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Hypoparathyroid

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https://www.readbyqxmd.com/read/29767477/effect-of-neurological-monitoring-in-postoperative-5-15-days-residual-thyroidectomy-after-primary-thyroid-cancer-surgery
#1
Miao-Yun Long, Fei-Yu Diao, Li-Na Peng, Lang-Ping Tan, Yue Zhu, Kai Huang, Hong-Hao Li
AIM: To explore the application of intraoperative neurological monitoring in residual thyroidectomy 5-15 days after thyroid cancer operation and the influence on postoperative serum thyroglobulin (Tg), recurrent laryngeal nerve and function of parathyroid glands. METHODS: Material of patients receiving thyroid surgery from January 2010 to December 2016 was retrospectively analyzed. Cases meeting with standards were enrolled for analysis and the patients were divided into neurological monitoring group and non-neurological monitoring group in line with the use of neurological monitoring during the operation...
May 16, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29755708/growth-and-endocrine-function-in-tunisian-thalassemia-major-patients
#2
Naouel Guirat Dhouib, Monia Ben Khaled, Monia Ouederni, Habib Besbes, Ridha Kouki, Fethi Mellouli, Mohamed Bejaoui
β-thalassemia major (β-TM) is among the most common hereditary disorders imposing high expenses on health-care system worldwide. The patient's survival is dependent on lifetime blood transfusion which leads to iron overload and its toxicity in various organs including endocrine glands. This article provides an overview of endocrine disorders in beta-TM patients. This single center investigation enrolled 28 β-TM patients (16 males, 12 females) regularly transfused with packed red cell since early years of life...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29755522/in-situ-preservation-fraction-of-parathyroid-gland-in-thyroidectomy-a-cohort-retrospective-study
#3
Han Luo, Wanjun Zhao, Hongliu Yang, Anping Su, Bin Wang, Jingqiang Zhu
Background and Objectives: Parathyroid failure is the most common symptom after thyroidectomy. To prevent it, a gland was preserved in situ or an ischemic one was autotransplanted. This study explored the relationship between in situ preservation of the parathyroid gland and gland failure. Methods: Consecutive patients who underwent initial total thyroidectomy were enrolled retrospectively in a prospectively maintained database. Patients were divided into groups by parathyroid gland remaining in situ fraction (PGRIF) (PGRIF = number of in situ glands/(total number of identified glands - number of glands in specimen)...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29747960/postoperative-hypoparathyroidism-after-total-thyroidectomy-for-thyroid-cancer
#4
Masanori Teshima, Naoki Otsuki, Naruhiko Morita, Tatsuya Furukawa, Hitomi Shinomiya, Hirotaka Shinomiya, Ken-Ichi Nibu
OBJECTIVES: Postoperative hypoparathyroidism (HPT) is one of the most common complications in total thyroidectomy for thyroid carcinoma. Parathyroid glands (PTGs) are at risk of being damaged during total thyroidectomy and central neck dissection mainly due to inadvertent removal, interruption of the blood supply or hematoma formation. The purpose of this study was to evaluate the efficacy of our surgical procedure to preserve for parathyroid function retrospectively and to clarify the risk factors of HPT after total thyroidectomy for thyroid cancer...
May 7, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29726397/under-recognized-hypoparathyroidism-in-thalassemia
#5
Hataitip Tangngam, Pat Mahachoklertwattana, Preamrudee Poomthavorn, Ampaiwan Chuansumrit, Nongnuch Sirachainan, La-or Chailurkit, Patcharin Khlairit
OBJECTIVE: Symptomatic hypoparathyroidism [symptomatic hypocalcemia without elevated serum parathyroid hormone (PTH)] in patients with thalassemia is relatively rare. Asymptomatic mild hypocalcemia without elevated PTH which is considered hypoparathyroidism may be more common but under-recognized. METHODS: Sixty-six transfusion-dependent thalassemic patients, and 28 healthy controls were enrolled. Serum calcium (Ca), phosphate (P), creatinine (Cr), albumin, intact PTH, 25-hydroxyvitamin D (25-OHD), plasma intact fibroblast growth factor-23 (FGF-23), urine Ca, P and Cr were measured...
May 4, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29721546/surgical-approach-to-the-intrathoracic-goiter
#6
Michael Vaiman, Inessa Bekerman, Jabarin Basel, Michael Peer
Objective: In a retrospective study, the authors analyzed the surgical approach to the intrathoracic goiter to avoid sternotomy or thoracotomy. Methods: We selected 70 intrathoracic cases of multinodular goiter out of 988 cases of thyroidectomy and compared them with cervical goiter cases. Surgical technique, results, and postsurgical complications were assessed. Results: The analyzed cases presented the retrosternal goiter (n = 53; 75...
April 2018: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29712601/central-lymph-node-dissection-improves-lymph-node-clearance-in-papillary-thyroid-cancer-patients-with-lateral-neck-metastases-even-after-prior-total-thyroidectomy
#7
Chad M Hall, Samuel K Snyder, Terry C Lairmore
The oncologic benefit of a central lymph node dissection (CLND) at the time of modified radical neck dissection (MRND) in patients with papillary thyroid cancer who have previously undergone a total thyroidectomy (TT) has not been studied. Patients with lateral cervical metastases were divided into two treatment groups: the concurrent cohort (TT with CLND and MRND), and the interval cohort (CLND and MRND after prior TT). Primary outcomes were lymph node metastases, skip metastases, level VI cancer recurrence, hypoparathyroidism and recurrent laryngeal nerve injury...
April 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29709532/-severe-hypercalcemia-of-unusual-cause-looking-for-the-culprit-case-report-and-review-of-the-literature
#8
M Jalbert, A Mignot, A-S Gauchez, A-C Dobrokhotov, J Fourcade
INTRODUCTION: Hypercalcemia is not a rare event and can lead to severe consequences. Its main etiologies are primary hyperparathyroidism and neoplasic conditions. The iatrogenic etiology by vitamin D intoxication is more rarely found. CASE PRESENTATION: A 76-year-old finish woman comes to the emergency room for chest pain. Her medical history is impossible to specify due to the language barrier and initial confusion. She has severe hypercalcaemia (4.14mmol/L), renal insufficiency, cardiac arrhythmia later complicated by an ischemic cardiac episode...
April 27, 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29697378/surgical-prevention-and-treatment-of-postoperative-hypoparathyroidism-in-patients-operated-on-thyroid-gland
#9
V Skrypko, A Pasko, I Churpiy, A Kovalenko, V Zaplutanov
The objective of the research was to develop and evaluate the algorithm of prevention and treatment of postoperative hypoparathyroidism (PHPT) based on determining parathyroid glands (PTG) viability and the use of antihypoxant-antioxidant therapy in the postoperative period. The research was based on the results of a comprehensive examination and treatment of 60 patients who were operated for thyroid gland diseases. The patients underwent inpatient treatment at the surgical department of Ivano-Frankivsk Central City Clinical Hospital and Ivano-Frankivsk Regional Oncology Center from 2015 to 2017...
March 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29694629/diagnosis-and-treatment-of-hypoparathyroidism-a-position-statement-from-the-brazilian-society-of-endocrinology-and-metabolism
#10
Sergio Setsuo Maeda, Carolina Aguiar Moreira, Victória Zeghbi Cochenski Borba, Francisco Bandeira, Maria Lucia Fleiuss de Farias, João Lindolfo Cunha Borges, Francisco José Albuquerque de Paula, Felipe Augusto Brasileiro Vanderlei, Fábio Luiz de Menezes Montenegro, Rodrigo Oliveira Santos, Bruno Ferraz-de-Souza, Marise Lazaretti-Castro
Objective To present an update on the diagnosis and treatment of hypoparathyroidism based on the most recent scientific evidence. Materials and methods The Department of Bone and Mineral Metabolism of the Sociedade Brasileira de Endocrinologia e Metabologia (SBEM; Brazilian Society of Endocrinology and Metabolism) was invited to prepare a document following the rules set by the Guidelines Program of the Associação Médica Brasileira (AMB; Brazilian Medical Association). Relevant papers were retrieved from the databases MEDLINE/PubMed, LILACS, and SciELO, and the evidence derived from each article was classified into recommendation levels according to scientific strength and study type...
February 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29685599/hypoparathyroidism-in-total-thyroidectomy-due-to-benign-thyroid-diseases
#11
Burak Ertaş, Bayram Veyseller, Abdullah Karataş, Alper Özdilek, Remzi Doğan, Orhan Ozturan
PURPOSE: Our aim was to compare the effects of exposing the recurrent laryngeal nerve throughout its entire course with exposing the nerve only at its entry to the larynx in patients undergoing total thyroidectomy due to benign thyroid diseases, and to evaluate the effects of these methods on the risk for hypoparathyroidism. METHODS: The medical records of 437 patients who had undergone total thyroidectomy at the ear, nose, and throat clinic between 2001 and 2015 for benign thyroid diseases were evaluated retrospectively...
April 20, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29680147/discovery-and-development-of-calcimimetic-and-calcilytic-compounds
#12
Edward F Nemeth, Bradford C Van Wagenen, Manuel F Balandrin
The extracellular calcium receptor (CaR) is a G protein-coupled receptor (GPCR) and the pivotal molecule regulating systemic Ca2+ homeostasis. The CaR was a challenging target for drug discovery because its physiological ligand is an inorganic ion (Ca2+ ) rather than a molecule so there was no structural template to guide medicinal chemistry. Nonetheless, small molecules targeting this receptor were discovered. Calcimimetics are agonists or positive allosteric modulators of the CaR, while calcilytics are antagonists and all to date are negative allosteric modulators...
2018: Progress in Medicinal Chemistry
https://www.readbyqxmd.com/read/29668666/a-comparison-of-robotic-versus-open-thyroidectomy-for-papillary-thyroid-cancer
#13
Se Hyun Paek, Kyung Ho Kang, Sung Jun Park
OBJECTIVES: This study investigated the potential advantages of robotic thyroidectomy and determined whether it is safe and complete compared with conventional open surgery in patients with papillary thyroid cancer. MATERIALS AND METHODS: A total 376 consecutive patients who underwent total thyroidectomy and central neck dissection for papillary thyroid cancer from February 2013 to July 2014 were retrospectively reviewed. Postoperative complication rates and surgical completeness were compared between the robotic and open groups...
April 17, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29663634/barakat-syndrome-revisited
#14
Amin J Barakat, Margarita Raygada, Owen M Rennert
Barakat syndrome also known as HDR syndrome (Online Mendelian Inheritance in Man [OMIM] 146255), was first described by Barakat et al. in . It is a rare genetic disorder characterized by the triad of hypoparathyroidism "H," sensorineural deafness "D," and renal disease "R." The defect is caused by deletions in chromosome 10p14 or mutations in the GATA3 gene. Although the syndrome has been phenotypically defined by this triad the literature identifies cases with different components with, or without GATA3 defects making the definition of the syndrome confusing...
April 16, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29663329/prophylactic-thyroidectomy-in-children-with-multiple-endocrine-neoplasia-type-2
#15
F P Prete, T Abdel-Aziz, C Morkane, C Brain, T R Kurzawinski
BACKGROUND: In patients with multiple endocrine neoplasia type 2 (MEN2) syndrome, genetic testing offers early diagnosis, stratifies the risk of developing medullary thyroid cancer (MTC) and informs the timing of thyroidectomy. The efficacy of treatment, which depends on timely and safe surgery, is not well established. METHODS: This was a retrospective review of diagnostic and clinicopathological outcomes of prophylactic thyroidectomy in children with MEN2 between 1995 and 2013 in the UK...
April 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29663312/mortality-in-patients-with-permanent-hypoparathyroidism-after-total-thyroidectomy
#16
M Almquist, K Ivarsson, E Nordenström, A Bergenfelz
BACKGROUND: Permanent hypoparathyroidism remains the most common adverse outcome after total thyroidectomy, but long-term effects of hypoparathyroidism are unknown. The aim was to investigate mortality in patients with permanent hypoparathyroidism after total thyroidectomy. METHODS: Data from the Scandinavian Quality Register for Thyroid, Parathyroid and Adrenal Surgery were linked with the Swedish National Prescription Register for Pharmaceuticals and the Swedish National Inpatient Register...
April 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29658811/parathyroid-autotransplantation-during-thyroid-surgery-where-we-are-a-systematic-review-on-indications-and-results
#17
Olga Iorio, Vincenzo Petrozza, Antonietta De Gori, Marco Bononi, Natale Porta, Giorgio De Toma, Giuseppe Cavallaro
INTRODUCTION: Hypoparathyroidism still represents an important concern in thyroid surgery. Careful dissection with identification and preservation of parathyroid glands in situ remains the best way to maintain gland vitality and avoid post-operative failure. Nevertheless, parathyroid glands are still inadvertently removed in up to 11% of cases. Parathyroid autotransplantation may represent the only way to restore parathyroid gland functionality in case of inadvertent removal or devascularization during thyroid surgery...
April 16, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29595868/iatrogenic-hypoparathyroidism-after-surgery-for-retrosternal-goitre-a-single-centre-retrospective-analysis
#18
G Damiano, G Cocchiara, V D Palumbo, F Fatica, F Caternicchia, A I Lo Monte, M Cajozzo
AIM: The aim of this study is to assess, retrospectively, the incidence of secondary hypoparathyroidism after total thyroidectomy in patients with retrosternal goitre. MATERIAL AND METHODS: From January 2009 to September 2015, 622 patients who undergone total thyroidectomy for goitre, were retrospectively observed. The patients were divided into two group: Group A, including 58 patients with retrosternal goitre and Group B, including 562 patients with in situ goitre...
March 2018: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29594260/endocrine-disorders-in-primary-mitochondrial-disease
#19
Iman S Al-Gadi, Richard H Haas, Marni J Falk, Amy Goldstein, Shana E McCormack
Context: Endocrine disorders are common in individuals with mitochondrial disease. To develop evidence-based screening practices in this high-risk population, updated age-stratified estimates of the prevalence of endocrine conditions are needed. Objective: To measure the point prevalence of selected endocrine disorders in individuals with mitochondrial disease. Design Setting and Patients: The North American Mitochondrial Disease Consortium Patient Registry is a large, prospective, physician-curated cohort study of individuals with mitochondrial disease...
April 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29594052/parathyroid-hormone-assays-following-total-thyroidectomy-is-there-a-predictive-value
#20
Camille Galy-Bernadoy, Benjamin Lallemant, Guillaume Chambon, Huy Trang Pham, Christophe Reynaud, Caroline Alovisetti, Quentin Bonduelle, Anne Marie Guedj, Serge Lumbroso, David-Paul De Brauwere
Objectives: Parathyroid hormone (PTH) is a risk marker for hypoparathyroidism (hypoPTH). This study aimed to determine the predictive values of early PTH assays carried out at the moment of skin closure (PTH SC), to establish a treatment algorithm, identifying two threshold values. We assessed the reproducibility of this approach with two different immunoassay kits (hypoPTH) after total thyroidectomy, but its practical application is not consensual. Study Design: We conducted a prospective descriptive study, including all patients who underwent a total thyroidectomy between March 2012 and November 2013...
January 2018: European Thyroid Journal
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