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https://www.readbyqxmd.com/read/28319320/the-endochondral-bone-protein-chm1-sustains-an-undifferentiated-invasive-phenotype-promoting-lung-metastasis-in-ewing-sarcoma
#1
Kristina von Heyking, Julia Calzada-Wack, Stefanie Göllner, Frauke Neff, Oxana Schmidt, Tim Hensel, David Schirmer, Annette Fasan, Irene Esposito, Carsten Müller-Tidow, Poul H Sorensen, Stefan Burdach, Günther H S Richter
Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by EWS-ETS translocations and early metastasis to lung and bone. In this study, we investigated the role of the BRICHOS chaperone domain-containing endochondral bone protein chondromodulin I (CHM1) in ES pathogenesis. CHM1 is significantly over-expressed in ES, and chromosome immunoprecipitation (ChIP) data demonstrate CHM1 to be directly bound by an EWS-ETS translocation, EWS-FLI1. Using RNA interference we observed that CHM1 promoted chondrogenic differentiation capacity of ES cells but decreased the expression of osteolytic genes such as HIF1A, IL6, JAG1 and VEGF...
March 20, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28303642/efficacy-of-collagen-matrix-seal-and-collagen-sponge-on-ridge-preservation-in-combination-with-bone-allograft-a-randomized-controlled-clinical-trial
#2
Zuhair S Natto, Andreas Parashis, Bjorn Steffensen, Rumpa Ganguly, Matthew D Finkelman, Y Natalie Jeong
AIM: To test whether the use of collagen matrix seal (CMS) results in similar hard and soft tissue remodeling to that with collagen sponge (CS) used as barriers 4 months following alveolar ridge preservation (ARP), in combination with freeze-dried bone allograft (FDBA). MATERIALS AND METHODS: Twenty-eight patients were randomly assigned to the two groups. Clinical and radiographic measurements were recorded with the same stent at baseline and 4 months for standardization...
March 16, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28303476/a-review-of-clinical-cases-of-infection-with-photorhabdus-asymbiotica
#3
John G Gerrard, Robert P Stevens
The three recognised Photorhabdus species are bioluminescent Gram-negative bacilli of the family Enterobacteriaceae. They are all pathogenic to insects and form a symbiotic relationship with nematodes of the genus Heterorhabditis. P. luminescens and P. temperata are both harmless to humans whilst P. asymbiotica, on the other hand, is a human pathogen that is a symbiont of the newly described nematode vector, Heterorhabditis gerrardi. In this chapter, we review the epidemiological and clinical features of eighteen human cases of P...
March 17, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28299781/architectural-differences-in-the-anterior-and-middle-compartments-of-the-pelvic-floor-of-young-adult-and-postmenopausal-females
#4
Yi Wu, Noshir F Dabhoiwala, Jaco Hagoort, Li-Wen Tan, Shao-Xiang Zhang, Wouter H Lamers
The pelvic floor guards the passage of the pelvic organs to the exterior. The near-epidemic prevalence of incontinence in women continues to generate interest in the functional anatomy of the pelvic floor. However, due to its complex architecture and poor accessibility, the classical 'dissectional' approach has been unable to come up with a satisfactory description, so that many aspects of its anatomy continue to raise debate. For this reason, we opted for a 'sectional' approach, using the Chinese Visible Human project (four females, 21-35 years) and the Visible Human Project (USA; one female, 59 years) datasets to investigate age-related changes in the architecture of the anterior and middle compartments of the pelvic floor...
March 16, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28298828/changes-of-the-peri-implant-soft-tissue-thickness-after-grafting-with-a-collagen-matrix
#5
Gregory-George Zafiropoulos, Giorgio Deli, Oliver Hoffmann, Gordon John
BACKGROUND: The aim of this study was to determine the treatment outcome of the use of a porcine monolayer collagen matrix (mCM) to increase soft-tissue volume as a part of implant site development. MATERIALS AND METHODS: Implants were placed in single sites in 27 patients. In the test group, mCM was used for soft-tissue augmentation. No graft was placed in the control group. Soft-tissue thickness (STTh) was measured at the time of surgery (T0) and 6 months postoperatively (T1) at two sites (STTh 1, 1 mm below the gingival margin; STTh 2, 3 mm below the mucogingival margin)...
July 2016: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/28297893/direct-link-between-boson-peak-modes-and-dielectric-%C3%AE-relaxation-in-glasses
#6
Bingyu Cui, Rico Milkus, Alessio Zaccone
We compute the dielectric response of glasses starting from a microscopic system-bath Hamiltonian of the Zwanzig-Caldeira-Leggett type and using an ansatz from kinetic theory for the memory function in the resulting generalized Langevin equation. The resulting framework requires the knowledge of the vibrational density of states (DOS) as input, which we take from numerical evaluation of a marginally stable harmonic disordered lattice, featuring a strong boson peak (excess of soft modes over Debye ∼ω_{p}^{2} law)...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28296814/pedicle-screw-safety-how-much-anterior-breach-is-safe-a-cadaveric-and-ct-based-study
#7
Vishal Sarwahi, Monica Payares, Rachel Gecelter, Stephen Wendolowski, Kathleen Maguire, Dan Wang, Beverly Thornhill, Terry Amaral
STUDY DESIGN: Clinical retrospective chart review and basic science study OBJECTIVES.: To determine the safety limits of an anterior/anterorolateral misplaced pedicle screw on CT scan in spinal deformity. SUMMARY OF BACKGROUND DATA: While the limits of medial breaches (<4 mm) are known, the safe limits for anterior/anterolateral breaches in spine deformity are not yet defined. METHODS: This study had two parts. In part I, post-operative CT scans of 165 patients operated on for spine deformity were reviewed for screw misplacement (2800 screws)...
March 14, 2017: Spine
https://www.readbyqxmd.com/read/28295994/transcriptome-analysis-of-the-dickeya-dadantii-pecs-regulon-during-early-stages-of-interaction-with-arabidopsis-thaliana
#8
Jacques Pédron, Emilie Chapelle, Benoît Alunni, Frédérique Van Gijsegem
PecS is one of the major global regulators controlling virulence of Dickeya dadantii, a broad host range phytopathogenic bacterium causing soft rot on several plant families. To define the PecS regulon during plant colonisation, we analysed the global transcriptome profiles in wild type and pecS mutant strains during early colonization of the leaf surfaces and in leaf tissue just before the onset of symptoms and found that the PecS regulon consists of more than 600 genes. About one half of these genes are down-regulated in the pecS mutant, therefore PecS has both positive and negative regulatory roles that may be direct or indirect...
March 15, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/28293496/closure-of-a-large-thoracolumbar-myelomeningocele-using-a-modified-bilateral-keystone-flap
#9
Hytham Jamjoom, Hatem Alnoman, Yasser Almadani
The keystone flap, an emerging reconstructive option that can be used in many parts of the body, is gaining popularity among reconstructive surgeons. These reliable and versatile flaps can be used for large myelomeningocele closure. A modified bilateral keystone flap was used to achieve tension-free closure of a large thoracolumbar myelomeningocele associated with severe kyphosis in a newborn girl. The flap was modified by undermining in the subfascial plane in the medial aspect of the middle third. This undermining was performed to facilitate flap movement while preserving random musculocutaneous perforators captured within the island of tissues...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28291905/long-term-results-of-therapy-with-sunitinib-in-metastatic-alveolar-soft-part-sarcoma
#10
Paulina Jagodzińska-Mucha, Tomasz Świtaj, Katarzyna Kozak, Hanna Koseła-Paterczyk, Anna Klimczak, Iwona Ługowska, Pawel Rogala, Michał Wągrodzki, Sławomir Falkowski, Piotr Rutkowski
BACKGROUND: Alveolar soft part sarcoma (ASPS) is a rare, highly vascularized soft tissue sarcoma characterized by a high frequency of metastatic disease and resistance to classical chemotherapy. The purpose of our analysis was to assess long-term sunitinib activity in the treatment of metastatic ASPS. PATIENTS AND METHODS: Between 2009 and 2015, 15 patients were diagnosed with metastatic ASPS and received therapy with sunitinib at initial continuous daily dosing of 37...
March 8, 2017: Tumori
https://www.readbyqxmd.com/read/28291497/variation-in-postinjury-antibiotic-prophylaxis-patterns-over-five-years-in-a-combat-zone
#11
Bradley A Lloyd, Clinton K Murray, William Bradley, Faraz Shaikh, Deepak Aggarwal, M Leigh Carson, David R Tribble
In 2008, a clinical practice guideline (CPG) was developed for the prevention of infections among combat casualties and was later revised in 2011. We evaluated utilization of antimicrobials within 48 hours following injury in the combat zone over a 5-year period (June 2009 through May 2014) with regard to number of regimens, type of antimicrobial, and adherence to the 2011 CPG. The study population consisted of 5,196 wounded military personnel. Open fractures and skin and soft-tissue injuries were the most frequent injuries...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28291020/cell-adhesion-pattern-created-by-oste-polymers
#12
Wenjia Liu, Yiyang Li, Xianting Ding
Engineering surfaces with functional polymers is a crucial issue in the field of micro/nanofabrication and cell-material interface studies. For many applications of surface patterning, it does not need cells to attach on the whole surface. Herein, we introduce a novel polymer fabrication protocol of off-stoichiometry thiol-ene (OSTE) polymers to create heterogeneity on the surface by utilizing 3D printing and soft-lithography. By choosing two OSTE polymers with different functional groups, we create a pattern where only parts of the surface can facilitate cell adhesion...
March 14, 2017: Biofabrication
https://www.readbyqxmd.com/read/28290318/genotype-evaluation-of-cowpea-seeds-vigna-unguiculata-using-1-h-qnmr-combined-with-exploratory-tools-and-solid-state-nmr
#13
Elenilson G Alves Filho, Lorena M A Silva, Elizita M Teofilo, Flemming H Larsen, Edy S de Brito
The ultimate aim of this study was to apply a non-targeted chemometric analysis (principal component analysis and hierarchical clustering analysis using the heat map approach) of NMR data to investigate the variability of organic compounds in nine genotype cowpea seeds, without any complex pre-treatment. In general, both exploratory tools show that Tvu 233, CE-584, and Setentão genotypes presented higher amount mainly of raffinose and Tvu 382 presented the highest content of choline and least content of raffinose...
January 2017: Food Research International
https://www.readbyqxmd.com/read/28287938/soft-tissue-sarcomas-of-the-abdomen-and-pelvis-radiologic-pathologic-features-part-1-common-sarcomas-from-the-radiologic-pathology-archives
#14
Angela D Levy, Maria A Manning, Waddah B Al-Refaie, Markku M Miettinen
Soft-tissue sarcomas are a diverse group of rare mesenchymal malignancies that can arise at any location in the body and affect all age groups. These sarcomas are most common in the extremities, trunk wall, retroperitoneum, and head and neck. In the adult population, soft-tissue sarcomas arising in the abdomen and pelvis are often large masses at the time of diagnosis because they are usually clinically silent or cause vague or mild symptoms until they invade or compress vital organs. In contrast, soft-tissue sarcomas arising from the abdominal wall come to clinical attention earlier in the course of disease because they cause a palpable mass, abdominal wall deformity, or pain that is more clinically apparent...
March 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28287481/cellular-midpalatal-suture-changes-after-rapid-maxillary-expansion-in-growing-subjects-a-case-report
#15
Alberto Caprioglio, Rosamaria Fastuca, Piero Antonio Zecca, Matteo Beretta, Carlo Mangano, Adriano Piattelli, Aldo Macchi, Giovanna Iezzi
The present case report aimed to investigate immediate histologic changes in midpalatal suture in humans following rapid maxillary expansion compared to control. Three patients (mean age 8.3 +/- 0.9 years) were enrolled in the case report and underwent midpalatal suture biopsy. Two patients underwent treatment before biopsy. The third patient did not show transversal maxillary deficiency and was enrolled as a control. Biopsy samples of midpalatal suture at 7 (subject 1) and 30 days (subject 2) after maxillary expansion as well as of one control (subject 3) were collected and processed for histology...
March 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28286348/growth-and-remodeling-of-load-bearing-biological-soft-tissues
#16
C J Cyron, J D Humphrey
The past two decades reveal a growing role of continuum biomechanics in understanding homeostasis, adaptation, and disease progression in soft tissues. In this paper, we briefly review the two primary theoretical approaches for describing mechano-regulated soft tissue growth and remodeling on the continuum level as well as hybrid approaches that attempt to combine the advantages of these two approaches while avoiding their disadvantages. We also discuss emerging concepts, including that of mechanobiological stability...
February 2017: Meccanica
https://www.readbyqxmd.com/read/28285037/a-targeted-approach-to-ligament-balancing-using-kinetic-sensors
#17
Kenneth A Gustke, Gregory J Golladay, Martin W Roche, Leah C Elson, Christopher R Anderson
BACKGROUND: Currently, soft-tissue imbalance contributes to several of the foremost reasons for revision following primary TKA, including instability, stiffness, and aseptic loosening. In order to decrease the incidence of soft-tissue imbalance, intraoperative sensors were developed to provide real-time, quantitative load data within the knee. This study examines the intraoperative data of a group of multicenter patients to determine how targeted ligament releases affect intra-articular loading, and to understand which types of releases are necessary to achieve quantified ligament balance...
February 16, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28272664/desmoplastic-fibroblastoma-in-maxillary-alveolar-bone-mimicking-an-odontogenic-lesion-a-novel-case-report-with-review-of-literature
#18
Zohreh Jaafari-Ashkavandi, Mehdi Yasamin Shirazi, Sepideh Assar
Desmoplastic fibroblastoma (Collagenous fibroma) is a rare benign soft tissue tumor that disseminates widely and can be intramuscular or subcutaneously. There are seven reported cases in the oral cavity so far. We reported a novel case of collagenous fibroma that has been found in the anterior part of maxilla in a 58-year-old woman as an intraosseous radiolucent lesion that has been discovered during routine radiography. Histopathologically, spindle and stellate-shaped fibroblasts in a collagen-rich stroma as well as binucleated and multinucleated fibroblasts with prominent nucleoli were seen...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28272248/awareness-of-food-nutritive-value-and-eating-practices-among-nigerian-bank-workers-implications-for-nutritional-counseling-and-education
#19
Ngozi M Eze, Felicia O Maduabum, Nkechi G Onyeke, Ngozi J Anyaegunam, Chinwe A Ayogu, Bibian Amaka Ezeanwu, Chiedu Eseadi
Adequate nutrition is an important aspect of a healthy lifestyle for all individuals, including bank staff. The objective of this study was to investigate the awareness of food nutritive value and eating practices among bank workers in Lagos State, Nigeria.The study adopted a cross-sectional descriptive survey design. A purposive sample of 250 bank workers took part in the study. Means and Student t tests were employed for data analysis.Results showed that bank workers were aware of the nutritive value of foods, and that eating practices commonly adopted included skipping breakfast, eating breakfast at work, buying food at work from the bank canteen, eating in between meals, buying snacks as lunch, and consuming soft drinks daily, among others...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28271898/exploring-oxygen-activity-in-the-high-energy-p2-type-na0-78ni0-23mn0-69o2-cathode-material-for-na-ion-batteries
#20
Chuze Ma, Judith Alvarado, Jing Xu, Raphaële J Clément, Moses Kodur, Wei Tong, Clare P Grey, Ying Shirley Meng
Large-scale electric energy storage is fundamental to the use of renewable energy. Recently, research and development efforts on room-temperature sodium-ion batteries (NIBs) have been revitalized, as NIBs are considered promising, low-cost alternatives to the current Li-ion battery technology for large-scale applications. Herein, we introduce a novel layered oxide cathode material, Na0.78Ni0.23Mn0.69O2. This new compound provides a high reversible capacity of 138 mAh g-1 and an average potential of 3.25 V vs...
March 8, 2017: Journal of the American Chemical Society
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