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https://www.readbyqxmd.com/read/29773998/larger-gray-matter-volume-in-the-basal-ganglia-of-heavy-cannabis-users-detected-by-voxel-based-morphometry-and-subcortical-volumetric-analysis
#1
Ana Moreno-Alcázar, Begoña Gonzalvo, Erick J Canales-Rodríguez, Laura Blanco, Diana Bachiller, Anna Romaguera, Gemma C Monté-Rubio, Carlos Roncero, Peter J McKenna, Edith Pomarol-Clotet
Background: Structural imaging studies of cannabis users have found evidence of both cortical and subcortical volume reductions, especially in cannabinoid receptor-rich regions such as the hippocampus and amygdala. However, the findings have not been consistent. In the present study, we examined a sample of adult heavy cannabis users without other substance abuse to determine whether long-term use is associated with brain structural changes, especially in the subcortical regions. Method: We compared the gray matter volume of 14 long-term, heavy cannabis users with non-using controls...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29755611/morphological-biomarker-differentiating-mci-converters-from-nonconverters-longitudinal-evidence-based-on-hemispheric-asymmetry
#2
Xiaojing Long, Chunxiang Jiang, Lijuan Zhang
Identifying subjects with mild cognitive impairment (MCI) who may probably progress to Alzheimer's disease (AD) is important for better understanding the disease mechanisms and facilitating early treatments. In addition to the direct volumetric and thickness measurement based on high-resolution magnetic resonance imaging (MRI), hemispheric asymmetry could be a potential index to detect morphological variations in MCI patients with a high risk of conversion to AD. The present study collected a set of longitudinal MRI data from 53 MCI converters and nonconverters and investigated the asymmetry differences between groups...
2018: Behavioural Neurology
https://www.readbyqxmd.com/read/29754151/a-voxel-based-magnetic-resonance-imaging-morphometric-study-of-cerebral-and-cerebellar-gray-matter-in-patients-under-65-years-with-essential-tremor
#3
Hongmei Cao, Rong Wang, Xue Luo, Xianjun Li, Mark Hallett, Johanna Thompson-Westra, Jian Yang, Qiumin Qu, Xiaobo Yang
BACKGROUND The aim of this study was to compare the morphological changes in cerebral and cerebellar gray matter in patients with essential tremor under 60-years-of-age, with age-matched and gender-matched normal healthy volunteer control subjects, using functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM) analysis. MATERIAL AND METHODS A retrospective, controlled, comparative clinical study included 17 patients with essential tremor, <60 years-of-age, and 17 age-matched and gender-matched healthy volunteer control subjects, recruited between June 2010-July 2012...
May 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29744798/the-effect-of-future-time-perspective-on-procrastination-the-role-of-parahippocampal-gyrus-and-ventromedial-prefrontal-cortex
#4
Peiwei Liu, Tingyong Feng
Procrastination is an almost universal affliction, which occurs across culture and brings serious consequences across multiple fields, such as finance, health and education. Previous research has showed procrastination can be influenced by future time perspective (FTP). However, little is known about the neural basis underlying the impact of FTP on procrastination. To address this question, we used voxel-based morphometry (VBM) based on brain structure. In line with previous findings, the behavioral result indicated that FTP inventory scores were significantly negatively correlated with procrastination inventory scores (r = -0...
May 9, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29740296/distinguishing-adolescents-with-conduct-disorder-from-typically-developing-youngsters-based-on-pattern-classification-of-brain-structural-mri
#5
Jianing Zhang, Weixiang Liu, Jing Zhang, Qiong Wu, Yidian Gao, Yali Jiang, Junling Gao, Shuqiao Yao, Bingsheng Huang
Background: Conduct disorder (CD) is a mental disorder diagnosed in childhood or adolescence that presents antisocial behaviors, and is associated with structural alterations in brain. However, whether these structural alterations can distinguish CD from healthy controls (HCs) remains unknown. Here, we quantified these structural differences and explored the classification ability of these quantitative features based on machine learning (ML). Materials and Methods: High-resolution 3D structural magnetic resonance imaging (sMRI) was acquired from 60 CD subjects and 60 age-matched HCs...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29727807/voxel-based-morphometry-analysis-of-structural-brain-scans-in-skin-picking-disorder
#6
Anne Schienle, Jonas Potthoff, Albert Wabnegger
BACKGROUND: Skin-picking disorder (SPD) is characterized by the excessive and repetitive manipulation of one's own skin resulting in tissue damage and impaired social functioning. There are only a few studies with small sample sizes that examined possible brain abnormalities in SPD, which is classified as a syndrome related to obsessive-compulsive disorders (OCD). METHOD: The current voxel-based morphometry (VBM) study compared data from 35 SPD patients and 35 control participants including both genders (mean age = 35 years, SD = 15)...
April 26, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29727625/beyond-volume-a-surface-based-approach-to-bilingualism-induced-grey-matter-changes
#7
Sini Hämäläinen, Juho Joutsa, Aleksi J Sihvonen, Alina Leminen, Minna Lehtonen
Bilingualism is a sustained experience associated with structural changes in cortical grey matter (GM) morphology. Apart from a few studies, a dominant method used to assess bilingualism-induced GM changes has been the voxel-based morphometry (VBM) analysis. While VBM is sensitive to GM volume/density differences in general, it cannot be used to identify whether the observed difference is due to relative changes in, e.g., cortical thickness, area or folding, as it uses a single combined measure of them all...
May 1, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29717540/brainmap-vbm-an-environment-for-structural-meta-analysis
#8
Thomas J Vanasse, P Mickle Fox, Daniel S Barron, Michaela Robertson, Simon B Eickhoff, Jack L Lancaster, Peter T Fox
The BrainMap database is a community resource that curates peer-reviewed, coordinate-based human neuroimaging literature. By pairing the results of neuroimaging studies with their relevant meta-data, BrainMap facilitates coordinate-based meta-analysis (CBMA) of the neuroimaging literature en masse or at the level of experimental paradigm, clinical disease, or anatomic location. Initially dedicated to the functional, task-activation literature, BrainMap is now expanding to include voxel-based morphometry (VBM) studies in a separate sector, titled: BrainMap VBM...
May 2, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29704671/apathy-in-alzheimer-s-disease-and-frontotemporal-dementia-distinct-clinical-profiles-and-neural-correlates
#9
Fiona Kumfor, Alice Zhen, John R Hodges, Olivier Piguet, Muireann Irish
OBJECTIVE: Apathy is the most prevalent and disabling non-cognitive symptom of dementia and affects 90% of patients across the disease course. Despite its pervasiveness, how apathy manifests across dementia syndromes and the neurobiological mechanisms driving these symptoms are poorly understood. Here, we applied the multidimensional ABC model of apathy, which recognizes Affective, Behavioural and Cognitive apathy, in Alzheimer's disease (AD) and behavioural-variant frontotemporal dementia (bvFTD)...
March 29, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29703156/functional-outcomes-in-hirschsprung-disease-patients-after-transabdominal-soave-and-duhamel-procedures
#10
Amira Widyasari, Winona Alda Pravitasari, Andi Dwihantoro, Gunadi
BACKGROUND: Several pull-through procedures have been described for Hirschsprung disease (HSCR) with varying functional outcomes. The voluntary bowel movement (VBM) and the absence of soiling or constipation after pull-through remain the most important markers of good outcome. We aimed to compare the functional outcomes in HSCR patients following Soave and Duhamel procedures. METHODS: Krickenbeck classification was utilized to determine VBM, soiling and constipation for patients who underwent Soave and Duhamel pull-through at Dr...
April 27, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29696245/longitudinal-genotype-phenotype-association-study-via-temporal-structure-auto-learning-predictive-model
#11
Xiaoqian Wang, Jingwen Yan, Xiaohui Yao, Sungeun Kim, Kwangsik Nho, Shannon L Risacher, Andrew J Saykin, Li Shen, Heng Huang
With rapid progress in high-throughput genotyping and neuroimaging, imaging genetics has gained significant attention in the research of complex brain disorders, such as Alzheimer's Disease (AD). The genotype-phenotype association study using imaging genetic data has the potential to reveal genetic basis and biological mechanism of brain structure and function. AD is a progressive neurodegenerative disease, thus, it is crucial to look into the relations between SNPs and longitudinal variations of neuroimaging phenotypes...
May 2017: Research in Computational Molecular Biology: ... Annual International Conference, RECOMB ...: Proceedings
https://www.readbyqxmd.com/read/29695908/the-functional-and-structural-characteristics-of-the-emotion-network-in-alexithymia
#12
Dai Han, Mei Li, Minjun Mei, Xiaofei Sun
Background: Alexithymia is a multifaceted personality trait characterized by emotional dysfunction. Methods: In this study, the functional and structural features of the emotion network in alexithymia were investigated using resting-state functional MRI (rsfMRI), voxel-based morphometry (VBM), functional connectivity (FC) analysis, and diffusion tensor imaging (DTI). Alexithymic and non-alexithymic students were recruited from the local university. The intrinsic neural activity and gray matter density of the brain regions in the emotion network were measured using rsfMRI and VBM; the FC and structural connectivity of the brain regions in the emotion network were measured using FC analysis and DTI...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29691468/large-scale-brain-network-associated-with-creative-insight-combined-voxel-based-morphometry-and-resting-state-functional-connectivity-analyses
#13
Takeshi Ogawa, Takatsugu Aihara, Takeaki Shimokawa, Okito Yamashita
Creative insight occurs with an "Aha!" experience when solving a difficult problem. Here, we investigated large-scale networks associated with insight problem solving. We recruited 232 healthy participants aged 21-69 years old. Participants completed a magnetic resonance imaging study (MRI; structural imaging and a 10 min resting-state functional MRI) and an insight test battery (ITB) consisting of written questionnaires (matchstick arithmetic task, remote associates test, and insight problem solving task)...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29681925/neuroanatomical-alterations-in-patients-with-early-stage-of-unilateral-pulsatile-tinnitus-a-voxel-based-morphometry-study
#14
Yawen Liu, Han Lv, Pengfei Zhao, Zhaohui Liu, Wenjing Chen, Shusheng Gong, Zhenchang Wang, Jian-Ming Zhu
During the past several years, the rapid development of neuroimaging techniques has contributed greatly in the noninvasive imaging studies of tinnitus. The aim of the present study was to explore the brain anatomical alterations in patients with right-sided unilateral pulsatile tinnitus (PT) in the early stage of PT symptom using voxel-based morphometry (VBM) analysis. Twenty-four patients with right-sided pulsatile tinnitus and 24 age- and gender-matched normal controls were recruited to this study. Structural image data preprocessing was performed using VBM8 toolbox...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29673867/structural-differences-in-hippocampal-and-entorhinal-gray-matter-volume-support-individual-differences-in-first-person-navigational-ability
#15
Katherine R Sherrill, Elizabeth R Chrastil, Irem Aselcioglu, Michael E Hasselmo, Chantal E Stern
The ability to update position and orientation to reach a goal is crucial to spatial navigation and individuals vary considerably in this ability. The current structural MRI study used voxel-based morphometry (VBM) analysis to relate individual differences in human brain morphology to performance in an active navigation task that relied on updating position and orientation in a landmark-free environment. Goal-directed navigation took place from either a first person perspective, similar to a person walking through the landmark-free environment, or Survey perspective, a bird's eye view...
April 16, 2018: Neuroscience
https://www.readbyqxmd.com/read/29672906/do-brain-structural-abnormalities-differentiate-separate-forms-of-urgency-urinary-incontinence
#16
Becky D Clarkson, Derek Griffiths, Neil M Resnick
AIMS: Urgency urinary incontinence (UUI) is a major problem for seniors. The underlying mechanisms of disease and therapy are unknown. We sought structural brain abnormalities that might underlie the functional differences previously observed by functional Magnetic Resonance Imaging in UUI patients versus controls, or among UUI responders versus non-responders to therapy-and thereby reveal potential disease mechanisms and therapeutic targets. METHODS: Secondary study of a trial of biofeedback-assisted pelvic floor muscle training (BFB) in 60 women (>60 yrs) with UUI, plus 11 age-matched continent controls...
April 19, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29667810/highly-stable-thin-film-transistors-based-on-indium-oxynitride-semiconductor
#17
Hyoung-Do Kim, Jong Heon Kim, Kyung Park, Yun Chang Park, Sunkook Kim, Yong Joo Kim, Jozeph Park, Hyun-Suk Kim
In this study, the properties of indium oxynitride (InON) semiconductor films grown by reactive radio frequency sputtering were examined both experimentally and theoretically. Also, thin film transistors (TFTs) incorporating InON as the active layer were evaluated for the first time. It is found that InON films exhibit high stability upon prolonged exposure to air, and the corresponding TFTs are more stable when subjected to negative bias illumination stress (NBIS), compared to devices based on indium oxide (In2O3) or zinc oxynitride (ZnON) semiconductors...
April 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29656960/circulating-vascular-basement-membrane-fragments-are-associated-with-the-diameter-of-the-abdominal-aorta-and-their-expression-pattern-is-altered-in-aaa-tissue
#18
Mari Holsti, Anders Wanhainen, Christina Lundin, Martin Björck, Gustaf Tegler, Johan Svensson, Malin Sund
OBJECTIVE: Abdominal aortic aneurysm (AAA) is characterised by enhanced proteolytic activity, and extracellular matrix (ECM) remodelling in the vascular wall. Type IV and XVIII collagen/endostatin are structural proteins in vascular basement membrane (VBM), a specialised ECM structure. Here the association between plasma levels of these collagens with the aortic diameter and expansion rate is studied, and their expression in aortic tissue characterised. METHODS: This was a retrospective population based cohort study...
April 12, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29627589/gaussian-process-uncertainty-in-age-estimation-as-a-measure-of-brain-abnormality
#19
Benjamin Gutierrez Becker, Tassilo Klein, Christian Wachinger
Multivariate regression models for age estimation are a powerful tool for assessing abnormal brain morphology associated to neuropathology. Age prediction models are built on cohorts of healthy subjects and are built to reflect normal aging patterns. The application of these multivariate models to diseased subjects usually results in high prediction errors, under the hypothesis that neuropathology presents a similar degenerative pattern as that of accelerated aging. In this work, we propose an alternative to the idea that pathology follows a similar trajectory than normal aging...
April 5, 2018: NeuroImage
https://www.readbyqxmd.com/read/29626609/homozygous-lamc3-mutation-links-to-structural-and-functional-changes-in-visual-attention-networks
#20
REVIEW
Buse M Urgen, Yasemin Topac, F Seyhun Ustun, Pinar Demirayak, Kader K Oguz, Tulay Kansu, Serap Saygi, Tayfun Ozcelik, Huseyin Boyaci, Katja Doerschner
The occipital lobe contains a substantial part of the neural machinery involved in visual perception. Mutations in the LAMC3 gene have recently been shown to cause complex bilateral occipital cortical gyration abnormalities. However, to what extent these structural changes impact visual behavior is not known. We recorded responses for two screening test batteries targeting visual function (Leuven - Perceptual Organization Screening Test, Cortical Vision Screening Test) and measured eye fixation performance in a visual attention experiment from a patient with homozygous LAMC3 gene mutation...
April 4, 2018: NeuroImage
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