rotation)...
2016: Scientifica
https://www.readbyqxmd.com/read/27436912/assessment-of-genetic-diversity-in-mucuna-species-of-india-using-randomly-amplified-polymorphic-dna-and-inter-simple-sequence-repeat-markers
#12
Ravishankar R Patil, Kiran D Pawar, Manali R Rane, Shrirang R Yadav, Vishwas A Bapat, Jyoti P Jadhav
Genus Mucuna which is native to China and Eastern India comprises of perennial climbing legume with long slender branches, trifoliate leaves and bear green or brown pod covered with soft or rigid hairs that cause intense irritation. The plants of this genus are agronomically and economically important and commercially cultivated in India, China and other regions of the world. The high degrees of taxonomical confusions exist in Mucuna species that make authentic identification and classification difficult. In the present study, the genetic diversity among the 59 accessions of six species and three varieties of M...
April 2016: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/27333543/rapid-electrochemical-method-for-the-determination-of-l-dopa-in-extract-from-the-seeds-of-mucuna-prurita
#13
Dalibor M Stankovič, Anchalee Samphao, Biljana Dojcinović, Kurt Kalcher
This work presents the electrochemical behavior of levodopa (L-DOPA), at boron-doped diamond (BDD) electrodes, using cycling voltammetry (CV), in Britton-Robinson (BR) buffer solution, and application of the proposed electrode for the determination of L-DOPA in extracts from the seeds of velvet bean (Mucuna prurita Hook or Mucuna pruriens (L.) DC.). L-DOPA provides a well-defined and single oval-shape oxidation peak at +0.8 V vs. Ag/AgCl (3 M KCl) reference electrode in BR buffer solution at pH 3.0. Experimental parameters, such as pH of supporting electrolyte and square wave voltammetry (SWV) operating parameters (frequency and modulation amplitude) were optimized...
2016: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/27206902/mucuna-pruriens-for-parkinson-s-disease-low-cost-preparation-method-laboratory-measures-and-pharmacokinetics-profile
#14
Erica Cassani, Roberto Cilia, Janeth Laguna, Michela Barichella, Manuela Contin, Emanuele Cereda, Ioannis U Isaias, Francesca Sparvoli, Albert Akpalu, Kwabena Ofosu Budu, Maria Teresa Scarpa, Gianni Pezzoli
BACKGROUND: Parkinson's disease (PD) is a progressive neurological condition. Levodopa (LD) is the gold standard therapy for PD patients. Most PD patients in low-income areas cannot afford long-term daily Levodopa therapy. The aim of our study was to investigate if Mucuna pruriens (MP), a legume with high LD content that grows in tropical regions worldwide, might be potential alternative for poor PD patients. METHODS: We analyzed 25 samples of MP from Africa, Latin America and Asia...
June 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27019430/genetic-mapping-and-qtl-analysis-of-agronomic-traits-in-indian-mucuna-pruriens-using-an-intraspecific-f%C3%A2-population
#15
S Mahesh, M Leelambika, Md Jaheer, A M Anithakumari, N Sathyanarayana
Mucuna pruriens is a well-recognized agricultural and horticultural crop with important medicinal use. However, antinutritional factors in seed and adverse morphological characters have negatively affected its cultivation. To elucidate the genetic control of agronomic traits, an intraspecific genetic linkage map of Indian M. pruriens has been developed based on amplified fragment length polymorphism (AFLP) markers using 200 F₂ progenies derived from a cross between wild and cultivated genotypes. The resulting linkage map comprised 129 AFLP markers dispersed over 13 linkage groups spanning a total distance of 618...
March 2016: Journal of Genetics
https://www.readbyqxmd.com/read/26987900/mp-4-contributes-to-snake-venom-neutralization-by-mucuna-pruriens-seeds-through-an-indirect-antibody-mediated-mechanism
#16
Ashish Kumar, Chitra Gupta, Deepak T Nair, Dinakar M Salunke
Mortality due to snakebite is a serious public health problem, and available therapeutics are known to induce debilitating side effects. Traditional medicine suggests that seeds of Mucuna pruriens can provide protection against the effects of snakebite. Our aim is to identify the protein(s) that may be important for snake venom neutralization and elucidate its mechanism of action. To this end, we have identified and purified a protein from M. pruriens, which we have named MP-4. The full-length polypeptide sequence of MP-4 was obtained through N-terminal sequencing of peptide fragments...
May 20, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26928470/development-and-validation-of-an-lc-ms-ms-method-for-simultaneous-quantification-of-levodopa-and-md01-in-rat-plasma-and-its-application-to-a-pharmacokinetic-study-of-mucuna-pruriens-extract
#17
Guangjie Yang, Fangrong Zhang, Linfang Deng, Chang Chen, Zhongzhe Cheng, Jiangeng Huang, Jiangyun Liu, Hongliang Jiang
Mucuna pruriens, an ancient Indian herbal medicine containing levodopa, is widely used for Parkinson's disease. In order to simultaneously determine levodopa and 1,1-dimethyl-3-carboxy-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (MD01) in rat plasma, an improved LC-MS/MS method was developed and validated for a pharmacokinetic study in rats orally administered levodopa or Mucuna pruriens extract (MPE). Elimination of matrix effect and improvement of extraction recovery were achieved through systematic optimization of reversed-phase and hydrophilic interaction chromatographic conditions together with sample clean-up procedures...
September 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/26854846/potential-therapeutic-applications-of-mucuna-pruriens-peptide-fractions-purified-by-high-performance-liquid-chromatography-as-angiotensin-converting-enzyme-inhibitors-antioxidants-antithrombotic-and-hypocholesterolemic-agents
#18
Francisco Herrera-Chalé, Jorge Carlos Ruiz-Ruiz, David Betancur-Ancona, Maira Rubi Segura-Campos
A Mucuna pruriens protein concentrate was hydrolyzed with a digestive (pepsin-pancreatin) enzymatic system. The soluble portion of the hydrolysate was fractionated by ultrafiltration and the ultrafiltered peptide fraction (PF) with lower molecular weight was purified by reversed-phase high-performance liquid chromatography. The PF obtained were evaluated by testing the biological activity in vitro. Fractions showed that the ability to inhibit the angiotensin-converting enzyme had IC50 values that ranged from 2...
February 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/26810548/effects-of-soybean-ingestion-on-pharmacokinetics-of-levodopa-and-motor-symptoms-of-parkinson-s-disease-in-relation-to-the-effects-of-mucuna-pruriens
#19
Yasuhiro Nagashima, Tomoyoshi Kondo, Mayumi Sakata, Jinsoo Koh, Hidefumi Ito
Mucuna pruriens is a levodopa-containing legume and its favorable effects on motor complications in Parkinson disease patients have been reported. The aim of this study was to investigate the effects of another legume, soybeans, on the pharmacokinetics and metabolism of levodopa. Seven parkinsonian patients with the wearing-off phenomenon and dyskinesia and five healthy volunteers participated in this study. We conducted a crossover study of the clinical effects on the participants before and after taking either levodopa (100mg)/carbidopa (10mg) only (LD/CD) or levodopa/carbidopa with 11 g of ground soybeans (LD/CD/soy)...
February 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/26787938/optimization-of-vegetable-milk-extraction-from-whole-and-dehulled-mucuna-pruriens-var-cochinchinensis-flours-using-central-composite-design
#20
Dimitry Y Mang, Armand B Abdou, Nicolas Y Njintang, Edith J M Djiogue, Emmanuel A Panyo, Clemence Bernard, Robert Ndjouenkeu, Benoît B Loura, Carl M F Mbofung
Extraction conditions for maximum values of protein yield, protein content, sugar content and dry matter of vegetable milk extracts from dehulled Mucuna cochinchinensis bean flour and whole Mucuna cochinchinensis bean flour were investigated using response surface methodology. A Central Composite Design (CCFD) with three factors: temperature (25 to 95 °C); extraction time (6 to 74 min.) and water to flour ratio (6 to 24 mL/g) were used. Data analysis showed that all the factors significantly (p < 0...
January 2016: Journal of Food Science and Technology
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