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Matthew J Maurer, Jean-Philippe Jais, Hervé Ghesquières, Thomas E Witzig, Fangxin Hong, Corinne Haioun, Carrie A Thompson, Catherine Thieblemont, Ivana N Micallef, Luis F Porrata, Vincent Ribrag, Gregorz S Nowakowski, Olivier Casasnovas, Serge Bologna, Franck Morschhauser, Vicki A Morrison, Bruce A Peterson, William R Macon, Christiane Copie-Bergman, Andrew L Feldman, Sergei I Syrbu, Paul J Kurtin, Randy D Gascoyne, Hailun Li, Cristine Allmer, Brad S Kahl, Stephen M Ansell, Susan L Slager, Brian K Link, Gilles Salles, Thomas M Habermann, Hervé Tilly, James R Cerhan
We recently defined event-free survival at 24 months (EFS24) as a clinically relevant outcome for patients with DLBCL. Patients who fail EFS24 have very poor overall survival, while those who achieve EFS24 have a subsequent overall survival equivalent to that of the age- and sex-matched general population. Here, we develop and validate a clinical risk calculator (IPI24) for EFS24. Model building was performed on a discovery dataset of 1,348 patients with DLBCL and treated with anthracycline-based immunochemotherapy...
February 2016: American Journal of Hematology
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