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Food antigens igg

Sven Pischke, Julian Schulze-Zur-Wiesch, Marc Lu Tgehetmann, Benno Kreuels, Stefan Lueth, Petra Kapaun, Daniel Benten, Stefan Schmiedel, Martina Sterneck, Ansgar W Lohse, Susanne Polywka
:  Background. There are only few reports about travel-associated, imported tropical hepatitis E virus (HEV) genotype 1 infections within Western travellers. We describe the clinical course of a single outbreak of hepatitis E in a German travellers group returning from India and compare the results of two commercial HEV-seroassays. MATERIAL AND METHODS: After identifying hepatitis E in an index patient returning from a journey to India all 24 members of this journey were tested for anti-HEV-IgG and IgM using two commercial seroassays (Wantai and Mikrogen), for HEV-RNA by PCR and HEV-Ag by an antigen-assay (Wantai)...
January 2017: Annals of Hepatology
Zeli Tang, Mei Shang, Tingjin Chen, Pengli Ren, Hengchang Sun, Hongling Qu, Zhipeng Lin, Lina Zhou, Jinyun Yu, Hongye Jiang, Xinyi Zhou, Xuerong Li, Yan Huang, Jin Xu, Xinbing Yu
BACKGROUND: Clonorchiasis, a food-borne zoonosis, is caused by Clonorchis sinensis. The intestinal tract and bile ducts are crucial places for C. sinensis metacercariae to develop into adult worms. The endospore of Bacillus subtilis is an ideal oral immunization vehicle for delivery of heterologous antigens to intestine. Cysteine protease of C. sinensis (CsCP) is an endogenous key component in the excystment of metacercariae and other physiological or pathological processes. METHODS: We constructed a fusion gene of CotC (a coat protein)-CsCP and obtained B...
December 19, 2016: Parasites & Vectors
Rie Yu, Ken Igawa, Yutaro Handa, Takichi Munetsugu, Takahiro Satoh, Hiroo Yokozeki
The prevalence of food allergies worldwide has increased recently. Epicutaneous sensitization to antigen could be a method to study food allergy METHODS: To clarify the mechanisms of food allergy, we established a mouse model of epicutaneous sensitization using ovalbumin. BALB/c mice were sensitized by three-time application of ovalbumin to tape-stripped skin (1-week sensitization at 2-week intervals) and oral challenge of ovalbumin undertaken. Rectal temperature was monitored. Blood and tissue (skin and jejunum) of challenged mice were taken...
December 19, 2016: Experimental Dermatology
Rasha T Alam, Ehsan H Abu Zeid, Tamer S Imam
Furan (Fu) is a liver carcinogen produced during heating process of food and concerns a public health problem. The current study was undertaken to evaluate the protective role of quercetin (Que) on Fu-induced hematological, immunological, and histopathological alterations in rats. Fifty male Sprague Dawley rats were divided into five equal groups. Group I (Cont) received distilled water, group II (CO) received corn oil, group III (Que) received Que at 50 mg/kg BW, group IV (Fu) received Fu at 16 mg/kg BW, and group V received Que + Fu simultaneously; all groups gavaged daily for 30 days...
November 26, 2016: Environmental Science and Pollution Research International
Patricia Berenice Ramírez Rodríguez, Rodrigo Rosario Cruz, Delia Inés Domínguez García, Rodolfo Hernández Gutiérrez, Rodolfo Esteban Lagunes Quintanilla, Daniel Ortuño Sahagún, Celia González Castillo, Abel Gutiérrez Ortega, Sara Elisa Herrera Rodríguez, Adriana Vallejo Cardona, Moisés Martínez Velázquez
Rhipicephalus (Boophilus) microplus ticks are obligatory hematophagous ectoparasites of cattle and act as vectors for disease-causing microorganisms. Conventional tick control is based on the use of chemical acaricides; however, their uncontrolled use has increased tSresistant tick populations, as well as food and environmental contamination. Alternative immunological tick control has shown to be partially effective. The only anti-tick vaccine commercially available at present in the world is based on intestinal Bm86 protein, and shows a variable effectiveness depending on tick strains or geographic isolates...
November 2016: Experimental Parasitology
Himaja Nallagatla, Rajkumar Hemalatha, Narendra Babu Kondapalli, Shujauddin Mohammed
BACKGROUND: Prebiotics from various regularly consumed cereals and novel substrates are currently being utilised as functional foods. The aim of this study was to determine the effect of synbiotic, formulated with prebiotic extracted from natural resources like green gram (Vigna radiata) along with probiotic Lactobacillus rhamnosus GG (LGG) in modulating immune responses in the offspring when supplemented during gestation and lactation. RESULTS: Synbiotic supplementation was effective in improving cell mediated immunity and humoral immunity among F0 dams...
October 3, 2016: Journal of the Science of Food and Agriculture
Kalmia M Smith, Raiann S Rahman, Lisa A Spencer
Eosinophils are native to the healthy gastrointestinal tract and are associated with inflammatory diseases likely triggered by exposure to food allergens (e.g., food allergies and eosinophilic gastrointestinal disorders). In models of allergic respiratory diseases and in vitro studies, direct Ag engagement elicits eosinophil effector functions, including degranulation and Ag presentation. However, it was not known whether intestinal tissue eosinophils that are separated from luminal food Ags by a columnar epithelium might similarly engage food Ags...
November 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
Jacek Gocki, Zbigniew Bartuzi
This paper presents current views on the role of immunoglobulin G (IgG) antibodies in the reactions with food antigens in the digestive tract and their role in the diagnosis of food allergy based on the assays of specific IgG class antibodies, with a special focus on contemporary practice guidelines. In the light of current scientific knowledge, the IgG-specific antibody-mediated reactions are a body's natural and normal defensive reactions to infiltrating food antigens, which are considered as pathogens. On the other hand, specific IgG antibodies against food allergens play a crucial role in the induction and maintaining of immunological tolerance to food antigens...
August 2016: Postȩpy Dermatologii i Alergologii
G V Stark, G S Sivko, M VanRaden, J Schiffer, K L Taylor, J A Hewitt, C P Quinn, E O Nuzum
Anthrax vaccine adsorbed (AVA, BioThrax) was recently approved by the Food and Drug Administration (FDA) for a post-exposure prophylaxis (PEP) indication in adults 18-65years of age. The schedule is three doses administered subcutaneous (SC) at 2-week intervals (0, 2, and 4weeks), in conjunction with a 60-day course of antimicrobials. The Public Health Emergency Medical Countermeasures Enterprise (PHEMCE) developed an animal model to support assessment of a shortened antimicrobial PEP duration following Bacillus anthracis exposure...
December 12, 2016: Vaccine
Hiroshi M Ueno, Teruhiko Kato, Hidenori Ohnishi, Norio Kawamoto, Zenichiro Kato, Hideo Kaneko, Naomi Kondo, Taku Nakano
BACKGROUND: Optimally hydrolyzed β-Lactoglobulin (βLg) is a promising milk oral immunotherapy (OIT) candidate with respect to showing reduced B-cell reactivity but retaining the T-cell epitope. To demonstrate that an edible hypoallergenic βLg hydrolysate containing the T-cell epitope is suitable for OIT. We tested how chymotrypsin affected the retention of the T-cell epitope of βLg when preparing βLg hydrolysates using food-grade trypsin. METHODS: We investigated the effect of chymotrypsin activity on the formation of the T-cell epitope-containing peptide of βLg (βLg102-124 ) and prepared an edible βLg hydrolysate containing βLg102-124 using screened food-grade trypsins...
December 2016: Pediatric Allergy and Immunology
Anke Jansen, Ana D Mandić, Eveline Bennek, Lisa Frehn, Julien Verdier, Irene Tebrügge, Holger Lutz, Konrad Streetz, Christian Trautwein, Gernot Sellge
OBJECTIVES: Inflammatory bowel disease (IBD), particularly Crohn's disease (CD), is associated with increased microbial-specific IgG and IgA antibodies, whereas alterations of anti-food antibodies are still disputed. The knowledge about IgG subclass antibodies in IBD is limited. In this study we analysed IgG subclass antibodies specific for nutritional and commensal antigens in IBD patients and controls. METHODS: Serum IgG1, IgG2, IgG3 and IgG4 specific for wheat and milk extracts, purified ovalbumin, Escherichia coli and Bacteroides fragilis lysates and mannan from Saccharomyces cerevisiae were analysed by ELISA in patients with CD (n = 56), ulcerative colitis (UC; n = 29), acute gastroenteritis/colitis (n = 12) as well as non-inflammatory controls (n = 62)...
December 2016: Scandinavian Journal of Gastroenterology
Lucia C Pawloski, Brian D Plikaytis, Monte D Martin, Stacey W Martin, Harry E Prince, Mary Lapé-Nixon, M Lucia Tondella
BACKGROUND: Pertussis serodiagnosis is increasingly being used in the United States despite the lack of a US Food and Drug Administration-approved, commercially available assay. To better understand the utility of these assays in diagnosing pertussis, serology assays were evaluated for analytical parameters and clinical accuracy. METHODS: Forty-three antigen-antibody combinations were evaluated for single-point diagnosis of pertussis. Serum panels included sera from laboratory-confirmed cases, an international reference standard, and healthy donors...
July 22, 2016: Journal of the Pediatric Infectious Diseases Society
Chunmei Song, Jinxin Liu, Jianwu Li, Qing Liu
A pattern of signal amplification lateral flow immunoassay (LFIA) for pathogen detection, which used fluorescein isothiocyanate (FITC) labeled antigen and antibody for dual FITC-LFIA was developed. Escherichia coli O157:H7 (E.coli O157:H7) was selected as the model analyte. In the signal amplification LFIA method, FITC was mixed with sample culture medium, with the presence of E.coli O157:H7 in the samples, the bacteria could emit a yellow-green fluorescence after incubation, creating a fluorescent antigen probe...
November 15, 2016: Biosensors & Bioelectronics
Mingquan Yuan, Evangelyn C Alocilja, Shantanu Chakrabartty
This paper presents a wireless, self-powered, affinity-based biosensor based on the integration of paper-based microfluidics with our previously reported method for self-assembling radio-frequency (RF) antennas. At the core of the proposed approach is a silver-enhancement technique that grows portions of a RF antenna in regions where target antigens hybridize with target specific affinity probes. The hybridization regions are defined by a network of nitrocellulose based microfluidic channels which implement a self-powered approach to sample the reagent and control its flow and mixing...
August 2016: IEEE Transactions on Biomedical Circuits and Systems
G S Sivko, G V Stark, K P Tordoff, K L Taylor, E Glaze, M VanRaden, J M Schiffer, J A Hewitt, C P Quinn, E O Nuzum
Anthrax Vaccine Adsorbed (AVA, BioThrax) is approved by the US Food and Drug Administration for post-exposure prophylaxis (PEP) of anthrax in adults. The PEP schedule is 3 subcutaneous (SC) doses (0, 14 and 28 days), in conjunction with a 60 day course of antimicrobials. The objectives of this study were to understand the onset of protection from AVA PEP vaccination and to assess the potential for shortening the duration of antimicrobial treatment (
December 12, 2016: Vaccine
Tsuguto Toda, Shin Yoshino
The mucosal immune system is exposed to non-self antigens in food and the gut microbiota. Therefore, the recognition of orally ingested non-self antigens is suppressed in healthy individuals to avoid excessive immune responses in a process called "oral tolerance". The breakdown of oral tolerance has been cited as a possible cause of food allergy, and amorphous silica nanoparticles (nSP) have been implicated in this breakdown. As nSP are widely used in foodstuffs and other products, exposure to them is increasing; thus, investigations of any effects of nSP on oral tolerance are urgent...
September 2016: Journal of Immunotoxicology
Torunn O Apelseth, Venny L Kvalheim, Einar K Kristoffersen
BACKGROUND: Allergic transfusion reactions (ATRs) present with a broad range of symptoms probably caused by mediators released from mast cells and basophil granulocytes upon activation. Passive immunoglobulin (Ig)E sensitization may yield clinical symptoms and positive allergy tests. Unexpected findings of IgE antibodies in pooled solvent/detergent (S/D)-treated plasma (Octaplas, Octapharma) during routine analysis initiated an investigation of serum proteins. STUDY DESIGN AND METHODS: Consecutive batches of S/D-plasma transfused during September 2014 through March 2015 were investigated for IgE, IgG, IgA IgM, C3, C4, haptoglobin, anti-nuclear antibodies (ANAs), and red blood cell (RBC) antibodies...
May 2016: Transfusion
Attilio Francesco Speciani, Gabriele Piuri
Measuring the level of inflammation with an innovative approach (with blood analyses to evaluate the action of cytokines such as B-cell activating factor [BAFF], platelet activating factor [PAF], interleukin-6 [IL-6], sirtuin) allows you to better understand the body's language. The body recognizes foods and food antigens through a mapping performed by means of immunoglobulin G (IgG). Recent studies have shown that high levels of IgG in a nutrient express the personal excess of that food in the daily nutrition...
2015: Journal of the American College of Nutrition
M A Tosca, A Pistorio, A Accogli, Silvestri M, G A Rossi, G Ciprandi
No abstract text is available yet for this article.
2015: Journal of Investigational Allergology & Clinical Immunology
James C Zimring
Intravenous immune globulin (IVIG) was developed initially as an immunoglobulin replacement therapy for primary humoral immunodeficiency, but is now widely used in the treatment of autoinflammatory and autoimmune pathologies. In a small number of patients, hemolytic sequelae have been observed after IVIG administration. The lack of a simple one-to-one correlation between measurable hemagglutinins and hemolysis has led to complicated hypotheses involving coincident necessary variables (e.g., a two-hit hypothesis) and also to the positing of causal factors other than hemagglutinins...
July 2015: Transfusion
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