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https://www.readbyqxmd.com/read/29144803/endocrine-manifestations-of-primary-hyperoxaluria
#1
Shatha Murad, Yuval Eisenberg
OBJECTIVE: Primary hyperoxaluria type 1 (PH1) is a rare metabolic disorder of oxalate overproduction. It is associated with urolithiasis and nephrocalcinosis which progress to ESRD and systemic oxalosis. As oxalate deposits in tissues, non-parathyroid hormone (nonPTH) mediated hypercalcemia, oxalate osteopathy, primary hypothyroidism and primary hypogonadism develop. In this review, we will present a case of PH1 and provide an overview of this clinical entity and its endocrine manifestations...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29144197/evaluation-of-umelisa-%C3%A2-t4-neonatal-and-umelisa-%C3%A2-t4-using-polystyrene-plates-coated-with-anti-thyroxine-t4-monoclonal-antibodies
#2
Elisa M Castells, Ernesto C González, Pedro L Pérez, Lesley Del Río, Yileidis Tejeda, Yenitse Perea, Odalys Martín, Maryeris Espinosa, Jose A Rivero, Amarilys Frómeta
Congenital hypothyroidism is one of the most common preventable causes of mental retardation. The Center of Immunoassay has developed the UMELISA(®) T4 NEONATAL and UMELISA(®) T4 to determine neonatal T4 levels in dried blood and serum samples. Both reagent kits use the same polystyrene plates coated with anti- thyroxine (T4) polyclonal antibodies as solid phase. This work shows the re-standardization of the UMELISA(®) T4 NEONATAL and UMELISA(®) T4 using plates coated with anti-T4 monoclonal antibodies (T4Mabs)...
November 16, 2017: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/29143130/two-threshold-levels-of-vitamin-d-and-the-prevalence-of-comorbidities-in-outpatients-of-a-tertiary-hospital
#3
I N Furuie, M J J Mauro, S Petruzziello, S C Riechi, R R Petterle, C L Boguszewski, V Z C Borba
This study evaluated the number of comorbidities between two normal values of 25OHD in outpatients during 1 year of 25OHD measurements. Five hundred twenty-nine outpatients were included, patients with 25OHD ≥ 20 and < 30 ng/mL had the higher number of comorbidities, suggesting that for this specific population, 25OHD ≥ 30 ng/mL would be more appropriate. INTRODUCTION : This study evaluated the comorbidities between two values of 25OHD in outpatients of a tertiary hospital. METHODS: This is a cross-sectional study with measures of 25OHD in 1-year period, excluding 25OHD < 20 and > 50 ng/mL, clinical research participants, and liver disease and chronic renal failure patients...
November 15, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29142768/a-rare-double-aneuploidy-case-down-klinefelter
#4
Sevcan Tug Bozdogan, Atil Bisgin
Down's syndrome has its own dysmorphic findings and is accompanied by mental retardation and hypotonia. Klinefelter's syndrome is a syndrome caused by a numerical abnormality that affects male physical and cognitive development. This case reports a unique finding of 48,XXY, + 21 and a current literature review. A 4-month-old male patient presented with typical clinical features of Down's syndrome with hypothyroidism, atrial septal defect, ventricular septal defect, and patent ductus arteriosus without any phenotypic signs of Klinefelter's syndrome...
December 2017: Journal of Pediatric Genetics
https://www.readbyqxmd.com/read/29142577/congenital-hypothyroidism-in-neonates-of-a-tertiary-care-hospital
#5
Adeel Ahmad, Anam Wasim, Shahida Hussain, Muhammad Saeed, Bilal Munir Ahmad, Khalil Ur Rehman
Objective: To determine neonatal congenital hypothyroidism among neonates born in a tertiary care hospital of Lahore Pakistan. Methods: This cross-sectional study was carried out at Pathology Department of Allama Iqbal Medical College, Lahore in collaboration with Pediatrics and Gynecology & Obstetrics Department, Jinnah Hospital, Lahore Pakistan. A total of 770 babies were included in this study, both male and female. About 2 ml venous blood samples were collected aseptically from the neonates in sterile clotted tube...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29142547/an-evaluation-of-thyroid-autoimmunity-in-patients-with-beta-thalassemia-minor-a-case-control-study
#6
Ali Ramazan Benli, Sati Sena Yildiz, Mehmet Ali Cikrikcioglu
Objective: The tendency to autoimmune diseases has been reported to be increased in beta thalassemia minor (BTM). The aim of this study was to evaluate whether thyroid autoimmunity is higher in BTM. Methods: Patients with BTM (n=86) and a healthy control group (n=93) were included in this cross-sectional case-control study. The two groups were compared in terms of anti-thyroglobulin (anti-TG) and anti-thyroid peroxidase (anti-TPO) and thyroid hormones. Results: In the BTM group, thyroid hormones and serum anti-TG and anti-TPO antibody levels were not statistically different from those of the control group...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29142304/maternal-exposure-to-iodine-excess-throughout-pregnancy-and-lactation-induces-hypothyroidism-in-adult-male-rat-offspring
#7
Caroline Serrano-Nascimento, Rafael Barrera Salgueiro, Thiago Pantaleão, Vânia Maria Corrêa da Costa, Maria Tereza Nunes
This study aimed to investigate the consequences of maternal exposure to iodine excess (IE; 0.6 mg NaI/L) throughout pregnancy and lactation on the hypothalamus-pituitary-thyroid axis of the male offspring in adulthood. Maternal IE exposure increased hypothalamic Trh mRNA expression and pituitary Tsh expression and secretion in the adult male offspring. Moreover, the IE-exposed offspring rats presented reduced thyroid hormones levels, morphological alterations in the thyroid follicles, increased thyroid oxidative stress and decreased expression of thyroid differentiation markers (Tshr, Nis, Tg, Tpo, Mct8) and thyroid transcription factors (Nkx2...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29142189/a-carbamazepine-induced-brugada-type-electrocardiographic-pattern-in-a-patient-with-schizophrenia
#8
Hisanobu Ota, Yuichiro Kawamura, Nobuyuki Sato, Naoyuki Hasebe
We report the case of a 61-year-old man with schizophrenia who was treated with carbamazepine, in whom electrocardiography showed transient Brugada-type ST elevation. He had been hospitalized our hospital's Department of Psychiatry and had been diagnosed with pneumonia. On the following day, electrocardiography showed coved-type ST elevation in the right precordial leads and a blood examination revealed that the patient's carbamazepine concentration was at the upper limit of the standard range, as well as hypothyroidism...
2017: Internal Medicine
https://www.readbyqxmd.com/read/29141812/neuromyelitis-optica-spectrum-disorders-in-iran
#9
Sharareh Eskandarieh, Saharnaz Nedjat, Amir Reza Azimi, Abdorreza Naser Moghadasi, Mohammad Ali Sahraian
BACKGROUND: Neuromyelitys optica spectrum disorder (NMOSD) is a rare demyelinating disease; as a result, the epidemiological data on this disorder is scarce. In this regard, the aim of this study was to estimate the prevalence, serology, and clinical features of NMOSD in Caucasian population in Tehran, Iran. METHOD: A cross sectional study was performed in Tehran from 2015 to 2016 among patients registered with NMOSD diagnosis, based on consensus criteria published in 2015...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141467/oxidative-stress-biomarkers-in-amniotic-fluid-of-pregnant-women-with-hypothyroidism
#10
Tanja R Novakovic, Zana C Dolicanin, Natasa Z Djordjevic
PURPOSE: Hypothyroidism in pregnancy is the serious state that may lead to fetal morbidity and mortality. Oxidative stress biomarkers in the amniotic fluid can provide important information on the health, development and maturation of the fetus during pregnancy. In this study, we examined whether maternal hypothyroidism contributes to increased oxidative stress biomarkers in the amniotic fluid during the first trimester of pregnancy. MATERIALS AND METHODS: The study was conducted on healthy pregnant women and pregnant women with hypothyroidism (gestational age: 16-18 weeks)...
November 15, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29139373/primary-malignant-melanoma-of-the-bladder
#11
Maurizio Buscarini, Claudio Conforti, Raffaele Antonelli Incalzi, Cristina Falavolti, Chiara Taffon, Giovanni Muto, Caterina Dianzani
A 81-year-old man was admitted to our university for a second opinion after diagnosis of bladder melanoma in December 2014. His medical history included arterial hypertension, hypothyroidism, peripheral arterial disease treated with a bypass, and corneal transplantation. His medical history was negative for malignant melanoma. He experienced gross hematuria in the absence of any other clinical manifestations, and urine cytology identified atypical cells. The patient underwent transurethral resection of the bladder with diagnosis of melanoma...
2017: Skinmed
https://www.readbyqxmd.com/read/29135488/endocrine-manifestations-of-down-syndrome
#12
Rachel Whooten, Jessica Schmitt, Alison Schwartz
PURPOSE OF REVIEW: To summarize the recent developments in endocrine disorders associated with Down syndrome. RECENT FINDINGS: Current research regarding bone health and Down syndrome continues to show an increased prevalence of low bone mass and highlights the importance of considering short stature when interpreting dual energy x-ray absorptiometry. The underlying cause of low bone density is an area of active research and will shape treatment and preventive measures...
November 11, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29132427/risk-of-falling-among-hospitalized-patients-with-high-modified-morse-scores-could-be-further-stratified
#13
Irina Gringauz, Yael Shemesh, Amir Dagan, Irina Israelov, Dana Feldman, Naama Pelz-Sinvani, Dan Justo, Gad Segal
BACKGROUND: Falls during hospitalization harbor both clinical and financial outcomes. The modified Morse fall scale [MMFS] is widely used for an in-hospital risk-of-fall assessment. Nevertheless, the majority of patients at risk of falling, i.e. with high MMFS, do not fall. The aim of this study was to ascertain our study hypothesis that certain patients' characteristics (e.g. serum electrolytes, usage of a walking device etc.) could further stratify the risk of falls among hospitalized patients with MMFS...
November 13, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29132170/thyroid-dysfunction-states-and-incident-cardiovascular-events-the-tehran-thyroid-study
#14
Maryam Tohidi, Arash Derakhshan, Samaneh Akbarpour, Atieh Amouzegar, Ladan Mehran, Aidin Baghbani-Oskouei, Fereidoun Azizi, Farzad Hadaegh
The objective of the study was to investigate the relation of different thyroid function states with the incidence of cardiovascular disease (CVD)/coronary heart disease (CHD) among a Middle-Eastern population with a high incidence of CVD/CHD. A total of 3975 participants entered the study (43.6% men). According to their thyroid stimulating hormone (TSH) and free thyroxin (FT4) levels, the participants were categorized into 5 groups: euthyroid, subclinical hypothyroidism, overt hypothyroidism, subclinical hyperthyroidism, and overt hyperthyroidism...
November 13, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29131623/iodide-binding-in-sodium-coupled-cotransporters
#15
Ariela Vergara-Jaque, Peying Fong, Jeffrey Comer
Several apical iodide translocation pathways have been proposed for iodide efflux out of thyroid follicular cells, including a pathway mediated by the sodium-coupled monocarboxylate transporter 1 (SMCT1), which remains controversial. Herein, we evaluate structural and functional similarities between SMCT1 and the well-studied sodium-iodide symporter (NIS) that mediates the first step of iodide entry into the thyroid. Free-energy calculations using a force field with electronic polarizability verify the presence of a conserved iodide-binding pocket between the TM2, TM3, and TM7 segments in hNIS, where iodide is coordinated by Phe67, Gln72, Cys91, and Gln94...
November 13, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29130593/chylomicronemia-risk-factors-ranked-by-importance-for-the-individual-and-community-in-108-711-women-and-men
#16
Simon B Pedersen, Anette Varbo, Anne Langsted, Børge G Nordestgaard
BACKGROUND: Hypertriglyceridemia prevalence is increasing as more individuals become obese, and chylomicronemia risk factors for the individual and community have not been described previously. OBJECTIVE: To describe chylomicronemia risk factors in the general population for individuals and community. METHODS: 108,711 individuals from the Copenhagen General Population Study were grouped as unlikely chylomicronemia (nonfasting triglycerides <2mmol/L(177 mg/dL)), possible chylomicronemia (2-4...
November 11, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29127763/thyroid-evaluation-of-children-and-adolescents-with-williams-syndrome-in-zhejiang-province
#17
Wei-Jun Chen, Chai Ji, Dan Yao, Zheng-Yan Zhao
BACKGROUND: The objective of the study was to describe the prevalence of abnormal thyroid function and volume in children and adolescents with Williams syndrome (WS) in Zhejiang Province, China. METHODS: Thyroid function, including thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), and thyroid antibodies (thyroid peroxidase and thyroglobulin) were measured in 83 patients with WS, aged 0.2-16.5 years. Twenty-three patients were followed for an average of 1...
November 11, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29127744/-endocrine-orbitopathy-the-present-view-of-a-clinical-endocrinologist
#18
Jan Jiskra
Graves orbitopathy (GO) occurs in 25-50 % cases of Graves disease. Only in 5 % of patients the eye threatening GO is present. About 5-10 % and 10 % cases are present in euthyroid and hypothyroid patients respectively. All patients with GO should be assessed for activity (clinical activity score - CAS) and severity of the disease. Basic preconditions of the treatment are maintenance of euthyroidism, an effort to stop smoking, and referring of patients with moderate to severe and sight threatening GO to specialized thyroid eye centers...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29127609/gender-based-differences-in-a-population-based-cohort-with-celiac-disease-more-alike-than-unalike
#19
Claire L Jansson-Knodell, Katherine S King, Joseph J Larson, Carol T Van Dyke, Joseph A Murray, Alberto Rubio-Tapia
BACKGROUND: There is a gap in research focused on gender-based differences in non-referral populations with celiac disease. AIMS: The aim of this study was to estimate those differences in a unique population-based cohort of patients with celiac disease with respect to (1) presenting symptoms, (2) associated autoimmune disorders, and (3) survival. METHODS: Clinical data were systematically abstracted from the electronic medical record of a population-based incident cohort of patients with celiac disease...
November 10, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29126290/effects-of-levothyroxine-on-pregnant-women-with-subclinical-hypothyroidism-negative-for-thyroid-peroxidase-antibodies
#20
Sima Nazarpour, Fahimeh Ramezani Tehrani, Masoumeh Simbar, Maryam Tohidi, Sonia Minooee, Maryam Rahmati, Fereidoun Azizi
Context: Currently, there is no consensus on universal thyroid screening and Levothyroxine (LT4) treatment of subclinical hypothyroid pregnant women who are negative for thyroid peroxidase antibody (SCH-TPOAb-). Objective: We aimed to evaluate the benefits of LT4 treatment on pregnancy outcomes in SCH-TPOAb- women. Design: This study was conducted within the framework of the Tehran Thyroid and pregnancy study. A single-blind randomized clinical trial was undertaken on SCH-TPOAb- pregnant women...
November 6, 2017: Journal of Clinical Endocrinology and Metabolism
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