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Hypoparathyroid

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https://www.readbyqxmd.com/read/27933172/brown-tumor-of-the-jaw-after-pregnancy-and-lactation-in-a-men1-patient
#1
Anna Casteràs, Lídia Darder, Carles Zafon, Juan Antonio Hueto, Margarita Alberola, Enric Caubet, Jordi Mesa
: Skeletal manifestations of primary hyperparathyroidism (pHPT) include brown tumors (BT), which are osteoclastic focal lesions often localized in the jaws. Brown tumors are a rare manifestation of pHTP in Europe and USA; however, they are frequent in developing countries, probably related to vitamin D deficiency and longer duration and severity of disease. In the majority of cases, the removal of the parathyroid adenoma is enough for the bone to remineralize, but other cases require surgery...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27913036/pattern-of-calcium-and-parathyroid-hormone-normalization-at-12-months-follow-up-after-parathyroid-operation
#2
Olga A Lavryk, Allan E Siperstein
BACKGROUND: At 12 months after a parathyroid operation, we expect cured patients to have biochemical profiles similar to those of healthy individuals. The aim of the current study was to compare the biochemical characteristics patients at 12 months after parathyroidectomy for primary sporadic hyperparathyroidism with those of healthy controls. METHODS: A total of 547 patients who underwent parathyroid neck operation for primary sporadic hyperparathyroidism from 2000-2014 were analyzed...
November 29, 2016: Surgery
https://www.readbyqxmd.com/read/27901178/hypoparathyroidism-and-pseudohypoparathyroidism-etiology-laboratory-features-and-complications
#3
Maicon Piana Lopes, Breno S Kliemann, Ileana Borsato Bini, Rodrigo Kulchetscki, Victor Borsani, Larissa Savi, Victoria Z C Borba, Carolina A Moreira
Objectives: To identify a clinical profile and laboratory findings of a cohort of hypoparathyroidism patients and determine the prevalence and predictors for renal abnormalities. Materials and methods: Data from medical records of five different visits were obtained, focusing on therapeutic doses of calcium and vitamin D, on laboratory tests and renal ultrasonography (USG). Results: Fifty-five patients were identified, 42 females and 13 males; mean age of 44...
November 24, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27867862/intermittent-neural-monitoring-of-the-recurrent-laryngeal-nerve-in-surgery-for-recurrent-goiter
#4
REVIEW
Beata Wojtczak, Marcin Barczyński
Reoperative thyroid surgery is still challenging even for skilled surgeons, and is associated with a higher incidence of complications, such as hypoparathyroidism and recurrent laryngeal nerve (RLN) palsy. Displacement of the RLN, scar tissue from previous neck surgery and difficulty in maintaining good hemostasis are risk factors in reoperations. The prevalence of RLN injury in reoperative thyroid surgery ranges as high as 12.5% for transient injury and up to 3.8% for permanent injury. Bilateral paresis can also occur during reoperations, and is a dangerous complication influencing the quality of life, sometimes requiring tracheostomy...
October 2016: Gland Surgery
https://www.readbyqxmd.com/read/27866716/can-we-consider-immediate-complications-after-thyroidectomy-as-a-quality-metric%C3%A2-of-operation
#5
Jean-Christophe Lifante, Cécile Payet, Fabrice Ménégaux, Frédéric Sebag, Jean-Louis Kraimps, Jean-Louis Peix, François Pattou, Cyrille Colin, Antoine Duclos
BACKGROUND: Permanent recurrent laryngeal nerve palsy and hypoparathyroidism are 2 major complications after thyroid operation. Assuming that the rate of immediate complications can predict the permanent complication rate, some authors consider these complications as a valid metric for assessing the performance of individual surgeons. This study aimed to determine the correlation between rates of immediate and permanent complications after thyroidectomy at the surgeon level. METHODS: We conducted a prospective, cross-sectional study in 5 academic hospitals between April 2008 and December 2009...
November 17, 2016: Surgery
https://www.readbyqxmd.com/read/27866715/normohormonal-primary-hyperparathyroidism-is-a-distinct%C3%A2-form-of-primary-hyperparathyroidism
#6
Megan K Applewhite, Michael G White, Jennifer Tseng, Maryam K Mohammed, Frederic Mercier, Edwin L Kaplan, Peter Angelos, Tamara Vokes, Raymon H Grogan
BACKGROUND: Normohormonal primary hyperparathyroidism presents diagnostic and intraoperative challenges, and current literature is conflicting about management. We aim to better define normohormonal primary hyperparathyroidism in order to improve the care for these patients. METHODS: In the study, 516 consecutive patients undergoing parathyroidectomy for primary hyperparathyroidism were divided into 2 groups: classic primary hyperparathyroidism (classic primary hyperparathyroidism, increased serum levels of calcium, and parathyroid hormone) and normohormonal primary hyperparathyroidism (hypercalcemia, normal serum levels of parathyroid hormone)...
November 17, 2016: Surgery
https://www.readbyqxmd.com/read/27861338/enhanced-identification-and-functional-protective-role-of-carbon-nanoparticles-on-parathyroid-in-thyroid-cancer-surgery-a-retrospective-chinese-population-study
#7
Chenlei Shi, Bo Tian, Shengze Li, Tiefeng Shi, Huadong Qin, Shaoyan Liu
The aim of this study was to determine the effects of nanocarbon particles in combination with meticulous capsular dissection on enhancing the identification and protecting the function of parathyroid glands in thyroid cancer surgery.The data of 97 patients with papillary thyroid tumors diagnosed and treated at the Second Affiliated Hospital, Harbin Medical University between January 2014 and February 2015 were reviewed. Data regarding the sex, age, calcium and parathyroid hormone (PTH) levels, tumor size, multifocality, T stage, and extrathyroid invasion were collected...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27857805/neuropsychiatric-phenotype-in-a-child-with-pseudohypoparathyroidism
#8
Paola Visconti, Annio Posar, Maria Cristina Scaduto, Angelo Russo, Federica Tamburrino, Laura Mazzanti
Pseudohypoparathyroidism (PHP) is a rare heterogeneous genetic disease characterized by end-organ resistance to parathyroid hormone. In adulthood, heterogeneous neurological and psychiatric disorders have been reported which are associated with hypoparathyroidism in general and with PHP in particular, while for childhood, data are scanty. We report a case of a boy with PHP type 1b, in whom neurological signs at the onset prevailed, characterized by tic-like dyskinesias associated with a series of heterogeneous not well-defined neurological and behavioral features, describing the diagnostic work-up performed and the follow-up...
July 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/27857062/identification-of-an-orally-active-small-molecule-pthr1-agonist-for-the-treatment-of-hypoparathyroidism
#9
Tatsuya Tamura, Hiroshi Noda, Eri Joyashiki, Maiko Hoshino, Tomoyuki Watanabe, Masahiko Kinosaki, Yoshikazu Nishimura, Tohru Esaki, Kotaro Ogawa, Taiji Miyake, Shinichi Arai, Masaru Shimizu, Hidetomo Kitamura, Haruhiko Sato, Yoshiki Kawabe
Parathyroid hormone (PTH) is essential for calcium homeostasis and its action is mediated by the PTH type 1 receptor (PTHR1), a class B G-protein-coupled receptor. Hypoparathyroidism and osteoporosis can be treated with PTH injections; however, no orally effective PTH analogue is available. Here we show that PCO371 is a novel, orally active small molecule that acts as a full agonist of PTHR1. PCO371 does not affect the PTH type 2 receptor (PTHR2), and analysis using PTHR1-PTHR2 chimeric receptors indicated that Proline 415 of PTHR1 is critical for PCO371-mediated PTHR1 activation...
November 18, 2016: Nature Communications
https://www.readbyqxmd.com/read/27813709/serum-1-25-dihydroxyvitamin-d-as-a-biomarker-of-the-absence-of-hypercalciuria-in-postsurgical-hypoparathyroidism
#10
Luis García-Pascual, María José Barahona, Verónica Perea, Rafael Simó
CONTEXT: Hypercalciuria is an adverse event of postsurgical hypoparathyroidism treatment which can lead to renal complications. The collection of 24-hour urine to detect hypercalciuria is often considered unreliable. OBJECTIVE: To find useful predictive biomarkers of hypercalciuria in patients with permanent postsurgical hypoparathyroidism under treatment with oral calcium and calcitriol supplements. DESIGN: Prospective cross-sectional study...
November 4, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27813708/vertebral-fractures-and-bone-mineral-density-in-patients-with-idiopathic-hypoparathyroidism-on-long-term-follow-up
#11
Himika Chawla, Soma Saha, Devasenathipathy Kandaswamy, Raju Sharma, Vishnubhatla Sreenivas, Ravinder Goswami
CONTEXT: Bone mineral density (BMD) is increased in patients with idiopathic hypoparathyroidism (IH). PTH deficiency, hypocalcemic seizures and anticonvulsants could compromise skeletal health in IH leading to vertebral fractures. However, there is limited information on the prevalence of vertebral fractures in hypoparathyroidism. OBJECTIVE: To assess the prevalence of vertebral fractures and related factors in a cohort of patients with IH and change in BMD during long-term follow-up...
November 4, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27813050/long-term-follow-up-and-treatment-of-postoperative-permanent-hypoparathyroidism-in-patients-with-medullary-thyroid-carcinoma-differences-in-complete-and-partial-disease
#12
G Leidig-Bruckner, T Bruckner, F Raue, K Frank-Raue
This study aimed to identify factors influencing long-term outcome in complete or partial postoperative hypoparathyroidism (parathyroid hormone ≤10 or >10 ng/l, respectively) in medullary thyroid carcinoma (MTC). It was designed as retrospective, long-term follow-up with single-center outpatient visits. Quality of treatment, renal calcification, and function were evaluated. In 33 patients with MTC and postoperative hypoparathyroidism, current medication includes: calcium (73%), calcitriol (73%), alfacalcidol (6%), dihydrotachysterol (3%), and cholecalciferol supplements (21%)...
December 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27806782/-modified-minimally-invasive-video-assisted-lateral-neck-dissection-for-papillary-thyroid-carcinoma-a-series-of-130-cases
#13
D G Zhang, L Gao, L Xie, G F He, L Fang, J Chen, Y W Miao, Z Z Wang
Objective: To discuss the feasibility, safety and oncologic completeness of modified minimally invasive video-assisted lateral neck dissection (MIVALND) for papillary thyroid carcinoma. Methods: Data of 130 patients from Department of Head and Neck Surgery, Sir Run Run Shaw Hospital, Medical School, Zhejiang University undergoing MIVALND from January 2013 to September 2015 were reviewed retrospectively. There were 31 male and 99 female patients with the mean age of (39±11) years. The thyroidectomy and central compartment dissection were performed under a direct visual field or video-assisted (VA) approach, lateral neck dissection was performed via the VA approach...
November 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27806781/-clinical-and-anatomic-study-of-preserving-parathyroid-specific-adipose-attachments-in-total-thyroidectomy
#14
F L Wang, G Miao, J M Wei, D H Xie, J Chen, W D Dai, Y Peng, M X Wu, L Chen, S R He, D G Liu, Y Wang, L X Guo
Objective: To discuss the anatomical characteristic and important role of specific adipose attachments in preserving parathyroid function in total thyroidectomy. Methods: Parathyroid glands of 91 cases underwent total thyroidectomy in Department of General Surgery, Beijing Hospital from January to November 2015 were observed prospectively. There were 19 male and 72 female patients, aging from 25 to 74 years with an average age of (52±12) years. Preoperative ultrasound examination, analysis of intraoperative high definition images, and postoperative pathological examination were used to detect the origins of the parathyroid micro vascular structures and the characteristics of parathyroid specific adipose attachments...
November 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27805845/presence-of-auto-reactive-mhc-class-i-restricted-calcium-sensing-receptor-casr-specific-cd8-t-cells-in-idiopathic-hypoparathyroidism
#15
Samrina Mahtab, Utpreksha Vaish, Soma Saha, Archana Singh, Ravinder Goswami, Rajni Rani
CONTEXT: Autoimmunity to Calcium sensing receptor (CaSR) has been implicated in aetiopathogenesis of Idiopathic hypoparathyroidism (IH). While humoral immune responses have been shown, cell mediated auto-immune responses have not been demonstrated. OBJECTIVE: To study CaSR specific cytotoxic T cell responses in PBMCs of IH patients. DESIGN: Twenty four peptides of CaSR (RH1-RH24) were evaluated for their ex-vivo potential to stimulate PBMCs from IH patients and controls in IFN-γ ELISPOT assays...
November 2, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27803672/autosomal-dominant-hypocalcemia-hypoparathyroidism-types-1-and-2
#16
REVIEW
Kelly L Roszko, Ruiye D Bi, Michael Mannstadt
Extracellular calcium is essential for life and its concentration in the blood is maintained within a narrow range. This is achieved by a feedback loop that receives input from the calcium-sensing receptor (CASR), expressed on the surface of parathyroid cells. In response to low ionized calcium, the parathyroids increase secretion of parathyroid hormone (PTH) which increases serum calcium. The CASR is also highly expressed in the kidneys, where it regulates the reabsorption of calcium from the primary filtrate...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27794246/incidental-papillary-thyroid-carcinoma-in-thyroglossal-duct-cyst-case-report
#17
Ana Karen Lira Medina, Eliseo Fernandez Berdeal, Ernesto Bernal Cisneros, Rebeca Betancourt Galindo, Pamela Frigerio
INTRODUCTION: The thyroglossal cyst is found in 7% of the population and the incidental papillary thyroid carcinoma in thyroglossal cyst is a rare entity with an incidence 1 to 2%. The clinical presentation is indistinguishable from a benign lesion and the histopathological postoperative study defines the diagnosis. Papillary carcinomas have favorable prognosis and cervical or distant metastases are rare. There is now a consensus on the indication of total thyroidectomy, radioablation with iodine and/or suppressive therapy with levothyroxine after being removed surgically [1-3] (Patrucco et al...
October 15, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27784959/endocrine-manifestations-in-celiac-disease
#18
REVIEW
Hugh James Freeman
Celiac disease (CD) is an autoimmune small intestinal mucosal disorder that often presents with diarrhea, malabsorption and weight loss. Often, one or more associated endocrine disorders may be associated with CD. For this review, methods involved an extensive review of published English-language materials. In children and adolescents, prospective studies have demonstrated a significant relationship to insulin-dependent or type 1 diabetes, whereas in adults, autoimmune forms of thyroid disease, particularly hypothyroidism, may commonly co-exist...
October 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27783154/hypoparathyroidism-after-total-thyroidectomy-in-patients-with-previous-gastric-bypass
#19
Raoul A Droeser, Johan Ottosson, Andreas Muth, Hella Hultin, Karin Lindwall-Åhlander, Anders Bergenfelz, Martin Almquist
PURPOSE: Case reports suggest that patients with previous gastric bypass have an increased risk of severe hypocalcemia after total thyroidectomy, but there are no population-based studies. The prevalence of gastric bypass before thyroidectomy and the risk of hypocalcemia after thyroidectomy in patients with previous gastric bypass were investigated. METHODS: By cross-linking The Scandinavian Quality Registry for Thyroid, Parathyroid and Adrenal Surgery with the Scandinavian Obesity Surgery Registry patients operated with total thyroidectomy without concurrent or previous surgery for hyperparathyroidism were identified and grouped according to previous gastric bypass...
October 26, 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/27780677/total-thyroidectomy-alone-versus-ipsilateral-versus-bilateral-prophylactic-central-neck-dissection-in-clinically-node-negative-differentiated-thyroid-carcinoma-a-retrospective-multicenter-study
#20
P G Calò, G Conzo, M Raffaelli, F Medas, C Gambardella, C De Crea, L Gordini, R Patrone, L Sessa, E Erdas, E Tartaglia, C P Lombardi
BACKGROUND: Central neck dissection (CND) remains controversial in clinically node-negative differentiated thyroid carcinoma (DTC) patients. The aim of this multicenter retrospective study was to determine the rate of central neck metastases, the morbidity and the rate of recurrence in patients treated with total thyroidectomy (TT) alone or in combination with bilateral or ipsilateral CND. METHODS: The clinical records of 163 clinically node-negative consecutive DTC patients treated between January 2008 and December 2010 in three endocrine surgery referral units were retrospectively evaluated...
October 13, 2016: European Journal of Surgical Oncology
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