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https://www.readbyqxmd.com/read/29166120/mechanical-response-of-transient-telechelic-networks-with-many-part-stickers
#1
Michelle K Sing, Jorge Ramírez, Bradley D Olsen
A central question in soft matter is understanding how several individual, weak bonds act together to produce collective interactions. Here, gel-forming telechelic polymers with multiple stickers at each chain end are studied through Brownian dynamics simulations to understand how collective interaction of the bonds affects mechanical response of the gels. These polymers are modeled as finitely extensible dumbbells using an explicit tau-leap algorithm and the binding energy of these associations was kept constant regardless of the number of stickers...
November 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29161292/individual-marking-of-soft-bodied-subtidal-invertebrates-in-situ-a-novel-staining-technique-applied-to-the-giant-plumose-anemone-metridium-farcimen-tilesius-1809
#2
Christopher D Wells, Kenneth P Sebens
The ability to recognize individuals and track growth over time is crucial to population dynamics research as well as studies of animal behavior. Invertebrates are particularly difficult to track as they often molt, have regenerative capabilities, or lack hard parts to attach markers. We tested, in laboratory and field studies, a new way of marking sea anemones (order Actiniaria) by injection of three vital stains (i.e., neutral red, methylene blue, and fluorescein). Neutral red and methylene blue did not affect growth or survival, but fluorescein was lethal at high concentrations...
2017: PloS One
https://www.readbyqxmd.com/read/29158832/clinical-translation-and-first-in-human-use-of-44-sc-sc-psma-617-for-pet-imaging-of-metastasized-castrate-resistant-prostate-cancer
#3
Elisabeth Eppard, Ana de la Fuente, Martina Benešová, Ambreen Khawar, Ralph A Bundschuh, Florian C Gärtner, Barbara Kreppel, Klaus Kopka, Markus Essler, Frank Rösch
BACKGROUND: Various trivalent radiometals are well suited for labeling of DOTA-conjugated variants of Glu-ureido-based prostate-specific membrane antigen (PSMA) inhibitors. The DOTA-conjugate PSMA-617 has proven high potential in PSMA radioligand therapy (PSMA-RLT) of prostate cancer as well as PET imaging when labeled with lutetium-177 and gallium-68 respectively. Considering the relatively short physical half-life of gallium-68 this positron emitter precludes prolonged acquisition periods, as required for pre-therapeutic dosimetry or intraoperative applications...
2017: Theranostics
https://www.readbyqxmd.com/read/29158308/glioblastoma-multiforme-derived-extracellular-vesicles-drive-normal-astrocytes-towards-a-tumour-enhancing-phenotype
#4
Soliman Oushy, Justin E Hellwinkel, Mary Wang, Ger J Nguyen, Dicle Gunaydin, Tessa A Harland, Thomas J Anchordoquy, Michael W Graner
Glioblastoma multiforme (GBM) is a devastating tumour with abysmal prognoses. We desperately need novel approaches to understand GBM biology and therapeutic vulnerabilities. Extracellular vesicles (EVs) are membrane-enclosed nanospheres released locally and systemically by all cells, including tumours, with tremendous potential for intercellular communication. Tumour EVs manipulate their local environments as well as distal targets; EVs may be a mechanism for tumourigenesis in the recurrent GBM setting. We hypothesized that GBM EVs drive molecular changes in normal human astrocytes (NHAs), yielding phenotypically tumour-promoting, or even tumourigenic, entities...
January 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29153869/-benign-tumors-of-the-soft-tissue-of-the-hand-about-70%C3%A2-cases
#5
M Khezami, H Bellaaj, A Abdennadher, K Amri, M Hamdi, L Nouisri
Through a retrospective study of 70 cases of benign soft tissue tumors in the orthopedic traumatology department of the military hospital of Tunis over a 12-year period from January 2005 to December 2016, we have compared our findings to those of the literature in an attempt to identify epidemiological notions relevant to daily medical practice as epidemiological data on benign tumors of the soft parts of the hand remain few and sometimes discordant. The authors report a series of 70 active, young adults, mostly female, with a swelling at the level of the hand as the most common reason for consultation...
November 16, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29153256/intraoperative-force-and-electrocochleography-measurements-in-an-animal-model-of-cochlear-implantation
#6
J Lo, C Bester, A Collins, C Newbold, A Hampson, S Chambers, H Eastwood, S O'Leary
To preserve residual hearing, techniques for monitoring and reducing the effects of trauma during cochlear implant surgery are being developed. This study examines the relationships between intraoperative recordings (electrode insertion force and electrocochleography), trauma, and hearing loss after cochlear implantation. The study also evaluated the efficacy of intravenous steroids for reducing hearing loss after implantation. Thirty-two normal-hearing guinea pigs were randomly implanted with electrode arrays of differing stiffness ('hard' or 'soft')...
November 9, 2017: Hearing Research
https://www.readbyqxmd.com/read/29152060/inhibition-of-chk1-sensitizes-ewing-sarcoma-cells-to-the-ribonucleotide-reductase-inhibitor-gemcitabine
#7
Kelli L Goss, Stacia L Koppenhafer, Kathryn M Harmoney, William W Terry, David J Gordon
Ewing sarcoma is a bone and soft tissue sarcoma that occurs in children and young adults. The EWS-FLI1 gene fusion is the driver mutation in most Ewing sarcoma tumors and functions, in part, as an aberrant transcription factor. We recently identified that Ewing sarcoma cells are sensitive to inhibition of ribonucleotide reductase (RNR), which catalyzes the formation of deoxyribonucleotides from ribonucleotides. In this report, we show that Ewing sarcoma cells are sensitive to treatment with clofarabine, which is a nucleoside analogue and allosteric inhibitor of RNR...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29151829/validation-of-poiba-how-do-we-eat-questionnaire-in-9-10-years-old-schoolchildren
#8
Carles Ariza, Teresa Arechavala, Sara Valmayor, Gemma Serral, Albert Moncada, Luis Rajmil, Anna Schiaffino, Francesca Sánchez-Martínez
Background: It is difficult to obtain good food reports with Food Frequency Questionnaires (FFQ) among children. In addition, validated questionnaires are scarce. Objective: The aim of this study was to validate the 'POIBA-How do we eat?' (POIBA-HDWE) FFQ and whether it could be administered to children under 10 years of age. Design: We validated the FFQ POIBA-HDWE as part of the Childhood Obesity Prevention Program (POIBA project) in Barcelona. Forty-two out of 63 primary school students (9-10 years old) answered three questionnaires: FFQ POBA-HDWE; another questionnaire, 'POIBA-How do our children eat?' (POIBA-HDOCE), which was administered to the children's parents; and the 24-h recall computer program 'Young Adolescents' Nutrition Assessment on Computer' (YANA-C), which was used on three different days as a gold standard...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29150442/functional-analyses-of-a-human-vascular-tumor-fos-variant-identify-a-novel-degradation-mechanism-and-a-link-to-tumorigenesis
#9
David G P van Ijzendoorn, Zary Forghany, Frauke Liebelt, Alfred C Vertegaal, Aart G Jochemsen, Judith V M G Bovée, Karoly Szuhai, David A Baker
Epithelioid hemangioma is a locally aggressive vascular neoplasm, found in bones and soft tissue, whose cause is currently unknown, but may involve oncogene activation. FOS was one of the earliest viral oncogenes to be characterized and normal cellular FOS forms part of the activator protein 1 (AP-1) transcription factor complex which plays a pivotal role in cell growth, differentiation and survival as well as the DNA damage response. Despite this, to date, a causal link between aberrant FOS function and naturally occurring tumors has not been established...
November 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29149812/architectures-and-mechanical-properties-of-drugs-and-complexes-of-surface-active-compounds-at-air-water-and-oil-water-interfaces
#10
Dipak K Sarker
BACKGROUND: Drugs can represents a multitude of compounds from proteins and peptides, such as growth hormones and insulin and on to simple organic molecules such as flurbiprofen, ibuprofen and lidocaine. Given the chemical nature of these compounds two features are always present. A portion or portions of the molecule that has little affinity for apolar surfaces and media and the opposite a series of part or one large part that has considerable affinity for hydrophilic, polar or charged media and surfaces...
November 17, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29147823/primary-peri-implant-oral-intra-epithelial-neoplasia-carcinoma-in-situ-a-case-report-considering-risk-factors-for-carcinogenesis
#11
Makoto Noguchi, Hiroaki Tsuno, Risa Ishizaka, Kumiko Fujiwara, Shuichi Imaue, Kei Tomihara, Takashi Minamisaka
BACKGROUND: Major risk factors for oral squamous cell carcinoma (SCC) are tobacco smoking, a betel quid chewing habit, and heavy alcohol consumption. However, around 15% of oral SCCs cannot be explained by these risk factors. Although oral SCC associated with dental implants is quite rare, there has been a recent gradual accumulation of reports about it. Here, we report a case of primary peri-implant oral intra-epithelial neoplasia/carcinoma in situ (OIN/CIS) in a woman without the major risk factors for oral SCC...
November 16, 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/29146192/calcium-imaging-method-to-visualize-the-spatial-patterns-of-neural-responses-in-the-pygmy-squid-idiosepius-paradoxus-central-nervous-system
#12
Motoki Koizumi, Shuichi Shigeno, Makoto Mizunami, Nobuaki K Tanaka
BACKGROUND: Cephalopods exhibit unique behaviors such as camouflage and tactile learning. The brain functions correlated to these behaviors have long been analyzed through behavioral observations of animals subject to surgical manipulation or electrical stimulation of brain lobes. However, physiological methods have rarely been introduced to investigate the functions of each individual lobe, though physiological work on giant axons and slices of the vertical lobe system of the cephalopods have provided deep insights into ion conductance of nerves and long-term synaptic plasticity...
November 13, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29145339/alveolar-soft-part-sarcoma-with-multiple-brain-and-lung-metastases-in-pregnancy-a-case-report-and-literature-review
#13
Yubo Wang, Jiayue Cui, Xu Yan, Rihua Jin, Xinyu Hong
RATIONAL: Alveolar soft part sarcomas (ASPSs) with multiple brain metastases in pregnancy is a rare entity. PATIENT CONCERNS: We report our experience with a 19-year-old pregnant woman who presented with intermittent headaches and vomiting at 38 weeks gestation. DIAGNOSES: The patient was initially diagnosed as brain metastasis according to computed tomography and magnetic resonance imaging (MRI) imaging. INTERVENTIONS: Cesarean section and craniotomy (complete resection of both brain metastatic lesions) was performed sequentially...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143046/shaping-membrane-vesicles-by-adsorption-of-a-semiflexible-polymer
#14
Bing Li, Steven M Abel
The adsorption of polymers onto fluid membranes is a problem of fundamental interest in biology and soft materials, in part because the flexibility of membranes can lead to nontrivial coupling between polymer and membrane configurations. Here, we use Monte Carlo computer simulations to study the adsorption of a semiflexible polymer onto a fluid membrane vesicle. Polymer adsorption can significantly impact both the vesicle and polymer shapes, and we identify distinct classes of configurations that emerge as a function of polymer persistence length, membrane bending rigidity, adsorption strength, and vesicle size...
November 16, 2017: Soft Matter
https://www.readbyqxmd.com/read/29142582/pseudoaneurysm-of-left-proximal-common-carotid-artery-following-penetrating-trauma
#15
Rehana Shaikh, Saba Sohail, Parvez Ahmed Shaikh, Qamar-Un-Nisa Nisa
A 33-year male with history of penetrating trauma to left upper chest in 2006, presented through Medical unit to Radiology Department with complain of hemoptysis. Chest X-ray showed a soft tissue lesion in left upper lobe with a linear metallic foreign body. Contrast enhanced CT scan of chest and later CTA was performed which showed a saccular aneurysm arising from mediastinal part of left common aortic artery surrounded by thrombosis with a cylindrical linear metallic foreign body. He was planned for endovascular repair with stenting which he could not afford due to financial constraints...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29140279/free-standing-and-self-crosslinkable-hybrid-films-by-core-shell-particle-design-and-processing
#16
Steffen Vowinkel, Stephen Paul, Torsten Gutmann, Markus Gallei
The utilization and preparation of functional hybrid films for optical sensing applications and membranes is of utmost importance. In this work, we report the convenient and scalable preparation of self-crosslinking particle-based films derived by directed self-assembly of alkoxysilane-based cross-linkers as part of a core-shell particle architecture. The synthesis of well-designed monodisperse core-shell particles by emulsion polymerization is the basic prerequisite for subsequent particle processing via the melt-shear organization technique...
November 15, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29138708/chondroma-of-the-bladder-an-atypical-localization
#17
M Tamayo-Jover, A Nazco-Deroy, R González-Álvarez, H Álvarez-Argüelles Cabrera, B Padilla-Fernández, T Concepción-Masip
Chondroma is a benign tumour of mesenchymal origin that is composed of cartilage and rarely located in soft tissues, being described so far only in four cases, as located in the bladder, according to our knowledge. We describe the fifth case of a 67-year-old woman who consulted for microscopic haematuria, with an endoscopic finding of submucosal nodular image in the anterior wall of the bladder, which after resection and the histologic study shows cartilage and fibroconnective tissue, in part hyalinised, and positive immunohistochemical staining of cells with vimentin and S-100; this fact can support the diagnosis of bladder chondroma...
2017: Case Reports in Urology
https://www.readbyqxmd.com/read/29138214/sport-science-internships-for-learning-a-critical-view
#18
EDITORIAL
James J Malone
Sport science has gained vast popularity with students who have an interest in both physiology and the underpinning mechanisms of exercise concerning performance and health. The high numbers of graduates each year, coupled with the low number of graduate positions working in sports, has led to a high level of competition between students. To stand out from the crowd, sport science students may undertake an internship placement as part of their course, designed to enhance theoretical, practical, and soft skills in an applied setting...
December 1, 2017: Advances in Physiology Education
https://www.readbyqxmd.com/read/29137020/alveolar-soft-part-sarcoma-occurring-in-the-penis-of-a-3-year-old-boy-a-rare-case-report
#19
Linli Qiu, Yuman Li, Shima Ibrahim Ali, Mingxing Xie
RATIONALE: Alveolar soft part sarcoma (ASPS) is a rare, malignant neoplasm, which mostly occurs in the upper and lower extremities. This article presents an unusual case of ASPS involving the penis of a 3-year-old boy. To our knowledge, this is the first case of ASPS in the penis of a child. PATIENT CONCERNS: The patient complained of slight penile pain for 1 year and a soft tissue mass could be palpated in his penis. DIAGNOSES: Imaging was performed on the penis...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29134627/the-evolution-of-genital-shape-variation-in-female-cetaceans
#20
Dara N Orbach, Brandon Hedrick, Bernd Würsig, Sarah L Mesnick, Patricia Lr Brennan
Male genital diversification is likely the result of sexual selection. Female genital diversification may also result from sexual selection, although it is less well studied and understood. Female genitalia are complex among whales, dolphins, and porpoises, especially compared to other vertebrates. The evolutionary factors affecting the diversity of vaginal complexity could include ontogeny, allometry, phylogeny, sexual selection, and natural selection. We quantified shape variation in female genitalia using 2-D geometric morphometric analysis, and validated the application of this method to study soft tissues...
November 14, 2017: Evolution; International Journal of Organic Evolution
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