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JOURNAL ARTICLE
Nehali Patel, Rhiannon R Penkert, Robert E Sealy, Sherri L Surman, Bart G Jones, Karen Ringwald-Smith, A Catharine Ross, Julia L Hurwitz
Healthy pediatric immune responses depend on adequate vitamin A and D levels. Relationships between solar ultraviolet B (UVB) radiation and vitamin D are well understood, while relationships between sunlight, vitamin A, and its serum escort, retinol binding protein (RBP), are not. A pediatric clinical study enrolled 2-8-year-old children at various times between September 2016 and March 2017, inclusive, in Memphis, Tennessee. A serum sample from each child was then assayed to examine the influence of season on vitamin levels...
September 19, 2022: Biomedicines
#22
JOURNAL ARTICLE
Wen-Hao Li, Jing-Yun Su, Yan-Mei Li
ConspectusCancer vaccines provide an efficient strategy to enhance tumor-specific immune responses by redeploying immune systems. Despite the approval of the first cancer vaccine (Sipuleucel-T) by the U.S. Food and Drug Administration in 2010, most therapeutic cancer vaccines fail in clinical trials. Basically, tumor-specific immune responses rely on not only T-cell but also B-cell immunity, which indicates that cancer vaccines should leverage both arms of the adaptive immune system. For example, CD8+ T cells activated by antigen-presenting cells (APCs) recognize and directly kill tumor cells via peptide-bound major histocompatibility complex (pMHC)...
September 1, 2022: Accounts of Chemical Research
#23
JOURNAL ARTICLE
Thomas L Rudge, Nicholas J Machesky, Karen A Sankovich, Erin E Lemmon, Christopher S Badorrek, Rachel Overman, Nancy A Niemuth, Michael S Anderson
Since the discovery of the Marburg virus (MARV) in 1967 and Ebola virus (EBOV) in 1976, there have been over 40 reported outbreaks of filovirus disease with case fatality rates greater than 50%. This underscores the need for efficacious vaccines against these highly pathogenic filoviruses. Due to the sporadic and unpredictable nature of filovirus outbreaks, such a vaccine would likely need to be vetted through the U.S. Food and Drug Administration (FDA), following the Animal Rule or similar European Medicines Agency (EMA) regulatory pathway...
July 29, 2022: Vaccines
#24
REVIEW
Petra Zieglmayer
Allergic diseases are among the most common diseases worldwide. For appropriate management knowledge of the allergy trigger is crucial. The clinical picture of allergic diseases is diverse and correct diagnosis is often a challenge. The allergist needs to distinguish intolerances from allergies and infectious diseases from non-infectious triggers. Test results have to be interpreted accordingly to differentiate sensitizations from allergies. In this review current state of the art diagnostic measures to diagnose type I and type IV allergies are described and discussed...
August 2022: Laryngo- Rhino- Otologie
#25
JOURNAL ARTICLE
Erasto V Mbugi, Gerco den Hartog, Jacobien Veenemans, Jaffu O Chilongola, Hans Verhoef, Huub F J Savelkoul
Immunoglobulin G (IgG) subclasses have been suggested to confer naturally acquired immunity to Plasmodium falciparum malaria. Cytophilic IgG1 and IgG3 with their potential for opsonization, phagocytosis, and antibody-dependent cellular inhibition in association with monocytes have been suggested to have a critical role in malaria. The potential for production of antibodies is influenced by micronutrient status. This study aimed at exploring the effect of micronutrients, particularly zinc status, on the profiles of IgG subclasses in 304 Tanzanian children aged ≤ 5 years...
2022: Frontiers in Nutrition
#26
JOURNAL ARTICLE
Zhaoliang Chai, Hongyan Bi
In the present study, E. coli was taken as a model bacterium, anti- E. coli functionalized magnetic beads were constructed and used to capture E. coli from aqueous extracts of fish sarcoplasmic protein (FSP) and fish muscle protein of sablefish. The excellency of the reproducibility of the present protocol was demonstrated by capturing E. coli from sablefish FSP extracts. The presence of 10 CFU/mL E. coli is still detectable. A microbial safety test on the surface of fish muscle was successfully performed...
March 30, 2022: Food chemistry: X
#27
JOURNAL ARTICLE
Milena Peruhova, Antoaneta Mihova, Iskra Altankova, Tsvetelina Velikova
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder whose pathogenesis is considered multifactorial, including abnormal gut motility, visceral hyperreactivity, psychological factors, disturbances in the brain-gut axis, leaky gut, oxidative stress, etc. We aimed to investigate serum levels of specific immunoglobulin E and G to common food antigens and zonulin and to assess their use in clinical practice for patients with IBS. MATERIAL AND METHODS: We included 23 participants, 15 with IBS (diagnosed according to the Rome IV criteria) and 8 healthy controls...
March 29, 2022: Antibodies
#28
REVIEW
Sandra G Tedner, Anna Asarnoj, Helena Thulin, Marit Westman, Jon R Konradsen, Caroline Nilsson
Adverse reactions after food intake are commonly reported and a cause of concern and anxiety that can lead to a very strict diet. The severity of the reaction can vary depending on the type of food and mechanism, and it is not always easy to disentangle different hypersensitivity diagnoses, which sometimes can exist simultaneously. After a carefully taken medical history, hypersensitivity to food can often be ruled out or suspected. The most common type of allergic reaction is immunoglobulin E (IgE)-mediated food allergy (prevalence 5-10%)...
March 2022: Journal of Internal Medicine
#29
JOURNAL ARTICLE
Jiadi Sun, Miao Li, Fuguo Xing, Haiming Wang, Yinzhi Zhang, Xiulan Sun
The coexistence of mycotoxins in agricultural products poses a serious threat to food safety. This study developed a dual immunochromatographic test strips (DICTS) method based on double antibodies labeled with time-resolved fluorescent microspheres (TRFM) to realize simultaneous rapid detection of aflatoxin M1 (AFM1) and ochratoxin A (OTA) in milk. As bridge antibody, the polyclonal antibody (pAb) was first conjugated with the TRFM and then with the monoclonal antibody (mAb). Meanwhile, a biotin-streptavidin system was introduced to replace the traditional goat anti-mouse Immunoglobulin G, thus providing a stable signal on the control line...
May 1, 2022: Food Chemistry
#30
JOURNAL ARTICLE
Zheying Liu, Shih-Kuan Li, Chih-Kang Huang, Ching-Feng Huang
Mounting evidence demonstrates that a high-salt diet (HSD) not only affects hemodynamic changes but also disrupts immune homeostasis. The T helper 17 (Th17) and regulatory T cells (Tregs) are susceptible to hypersalinity. However, research on the influence of sodium on Th2-mediated food allergies remains scarce. We aimed to investigate the effect of dietary sodium on the immune response to food allergies. Mice maintained on an HSD (4% NaCl), low-salt diet (LSD; 0.4% NaCl), or control diet (CTRL; 1.0% NaCl) were orally sensitized with ovalbumin (OVA) and a cholera toxin (CT) adjuvant, and then subjected to an intragastric OVA challenge...
October 20, 2021: Nutrients
#31
JOURNAL ARTICLE
Casey G Cohen, Wei W Zhao, Danbing Ke, Liane Beaudette, Duncan Lejtenyi, Christine McCusker, Xun Zhang, Edmond S Chan, Julia E M Upton, Eyal Grunebaum, Ann E Clarke, Bruce D Mazer, Moshe Ben-Shoshan
BACKGROUND: Food desensitization via oral immunotherapy (OIT) is gaining acceptance in clinical practice. Owing to adverse reactions, the duration of the buildup phase until a maintenance dose is achieved may be prolonged, and in a minority of cases, OIT is stopped. OBJECTIVE: We aimed to assess factors associated with the probability of reaching the maintenance dose in cow's milk (CM) OIT. METHODS: We collected data from patients undergoing CM OIT at the Montreal Children's Hospital, BC Children's Hospital, and Hospital for Sick Children...
January 2022: Journal of Allergy and Clinical Immunology in Practice
#32
Mirella Brzozowska, Natalia Mokrzycka, Grzegorz Porebski
Alpha-gal syndrome is an immunoglobulin E (IgE)-dependent allergy to galactose-α-1,3-galactose, resulting in a delayed anaphylactic reaction to red meat. The syndrome is causally linked to bites from ticks and associated with cross-reactivity to some drugs, e.g. cetuximab. Although cases of alpha-gal allergy have already been reported in a few European countries, to our best knowledge, no cases have been reported so far in Central-Eastern Europe. In the current report, we describe a case of alpha-gal syndrome diagnosed in Poland, to highlight the fact that it may occur in new geographic areas...
2021: Central-European Journal of Immunology
#33
JOURNAL ARTICLE
Pablo Castejón, Isabel Cabas, Victoria Gómez, Elena Chaves-Pozo, Isabel Cerezo-Ortega, Miguel Ángel Moriñigo, Eduardo Martínez-Manzanares, Jorge Galindo-Villegas, Alfonsa García-Ayala
In fish culture settings, the exogenous input of steroids is a matter of concern. Recently, we unveiled that in the gilthead seabream ( Sparus aurata ), the G protein-coupled estrogen receptor agonist G-1 (G1) and the endocrine disruptor 17α-ethinylestradiol (EE2 ) are potent modulators in polyreactive antibody production. However, the integral role of the microbiota upon immunity and antibody processing in response to the effect of EE2 remains largely unexplored. Here, juvenile seabreams continuously exposed for 84 days to oral G1 or EE2 mixed in the fish food were intraperitoneally (i...
2021: Frontiers in Immunology
#34
JOURNAL ARTICLE
Wesley H Self, Mark W Tenforde, Jillian P Rhoads, Manjusha Gaglani, Adit A Ginde, David J Douin, Samantha M Olson, H Keipp Talbot, Jonathan D Casey, Nicholas M Mohr, Anne Zepeski, Tresa McNeal, Shekhar Ghamande, Kevin W Gibbs, D Clark Files, David N Hager, Arber Shehu, Matthew E Prekker, Heidi L Erickson, Michelle N Gong, Amira Mohamed, Daniel J Henning, Jay S Steingrub, Ithan D Peltan, Samuel M Brown, Emily T Martin, Arnold S Monto, Akram Khan, Catherine L Hough, Laurence W Busse, Caitlin C Ten Lohuis, Abhijit Duggal, Jennifer G Wilson, Alexandra June Gordon, Nida Qadir, Steven Y Chang, Christopher Mallow, Carolina Rivas, Hilary M Babcock, Jennie H Kwon, Matthew C Exline, Natasha Halasa, James D Chappell, Adam S Lauring, Carlos G Grijalva, Todd W Rice, Ian D Jones, William B Stubblefield, Adrienne Baughman, Kelsey N Womack, Christopher J Lindsell, Kimberly W Hart, Yuwei Zhu, Lisa Mills, Sandra N Lester, Megan M Stumpf, Eric A Naioti, Miwako Kobayashi, Jennifer R Verani, Natalie J Thornburg, Manish M Patel
Three COVID-19 vaccines are authorized or approved for use among adults in the United States (1,2). Two 2-dose mRNA vaccines, mRNA-1273 from Moderna and BNT162b2 from Pfizer-BioNTech, received Emergency Use Authorization (EUA) by the Food and Drug Administration (FDA) in December 2020 for persons aged ≥18 years and aged ≥16 years, respectively. A 1-dose viral vector vaccine (Ad26.COV2 from Janssen [Johnson & Johnson]) received EUA in February 2021 for persons aged ≥18 years (3). The Pfizer-BioNTech vaccine received FDA approval for persons aged ≥16 years on August 23, 2021 (4)...
September 24, 2021: MMWR. Morbidity and Mortality Weekly Report
#35
JOURNAL ARTICLE
Kristy L Hamilton, Rod J Rohrich
The novel coronavirus, severe acute respiratory syndrome coronavirus 2, responsible for the coronavirus disease of 2019 (COVID-19) pandemic, has claimed over 2 million lives to date and brought the global economy to a halt, including elective surgery. As the authors emerge from lockdown, new protocols must be implemented to minimize risk by means of appropriate screening of their patients, surgical adjustments to reduce viral transmission in case of undiagnosed infection, and the development of accurate severe acute respiratory syndrome coronavirus 2 tests while awaiting the distribution of an effective vaccine...
September 1, 2021: Plastic and Reconstructive Surgery
#36
JOURNAL ARTICLE
Zhiming Zhao, Huiwen Jin, Yang Yin, Yanwei Hou, Jingyan Wang, Chunling Tang, Jun Fu
Purpose: The relationship between food allergy caused by food specific IgG antibodies and migraine has received increased attention in recent years. Here, we aimed to evaluate the effects of food specific IgG antibodies on headache, gastrointestinal symptoms, anxiety, depression, sleep disorders, dermatosis, and serum inflammatory cytokines in migraine patients, and to quantitatively assess the effect of IgG levels on the severity of headache and its comorbidities. Methods: Of 89 migraine patients, those who had one or more food specific IgG antibodies ≥50 U/mL were classified into the IgG positive group, which was then further divided into subgroups based on differing numbers of food allergens...
2021: Journal of Pain Research
#37
JOURNAL ARTICLE
Julia Martín, Noelia Tena, Agustin G Asuero
Since December 2019, we have been in the battlefield with a new threat to the humanity known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this review, we describe the four main methods used for diagnosis, screening and/or surveillance of SARS-CoV-2: Real-time reverse transcription polymerase chain reaction (RT-PCR); chest computed tomography (CT); and different complementary alternatives developed in order to obtain rapid results, antigen and antibody detection. All of them compare the highlighting advantages and disadvantages from an analytical point of view...
August 2021: Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science
#38
JOURNAL ARTICLE
Selim M'rad, Raja Chaâbane-Banaoues, Massaouda Ghrab, Hamouda Babba, Myriam Oudni-M'rad
BACKGROUND: Cystic echinococcosis (CE) has a worldwide distribution and is especially prevalent in North African countries. With a mean annual surgical incidence (ASI) of CE of 12.7 per 100,000 inhabitants, Tunisia is one of the most CE endemic countries in the Mediterranean area. Tataouine governorate is considered to be the most CE hypoendemic region in Tunisia (ASI = 0.92) despite favourable socioeconomic conditions that enable maintenance of the Echinococcus granulosus sensu lato (s...
April 21, 2021: Parasites & Vectors
#39
JOURNAL ARTICLE
Doyeong Kim, Jihoo Lee, Jyotiranjan Bal, Chom-Kyu Chong, Jong Ho Lee, Hyun Park
There is a need for accurate diagnostic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease (COVID-19). This study aimed to evaluate the diagnostic accuracy of an immunochromatography-based immunoglobulin G (IgG)/immunoglobulin M (IgM) antibody assay (GenBody™ COVI040) for detecting SARS-CoV-2 antibody seroconversion in COVID-19 patients. A total of 130 samples, serially collected from patients with confirmed COVID-19, and 100 negative control samples were tested for anti-SARS-CoV-2 IgM and IgG using the GenBody™ COVI040 assay following the South Korean Ministry of Food and Drug Safety guidelines on the review and approval of in vitro diagnostic devices for COVID-19...
March 17, 2021: Diagnostics
#40
JOURNAL ARTICLE
Sandra G Tedner, Cilla Söderhäll, Jon R Konradsen, Karen Bains, Magnus P Borres, Kai-Håkon Carlsen, Karin C Carlsen, Martin Färdig, Sabina Gerdin, Hrefna Gudmundsdóttir, Guttorm Haugen, Gunilla Hedlin, Christine Jonassen, Ina Kreyberg, Caroline-Aleksi Olsson Mägi, Live Nordhagen, Eva Rehbinder, Knut Rudi, Håvard O Skjerven, Anne Staff, Riyas Vettukattil, Marianne van Hage, Björn Nordlund, Anna Asarnoj
BACKGROUND: More knowledge about sensitisation patterns in early infancy, including impact of molecular allergology, is needed to help predict future allergy development more accurately. OBJECTIVE: We aimed to determine the prevalence and patterns of allergic sensitisation at three months of age, and explore possible associated factors. METHODS: From the Scandinavian antenatally recruited PreventADALL mother-child cohort we included 1110 three-months-infants with available serum...
March 9, 2021: Allergy
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