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https://www.readbyqxmd.com/read/29289377/treatment-of-paraphilic-disorders-in-sexual-offenders-or-men-with-a-risk-of-sexual-offending-with-luteinizing-hormone-releasing-hormone-agonists-an-updated-systematic-review
#1
REVIEW
Daniel Turner, Peer Briken
BACKGROUND: Different pharmacologic agents are used in the treatment of paraphilic disorders in sexual offenders or men with a risk of sexual offending, with luteinizing hormone-releasing hormone (LHRH) agonists being the agents introduced more recently to treatment regimens. AIM: To summarize the relevant literature concerning LHRH agonist treatment of paraphilic disorders in sexual offenders and update the previously published systematic review by Briken et al (J Clin Psychiatry 2003;64:890-897)...
January 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29230871/prospective-motion-correction-enables-highest-resolution-time-of-flight-angiography-at-7t
#2
Hendrik Mattern, Alessandro Sciarra, Frank Godenschweger, Daniel Stucht, Falk Lüsebrink, Georg Rose, Oliver Speck
PURPOSE: Higher magnetic field strengths enable time-of-flight (TOF) angiography with higher resolution to depict small-vessel pathologies. However, this potential is limited by the subject's ability to remain motionless. Even small-scale, involuntary motion can degrade vessel depiction, thus limiting the effective resolution. The aim of this study was to overcome this resolution limit by deploying prospectively motion-corrected (PMC) TOF. METHODS: An optical, marker-based, in-bore tracking system was used to update the imaging volume prospectively according to the subject's head motion...
December 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29175726/the-redesigned-forensic-research-reference-on-genetics-knowledge-base-frog-kb
#3
Kenneth K Kidd, Usha Soundararajan, Haseena Rajeevan, Andrew J Pakstis, Katherine N Moore, Jeri D Ropero-Miller
The Forensic Resource/Reference on Genetics-knowledge base (FROG-kb) web site <https://frog.med.yale.edu/FrogKB/> was introduced in 2011 and in the five years since the previous publication ongoing research into how the database can better serve forensics has resulted in extensive redesign of the database interface and functionality. Originally designed as a prototype to support forensic use of single nucleotide polymorphisms (SNPs), FROG-kb provides a freely accessible web interface that facilitates forensic practice and can be useful for teaching and research...
November 14, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29168072/estimates-for-the-acoustical-stimulation-and-heating-of-multiphase-biotissue
#4
T I Zohdi, R Krone
Low-intensity, unfocused, ultrasound-induced diathermy can produce undesired temperature increases at the interface of adjacent tissues within the body; particularly, at the interface of soft tissue and bone. This study provides a computational framework for predicting an upper bound on the temperature profile within a multiphase system composed of gel pad (water), tissue and bone from an input of acoustic energy, at frequencies and power levels consistent with applications of therapeutic hyperthermia. The model consists of solving a (one-dimensional) spatially discretized bioheat transfer equation via finite-difference method and updating the solution in time with a forward-Euler scheme...
November 22, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29128269/post-orgasmic-illness-syndrome-a-review
#5
REVIEW
Hoang Minh Tue Nguyen, Areeg Bala, Andrew T Gabrielson, Wayne J G Hellstrom
INTRODUCTION: Post-orgasmic illness syndrome (POIS) is a rare but debilitating cluster of postejaculatory symptoms affecting men. It is a chronic disorder manifesting as a constellation of flulike and allergic symptoms within seconds, minutes, or hours after ejaculation. POIS can be followed by mental sequelae such as diminished concentration and irritability. POIS negatively affects the life of patients by limiting sexual encounters, dampening romantic prospects, creating internal struggles to avoid eroticism, and affecting patients' schedules...
January 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29115692/a-spiral-based-volumetric-acquisition-for-mr-temperature-imaging
#6
Samuel W Fielden, Xue Feng, Li Zhao, G Wilson Miller, Matthew Geeslin, Robert F Dallapiaza, W Jeffrey Elias, Max Wintermark, Kim Butts Pauly, Craig H Meyer
PURPOSE: To develop a rapid pulse sequence for volumetric MR thermometry. METHODS: Simulations were carried out to assess temperature deviation, focal spot distortion/blurring, and focal spot shift across a range of readout durations and maximum temperatures for Cartesian, spiral-out, and retraced spiral-in/out (RIO) trajectories. The RIO trajectory was applied for stack-of-spirals 3D imaging on a real-time imaging platform and preliminary evaluation was carried out compared to a standard 2D sequence in vivo using a swine brain model, comparing maximum and mean temperatures measured between the two methods, as well as the temporal standard deviation measured by the two methods...
November 8, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29047103/correction-to-adjacent-level-disease-background-and-update-based-on-disc-replacement-data
#7
I David Kaye, Alan S Hilibrand
This article was published and transmitted with the lead author's name listed incorrectly in the citation. The correct citation is, in full: Kaye, I.D. & Hilibrand, A.S. Curr Rev Musculoskelet Med (2017) 10: 147. https://doi.org/10.1007/s12178-017-9396-5 .
October 18, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29018770/master-of-science-msc-program-in-radiation-biology-an-interdepartmental-course-bridging-the-gap-between-radiation-related-preclinical-and-clinical-disciplines-to-prepare-next-generation-medical-scientists
#8
Stephanie E Combs, Carmen Kessel, Jan J Wilkens, Gabriele Multhoff, Thomas E Schmid, Peter Vaupel, Klaus-Rüdiger Trott, Pascal Berberat, Michael J Atkinson
Radiation biology is a highly interdisciplinary field at the interface of biology, physics, and medicine. It is characterized by rapid advances in biological and technical knowledge. The potential for using these advances to optimize medical care, radiation protection, and related fields can be exploited only with complementary activities to support the education of young academics. A small number of academic institutions have committed resources into radiation-related courses and curricula; however, few offer a comprehensive interdepartmental research and training program...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28923561/update-on-the-safety-of-phosphodiesterase-type-5-inhibitors-for-the-treatment-of-erectile-dysfunction
#9
REVIEW
Faysal A Yafi, Ira D Sharlip, Edgardo F Becher
INTRODUCTION: Phosphodiesterase type 5 inhibitors (PDE5Is) have demonstrated efficacy in the treatment of erectile dysfunction (ED). Although historically found to have limited drug-related adverse events, emerging data have suggested that PDE5Is might be associated with melanoma or recurrence of prostate cancer after radical prostatectomy. AIM: To summarize the literature on the safety of PDE5Is. METHODS: A literature review was performed through PubMed from 1990 through 2016 regarding ED...
September 8, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28819801/botulinum-toxin-treatment-in-multiple-sclerosis-a-review
#10
REVIEW
Yasaman Safarpour, Tahereh Mousavi, Bahman Jabbari
Purpose of review The purpose of this review is to provide updated information on the role of botulinum neurotoxin (BoNT) therapy in multiple sclerosis (MS). This review aims to answer which symptoms of multiple sclerosis may be amenable to BoNT therapy. Recent findings We searched the literature on the efficacy of BoNTs for treatment of MS symptoms up to April 1st 2017 via the Yale University Library's search engine including but not limited to Pub Med and Ovis SP. The level of efficacy was defined according to the assessment's criteria set forth by the Subcommittee on Guideline Development of the American Academy of Neurology...
August 17, 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28745080/improving-understanding-of-trigger-points-and-widespread-pressure-pain-sensitivity-in-tension-type-headache-patients-clinical-implications
#11
César Fernández-De-Las-Peñas, Lars Arendt-Nielsen
The underlying etiology of tension type headache (TTH) is not understood. The current paper highlights the etiologic role of muscle trigger points (TrPs) to the development and maintenance of central sensitization in TTH and its clinical repercussion for proper management of these patients. Areas covered: A literature search on Pub Med for English-language published papers between 1990 and May 2017 to provide the most updated data on the topic was conducted. Current literature suggests that the referred pain elicited by active trigger points (TrPs) contributes to the manifestations of TTH...
September 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/28642047/erectile-dysfunction-in-young-men-a-review-of-the-prevalence-and-risk-factors
#12
REVIEW
Hoang Minh Tue Nguyen, Andrew T Gabrielson, Wayne J G Hellstrom
INTRODUCTION: Erectile dysfunction (ED) is an important health concern that can significantly affect a man's psychosocial well-being. ED has traditionally been considered a disease of old age; however, contemporary evidence suggests a growing incidence of ED in men younger than 40 years. The process of achieving an erection is multifaceted; there are many potential mechanisms that can be disrupted. It is critical to identify the specific causes of ED before proceeding with potentially costly and invasive therapeutic options...
October 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28593709/respiratory-motion-model-based-on-the-noise-covariance-matrix-of-a-receive-array
#13
A Andreychenko, B Denis de Senneville, R J M Navest, R H N Tijssen, J J W Lagendijk, C A T van den Berg
PURPOSE: Tracking of the internal anatomy by means of a motion model that uses the MR-derived motion fields and noise covariance matrix (NCM) dynamic as a surrogate signal. METHODS: A 2D respiratory motion model was developed based on the MR-derived motion fields and the NCM of a receive array used in MRI. Temporal dynamics of the NCM were used as a motion surrogate for a linear correspondence motion model. The model performance was tested on five healthy volunteers with a liver as the target...
June 7, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28472402/cofactor-improved-protein-function-prediction-by-combining-structure-sequence-and-protein-protein-interaction-information
#14
Chengxin Zhang, Peter L Freddolino, Yang Zhang
The COFACTOR web server is a unified platform for structure-based multiple-level protein function predictions. By structurally threading low-resolution structural models through the BioLiP library, the COFACTOR server infers three categories of protein functions including gene ontology, enzyme commission and ligand-binding sites from various analogous and homologous function templates. Here, we report recent improvements of the COFACTOR server in the development of new pipelines to infer functional insights from sequence profile alignments and protein-protein interaction networks...
May 2, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28456610/sexual-function-obesity-and-weight-loss-in-men-and-women
#15
REVIEW
David L Rowland, Sean M McNabney, Alexx R Mann
INTRODUCTION: Obesity is a major health concern in the United States and many developed countries. Among its many deleterious effects are those that can affect the sexual response. AIM: To update and evaluate the state of knowledge on the possible link between obesity and sexual dysfunction. METHODS: A comprehensive search and review of biomedical, physiologic, and psychological databases were used to integrate findings on obesity, weight loss, and sexual function...
April 26, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28454897/collagenase-clostridium-histolyticum-in-the-treatment-of-urologic-disease-current-and-future-impact
#16
REVIEW
Andrew T Gabrielson, Jonathan T Spitz, Wayne J G Hellstrom
INTRODUCTION: Peyronie's disease (PD) is a connective tissue disorder resulting in the abnormal accumulation of type I to III collagen, fibrin, and disorganized elastic fibers in the tunica albuginea of the penis. Many medical and non-pharmacologic modalities have been used in the treatment of PD; however, these approaches have proved largely ineffective, with surgery being the only definitive treatment. Intralesional injection of collagenase Clostridium histolyticum (CCH) has recently become the gold standard for minimally invasive treatment of PD, and studies have suggested the role of CCH could expand to the treatment of other urologic conditions such as urethral stricture disease...
April 25, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28446970/the-role-of-endobronchial-ultrasound-versus-mediastinoscopy-for-non-small-cell-lung-cancer
#17
REVIEW
Katarzyna Czarnecka-Kujawa, Kazuhiro Yasufuku
This review provides an update on the current role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and mediastinoscopy (Med) in assessment of patients with non-small cell lung cancer (NSCLC). Invasive mediastinal lymph node (LN) staging is the major application for both of these techniques. Up until recently, Med was the gold standard for invasive mediastinal LN staging in NSCLC. However, EBUS-TBNA has shown to be equivalent, and in some studies better than Med for invasive staging of lung cancer...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28430097/zika-virus-update-more-on-an-emerging-arboviral-disease-in-the-western-hemisphere
#18
Kelly G Vest
Zika virus has captivated the world with its quick spread throughout the Western Hemisphere. Increased emphasis has been placed on the infection of pregnant women and subsequent adverse and severe effects in the developing fetus and newborn. This article supplements a previous article and provides updated information on new and evolving evidence that strengthens the association between Zika virus and unique congenital and neurologic diseases, updates what is known about the epidemiology of the disease, and provides new and updated material for primary care providers as they counsel patients who may be exposed or infected...
April 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28325535/age-is-just-a-number-wpath-affiliated-surgeons-experiences-and-attitudes-toward-vaginoplasty-in-transgender-females-under-18-years-of-age-in-the-united-states
#19
Christine Milrod, Dan H Karasic
BACKGROUND: A rising number of female-affirmed transgender adolescents are being treated with gonadotropin-releasing hormone analogues and subsequently cross-sex hormones at early or mid-puberty, with vaginoplasty as the presumed final step in their physical transition. But, despite the minimum age of 18 years defining eligibility to undergo this irreversible procedure, anecdotal reports have shown that vaginoplasties are being performed on minors by surgeons in the United States, thereby contravening the World Professional Association for Transgender Health (WPATH) standards of care (SOC)...
April 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28208147/perspectives-on-speech-timing-coupled-oscillator-modeling-of-polish-and-finnish
#20
Zofia Malisz, Michael O'Dell, Tommi Nieminen, Petra Wagner
This stud y was ai med at analyzing empirical duration data for Polish spoken at different tempos using an updated version of the Coupled Oscillator Model of speech timing and rhythm variability (O'Dell and Nieminen, 1999, 2009). We use Bayesian inference on parameters relating to speech rate to investigate how tempo affects timing in Polish. The model parameters found are then compared with parameters obtained for equivalent material in Finnish to shed light on which of the effects represent general speech rate mechanisms and which are specific to Polish...
2016: Phonetica
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