keyword
https://read.qxmd.com/read/31316554/single-locus-and-multi-locus-genome-wide-association-studies-for-intramuscular-fat-in-duroc-pigs
#21
JOURNAL ARTICLE
Rongrong Ding, Ming Yang, Jianping Quan, Shaoyun Li, Zhanwei Zhuang, Shenping Zhou, Enqin Zheng, Linjun Hong, Zicong Li, Gengyuan Cai, Wen Huang, Zhenfang Wu, Jie Yang
Intramuscular fat (IMF) is an important quantitative trait of meat, which affects the associated sensory properties and nutritional value of pork. To gain a better understanding of the genetic determinants of IMF, we used a composite strategy, including single-locus and multi-locus association analyses to perform genome-wide association studies (GWAS) for IMF in 1,490 Duroc boars. We estimated the genomic heritability of IMF to be 0.23 ± 0.04. A total of 30 single nucleotide polymorphisms (SNPs) were found to be significantly associated with IMF...
2019: Frontiers in Genetics
https://read.qxmd.com/read/30531019/association-of-gtf2ird1-gtf2i-polymorphisms-with-neuromyelitis-optica-spectrum-disorders-in-han-chinese-patients
#22
JOURNAL ARTICLE
Jing-Lu Xie, Ju Liu, Zhi-Yun Lian, Hong-Xi Chen, Zi-Yan Shi, Qin Zhang, Hui-Ru Feng, Qin Du, Xiao-Hui Miao, Hong-Yu Zhou
Variants at the GTF2I repeat domain containing 1 (GTF2IRD1)-GTF2I locus are associated with primary Sjögren's syndrome, systemic lupus erythematosus, and rheumatoid arthritis. Numerous studies have indicated that this susceptibility locus is shared by multiple autoimmune diseases. However, until now there were no studies of the correlation between GTF2IRD1-GTF2I polymorphisms and neuromyelitis optica spectrum disorders (NMOSD). This case control study assessed this association by recruiting 305 participants with neuromyelitis optica spectrum disorders and 487 healthy controls at the Department of Neurology, from September 2014 to April 2017...
February 2019: Neural Regeneration Research
https://read.qxmd.com/read/30008175/exome-sequencing-of-85-williams-beuren-syndrome-cases-rules-out-coding-variation-as-a-major-contributor-to-remaining-variance-in-social-behavior
#23
JOURNAL ARTICLE
Nathan D Kopp, Phoebe C R Parrish, Michael Lugo, Joseph D Dougherty, Beth A Kozel
BACKGROUND: Large, multigenic deletions at chromosome 7q11.23 result in a highly penetrant constellation of physical and behavioral symptoms known as Williams-Beuren syndrome (WS). Of particular interest is the unusual social-cognitive profile evidenced by deficits in social cognition and communication reminiscent of autism spectrum disorders (ASD) that are juxtaposed with normal or even relatively enhanced social motivation. Interestingly, duplications in the same region also result in ASD-like phenotypes as well as social phobias...
September 2018: Molecular Genetics & Genomic Medicine
https://read.qxmd.com/read/29884845/williams-syndrome-neuroanatomical-score-associates-with-gtf2ird1-in-large-scale-magnetic-resonance-imaging-cohorts-a-proof-of-concept-for-multivariate-endophenotypes
#24
JOURNAL ARTICLE
Chun Chieh Fan, Andrew J Schork, Timothy T Brown, Barbara E Spencer, Natacha Akshoomoff, Chi-Hua Chen, Joshua M Kuperman, Donald J Hagler, Vidar M Steen, Stephanie Le Hellard, Asta Kristine Håberg, Thomas Espeseth, Ole A Andreassen, Anders M Dale, Terry L Jernigan, Eric Halgren
Despite great interest in using magnetic resonance imaging (MRI) for studying the effects of genes on brain structure in humans, current approaches have focused almost entirely on predefined regions of interest and had limited success. Here, we used multivariate methods to define a single neuroanatomical score of how William's Syndrome (WS) brains deviate structurally from controls. The score is trained and validated on measures of T1 structural brain imaging in two WS cohorts (training, n = 38; validating, n = 60)...
June 8, 2018: Translational Psychiatry
https://read.qxmd.com/read/29400567/regulatory-network-analysis-of-hypertension-and-hypotension-microarray-data-from-mouse-model
#25
JOURNAL ARTICLE
Yanli Zhu, Jingming Zhuo, Chunmei Li, Qian Wang, Xuefei Liu, Lin Ye
We aimed to identify the potential genes related to blood pressure regulation and screen target genes for high blood pressure (BPH) and low blood pressure (BPL) treatment. The GSE19817 microarray dataset, which included the aorta, liver, heart, and kidney samples from BPH, BPL, and normotensive mice, was downloaded from the Gene Expression Omnibus. Principal component analysis (PCA) was performed based on the entire expression profile. Differentially expressed genes (DEGs) were screened, followed by pathway enrichment analysis...
2018: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/29320702/repression-of-adipose-tissue-fibrosis-through-a-prdm16-gtf2ird1-complex-improves-systemic-glucose-homeostasis
#26
JOURNAL ARTICLE
Yutaka Hasegawa, Kenji Ikeda, Yong Chen, Diana L Alba, Daniel Stifler, Kosaku Shinoda, Takashi Hosono, Pema Maretich, Yangyu Yang, Yasushi Ishigaki, Jingyi Chi, Paul Cohen, Suneil K Koliwad, Shingo Kajimura
Adipose tissue fibrosis is a hallmark of malfunction that is linked to insulin resistance and type 2 diabetes; however, what regulates this process remains unclear. Here we show that the PRDM16 transcriptional complex, a dominant activator of brown/beige adipocyte development, potently represses adipose tissue fibrosis in an uncoupling protein 1 (UCP1)-independent manner. By purifying the PRDM16 complex, we identified GTF2IRD1, a member of the TFII-I family of DNA-binding proteins, as a cold-inducible transcription factor that mediates the repressive action of the PRDM16 complex on fibrosis...
January 9, 2018: Cell Metabolism
https://read.qxmd.com/read/28776031/structural-variants-in-genes-associated-with-human-williams-beuren-syndrome-underlie-stereotypical-hypersociability-in-domestic-dogs
#27
JOURNAL ARTICLE
Bridgett M vonHoldt, Emily Shuldiner, Ilana Janowitz Koch, Rebecca Y Kartzinel, Andrew Hogan, Lauren Brubaker, Shelby Wanser, Daniel Stahler, Clive D L Wynne, Elaine A Ostrander, Janet S Sinsheimer, Monique A R Udell
Although considerable progress has been made in understanding the genetic basis of morphologic traits (for example, body size and coat color) in dogs and wolves, the genetic basis of their behavioral divergence is poorly understood. An integrative approach using both behavioral and genetic data is required to understand the molecular underpinnings of the various behavioral characteristics associated with domestication. We analyze a 5-Mb genomic region on chromosome 6 previously found to be under positive selection in domestic dog breeds...
July 2017: Science Advances
https://read.qxmd.com/read/28135245/a-missense-variant-in-ncf1-is-associated-with-susceptibility-to-multiple-autoimmune-diseases
#28
JOURNAL ARTICLE
Jian Zhao, Jianyang Ma, Yun Deng, Jennifer A Kelly, Kwangwoo Kim, So-Young Bang, Hye-Soon Lee, Quan-Zhen Li, Edward K Wakeland, Rong Qiu, Mengru Liu, Jianping Guo, Zhanguo Li, Wenfeng Tan, Astrid Rasmussen, Christopher J Lessard, Kathy L Sivils, Bevra H Hahn, Jennifer M Grossman, Diane L Kamen, Gary S Gilkeson, Sang-Cheol Bae, Patrick M Gaffney, Nan Shen, Betty P Tsao
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with a strong genetic component characterized by autoantibody production and a type I interferon signature. Here we report a missense variant (g.74779296G>A; p.Arg90His) in NCF1, encoding the p47phox subunit of the phagocyte NADPH oxidase (NOX2), as the putative underlying causal variant that drives a strong SLE-associated signal detected by the Immunochip in the GTF2IRD1-GTF2I region at 7q11.23 with a complex genomic structure. We show that the p...
March 2017: Nature Genetics
https://read.qxmd.com/read/27295951/rna-seq-analysis-of-gtf2ird1-knockout-epidermal-tissue-provides-potential-insights-into-molecular-mechanisms-underpinning-williams-beuren-syndrome
#29
JOURNAL ARTICLE
Susan M Corley, Cesar P Canales, Paulina Carmona-Mora, Veronica Mendoza-Reinosa, Annemiek Beverdam, Edna C Hardeman, Marc R Wilkins, Stephen J Palmer
BACKGROUND: Williams-Beuren Syndrome (WBS) is a genetic disorder associated with multisystemic abnormalities, including craniofacial dysmorphology and cognitive defects. It is caused by a hemizygous microdeletion involving up to 28 genes in chromosome 7q11.23. Genotype/phenotype analysis of atypical microdeletions implicates two evolutionary-related transcription factors, GTF2I and GTF2IRD1, as prime candidates for the cause of the facial dysmorphology. RESULTS: Using a targeted Gtf2ird1 knockout mouse, we employed massively-parallel sequencing of mRNA (RNA-Seq) to understand changes in the transcriptional landscape associated with inactivation of Gtf2ird1 in lip tissue...
June 13, 2016: BMC Genomics
https://read.qxmd.com/read/27239038/an-in%C3%A2-vivo-gain-of-function-screen-identifies-the-williams-beuren-syndrome-gene-gtf2ird1-as-a-mammary-tumor-promoter
#30
JOURNAL ARTICLE
Yongliang Huo, Timothy Su, Qiuyin Cai, Ian G Macara
The broad implementation of precision medicine in cancer is impeded by the lack of a complete inventory of the genes involved in tumorigenesis. We performed in vivo screening of ∼1,000 genes that are associated with signaling for positive roles in breast cancer, using lentiviral expression vectors in primary MMTV-ErbB2 mammary tissue. Gain of function of five genes, including RET, GTF2IRD1, ADORA1, LARS2, and DPP8, significantly promoted mammary tumor growth. We further studied one tumor-promoting gene, the transcription factor GTF2IRD1...
June 7, 2016: Cell Reports
https://read.qxmd.com/read/26884464/gtf2ird1-dependent-mohawk-expression-regulates-mechanosensing-properties-of-the-tendon
#31
JOURNAL ARTICLE
Tomohiro Kayama, Masaki Mori, Yoshiaki Ito, Takahide Matsushima, Ryo Nakamichi, Hidetsugu Suzuki, Shizuko Ichinose, Mitsuru Saito, Keishi Marumo, Hiroshi Asahara
Mechanoforces experienced by an organ are translated into biological information for cellular sensing and response. In mammals, the tendon connective tissue experiences and resists physical forces, with tendon-specific mesenchymal cells called tenocytes orchestrating extracellular matrix (ECM) turnover. We show that Mohawk (Mkx), a tendon-specific transcription factor, is essential in mechanoresponsive tenogenesis through regulation of its downstream ECM genes such as type I collagens and proteoglycans such as fibromodulin both in vivo and in vitro Wild-type (WT) mice demonstrated an increase in collagen fiber diameter and density in response to physical treadmill exercise, whereas in Mkx(-/-) mice, tendons failed to respond to the same mechanical stimulation...
April 2016: Molecular and Cellular Biology
https://read.qxmd.com/read/26808113/high-density-genotyping-of-immune-related-loci-identifies-new-sle-risk-variants-in-individuals-with-asian-ancestry
#32
JOURNAL ARTICLE
Celi Sun, Julio E Molineros, Loren L Looger, Xu-Jie Zhou, Kwangwoo Kim, Yukinori Okada, Jianyang Ma, Yuan-Yuan Qi, Xana Kim-Howard, Prasenjeet Motghare, Krishna Bhattarai, Adam Adler, So-Young Bang, Hye-Soon Lee, Tae-Hwan Kim, Young Mo Kang, Chang-Hee Suh, Won Tae Chung, Yong-Beom Park, Jung-Yoon Choe, Seung Cheol Shim, Yuta Kochi, Akari Suzuki, Michiaki Kubo, Takayuki Sumida, Kazuhiko Yamamoto, Shin-Seok Lee, Young Jin Kim, Bok-Ghee Han, Mikhail Dozmorov, Kenneth M Kaufman, Jonathan D Wren, John B Harley, Nan Shen, Kek Heng Chua, Hong Zhang, Sang-Cheol Bae, Swapan K Nath
Systemic lupus erythematosus (SLE) has a strong but incompletely understood genetic architecture. We conducted an association study with replication in 4,478 SLE cases and 12,656 controls from six East Asian cohorts to identify new SLE susceptibility loci and better localize known loci. We identified ten new loci and confirmed 20 known loci with genome-wide significance. Among the new loci, the most significant locus was GTF2IRD1-GTF2I at 7q11.23 (rs73366469, Pmeta = 3.75 × 10(-117), odds ratio (OR) = 2.38), followed by DEF6, IL12B, TCF7, TERT, CD226, PCNXL3, RASGRP1, SYNGR1 and SIGLEC6...
March 2016: Nature Genetics
https://read.qxmd.com/read/26508570/de-novo-variants-in-sporadic-cases-of-childhood-onset-schizophrenia
#33
JOURNAL ARTICLE
Amirthagowri Ambalavanan, Simon L Girard, Kwangmi Ahn, Sirui Zhou, Alexandre Dionne-Laporte, Dan Spiegelman, Cynthia V Bourassa, Julie Gauthier, Fadi F Hamdan, Lan Xiong, Patrick A Dion, Ridha Joober, Judith Rapoport, Guy A Rouleau
Childhood-onset schizophrenia (COS), defined by the onset of illness before age 13 years, is a rare severe neurodevelopmental disorder of unknown etiology. Recently, sequencing studies have identified rare, potentially causative de novo variants in sporadic cases of adult-onset schizophrenia and autism. In this study, we performed exome sequencing of 17 COS trios in order to test whether de novo variants could contribute to this disease. We identified 20 de novo variants in 17 COS probands, which is consistent with the de novo mutation rate reported in the adult form of the disease...
June 2016: European Journal of Human Genetics: EJHG
https://read.qxmd.com/read/26320362/association-of-gtf2i-and-gtf2ird1-polymorphisms-with-systemic-lupus-erythematosus-in-a-chinese-han-population
#34
JOURNAL ARTICLE
Yuan Li, Ping Li, Si Chen, Ziyan Wu, Jing Li, Shulan Zhang, Chunwei Cao, Li Wang, Bin Liu, Fengchun Zhang, Yong Zhe Li
OBJECTIVES: Systemic lupus erythematosus (SLE) is the most common systemic autoimmune disease which likely involves complex interactions between genes and the environment. Two large-scale genome-wide association studies (GWAS) have implicated many loci as genetic risk factors associated with primary Sjögren's syndrome (pSS). Among them there are a number of pSS associated gene polymorphisms including the MHC-II, STAT4, IRF5, BLK, and TNIP1 genes that are shared with SLE. However, the association of other genes such as GTF2I, GTF2IRD1, and IL12A with SLE remain unknown...
September 2015: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/26275350/the-nuclear-localization-pattern-and-interaction-partners-of-gtf2ird1-demonstrate-a-role-in-chromatin-regulation
#35
JOURNAL ARTICLE
Paulina Carmona-Mora, Jocelyn Widagdo, Florence Tomasetig, Cesar P Canales, Yeojoon Cha, Wei Lee, Abdullah Alshawaf, Mirella Dottori, Renee M Whan, Edna C Hardeman, Stephen J Palmer
GTF2IRD1 is one of the three members of the GTF2I gene family, clustered on chromosome 7 within a 1.8 Mb region that is prone to duplications and deletions in humans. Hemizygous deletions cause Williams-Beuren syndrome (WBS) and duplications cause WBS duplication syndrome. These copy number variations disturb a variety of developmental systems and neurological functions. Human mapping data and analyses of knockout mice show that GTF2IRD1 and GTF2I underpin the craniofacial abnormalities, mental retardation, visuospatial deficits and hypersociability of WBS...
October 2015: Human Genetics
https://read.qxmd.com/read/25392503/the-transcription-factor-gtf2ird1-regulates-the-topology-and-function-of-photoreceptors-by-modulating-photoreceptor-gene-expression-across-the-retina
#36
JOURNAL ARTICLE
Tomohiro Masuda, Xiaodong Zhang, Cindy Berlinicke, Jun Wan, Anitha Yerrabelli, Elizabeth A Conner, Sten Kjellstrom, Ronald Bush, Snorri S Thorgeirsson, Anand Swaroop, Shiming Chen, Donald J Zack
The mechanisms that specify photoreceptor cell-fate determination, especially as regards to short-wave-sensitive (S) versus medium-wave-sensitive (M) cone identity, and maintain their nature and function, are not fully understood. Here we report the importance of general transcription factor II-I repeat domain-containing protein 1 (GTF2IRD1) in maintaining M cone cell identity and function as well as rod function. In the mouse, GTF2IRD1 is expressed in cell-fate determined photoreceptors at postnatal day 10...
November 12, 2014: Journal of Neuroscience
https://read.qxmd.com/read/25248400/the-role-of-gtf2ird1-in-the-auditory-pathology-of-williams-beuren-syndrome
#37
JOURNAL ARTICLE
Cesar P Canales, Ann C Y Wong, Peter W Gunning, Gary D Housley, Edna C Hardeman, Stephen J Palmer
Williams-Beuren Syndrome (WBS) is a rare genetic condition caused by a hemizygous deletion involving up to 28 genes within chromosome 7q11.23. Among the spectrum of physical and neurological defects in WBS, it is common to find a distinctive response to sound stimuli that includes extreme adverse reactions to loud, or sudden sounds and a fascination with certain sounds that may manifest as strengths in musical ability. However, hearing tests indicate that sensorineural hearing loss (SNHL) is frequently found in WBS patients...
June 2015: European Journal of Human Genetics: EJHG
https://read.qxmd.com/read/25105779/mapping-genetically-controlled-neural-circuits-of-social-behavior-and-visuo-motor-integration-by-a-preliminary-examination-of-atypical-deletions-with-williams-syndrome
#38
JOURNAL ARTICLE
Fumiko Hoeft, Li Dai, Brian W Haas, Kristen Sheau, Masaru Mimura, Debra Mills, Albert Galaburda, Ursula Bellugi, Julie R Korenberg, Allan L Reiss
In this study of eight rare atypical deletion cases with Williams-Beuren syndrome (WS; also known as 7q11.23 deletion syndrome) consisting of three different patterns of deletions, compared to typical WS and typically developing (TD) individuals, we show preliminary evidence of dissociable genetic contributions to brain structure and human cognition. Univariate and multivariate pattern classification results of morphometric brain patterns complemented by behavior implicate a possible role for the chromosomal region that includes: 1) GTF2I/GTF2IRD1 in visuo-spatial/motor integration, intraparietal as well as overall gray matter structures, 2) the region spanning ABHD11 through RFC2 including LIMK1, in social cognition, in particular approachability, as well as orbitofrontal, amygdala and fusiform anatomy, and 3) the regions including STX1A, and/or CYLN2 in overall white matter structure...
2014: PloS One
https://read.qxmd.com/read/25057328/genetic-contributions-to-visuospatial-cognition-in-williams-syndrome-insights-from-two-contrasting-partial-deletion-patients
#39
JOURNAL ARTICLE
Hannah Broadbent, Emily K Farran, Esther Chin, Kay Metcalfe, May Tassabehji, Peter Turnpenny, Francis Sansbury, Emma Meaburn, Annette Karmiloff-Smith
BACKGROUND: Williams syndrome (WS) is a rare neurodevelopmental disorder arising from a hemizygotic deletion of approximately 27 genes on chromosome 7, at locus 7q11.23. WS is characterised by an uneven cognitive profile, with serious deficits in visuospatial tasks in comparison to relatively proficient performance in some other cognitive domains such as language and face processing. Individuals with partial genetic deletions within the WS critical region (WSCR) have provided insights into the contribution of specific genes to this complex phenotype...
2014: Journal of Neurodevelopmental Disorders
https://read.qxmd.com/read/24097066/a-genome-wide-association-study-in-han-chinese-identifies-a-susceptibility-locus-for-primary-sj%C3%A3-gren-s-syndrome-at-7q11-23
#40
JOURNAL ARTICLE
Yongzhe Li, Kunlin Zhang, Hua Chen, Fei Sun, Juanjuan Xu, Ziyan Wu, Ping Li, Liuyan Zhang, Yang Du, Haixia Luan, Xi Li, Lijun Wu, Hongbin Li, Huaxiang Wu, Xiangpei Li, Xiaomei Li, Xiao Zhang, Lu Gong, Lie Dai, Lingyun Sun, Xiaoxia Zuo, Jianhua Xu, Huiping Gong, Zhijun Li, Shengquan Tong, Min Wu, Xiaofeng Li, Weiguo Xiao, Guochun Wang, Ping Zhu, Min Shen, Shengyun Liu, Dongbao Zhao, Wei Liu, Yi Wang, Cibo Huang, Quan Jiang, Guijian Liu, Bin Liu, Shaoxian Hu, Wen Zhang, Zhuoli Zhang, Xin You, Mengtao Li, Weixin Hao, Cheng Zhao, Xiaomei Leng, Liqi Bi, Yongfu Wang, Fengxiao Zhang, Qun Shi, Wencheng Qi, Xuewu Zhang, Yuan Jia, Jinmei Su, Qin Li, Yong Hou, Qingjun Wu, Dong Xu, Wenjie Zheng, Miaojia Zhang, Qian Wang, Yunyun Fei, Xuan Zhang, Jing Li, Ying Jiang, Xinping Tian, Lidan Zhao, Li Wang, Bin Zhou, Yang Li, Yan Zhao, Xiaofeng Zeng, Jurg Ott, Jing Wang, Fengchun Zhang
Primary Sjögren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of Sjögren's syndrome have relied mostly on candidate gene approaches. To identify new genetic susceptibility loci for primary Sjögren's syndrome, we performed a three-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 556,134 autosomal SNPs in 542 cases and 1,050 controls. We then validated promising associations in 2 replication stages comprising 1,303 cases and 2,727 controls...
November 2013: Nature Genetics
keyword
keyword
83575
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.