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https://www.readbyqxmd.com/read/28813844/soft-stop-knee-brace-for-rehabilitation-from-ligament-injuries-design-and-pilot-trial
#1
James R J Greenfield, Haram Francis Hwang, Claire Davies, Andrew J McDaid
Ligaments within the human knee are commonly torn or injured as a result of sports that involve sharp direction changes, pivoting and landing. For this reason, athletes are often side-lined from their respective sports for up to 18 months after injury to rehabilitate. As part of the rehabilitation process, knee braces are often prescribed in an attempt to decrease the recovery period of the injured individual by restraining and minimizing the motion at the knee. However, the true efficacy of knee bracing is yet to be fully evaluated as studies show mixed results to whether braces actually decrease the rehabilitation period for patients...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28812751/hydrogen-bonded-rosettes-comprising-%C3%AF-conjugated-systems-as-building-blocks-for-functional-one-dimensional-assemblies
#2
Bimalendu Adhikari, Xu Lin, Mitsuaki Yamauchi, Hayato Ouchi, Keisuke Aratsu, Shiki Yagai
Hydrogen-bonded supermacrocycles (rosettes) are attractive disk-shaped noncovalent synthons for extended functional columnar nanoassemblies. They can serve not only as noncovalent monomer units for supramolecular polymers and discrete oligomers in a dilute solution but also as constituent entities for soft matters such as gels and lyotropic/thermotropic liquid crystals. However, what are the merits of using supramolecular rosettes instead of using expanded π-conjugated covalent molecules? This review covers the self-assembly of photochemically and electrochemically active π-conjugated molecules through the formation of supramolecular rosettes via directional complementary multiple hydrogen-bonding interactions...
August 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28809494/on-protein-assembly-and-building-blocks-beyond-the-limits-of-the-lego-bricks-metaphor
#3
Yaakov Levy
Proteins, similarly to other biomolecules, have a modular and hierarchical structure. Various building blocks serve to construct proteins of high structural complexity and diverse functionality. In multi-domain proteins, for example, domains are fused to each other in different combinations to achieve different functions. Although the LEGO bricks metaphor is justified as a means of simplifying the complexity of 3-dimensional protein structures, several fundamental properties (such as allostery or the induced-fit mechanism) make deviation from it necessary to respect the plasticity, softness, and cross-talks that are essential to protein function...
August 15, 2017: Biochemistry
https://www.readbyqxmd.com/read/28802096/comparison-of-cleaning-methods-for-delicate-insect-specimens-for-scanning-electron-microscopy
#4
Katharina Schneeberg, René Bauernfeind, Hans Pohl
The objective of the present study was to compare cleaning methods for delicate insect specimens for investigations with scanning electron microscopy (SEM). As typical specimens we used aquatic larvae of mosquitoes, springtails, larvae of mayflies and caterpillars because they are very fragile and large parts of their body consist of soft tissue. Additionally their cuticle is very often covered with dirt, soil particles or other materials. Cleaning with ultrasonic sound, as the most common cleaning method used for SEM, will destroy fragile insects...
August 12, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28801570/the-buckling-instability-of-aggregating-red-blood-cells
#5
Daniel Flormann, Othmane Aouane, Lars Kaestner, Christian Ruloff, Chaouqi Misbah, Thomas Podgorski, Christian Wagner
Plasma proteins such as fibrinogen induce the aggregation of red blood cells (RBC) into rouleaux, which are responsible for the pronounced shear thinning behavior of blood, control the erythrocyte sedimentation rate (ESR) - a common hematological test - and are involved in many situations of physiological relevance such as structuration of blood in the microcirculation or clot formation in pathological situations. Confocal microscopy is used to characterize the shape of RBCs within rouleaux at equilibrium as a function of macromolecular concentration, revealing the diversity of contact zone morphology...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800764/lrp-a-global-regulator-regulates-the-virulence-of-vibrio-vulnificus
#6
Yu-Chi Ho, Feng-Ru Hung, Chao-Hui Weng, Wei-Ting Li, Tzu-Hung Chuang, Tsung-Lin Liu, Ching-Yuan Lin, Chien-Jung Lo, Chun-Liang Chen, Jen-Wei Chen, Masayuki Hashimoto, Lien-I Hor
BACKGROUND: An attenuated mutant (designated NY303) of Vibrio vulnificus, which causes serious wound infection and septicemia in humans, was isolated fortuitously from a clinical strain YJ016. This mutant was defective in cytotoxicity, migration on soft agar and virulence in the mouse. The purpose of this study was to map the mutation in this attenuated mutant and further explore how the gene thus identified is involved in virulence. METHODS: The whole genome sequence of mutant NY303 determined by next-generation sequencing was compared with that of strain YJ016 to map the mutations...
August 11, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28799518/a-neurodevelopment-and-neuroplasticity-based-framework-for-early-intervention-in-psychotic-disorders
#7
E Bora
In recent years there has been growing interest in early intervention in psychotic disorders and a number of clinical and research programmes have been developed. The clinical staging model has been an essential part of early intervention as it provides the rationale of existing programmes. In medicine, clinical staging is a valuable approach in disorders where primary pathology is progressive in nature. However, the clinical staging model of psychosis has been proposed without establishing first that schizophrenia is a primarily progressive disorder...
August 11, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28794695/water-filtered-infrared-a-wira-overcomes-swallowing-disorders-and-hypersalivation-a-case-report
#8
Gerd Hoffmann
Case description: A patient with a Barrett oesophageal carcinoma and a resection of the oesophagus with gastric pull-up developed swallowing disorders 6 years and 2 months after the operation. Within 1 year and 7 months two recurrences of the tumor at the anastomosis were found and treated with combined chemoradiotherapy or chemotherapy respectively. 7 years and 9 months after the operation local tumor masses and destruction were present with no ability to orally drink or eat (full feeding by jejunal PEG tube): quality of life was poor, as saliva and mucus were very viscous (pulling filaments) and could not be swallowed and had to be spat out throughout the day and night resulting in short periods of sleep (awaking from the necessity to spit out)...
2017: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/28791848/closed-reduction-and-percutaneous-annulated-screw-fixation-in-the-treatment-of-comminuted-proximal-humeral-fractures
#9
Zhe Yu, Lianhe Zheng, Xiaodong Yan, Xiaoxiang Li, Jian Zhao, Bao'an Ma
BACKGROUND: Displaced proximal humeral fractures remain a challenge to orthopedic surgeons. OBJECTIVES: The purpose of this study was to evaluate the functional and radiological outcomes of patients with comminuted proximal humeral fractures treated with closed reduction and percutaneous screw fixation (CRPF). MATERIAL AND METHODS: The authors retrospectively reviewed 38 cases of displaced proximal humeral fractures (2-, 3- or 4-part fractures according to the Neer classification) that were treated using the CRPF technique from May 2009 to April 2013...
March 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28790435/emergence-of-a-streptococcus-dysgalactiae-subspecies-equisimilis-stg62647-lineage-associated-with-severe-clinical-manifestations
#10
Oddvar Oppegaard, Haima Mylvaganam, Steinar Skrede, Paul Christoffer Lindemann, Bård Reiakvam Kittang
Increasing incidence rates of invasive Streptococcus dysgalactiae subspecies equisimilis (SDSE) infections have been reported worldwide, but the evolutionary mechanisms underlying this development remain elusive. Through prospective surveillance of invasive SDSE infections in western Norway, we observed the emergence of a novel and virulent SDSE genotype, stG62647. This emm-type, rarely encountered as a cause of invasive disease during 1999-2012, emerged in 2013 as the predominant SDSE-genotype. The stG62647-infections were associated with an aggressive clinical course, including the occurrence of streptococcal toxic shock syndrome, necrotizing soft-tissue infections and endocarditis...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28783644/robust-adaptive-embedded-label-propagation-with-weight-learning-for-inductive-classification
#11
Zhao Zhang, Fanzhang Li, Lei Jia, Jie Qin, Li Zhang, Shuicheng Yan
We propose a robust inductive semi-supervised label prediction model over the embedded representation, termed adaptive embedded label propagation with weight learning (AELP-WL), for classification. AELP-WL offers several properties. First, our method seamlessly integrates the robust adaptive embedded label propagation with adaptive weight learning into a unified framework. By minimizing the reconstruction errors over embedded features and embedded soft labels jointly, our AELP-WL can explicitly ensure the learned weights to be joint optimal for representation and classification, which differs from most existing LP models that perform weight learning separately by an independent step before label prediction...
August 2, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28781916/nursing-review-section-of-surgical-neurology-international-part-2-lumbar-spinal-stenosis
#12
REVIEW
Nancy E Epstein, Renee D Hollingsworth
BACKGROUND: The lumbar spine includes 5 lumbar vertebral bodies, L1, L2, L3, L4, and L5. At each level, there is a disc space defined by the two bones (vertebral bodies) in the back; for example, there is a disc space at the L5-S1 level etc. The normal front to back (anterior to posterior or AP diameter) measurement of the spinal canal is typically 18-20 mm, but some patients have narrowing called spinal stenosis. METHODS: Lumbar stenosis is defined by two major types...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28780254/modeling-the-response-of-exogenously-crosslinked-tissue-to-cyclic-loading-the-effects-of-permanent-set
#13
Will Zhang, Michael S Sacks
Bioprosthetic heart valves (BHVs), fabricated from exogenously crosslinked collagenous tissues, remain the most popular heart valve replacement design. However, the life span of BHVs remains limited to 10-15 years, in part because the mechanisms that underlie BHV failure remain poorly understood. Experimental evidence indicates that BHVs undergo significant changes in geometry with in vivo operation, which lead to stress concentrations that can have significant impact on structural damage. These changes do not appear to be due to plastic deformation, as the leaflets only deform in the elastic regime...
July 11, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28780065/eating-and-health-behaviors-in-vegans-compared-to-omnivores-dispelling-common-myths
#14
Sydney Heiss, Jaime A Coffino, Julia M Hormes
Studies comparing eating behaviors in individuals avoiding meat and other animal products to omnivores have produced largely inconclusive findings, in part due to a failure to obtain sufficiently large samples of vegan participants to make meaningful comparisons. This study examined eating and health behaviors in a large community sample of dietary vegans ("vegans"), compared to omnivores. Participants (n = 578, 80.4% female) completed an online questionnaire assessing a range of eating- and other health-related attitudes and behaviors...
August 2, 2017: Appetite
https://www.readbyqxmd.com/read/28774857/alveolar-soft-part-sarcoma-metastatic-to-the-mandible-a-report-and-review-of-literature
#15
S M Peters, M A Perrino, A J Yoon, E M Philipone
Alveolar soft part sarcoma (ASPS) is a rare neoplasm constituting less than 1% of all soft tissue sarcomas. It tends to occur in the deep soft tissues of the lower extremities, however approximately 5-12% of cases are primary to the head and neck region. ASPS metastatic to the oral cavity is rare, with only four documented cases in the literature. Here, we present the case of a 29-year-old woman with ASPS metastatic to the mandible. To the best of our knowledge, this represents only the 5th documented case of ASPS metastatic to the oral cavity, and more specifically, the 3rd documented case of mandibular metastasis...
July 31, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28774580/advancing-imaging-technologies-for-patients-with-spinal-pain-with-a-focus-on-whiplash-injury
#16
James M Elliott, Mark J Hancock, Rebecca J Crawford, Andrew C Smith, David M Walton
BACKGROUND CONTEXT: Radiological observations of soft-tissue changes that may relate to clinical symptoms in patients with traumatic and non-traumatic spinal disorders are highly controversial. Studies are often of poor quality and findings inconsistent. A plethora of evidence suggests some pathoanatomical findings from traditional imaging applications are common in asymptomatic participants across the life span, which further questions the diagnostic, prognostic, and theranostic value of traditional imaging...
July 31, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28774250/vascularized-spare-parts-reconstruction-of-hand-gunshot-injury
#17
Nathan Patrick, Alexander Payatakes
Reconstruction of extensive traumatic bone and soft tissue deficits in the hand often presents a significant challenge. We present a case of a gunshot wound managed with a resourceful "vascularized spare parts" reconstruction in which a single compromised digit provided two separate vascularized tissue transfers. A rarely reported pedicled phalanx restored osseous stability, a digital fillet flap achieved soft tissue coverage, and the flexor tendons reanimated the hand. An excellent functional and cosmetic result was obtained and the patient was able to return to manual labor within six months of injury...
September 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28766885/technical-note-construction-of-heterogeneous-head-phantom-for-quality-control-in-stereotactic-radiosurgery
#18
Mohsen Najafi, Javad Teimouri, Alireza Shirazi, Ghazaleh Geraily, Mahbod Esfahani, Mostafa Shafaei
PURPOSE: Stereotactic radiosurgery is a high precision modality for conformally delivering high doses of radiation to the brain lesion with a large dose volume. Several studies for the quality control of this technique were performed to measure the dose delivered to the target with a homogenous head phantom and some dosimeters. Some studies were also performed with one or two instances of heterogeneity in the head phantom to measure the dose delivered to the target. But these studies assumed the head as a sphere and simple shape heterogeneity...
August 2, 2017: Medical Physics
https://www.readbyqxmd.com/read/28766250/exploring-the-histogenesis-and-diagnostic-strategy-using-immunoassay-and-rt-pcr-in-alveolar-soft-part-sarcoma
#19
Xinxin Ju, Kunming Sun, Ruixue Liu, Shugang Li, Gulinaer Abulajiang, Hong Zou, Jiaojiao Lan, Yan Ren, Jinfang Jiang, Weihua Liang, Lijuan Pang, Feng Li
Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma, but it's easily misdiagnosed in rare locations. The derivation of ASPS is still uncertain, therefore we conducted this study to explore the histogenesis of ASPS by analyzing stem cell markers (ALDH1, CD29, CD133 and Nestin). Protein TFE3 and fusion gene ASPS-TFE3 were tested in paraffin to explore diagnostic strategy and molecular pathological features. In this study, nine cases of ASPS were immunostained with stem cell surface markers (ALDH1, CD29, CD133 and Nestin) and protein TFE3...
August 1, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28765443/integration-of-digital-dentistry-into-a-predoctoral-implant-program-program-description-rationale-and-utilization-trends
#20
Fatemeh S Afshari, Cortino Sukotjo, Maria F Alfaro, Jeri McCombs, Stephen D Campbell, Kent L Knoernschild, Judy Chia-Chun Yuan
A recently revised predoctoral implant curriculum at the University of Illinois at Chicago College of Dentistry integrated digital dentistry into both the preclinical dental implant course and clinical activities. Traditionally, competence in the didactic and clinical parts of predoctoral education in single tooth implant restorations has emphasized the analog impression technique and subsequent mounting of soft tissue working casts. However, computer-aided design/computer-aided manufacturing (CAD/CAM) implant restorations can play a significant role in predoctoral dental education utilizing digital technologies...
August 2017: Journal of Dental Education
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