Read by QxMD icon Read

med update

Ying-Shui Yao, Wei-Wei Chang, Lian-Ping He, Yue-Long Jin, Chao-Pin Li
The association between TGF-β1 polymorphisms and asthma risk has been widely reported, but results were controversial. We performed this meta-analysis based on the Preferred Reporting Items for Systematic Reviews and meta-analyses statement (PRISMA). Electronic database of Pub Med, Web of Science, CBM, and CNKI were searched for eligible articles published up to September, 2013. The effect summary odds ratio (OR) and 95% confidence intervals were obtained. Finally, a total of 20 articles were identified, 17 studies with 3694 cases and 5613 controls for C-509T polymorphism, 7 studies with 1109 cases and 1098 controls for T869C polymorphism and 5 studies with 849 cases and 829 controls for G915C polymorphism...
October 4, 2016: Human Immunology
J J Mark Haverkort, Jos H Bouman, Jelte D D Wind, Luke P H Leenen
OBJECTIVE: To describe the development of the Patient Barcode Registration System (PBRS) over time and confirm the usability and feasibility of the system's latest version during a large trauma drill. METHODS: The development of a PBRS started around 1993 aiming to provide an effective tool for patient registration, tracking, and tracing during major incidents. The PBRS uses wristbands with barcodes to follow and register patients in the care process. During a large trauma drill, 120 patients and 40 relatives were registered and traced in the system...
September 13, 2016: Disaster Medicine and Public Health Preparedness
Liang E Liu, Meaghan Dehning, Ashley Phipps, Ray E Swienton, Curtis A Harris, Kelly R Klein
OBJECTIVE: Mosquito-borne diseases pose a threat to individual health and population health on both a local and a global level. The threat is even more exaggerated during disasters, whether manmade or environmental. With the recent Zika virus outbreak, it is important to highlight other infections that can mimic the Zika virus and to better understand what can be done as public health officials and health care providers. METHODS: This article reviews the recent literature on the Zika virus as well as chikungunya virus and dengue virus...
August 30, 2016: Disaster Medicine and Public Health Preparedness
Jennifer Roggenbuck, Adam Quick, Stephen J Kolb
Patients with amyotrophic lateral sclerosis (ALS) often have questions about why they developed the disease and the likelihood that family members will also be affected. In recent years, providing answers to these questions has become more complex with the identification of multiple novel genes, the newly recognized etiologic link between ALS and frontotemporal dementia (FTD), and the increased availability of commercial genetic testing. A genetic diagnosis is particularly important to establish in the era of emerging gene-based therapies, such as SOD1 antisense oligonucleotide trials...
August 18, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Jeffrey M Sobell
Emerging data describe new potential indications for tumor necrosis factor (TNF) inhibitors in dermatology, including pediatric psoriasis and hidradenitis suppurativa. New biosimilar TNF agents are in late stages of development and may be available in the United States in the near future. Biosimilar agents are similar but not identical to available TNF inhibitors, and approval requires extensive analytic, toxicity, pharmacokinetic, pharmacodynamic, and clinical testing. Semin Cutan Med Surg 35(supp6):S104-S106...
June 2016: Seminars in Cutaneous Medicine and Surgery
Francisco A Kerdel
The introduction of tumor necrosis factor (TNF)-α inhibitors dramatically improved the management of psoriasis. Some newer or investigational biologics with different mechanisms of action have demonstrated noninferiority or superiority to etanercept, the first self-injectable anti-TNF-α agent to become available in the United States. Nonetheless, TNF-α inhibitors are likely to remain a mainstay of therapy for many years.
June 2016: Seminars in Cutaneous Medicine and Surgery
Eric L Simpson, Alan D Irvine, Lawrence F Eichenfield, Sheila F Friedlander
Studies of the prevalence of atopic dermatitis (AD) have provided insights into associated environmental risk factors, demonstrating the complex interactions between the presence of filaggrin (FLG) gene defects and environment. Among other important findings is that elevated transepidermal water loss (TEWL) in newborns is a strong predictor of AD, regardless of FLG status. Recently recognized predictors of disease course and severity include onset of AD signs and symptoms before 12 months of age and the presence of an FLG mutation and concomitant immunoglobulin E sensitization early in life...
June 2016: Seminars in Cutaneous Medicine and Surgery
Zhangxuan Hu, Xiaodong Ma, Trong-Kha Truong, Allen W Song, Hua Guo
PURPOSE: Either SENSE+CG or POCS-ICE methods can be used to correct for motion-induced phase errors in navigator-free multishot diffusion imaging. SENSE+CG has the advantage of a fast convergence, however, occasionally the convergence can be unstable, thus degrading the image quality. POCS-ICE has a stable convergence and can be used with a high number of shots, but its convergence is slow, which limits its practical usage. The study here proposes an improved method based on both SENSE+CG and POCS-ICE, called Phase-updated Regularized SENSE (PR-SENSE), for navigator-free multishot diffusion imaging...
August 13, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Benedetta Persechino, Luca Fontana, Giuliana Buresti, Bruna Maria Rondinone, Patrizia Laurano, Marcello Imbriani, Sergio Iavicoli
OBJECTIVES: Occupational medicine is a discipline continually evolving in response to technological advances, changes in workplaces and production processes, emergence of new occupational risks and diseases and modifications in regulatory framework for occupational health and safety. Therefore, the recurrent revaluation of professional activity, information demands and education and training needs of occupational physicians is essential in order to identify methodologies and tools that may contribute to improvement of their professional knowledge and competency...
2016: International Journal of Occupational Medicine and Environmental Health
Bruno De Man, Jorge Uribe, Jongduk Baek, Dan Harrison, Zhye Yin, Randy Longtin, Jaydeep Roy, Bill Waters, Colin Wilson, Jonathan Short, Lou Inzinna, Joseph Reynolds, V Bogdan Neculaes, Kristopher Frutschy, Bob Senzig, Norbert Pelc
PURPOSE: This paper presents an overview of multisource inverse-geometry computed tomography (IGCT) as well as the development of a gantry-based research prototype system. The development of the distributed x-ray source is covered in a companion paper [V. B. Neculaes et al., "Multisource inverse-geometry CT. Part II. X-ray source design and prototype," Med. Phys. 43, 4617-4627 (2016)]. While progress updates of this development have been presented at conferences and in journal papers, this paper is the first comprehensive overview of the multisource inverse-geometry CT concept and prototype...
August 2016: Medical Physics
Anthony R Gregg, Brian G Skotko, Judith L Benkendorf, Kristin G Monaghan, Komal Bajaj, Robert G Best, Susan Klugman, Michael S Watson
This statement is designed primarily as an educational resource for clinicians to help them provide quality medical services. Adherence to this statement is completely voluntary and does not necessarily assure a successful medical outcome. This statement should not be considered inclusive of all proper procedures and tests or exclusive of other procedures and tests that are reasonably directed toward obtaining the same results. In determining the propriety of any specific procedure or test, the clinician should apply his or her own professional judgment to the specific clinical circumstances presented by the individual patient or specimen...
October 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Ping Sun, Wei-Qi Song
AIM OF STUDY: To clarify the effects of glutathione S-transferases mu-1. (GSTM1) null genotype on the risk of CC, an updated meta-analysis. was performed in Chinese populations. MATERIALS AND METHODS: An extensive literature search for relevant studies was conducted on Pub Med, Springer Link, Ovid SP, Chinese Biomedical (CBM), Chinese National Knowledge Infrastructure (CNKI), VIP, and Wan fang Database from their inception through 22 October, 2014. This meta-analysis was performed using the STATA 10...
April 2016: Journal of Cancer Research and Therapeutics
Melinda J Morton Hamer, John J Jordan, Paul L Reed, Jane D Greulich, Dame B Gaye, Charles W Beadling
OBJECTIVE: The Republic of Senegal Disaster Preparedness and Response Exercise was held from June 2-6, 2014, in Dakar, Senegal. The goal was to assist in familiarizing roles and responsibilities within 3 existing plans and to update the National Disaster Management Strategic Work Plan. METHODS: There were 60 participants in the exercise, which was driven by a series of evolving disaster scenarios. During the separate Disaster Management Strategic Work Plan review, participants refined a list of projects, including specific tasks to provide a "road map" for completing each project, project timelines, and estimated resource requirements...
July 27, 2016: Disaster Medicine and Public Health Preparedness
Garry M Walsh
INTRODUCTION: The development of monoclonal antibody-based biologics targeted at inhibition of the Th2 cytokines IL-4, IL-5 and IL-13 represent potentially effective treatments for patients with the glucocorticoid refractory eosinophilic asthma phenotype. AREAS COVERED: Asthma exhibits marked heterogeneity both clinically and at the molecular phenotypic level, requiring specifically targeted treatments to block the key pathways of the disease. It is becoming apparent that significant clinical effects with anti-cytokine-based biologic therapies are more likely in carefully selected patient populations that take asthma phenotypes into account...
August 2, 2016: Expert Review of Clinical Immunology
Stephen J Bertke, Everett J Lehman, Steven J Wurzelbacher, Misty J Hein
BACKGROUND: Lead exposure has been linked to impaired renal function and kidney failure. High lead exposures have been associated with increased mortality from certain cancers, hypertension, cardiovascular disease, and amyotrophic lateral sclerosis (ALS). METHODS: We extended vital status follow-up on a cohort of 1,990 lead smelter workers by 25 years and computed standardized mortality ratios and rate ratios (RR) stratified by cumulative lead exposure. RESULTS: The update added 13,823 person-years at risk and 721 deaths...
June 28, 2016: American Journal of Industrial Medicine
Lynne E Pinkerton, James H Yiin, Robert D Daniels, Kenneth W Fent
BACKGROUND: Mortality among 4,545 toluene diisocyante (TDI)-exposed workers was updated through 2011. The primary outcome of interest was lung cancer. METHODS: Life table analyses, including internal analyses by exposure duration and cumulative TDI exposure, were conducted. RESULTS: Compared with the US population, all cause and all cancer mortality was increased. Lung cancer mortality was increased but was not associated with exposure duration or cumulative TDI exposure...
August 2016: American Journal of Industrial Medicine
Lainie Rutkow, Alexandra Jabs
OBJECTIVE: We sought to systematically identify and analyze state-level legislative responses to Ebola from April 2014 through June 2015. METHODS: Using standardized search terms, we searched the LexisNexis State Capital database to identify bills or resolutions that explicitly mentioned Ebola or viral hemorrhagic fever in all 50 US states and Washington, DC, from April 2014 through June 2015. Information was abstracted from relevant bills or resolutions by using an electronic data collection form...
August 2016: Disaster Medicine and Public Health Preparedness
Kathleen P Tebb, Rebecca K Erenrich, Carolyn Bradner Jasik, Mark S Berna, James C Lester, Elizabeth M Ozer
BACKGROUND: Alcohol use and binge drinking among adolescents and young adults remain frequent causes of preventable injuries, disease, and death, and there has been growing attention to computer-based modes of intervention delivery to prevent/reduce alcohol use. Research suggests that health interventions grounded in established theory are more effective than those with no theoretical basis. The goal of this study was to conduct a literature review of computer-based interventions (CBIs) designed to address alcohol use among adolescents and young adults (aged 12-21 years) and examine the extent to which CBIs use theories of behavior change in their development and evaluations...
2016: BMC Public Health
Wei Yu, Marta Gwinn, W David Dotson, Ridgely Fisk Green, Mindy Clyne, Anja Wulf, Scott Bowen, Katherine Kolor, Muin J Khoury
PURPOSE: We created an online knowledge base (the Public Health Genomics Knowledge Base (PHGKB)) to provide systematically curated and updated information that bridges population-based research on genomics with clinical and public health applications. METHODS: Weekly horizon scanning of a wide variety of online resources is used to retrieve relevant scientific publications, guidelines, and commentaries. After curation by domain experts, links are deposited into Web-based databases...
June 9, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Peter A Clem, Pooshan D Navathe, Michael A Drane
BACKGROUND: In 2012 the Australian Institute of Health and Welfare produced a report titled 'Dementia in Australia.'(2) The report noted that the number of people with dementia in Australia would reach almost 400,000 by 2020. Australia is a jurisdiction which does not impose a mandatory retirement age for pilots. With an aging population it was hypothesized that conditions such as Parkinson's disease (PD) were likely to be seen more commonly by the Civil Aviation Safety Authority (CASA)...
June 2016: Aerospace Medicine and Human Performance
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"