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Mucuna pruriens

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https://www.readbyqxmd.com/read/29694496/persistence-of-auxinic-herbicides-applied-on-pasture-and-toxicity-for-succeeding-crops
#1
Arnon H C Anésio, Márcia V Santos, Raul R Silveira, Evander A Ferreira, José B Dos Santos, Leandro D DA Silva
The aim of this work was to determine the persistence of auxinic herbicides applied on tropical pasture and toxicity for succeeding crops. The herbicides were applied in an area of dystrophic red‒yellow latosol with pasture infested of weeds. At 40, 80, and 280 days after application of herbicide, the soil samples were collected at depths of 0 to 20 cm. Soil with residues of 2,4-D, 2,4-D + picloram, triclopyr, and a soil without herbicide application were analyzed with six replicates. Seven crops were cultivated in these soils: cucumber (Cucumis sativus L...
April 23, 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29691792/effect-of-enzymatic-digestion-of-protein-derivatives-obtained-from-mucuna-pruriens-l-on-production-of-proinflammatory-mediators-by-balb-c-mouse-macrophages
#2
Edwin E Martínez Leo, Victor E Arana Argáez, Juan J Acevedo Fernández, Rosa Moo Puc, Maira R Segura Campos
Inflammation is considered to be a major risk factor for the pathogenesis of chronic non-communicable diseases. Macrophages are important immune cells, which regulate inflammation and host defense by secretion of proinflammatory mediators. Obtaining biopeptides by enzymatic hydrolysis adds value to proteins of vegetative origin, such as Mucuna pruriens L. The present study evaluated the effect of enzymatic digestion of protein derivatives obtained from M. pruriens L. on the production of proinflammatory mediators by BALB/c mouse macrophages...
April 25, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29589192/utilization-of-mucuna-pruriens-whole-pods-to-feed-lactating-hair-ewes
#3
Irina Nadieska Peniche-Gonzalez, Luis Armando Sarmiento-Franco, Ronald Herve Santos-Ricalde
Twenty nine Pelibuey × Katahdin hair ewes rearing single lamb were used during 42 days of lactation to evaluate the effect of including the Mucuna pruriens whole pods in the diets of lactating ewes on milk production and offspring performance. Animals were distributed at random into three experimental diets: a control diet without Mucuna (M0), and two more diets with the inclusion of 13 (M13) and 26% (M26), of milled pods of Mucuna pruriens, respectively. Dry matter intake, was not significantly different (P > 0...
March 27, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29537908/comparative-effects-of-l-dopa-and-velvet-bean-seed-extract-on-soybean-lignification
#4
Graciene de Souza Bido, Hingrid Ariane da Silva, Tiara da Silva Coelho Bortolo, Marcos Rodrigues Maldonado, Rogério Marchiosi, Wanderley Dantas Dos Santos, Osvaldo Ferrarese-Filho
Velvet bean (Mucuna pruriens) is an efficient cover forage that controls weeds, pathogens and nematodes, and the non-protein amino acid L-3,4-dihydroxyphenylalanine (L-DOPA) is its main allelochemical. The effects of 3 g L-1 of an aqueous extract of velvet bean seeds, along with 0.5 mM L-DOPA for comparison, were evaluated in roots, stems and leaves of soybean (Glycine max). The activities of phenylalanine ammonia lyase (PAL) and cinnamyl alcohol dehydrogenase (CAD) were determined, along with the lignin content and its monomeric composition...
April 3, 2018: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/29458093/protective-efficacy-of-mucuna-pruriens-l-seed-meal-enriched-diet-on-growth-performance-innate-immunity-and-disease-resistance-in-oreochromis-mossambicus-against-aeromonas-hydrophila
#5
Mohamed Saiyad Musthafa, Syed Mohideen Asgari, Amitha Kurian, Preetham Elumalai, Abdul Rahman Jawahar Ali, Bilal Ahmad Paray, Mohammad K Al-Sadoon
The impact of Mucuna pruriens (L.) seed meal diet on growth performance, innate immune response, and disease resistance in Oreochromis mossambicus against Aeromonas hydrophila is reported for the first time. Infected O. mossambicus was fed with 2 g kg-1 , 4 g kg-1 , and 6 g kg-1 of M. pruriens seed meal diets significantly increased initial body weight (IBW) and final body weight (FBW) over control, for a period of 4 weeks. At 4 g kg-1 and 6 g kg-1 the enriched diet significantly (P < 0.05) enhanced the survival rate, weight gain (WG), protein efficiency ratio (PER), specific growth rate (SGR), feed conversion ratio (FCR), and feed efficiency (FE) when compared to the control; besides, from weeks 2-4 these diets significantly (P < 0...
April 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29447189/drought-response-of-mucuna-pruriens-l-dc-inoculated-with-acc-deaminase-and-iaa-producing-rhizobacteria
#6
Aansa Rukya Saleem, Cecilia Brunetti, Azeem Khalid, Gianni Della Rocca, Aida Raio, Giovanni Emiliani, Anna De Carlo, Tariq Mahmood, Mauro Centritto
Drought is one of the major constraints limiting agricultural production worldwide and is expected to increase in the future. Limited water availability causes significant effects to plant growth and physiology. Plants have evolved different traits to mitigate the stress imposed by drought. The presence of plant growth-promoting rhizobacteria (PGPR) could play an important role in improving plant performances and productivity under drought. These beneficial microorganisms colonize the rhizosphere of plants and increase drought tolerance by lowering ethylene formation...
2018: PloS One
https://www.readbyqxmd.com/read/29447059/therapeutic-potential-of-mucuna-pruriens-linn-on-ageing-induced-damage-in-dorsal-nerve-of-the-penis-and-its-implication-on-erectile-function-an-experimental-study-using-albino-rats
#7
Prakash Seppan, Ibrahim Muhammed, Karthik Ganesh Mohanraj, Ganesh Lakshmanan, Dinesh Premavathy, Sakthi Jothi Muthu, Khayinmi Wungmarong Shimray, Sathya Bharathy Sathyanathan
OBJECTIVE: To study the effect of ethanolic seed extract of Mucuna pruriens on damaged dorsal nerve of the penis (DNP) in aged rat in relation to penile erection. METHODS: The rats were divided into four groups Young (3 months), Aged (24 - 28 months), Aged + M. pruriens, and Young + M. pruriens (200 mg/kg b.w/60 days) and were subjected to the hypophysial - gonadal axis, nerve conduction velocity (NCV), and penile reflex. DNP sections were stained with nitric oxide synthase (nNOS), nicotinamide adenine dinucleotide phosphate (NaDPH) diaphorase, androgen receptor (AR), and osmium tetroxide...
February 15, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29446788/the-potential-role-of-herbal-products-in-the-treatment-of-parkinson-s-disease
#8
M S Amro, S L Teoh, A G Norzana, D Srijit
Parkinson's disease (PD) is a multifactorial disorder of the nervous system in which there is a progressive loss of dopaminergic neurons. There is a disturbance in the movement in PD and these include resting tremors, rigidity, bradykinesia or akinesia, disturbance, posture and freezing (motor block). The substantia nigra and other parts of the brain are commonly affected. The disorder could be related to oxidative stress and there is an important role of reactive oxygen species (ROS). A number of herbal products contain active components which are known to possess antioxidant action...
January 2018: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29427634/mucuna-pruriens-l-dc-chemo-sensitize-human-breast-cancer-cells-via-downregulation-of-prolactin-mediated-jak2-stat5a-signaling
#9
Sonam Sinha, Sonal Sharma, Jaykant Vora, Heta Shah, Anshu Srivastava, Neeta Shrivastava
ETHNOPHARMACOLOGICAL RELEVANCE: Mucuna pruriens (L.) DC (MP) is an ancient Indian medicinal plant traditionally used to treat Parkinson's disease. L-Dopa (LD), precursor of dopamine is abundantly found in the seeds of MP. L-dopa is a natural inhibitor of prolactin (PRL) hormone which is required to maintain lactation in women but it's over production (hyperprolactinemia) plays critical role in advancement of breast cancer. AIM OF THE STUDY: We aim to examine the pharmacological effect of LD and MP on this hyperprolactinemia associated breast cancer and related signaling for effective management of the disease...
May 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29352722/daily-intake-of-mucuna-pruriens-in-advanced-parkinson-s-disease-a-16-week-noninferiority-randomized-crossover-pilot-study
#10
Roberto Cilia, Janeth Laguna, Erica Cassani, Emanuele Cereda, Benedetta Raspini, Michela Barichella, Gianni Pezzoli
BACKGROUND: Thousands of individuals with Parkinson's disease (PD) in low-income countries have limited access to marketed levodopa preparations. Mucuna pruriens (MP), a levodopa-containing leguminous plant growing in tropical areas, may be a sustainable alternative therapy for indigent patients. Single-dose intake of MP proved noninferior to marketed levodopa preparations. METHODS: Fourteen PD patients with motor fluctuations and dyskinesias received MP powder (obtained from roasted seeds) and marketed levodopa/carbidopa (LD/CD) in a randomized order and crossover design over a 16-week period...
April 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29330385/docking-thermodynamics-and-molecular-dynamics-md-studies-of-a-non-canonical-protease-inhibitor-mp-4-from-mucuna-pruriens
#11
Ashish Kumar, Harmeet Kaur, Abha Jain, Deepak T Nair, Dinakar M Salunke
Sequence and structural homology suggests that MP-4 protein from Mucuna pruriens belongs to Kunitz-type protease inhibitor family. However, biochemical assays showed that this protein is a poor inhibitor of trypsin. To understand the basis of observed poor inhibition, thermodynamics and molecular dynamics (MD) simulation studies on binding of MP-4 to trypsin were carried out. Molecular dynamics simulations revealed that temperature influences the spectrum of conformations adopted by the loop regions in the MP-4 structure...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/28975523/analyzing-trichomes-and-spatio-temporal-expression-of-a-cysteine-protease-gene-mucunain-in-mucuna-pruriens-l-dc
#12
Susheel Kumar Singh, Sunita Singh Dhawan
Mucuna pruriens is a well-known legume for the itching attributes of the trichome and a valuable medicinal herb that is used for the treatment of Parkinson's disease, sexual debilities, etc. Its cultivation was deprived due to its itching behavior. The wild genotype of M. pruriens have the largest trichome length (2015 ± 29 μm) compared to other genotype and mutants. The white-seeded variety of M. pruriens was found to be the most suitable for large-scale cultivation due to the small trichome size and less trichome density on the pod...
March 2018: Protoplasma
https://www.readbyqxmd.com/read/28953092/the-effects-of-mucuna-pruriens-extract-on-histopathological-and-biochemical-features-in-the-rat-model-of-ischemia
#13
Vanishri S Nayak, Nitesh Kumar, Antony S D'Souza, Sunil S Nayak, Sri P Cheruku, K Sreedhara Ranganath Pai
Stroke is considered to be one of the most important causes of death worldwide. Global ischemia causes widespread brain injury and infarctions in various regions of the brain. Oxidative stress can be considered an important factor in the development of tissue damage, which is caused because of arterial occlusion with subsequent reperfusion. Kapikacchu or Mucuna pruriens, commonly known as velvet bean, is well known for its aphrodisiac activities. It is also used in the treatment of snakebites, depressive neurosis, and Parkinson's disease...
December 13, 2017: Neuroreport
https://www.readbyqxmd.com/read/28922612/analysis-of-levodopa-content-in-commercial-mucuna-pruriens-products-using-high-performance-liquid-chromatography-with-fluorescence-detection
#14
Amala Soumyanath, Tanya Denne, Amie Hiller, Shaila Ramachandran, Lynne Shinto
OBJECTIVES: Mucuna pruriens (MP) seeds contain levodopa (up to 2% by weight) and have been used in traditional Indian medicine to treat an illness named "Kampavata," now understood to be Parkinson's disease (PD). Studies have shown MP to be beneficial, and even superior, to levodopa alone in treating PD symptoms. Commercial products containing MP are readily available from online and retail sources to patients and physicians. Products often contain extracts of MP seeds, with significantly higher levodopa content than the seeds...
February 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28898884/effects-of-mucuna-pruriens-on-free-fatty-acid-levels-and-histopathological-changes-in-the-brains-of-rats-fed-a-high-fructose-diet
#15
Bekir Akgun, Aysel Sarı, Sait Ozturk, Fatih Serhat Erol, Ibrahim Hanifi Ozercan, Ramazan Ulu
OBJECTIVE: To investigate free fatty acid levels and histopathological changes in the brain of rats fed a high fructose diet (HFrD) and to evaluate the effects of Mucuna pruriens, known to have antidiabetic activity, on these changes. MATERIALS AND METHODS: The study comprised 28 mature female Wistar rats. The rats were divided into 4 groups, each included 7 rats. Group 1: control; group 2: fed an HFrD; group 3: fed normal rat chow and M. pruriens; group 4: fed an HFrD and M...
2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28685548/immunomodulatory-potential-of-anacyclus-pyrethrum-l-and-mucuna-pruriens-l-in-male-albino-rats
#16
F Yousaf, M Shahid, M Riaz, A Atta, H Fatima
The present study was designed to investigate the immunomodulatory potential of Anacyclus pyrethrum roots and Mucuna pruriens seeds in male albino rats. The roots of A. pyrethrum and seeds of M. pruriens were extracted with methanolic solvent (70:30) and administered at dose concentrations of 50, 100 and 200 mg/Kg body weight to healthy male rats. The immune system of rats was suppressed by injecting carbon tetrachloride to animals in the toxic control group and test group animals. Cell-mediated immune response of animals was examined by performing neutrophil adhesion test and the humoral immune response was evaluated by determining serum immunoglobulin levels of the animals under study...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28685547/in-vitro-antioxidant-potential-of-selected-aphrodisiac-medicinal-plants
#17
M Riaz, M Shahid, A Jamil, M Saqib
The present study aimed to evaluate the antioxidant activity of six selected aphrodisiac medicinal plants. Useful parts of the selected medicinal plants were collected and extracted in methanolic solvent. The antioxidant activity of selected plant extract was determined through different antioxidant assays, namely DPPH radical scavenging assay and ferric reducing antioxidant assay. Moreover, antioxidant compounds, like total phenolics and total flavonoids contents, were also determined. Results showed that Mucuna pruriens seed extract displayed high contents of phenolic compounds with total phenolic content of 683...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28679598/-mucuna-pruriens-in-parkinson-disease-a-double-blind-randomized-controlled-crossover-study
#18
RANDOMIZED CONTROLLED TRIAL
Roberto Cilia, Janeth Laguna, Erica Cassani, Emanuele Cereda, Nicolò G Pozzi, Ioannis U Isaias, Manuela Contin, Michela Barichella, Gianni Pezzoli
OBJECTIVE: To investigate whether Mucuna pruriens (MP), a levodopa-containing leguminous plant growing in all tropical areas worldwide, may be used as alternative source of levodopa for indigent individuals with Parkinson disease (PD) who cannot afford long-term therapy with marketed levodopa preparations. METHODS: We investigated efficacy and safety of single-dose intake of MP powder from roasted seeds obtained without any pharmacologic processing. Eighteen patients with advanced PD received the following treatments, whose sequence was randomized: (1) dispersible levodopa at 3...
August 1, 2017: Neurology
https://www.readbyqxmd.com/read/28642128/immunomodulation-of-parkinson-s-disease-using-mucuna-pruriens-mp
#19
REVIEW
Sachchida Nand Rai, Hareram Birla, Walia Zahra, Saumitra Sen Singh, Surya Pratap Singh
Immune control is associated with nigrostriatal neuroprotection for Parkinson's disease (PD); though its direct cause and effect relationships have not yet been realized and modulating the immune system for therapeutic gain has been openly discussed. While the pathobiology of PD remains in study, neuroinflammation is thought to speed nigrostriatal degeneration. The neuroinflammatory cascade associated with PD begins with aggregation of misfolded or post-translationally modified α-synuclein (α-syn). Such aggregation results in neuronal cell death and the presence of chronically activated glia (microglia and astroglia), leading to the production of proinflammatory cytokines like tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), IL-6, and enzymes such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and cyclooxygenase-2 (COX-2)...
November 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28640753/mechanism-of-antihypertensive-effect-of-mucuna-pruriens-l-seed-extract-and-its-isolated-compounds
#20
Mohammad Yaseen Khan, Vimal Kumar
Background In the search of safe and effective lead molecules from natural sources, Mucuna pruriens (MP) L. (Fabaceae) seeds were utilized for exploring the antihypertensive potential. Traditionally, it is used as diuretic and hypotensive. Methods Bioassay-guided fractions were utilized for the isolation of active compounds by column chromatography. IC50 value, enzyme kinetics and inhibition mechanism were determined. In vivo time and dose-dependent hypotensive study followed by changes in mean arterial pressure (MAP) induced by angiotensin I (3 nmol/kg), angiotensin II (3 nmol/kg), and bradykinin (10 nmol/kg) in anesthetized rats was done...
June 21, 2017: Journal of Complementary & Integrative Medicine
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